1,790 results match your criteria Acta Cirurgica Brasileira[Journal]


The role of high sensitive C-reactive protein and histopathological evaluation in chronic gastritis patients with or without Helicobacter pylori infection.

Acta Cir Bras 2019 Mar 21;34(3):e201900310. Epub 2019 Mar 21.

Assistant Professor, Balikesir Universty, Faculty of Medicine, Department of Pathology, Balikesir, Turkey. Scientific, intellectual, conception and design of the study; acquisition of data; technical procedures; histopathological examinations; manuscript preparation and writing; critical revision.

Purpose: To evaluate serum levels of high-sensitivity C-reactive protein (hs-CRP) in chronic gastritis patients to predict Helicobacter pylori (HP) infection, inflammatory activity, and precancerous lesions.

Methods: A total of 811 patients with upper gastrointestinal symptoms and histopathological diagnosis of chronic gastritis were enrolled in the study. On endoscopy, five gastric biopsies were taken according to Modified Sydney protocol, which were stained with hematoxylin & eosin and Giemsa. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000010DOI Listing
March 2019
1 Read

Videothermometry to evaluate metabolic activity in real time during pneumectomy in rats.

Acta Cir Bras 2019 Mar 21;34(3):e201900302. Epub 2019 Mar 21.

PhD, Associate Professor, UEA, UENF, Rio de Janeiro-RJ, Brazil. Scientific and intellectual content of the study, critical revision, final approval.

Purpose: To evaluate, in rats, the open field videothermometry in real time while performing left pneumonectomy for early diagnosis of cardiopulmonary changes.

Methods: Twelve non-specific pathogen-free Wistar rats were randomly allocated into two groups; pneumectomy group (GP) and sham surgery group (GS). Mean arterial pressure, videothermometry in real time, of the right lung, and histopathological analysis of the remaining lung were evaluated in all animals. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000002DOI Listing

Unexpectedly prolonged fasting and its consequences on elderly patients undergoing spinal anesthetics. A prospective observational study1.

Acta Cir Bras 2019 Mar 18;34(3):e201900309. Epub 2019 Mar 18.

MD, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Department of Anesthesiology and Reanimation, Izmir, Turkey. Conception and design of the study, analysis and interpretation of data, technical procedures, manuscript preparation, final approval.

Purpose: To measure the preoperative fasting durations with respect to time of the day and its effect on vital parameters and electrocardiogram in elderly patients undergoing surgery under spinal anesthesia.

Methods: This study investigated 211 patients older than 60 years undergoing elective surgery under spinal anesthesia. Patients scheduled for surgery in morning hours (AM) and afternoon hours (PM) were compared. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000009DOI Listing
March 2019
4 Reads

Evaluation tool for a gastroenterostomy simulated training1.

Acta Cir Bras 2019 Mar 18;34(3):e201900308. Epub 2019 Mar 18.

MD, Holy House of Mercy of Fortaleza, Professional Master's Degree Program in Minimally Invasive Technology and Simulation in Health, UNICHRISTUS, Fortaleza-CE, Brazil. Conception and design of the study, interpretation and analysis of data, critical revision, final approval.

Purpose: To create a checklist to evaluate the performance and systematize the gastroenterostomy simulated training.

Methods: Experimental longitudinal study of a quantitative character. The sample consisted of twelve general surgery residents. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000008DOI Listing
March 2019
1 Read

Ointment of Ximenes americana promotes acceleration of wound healing in rats1.

Acta Cir Bras 2019 Mar 18;34(3):e201900307. Epub 2019 Mar 18.

Full Professor, Department of Morphology and Animal Physiology, UFRPE, Recife-PE, Brazil. Conception and design of the study, manuscript preparation, critical revision.

Purpose: To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats.

Methods: Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hydroalcoholic extract of X. americana applied on 10%, Lanette base and Control, untreated wounds. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000007DOI Listing
March 2019
12 Reads

The effect of graft application and allopurinol treatment on calvarial bone defect in rats1.

Acta Cir Bras 2019 Mar 18;34(3):e201900306. Epub 2019 Mar 18.

PhD, Professor, Department of Anatomy, Faculty of Medicine, Dicle University, Diyarbakır, Turkey. Technical procedures, histopathological examinations, manuscript preparation and writing, final approval.

Purpose: To investigate the effects of allopurinol administration on osteoinductive reaction and bone development with graft material.

Methods: Thirty-six Wistar albino rats were divided into 3 groups. In the control group, calvarial bone defect was only created without any treatment. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000006DOI Listing
March 2019
1 Read

Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats1.

Acta Cir Bras 2019 Mar 18;34(3):e201900305. Epub 2019 Mar 18.

Professor, Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University, Erzincan, Turkey. Manuscript writing, critical revision, final approval.

Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).

Methods: The anticancer activity of EtOAc extract of U. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000005DOI Listing
March 2019
9 Reads

Does the type of electrode affect the electromyoneurographic parameters in rats?1.

Acta Cir Bras 2019 Mar 18;34(3):e201900304. Epub 2019 Mar 18.

PhD, Associate Professor, Department of Experimental Surgery, School of Medicine, UEPA, Belem-PA, Brazil. Scientific content of the study, critical revision.

Purpose: To evaluate if the type of electrode (needle vs. surface) affects the electromyoneurography parameters in rats.

Methods: Twenty male rats were anesthetized, then compound muscle action potential were recorded using a Neuropack S1 MEB- 9400©. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000004DOI Listing
March 2019
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New determinants for casual peripheral mechanism of neurogenic lung edema in subarachnoid hemorrhage due to ischemic degeneration of vagal nerve, kidney and lung circuitry. Experimental study1.

Acta Cir Bras 2019 Mar 18;34(3):e201900303. Epub 2019 Mar 18.

MD, Department of Pathology, Medical Faculty, Ataturk University, Erzurum, Turkey. Histopathological examinations.

Purpose: To evaluate whether there is a relationship between renal artery vasospasm related low glomerular density or degeneration and neurogenic lung edema (NLE) following subarachnoid hemorrhage.

Methods: This study was conducted on 26 rabbits. A control group was formed of five animals, a SHAM group of 5 to which saline and a study group (n=16) injected with homologous blood into the sylvian cisterna. Read More

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http://dx.doi.org/10.1590/s0102-865020190030000003DOI Listing
March 2019
1 Read

Undernutrition impairs the quality of growth plate and trabecular and cortical bones in growing rats1.

Acta Cir Bras 2019 Mar 18;34(3):e201900301. Epub 2019 Mar 18.

Full Professor, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, School of Medicine, USP, Ribeirao Preto-SP, Brazil. Design, intellectual and scientific content of the study; critical revision; final approval the manuscript.

Purpose: To investigate the effects of dietary restriction on the growth plate and long bone tissue in growing rats.

Methods: Sixty male Wistar rats were randomly assigned to two groups: Control (Con) and Diet-restricted (Res). After weaning, the Res rats were offered 50% of the chow ingested by the control (ad libitum food intake). Read More

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http://dx.doi.org/10.1590/s0102-865020190030000001DOI Listing
March 2019
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Effect of low power laser in biomodulation of cultured osteoblastic cells of Wistar rats1.

Acta Cir Bras 2019 Feb 28;34(2):e201900210. Epub 2019 Feb 28.

Associate Professor, Department of Surgery, Medical School, UNIFESP, Sao Paulo-SP, Brazil. Conception, design, intellectual and scientific content of the study; critical revision.

Purpose: To analyze aspects of the biomodulating effect of light in biological tissues, bone cells from surgical explants of the femur of rats were irradiated with low intensity laser.

Methods: Bone cells were cultured and irradiated with LASER light (GaAlAs). Growth, cell viability, mineralized matrix formation, total protein dosage, immunostimulatory properties, cytochemical analysis, gene expression of bone proteins were examined using live cell imaging and cell counting by colorimetric assay. Read More

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http://dx.doi.org/10.1590/s0102-8650201900210DOI Listing
February 2019
1 Read

Milk fat globule-epidermal growth factor 8 (MFG-E8) attenuates sepsis-induced acute kidney injury by inhibiting NF-κB signaling pathway1.

Acta Cir Bras 2019 Feb 28;34(2):e201900209. Epub 2019 Feb 28.

Master, Chairman and Head, Department of Critical Care Medicine, Shengjing Hospital, China Medical University, Shenyang, China. Conception and design of the study, critical revision.

Purpose: To explore the effect of milk fat globule-epidermal growth factor 8 (MFG-E8) on sepsis-induced acute kidney injury (SAKI).

Methods: Male C57BL/6 mice were randomized to control, sham, CLP, CLP+PBS, and CLP+rmMFG-E8 groups. SAKI was induced by cecal ligation and puncture (CLP). Read More

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http://dx.doi.org/10.1590/s0102-8650201900209DOI Listing
February 2019
1 Read
0.570 Impact Factor

Effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury1.

Authors:
Yan Li Fanjun Meng

Acta Cir Bras 2019 Feb 28;34(2):e201900208. Epub 2019 Feb 28.

MD, Department of Anesthesiology, Jinan City Central Hospital Affiliated to Shandong University, P.R. China. Design of the study, manuscript preparation, critical revision, final approval.

Purpose: To investigate the effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury (CIRI).

Methods: One hundred SD rats were randomly divided into sham-operated, model, and 5, 10 and 20 mg/kg icariside II groups, 20 rats in each group. The middle cerebral artery occlusion model (ischemia for 2 h followed by reperfusion for 24 h) was established in the later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-8650201900208DOI Listing
February 2019
0.570 Impact Factor

Gum arabic and red propolis protecteting colorectal preneoplastic lesions in a rat model of azoxymethane1.

Acta Cir Bras 2019 Feb 28;34(2):e201900207. Epub 2019 Feb 28.

PhD, Associate Professor, Postgraduate Program in Pathology and Medical-Surgical Sciences, School of Medicine, UFC, Fortaleza-CE, Brazil. Design of the study, critical revision, final approval.

Purpose: To evaluate red propolis, gum arabic and L-lysine activity on colorectal preneoplastic lesions induced by azoxymethane (AOM).

Methods: The study featured 4 control groups (I-IV) and 4 experimental groups (V-VIII), totaling 48 rats. Once a week for 2 weeks, animals on control groups received saline, while animals in experimental groups received azoxymethane (15 mg/kg i. Read More

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http://dx.doi.org/10.1590/s0102-8650201900207DOI Listing
February 2019
6 Reads
0.570 Impact Factor

Transabdominal preperitoneal (TAPP) versus open Lichtenstein hernia repair. Comparison of the systemic inflammatory response and the postoperative pain1.

Acta Cir Bras 2019 Feb 28;34(2):e201900206. Epub 2019 Feb 28.

PhD, Associate Professor, Department of Surgery and Anatomy, Clinical Hospital, Faculty of Medicine, Universidade de São Paulo (USP), Ribeirao Preto-SP, Brazil. Conception and design of the study, analysis and interpretation of data, manuscript preparation and writing, critical revision, final approval.

Purpose: To compare open Lichtenstein repair and laparoscopic transabdominal preperitoneal (TAPP) repair to treat primary unilateral hernia, regarding systemic inflammatory response, postoperative pain, and complications.

Methods: A non-randomized prospective cohort study, with the preoperative and postoperative (24 hours) collection of blood samples for C reactive protein (CRP), interleukin 6 (IL-6), leukocyte and neutrophil analysis. Visual Analog Scale (VAS) was used to quantify the level of pain, and the operative time was correlated with the inflammatory response. Read More

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http://dx.doi.org/10.1590/s0102-8650201900206DOI Listing
February 2019
6 Reads

Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice1.

Acta Cir Bras 2019 Feb 28;34(2):e201900205. Epub 2019 Feb 28.

PhD, Urologist, Department of Surgery, UFC, Fortaleza-CE, Brazil. Conception and design of the study, interpretation and analysis of data, critical revision, final approval.

Purpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms.

Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. Read More

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http://dx.doi.org/10.1590/s0102-8650201900205DOI Listing
February 2019

Salvianolic acid A alleviates the renal damage in rats with chronic renal failure1.

Acta Cir Bras 2019 Feb 28;34(2):e201900204. Epub 2019 Feb 28.

Master, Department of Urology, Affiliated Hospital, Beihua University, China. Design of the study, critical revision, final approval.

Purpose: To investigate the protective effects of salvianolic acid A (SAA) on renal damage in rats with chronic renal failure (CRF).

Methods: The five-sixth nephrectomy model of CRF was successfully established in group CRF (10 rats) and group CRF+SAA (10 rats). Ten rats were selected as sham-operated group (group S), in which only the capsules of both kidneys were removed. Read More

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http://dx.doi.org/10.1590/s0102-8650201900204DOI Listing
February 2019
5 Reads

Influence of the geometry of nanostructured hydroxyapatite and alginate composites in the initial phase of bone repair1.

Acta Cir Bras 2019 Feb 28;34(2):e201900203. Epub 2019 Feb 28.

PhD, Associate Professor, Health Sciences Institute, UFBA, Salvador-BA, Brazil. Conception of the study, critical revision.

Purpose: To analyze, histomorphologically, the influence of the geometry of nanostructured hydroxyapatite and alginate (HAn/Alg) composites in the initial phase of the bone repair.

Methods: Fifteen rats were distributed to three groups: MiHA - bone defect filled with HAn/Alg microspheres; GrHA - bone defect filled with HAn/Alg granules; and DV - empty bone defect; evaluated after 15 days postoperatively. The experimental surgical model was the critical bone defect, ≅8. Read More

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http://dx.doi.org/10.1590/s0102-8650201900203DOI Listing
February 2019

Hyaluronic acid in tobacco-exposed rats. Inflammatory reaction, and duration of effect1.

Acta Cir Bras 2019 Feb 28;34(2):e201900202. Epub 2019 Feb 28.

PhD, Division of Plastic Surgery, Hospital das Clínicas, Laboratory of Microsurgery and Plastic Surgery (LIM-04), Medical School, USP, Sao Paulo-SP, Brazil. Intellectual and scientific content of the study, interpretation of data, critical revision.

Purpose: To evaluate the hyaluronic acid (HA) inflammatory reaction, fibroblasts, fibrosis and duration of effect in the dorsal region of tobacco-exposed rats.

Methods: Ten Wistar rats were divided into two groups: tobacco-exposed-group (TEG;n=5) and air-control-group (CG;n=5). The TEG animals were tobacco-exposed twice a day, 30-minutes/session, during 60 days. Read More

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http://dx.doi.org/10.1590/s0102-8650201900202DOI Listing
February 2019

Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats1.

Acta Cir Bras 2019 Feb 28;34(2):e201900201. Epub 2019 Feb 28.

MD, Department of Ophthalmology, Yantai Yuhuangding Hospital, P.R. China. Conception and design of the study, critical revision, final approval.

Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats.

Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats. Ginsenoside Rb1 (20, 40 mg/kg) was injected (i. Read More

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http://dx.doi.org/10.1590/s0102-8650201900201DOI Listing
February 2019

The role of laparoscopy in the propaedeutics of gynecological diagnosis1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000010. Epub 2019 Feb 14.

Associate Professor III, Department of Gynecology and Obstetrics, Botucatu Medical School, UNESP, Botucatu-SP, Brazil. Conception and design of the study, manuscript preparation.

Purpose: To evaluate agreement between pre- and post-laparoscopy gynecological diagnosis in order to demonstrate the rationality of this minimally invasive technique use in gynecological propaedeutics.

Methods: Retrospective chart review study conducted between March 2010 and October 2016 based on a convenience sample. 315 patients undergoing surgical laparoscopy at the Center of Gynecologic Endoscopy and Family Planning of Botucatu Medical School/UNESP. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000010DOI Listing
February 2019
1 Read

Ursodeoxycholic acid in the prevention of gallstones in patients subjected to Roux-en-Y gastric bypass1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000009. Epub 2019 Feb 14.

PhD, Full Professor, Department of Farmacology, UFC, Fortaleza-CE, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the contribution of ursodeoxycholic acid (UDCA) in the first 12 months after Roux-en-Y gastric bypass in the prevention of gallstone formation.

Methods: A community-based clinical trial was conducted. A total of 137 patients were included in the study; 69 were treated with UDCA, starting 30 days after the surgery, at a dose of 150 mg twice daily (300 mg/day) over a period of 5 consecutive months (GROUP A), and 68 were control patients (GROUP B). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000009DOI Listing
February 2019

Patents on hospital medical and dental equipment (EMHO). Question and answer tool.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000008. Epub 2019 Feb 14.

PhD, Postgraduate Program in Technology and Management of Tissue Regeneration, Medical School, UNIFESP, Sao Paulo-SP, Brazil. Analysis and interpretation of data, statistics analysis, critical revision, final approval.

Purpose: To create a question and answer tool on patents on EMHO.

Methods: Was used the Thinking Design methodology divided into four phases: Discovery, Definition, Development and Delivery. Discovery Phase: Desk research was carried out in: SciELO, Pubmed, LILACS, Google and Google Scholar. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000008DOI Listing
February 2019

Ramipril can alleviate the accumulation of renal mesangial matrix in rats with diabetic nephropathy by inhibiting insulin-like growth factor-11.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000007. Epub 2019 Feb 14.

Master, Department of Nephrology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China. Acquisition of data.

Purpose: To investigate the impact of Ramipril (RAM) on the expressions of insulin-like growth factor-1 (IGF-1) and renal mesangial matrix (RMM) in rats with diabetic nephropathy (DN).

Methods: The Sprague Dawley rats were divided into normal control (NC) group (n = 12), DN group (n = 11), and DN+RAM group (n = 12). The ratio of renal weight to body weight (RBT), fasting blood glucose (FBG), HbA1c, 24-h urine protein (TPU), blood urea nitrogen (BUN), creatinine (Cr), renal pathological changes, the levels of IGF-1, fibronectin (FN), type IV collagen (Col-IV), and matrix metalloproteinases (MMP)-2 were compared among the groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000007DOI Listing
February 2019
1 Read

The effect of hirudin on antagonisting thrombin induced apoptosis of human microvascular endothelial cells1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000006. Epub 2019 Feb 14.

MD, Department of Plastic and Aesthetic Surgery, The First Affiliated Hospital of Guangxi Medical University, China. Analysis and interpretation of data, critical revision.

Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis.

Methods: Human microvascular endothelial cells (HMVECs) cultured in the third and fifth generations were used. HMVECs were divided into normal group, thrombin group (T group), natrual hirudin group (H group), thrombin + natrual hirudin group (T + H group), AG490 group, thrombin + AG490 group (T + AG490 group), natrual hirudin + AG490 group (H + AG490 group), thrombin + natural hirudin + AG490 (T + H + AG490 group). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000006DOI Listing
February 2019

The role of PI3K/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000005. Epub 2019 Feb 14.

MD, Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Hubei, China. Critical revision.

Purpose: To investigate the role of PI3k/Akt signal pathway in the protective effects of propofol on intestinal and lung injury induced by intestinal ischemia/reperfusion(I/R).

Methods: Male Sprague-Dawley rats were subjected to 45 min of ischemia by occluding the superior mesenteric artery and to 2h of reperfusion to establish the model of I/R. Twenty four rats were randomly divided into four groups: Sham, intestinal I/R (II/R), propofol (P), wortmannin (W). Read More

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http://dx.doi.org/10.1590/s0102-865020190010000005DOI Listing
February 2019
2 Reads

Metronidazole concentration in the bloodstream following its topical application, at different concentration levels, on experimental skin wounds during healing by secondary intention1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000004. Epub 2019 Feb 14.

Associate Professor, Department of Surgery, and Permanent Instructor, Postgraduate in Surgical Medicine, UFPR, Curitiba-PR, Brazil. Technical procedures.

Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model.

Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000004DOI Listing
February 2019
4 Reads

LBP reduces theinflammatory injuryof kidney in septic rat and regulates the Keap1-Nrf2∕ARE signaling pathway1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000003. Epub 2019 Feb 14.

PhD, Department of Anesthesiology, Renmin Hospital of Wuhan University, China. Technical procedures, final approval.

Purpose: To investigate the influence of lycium barbarum polysaccharides (LBP), a functional derivative from lycium barbarum, on septic kidney injury.

Methods: The SD male rats were randomly divided into 8 groups. The concentration of IL-1β, IL-6, IL-8, TNF-α, NF-κB and ROS, in kidney cortex homogenates after 12 h treatments were determined by enzyme-linked immunosorbent assay and ROS test kit, respectively. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000003DOI Listing
February 2019
3 Reads

Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000002. Epub 2019 Feb 14.

Full Professor, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, School of Medicine, USP, Ribeirao Preto-SP, Brazil. Design, intellectual and scientific content of the study; manuscript preparation, critical revision, final approval.

Purpose: To evaluate the effects of food restriction on fracture healing in growing rats.

Methods: Sixty-eight male Wistar rats were assigned to two groups: (1) Control and (2) Dietary restriction. After weaning the dietary restricted animals were fed ad libitum for 42 days with 50% of the standard chow ingested by the control group. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000002DOI Listing
February 2019
1 Read

An experimental study of exenatide effects on renal injury in diabetic rats1.

Acta Cir Bras 2019 Feb 14;34(1):e20190010000001. Epub 2019 Feb 14.

Master, Second Department of Endocrinology, Tai'an Central Hospital, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effects of exenatide on renal injury in streptozotocin-induced diabetic rats.

Methods: Fifty SD rats were randomly divided into normal control, model, exenatide-1, exenatide-2 and exenatide-3 groups, 10 rats in each group. The diabetic nephropathy model was constructed in later 4 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020190010000001DOI Listing
February 2019
15 Reads

Erratum: The effect of metyrosine on oxidative gastric damage induced by ischemia/reperfusion in rats. Biochemical and histopathological evaluation.

Authors:

Acta Cir Bras 2019 02 14;34(1):e20180308ERRATUM. Epub 2019 Feb 14.

[This corrects the article doi: 10.1590/s0102-865020180030000008]. Read More

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http://dx.doi.org/10.1590/s0102-865020180030000008ERRATUMDOI Listing
February 2019

Response time in the emergency services. Systematic review.

Acta Cir Bras 2018 Dec;33(12):1110-1121

PhD, Full Professor, Department of Surgery, UFRN, Natal-RN, Brazil. Design of the study, interpretation and analysis of data, manuscript writing, critical revision.

The growth of the urban population raises concern about municipal public managers in the sense of providing emergency medical services (EMS) that are aligned with the needs of prehospital emergency medical care demanded by the population. The literature review aims at presenting the response time of emergency medical services in several parts of the world and discussing some factors that interfere in the result of this indicator such as GDP (Gross Domestic Product) percentage spent on health and life expectancy of countries. The study will also show that in some of the consulted articles, authors suggest to EMS recommendations for decreasing the response time using simulations, heuristics and metaheuristics. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000009DOI Listing
December 2018
5 Reads

Correlation between the values of circulating blood elements with the size of spleen in the presence of schistosomal splenomegaly.

Acta Cir Bras 2018 Dec;33(12):1103-1109

PhD, Associate Professor, Department of Surgery, School of Medicine, UFMG, Belo Horizonte-MG, Brazil. Scientific, intellectual, conception and design of the study; acquisition, analysis and interpretation of data; technical procedures; statistical analysis; manuscript preparation and writing; critical revision.

Purpose: To evaluate a possible relationship between the size of the spleen and values of circulating blood elements in patients with schistosomatic splenomegaly.

Methods: ixty one patients with hepatosplenic schistosomiasis mansoni underwent a clinical exam and peripheral venous blood was collected for a hemogram. The erythrocyte, hemoglobin, hematocrit, leukocyte, and platelet values were determined. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000008DOI Listing
December 2018
4 Reads

The role of ischemic preconditioning in gene expression related to inflammation in a rat model of intestinal ischemia-reperfusion injury.

Acta Cir Bras 2018 Dec;33(12):1095-1102

PhD, Associated Professor, Surgical Technique and Experimental Surgery, UNIFESP, Sao Paulo-SP, Brazil. Manuscript preparation, final approval.

Purpose: To investigate the gene expression related to inflammation on mice subjected to intestinal ischemia and reperfusion (I/R) and treated with ischemic preconditioning (IPC).

Methods: Thirty rats (EPM-Wistar), distributed in five groups of six animals each, were underwent anesthesia and laparotomy. The ischemia time was standardized in 60 minutes and the reperfusion time 120 minutes. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000007DOI Listing
December 2018
1 Read
0.570 Impact Factor

Influence of tramadol on functional recovery of acute spinal cord injury in rats.

Acta Cir Bras 2018 Dec;33(12):1087-1094

PhD, Full Professor, Institute of Health and Animal Production, UFRA, Belem-PA, Brazil. Conception, design, intellectual and scientific content of the study; critical revision, final approval.

Purpose: To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.

Methods: Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000006DOI Listing
December 2018
7 Reads

Experimental model for transforaminal endoscopic spine.

Acta Cir Bras 2018 Dec;33(12):1078-1086

PhD, Division of Neurosurgery and Pediatric Neurosurgery, Department of Surgery and Anatomy, Hospital Universitário, Ribeirao Preto Medical School, USP, Ribeirao Preto-SP, Brazil. Critical revision, final approval.

Purpose: To validate the porcine spine as a model for learning and practicing transforaminal percutaneous endoscopic lumbar procedures (TF-PELP).

Methods: TF-PELP was performed in three porcine cadaver lumbar spine levels. Anatomical features of the current cadaver were compared to human and porcine spines. Read More

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December 2018
12 Reads

Alprostadil attenuates myocardial ischemia/reperfusion injury by promoting antioxidant activity and eNOS activation in rats.

Acta Cir Bras 2018 Dec;33(12):1067-1077

MD, Department of Cardiovascular Medicine, First Hospital, Jilin University, Changchun, Jilin, P.R. China. Conception and design of the study, critical revision, final approval.

Purpose: To investigate the effect of alprostadil on myocardial ischemia/reperfusion (I/R) in rats.

Methods: Rats were subjected to myocardial ischemia for 30 min followed by 24h reperfusion. Alprostadil (4 or 8 μg/kg) was intravenously administered at the time of reperfusion and myocardial infarct size, levels of troponin T, and the activity of creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) in the serum were measured. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000004DOI Listing
December 2018
12 Reads

The role of atenolol in the modulation of the expression of genes encoding pro- (caspase-1) and anti- (Bcl2L1) apoptotic proteins in endothelial cells exposed to intestinal ischemia and reperfusion in rats.

Acta Cir Bras 2018 Dec;33(12):1061-1066

PhD, Full Professor, Division of Surgical Techniques and Experimental Surgery, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

Purpose: To investigate the role of atenolol in the gene expression of caspase 1 (Casp1) and Bcl2L1 on vascular endothelium of rat intestine after ischemia and reperfusion (IR).

Methods: Eighteen adult male Wistar rats were randomly divided into 3 groups (n=6): SG (Sham group): no clamping of the superior mesenteric artery; IRG: IR plus saline group: IRG+At: IR plus Atenolol group. Rats from IRG and IRG+At were subjected to 60 min of intestinal ischemia and 120 min of reperfusion. Read More

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http://dx.doi.org/10.1590/s0102-865020180120000003DOI Listing
December 2018
3 Reads
0.570 Impact Factor

Preparation of Zoledronate liposome and its impact on apoptosis of Kupffer cells in rat liver.

Acta Cir Bras 2018 Dec;33(12):1052-1060

PhD, Associate Professor, Department of General Surgery, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an, China. Conception and design of the study, critical revision.

Purpose: To establish a method for the preparation of zoledronate liposome and to observe its effect on inducing the apoptosis of rat liver Kupffer cells.

Methods: Zoledronate was encapsulated in liposomes, and then the entrapment rate was detected on a spectrophotometer. The prepared Zoledronate liposome (0. Read More

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December 2018
12 Reads

Evaluation of the therapeutic effect of methylene blue on the liver of rats submitted to ischemia and reperfusion.

Acta Cir Bras 2018 Dec;33(12):1043-1051

PhD, Full Professor, Division of Thoracic and Cardiovascular Surgery, Department of Surgery and Anatomy, FMRP-USP, Ribeirao Preto-SP, Brazil. Conception and design of the study, manuscript writing, critical revision.

Purpose: To analyze the effect of methylene blue (MB) therapy during the liver ischemia-reperfusion injury (I/R) process.

Methods: Thirty-five male Wistar rats were used, (70%) submitted to partial ischemia (IR) or not (NIR) (30%) were obtained from the same animal. These animals were divided into six groups: 1) Sham (SH), 2) Sham with MB (SH-MB); 3) I/R, submitted to 60 minutes of partial ischemia and 15 minutes of reperfusion; 4) NI/R, without I/R obtained from the same animal of group I/R; 5) I/R-MB submitted to I/R and MB and 6) NI/R-MB, without I/R. Read More

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December 2018
14 Reads

The cardiopulmonary bypass and cancer dissemination puzzle1.

Acta Cir Bras 2018 Nov;33(11):1037-1042

Full Professor, Surgery and Anatomy Department, FMRP-USP, Ribeirao Preto-SP, and Department of Gastroenterology, Medical School, USP, Sao Paulo-SP, Brazil. Critical revision.

Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patients under cardiopulmonary bypass (CPB) cardiac surgery. Also, the benefits, and risks, regarding long-term survival, have not yet been established. Therefore, cardiac surgery morbimortality may be superior in patients with cancer disease. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000010DOI Listing
November 2018
18 Reads

Absorbable suture. Best aesthetic outcome in cesarian scar1.

Acta Cir Bras 2018 Nov;33(11):1027-1036

PhD, Associate Professor, Translational Surgery Post Graduate Program, Universidade Federal de São Paulo (UNIFESP), and Professional Masters in Sciences Applied to Health, UNIVÁS, Pouso Alegre-MG, Brazil. Interpretation and analysis of data, critical revision.

Purpose: To compare two suture threads, poliglecaprone 25 and nylon, used as intradermal suture for skin closure in women undergoing their first cesarean section.

Methods: This is a randomized clinical trial. A total of 60 women undergoing their first cesarean section were enrolled and prospectively assessed. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000009DOI Listing
November 2018
16 Reads

Adipose tissue derived mesenchymal stem cell transplantation in the treatment of ischemia/reperfusion induced acute kidney injury in rats. Application route and therapeutic window1.

Acta Cir Bras 2018 Nov;33(11):1016-1026

Veterinay Medical, Animal Experimentation Division, Clinical Hospital, Universidade Federal do Rio Grande do Sul (UFRS), Porto Alegre-RS, Brazil. Substantive scientific and intellectual contributions to the study, critical revision.

Purpose: To evaluate renal repair in rats who had renal infarction induced by the obstruction of blood flow in the renal artery and were treated with transplantation of adipose tissue derived mesenchymal stem cell.

Methods: 16-week-old Wistar rats (n=72) were used, submitted to celiotomy and had of the renal artery and vein clipped for 24 hours. The animals were randomly assigned to 10 experimental homogeneous groups, corresponding to the treatments with phosphate-buffered saline (PBS) or adipose tissue derived mesenchymal stem cell (ADSC), duration of application (24 or 48 hours), and site of transplantation (lateral vein of the tail or intrarenal). Read More

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http://dx.doi.org/10.1590/s0102-865020180110000008DOI Listing
November 2018
3 Reads

Healing effect of andiroba-based emulsion in cutaneous wound healing via modulation of inflammation and transforming growth factor beta 31.

Acta Cir Bras 2018 Nov;33(11):1000-1015

MD, Postgraduate Program in Surgical Science, Department of Surgery, School of Medicine, UFRJ, Rio de Janeiro-RJ, Brazil. Manuscript writing, critical revision, final approval.

Purpose: To evaluate the effects and mechanisms of andiroba-based emulsion (ABE) topical treatment on full-thickness cutaneous wounds in rats.

Methods: The wounds were harvested on days 3, 7, 15, and 20 post-surgery. Wound contraction rate, quantitative immunohistochemistry [macrophages, myofibroblasts, capillaries, collagens (col) I and III, transforming growth factor β3β (TGFβ3)], and tensile strength were assessed. Read More

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November 2018
18 Reads

Knockdown of transglutaminase-2 prevents early age-induced vascular changes in mice1.

Acta Cir Bras 2018 Nov;33(11):991-999

PhD, Associate Professor, Division of Surgical Techniques and Experimental Surgery, Department of Surgery, UNIFESP, Sao Paulo-SP, Brazil. Conception and design of the study, critical revision, final approval.

Purpose: To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes.

Methods: Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure (MAP) was measured in awake mice using tail-cuff system. Thoracic aortas were excised for evaluation of endothelial dependent vasodilation (EDV) by wire myography, as well as histological analyses. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000006DOI Listing
November 2018
2 Reads
0.570 Impact Factor

Effectual components of Polygonum ciliinerve protects against Staphylococcus aureus infection with immunomodulatory functions in C57BL/6 mice1.

Acta Cir Bras 2018 Nov;33(11):983-990

Graduate student, Department of Chinese Materia Medica, Shanxi University, Traditional Chinese Medicine, Shanxi, China. Technical procedures, acquisition of data.

Purpose: To investigate the efficacy and mechanisms of root tuber of Polygonum ciliinerve (Nakai) ohwi (rPC) which has been used to treat bacterial infection in traditional Chinese medicine.

Methods: With the mouse model of Staphylococcus aureus (S. aureus) pneumonia, the phenotype of rPC treated mice, including body weight, mortality, lung slices and bacterial burden were evaluated. Read More

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November 2018
20 Reads

Hepatic retractor in an ex vivo model1.

Acta Cir Bras 2018 Nov;33(11):975-982

MD, Holy House of Mercy of Fortaleza, Professional Master's Degree Program in Minimally Invasive Technology and Simulation in Health, UNICHRISTUS, Fortaleza-CE, Brazil. Conception and design of the study, interpretation and analysis of data, critical revision, final approval.

Purpose: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE).

Methods: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000004DOI Listing
November 2018
16 Reads

Effects of different periods of gastric ischemia on liver as a remote organ1.

Acta Cir Bras 2018 Nov;33(11):964-974

Associate Professor, Department of Surgery, Faculty of Medicine, Faculdade Evangélica do Paraná (FEPAR), Curitiba-PR, Brazil. Conception and design of the study, critical revision.

Purpose: To evaluate the hepatic changes associated with gastric ischemia.

Methods: Thirty male rabbits were studied, distributed in 3 groups (n=10). Group 1: ligature and section of the gastric vasculature and removal of the liver after three hours; Group 2: ligature and section of the gastric vasculature and removal of the liver after 6 hours; Group 3: ligature and section of the gastric vasculature and removal of the liver after 12 hours. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000003DOI Listing
November 2018
12 Reads

Prevention of rocuronium induced mast cell activation with prophylactic oleuropein rich diet in anesthetized rabbits1.

Acta Cir Bras 2018 Nov;33(11):954-963

Assistant Professor, Department of Anesthesiology and Reanimation, Medical Faculty, Canakkale Onsekiz Mart University, Turkey. Analysis and interpretation of data.

Purpose: The effect of a prophylactic oleuropein-rich diet before anesthesia accompanied by the widely-used steroid-based neuromuscular drug rocuronium on mast cell activation was investigated in the study.

Methods: 14 rabbits used in the study. The rabbits in the oleuropein group were given oleuropein-rich extract added to the animals' water at doses of 20 mg/kg oleuropein for 15 days orally. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000002DOI Listing
November 2018
14 Reads

Oxymatrine alleviates periodontitis in rats by inhibiting inflammatory factor secretion and regulating MMPs/TIMP protein expression1.

Acta Cir Bras 2018 Nov;33(11):945-953

MS, Department of Stomatology, Guangzhou Hospital of Integrated Traditional and Western Medicine, Guangzhou, China. Design of the study, critical revision, final approval.

Purpose: To investigate the effect of oxymatrine on periodontitis in rats and related mechanism. Methods: Ninety SD rats were divided into control, model, 10, 20 and 40 mg/kg oxymatrine and tinidazole groups. The periodontitis model was established in later 5 groups. Read More

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http://dx.doi.org/10.1590/s0102-865020180110000001DOI Listing
November 2018
3 Reads