Acta Chromatogr 2016 2;28(3):373-385. Epub 2015 Nov 2.
Department of Chemistry, Lafayette College, Easton, Pennsylvania, United States of America.
Prions of the baker's yeast allow for the inheritance of complex traits based solely on the acquisition of cytoplasmic protein aggregates and confer distinctive phenotypes to the cells which harbor them, creating heterogeneity within an otherwise clonal cell population. These phenotypes typically arise from a loss-of-function of the prion-forming protein that is unable to perform its normal cellular function(s) while sequestered in prion amyloid aggregates, but the specific biochemical consequences of prion infection are poorly understood. To begin to address this issue, we initiated a direct investigation into the potential control that yeast prions exert over fungal lipid content by utilizing the prions  and , the first two prions discovered in yeast. Read More