650,112 results match your criteria Acta Dermato-Venereologica [Journal]


Rapid determination of 1,3-propanediol in fermentation process based on a novel surface-enhanced Raman scattering biosensor.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Nov 28;211:227-233. Epub 2018 Nov 28.

Beijing Bioprocess Key Laboratory, Beijing University of Chemical Technology, Beijing 100029, PR China; College of Science, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:

The production of 1,3-propanediol (1,3-PDO) is an important fermentation process. However, 1,3-PDO could not be distinguished separately and efficiently in fermentations previously because it has a highly similar molecular structure to the feedstock glycerol (GLY) and by-product lactic acid (Lac), which leads to the difficulty of quantification. In this paper, a low-cost and environmentally friendly biosensor based on surface-enhanced Raman scattering (SERS) technique was developed. Read More

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November 2018

A comparative study of thermal stability of TNT, RDX, CL20 and ANTA explosives using UV 266nm-time resolved photoacoustic pyrolysis technique.

Spectrochim Acta A Mol Biomol Spectrosc 2018 Dec 6;211:212-220. Epub 2018 Dec 6.

Advanced Centre of Research in High Energy Materials (ACRHEM), University of Hyderabad, 500046, India. Electronic address:

The paper reports the potential use of UV based pulsed photoacoustic spectroscopy to study the thermal stability of some well-known premier explosives such as TNT, RDX, CL20, and ANTA between 30 and 350°C range. The thermal PA spectra of samples were recorded using fourth harmonic wavelength i.e. Read More

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December 2018

Lifting, tasting, and carrying: The interaction of magnitude and valence effects in time perception.

Acta Psychol (Amst) 2018 Dec 11;193:1-10. Epub 2018 Dec 11.

Department of Psychological Sciences, University of Connecticut, USA; Department of Psychology, Gordon College, USA.

Magnitude effects (e.g., heavier or faster is longer) and valence effects (e. Read More

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December 2018

Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical-Laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura 285-8741, Japan. Electronic address:

Background: The levels of plasma sLR11, released from intimal SMCs, are positively associated with intima-media thickness (IMT) in asymptomatic subjects. We have evaluated the yet unknown pathological significance of sLR11 for plaque conditions in patients with carotid artery stenosis.

Methods: The presence of LR11 in carotid plaques was investigated using autopsy specimens. Read More

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December 2018

Pediatric reference intervals for clinical chemistry assays on Siemens ADVIA XPT/1800 and dimension EXL in the CALIPER cohort of healthy children and adolescents.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

CALIPER Program, Pediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada; Department of Laboratory Medicine & Pathobiology, Faculty of Medicine, University of Toronto, 1 King's College Cir, Toronto, ON M5S 1A8, Canada. Electronic address:

Introduction: Accurate reference intervals (RIs) are essential for clinical interpretation of laboratory test results; however, major gaps exist in pediatric RIs. The Canadian Laboratory Initiative on Pediatric Reference Intervals (CALIPER) has established age- and sex-specific pediatric RIs on various analytical platforms. The current study expands the CALIPER database by establishing age- and sex-specific RIs for biochemical assays on Siemens ADVIA XPT/1800 and Dimension EXL Systems. Read More

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December 2018

Evaluation of three advanced methodologies, COLD-PCR, microarray and ddPCR, for identifying the mutational status by liquid biopsies in metastatic colorectal cancer patients.

Clin Chim Acta 2018 Dec 11. Epub 2018 Dec 11.

Unit of Genomic for the Diagnosis of Human Pathologies, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy; Laboratory of Clinical Molecular Biology, IRCCS Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milano, Italy.

A major effort has been focused on the detection of oncogenes' mutations in diverse types of clinical specimens including formalin-fixed and paraffin embedded tissues, presently the gold-standard samples, up to plasma, that constitute a noninvasive alternative source of tumor DNA. The reliable detection of mutations in circulating tumor DNA requires a high analytical sensitivity. Here, we applied three different highly sensitive methodologies (COLD-PCR, a microarray-based approach and the droplet digital PCR, ddPCR) to identify mutations in the plasma of 30 metastatic colorectal cancer patients previously genotyped on tissue biopsy. Read More

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December 2018

Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model.

Acta Biomater 2018 Dec 11. Epub 2018 Dec 11.

Nankai University School of Medicine, Tianjin 300071, China; The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, The College of Life Science, Tianjin 300071, China. Electronic address:

Mesenchymal stem cell (MSC) transplantation has emerged as a very promising strategy for the treatments of peripheral artery disease (PAD). However, MSC-based therapies are limited by low cell retention and survival rate in the ischemic zone. Small molecular (SM) hydrogels have shown attractive abilities to enhance the therapeutic effects of human MSCs via promoting their proliferation or maintaining their differentiation potential. Read More

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December 2018
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Uridine diphosphate release mechanism in O-N-acetylglucosamine (O-GlcNAc) transferase catalysis.

Biochim Biophys Acta Gen Subj 2018 Dec 11. Epub 2018 Dec 11.

The Key Laboratory of Natural Medicine and Immuno-Engineering, Henan University, Kaifeng 475004, People's Republic of China. Electronic address:

O-linked N-acetylglucosamine transferase (OGT) is an essential enzyme that catalyzes the covalent bonding of N-acetylglucosamine (GlcNAc) to the hydroxyl group of a serine or threonine in the target protein. It plays an important role in many important cellular physiological catalytic reactions. Here, we determine the binding mode and the binding free energy of the OGT product (uridine diphosphate, UDP) as well as the hydrogen-bond-dependent release mechanism using extensive molecular dynamic simulations. Read More

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December 2018

The helix-to-sheet transition of an HIV-1 fusion peptide derivative changes the mechanical properties of lipid bilayer membranes.

Biochim Biophys Acta Biomembr 2018 Dec 11. Epub 2018 Dec 11.

Forschungszentrum Jülich GmbH, Jülich Centre for Neutron Science at SNS, Oak Ridge National Laboratory, Oak Ridge, TN 37831, United States of America.

A short sequence on the gp41 envelope protein of HIV-1 is integral to infection by the virus. Without this sequence, termed the fusion peptide (FP), the virus is far less effective at fusing with the cellular membrane. One of the interesting features of the isolated FP is that it transitions between an α-helical conformation and a β-sheet conformation in lipid bilayer membranes as a function of lipid composition and concentration, and the transition correlates with fusion. Read More

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December 2018

Peptide antibiotic trichogin in model membranes: Self-association and capture of fatty acids.

Biochim Biophys Acta Biomembr 2018 Dec 11. Epub 2018 Dec 11.

Institute of Chemical Kinetics and Combustion, RAS, Novosibirsk 630090, Russian Federation; Novosibirsk State University, Novosibirsk 630090, Russian Federation. Electronic address:

The antimicrobial action of peptides in bacterial membranes is commonly related to their mode of self-assembling which results in pore formation. To optimize peptide antibiotic use for therapeutic purposes, a study on the concentration dependence of self-assembling process is thus desirable. In this work, we investigate this dependence for peptaibol trichogin GA IV (Tric) in the 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) model membrane in the range of peptide concentrations between 0. Read More

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December 2018
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The role of RNA adenosine demethylases in the control of gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

Central European Institute of Technology (CEITEC), Masaryk University, Brno 625 00, Czech Republic. Electronic address:

RNA modifications are being recognized as an essential factor in gene expression regulation. They play essential roles in germ line development, differentiation and disease. In eukaryotic mRNAs, N-adenosine methylation (mA) is the most prevalent internal chemical modification identified to date. Read More

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December 2018

m6A modification of non-coding RNA and the control of mammalian gene expression.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.

The biology of non-coding RNA (ncRNA) and the regulation of mammalian gene expression is a rapidly expanding field. In this review, we consider how recent advances in technology, enabling the precise mapping of modifications to RNA transcripts, has provided new opportunities to dissect post-transcriptional gene regulation. With this has come the realisation that in the absence of translation, the modification of ncRNAs may play a fundamental role in their regulation, protein interactome and subsequent downstream effector functions. Read More

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December 2018

Modulation of vitamin D signaling by the pioneer factor CEBPA.

Biochim Biophys Acta Gene Regul Mech 2018 Dec 11. Epub 2018 Dec 11.

School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland. Electronic address:

The myeloid master regulator CCAAT enhancer-binding protein alpha (CEBPA) is known as a pioneer factor. In this study, we report the CEBPA cistrome of THP-1 human monocytes after stimulation with the vitamin D receptor (VDR) ligand 1α,25-dihydroxyvitamin D (1,25(OH)D) for 2, 8 and 24 h. About a third of the genomic VDR binding sites co-located with those of CEBPA. Read More

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December 2018
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Comparison of stool examination techniques to detect Opisthorchis viverrini in low intensity infection.

Acta Trop 2018 Dec 11. Epub 2018 Dec 11.

Department of Parasitology, Phramongkutklao College of Medicine, Bangkok, 10400, Thailand. Electronic address:

Opisthorchiasis, caused by Opisthorchis viverrini, remains the public health significance in Thailand, particularly in the northeastern region. Number of parasitological techniques is available for diagnosis. However, the detection the parasite's eggs in stool still referred as gold standard. Read More

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December 2018

The cytochrome b lysine 329 residue is critical for ubihydroquinone oxidation and proton release at the Q site of bacterial cytochrome bc.

Biochim Biophys Acta Bioenerg 2018 Dec 11. Epub 2018 Dec 11.

Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

The ubihydroquinone:cytochrome (cyt) c oxidoreductase (or cyt bc) is an important enzyme for photosynthesis and respiration. In bacteria like Rhodobacter capsulatus, this membrane complex has three subunits, the iron‑sulfur protein (ISP) with its FeS cluster, cyt c and cyt b, forming two catalytic domains, the Q (hydroquinone (QH) oxidation) and Q (quinone (Q) reduction) sites. At the Q site, the electron transfer pathways originating from QH oxidation are known, but their associated proton release routes are less well defined. Read More

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December 2018

Polymorphisms in the myeloid differentiation primary response 88 pathway do not explain low expression levels in sudden infant death syndrome.

Acta Paediatr 2018 Dec 14. Epub 2018 Dec 14.

Department of Forensic Sciences, Section of Paediatric Forensic Medicine, Oslo University Hospital, Oslo, Norway.

Aim: The aim of this study was to investigate if a range of known rare and common genetic variants in the Toll-like receptor 4 (TLR4) / myeloid differentiation primary response 88 (MyD88) pathway were present or overrepresented in sudden infant death syndrome (SIDS) compared to controls.

Methods: Genetic variations in the genes encoding TLR4, MyD88 and Interleukin-1 receptor-associated kinase 4 were analysed. The subjects investigated included 158 SIDS cases with a median age of 15. Read More

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December 2018

[Iatrogenic femoral head fracture during a closed reduction of posterior dislocation of hip. Case report].

Acta Ortop Mex 2018 Jul-Aug;32(4):234-239

Servicio de Cadera y Pelvis del Hospital General de Querétaro. Querétaro, México.

The fracture dislocation of the hip is a rare lesion described up to 4 to 17% of the cases and usually secondary to automobile accidents. Generally of poor prognosis and with already well documented complications such as avascular necrosis of the femoral head, osteoarthritis and heterotopic ossification. The iatrogenic fracture of the neck or head of the proximal femur is a complication even more rare and is not documented its incidence in the world literature. Read More

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December 2018

[Parathyroid carcinoma: diagnosis by a femur fracture].

Acta Ortop Mex 2018 Jul-Aug;32(4):229-233

Departamento de Anatomopatología del Hospital Ángeles León. León, Guanajuato. México.

Background: Carcinoma of the parathyroid gland (PC) described by De Quervain since 1909, it represents the least common neoplasm, with an incidence of 1,25/10,000,000 peoples. It has been reported approximately 1,000 cases of CP in world literature. There are two series in Mexico, one of eight patients and other with four cases. Read More

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December 2018
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[Tumor hip prosthesis in fibrous dysplasia of proximal femur. Case report].

Acta Ortop Mex 2018 Jul-Aug;32(4):225-228

Unidad Médica de Alta Especialidad del Hospital de Traumatología y Ortopedia de Puebla del Instituto Mexicano del Seguro Social. Puebla, México.

Background: fibrous dysplasia is characterized by the formation of fibrous tissue that generates immature malformed trabeculae. Their involvement may be monostotic or poliostotic.

Case Report: Thirty years old female with fibrous dysplasia of the left hip. Read More

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December 2018

[The 50 most cited articles in orthopedics and traumatology by Mexican authors].

Acta Ortop Mex 2018 Jul-Aug;32(4):214-224

Departamento de Ortopedia. Centro Médico ABC, Ciudad de México, México.

Background: The amount of quotation a scientific article receives is important for the academic impact. In the present study, we analyzed the 50 most cited articles in orthopedics and related areas published by mexican authors, as well as analyzing their main characteristics.

Material And Methods: A search was conducted using Web of Science, of the 50 articles with the largest number of quotation on orthopedics and related areas, in which the principal author or corresponding author had an address in Mexico. Read More

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December 2018

[Morphological and dimensional changes of the magnetic resonance imaging in the carpal tunnel (pre- and postoperatively)].

Acta Ortop Mex 2018 Jul-Aug;32(4):209-213

Unidad Médica de Alta Especialidad de Traumatología y Ortopedia «Lomas Verdes» del Instituto Mexicano del Seguro Social (IMSS). México.

Introduction: Carpal tunnel syndrome is the most common compression neuropathy of the upper limb, and the release of the median nerve is the surgical treatment that is carried out. There are several surgical techniques used to treat this condition; However, this virtual cavity, which we call the carpal tunnel, undergoes several morphological and dimensional changes, prior to surgery and after surgery using the various techniques that the surgeon has a predilection for.

Material And Methods: Observational, prospective and longitudinal study conducted in the period from March to November 2009. Read More

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December 2018

Comparative study between Plate-Graff, Plate-Cage and peek cage in cervical spine fusion.

Acta Ortop Mex 2018 Jul-Aug;32(4):203-208

Spine Surgery Service. National Institute of Rehabilitation Luis Guillermo Ibarra Ibarra. Mexico City. Mexico.

Objective: To compare results of Plate-Graff, Plate-Cage and PEEK cage in patients with cervical stenosis.

Material And Methods: Prospective, with before and after intervention and comparative study. From January 2005 to October 2011 we included 37 patients (male: 48. Read More

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December 2018

[Leucocyte esterase as a reliable diagnostic, cost-effective and fast in knee infections].

Acta Ortop Mex 2018 Jul-Aug;32(4):198-202

Dirección de Educación e Investigación en Salud, Hospital de Traumatología. Unidad Médica de Alta Especialidad (UMAE). «Dr. Victorio de la Fuente Narváez», Instituto Mexicano del Seguro Social (IMSS). Ciudad de México. México.

Background: The articular infection represents a challenge due to its complexity and its devastating effect when not treated promptly. We have various diagnostic studies: cultures, ESR, CRP, count of leukocytes, among others but none is specific, it takes more than 30 minutes to complete and require complex infrastructure. In this study we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. Read More

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December 2018

Preoperative serum albumin as a predictor of complications following total hip replacement in patients with rheumatoid arthritis.

Acta Ortop Mex 2018 Jul-Aug;32(4):193-197

Trauma and Orthopaedic Surgery Hospitals. UMAE «Dr. Victorio de la Fuente Narváez», Mexico City.

Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by polyarthritis with progressive articular wear, immunologic abnormalities and increasing physical limitation. Surgical correction with hip replacement comes as a successful solution for patients with advanced articular destruction. Following intervention, surgical site infection (SSI), venous thromboembolism, sepsis, renal and major cardiovascular complications are among the most cited in the literature. Read More

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December 2018

Optic Disc Coloboma in children - prevalence, clinical characteristics and associated morbidity.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Purpose: The aim of the study was to report prevalence, ocular outcome, neurological characteristics, cognitive and behavioural problems in children with optic disc coloboma (ODC).

Methods: This was a population-based, cross-sectional study of 31 children between 2 and 18 years of age diagnosed with ODC. The children were part of a larger cohort of 184 children with congenital optic disc malformations. Read More

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December 2018
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Retinal metabolic and structural alterations in response to aflibercept treatment in neovascular age-related macular degeneration.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Odense University Hospital, Odense, Denmark.

Purpose: Non-invasive retinal markers of disease activity could pave the way for individualized treatment in neovascular age-related macular degeneration (nAMD). We aimed to evaluate if retinal vascular oxygen saturation and calibres could predict the initial treatment response after a loading phase of intravitreal aflibercept in nAMD.

Method: A total of 149 eyes were included (nAMD, n = 76; dry AMD, n = 30; normal eyes n = 43). Read More

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December 2018

Repeatability and reliability of quantitative fundus autofluorescence imaging in patients with early and intermediate age-related macular degeneration.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology and Optometry, Vienna Trial Center (VTC), Medical University of Vienna, Vienna, Austria.

Purpose: Quantification of fundus autofluorescence has only recently become available. We report our findings on the evaluation of the repeatability and reliability of quantitative fundus autofluorescence (qAF) measurements in patients with early and intermediate age-related macular degeneration (AMD), using the first approved and commercially available instrument.

Methods: A total of 43 eyes of 22 patients (aged between 52 and 84 years) diagnosed with early and intermediate AMD were included. Read More

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December 2018

Review of rodent hypertensive glaucoma models.

Acta Ophthalmol 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong.

Glaucoma is a neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) is a primary risk factor for the development and progression of glaucoma. Rodent models of glaucoma have greatly improved our understanding of the pathophysiology of glaucoma and served as a useful tool to investigate neuroprotective agents. Read More

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December 2018

Hemofiltration for neuroprotection in acute ischemic stroke: a prospective, pilot study.

Acta Neurol Scand 2018 Dec 13. Epub 2018 Dec 13.

National Research Oncology and Transplantation Center, Astana, Kazakhstan.

Background: Hemofiltration reduces blood levels of cytokines, glutamate and other substances that increase the risk of stroke-associated neurodegeneration. This study aimed to assess the safety and efficacy of hemofiltration in acute ischemic stroke patients.

Methods: 37 patients (mean age 56±16 years) who had an ischemic stroke within the previous 12 hours were randomized to receive hemofiltration for 36 hours (n=19) or standard treatment (n=18). Read More

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December 2018
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Rotavirus vaccine for neonates.

Acta Paediatr 2018 Dec 12. Epub 2018 Dec 12.

The Royal Women's Hospital, Melbourne, Australia.

Rotavirus is a leading cause of morbidity and mortality for neonates and children. Worldwide, over 200,000 children die from rotavirus gastroenteritis each year and more than 90 million infants still lack access to a rotavirus vaccine. Traditional vaccine schedules administer doses at 8 weeks, 14 weeks and 18 weeks of age. Read More

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December 2018

Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis.

Oral Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam Cancer Center Amsterdam, Amsterdam, the Netherlands.

Objectives: The aim of the present study was to assess the outcomes of radical and conservative treatment approaches of solid/multicystic and unicystic ameloblastoma in terms of recurrence rates.

Material And Methods: A systematic review and meta-analysis was conducted based on the PRISMA statement. Search was performed using PubMed, Embase, SCOPUS, and Web of Science for articles published from January 1969 until March 2018. Read More

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December 2018

The association between subjective maternal stress during pregnancy and offspring clinically diagnosed psychiatric disorders.

Acta Psychiatr Scand 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology, Royal College of Surgeons in Ireland, Dublin.

Objective: Exposure to prenatal stress is a ubiquitous and non-specific risk factor for adverse outcomes in adulthood. In this study, we examined associations between exposure to subjective maternal stress during pregnancy and subsequent diagnosis of psychiatric disorders in offspring.

Method: This study used the Helsinki Longitudinal Temperament Cohort, a prospective birth cohort of individuals born between July 1st, 1975 and June 30th, 1976 in Helsinki, Finland. Read More

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December 2018

When Lightning Strikes in Pregnancy: Response Letter.

Authors:
Jessie R Maxwell

Acta Paediatr 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics and Neurosciences, University of New Mexico, Albuquerque, NM, USA.

Thank you so much for your insightful comments (1) in response to our Brief Report (2) recently published in which we discuss maternal lightning strikes during pregnancy, and the impact this can have on the developing fetus. One of the main points discussed in your letter was our choice to include data on electrical injuries during pregnancy. Due to the brief nature of this communication, the number of references we could provide was very limited. Read More

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December 2018

The role of the sapovirus infection increased in gastroenteritis after national immunisation was introduced.

Acta Paediatr 2018 Dec 12. Epub 2018 Dec 12.

Vaccine Research Center, University of Tampere, Tampere, Finland.

Aim: This study examined the prevalence and clinical significance of the sapovirus infection in children with acute gastroenteritis before and after the introduction of the rotavirus vaccination in Finland in 2009.

Methods: We collected 1,437 stool samples from children under 16 years during three prospective hospital-based surveillance studies of acute gastroenteritis at Tampere University Hospital, Finland. The children were seen in the emergency department (47%) or admitted to the ward (53%). Read More

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December 2018

The Swedish shaken baby syndrome report and review: what does the latest knowledge tell us?

Authors:
Marta C Cohen

Acta Paediatr 2018 Dec 12. Epub 2018 Dec 12.

Sheffield Children's Hospital NHS FT, Sheffield, UK.

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December 2018

Reversal of mivacurium-induced neuromuscular blockade with a cholinesterase inhibitor: A systematic review.

Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.

Department of Anaesthesiology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.

Background: Mivacurium is a short-acting non-depolarizing muscle relaxant, which is hydrolyzed by butyrylcholinesterase. The neuromuscular block (NMB) can be antagonized with cholinesterase inhibitors (CHEI), but the short duration of action of mivacurium questions the need. This systematic review evaluated if the use of CHEIs (neostigmine, pyridostigmine or edrophonium) facilitates reversal of mivacurium-induced NMB. Read More

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December 2018

Remote ischaemic preconditioning increases serum extracellular vesicle concentrations with altered micro-RNA signature in CABG patients.

Acta Anaesthesiol Scand 2018 Dec 11. Epub 2018 Dec 11.

Klinik für Anästhesiologie und Intensivmedizin, Universitätsklinikum Essen, Universität Duisburg-Essen, Essen, Germany.

Background: Remote ischaemic preconditioning (RIPC) can attenuate myocardial ischaemia/reperfusion injury but its underlying mechanisms remain largely unknown. Recently, extracellular vesicles (EVs) containing microRNAs (miRNAs) were shown to mediate distant intercellular communication that may be involved in cardioprotection. We tested the hypothesis that RIPC in anaesthetized patients undergoing coronary artery bypass (CABG) surgery results in the release of EVs from the ischaemic/reperfused arm into the blood stream harbouring cardioprotective miRNAs. Read More

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December 2018

Conjunctival melanoma and electrochemotherapy: preliminary results using 2D and 3D cell culture models in vitro.

Acta Ophthalmol 2018 Dec 10. Epub 2018 Dec 10.

Liverpool Ocular Oncology Research Group, Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Purpose: To investigate the cytotoxic effect of bleomycin, mitomycin C (MMC) and Fluorouracil (5-FU) in combination with electroporation (EP) on human conjunctival melanoma (CM) and normal conjunctival cell lines using 2D and 3D cell culture systems in vitro.

Methods: Two CM (CRMM1, CRMM2) and one normal conjunctival epithelial cell line (HCjE-Gi) were treated with various EP conditions and increasing concentrations of 5-FU, MMC and bleomycin. Cell survival was assessed by MTT viability assay. Read More

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December 2018

Eotaxins and C-C chemokine receptor type 3 in Parkinson's disease.

Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.

Geriatric Care Research Center, Rafsanjan University of Medical Science, Rafsanjan, Iran.

Parkinson's disease (PD) is one of the most common neuroinflammatory disorders and inflammatory processes seem to play an important role in the pathogenesis of PD. Chemokines as inflammatory mediators, which are involved in the recruitment of leukocytes, can play a role in the pathogenesis of PD. The aim of this study was to examine the serum level of eotaxins (CCL11, CCL24, and CCL26) and the expression of C-C chemokine receptor type 3 (CCR3) in patients with PD compared with healthy subjects. Read More

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December 2018

Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome.

Acta Neurol Belg 2018 Dec 13. Epub 2018 Dec 13.

Physical Medicine and Rehabilitation Clinic, Bingöl State Hospital, Bingöl, Turkey.

Objective: A high prevalence of obesity in fibromyalgia syndrome (FMS) predisposes patients to metabolic changes. It is not clear how the clinical manifestations of the disease affect metabolism. This study aimed to investigate leptin, growth hormone (GH), and insulin-like growth factor (IGF-1) levels in FMS, and their relationship with body mass index (BMI) and disease severity. Read More

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December 2018

Efficiency and complications of Woven EndoBridge (WEB) devices for treatment of larger, complex intracranial aneurysms-a single-center experience.

Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.

Institute of Clinical Medicine, University in Oslo, Problemveien 17, 0315, Oslo, Norway.

Background: Several recently published multicenter studies have reported high treatment feasibility, high safety, and good 6-month to 1-year efficiency when treating smaller intracranial aneurysms (IA) with WEB deployment. The purpose of the study was to evaluate the long-term efficiency and complications related to WEB treatment of larger, complex intracranial aneurysms in a small single-center cohort.

Methods: Patients with ruptured and unruptured IA were treated with WEB devices; data were collected prospectively and analyzed retrospectively. Read More

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December 2018
2 Reads

Correction to: Intracranial foreign material granuloma after neurosurgical procedures.

Acta Neurochir (Wien) 2018 Dec 13. Epub 2018 Dec 13.

Department of Neurosurgery, Hannover Medical School, Carl-Neuberg Str. 1, 30625, Hanover, Germany.

Incorrect title of the article. Read More

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December 2018

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer's disease.

Acta Neuropathol 2018 Dec 13. Epub 2018 Dec 13.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborgsvägen 31, House V3/SU, 43180, Mölndal, Sweden.

Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer's disease (AD). Most of tau in CSF is present as fragments. Read More

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December 2018
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Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

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December 2018

Energy Dispersive X-Ray Fluorescence Zn/Fe Ratiometric Determination of Zinc Levels in Expressed Prostatic Fluid: A Direct, Non-Invasive and Highly Accurate Screening for Prostate Cancer.

Acta Sci Cancer Biol 2018 Nov 10;2(9):20-26. Epub 2018 Oct 10.

The Department of Oncology and Diagnostic Sciences, University of Maryland School of Dentistry, Maryland, United States of America.

Prostate specific antigen (PSA) does not provide the reliability that is required for the accurate urology screening of prostate cancer (PCa). Consequently, there has been a major focus and search for a simple, rapid, direct, preferably non-invasive, and highly accurate biomarker and procedure for the urology screening for prostate cancer. Virtually all PCa cases exhibit a marked decrease in zinc in prostate tissue and in prostatic fluid. Read More

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November 2018

T-plate fixation for unstable proximal clavicula fractures.

Acta Orthop Traumatol Turc 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthopaedics, Ningbo, People's Republic of China.

Objective: The aim of this study was to evaluate the clinical results of T-plate fixation and anterior sternoclavicular ligament repair in proximal clavicle fractures.

Methods: Between August 2013 and August 2016, a total 12 patients (10 men and 2 women; mean age: 44.1 ± 9. Read More

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December 2018
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Subglottic stenosis due to chronic lymphocytic leukemia.

Acta Otorrinolaringol Esp 2018 Dec 10. Epub 2018 Dec 10.

Department of Otolaryngology, Toranomon Hospital, Tokyo Japan.

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December 2018
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Progression of carotid artery disease could stratify a risk of coronary artery disease patients with type 2 diabetes.

Acta Biochim Biophys Sin (Shanghai) 2018 Dec 13. Epub 2018 Dec 13.

Institute for Health and Sport, Victoria University, Melbourne VIC, Australia.

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December 2018
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A novel detection method of Cryptosporidium parvum infection in cattle based on Cryptosporidium parvum virus 1.

Acta Biochim Biophys Sin (Shanghai) 2018 Dec 13. Epub 2018 Dec 13.

Key Laboratory of Zoonosis by Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Cryptosporidium parvum is an important zoonotic parasite that causes significant economic loss in the animal husbandry industry, especially the cattle industry. As there is no specific vaccine or drug against Cryptosporidium, a rapid and accurate method for the detection of C. parvum is of great significance. Read More

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December 2018

Advanced glycation end products of bovine serum albumin affect the cell growth of human umbilical vein endothelial cells via modulation of MEG3/miR-93/p21 pathway.

Acta Biochim Biophys Sin (Shanghai) 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiac Surgery, Ruijin Hospital, Shanghai, China.

Advanced glycation end products of BSA (AGE-BSA) contribute to the pathogenesis of diabetic vascular diseases. However, the roles and underlying mechanisms of AGE-BSA in diabetic vascular diseases remain largely unclear. Long non-coding RNAs (lncRNAs) are widely identified and known as gene regulators. Read More

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December 2018
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