2,087 results match your criteria Acta Cirurgica Brasileira[Journal]


Kukoamine A activates Akt/GSK-3β signaling pathway to inhibit oxidative stress and relieve myocardial ischemia-reperfusion injury.

Acta Cir Bras 2022 22;37(4):e370407. Epub 2022 Jul 22.

PhD. The First Hospital of Lanzhou University - Department of Ultrasound - Gansu Province, China.

Purpose: Myocardial ischemia/reperfusion (MI/R) injury refers to a pathological condition of treatment of myocardial infarction. Oxidative stress and inflammation are believed to be important mechanisms mediating MI/R injury. Kukoamine A (KuA), a sperm, is the main bioactive component extracted from the bark of goji berries. Read More

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Antifibrotic preventive effect of polyethylene glycol (PEG) 3350 in methotrexateinduced hepatoxicity model.

Acta Cir Bras 2022 22;37(5):e370507. Epub 2022 Jul 22.

Associate professor. Demiroğlu Bilim University - Faculty of Medicine - Department of Physiology - Istanbul, Turkey.

Purpose: Liver damage caused by drugs and other chemicals accounts for about 5% of all cases. Methotrexate (MTX), a folic acid analogue, is a first-line synthetic antimetabolite agent routinely used in the treatment of rheumatoid arthritis and other autoimmune and chronic inflammatory diseases. Polyethylene glycol (PEG) has antioxidant activity. Read More

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Histone deacetylase inhibitor givinostat has ameliorative effect in the colitis model.

Acta Cir Bras 2022 22;37(5):e370503. Epub 2022 Jul 22.

MD. Demiroğlu Bilim University - Faculty of Medicine - Department of Physiology - İstanbul, Turkey.

Purpose: To investigate the effect of givinostat treatment in acetic acid-induced ulcerative colitis model in rats.

Methods: Thirty male Wistar albino rats were used. Rats were randomly divided into three equal groups, and colitis was induced on 20 rats by rectal administration of %4 solutions of acetic acid. Read More

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Effects of different gastrointestinal reconstruction techniques on nutrition, anemia, and quality of life in laparoscopic distal gastrectomy for gastric cancer.

Acta Cir Bras 2022 15;37(4):e370408. Epub 2022 Jul 15.

PhD. Chengdu Second People's Hospital - Department of Digestive Medicine - Chengdu, China.

Purpose: To explore the effect of different gastrointestinal reconstruction techniques on laparoscopic distal gastrectomy of gastric cancer on the nutritional and anemia status, and quality of life (QoL) of patients.

Methods: Eligible patients were randomly divided into three groups (n=36/group): Billroth I anastomosis group, Billroth II combined with Braun anastomosis group, and Roux-en-Y anastomosis group. Related indicators were compared and analyzed. Read More

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The effects of valproic acid on skin healing: experimental study in rats.

Acta Cir Bras 2022 15;37(4):e370403. Epub 2022 Jul 15.

Physician. Universidade Federal do Paraná - Veterinary Hospital - Curitiba (PR), Brazil.

Purpose: To recognize the effects of valproic acid (VPA), an epigenetic drug, on the skin healing process.

Methods: Sixty male Wistar rats were divided into two groups: the experiment treated with VPA (100 mg/kg/day); and the control, with 0.9% sodium chloride by gavage. Read More

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Hydrogel-based dressings in the treatment of partial thickness experimentally induced burn wounds in rats.

Acta Cir Bras 2022 1;37(4):e370401. Epub 2022 Jul 1.

PhD. Universidade Federal de Goiás - Tropical Pathology and Public Health Institute - Biosciences Department - Goiânia (GO), Brazil.

Purpose: To compare four commercially available hydrogel formulations in the healing of partial thickness burns experimentally induced in rats.

Methods: Wistar rats were used, and after the burn wound induction they were divided into the following treatment groups: G1) NaCl 0.9%; G2) 1% silver sulfadiazine; G3) Debrigel™; G4) Safgel™; G5) Dersani™; G6) Solosite™. Read More

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Effect of penehyclidine hydrochloride on inflammatory response and oxidative stress in rats with cardiopulmonary bypass related-lung injury.

Acta Cir Bras 2022 27;37(4):e370406. Epub 2022 Jun 27.

MD. Huazhong University of Science and Technology - Tongji Medical College - Tongji Hospital - Department of Anesthesiology - Wuhan, China.

Purpose: To investigate the protective effect of penehyclidine hydrochloride (PHC) on cardiopulmonary bypass (CPB)-related lung injury in rats.

Methods: Thirty-six rats were divided into control, CPB and PHC groups. The CPB model was established in CPB and PHC groups. Read More

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Evaluation of the degradation of two bioabsorbable interference screws: an in-vivo study in sheep.

Acta Cir Bras 2022 27;37(4):e370405. Epub 2022 Jun 27.

PhD. Universidade de Marília - Veterinary Medicine School - Marília (SP), Brazil.

Purpose: To evaluate in-vivo degradation of two bioabsorbable interference screws.

Methods: Twenty-two crossbred Santa Inês ewes were used. A poly-DL-lactide (PDLLA) screw (70%/30%) was inserted in the right pelvic limb, and a PDLLA screw (70%) + β-tri-calcium phosphate (β-TCP) (30%) in the left pelvic limb. Read More

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Histopathological, immunohistochemical and biochemical alterations in liver tissue after fungicide-mancozeb exposures in Wistar albino rats.

Acta Cir Bras 2022 27;37(4):e370404. Epub 2022 Jun 27.

PhD. Dicle University - Faculty of Medicine - Department of Histology and Embryology - Diyarbakir, Turkey.

Purpose: To evaluate the histopathological, immunohistochemical, and biochemical effects of liver changes after mancozeb administration.

Methods: Rats were divided into groups-the control group (n=7) and the mancozeb group (n=7)-, given 500 mg/kg mancozeb dissolved in corn oil daily for four weeks by an orogastric tube. Caspase-3 and tumor necrosis factor-alpha (TNF-α) primary antibodies were used for immunohistochemical analysis. Read More

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Effect of electrophysical resources on healing of neurotendinous injury in an experimental model of type I diabetes and kidney disease.

Acta Cir Bras 2022 27;37(4):e370402. Epub 2022 Jun 27.

PhD. Universidade Federal do Mato Grosso do Sul - Postgraduate Program in Health and Development - Campo Grande (MS), Brazil.

Purpose: To evaluate and describe the effect of electrophysical resources laser therapy (LLLT), intravascular laser blood irradiation (ILIB), and cryotherapy on the healing process of neurotendinous injury, as well as possible systemic changes, in the experimental model of type 1 diabetes associated with kidney injury.

Methods: The animals were randomized into four groups: G1) healthy control with untreated injury; G2) healthy control with injury and treatment; G3) disease control with untreated lesion; G4) disease with injury and treatment. Furthermore, the treated groups were divided into three, according to the type of treatment. Read More

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Assessing ultrasonographic optic nerve sheath diameter in animal model with anesthesia regimens.

Acta Cir Bras 2022 15;37(3):e370308. Epub 2022 Jun 15.

MD. PhD. Universidade de São Paulo - School of Medicine - Hospital das Clínicas - Division of Neurological Surgery - São Paulo (SP), Brazil.

Purpose: To determine the normal optical nerve sheath (ONS) diameter ultrasonography (ONSUS) and evaluate the possible effects of drugs on ONS diameter during anesthetic induction in healthy pigs.

Methods: Healthy piglets were divided into three groups: a control group, that received xylazine and ketamine (X/K); other that received xylazine, ketamine and propofol (X/K/P); and a third group that received xylazine, ketamine, and thiopental (X/K/T). The sheath diameter was assessed by ultrasonography calculating the average of three measurements of each eye from the left and right sides. Read More

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Protective effect of hydroxysafflor yellow A on cyclosporin A-induced renal oxidative stress in vitro and in vivo.

Authors:
Jiyuan Wang Yu Chen

Acta Cir Bras 2022 15;37(3):e370305. Epub 2022 Jun 15.

MSc. Second Military Medical University - Shanghai ChangZheng Hospital - Department of Organ Transplantation - Shanghai, China.

Purpose: To explore the mechanism and investigate the protective effect of hydroxysafflor yellow A (HSYA) on renal oxidative stress, which cyclosporine A (CsA) induces.

Methods: HK-2 cells were treated with CsA to get CsA-induced oxidative stress. The effects on oxidative stress and apoptosis of HK-2 cells were detected. Read More

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Anatomical description of the ventral and dorsal cervical rootlets in rats: A microsurgical study.

Acta Cir Bras 2022 1;37(3):e370307. Epub 2022 Jun 1.

PhD. Associate Professor. Universidade do Estado do Pará - School of Medicine - Department of Experimental Surgery - Belém (PA), Brazil.

Purpose: To describe the anatomical aspects of the cervical rootlets and to quantify the number of rootlets that compose C1 to T1.

Methods: Twenty male rats were used in this study. The dorsal rootlets from C1 to T1 were analyzed. Read More

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Biofilm model on mice skin wounds.

Acta Cir Bras 2022 1;37(3):e370306. Epub 2022 Jun 1.

PhD. Universidade Federal de Minas Gerais - Institute of Biological Sciences - Department of Physiology and Biophysics - Belo Horizonte (MG), Brazil.

Purpose: To evaluate a biofilm model of Pseudomonas aeruginosa in excisional cutaneous wound in mice.

Methods: Preclinical, translational study conducted with 64 C57BL/6 mice randomly assigned to control and intervention groups. Evaluation was on days D0, D3, D5, D7 and D10 of wound making. Read More

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Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats.

Acta Cir Bras 2022 1;37(3):e370304. Epub 2022 Jun 1.

MD. Peking Union Medical College and Chinese Academy of Medical Sciences - Institute of Medicinal Plant Development - Beijing, China.

Purpose: To investigate the protective effects of Shenkang injection (SKI) on adenine-induced chronic renal failure (CRF) in rat.

Methods: Sprague Dawley rats were randomly divided into five groups: control, model, and SKI groups (5, 10, 20 mL/kg). Rats in model and SKI groups were treated with adenine i. Read More

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Potential influences of expression levels of MFGE8 and HMGB1 on the intestinal mucosal barrier function and inflammatory response after blunt abdominal injury in rats.

Acta Cir Bras 2022 1;37(3):e370303. Epub 2022 Jun 1.

MD. The First Affiliated Hospital of Wenzhou Medical University - Department of Trauma Surgery (Emergency Surgery) - Wenzhou, China.

Purpose: To explore the influence of milk fat globule-EGF factor 8 protein (MFGE8) on blunt abdominal injury in Sprague Dawley (SD) rats through the RhoA/ROCK signaling pathway.

Methods: The blunt abdominal injury model was generated in SD rats. A total of 44 rats was randomly assigned into three groups. Read More

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Development and characterization of poultry collagen-based hybrid hydrogels for bone regeneration.

Acta Cir Bras 2022 13;37(3):e370302. Epub 2022 May 13.

PhD. Universidade Federal do Ceará - Postgraduate Program in Biotechnology - Sobral (CE), Brazil.

Purpose: Poultry by-products can contribute as an innovative natural source for the development of composites based on polymers and minerals aiming at bone regeneration. The objective of this study was the physicochemical and biological characterization of collagen-based hydrogels crosslinked with ultraviolet (UV)-riboflavin.

Methods: Pure hydrogels of 100% collagen (G1) or hybrid hydrogels, 90% collagen:10% apatite (G2), 90% collagen:10% nanokeratin (G3), and 90% collagen:5% apatite:5% nanokeratin (G4) were characterized by scanning electron microscope, Fourier-transform infrared spectroscopy, differential scanning calorimetry, swelling degree and quali-quantitative histological analysis. Read More

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Ulinastatin alleviates early brain injury after intracerebral hemorrhage by inhibiting necroptosis and neuroinflammation via MAPK/NF-κB signaling pathway.

Acta Cir Bras 2022 13;37(3):e370301. Epub 2022 May 13.

MD. Anhui Medical University - Wuxi Clinical College - 904th Hospital of Joint Logistic Support Force of PLA - Department of Neurology - Wuxi, China.

Purpose: Spontaneous intracerebral hemorrhage (ICH) is a major public health problem with a huge economic burden worldwide. Ulinastatin (UTI), a serine protease inhibitor, has been reported to be anti-inflammatory, immune regulation, and organ protection by reducing reactive oxygen species production, and inflammation. Necroptosis is a programmed cell death mechanism that plays a vital role in neuronal cell death after ICH. Read More

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Protective effects of melatonin in cisplatin-induced cardiac toxicity: possible role of BDNF-TNF-α signaling pathway.

Acta Cir Bras 2022 2;37(2):e370208. Epub 2022 May 2.

MM. Department of Cardiology - Shandong Second Provincial General Hospital (Shandong ENT Hospital) - Jinan, China.

Purpose: The present study explored the role of melatonin in cisplatin-induced cardiac injury along with the possible role of brain-derived neurotrophic factor (BDNF) in melatonin-mediated effects.

Methods: Wistar rats were administered cisplatin (10 mg/kg), and cardiac injury was assessed by measuring the levels of cardiac troponin (cTnT) and lactate dehydrogenase (LDH-1).The extent of apoptosis was measured by measuring caspase-3 (pro-apoptotic) and Bcl-2 (anti-apoptotic) in hearts. Read More

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Analysis of high-intensity interval training on bone mineral density in an experimental model of type 2 diabetes.

Acta Cir Bras 2022 2;37(2):e370207. Epub 2022 May 2.

Nutritionist. Universidade Federal do Mato Grosso do Sul - Faculty of Pharmaceutical Sciences - Research and Production Laboratory- Campo Grande (MS), Brazil.

Purpose: To analyze the effect of high-intensity interval training (HIIT) on bone mineral density (BMD) in a model of type 2 diabetes mellitus.

Methods: Thirty-two male, adult, 12-week-old rats (Rattus norvegicus), of the Wistar lineage, were used. The animals induced to the experimental model received a high fat diet for 10 days and, after that period, intraperitoneal injection of streptozotocin (40 mg·kg-1), dissolved in 20 mmol·L-1 sodium citrate solution (pH = 4. Read More

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Anatomorphometry of the brachial plexus under high-definition system: an experimental study in rats.

Acta Cir Bras 2022 2;37(2):e370206. Epub 2022 May 2.

MD. Universidade do Estado do Pará -School of Medicine - Department of Experimental Hand Surgery - Laboratory of Experimental Surgery - Belém (PA), Brazil.

Purpose: To study the anatomorphometry of the plexus brachialis (PB) of rats under a high-definition video system.

Methods: Ten male Wistar rats discarded from other research that did not interfere in the morphology of the animal, respecting the principle of reduction, were used. All animals were submitted to the same protocol. Read More

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Immunomodulatory effects of Blaps rynchopetera extract.

Acta Cir Bras 2022 2;37(2):e370205. Epub 2022 May 2.

PhD. Professor. Dali University - College of Pharmacy - Dali, China, and Yunnan University - Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province - Kunming, China.

Purpose: To explore the potential immunomodulatory effects of total extract and different polar parts from Blaps rynchopetera Fairmaire.

Methods: Phagocytic activity was evaluated by neutral red assay, and the effect of the immune function was investigated by normal and immunocompromised mice models.

Results: In vitro, total extract, as well as chloroform, ethyl acetate, n-butanol and water fractions could individually enhance the phagocytic ability of mouse peritoneal macrophages; in addition, chloroform and ethyl acetate fractions had an increasing tendency when combined stimulation with lipopolysaccharide (LPS). Read More

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Protective effect of polysaccharides isolated from the seeds of Cuscuta chinensis Lam. on 5-fluorouracil-induced intestinal mucositis in mice.

Acta Cir Bras 2022 2;37(2):e370204. Epub 2022 May 2.

MD. Syndrome Laboratory of Integrated of Chinese and Western Medicine - School of Chinese Medicine - Southern Medical University - Guangzhou, China.

Purpose: To evaluate the protective effect of Cuscuta chinensis Lam. polysaccharides (PCCL) on 5-fluorouracil-(5-FU)-induced intestinal mucositis (IM) in mice.

Methods: PCCL was orally administered at a dose of 20 mg·kg-1 for 7 days and its protective effect on 5-FU-induced IM (5-FU, 50 mg·kg-1 for 5 days) was evaluated by monitoring changes in body weight, degree of diarrhea, levels of tissue inflammatory factors (tumor necrosis factor α, interleukin 6, and interleukin 1β levels), apoptosis rates, and the expression levels of caspase-3, Bax and Bcl-2. Read More

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Mechanism of dexmedetomidine preconditioning on spinal cord analgesia in rats with functional chronic visceral pain.

Acta Cir Bras 2022 2;37(2):e370203. Epub 2022 May 2.

MD. Department of Anesthesiology - General Hospital of Southern Theatre Command - Guangzhou, China.

Purpose: To analyze the effect and mechanism of dexmedetomidine (DEX) analgesia pretreatment on functional chronic visceral pain in rats.

Methods: Rats were divided into six groups: W1, W2, W3, W4, W5, and W6. The behavioral changes and electrophysiological indexes of rats in each group before and after DEX treatment were detected. Read More

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Ulinastatin alleviates early brain injury after traumatic brain injury by inhibiting oxidative stress and apoptosis.

Acta Cir Bras 2022 20;37(1):e370108. Epub 2022 Apr 20.

PhD. Department of Neurosurgery - 904th Hospital of Joint Logistic Support Force of PLA - Wuxi Clinical College of Anhui Medical University - Wuxi, China.

Purpose: Traumatic brain injury (TBI) remains a major public health problem and cause of death. Ulinastatin (UTI), a serine protease inhibitor, has been reported to have an anti-inflammatory effect and play a role in immunoregulation and organ protection by reducing reactive oxygen species (ROS) production, oxidative stress and inflammation. However, the neuroprotective of UTI in TBI has not been confirmed. Read More

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Evaluation of psychological symptoms in patients before and after simultaneous pancreas-kidney transplantation: a single-center cross-sectional study.

Acta Cir Bras 2022 22;37(2):e370202. Epub 2022 Apr 22.

Full Professor. Department of Nephrology - Universidade Federal de São Paulo - Sao Paulo (SP), Brazil.

Purpose: Simultaneous pancreas-kidney transplantation (SPKT) brings several benefits for insulin-dependent type-1 diabetic patients associated with end-stage renal disease (ESRD). However, data on psychological outcomes for the waiting list and the transplanted patients are still lacking.

Methods: Using the psychological Beck inventories of anxiety (BAI) and depression (BDI), 39 patients on the waiting list were compared to 88 post-transplanted patients who had undergone SPKT. Read More

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TGF-β1 and CD68 immunoexpression in capsules formed by textured implants with and without mesh coverage: a study on female rats.

Acta Cir Bras 2022 22;37(2):e370201. Epub 2022 Apr 22.

PhD in Plastic Surgery. Universidade Estadual de Ponta Grossa - Ponta Grossa (PR), Brazil.

Purpose: To evaluate fibrosis formation and number of macrophages in capsules formed around textured implants without and with mesh coverage.

Methods: Fibrosis was analyzed through transforming growth factor-beta 1 (TGF-β1) immunomarker expression and the number of macrophages through CD68 percentage of cells in magnified field. Sixty female Wistar rats were distributed into two groups of 30 rats (unmeshed and meshed). Read More

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Could outcomes of intracranial aneurysms be better predict using serum creatinine and glomerular filtration rate?

Acta Cir Bras 2022 8;37(1):e370107. Epub 2022 Apr 8.

PhD. Universidade de São Paulo - Department of Neurosurgery - São Paulo (SP), Brazil.

Purpose: To analyze the role of serum creatinine levels as a biomarker of intracranial aneurysm outcomes.

Methods: This is a prospective analysis of outcomes of patients with intracranial aneurysm. One hundred forty-seven patients with serum creatinine at admission and 6 months follow up were included. Read More

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Experimental model for controlled endoscopic subepithelial vocal fold injury in rats.

Acta Cir Bras 2022 8;37(1):e370106. Epub 2022 Apr 8.

Professor. University of Medicine and Pharmacy "Iuliu Hatieganu" - Department of Otolaryngology - Cluj-Napoca, Romania.

Purpose: To present a detailed, reproducible, cost-efficient surgical model for controlled subepithelial endoscopic vocal fold injury in the rat model.

Methods: Six male Sprague Dawley rats were enrolled in the experiment. The left vocal folds were used to carry out the injury model, and the right vocal fold served as control. Read More

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