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    10093 results match your criteria Acta Dermato-Venereologica [Journal]

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    8-Methoxypsoralen Plus Ultraviolet A Reduces the Susceptibility of Murine Skin to Mount a Psoriatic Response to Imiquimod Linked with Senescence and Downregulation of Interleukin-9, 17 and Interferon-gamma.
    Acta Derm Venereol 2018 Feb 13. Epub 2018 Feb 13.
    Research Unit for Photodermatology, Department of Dermatology and Venereology, Medical University of Graz, AT-8036 Graz, Austria.
    The effects of 8-methoxypsoralen plus ultraviolet A (PUVA) and ultraviolet B (UVB) on imiquimod-induced psoriasis were examined in a mouse model. Mouse skin was treated with repetitive sub-phototoxic doses of PUVA or UVB before or during the induction of toll-like receptor 7/8 activation and psoriasis through the application of imiquimod. PUVA, to a greater degree than UVB, suppressed the established imiquimod-induced psoriatic phenotype, but pretreatment with PUVA prior to administration of imiquimod also reduced the susceptibility of murine skin to respond to imiquimod to a greater degree than did UVB. Read More

    Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics.
    Acta Derm Venereol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chałubińskiego 1, 50-368 Wrocław, Poland.
    Aquagenic pruritus is one of the main clinical features of polycythemia vera. The aim of this study was to analyse the clinical characteristics of aquagenic pruritus. The study group comprised 102 patients with molecularly confirmed polycythemia vera. Read More

    Evaluation of IgG4+ Plasma Cell Infiltration in Patients with Systemic Plasmacytosis and Other Plasma Cell-infiltrating Skin Diseases.
    Acta Derm Venereol 2018 Feb 13. Epub 2018 Feb 13.
    Department of Dermatology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
    Systemic plasmacytosis is a rare skin disorder characterized by marked infiltration of plasma cells in the dermis. IgG4-related disease is pathologically characterized by lymphoplasmacytic infiltration rich in IgG4+ plasma cells, storiform fibrosis, and obliterative phlebitis, accompanied by elevated levels of serum IgG4. Reports of cases of systemic plasmacytosis with abundant infiltration of IgG4+ plasma cells has led to discussion about the relationship between systemic plasmacytosis and IgG4-related disease. Read More

    Metastasis Risk of Cutaneous Squamous Cell Carcinoma in Organ Transplant Recipients and Immunocompetent Patients.
    Acta Derm Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Dermatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
    Organ transplant recipients (OTRs) have a high incidence of cutaneous squamous cell carcinoma (cSCC), and immunosuppression has been reported to be an important risk factor for metastasis. The aim of this study was to identify the metastasis risk over a 10-year period for 593 patients with cSCC, of whom 134 were OTR and 459 were immunocompetent. Metastasis incidence rate was 1,046 (95% confidence interval (95% CI) 524-2,096) per 100,000 person years in OTR and 656 (95% CI; 388-1,107) in immunocompetent patients, yielding an incidence rate ratio of 1. Read More

    Initial Results of Secukinumab Drug Survival in Patients with Psoriasis: A Multicentre Daily Practice Cohort Study.
    Acta Derm Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Department of Dermatology, Radboud University Medical Centre, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.
    Interleukin 17-antagonist secukinumab demonstrated high efficacy for treatment of psoriasis in randomized controlled trials (RCTs). However, performance in daily practice may differ from trials. Drug survival is a comprehensive outcome covering effectiveness and safety, suitable for analyses of daily practice. Read More

    Characteristics of Familial Melanoma in Valencia, Spain, Based on the Presence of CDKN2A Mutations and MC1R Variants.
    Acta Derm Venereol 2018 Feb 6. Epub 2018 Feb 6.
    Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, Spain.
    Melanoma results from a complex interplay between environmental factors and individual genetic susceptibility. Familial melanoma is attributable to predisposition genes with variable penetrance. The aim of this study was to identify differences between familial melanoma and sporadic cases in our population, based on the presence of CDKN2A mutations and MC1R variants. Read More

    Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome.
    Acta Derm Venereol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Dermatology, Venerology and Allergology, Charité Universitätsmedizin Berlin, DE-10117 Berlin, Germany.
    The microbiome may influence disease severity in atopic dermatitis. The skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. Optical density measurements were used to investigate bacterial growth under defined conditions in vitro. Read More

    Outcome of Combined Treatment of Surgery and Adjuvant Radio-therapy in Merkel Cell Carcinoma.
    Acta Derm Venereol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Dermatology and Venereology, Martin Luther University Halle-Wittenberg, DE-06097 Halle (Saale), Germany.
    In recent analyses of Merkel cell carcinoma, prognosis is poor even in stages I and II. We performed a monocentric retrospective study of 37 consecutive cases with Merkel cell carcinoma stage I to III treated with a combination of surgery and adjuvant radiation to evaluate progression-free and overall survival. The median primary tumor diameter was 17. Read More

    Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor.
    Acta Derm Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 2023A, 33136 Miami, FL, USA.
    Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Read More

    Longer Duration of Untreated Psychosis is Associated with Poorer Outcomes for Patients with Delusional Infestation.
    Acta Derm Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Psychiatry and Psychosomatics, I. M. Sechenov First Moscow State Medical University, Mental Health Research Center, 127006 Moscow, Russia.
    We examined the association between the duration of untreated psychosis and outcome for patients with delusional infestation. This multi-centre international study included consecutive 211 patients. Illness severity was evaluated at first presentation and outcome was measured with the Clinical Global Impression scale (CGI) at base line and follow-up. Read More

    Predictive Model for Response Rate to Narrowband Ultraviolet B Phototherapy in Vitiligo: A Retrospective Cohort Study of 579 Patients.
    Acta Derm Venereol 2018 Jan 24. Epub 2018 Jan 24.
    Department of Dermatology, Clinica Alemana de Santiago, Universidad del Desarrollo, Av. Manquehue Norte 1410, Vitacura, Santiago, Chile.
    Vitiligo is an acquired depigmenting disorder. To date, there is no predictive model for its response rate to narrowband ultraviolet B (NBUVB) phototherapy. The aim of this study was to investigate the different types of response of patients with non-segmental vitiligo undergoing NBUVB 3 times a week. Read More

    Stand-alone Emollient Treatment Reduces Flares After Discontinuation of Topical Steroid Treatment in Atopic Dermatitis: A Double-blind, Randomized, Vehicle-controlled, Left-right Comparison Study.
    Acta Derm Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, University of Lübeck, DE-23538 Lübeck, Germany.
    Prevention of flares is a main goal in the long-term treatment of atopic dermatitis (AD). This study investigated the efficacy of a water-in-oil emollient, containing licochalcone A, omega-6-fatty acids, ceramide 3 and glycerol, for prevention of flares in adults with mild to moderately severe AD, who had been treated with topical steroids, which had led to clearing of the inflammatory lesions and had been discontinued prior to inclusion. The study was a 12-week, double-blind, randomized, vehicle-controlled, left-right comparison test with the number of relapses, defined as re-occurrence of erythema for at least 3 consecutive days, considered the primary outcome. Read More

    Methotrexate Treatment for Pityriasis Rubra Pilaris: A Case Series and Literature Review.
    Acta Derm Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Medical University of Graz, AT-8036 Graz, Austria.
    Treatment recommendations for pityriasis rubra pilaris (PRP) are based solely on case reports and small case series, as to-date no randomized controlled trials are available. We present here a case series of 3 patients and a literature review of 28 studies treating a total of 116 patients, with the aim of providing data regarding efficacy and safety of methotrexate in the treatment of PRP. Methotrexate was effective in our patients; the review showed an overall response rate of 65. Read More

    Blood Predictive Biomarkers for Nivolumab in Advanced Melanoma.
    Acta Derm Venereol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Dermatology, University of Poitiers, Poitiers, France.
    Nivolumab response rate is 40% in metastatic melanoma. Few studies have evaluated pre-treatment biomarkers predictive of response. The aim of this study was to identify potential peripheral blood biomarkers associated with survival in patients with advanced melanoma treated with nivolumab. Read More

    Systemic Inflammation and Evidence of a Cardio-splenic Axis in Patients with Psoriasis.
    Acta Derm Venereol 2017 Dec 20. Epub 2017 Dec 20.
    Department of Dermatology and Venereology, Aarhus University Hospital, P.P. Orums gade 11, DK-8000 Aarhus, Denmark.
    The spleen is thought to play a role in atherosclerosis-associated immunity and cardiovascular research has indicated the existence of a cardio-splenic axis. The aim of this study was to assess splenic 18F-fluorodeoxyglucose uptake as a measure of systemic inflammation in patients with untreated psoriasis compared with historical controls assessed by positron emission tomography-computed tomography. Patients with moderate-to-severe psoriasis (n = 12, age 61. Read More

    Delusional Infestation: Perspectives from Scottish Dermatologists and a 10-year Case Series from a Single Centre.
    Acta Derm Venereol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Dermatology, Ninewells Hospital, NHS Tayside, DD2 1UU Dundee, United Kingdom.
    Perceptions of the clinical management of delusional infestation (DI) were compared with clinical outcomes in this 10-year case series from a single centre in Dundee, UK. An online questionnaire (survey-monkey, a TM brand of online survey available for free for basic use) was sent to Scottish Dermatologists to gauge their opinions and confidence in the management of DI. Also, a retrospective review of medical case notes of patients seen by dermatologists in one institution was undertaken and clinical outcomes were reported by patients' general practitioners. Read More

    Epidemiology and Medication Trends in Patients with Psoriasis: A Nationwide Population-based Cohort Study from Korea.
    Acta Derm Venereol 2017 Dec 21. Epub 2017 Dec 21.
    Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 06591 Seoul, Korea.
    This study investigated the prevalence of psoriasis and trends in prescription of medications for patients with psoriasis using the Korean National Health Insurance Claims Database from 2006 to 2015. The prevalence of psoriasis and psoriatic arthritis per 10,000 people increased from 47.4 to 61. Read More

    Light and Laser Modalities in the Treatment of Cutaneous Sarcoidosis: A Systematic Review.
    Acta Derm Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, University Hospital Jena, Erfurter Str. 35, DE-07743 Jena, Germany.
    Sarcoidosis is a systemic non-caseating granulomatous disease of unknown aetiology. Cutaneous manifestations are present in approximately 10-30% of the patients with the systemic form. Therapy is indicated in case of disabling symptoms, organ dysfunction or cosmetically distressing manifestation. Read More

    The Position of Targeted Next-generation Sequencing in Epidermo-lysis Bullosa Diagnosis.
    Acta Derm Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Hauptstrasse 7, DE-79104 Freiburg, Germany,
    The precise classification of epidermolysis bullosa (EB) into 4 main types and more than 30 subtypes is based on the level of skin cleavage, as well as clinical and molecular features, and is crucial for early prognostication, case management, genetic counselling and prenatal or pre-implantation diagnosis. We report here the molecular pathology of 40 consecutive cases of suspected EB, which were investigated by immunofluorescence mapping (IFM) and/or by a targeted next-generation sequencing (NGS) multi-gene panel. IFM correctly established the EB subtype in 76% of cases, while the molecular pathology was completely elucidated in 90% of cases by the targeted NGS multi-gene panel. Read More

    Clinical, Viral and Genetic Characteristics of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) in Shanghai, China.
    Acta Derm Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, China.
    DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. Read More

    Degree of Skin Barrier Disruption Affects Lipid Organization in Regenerated Stratum Corneum.
    Acta Derm Venereol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, NL-2333 CC Leiden, The Netherlands.
    Previously, a skin barrier repair model was developed to examine the effect of formulations on the lipid properties of compromised skin. In this model, the lipid organization mimics that of several skin diseases with impaired skin barrier and less dense lateral lipid organization. In addition, parakeratosis was occasionally observed. Read More

    Effects of a Hybrid Education Programme for Korean Mothers of Children with Atopic Dermatitis.
    Acta Derm Venereol 2017 Dec 12. Epub 2017 Dec 12.
    https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2806. https://www.medicaljournals.se/acta/content/html/10.2340/00015555-2806.
    Atopic dermatitis (AD), a common childhood skin disorder, can limit a child's learning and physical activities. South Korean mothers, as primary caregivers, experience anxiety and helplessness when caring for their ill children. The aim of this study was to develop a hybrid AD education programme (consisting of a face-to-face session followed by 8 online sessions) and evaluate its effects on anxiety, caregiving efficacy and caregiving behaviour among mothers of children with AD. Read More

    Significant Changes in the Skin Microbiome in Patients with Chronic Plaque Psoriasis after Treatment with Narrowband Ultraviolet B.
    Acta Derm Venereol 2017 Dec 4. Epub 2017 Dec 4.
    Division of Dermatology and Venereology, Region Jönköping County, Jönköping, Sweden.
    Changes in the skin microbiome have been shown to promote cutaneous inflammation. The skin microbiome of patients with chronic plaque type psoriasis was analysed before and after treatment with narrowband ultraviolet B (UVB). Swab samples of the microbiome were taken from lesional and non-lesional skin of 26 patients. Read More

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