1,900 results match your criteria Acta Cirurgica Brasileira[Journal]


Differences in lipidomics may be potential biomarkers for early diagnosis of pancreatic cancer.

Acta Cir Bras 2020 Jul 6;35(5):e202000508. Epub 2020 Jul 6.

MD, Department of General Surgery, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China. Acquisition, analysis and interpretation of data; technical procedures; critical revision; manuscript preparation, final approval.

Purpose: To analyze the plasma lipid spectrum between healthy control and patients with pancreatic cancer and to select differentially expressed tumor markers for early diagnosis.

Methods: In total, 20 patents were divided into case group and healthy control group according to surgical pathology. Of almost 1206 plasma lipid molecules harvested from 20 patients were measured by HILIC using the normal phase LC/MS. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000008DOI Listing

Evaluation of wound healing effect of alginate film containing Aloe vera gel and cross-linked with zinc chloride.

Acta Cir Bras 2020 Jul 3;35(5):e202000507. Epub 2020 Jul 3.

PhD, Associate Professor, Department of Pharmaceutical Science, UEPG, Ponta Grossa-PR, Brazil. Design of the study, technical procedures, interpretation of data, manuscript writing, critical revision, final approval.

Purpose: To develop a new wound dressing composed of alginate and Aloe vera gel and cross-linked with zinc ions.

Methods: The aloe-alginate film was characterized using scanning electron microscopy (SEM), swelling profile, mechanical properties, polysaccharide content and X-ray diffraction (XRD). Thirty Wistar rats were divided in two groups a) treated with aloe-alginate film and b) control (treated with sterile gauze). Read More

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http://dx.doi.org/10.1590/s0102-865020200050000007DOI Listing

Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats.

Acta Cir Bras 2020 Jul 3;35(5):e202000506. Epub 2020 Jul 3.

PhD, Full Professor, Department of Urology, Renmin Hospital of Wuhan University, Wuhan, China. Design and supervised all phases of the study, critical revision, final approval.

Purpose: To examine effects of resveratrol on renal ischemia/ reperfusion injury (I/R) in a streptozotocin (STZ)-induced diabetic rat model.

Methods: Twenty-four male Sprague Dawley rats were treated with STZ injection for the development of diabetes, and divided into the following groups: Sham group, I/R group and Resveratrol group (n=8). Resveratrol (RSV) was administered at a dose of 10 mg. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000006DOI Listing

The influence of platelet-rich plasma (PRP) on colonic anastomosis healing impaired by intraperitoneal 5-flourouracil application. An experimental study.

Acta Cir Bras 2020 Jul 6;35(5):e202000504. Epub 2020 Jul 6.

MD, Department of General Surgery, University of Health Sciences Adana City Training and Research Hospital, Adana, Turkey. Acquisition of data.

Purpose: 5-flourourasil (5-FU) is commonly used for early intraperitoneal chemotherapy in colorectal or appendiceal cancer patients with peritoneal carcinomatosis. Due to its effect, anastomosis healing can be impaired and leads to anastomotic leakage. In this study, we aimed to investigate the potential healing effect of platelet-rich plasma (PRP) on colonic anastomosis impaired by intraperitoneal 5-flourouracil application. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000004DOI Listing

Changrui enema inhibits inflammation-induced angiogenesis in acute radiation proctitis by regulating NF-κB and VEGF.

Acta Cir Bras 2020 Jul 6;35(5):e202000502. Epub 2020 Jul 6.

Full Professor, Department of Oncology, Shanxi Province Research Institute of Traditional Chinese Medicine, Taiyuan, China. Conception and design of the study, provision of reagents, materials and analysis tools.

Purpose: Changrui enema, a traditional Chinese medicine prescription, is used as a supplementary treatment for acute radiation proctitis (ARP). Herein we explored the inhibition effects of Changrui enema on NF-κB and VEGF in ARP mice.

Methods: A total of 120 C57BL/6 mice were divided randomly into normal mice group, ARP mice group, western medicine enema group (dexamethasone combined with gentamicin), and Changrui enema group. Read More

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The feasibility and effectiveness of thoracoscopic transdiaphragmatic approach for lung biopsy in rabbits. A randomized study.

Acta Cir Bras 2020 Jul 3;35(5):e202000501. Epub 2020 Jul 3.

PhD, Full Professor, Department of Veterinary Surgery, FCAV, UNESP, Jaboticabal-SP, Brazil. Conception, intellectual and scientific content of the study; critical revision.

Purpose: To assess the feasibility of thoracoscopic transdiaphragmatic approach for biopsy of all lung lobes and to determine the optimal intercostal space (ICS) for biopsy of each lung lobe.

Methods: Ten rabbits were positioned in dorsal recumbency. Total thoracoscopy lung biopsy was made combined transdiaphragmatic approach and right ICS approaches. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000001DOI Listing

Safety and effectiveness of laparoscopic Y-en-Roux gastric bypass surgery in obese elderly patients.

Acta Cir Bras 2020 6;35(6):e202000606. Epub 2020 Jul 6.

Department of Pulmonology, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Paris, France.

Purpose To analyze, in aged obese patients, the weight loss, comorbidity control, and safety postoperative complications of bariatric surgery by Roux-en-Y gastric bypass technique. Methods Twenty-seven patients who underwent laparoscopic weight-reducing gastroplasty with Roux-en-Y gastric bypass to treat obesity were included. All patients were ≥ 60 years old at the time of surgery. Read More

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http://dx.doi.org/10.1590/s0102-865020200060000006DOI Listing

The effect of rosmarinic acid on deformities occurring in brain tissue by craniectomy method. Histopathological evaluation of IBA-1 and GFAP expressions.

Acta Cir Bras 2020 19;35(4):e202000406. Epub 2020 Jun 19.

PhD, Professor, Department of Anatomy , Faculty of Medicine , Dicle University , Diyarbakır , Turkey . Technical procedures, histopathological examinations, manuscript preparation and writing, final approval.

Purpose: To investigate the role of Rosmarinic acid (RA) in the prevention of traumatic brain injury and the immunohistochemical analysis of IBA-1 and GFAP expressions.

Methods: Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows; control group, traumatic brain injury (TBI) group, and TBI+RA group. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307720PMC

Hepathic, biochemical, hematological, and histological effects of the ultracavitation in rabbits livers.

Acta Cir Bras 2020 19;35(4):e202000403. Epub 2020 Jun 19.

Graduate student, Faculty of Medicine, UnP, Natal-RN, Brazil. Manuscript preparation.

Purpose: To collect data capable of pointing out the effects of the ultracavitation treatment on the liver of rabbits after adipose tissue application, by means of histological analyses of the liver and hematological and biochemical exams.

Methods: This is an experimental study with 12 albino rabbits as sample, which were divided into 3 groups and submitted to a hypercaloric diet for one month. Subsequently, subjects underwent UCV treatment: 3 minutes, 30 W, continuous mode at 100%, every 2 ERAS = 441. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307718PMC

Effects of bradykinin preconditioning in an experimental intestinal ischemia reperfusion model on rats.

Acta Cir Bras 2020 19;35(4):e202000402. Epub 2020 Jun 19.

MD, Department of General Surgery, Erciyes University Medical Faculty, Melikgazi, Kayseri, Turkey. Conceptıon and design of the study, technical procedures, manuscript writing, critical revision.

Purpose: To investigate the effects of bradykinin on reperfusion injury in an experimental intestinal ischemia reperfusion model.

Methods: We used 32 Wistar-Albino rats. We composed 4 groups each containing 8 rats. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307719PMC

Diagnostic accuracy of 18F-FDG-PET in abdominal sepsis in rats.

Acta Cir Bras 2020 22;35(5):e202000505. Epub 2020 Jun 22.

PhD, Full Professor, Nucleus of Experimental Surgery, UFRN, Natal-RN, Brazil. Conception, design, intellectual and scientific content of the study; critical revision; final approval.

Purpose: The objective of this study was to investigate the accuracy of 18F-FDG-PET in the diagnosis of multibacterial abdominal sepsis by cecum ligation and puncture (CLP) in rats.

Methods: Adult Wistar rats ( Rattus norvegicus ), weighing 227±35g, were allocated into a sepsis group by CLP (n=10) and sham group (n=10). 18F-FDG-PET using microPET was performed on all rats after 24 hours. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310585PMC

Effect of preconditioning and postoperative hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats.

Acta Cir Bras 2020 22;35(5):e202000503. Epub 2020 Jun 22.

PhD, Associate Professor, Division of Surgery, School of Medicine, UnB, Brasilia-DF, Brazil. Conception and design of the study; acquisition, analysis and interpretation of data; manuscript preparation and writing; critical revision, final approval.

Purpose: To investigate the effect of hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats.

Methods: Forty female rats underwent segmental resection of 1 cm of the left colon followed by end-to-end anastomosis. They were randomly assigned to four groups (n=10 each), a sham group; two groups were submitted to Hyperbaric Oxygen therapy (HBOT) with and without induced ischemia and the induced ischemia group without HBOT. Read More

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http://dx.doi.org/10.1590/s0102-865020200050000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310584PMC

Randomized, double-blind, placebo-controlled study of the analgesic effect of intraoperative esmolol for laparoscopic gastroplasty.

Acta Cir Bras 2020 5;35(4):e202000408. Epub 2020 Jun 5.

PhD, Pain Sector, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Manuscript writing, final approval.

Purpose: To evaluate the analgesic effect of esmolol in patients submitted to laparoscopic gastroplasty.

Methods: Forty patients aged between 18 and 50 years with American Society of Anesthesiologists (ASA) physical status scores of II and III who underwent gastric bypass were allocated to two groups. Group 1 patients received a 0. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000008DOI Listing

Comparative clinical evaluation of breast augmentation using silicone foam coated implants and textured implants.

Acta Cir Bras 2020 5;35(4):e202000407. Epub 2020 Jun 5.

Full Professor and Chairman, Division of Plastic Surgery, UNICAMP, Campinas-SP, Brazil. Scientific, intellectual, conception and design of the study; analysis and interpretation of data; technical procedures; manuscript preparation; critical revision; final approval.

Purpose: To evaluate whether silicone foam implants have a different evolution pattern compared to conventional texture implants.

Methods: Fifty-eight female patients underwent surgery. They were divided into two groups (silicone foam - Lifesil® - and microtexturized silicone - Lifesil®). Read More

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http://dx.doi.org/10.1590/s0102-865020200040000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292626PMC

Mechanical properties of the sciatic nerve following combined transplantation of analytically extracted acellular allogeneic nerve and adipose-derived mesenchymal stem cells.

Acta Cir Bras 2020 5;35(4):e202000405. Epub 2020 Jun 5.

PhD, Biomechanics, Department of Orthopaedics, China-Japan Union Hospital, Jilin University, China. Technical procedures, analysis of data.

Purpose: To investigate the effects of Chemically Extracted Acellular Nerves (CEANs) when combined with Adipose-Derived mesenchymal Stem Cell (ADSC) transplantation on the repair of sciatic nerve defects in rabbits.

Methods: A total of 71 six-month-old Japanese rabbit were used in this study. Twenty rabbits served as sciatic nerve donors, while the other 51 rabbits were randomly divided into Autologous Nerve Transplantation Group (ANT, n=17), CEAN group (n=17) and CEAN-ADSCs group (n=17). Read More

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http://dx.doi.org/10.1590/s0102-865020200040000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292625PMC

Therapeutic effects of vitamin D on acetic acid-induced colitis in rats.

Acta Cir Bras 2020 5;35(4):e202000404. Epub 2020 Jun 5.

Assistant Professor, Ege University, Faculty of Medicine, Department of Histology and Embryology, Izmir, Turkey. Investigation, manuscript writing, critical revision.

Purpose: To analyze the effect of calcitriol treatment on acute colitis in an experimental rat model.

Methods: A total of 24 adult Sprague Dawley albino rats were randomly separated into 3 equal groups: control group (n:8), colitis group (n:8), calcitriol administered group (n:8). A single dose of acetic acid (1 ml of 4% solution) was administered intrarectally to induce colitis. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292621PMC

Histological analysis of the intestinal wall of newborn rats submitted to hypoxia and reoxygenation to evaluate the protective effect of N-Acetylcysteine.

Acta Cir Bras 2020 5;35(4):e202000401. Epub 2020 Jun 5.

PhD, Division of Pediatric Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, final approval.

Purpose: To evaluate the effect of N-Acetylcysteine (NAC) in newborn rats submitted to hypoxia and reoxygenation (H/R) conditions in an experimental model of necrotizing enterocolitis.

Methods: Eight pregnant rats and their 70 cubs were used (5 groups) and exposed to H/R conditions and received NAC at different times. The animals in the H/R groups were placed in a gas chamber (100% CO2) for 10 minutes and then reoxygenated for 10 minutes (100% O2), twice a day for the first three days of life, with a six-hour span between events. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292620PMC

Encouragement to submit manuscripts-suggestions from a Japanese Associate Editor of Acta Cirurgica Brasileira.

Authors:
Eiji Kobayashi

Acta Cir Bras 2020 2;35(4):e202000400. Epub 2020 Jun 2.

MD, PhD, Department of Organ Fabrication, Keio University School of Medicine, Tokyo, Japan.

Medicine can be broadly divided into two fields: clinical medicine that aims to save existing patients and basic medical research that aims to save the lives of future patients. In terms of disseminating basic medical research, medical journals play a vital role for physicians and scientists, as they enable them to share experiences. The author, who has been serving as an Associate Editor of the Brazilian journal Acta Cirurgica Brasileira over a long period of time, wishes to encourage physicians and researchers to submit their papers to medical journals. Read More

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http://dx.doi.org/10.1590/s0102-865020200040000000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292624PMC

Erratum.

Authors:

Acta Cir Bras 2020 Jun 2;35(4):e202000205err. Epub 2020 Jun 2.

[This corrects the article doi: 10.1590/s0102-865020200020000005]. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000005errDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292622PMC

Morphological and molecular analysis of apoptosis in the corpus cavernosum of rats submitted to a chronic alcoholism model.

Acta Cir Bras 2020 3;35(3):e202000305. Epub 2020 Jun 3.

PhD, Associate Professor, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Final approval.

Purpose: To evaluate the effect of chronic alcoholism on morphometry and apoptosis mechanism and correlate with miRNA-21 expression in the corpus cavernosum of rats.

Methods: Twenty-four rats were divided into two experimental groups: Control (C) and Alcoholic group (A). After two weeks of an adaptive phase, rats from group A received only ethanol solution (20%) during 7 weeks. Read More

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http://dx.doi.org/10.1590/s0102-865020200030000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282493PMC

Decision making process in simultaneous laparoscopic resection of colorectal cancer and liver metastases. Review of literature.

Acta Cir Bras 2020 22;35(3):e202000308. Epub 2020 May 22.

MD, Research Institute against Cancer of the Digestive System, Strasbourg, France. Manuscript writing, critical revision.

Purpose: The benefits of laparoscopic approaches to treat colorectal cancer (CRC) and colorectal liver metastases (CRLM) separately are well established. However, there is no consensus about the optimal timing to approach the primary tumor and CRLM, whether simultaneously or staged. The objective of this review with practical reports is to discuss technical aspects required for patient selection to perform simultaneous laparoscopic approaches for CRC and CRLM. Read More

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http://dx.doi.org/10.1590/s0102-865020200030000008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251979PMC
June 2020
0.570 Impact Factor

Effect of low intensity photobiomodulation associated with norbixin-based poly (hydroxybutyrate) membrane on post-tenotomy tendon repair. In vivo study.

Acta Cir Bras 2020 22;35(3):e202000303. Epub 2020 May 22.

Postgraduate Program in Material Engineering (PPGEM), IFPI, Teresina, PI, Brazil.

Purpose: To evaluate the in vivo response of photobiomodulation therapy associated with norbixin-based poly(hydroxybutyrate) membrane (PHB) in tenotomized calcaneal tendon.

Methods: Thirty rats were randomly allocated to six groups (n=5 each): LED groups (L1, L2 and L3) and membrane + LED groups (ML1, ML2 and ML3). The right calcaneal tendons of all animals were sectioned transversely and were irradiated with LED daily, one hour after surgery every 24 hours, until the day of euthanasia. Read More

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http://dx.doi.org/10.1590/s0102-865020200030000003DOI Listing
June 2020
0.570 Impact Factor

Induction of selective liver hypothermia prevents significant ischemia/reperfusion injury in Wistar rats after 24 hours.

Acta Cir Bras 2020 8;35(2):e202000205. Epub 2020 May 8.

Division of General Surgery, HCPA, UFRGS, Porto Alegre, RS,, Brazil.

Purpose To investigate the effects of induction of selective liver hypothermia in a rodent model. Methods Seven male Wistar rats were subjected to 90 minutes of partial 70% liver ischemia and topic liver 26°C hypothermia (H group). Other seven male Wistar rats were subjected to 90 minutes of partial 70% normothermic liver ischemia (N group). Read More

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http://dx.doi.org/10.1590/s0102-865020200020000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217597PMC

Poly (Lactic Acid) membrane and Sedum dendroideum extract favors the repair of burns in rats.

Acta Cir Bras 2020 11;35(3):e202000302. Epub 2020 May 11.

Centro Universitário, FHO, Araras, SP, Brazil.

Purpose: To evaluate the healing potential of the electrospinning membranes of Poly (Lactic Acid) (PLA) associated with Sedum dendroideum extract in burn injuries in rats.

Methods: Seventy-five rats were submitted to burn injury on their back skin: (C) untreated; (F) with daily topical application of S. dendroideum extract; (M) with electrospinning membranes of PLA; (MF10) with electrospinning membranes of PLA with 10% S. Read More

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http://dx.doi.org/10.1590/s0102-865020200030000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217594PMC

Effects of oxidative stress on liver, brain and spinal cord of rats using L-NAME and treated with hydroxyurea. A model of sickle cell complication.

Acta Cir Bras 2020 8;35(3):e202000301. Epub 2020 May 8.

Postgraduate Program in Health and Development in the Midwest Region, UFMS, Campo Grande, MS, Brazil.

Purpose: To analyze the serum levels of nitric oxide and correlate them with the levels of thiobarbituric acid reactive substances (TBARS) in liver, brain and spinal cord of animals using L-NAME and treated with hydroxyurea.

Methods: Eighteen male albino Wistar rats were divided into three groups. NG-nitro-L-arginine methyl ester (L-NAME) was intraperitoneally administered to induce oxidative stress. Read More

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http://dx.doi.org/10.1590/s0102-865020200030000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217595PMC

Robotic endoscopy. A review of the literature.

Acta Cir Bras 2020 27;35(2):e202000206. Epub 2020 Apr 27.

Department of Surgery, School of Medicine, USP, Sao Paulo, SP, Brazil.

Purpose To present new endoscopic robotic devices in the context of minimally invasive procedures with high precision and automation. Methods Review of the literature by December 2018 on robotic endoscopy. Results We present the studies and investments for robotic implementation and flexible endoscopy evolution. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184939PMC

Remote ischemic conditioning protects against testicular ischemia∕reperfusion injury in rats.

Acta Cir Bras 2020 27;35(2):e202000203. Epub 2020 Apr 27.

Centro Universitário do Estado do Pará, Brazil.

Purpose To evaluate the effect of remote ischemic conditioning associated to N-acetylcysteine (NAC) on testicular ischemia∕reperfusion (I∕R) injury in rats. Methods Twenty-five adult male Wistar rats were randomly distributed into five experimental groups (n=5), as follows: Sham, I∕R, Perconditioning (PER), NAC and PER+NAC. Two-hour ischemia was induced by rotating the left testis 720° to clockwise direction, followed by 4 hours of reperfusion. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184938PMC

Database of the alumni performance of the Ophthalmology Stricto sensu Postgraduate Program at Escola Paulista de Medicina, UNIFESP.

Acta Cir Bras 2020 17;35(2):e202000207. Epub 2020 Apr 17.

PhD, Ophthalmology and Visual Science Department, EPM-UNIFESP, Sao Paulo-SP, Brazil. Scientific and intellectual content of the study, technical procedures, critical revision, final approval.

Purpose: To develop a database with social, demographic and professional information of all graduates of the two post-graduate programs in Ophthalmology of EPM-UNIFESP, including their opinions on quality, application, and contribution of the courses received in their professional careers.

Methods: The survey was conducted in the digital and physical archives of the University and by telephone contact. When the graduates' e-mails were all collected, the electronic questionnaire was applied. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184940PMC

Does a bilateral polypropylene mesh alter the duct deferens morphology, testicular size and testosterone levels? Experimental study in rats.

Acta Cir Bras 2020 17;35(2):e202000201. Epub 2020 Apr 17.

Full Professor, Division of General Surgery and Trauma, Department of Surgery, HC/FMUSP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

Purpose: To evaluate the effect of a PP mesh on duct deferens morphology, testicular size and testosterone levels.

Methods: Forty adult male rats were distributed into groups: 1) no surgery; 2) inguinotomy; 3) mesh placed on the duct deferens; and 4) mesh placed on the spermatic funiculus. After 90 postoperative days, the inguinal region was resected, and blood samples were collected for the measurement of serum testosterone (pg/dl). Read More

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http://dx.doi.org/10.1590/s0102-865020200020000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184941PMC

Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice.

Acta Cir Bras 2020 9;35(2):e202000204. Epub 2020 Apr 9.

Master, Chairman and Head, Department of Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, China. Conception and design of the study, critical revision, supervised all phases of the study.

Purpose: To investigate the effect of growth arrest-specific protein 6 (Gas6) on acute liver injury in mice and related mechanisms.

Methods: Thirty C57BL/6 (6-8 weeks old) mice were randomly divided into control, LPS/D-GalN, and LPS/D-GalN+Gas6 groups (10 mice in each group). The LPS/D-GalN group was intraperitoneally administered with LPS (0. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158606PMC
May 2020
0.570 Impact Factor

TNF-alpha inhibitor adalimumab attenuates endotoxin induced cardiac damage in rats.

Acta Cir Bras 2020 3;35(2):e202000202. Epub 2020 Apr 3.

MD, Department of Medical Biochemistry, Faculty of Medicine, Adnan Menderes University, Aydın, Turkey. Design of the study, acquisition and analysis of data, final approval.

Purpose: To investigate the effects of adalimumab pretreatment on the lipopolysaccharide-mediated myocardial injury.

Methods: Twenty-eight Wistar rats were randomized into four groups (n=7). Control (C) group animals were injected once a day with intraperitoneal (i. Read More

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http://dx.doi.org/10.1590/s0102-865020200020000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7124089PMC

Effects of ATRA on diabetic rats with renal ischemia-reperfusion injury.

Acta Cir Bras 2020 27;35(1):e202000106. Epub 2020 Mar 27.

PhD, Department of Anesthesiology, People's Hospital of Wuhan University, Wuhan, Hubei, China. Acquisition and analysis of data.

Purpose: To explore the role of all-trans retinoic acid (ATRA) in renal ischemia/reperfusion injury of diabetic rats.

Methods: Sixty adult male rats were randomly divided into 6 groups, including sham group (S group), ischemia-reperfusion group (I/R group), ischemia-reperfusion+ATRA group (A group), diabetic group (D group), diabetic ischemia-reperfusion group (DI/R group), diabetic ischemia-reperfusion +ATRA group (DA group). The levels of creatinine (Cr), cystatin C (Cys-C) and β2-microglobulin (β2-MG) were measured. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106780PMC

Involvement of HSP90 in ischemic postconditioning-induced cardioprotection by inhibition of the complement system, JNK and inflammation.

Acta Cir Bras 2020 20;35(1):e202000105. Epub 2020 Mar 20.

MD, Geriatric Health Care Center, First Affiliated Hospital, Guang Xi Medical University, China. Critical revision.

Purpose: To investigate whether heat shock protein 90 (HSP90) is involved in complement regulation in ischemic postconditioning (IPC).

Methods: The left coronary artery of rats underwent 30 min of occlusion, followed by 120 min of reperfusion and treatment with IPC via 3 cycles of 30s reperfusion and 30s occlusion. The rats were injected intraperitoneally with 1 mg/kg HSP90 inhibitor geldanamycin (GA) after anesthesia. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092678PMC

The protective effect of Ganoderma lucidum on testicular torsion/detorsion-induced ischemia-reperfusion (I/R) injury.

Acta Cir Bras 2020 20;35(1):e202000103. Epub 2020 Mar 20.

MD, Hitit University Erol Olcok Training and Research Hospital , Department of Pediatric Surgery , Çorum , Turkey . Acquisition of data, manuscript preparation.

Purpose: To investigate the protective effect of Ganoderma lucidum on testicular torsion/detorsion (T/D)-induced ischemia-reperfusion (I/R) injury.

Methods: Thirty male Wistar albino rats were randomly categorized into 3 groups: Group 1: sham, Group 2 ( T/D): 2,5 hours of ischemia and 7 days of reperfusion, Group 3 (T/D+ G. lucidum ): 2,5 hours of ischemia and 7 days of reperfusion and 7 days of 20 mg/kg via gastric gavage G. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092665PMC

Local effect of simvastatin combined with different osteoconductive biomaterials and collagen sponge on new bone formation in critical defects in rat calvaria.

Acta Cir Bras 2020 20;35(1):e202000102. Epub 2020 Mar 20.

Associate Professor, Postgraduate Program in Medical Sciences , School of Medicine , UnB , Brasilia - DF , Brazil ,. Design, intellectual and scientific content of the study.

Purpose: To evaluate the local effect of simvastatin (SVT) combined with deproteinized bovine bone (DBB) with hydroxyapatite/β-tricalcium phosphate biphasic ceramics (HA/TCP) and with collagen sponge (CS) on bone repair in critical size defects (CSDs) in rat calvaria.

Methods: Forty-two 5-mm diameter CSDs were made bilaterally in the calvaria of 18 rats. The animals were allocated according to the type of biomaterial and associations used to fill the CSD. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092666PMC

Role of adiponectin in diabetes myocardial ischemia-reperfusion injury and ischemic postconditioning.

Acta Cir Bras 2020 23;35(1):e202000107. Epub 2020 Mar 23.

PhD, Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China. Scientific and intellectual content of the study, statistical analysis, final approval.

Purpose: Patients with diabetes are vulnerable to myocardial I/R (ischaemia/reperfusion) injury, but are not responsive to IPO (ischaemic post-conditioning). We hypothesized that decreased cardiac Adiponectin (APN) is responsible for the loss of diabetic heart sensitivity to IPO cardioprotecton.

Methods: Diabetic rats were subjected to I/R injury (30 min of LAD occlusion followed by 120 min of reperfusion). Read More

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http://dx.doi.org/10.1590/s0102-865020200010000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092667PMC
May 2020
0.570 Impact Factor

Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats.

Acta Cir Bras 2020 9;35(1):e202000104. Epub 2020 Mar 9.

MD, Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. Conception and design of the study, analysis and interpretation of data, critical revision,final approval.

Purpose: Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important intestinal mucosa protectant in clinical practice and experimental research. However, the mechanisms of its protective effects are still not fully understand. Consequently, this study aimed to explore the potential mechanism of glutamine on ischemia-reperfusion (I/R) injury induced endoplasmic reticulum (ER) stress in intestine. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065443PMC
March 2020
0.570 Impact Factor

Original and generic preservation solutions in organ transplantation. A new paradigm?

Acta Cir Bras 2020 9;35(1):e202000101. Epub 2020 Mar 9.

PhD, Centre Hépatobiliare, AP-HP Hôpital Paul Brousse, Inserm U935, Université Paris-Sud, Villejuif, France. Manuscript writing, final approval.

Solid organ transplantation is a very complex process, in which the storage of the graft in a preservation solution is mandatory in order to extend ischemic times and contain further damage. The condition in which the organ is transplanted is critical for the outcome of the organ recipient. The recent emergence of generic versions of organ preservation solutions (solutions with the same composition and under the same legislation as the original versions, but with different brands) compelled us to study whether the standards are maintained when comparing the original and its generic counterpart. Read More

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http://dx.doi.org/10.1590/s0102-865020200010000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065442PMC

Therapeutic effect of adenosine on experimentally induced acute ulcerative colitis model in rats.

Acta Cir Bras 2020 14;34(12):e201901204. Epub 2020 Feb 14.

MD, Department of Physiology, Faculty of Medicine of Demiroglu Bilim University, Istanbul, Turkey. Conception and design of the study, statistics analysis, manuscript preparation and writing, critical revision, final approval.

Purpose: To examine the therapeutic effect of external adenosine on an acetic acid-induced acute ulcerative colitis model in rats.

Methods: Thirty male mature rats were divided into three groups as control, acute colitis (AC) and AC+adenosine group (AC+AD). AC was induced by rectal administration of 4% acetic acid (AA). Read More

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http://dx.doi.org/10.1590/s0102-865020190120000004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7025795PMC

Chorioallantoic urothelial tumor avatar. A clinical tool for phenotype-based therapy.

Acta Cir Bras 2020 10;34(12):e201901207. Epub 2020 Feb 10.

MD, MSc, PhD, UroScience, Department of Urology, School of Medical Sciences, UNICAMP, and.

In the muscle invasive bladder cancer (MIBC) standard of care treatment only patients presenting a major pathological tumor response are more likely to show the established modest 5% absolute survival benefit at 5 years after cisplatin-based neoadjuvant chemotherapy (NAC). To overcome the drawbacks of a blind NAC (i.e. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011207PMC

Comparative study on the efficacy of non-steroidal, steroid and non-use of anti-inflammatory in the treatment of acute epidemic conjunctivitis.

Acta Cir Bras 2020 7;34(12):e201901206. Epub 2020 Feb 7.

PhD, Full Professor, Coordinator, Postgraduate Program in Surgery, Department of Surgery, UFC, Fortaleza-CE, Brazil. Intellectual and scientific content of the study, critical revision, final approval.

Purpose: To evaluate the effects of prednisolone against sodium diclofenac both with ciprofloxacin compared to artificial tears on the symptoms and signs of acute viral conjunctivitis.

Methods: Study included 37 patients diagnosed with acute conjunctivitis and distributed by three groups: A (1% prednisolone acetate + ciprofloxacin (0.3%); B (Sodium diclofenac (0. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006370PMC

Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.

Acta Cir Bras 2020 7;34(12):e201901205. Epub 2020 Feb 7.

Bachelor, Department of Anesthesiology, People's Hospital of Bishan District, Chongqing 402760, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.

Methods: Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats in each group. The isoflurane+HupA group was intraperitoneally injected with 0. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006372PMC

Effect of short-term ischemia on microcirculation and wound healing of adipocutaneous flaps in the rat.

Acta Cir Bras 2020 10;34(12):e201901203. Epub 2020 Feb 10.

PhD, DSc, Department of Operative Techniques and Surgical Research, Institute of Surgery, Faculty of Medicine, University of Debrecen, Hungary. Conception and design of the study, analysis and interpretation of data, manuscript preparation.

Purpose: Composite flaps used in reconstructive surgery may intra- and postoperatively suffer from hypoperfusion and/or ischemia-reperfusion influencing wound healing. We aimed to follow-up the effect of ischemia on adipocutaneous flaps' wound healing and microcirculation.

Methods: In anesthetized rats groin flaps were formed bilaterally. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011208PMC

Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo.

Acta Cir Bras 2020 7;34(12):e201901202. Epub 2020 Feb 7.

PhD, Professor, Department of Basic Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China. Critical revision, final approval.

Purpose: To explore the potential role and unclear molecular mechanisms of vaccarin in wound healing.

Methods: Rats' skin excision model to study the effects of vaccarin on wound healing in vivo . Hematoxylin and eosin staining was performed to evaluate Histopathologic characteristics. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006371PMC

New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory.

Acta Cir Bras 2020 3;34(12):e201901201. Epub 2020 Feb 3.

PhD, Full Professor, Medical School, UNICHRISTUS, Fortaleza-CE, Brazil. Conception and design of the study, acquisition and interpretation of data, manuscript preparation, critical revision.

Purpose: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam).

Methods: Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Read More

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http://dx.doi.org/10.1590/s0102-865020190120000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6998060PMC

GDF11 ameliorated myocardial ischemia reperfusion injury by antioxidant stress and up-regulating autophagy in STZ-induced type 1 diabetic rats.

Acta Cir Bras 2020 13;34(11):e201901106. Epub 2020 Jan 13.

Full Professor, Department of Anesthesiology, Renmin Hospital of Wuhan University, China. Design and supervised all phases of the study, final approval.

Purpose: To investigate whether GDF11 ameliorates myocardial ischemia reperfusion (MIR) injury in diabetic rats and explore the underlying mechanisms.

Methods: Diabetic and non-diabetic rats subjected to MIR (30 min of coronary artery occlusion followed by 120 min of reperfusion) with/without GDF11 pretreatment. Cardiac function, myocardial infarct size, creatine kinase-MB (CK-MB), lactate dehydrogenase (LDH), superoxide dismutase (SOD) 15-F2tisoprostane, autophagosome, LC3II/I ratio and Belcin-1 level were determined to reflect myocardial injury, oxidative stress and autophagy, respectively. Read More

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http://dx.doi.org/10.1590/s0102-865020190110000006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958563PMC

Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats.

Acta Cir Bras 2020 13;34(11):e201901101. Epub 2020 Jan 13.

PhD, Associate Professor of Pathology, Health Sciences Center, UESPI, Teresina-PI, Brazil. Histopathological examinations, critical revision.

Purpose: To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair.

Methods: Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically. Read More

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http://dx.doi.org/10.1590/s0102-865020190110000001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6958576PMC
March 2020
0.570 Impact Factor

Characterization of the intestinal graft in a swine hypotensive after brain death model.

Acta Cir Bras 2020 10;34(11):e201901107. Epub 2020 Jan 10.

MD, Department of General Surgery, Linyi People's Hospital, Xuzhou Medical University, Linyi, 276000, China. Conception and design of the study.

Purpose: To establish a hypotensive brain death pig model and observe the effects of hypotension on small bowel donors.

Methods: The hypotensive brain death model was produced using the modified intracranial water sac inflation method in ten domestic crossbred pigs. Effects of hypotensive brain death on small bowel tissue morphology were evaluated through changes in intestinal tissue pathology, tight junction protein of the intestinal mucosa and plasma intestinal fatty acid-binding protein (i-FABP) levels. Read More

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http://dx.doi.org/10.1590/s0102-865020190110000007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956644PMC

Assessment of remnant liver function and volume after selective ligation of portal vein and hepatic artery in a rat model.

Acta Cir Bras 2020 10;34(11):e201901103. Epub 2020 Jan 10.

PhD, Assistant Professor, Department of Surgery, Faculty of Medicine, UFRJ, Rio de Janeiro-RJ, Brazil. Interpretation and analysis of data, critical revision.

Purpose: To evaluate liver regeneration after selective ligation of portal vein and hepatic artery by 3D Computed Tomography in an experimental model.

Methods: Sixteen Wistar rats were randomized into four equal groups: Group I- control (sham), Group II- isolated selective ligation of the hepatic artery, Group III- isolated selective ligation of the portal vein and Group IV- combined ligation of portal vein and hepatic artery. Before procedure and five days after a 3D CT Scan was performed to analyze the hypertrophy, weight and function of the remnant liver. Read More

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http://dx.doi.org/10.1590/s0102-865020190110000003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956645PMC

Dexmedetomidine attenuates P2X4 and NLRP3 expression in the spine of rats with diabetic neuropathic pain.

Acta Cir Bras 2019 20;34(11):e201901105. Epub 2019 Dec 20.

PhD, Full Professor, Department of Anesthesia, Renmin Hospital of Wuhan University, Wuhan, China. Design and supervised all phases of the study, critical revision.

Purpose: To evaluate the effects of Dexmedetomidine (Dex) on spinal pathology and inflammatory factor in a rat model of Diabetic neuropathic pain (DNP).

Methods: The rats were divided into 3 groups (eight in each group): normal group (N group), diabetic neuropathic pain model group (DNP group), and DNP model with dexmedetomidine (Dex group). The rat model of diabetes was established with intraperitoneal streptozotocin (STZ) injections. Read More

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http://dx.doi.org/10.1590/s0102-865020190110000005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6917476PMC
February 2020