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    9983 results match your criteria Acta Dermato-Venereologica [Journal]

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    Validation of Pruritus Measures Gathered with the Electronic Patient-reported Outcome System MoPat.
    Acta Derm Venereol 2017 Sep 20. Epub 2017 Sep 20.
    Institute of Medical Informatics, University of Münster, Domagkstrasse 9, DE-48149 Münster, Germany.
    In order to improve diagnosis and treatment, physicians require information about the social context and quality of life of their patients. The Center for Chronic Pruritus at the University Hospital Münster achieves this goal using the electronic patient-reported outcome system “Mobile Patient Survey”, which assesses pruritus and quality of life measures. The aim of this study is to evaluate the consistency and reliability of such measures. Read More

    Long-term Impact of Ixekizumab on Psoriasis Itch Severity: Results From a Phase III Clinical Trial and Long-term Extension.
    Acta Derm Venereol 2017 Sep 20. Epub 2017 Sep 20.
    Beth Israel Deaconess Hospital and Harvard Medical School, 375 Longwood Ave, Boston, MA 02215, USA.
    Itching is a prevalent plaque psoriasis symptom. Ixekizumab, an IL-17A antagonist, has demonstrated rapid, significant improvements in itch severity over 12 weeks in Phase III psoriasis trials (UNCOVER-1, UNCOVER-2). We assessed the long-term (through 60 weeks) effect of ixekizumab maintenance therapy (80-mg ixekizumab every 4 weeks [IXEQ4W]) on itch severity, using the Itch Numeric Rating Scale, in psoriasis patients who received ixekizumab, placebo, or etanercept for 12 weeks in the Phase III UNCOVER-3 trial. Read More


    Brachioradial Pruritus and Notalgia Paraesthetica: A Comparative Observational Study of Clinical Presentation and Morphological Pathologies.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Center for Chronic Pruritus, Department of Dermatology, University Hospital Münster, Von- Esmarch-Str. 58, DE-48149 Münster, Germany.
    Brachioradial pruritus (BRP) and notalgia paraesthetica (NP) represent 2 of the most common neuropathic itch syndromes. A total of 58 consecutive patients presenting at the Center for Chronic Pruritus, University Hospital Münster, were analysed with regard to clinical presentation, anatomical and morphological pathologies, impairment in quality of life, and response to treatment with topical capsaicin. Patients with BRP reported stinging and burning more often than those with NP. Read More

    Psychological Health Status and Health-related Quality of Life in Adults with Atopic Dermatitis: A Nationwide Cross-sectional Study in South Korea.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Bucheon 14584, Korea.
    Atopic dermatitis (AD) is a chronic inflammatory skin disorder. Patients with AD often experience psychological distress and poor health-related quality of life (HRQoL). The aim of this study was to investigate the association of several psychological health statuses and poor HRQoL in an adult population with AD in South Korea. Read More

    The Association Between Low Grade Systemic Inflammation and Skin Diseases: A Cross-sectional Survey in the Northern Finland Birth Cohort 1966.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Medical Research Center, PEDEGO Research Group, University of Oulu and Oulu University Hospital, FIN-90029 OYS Oulu, Finland.
    Low grade inflammation is associated with many noncommunicable diseases. The association between skin diseases in general and systemic inflammation has not previously been studied at the population level. A whole-body investigation on 1,930 adults belonging to Northern Finland Birth Cohort 1966 was performed and high sensitive C-reactive protein (CRP) level was measured as a marker of low grade inflammation in order to determine the association between low grade inflammation and skin diseases in an unselected adult population. Read More

    Distinct Patterns and Aetiology of Chromonychia.
    Acta Derm Venereol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Dermatology, Chonnam National University Medical School, 160 Baekseo-ro, Dong-gu, Gwangju, 61469, Korea.
    Abnormal colouring of the nails may be a sign of underlying systemic or local disorders. This study investigated the prevalence and causes of chromonychia as a whole, as well as of each subtype. Among 163 patients with chromonychia, trauma was the pathogenesis in up to 20. Read More

    Granuloma Faciale Treatment: A Systematic Review.
    Acta Derm Venereol 2017 Sep 7. Epub 2017 Sep 7.
    Department of Dermatology and Allergology, University Hospital Jena, Erfurter Strasse 35, DE-07743 Jena, Germany.
    Granuloma faciale is an uncommon benign chronic dermatosis characterized by reddish-brown to violaceous asymptomatic plaques appearing predominantly on the face. The pathogenesis of granuloma faciale remains unclear, and it is frequently unresponsive to therapy. This systematic review aims to summarize all recent publications on the management of granuloma faciale. Read More

    Incidence and Regression of Actinic Keratoses in Organ Transplant Recipients.
    Acta Derm Venereol 2017 Aug 30. Epub 2017 Aug 30.
    Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Read More

    Epidemiology and Outcome of Squamous Cell Carcinoma in Epider-molysis Bullosa in Australia and New Zealand.
    Acta Derm Venereol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Dermatology, George Hospital, Gray St, Kogarah, Sydney, Australia.
    We investigate the epidemiology and outcomes of squamous cell carcinoma (SCC) in recessive dystrophic epidermolysis bullosa (RDEB) from the Australasian EB registry cohort. Seventeen out of 49 (34.6%) RDEB patients developed at least one SCC. Read More

    Role of Substance P and Its Receptor Neurokinin 1 in Chronic Prurigo: a Randomized, Proof-of-Concept, Controlled Trial with Topical Aprepitant.
    Acta Derm Venereol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, DE-10117 Berlin, Germany.
    Substance P (SP) and its receptor neurokinin 1 (NK1R) are thought to be involved in the pathogenesis of chronic prurigo. Here, we assessed SP serum levels, cutaneous NK1R expression, and the effects of topical aprepitant, an NK1R antagonist, in patients with chronic prurigo. SP and NK1R were increased, compared with controls, in the serum and in lesional vs. Read More

    Differential Diagnosis of Palmoplantar Eczema in Psoriatico: Chronic Allergic Contact Dermatitis and/or Psoriasis?
    Acta Derm Venereol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Dermatology and Venereology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, DE-39120 Magdeburg, Germany.
    Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed. Samples were allocated to histopathological diagnoses of psoriasis, contact dermatitis or EIP. Read More

    Temporal Stability of the Healthy Human Skin Microbiome Following Dead Sea Climatotherapy.
    Acta Derm Venereol 2017 Aug 17. Epub 2017 Aug 17.
    Biofilm Research Laboratory, Institute of Dental Sciences, Faculty of Dental Medicine, The Hebrew University of Jerusalem, POB 12272, Jerusalem 91120, Israel.
    Dead Sea climatotherapy (DSC) is a therapeutic modality for a variety of chronic skin conditions, yet there has been scarce research on the relationship between the cutaneous microbiota and disease states in response to DSC. We characterized the skin bacterial and fungal microbiome of healthy volunteers who underwent DSC. Bacterial community diversity remained similar before and after treatment, while fungal diversity was significantly reduced as a result of the treatment. Read More

    Long-Term Trend in Sunscreen Use among Beachgoers in Denmark.
    Acta Derm Venereol 2017 Aug 17. Epub 2017 Aug 17.
    Department of Dermatology D92,, Bispebjerg Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen, Denmark.
    This observational study examined the trend from the 1990s to 2016 of sunscreen use, sun protection factor (SPF) and quantity of sunscreen applied amongst beachgoers in Denmark. In 1997, 1998, 1999 and 2016, a total of 1,306 beachgoers were asked if they had used sunscreen on a specific day and, if so, of what SPF. In 1992 and 2016 another 143 beachgoers had their sunscreen bottles weighed before and after application. Read More

    Agreeableness as Predictor of Induced Scratching in Patients with Atopic Dermatitis: A Replication Study.
    Acta Derm Venereol 2017 Aug 17. Epub 2017 Aug 17.
    Institute of Medical Psychology, Justus-Liebig-University, Klinikstraße 29, DE-35392 Gießen, Germany.
    In patients with atopic dermatitis agreeableness and public self-consciousness have previously been shown to be significant predictors of induced scratching, while depression was significantly related to induced itch. This study aimed to replicate these findings. Itch and scratching were induced by videos of crawling insects or skin diseases. Read More

    Determinants of Psychosocial Health in Psoriatic Patients: A Multi-national Study.
    Acta Derm Venereol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
    There are limited data on the differences in the impact of psoriasis between various countries with respect to quality of life (QoL). The aim of this study was to explore the psychosocial health of patients with psoriasis in different European countries. A total of 682 patients were recruited in 13 European countries. Read More

    Risk of Non-melanoma Skin Cancer in Patients with Chronic Kidney Disease and its Relationship to Uraemic Pruritus.
    Acta Derm Venereol 2017 Aug 10. Epub 2017 Aug 10.
    Department of Dermatology and Medical Research, Cardinal Tien Hospital, New Taipei City, Taiwan.
    This study investigated the risk of non-melanoma skin cancer (NMSC) in pre-dialysis patients with chronic kidney disease (CKD) and explored associated risk factors. A population-based cohort of 1,515,858 Taiwanese CKD patients was included. The standardized incidence ratio (SIR) for incident NMSC was determined. Read More

    Hyperhidrosis Substantially Reduces Quality of Life in Children: A Retrospective Study Describing Symptoms, Consequences and Treatment with Botulinum Toxin.
    Acta Derm Venereol 2017 Aug 1. Epub 2017 Aug 1.
    Hidrosis Clinic, Warfvinges väg 35, SE-112 51 Stockholm, Sweden.
    Studies on children with hyperhidrosis are sparse. This retrospective study presents clinical data and quality of life, along with treatment effect and safety of botulinum toxin (BTX). Case reports from 366 children were included to capture the medical history of hyperhidrosis. Read More


    Coincident Metastatic Melanoma and Merkel Cell Carcinoma with Complete Remission on Treatment with Pembrolizumab.
    Acta Derm Venereol 2017 Aug 1. Epub 2017 Aug 1.
    Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Josef-Schneider-Straße 2, DE-97080 Würzburg, Germany.

    Lethal Melanomas: A Population-based Registry Study in Western Sweden from 1990 to 2014.
    Acta Derm Venereol 2017 Aug 1. Epub 2017 Aug 1.
    Department of Dermatology and Venereology, Institute of Clinical Sciences at the Sahlgrenska Academy, University of Gothenburg, SE-413 45 Gothenburg, Sweden.
    The incidence rates of thin melanomas (≤1 mm Breslow thickness) have increased in many fair-skinned populations, prompting a need to better identify patients with thin melanomas who will eventually die from the disease. This study aimed to describe the clinicopathological characteristics of lethal melanomas in Western Sweden, with a focus on thin lesions. Population-based data on invasive melanomas diagnosed during the years 1990 to 2014 were extracted from the Swedish Melanoma Registry, and linked to the Swedish Cause of Death Registry. Read More

    Seven Non-melanoma Features of Facial Lesions: A Dermatoscopy Algorithm to Rule Out Melanoma.
    Acta Derm Venereol 2017 Aug 1. Epub 2017 Aug 1.
    Department of Dermatology, Medical University of Vienna, Wien, Austria.
    Facial melanoma is difficult to diagnose and dermatoscopic features are often subtle. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value. In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas. Read More

    Mycoplasma genitalium and Macrolide Resistance-associated Mutations in the Skåne Region of Southern Sweden 2015.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Laboratory Medicine, Division of Medical Microbiology, Lund University, Skåne Laboratory Medicine, Sölvegatan 23, SE-222 53 Lund, Sweden.
    Mycoplasma genitalium is a sexually transmitted infection ordinarily treated with azithromycin. Emerging resistance to macrolide is linked to mutations in the 23S rRNA gene. We analysed the frequency of such mutations of M. Read More

    Agreement Between Self-reported Inflammatory Skin Disorders and Dermatologists' Diagnosis: A Cross-sectional Diagnostic Study.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Dermatology, Centre Hospitalier Universitaire Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, FR-94010 Créteil, France.

    Circulating Tumour DNA for Monitoring Treatment Response to Anti-PD-1 Immunotherapy in Melanoma Patients.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Dermatology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto 390-8621, Japan.
    Anti-programmed cell death-1 (anti-PD-1) antibody shows high therapeutic efficacy in patients with advanced melanoma. However, assessment of its therapeutic activity can be challenging because of tumour enlargement associated with intratumoural inflammation. Because circulating tumour DNA (ctDNA) correlates with tumour burden, we assessed the value of ctDNA levels as an indicator of tumour changes. Read More

    Use of Molecular Biology Techniques in Sarcoidal Granulomatous Dermatitis: A Clinicopathological and Molecular Approach with Diagnostic Implications.
    Acta Derm Venereol 2017 Jul 6. Epub 2017 Jul 6.
    Department of Dermatology/Medicine, Universitat Autònoma de Barcelona, Passeig de la Vall d'Hebron, 119-129, ES-08035 Barcelona, Spain.

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