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Biochim Biophys Acta Gen Subj 2020 Jul 4:129677. Epub 2020 Jul 4.

Institute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, Poland.

Background: The process of malignant transformations of many tumour cases is still unclear and more specific experimental approaches are necessary. The detailed identification of the pathological changes may help in the therapy progression through the development of drugs with more selective action.

Methods: In this study, the AFM-IR nanospectroscopy was applied for the first time to the pleomorphic adenoma (TM) and the marginal tissue characterizations. Read More

Biochim Biophys Acta Gen Subj 2020 Jul 4:129680. Epub 2020 Jul 4.

Chemical Biology Unit, Institute of Nano Science and Technology, Habitat Centre, Sector- 64, Mohali, Punjab 160062, India. Electronic address:

Background: Bacterial microcompartment represents the only reported category of prokaryotic organelles that are capable of functioning as independent bioreactors. In this organelle, a biochemical pathway with all the enzyme machinery is encapsulated within an all protein shell. The shell proteins and the enzymes have distinct structural features. Read More

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, Massachusetts, 02215. Electronic address:

Tensional homeostasis is widely recognized to exist at the length scales of organs and tissues, but the cellular length scale mechanism for tension regulation is not known. In this study, we explored whether tensional homeostasis emerges from the behavior of the individual focal adhesion (FA), which is the subcellular structure that transmits cell stress to the surrounding extracellular matrix. Past studies have suggested that cell contractility builds up until a certain displacement is achieved, and we thus hypothesized that tensional homeostasis may require a threshold level of substrate displacement. Read More

Acta Biomater 2020 Jul 4. Epub 2020 Jul 4.

School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China; National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou 510006, China; Sino-Singapore International Joint Research Institute, Guangzhou, 510555, China. Electronic address:

Self-healing hydrogels can heal themselves on the damaged sites, which opens up a fascinating way for enhancing lifetimes of materials. Polypeptide/poly(amino acid) is a class of polymers in which natural amino acid monomers or derivatives are linked by amide bonds with a stable and similar secondary structure as natural proteins (α-helix or β-fold). They have the advantages of nontoxicity, biodegradability, and low immunogenicity as well as easy modification. Read More

Acta Trop 2020 Jul 4:105619. Epub 2020 Jul 4.

Grupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Chikungunya virus (CHIKV) is a zoonotic arthropod-borne virus that has caused several outbreaks in tropical and subtropical areas worldwide during the last 50 years. The virus is known to target different human cell types throughout the course of infection including epithelial and endothelial cells, fibroblasts, primary monocytes and monocyte-derived macrophages (MDMs). The two latter are phagocytic cell populations of the innate immune system which are involved in some aspects of CHIKV pathogenesis. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Department of Gastrointestinal Surgery, Yijishan Hospital of Wannan Medical College, Wuhu 241000, China.

HEAT repeat-containing protein 1 (HEATR1) is related to the progression of several cancers. However, the role of HEATR1 in gastric cancer (GC) remains unknown. In the present study, we aimed to detect the expression of HEATR1 in GC and identify its role. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Ministry of Education Key Laboratory of Protein Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China.

Biomineralization, especially shell formation, is a sophisticated process regulated by various matrix proteins. Pinctada fucata chitinase-like protein 1 (Pf-Clp1), which belongs to the GH18 family, was discovered by our group using in-depth proteomic analysis. However, its function is still unclear. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Department of Emergency Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China.

Acute aortic dissection (AAD) is a cardiovascular emergency caused by the formation of hematoma in the middle layer of the aortic wall. Adiponectin (APN) is an adipose tissue-specific protein that has anti-inflammation and anti-atherosclerosis functions. Pyroptosis, as an inflammatory cell death, depends on the activation of caspase1, while nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) is a typical representative of the pyroptosis pathway. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Department of Inspection, The First People's Hospital of Changde City, Changde 415003, China.

Acta Microbiol Immunol Hung 2020 Jul 6. Epub 2020 Jul 6.

1Department of Medical Microbiology, Medical School, University of Pecs, Pecs, Hungary.

Infection is one of the most feared hospital-acquired complications. Infusion therapy is frequently administered through a central line. Infusions facilitating bacterial growth may be a source of central line-associated bloodstream infections. Read More

Acta Odontol Scand 2020 Jul 7:1-10. Epub 2020 Jul 7.

Institute of Dentistry, University of Turku, Turku, Finland.

A systematic review of published data was conducted with the aim of assessing effects of xylitol and erythritol consumption on levels of mutans streptococci (MS) and the oral microbiota. Electronic and hand searches were performed to find clinical microbiological studies concerning the consumption of xylitol and erythritol chewing gum or candies, and published between 2000 and 2019. Prospective randomized controlled clinical trials conducted in healthy subjects were included in the review. Read More

Acta Otolaryngol 2020 Jul 7:1-8. Epub 2020 Jul 7.

Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital & Research Center, Lahore, Pakistan.

Incidence of thyroid gland invasion in advanced laryngeal cancers is low. Ipsilateral or total thyroidectomy along with total laryngectomy has been controversial and there has been no consensus over the management of thyroid gland in advanced laryngeal cancers. To determine the frequency of thyroid gland invasion in locally advanced laryngeal squamous cell carcinoma and the risk factors associated with it. Read More

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6873-6880

Department of Emergency, Weihai Municipal Hospital, Shandong University, Weihai, China.

Objective: To explore the correlation between angiotensin II type 1 receptor (AT1R) gene polymorphism and epilepsy secondary to cerebral infarction and its significance for the diagnosis of this disease.

Patients And Methods: A total of 200 patients with epilepsy secondary to cerebral infarction were enrolled from our hospital as observation group, and 200 patients without epilepsy after cerebral infarction as control group. Genomic deoxyribonucleic acids (DNAs) were extracted from the peripheral blood of the subjects, and the polymorphic regions at AT1R gene loci rs380400, rs1799870, rs12721273, and rs55707609 were amplified via polymerase chain reaction (PCR) and sent to the company for sequencing. Read More

Acta Anaesthesiol Scand 2020 Jul 6. Epub 2020 Jul 6.

Department of palliative medicine, Akershus University Hospital, Lørenskog, Norway.

Background: The anaesthetic propofol is often mentioned as a drug that can be used in palliative sedation. The existing literature of how to use propofol in palliative sedation is scarce, with lack of information about how propofol could be initiated for palliative sedation, doses and treatment outcomes.

Aim: To describe the patient population, previous and concomitant medication and clinical outcome when propofol was used for palliative sedation. Read More

Acta Neurol Scand 2020 Jul 6. Epub 2020 Jul 6.

Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Objectives: To investigate the action of cannabinoids on spasticity and pain in secondary progressive multiple sclerosis, by means of neurophysiological indexes.

Material And Methods: We assessed 15 patients with progressive MS (11 females) using clinical scales for spasticity and pain, as well as neurophysiological variables (H/M ratio, cutaneous silent period or CSP). Testing occurred before (T0) and during (T1) a standard treatment with an oral spray containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Read More

Acta Neurol Scand 2020 Jul 6. Epub 2020 Jul 6.

Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: To investigate the effects of COVID-19 pandemic on patients' perceptions of hardship in obtaining their drugs and if this pandemic and the social restrictions in response to that has resulted in any changes in their seizure control status. We also investigated factors potentially associated with the perceptions of difficulty in obtaining their drugs (e.g. Read More

Mikrochim Acta 2020 Jul 6;187(8):427. Epub 2020 Jul 6.

Institute of Chemistry, Saratov State University, Astrakhanskaya 83, 410012, Saratov, Russia.

A noninstrumental rapid test for folic acid (FA) detection with visual results evaluation utilizing bright water-stable AgInS/ZnS (AIS/ZnS) quantum dots (QDs) is reported . AIS/ZnS QDs are hydrophilic photostable nanocrystals with size < 7 nm and emission in the visible range. They were synthesized directly in the water phase by a simple method compared to the synthesis of other QDs and conjugated with monoclonal antibodies specific for FA via ligand carboxyl groups. Read More

Acta Neurol Belg 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric Neurology, Faculty of Medicine, Mersin University, 33010, Yenisehir/Mersin, Turkey.

The objective of the study is to evaluate the clinical and neuroradiological findings, the risk factors for recurrence and the prognosis in patients with posterior reversible encephalopathy syndrome developed secondary to acute hypertension in children. The study was conducted between 2008 and 2019 at Mersin University Faculty of Medicine. A total of 49 episodes were evaluated retrospectively in 38 patients with PRES secondary to acute hypertension. Read More

Acta Neurol Belg 2020 Jul 6. Epub 2020 Jul 6.

Department of Diagnostic Imaging Unit of Neuroradiology, Istituto Ospedaliero Fondazione Poliambulanza, Via Leonida Bissolati 57, 25124, Brescia, Italy.

Acta Neurol Belg 2020 Jul 6. Epub 2020 Jul 6.

Laboratory for Epilepsy Research, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.

Epilepsy affects 50 million patients and their caregivers worldwide. Devices that facilitate the detection of seizures can have a large influence on a patient's quality of life, therapeutic decisions and the conduct of clinical trials with anti-epileptic drugs. This article provides an up-to-date overview and comparison between wearable seizure detection devices (WSDDs), taking into account the newly proposed standards for testing and clinical validation of devices. Read More

Mikrochim Acta 2020 Jul 6;187(8):429. Epub 2020 Jul 6.

School of Materials Science and Engineering, University of New South Wales, Sydney, NSW, 2052, Australia.

A glassy carbon electrode was functionalized by MoO nanoparticle-decorated multiwalled carbon nanotubes (MWCNTs) and examined as a working electrode in oxyfluorfen (OXY) detection by differential pulse stripping voltammetry (DPSV). Measurement parameters were as follows: initial potential - 0.1 V, end potential + 0. Read More

Acta Neurochir (Wien) 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurosurgery, Mayo Clinic, 200 First St. SW, Gonda 8-214, Rochester, MN, 55905, USA.

Background: Perineural spread (PNS) is an emerging mechanism for progressive, non-traumatic brachial plexopathy. We aim to summarize the pathologies (tumor and infection) shown to have spread along or to the brachial plexus, and identify the proposed mechanisms of perineural spread.

Methods: A focused review of the literature was performed pertaining to pathologies with identified perineural spread to the brachial plexus. Read More

Mikrochim Acta 2020 Jul 6;187(8):430. Epub 2020 Jul 6.

Institute of Low Temperature and Structure Research, Polish Academy of Sciences, P.O. Box 1410, 50-950, Wrocław, Poland.

Sorptive and selective mini-membranes based on TiO directly synthesized onto cellulose filters (TiO@cellulose) have been developed. The in situ synthesis of TiO@cellulose applied is simple and economically advantageous. The obtained membranes can be useful for (1) separating arsenic(V) and selenium(IV) from other ions and organic matter, (2) speciation of arsenic and selenium, and (3) determining ulratraces of these ions in water samples. Read More

Mikrochim Acta 2020 Jul 7;187(8):431. Epub 2020 Jul 7.

Prof. Massoumi Laboratory, Department of Chemistry, College of Sciences, Shiraz University, Shiraz, 71454, Iran.

A field-applicable colorimetric assay for fast detection of notorious explosive triacetone triperoxide (TATP) has been developed through the selective irreversible oxidation of 3, 3'-diaminobenzidine by hydrogen peroxide (HP) liberated during the acidic hydrolysis/degradation of TATP in the presence of MnO nanozymes. The generated HP was detected by probing the absorbance of the product (indamine polymer) of the 3, 3'-diaminobenzidine (DAB) oxidation reaction at 460.0 nm. Read More

Mikrochim Acta 2020 Jul 6;187(8):428. Epub 2020 Jul 6.

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, People's Republic of China.

A nanocomposite consisting of CeO nanoparticle-decorated MnO nanospheres (CeO@MnO) was synthesized for the first time via a hydrothermal method. CeO@MnO was exploited to construct an electrochemical assays for detecting HO and prostate-specific antigen (PSA) with square wave voltammetry (SWV). The electrochemical results proved that CeO@MnO owned a better electrocatalytic effect towards HO reduction than pure MnO NS and CeO NP due to the synergistic effect between MnO NS and CeO NP. Read More

Acta Neuropathol 2020 Jul 6. Epub 2020 Jul 6.

Department of Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, 6229 ER, Maastricht, The Netherlands.

In the original article, the panels "Brain organoids" and "Transgenics" were included in Fig. 5 without permission. Read More

Acta Biochim Biophys Sin (Shanghai) 2020 Jul 7. Epub 2020 Jul 7.

Department of Medical Oncology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, China.

The treatment of triple-negative breast cancer (TNBC) relies largely on chemotherapies. However, it is frequent that TNBC patients develop resistance to the chemotherapy drugs. Generation of drug-resistant cell lines facilitates the identification of drug resistance. Read More

Acta Pharmacol Sin 2020 Jul 6. Epub 2020 Jul 6.

State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

Biochim Biophys Acta Mol Basis Dis 2020 Jul 4:165892. Epub 2020 Jul 4.

Department of Anaesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany; Septomics Research Centre, Jena University Hospital, Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. Electronic address:

Acta Neuropathol Commun 2020 Jul 6;8(1):100. Epub 2020 Jul 6.

Department of Physiology, University of Kentucky College of Medicine, 800 Rose Street Room MS519, Lexington, KY, USA.

Acta Neuropathol Commun 2020 Jul 6;8(1):99. Epub 2020 Jul 6.

Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β (Aβ) protein in the cerebral vasculature and poses a major risk factor for the development of intracerebral haemorrhages (ICH). However, only a minority of patients with CAA develops ICH (CAA-ICH), and to date it is unclear which mechanisms determine why some patients with CAA are more susceptible to haemorrhage than others. We hypothesized that an imbalance between matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) contributes to vessel wall weakening. Read More

Acta Radiol 2020 Jul 6:284185120939291. Epub 2020 Jul 6.

Department of Radiology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Renal pseudotumors appear as benign cortical hypertrophies and are typically assessed by contrast-enhanced computed tomography or magnetic resonance imaging to rule out malignancy.

Purpose: To investigate whether contrast-enhanced ultrasound (CEUS) can rule out renal neoplasm and thus potentially reduce cross-sectional imaging and further follow-up in these patients.

Material And Methods: Thirty-two patients with presumption of developmental renal pseudotumor on CEUS between June 2011 and July 2019 were retrospectively analyzed. Read More

Acta Radiol 2020 Jul 6:284185120938363. Epub 2020 Jul 6.

Department of Interventional Radiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Use of transrectal ultrasound (US)-guided biopsies improved diagnosis and treatment for patients with high prostate-specific antigen (PSA) or abnormal digital rectal exam (DRE).

Purpose: To investigate whether taking two transition zone (TZ) biopsies in addition to routine prostate double-sextant biopsies (12-cores) would improve detection rates of prostate cancer (PCa).

Material And Methods: A retrospective analysis of 1107 in a single institution database after Institutional Review Board approval, which underwent US-guided prostate biopsies from January 2014 to June 2016. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;240:118606. Epub 2020 Jun 19.

Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:

A near-infrared (NIR) colorimetric fluorescence sensor, Cy7C3, based on heptamethine cyanine dye was synthesized for determining the presence of Cu ions. The sensor showed highly sensitive fluorescence quenching toward Cu ions in acetonitrile/buffer solution at physiological pH with long emission wavelength of 718 nm. Cy7C3 also provided an excellent selectivity to Cu ions over other competing metal ions, with a low detection limit of 9 ppb, which was lower than the maximum concentration of Cu ions in drinking water of U. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 29;241:118650. Epub 2020 Jun 29.

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, PR China.

In modern biology, hydrogen polysulfides (HS, n > 1) are members of reactive sulfur species (RSS), with anti-oxidation, cell protection and redox signals in tissues and organs. Therefore, it is crucial to develop a method to monitor the changes of HS level in organisms. We designed and synthesized a ratiometric fluorescent probe for highly selective detection of HS based on the fluorescence resonance energy transfer (FRET) process. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 26;241:118649. Epub 2020 Jun 26.

Institute of Pharmacy and Pharmacology, University of South China, HengYang 421000, Hunan, China. Electronic address:

A platinum (II)-doped graphitic carbon nitride (Pt@g-CN) nanozyme was prepared in this work. Compared to g-CN, Pt@g-CN shows enhanced peroxidase-like activity. According to DFT calculations and ESR measurements, the Pt on the surface of g-CN accelerates the decomposition of HO into OH and consequently accelerates TMB oxidation. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 25;241:118639. Epub 2020 Jun 25.

Ondokuz Mayıs University, Faculty of Arts and Sciences, Physics Department, Samsun, Turkey.

The mix-ligand coordination compound, [Cu(Nal)(Phen)(HO)].(Phen).ClO. Read More

Acta Psychol (Amst) 2020 Jul 3;209:103089. Epub 2020 Jul 3.

School of Educational Sciences, Tallinn University, Narva road 25, 10120 Tallinn, Estonia. Electronic address:

Self-directed learning (SDL) is a rapidly developing trend in schools, although its prerequisites, such as children's skills and abilities to plan and monitor their own learning, have not been investigated in detail. Due to additional cognitive load it induces, SDL has been in some cases found to be detrimental for learning, especially for students with a lower cognitive capacity. With this study, we explored some of the causes for the variability in learning gains. Read More

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Center for Biomaterials and Biopathways, Department of Chemistry, Zhejiang University, Hangzhou, 310027 China; Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou, 310027 China. Electronic address:

Biomineralization, a bio-organism controlled mineral formation process, plays an important role in linking biological organisms and mineral materials in nature. Inspired by biomineralization, biomimetic mineralization is used as a bridge tool to integrate biological organisms and functional materials together, which can be beneficial for the development of diversified functional organism-material hybrids. In this review, recent progresses on the techniques of biomimetic mineralization for organism-material combinations are summarized and discussed. Read More

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Institute of Bismuth Science, College of Science, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:

Developing a multi-functional radiosensitizer with high efficiency and low toxicity remains challenging. Herein, we report a mesoporous heterostructure radiosensitizer (UCNP@NBOF-FePc-PFA) containing Lu-based upconversion nanophosphor (UCNP) and Bi-based nanomaterial loaded with iron phthalocyanine for X-ray and NIR light dual-triggered tri-modal tumor therapy. NaLuF:Yb,Tm, a Lu-based UCNP, offers radiosensitization and upconversion luminescence for optical bio-imaging. Read More

Acta Biomater 2020 Jul 3. Epub 2020 Jul 3.

Department of Biomedical Engineering, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006, China; National Engineering Research Center for Tissue Restoration and Reconstruction (NERC-TRR), Guangzhou, 510006, China; Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, South China University of Technology, Guangzhou 510006, P. R. China; Guangdong Province Key Laboratory of Biomedical Engineering, South China University of Technology, Guangzhou, 510641, China. Electronic address:

Biophysical cues (especially mechanical cues) embedded in cellular microenvironments show a critical impact on stem cell fate. Despite the capability of traditional hydrogels to mimic the feature of extracellular matrix (ECM) and tune their physicochemical properties via diverse approaches, their relatively large size not only induces biased results, but also hinders high-throughput screening and analysis. In this paper, a microgel model is proposed to recapitulate the role of 3D mechanical microenvironment on stem cell behaviors especially chondrogenesis in vitro. Read More

Biochim Biophys Acta Gene Regul Mech 2020 Jul 3:194601. Epub 2020 Jul 3.

School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; Pulmonary Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Apoptotic chromatin condensation inducer in the nucleus (also referred as Acin1) was first characterized as an RNA-binding protein involved in apoptosis. In later reports, Acin1 was identified as an auxiliary component of the exon junction complex (EJC) which is assembled throughout pre-messenger RNA splicing. In this study, results of whole-transcriptome analyses revealed reduced expressions and reprogrammed splicing profiles of Acin1 transcripts throughout development of brown adipose tissues (BATs) that execute non-shivering thermogenesis in small rodents and infants by consuming lipids. Read More

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 3:158761. Epub 2020 Jul 3.

Graduate School of Biomedical Sciences, Tokushima University, 1-78-1 Shomachi, Tokushima 770-8505, Japan; Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima 731-0153, Japan. Electronic address:

A family of glycerol-based lysolipid mediators comprises lysophosphatidic acid as a representative phospholipidic member but also a monoacylglycerol as a non-phosphorus-containing member. These critical lysolipid mediators are known to be produced from different lysophospholipids by actions of lysophospholipases C and D in mammals. Some members of the glycerophosphodiesterase (GDE) family have attracted recent attention due to their phospholipid-metabolizing activity. Read More

Biochim Biophys Acta Mol Basis Dis 2020 Jul 3:165891. Epub 2020 Jul 3.

Department of Pharmacology and Neuroscience, Texas Tech University Health Sciences Center, School of Medicine, Lubbock, TX 79430, USA. Electronic address:

Clin Chim Acta 2020 Jul 3. Epub 2020 Jul 3.

Department of Pathology, University of Virginia School of Medicine, Charlottesville VA. Electronic address:

Biochim Biophys Acta Biomembr 2020 Jul 3:183407. Epub 2020 Jul 3.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address:

Miltefosine (hexadecylphosphocholine or HePC) is an alkylphosphocholine approved for the treatment of visceral and cutaneous Leishmaniasis. HePC exerts its effect by interacting with lipid membranes and affecting membrane-dependent processes. The molecular geometry of HePC suggests that the pharmacological function of HePC is to alter membrane curvature. Read More

Acta Trop 2020 Jul 3:105618. Epub 2020 Jul 3.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah 26666, United Arab Emirates.

Acanthamoeba spp. are free living amoeba (FLA) which are widely distributed in nature. They are opportunistic parasites and can cause severe infections to the eye, skin and central nervous system. Read More

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Women´s and Children`s Health, Karolinska Institute, Stockholm, Sweden.

Aim: This Swedish study evaluated whether the severity of retinopathy of prematurity (ROP) in extremely preterm infants was related to their overall outcome in young adulthood.

Methods: We followed 39 individuals born 1988-93 at less than 28 gestational weeks, included in the Stockholm Neonatal Project. 19 were treated for severe ROP and 20 had no or mild ROP. Read More

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatrics (Neonatal Division), McMaster University, Hamilton, Ontario, Canada.

The pandemic is a stressful time for everyone, including mothers and healthcare providers who are concerned about the best and safest way to feed babies born to mothers with suspected or confirmed COVID-19. There is lack of consensus regarding mother-infant contact, unless the mother definitely has COVID-19 and even then there is a distinct lack of data to devise protocols for everyday clinical practice.. Read More

Acta Paediatr 2020 Jul 6. Epub 2020 Jul 6.

Immunology Section, Ciudad Real University General Hospital, Ciudad Real, Spain.

The first description on the association of coeliac disease (CD) with allergic conditions dates in the 1970s, when was found the co-occurrence of asthma, eczema and rhinitis in adult patients with CD. Later, this likely connection was screened both in paediatric and adult populations, although with conflicting results (1,2). Hence, the relationship between CD and allergy is scarcely known. Read More