655,767 results match your criteria Acta Chimica Sinica[Journal]


The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

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http://dx.doi.org/10.1159/000498889DOI Listing

The Assessment of Serum Drug Levels to Diagnose Non-Adherence in Stable Chronic Heart Failure Patients.

Acta Medica (Hradec Kralove) 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.

Background: The aim of our study was to evaluate the prevalence of drug non-adherence in stable chronic heart failure (CHF) patients using serum drug levels (SDL) assessment.

Methods: CHF patients were prospectively enrolled during scheduled outpatient visit. Except standard procedures an unanticipated blood sampling for the SDL assessment was obtained. Read More

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http://dx.doi.org/10.14712/18059694.2019.46DOI Listing

Oct angiography compared to fluorescein angiography, indocyanine green angiography and optical coherence tomography in the detection of choroidal neovascularization in pigment epithelial detachment.

Acta Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Ophthalmology, Federal University of Goias, Goiania, Goias.

Purpose: To evaluate the agreement between multimodal imaging-MI (fluorescein angiography, indocyanine green angiography, optical coherence tomography) and optical coherence tomography angiography (OCTA) in the detection of choroidal neovascularization (CNV) in patients with pigment epithelial detachment with subretinal/intraretinal fluid (PED+F) compared to patients with PED without subretinal/intraretinal fluid (PED-F).

Methods: Twenty-two eyes of 15 patients were divided into two groups (PED+F and PED-F). All patients underwent MI and OCTA with manual and automatic segmentation. Read More

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http://dx.doi.org/10.1111/aos.14117DOI Listing

Using simple interrupted Suture Anastomoses may impair Translatability of experimental Rodent oesophageal Surgery.

Acta Chir Belg 2019 Apr 23:1-14. Epub 2019 Apr 23.

b Department of Paediatric Surgery , Universitätsmedizin Mainz der Johannes Gutenberg-Universität , Langenbeckstraße 1 , D-55131 Mainz , Germany.

Background/purpose: Irreproducibility and missing translatability are major drawbacks in experimental animal studies. Hand-sewn anastomoses in oesophageal surgery are usually continuous, whereas those in experimental oesophageal surgery are widely performed using the simple interrupted technique. It has been implicated to be inferior in tolerating anastomotic tension, which we aimed to test in rats due to their importance as an animal model in oesophageal surgery. Read More

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Lateral neck cyst as initial presentation of thyroid malignancy.

Acta Chir Belg 2019 Apr 23:1-9. Epub 2019 Apr 23.

b Department of General and Endocrine Surgery , OLV Clinic Aalst , Aalst , Belgium.

Introduction: A mass in the lateral aspect of the neck may cause a diagnostic dilemma for the clinician. Cystic lateral neck masses in young adults are most often benign as the most frequent cause is a branchial cleft cyst. However this may be a pitfall as such a cystic mass can be a first presentation of occult malignancy. Read More

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Association between glaucoma and the risk of Alzheimer's disease: A systematic review of observational studies.

Acta Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Department of Ophthalmology, Shengjing Hospital of China Medical University, Shenyang, China.

To address inconsistency as well as investigate the relationship between glaucoma and the risk of Alzheimer's disease (AD). We systematically conducted this meta-analysis based on observational studies published up to 15 January 2018, identified from PubMed and Web of Science. Two team members independently extracted the data and assessed the quality of each included study. Read More

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http://dx.doi.org/10.1111/aos.14114DOI Listing

Incidence of chronic pain 6 y after major trauma.

Acta Anaesthesiol Scand 2019 Apr 22. Epub 2019 Apr 22.

Department of Anaesthesiology, Oslo University Hospital, Oslo, Norway.

Background: Life saving measures is the main focus in the initial treatment of major trauma. In surviving patients, chronic pain may be a serious problem, but the long term incidence and potential risk factors are not very well studied.

Methods: All adult trauma patients included in the institutional trauma registry in 2007 were assessed for eligibility. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/aas.13380
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http://dx.doi.org/10.1111/aas.13380DOI Listing
April 2019
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Rational application of antibiotics-The influence of anaesthetists' gender on self-confidence and knowledge.

Acta Anaesthesiol Scand 2019 Apr 22. Epub 2019 Apr 22.

Department of Urology, St. Elisabeth-Klinikum Straubing, Straubing, Germany.

Background: High rates of multiresistant pathogens require detailed knowledge about rational utilization of antibiotics. Many physicians consider themselves uncertain about the interpretation of microbiological diagnostics. We examined whether self-confidence, self-rated knowledge, and objective knowledge regarding the use of antibiotics are associated with gender. Read More

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http://dx.doi.org/10.1111/aas.13376DOI Listing

Endogenous oligodendroglial alpha-synuclein and TPPP/p25α orchestrate alpha-synuclein pathology in experimental multiple system atrophy models.

Acta Neuropathol 2019 Apr 22. Epub 2019 Apr 22.

Center of Clinical Research, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens (BRFAA), 4 Soranou Efesiou Street, 11527, Athens, Greece.

Multiple system atrophy (MSA) is characterized by the presence of distinctive glial cytoplasmic inclusions (GCIs) within oligodendrocytes that contain the neuronal protein alpha-synuclein (aSyn) and the oligodendroglia-specific phosphoprotein TPPP/p25α. However, the role of oligodendroglial aSyn and p25α in the formation of aSyn-rich GCIs remains unclear. To address this conundrum, we have applied human aSyn (haSyn) pre-formed fibrils (PFFs) to rat wild-type (WT)-, haSyn-, or p25α-overexpressing oligodendroglial cells and to primary differentiated oligodendrocytes derived from WT, knockout (KO)-aSyn, and PLP-haSyn-transgenic mice. Read More

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http://dx.doi.org/10.1007/s00401-019-02014-yDOI Listing

Blood vessels guide Schwann cell migration in the adult demyelinated CNS through Eph/ephrin signaling.

Acta Neuropathol 2019 Apr 22. Epub 2019 Apr 22.

Institut du Cerveau et de la Moelle Epinière-Groupe Hospitalier Pitié-Salpêtrière, INSERM, U1127; CNRS, UMR 7225; Sorbonne Universités, Université Pierre et Marie Curie Paris 06, UM-75, Paris, France.

Schwann cells (SC) enter the central nervous system (CNS) in pathophysiological conditions. However, how SC invade the CNS to remyelinate central axons remains undetermined. We studied SC migratory behavior ex vivo and in vivo after exogenous transplantation in the demyelinated spinal cord. Read More

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http://dx.doi.org/10.1007/s00401-019-02011-1DOI Listing

Correction to: The origin, fate, and contribution of macrophages to spinal cord injury pathology.

Acta Neuropathol 2019 Apr 22. Epub 2019 Apr 22.

Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL, 33136, USA.

The original version of the article contains a labeling error in Fig. 2. The boxed molecular description of pro-inflammatory and anti-inflammatory macrophages were switched. Read More

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http://dx.doi.org/10.1007/s00401-019-02016-wDOI Listing

PRODIGE 7 should be interpreted with caution.

Acta Chir Belg 2019 Apr 23:1-13. Epub 2019 Apr 23.

c Department of Medical Oncology , Institut Jules Bordet, Université Libre de Bruxelles , Brussels , Belgium.

The recent presentation and abstract from the PRODIGE 7 study at ASCO 2018 on the role of hyperthermic intraperitoneal chemotherapy (HIPEC) using oxaliplatin as adjuvant treatment following cytoreductive surgery (CRS) in patients with colorectal peritoneal metastases (PM) who have received perioperative chemotherapy (PCT) has shaken the surgical community involved in the treatment of colorectal PM. Since then, two papers, an editorial and an opinion paper, have been reported in response to the results from PRODIGE 7 with opposite conclusions and perspectives. In this debate paper, we focus on methodological aspects of the PRODIGE 7 trial by pointing out several weaknesses of the study, such as inclusion criteria (PCI >16) and the power calculation, in an effort to highlight our perspective that these results should be interpreted with caution and in the context of objective information in the current literature. Read More

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Can Local Infiltration of Lidocaine Reduce the Postoperative Atrial Fibrillation Rate in Patients undergoing Lobectomy for Lung Cancer?

Acta Chir Belg 2019 Apr 23:1-16. Epub 2019 Apr 23.

b Department of Cardiology , Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital , Istanbul , Turkey.

Background: Postoperative atrial fibrillation (POAF) occurs frequently after lung cancer surgery. Unfortunately, owing to the multifactorial etiology of POAF, no single drug or intervention can prevent POAF in all cases. The effects of local interventions after lung cancer surgery are unknown. Read More

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In vivo and in vitro bioactivity of a "precursor of apatite" treatment on polyetheretherketone.

Acta Biomater 2019 Apr 19. Epub 2019 Apr 19.

Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.

We recently developed a surface treatment, "precursor of apatite" (PrA), for polyetheretherketone (PrA-PEEK) via a simple, low-temperature process aiming to achieve stronger and faster adhesion to bone. The treatment involves three steps: HSO immersion, exposure to O plasma discharge, and alkaline simulated body fluid (alkaline SBF) treatment. This method produces homogeneous fine particles of amorphous calcium phosphate on the PEEK, and we confirmed that PrA-PEEK had excellent apatite formation ability in an SBF immersion test. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17427061193028
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http://dx.doi.org/10.1016/j.actbio.2019.04.041DOI Listing
April 2019
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Blood and urine biomarkers in chronic kidney disease: An update.

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Nephrology Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia; Nephrology Department, Serdang Hospital, Selangor, Malaysia.

Introduction: Chronic kidney disease (CKD) is a silent disease. Most CKD patients are unaware of their condition during the early stages of the disease which poses a challenge for healthcare professionals to institute treatment or start prevention. The trouble with the diagnosis of CKD is that in most parts of the world, it is still diagnosed based on measurements of serum creatinine and corresponding calculations of eGFR. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193181
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http://dx.doi.org/10.1016/j.cca.2019.04.069DOI Listing
April 2019
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Serum soluble TWEAK levels in severe traumatic brain injury and its prognostic significance.

Clin Chim Acta 2019 Apr 19. Epub 2019 Apr 19.

Department of Critical Care Medicine, The First People's Hospital of Jiande City, 599 Yanzhou Main Road, Jiande 311600, China.

Background: Severe traumatic brain injury (sTBI) is characterized by a high mortality. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) participates in inflammation. We determined serum soluble TWEAK (sTWEAK) levels with respect to its prognostic ability. Read More

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http://dx.doi.org/10.1016/j.cca.2019.04.070DOI Listing

A path to cooperation between China and Mongolia towards the control of echinococcosis under the Belt and Road Initiative.

Acta Trop 2019 Apr 19. Epub 2019 Apr 19.

London School of Hygiene and Tropical Medicine, United Kingdom.

Health is the core of development. Health cooperation between countries plays a pivotal role under the 'Belt and Road' Initiative. In 2013, China launched its Belt and Road Initiative to improve the international cooperation of which health was an important component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0001706X183108
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http://dx.doi.org/10.1016/j.actatropica.2019.04.022DOI Listing
April 2019
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The London PCHF - a new postgraduate course on heart failure.

Acta Cardiol 2019 Apr 22:1-5. Epub 2019 Apr 22.

a Royal Brompton and Harefield NHS Foundation Trust , London , UK.

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http://dx.doi.org/10.1080/00015385.2019.1601908DOI Listing

Inflammation - dysregulated inflammatory response and strategies for treatment.

Authors:
K Herold R Mrowka

Acta Physiol (Oxf) 2019 Apr 22:e13284. Epub 2019 Apr 22.

Klinik für Innere Medizin III, AG Experimentelle, Nephrologie, Universitätsklinikum Jena, Jena, Germany.

Inflammation is a natural protective response to microbial infections and tissue injury. It functions to eliminate harmful stimuli and to repair damaged tissue. The inflammatory response is initiated by different inducers of exogenous and endogenous origin. Read More

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http://dx.doi.org/10.1111/apha.13284DOI Listing

Fibre hypertrophy, satellite cell and myonuclear adaptations to resistance training: Have very old individuals reached the ceiling for muscle fibre plasticity?

Acta Physiol (Oxf) 2019 Apr 22:e13287. Epub 2019 Apr 22.

Department of Laboratory Medicine, Division of Clinical Physiology, Karolinska Institutet, and Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden.

In this issue of Acta Physiologica, Karlsen et al. report original data suggesting lack of muscle fibre hypertrophy, myonuclear addition, and satellite cell pool expansion with 12 weeks of resistance training in very old (83-94-years) men and women. These findings further our understanding of muscle remodelling responses to exercise at the most advanced stages of ageing, and spur additional research on the optimization of training protocols to combat muscle loss. Read More

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http://dx.doi.org/10.1111/apha.13287DOI Listing

Prehospital assessment of suspected stroke and TIA: an observational study.

Acta Neurol Scand 2019 Apr 22. Epub 2019 Apr 22.

Centre for Prehospital Research, Faculty of Caring Science, Work Life and Social Welfare, University of Borås, Borås, Sweden.

Background: Symptoms related to stroke diverge and may mimic many other conditions.

Aims: To evaluate clinical findings among patients with a clinical suspicion of stroke in a prehospital setting and find independent predictors of a final diagnosis of stroke or transient ischemic attack (TIA) METHODS: An observational multi-centre study including nine emergency hospitals in western Sweden. All patients transported to hospital by ambulance and in whom a suspicion of stroke was raised by the EMS clinician before hospital admission during a four-month period were included. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ane.13107
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http://dx.doi.org/10.1111/ane.13107DOI Listing
April 2019
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The effect of bilateral U-sutures in pancreaticojejunostomy in 75 consecutive cases.

Acta Chir Belg 2019 Apr 22:1-13. Epub 2019 Apr 22.

a Department of General Surgery , Affiliated Hospital of Yanbian University , Yanji , Jilin 133000 , China.

Background: Various technical interventions have been suggested to decrease the frequency of postoperative pancreatic fistulas but the effect is not particularly satisfactory. We have analyzed our application of bilateral U-sutures in pancreatico- jejunostomy.

Methods: The pancreatic stump is freed over approximately 2 cm, an appropriate diameter silicone catheter with 2-4 lateral holes was inserted into the remnant pancreatic duct (>2 mm in diameter is required) over 2-3cm as a stent in 69 patients. Read More

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April 2019
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Prediction of exocrine and endocrine insufficiency after pancreaticoduodenectomy using volumetry.

Acta Chir Belg 2019 Apr 22:1-22. Epub 2019 Apr 22.

a Department of Hepatobiliary, Endocrine and Transplantation Surgery , Antwerp University Hospital , Belgium.

Objectives: The aim of this study is to evaluate the use of pancreatic volumetric assessment to predict exocrine and endocrine insufficiency after pancreaticoduodenectomy.

Methods: Thirty-seven patients who underwent pancreaticoduodenectomy were included in the study. Endocrine function was assessed in all patients without a history of diabetes using an oral glucose tolerance test. Read More

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April 2019
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Efficacy of intratympanic corticosteroid, intravenous batroxobin and combined treatment for sudden sensorineural hearing loss with type-2 diabetes.

Acta Otolaryngol 2019 Apr 22:1-7. Epub 2019 Apr 22.

a Department of Otorhinolaryngology Head and Neck Surgery , Beijing Anzhen Hospital, Capital Medical University , Beijing , China.

Background: Intratympanic corticosteroid (IC), intravenous batroxobin (IB) as the treatment for sudden sensorineural hearing loss (SSNHL) has been reported. However, the data on combination therapy (CT) was scarce.

Objective: The aim of this retrospective study was to compare the efficacy of IC, IB, and CT in the treatment of SSNHL with diabetes. Read More

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http://dx.doi.org/10.1080/00016489.2019.1592221DOI Listing

Intramural duodenal hematoma: clinical course and imaging findings.

Acta Radiol Open 2019 Apr 8;8(4):2058460119836256. Epub 2019 Apr 8.

Klinik für Radiologie, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Intramural duodenal hematoma is a rare condition. Different imaging modalities are at hand for diagnosis.

Purpose: To identify patients with intramural duodenal hematoma and report imaging findings and clinical courses. Read More

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http://dx.doi.org/10.1177/2058460119836256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456848PMC

Inclined convection in a porous Brinkman layer: linear instability and nonlinear stability.

Proc Math Phys Eng Sci 2019 Mar 13;475(2223):20180614. Epub 2019 Mar 13.

Dipartimento di Matematica e Informatica, Città Universitaria, Viale A. Doria 6, 95125 Catania, Italy.

In this article, we deal with thermal convection in an inclined porous layer modelled by the . Inertial effects are taken into account, and the physically significant rigid boundary conditions are imposed. This model is an extension of the work by Rees & Bassom (Rees & Bassom 2000 , 103-118 (doi:10. Read More

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http://dx.doi.org/10.1098/rspa.2018.0614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451983PMC

Animal models for hepatocellular carcinoma.

Biochim Biophys Acta Mol Basis Dis 2019 May 10;1865(5):993-1002. Epub 2018 Aug 10.

Centenary Institute, The University of Sydney, Newtown, New South Wales, 2042, Australia; The University of Sydney Faculty of Medicine and Health, New South Wales, 2006, Australia. Electronic address:

Hepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xenograft, or a combination of these with each other or with a metabolic insult. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.08.009DOI Listing

Outside the liver box: The gut microbiota as pivotal modulator of liver diseases.

Biochim Biophys Acta Mol Basis Dis 2019 May 6;1865(5):912-919. Epub 2018 Jul 6.

Sahlgrenska Academy, Institute of Medicine, Department of Molecular and Clinical Medicine, Wallenberg Laboratory, University of Gothenburg, S-413 45 Gothenburg, Sweden. Electronic address:

The gut microbiota affects host physiology and has evolved as an important contributor to health and disease. Gut and liver are closely connected and communicate via the portal vein and the biliary system so the liver is constantly exposed to gut-derived bacterial products and metabolites. The intestinal barrier is important for maintaining physical and functional separation between microbes in the gut and the interior of the host and disruption of the barrier function can lead to bacterial translocation and increased leakage of bacterial metabolites. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.07.004DOI Listing

Animal models of drug-induced liver injury.

Biochim Biophys Acta Mol Basis Dis 2019 May 3;1865(5):1031-1039. Epub 2018 Sep 3.

Dept. of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address:

Drug-induced liver injury (DILI) presents unique challenges for consumers, clinicians, and regulators. It is the most common cause of acute liver failure in the US. It is also one of the most common reasons for termination of new drugs during pre-clinical testing and withdrawal of new drugs post-marketing. Read More

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http://dx.doi.org/10.1016/j.bbadis.2018.08.037DOI Listing

A model-based economic evaluation of four newborn screening strategies for cystic fibrosis in Flanders, Belgium.

Acta Clin Belg 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Interuniversity Center for Health Economics Research , Vrije Universiteit Brussel , Brussels , Belgium.

Objectives: The most cost-effective newborn screening strategy for cystic fibrosis (CF) for Flanders, Belgium, is unknown. The aim of this study was to assess the cost-effectiveness of four existing newborn screening strategies for CF: IRT-DNA (immunoreactive trypsinogen, cystic fibrosis transmembrane conductance regulator (CFTR) gene mutation analysis), IRT-PAP (pancreatitis-associated protein), IRT-PAP-DNA, and IRT-PAP-DNA-EGA (extended CFTR gene analysis).

Methods: Using data from published literature, the cost-effectiveness of the screening strategies was calculated for a hypothetical cohort of 65,606 newborns in Flanders, Belgium. Read More

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https://www.tandfonline.com/doi/full/10.1080/17843286.2019.1
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http://dx.doi.org/10.1080/17843286.2019.1604472DOI Listing
April 2019
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Coombs-positive refractory acquired thrombotic thrombocytopenic purpura in a patient with chronic myelomonocytic leukemia successfully treated with rituximab.

Acta Clin Belg 2019 Apr 22:1-5. Epub 2019 Apr 22.

b Intensive Care Unit, Department of Internal Medicine , University Hospital Centre Zagreb , Zagreb , Croatia.

Objectives: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare autoimmune disorder characterized by auto-antibodies to Willebrand factor (vWF) cleaving enzyme (ADAMTS13), resulting in unusually large vWF multimers that lead to platelet aggregation, microthrombi formation and microangiopathic hemolytic anemia. Hemolysis in aTTP is mechanical; thus, direct antiglobulin test (Coombs test) is usually negative. Multiple autoimmune conditions and various auto-antibodies have been described in the context of chronic myelomonocytic leukemia (CMML). Read More

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http://dx.doi.org/10.1080/17843286.2019.1608395DOI Listing

Questions about a vegan diet should be included in differential diagnostics of neurologically abnormal infants with failure to thrive.

Authors:
A M Lund

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Departments of Paediatrics and Clinical Genetics, Juliane Marie Centre, Copenhagen University Hospital, Copenhagen, Denmark.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/apa.14805
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http://dx.doi.org/10.1111/apa.14805DOI Listing
April 2019
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Limits of cerebral near infrared spectroscopy monitoring during pre-hospital anaesthesia.

Acta Anaesthesiol Scand 2019 Apr 21. Epub 2019 Apr 21.

Anesthesiology and Surgical Critical Care Medicine Department, Tours University Hospital, Tours, France.

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http://dx.doi.org/10.1111/aas.13374DOI Listing

miR-27b-3p/MARCH7 regulates invasion and metastasis of endometrial cancer cells through Snail-mediated pathway.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 22. Epub 2019 Apr 22.

Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Ubiquitin E3 ligase membrane-associated RING-CH-type finger 7 (MARCH7), also known as axotrophin, was originally identified in mouse embryonic stem cells. MARCH7 is involved in T-cell proliferation, neuronal development, and the immune system. However, its role in endometrial cancer (EC) remains unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmz030DOI Listing

Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice.

Acta Histochem 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Second Hospital of Dalian Medical University, Dalian, 116027, People's Republic of China. Electronic address:

Sevoflurane is a widely used inhaled anesthetic, which triggers neuroapoptosis and oxidative damage in the developing central nervous system and cognitive dysfunction later in life. However, no effective therapeutic strategy for sevoflurane-induced deleterious effects is well developed. The purpose of the present study was to explore whether luteoline could attenuate neonatal sevoflurane exposure-triggered neurotoxicity. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.04.004DOI Listing

Urokinase-type plasminogen activator (uPA) is not essential for epithelial sodium channel (ENaC)-mediated sodium retention in experimental nephrotic syndrome.

Acta Physiol (Oxf) 2019 Apr 21:e13286. Epub 2019 Apr 21.

Department of Internal Medicine, Division of Endocrinology Division of Endocrinology Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University Hospital Tübingen, Germany.

Aim: In nephrotic syndrome, aberrantly filtered plasminogen (plg) is converted to active plasmin by tubular urokinase-type plasminogen activator (uPA) and thought to lead to sodium retention by proteolytic activation of the epithelial sodium channel (ENaC). This concept predicts that uPA is an important factor for sodium retention and that inhibition of uPA might be protective in nephrotic syndrome.

Methods: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC. Read More

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http://dx.doi.org/10.1111/apha.13286DOI Listing
April 2019
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The Swedish Neonatal Quality Register (SNQ) - contents, completeness and validity.

Acta Paediatr 2019 Apr 21. Epub 2019 Apr 21.

Swedish Neonatal Quality Register (SNQ).

Aim: To describe the Swedish Neonatal Quality Register (SNQ) and to determine its completeness and agreement with other registers.

Methods: SNQ collects data for infants admitted to neonatal units during the first four postnatal weeks. Completeness and registers' agreement were determined crosslinking SNQ data with Swedish population registers (the Inpatient, Medical Birth and Cause of Death Registers) for a study period of five years. Read More

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http://dx.doi.org/10.1111/apa.14823DOI Listing

The involvement of ventral hippocampal microglial cells, but not cannabinoid CB1 receptors, in morphine-induced analgesia in rats.

Acta Neurol Belg 2019 Apr 20. Epub 2019 Apr 20.

Department of Animal Biology, School of Biology, College of Science, University of Tehran, 4155-6455, Tehran, Iran.

It is well known that glial cells are involved in pain processing. The purpose of the present study was to investigate the possible involvement of the ventral hippocampal (VH) glial cells in morphine-induced analgesia. A tail-flick apparatus was used to measure pain sensitivity in male Wistar rats that were bilaterally cannulated in the VH by stereotaxic surgery. Read More

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http://dx.doi.org/10.1007/s13760-019-01144-0DOI Listing

Selective vulnerability in α-synucleinopathies.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Movement and Clinical Neurosciences, UCL Queen Square Institute of Neurology, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy are neurodegenerative disorders resulting in progressive motor/cognitive deficits among other symptoms. They are characterised by stereotypical brain cell loss accompanied by the formation of proteinaceous aggregations of the protein α-synuclein (α-syn), being, therefore, termed α-synucleinopathies. Although the presence of α-syn inclusions is a common hallmark of these disorders, the exact nature of the deposited protein is specific to each disease. Read More

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http://link.springer.com/10.1007/s00401-019-02010-2
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http://dx.doi.org/10.1007/s00401-019-02010-2DOI Listing
April 2019
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Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer's disease.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Department of Experimental Medical Science, Experimental Neuroinflammation Laboratory, Lund University, 221 84, Lund, Sweden.

Alzheimer's disease (AD) is a progressive neurodegenerative disease in which the formation of extracellular aggregates of amyloid beta (Aβ) peptide, fibrillary tangles of intraneuronal tau and microglial activation are major pathological hallmarks. One of the key molecules involved in microglial activation is galectin-3 (gal3), and we demonstrate here for the first time a key role of gal3 in AD pathology. Gal3 was highly upregulated in the brains of AD patients and 5xFAD (familial Alzheimer's disease) mice and found specifically expressed in microglia associated with Aβ plaques. Read More

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http://dx.doi.org/10.1007/s00401-019-02013-zDOI Listing

Detection of AD-specific four repeat tau with deamidated asparagine residue 279-specific fraction purified from 4R tau polyclonal antibody.

Acta Neuropathol 2019 Apr 20. Epub 2019 Apr 20.

Laboratory of Structural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

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http://dx.doi.org/10.1007/s00401-019-02012-0DOI Listing

The time course of colour congruency effects in picture naming.

Acta Psychol (Amst) 2019 Apr 18;196:96-108. Epub 2019 Apr 18.

Abteilung für Allgemeine Sprachwissenschaft, Institut für Sprache und Information, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen, Nijmegen, Netherlands; Max Planck Institute for Psycholinguistics, Nijmegen, Netherlands. Electronic address:

In our interactions with people and objects in the world around us, as well as in communicating our thoughts, we rely on the use of conceptual knowledge stored in long-term memory. From a frame-theoretic point of view, a concept is represented by a central node and recursive attribute-value structures further specifying the concept. The present study explores whether and how the activation of an attribute within a frame might influence access to the concept's name in language production, focussing on the colour attribute. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00016918183046
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http://dx.doi.org/10.1016/j.actpsy.2019.04.005DOI Listing
April 2019
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Is planning related to dynamic testing outcomes? Investigating the potential for learning of gifted and average-ability children.

Acta Psychol (Amst) 2019 Apr 18;196:87-95. Epub 2019 Apr 18.

Developmental and Educational Psychology, Leiden University, the Netherlands.

This study investigated the potential of dynamic testing of geometric analogical reasoning in differentiating between the potential for learning of gifted and average-ability children (aged 9-10 years old). In doing so, it was analysed whether planning, a higher-order executive function, was related to outcomes of the dynamic test, and to instructional needs during training. Employing a pretest-training-post-test control group design, participants were split into four subgroups: gifted dynamic testing (n = 24), gifted control (n = 26), average-ability dynamic testing (n = 48) and average-ability control (n = 50). Read More

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http://dx.doi.org/10.1016/j.actpsy.2019.04.004DOI Listing

Identifying yeasts using surface enhanced Raman spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 13;218:299-307. Epub 2019 Apr 13.

NanoScience Center, Department of Physics, P.O. Box 35 (YN), FI-40014, University of Jyväskylä, Finland.

The molecular fingerprints of yeasts Saccharomyces cerevisiae, Dekkera bruxellensis, and Wickerhamomyces anomalus (former name Pichia anomala) have been examined using surface-enhanced Raman spectroscopy (SERS) and helium ion microscopy (HIM). The SERS spectra obtained from cell cultures (lysate and non-treated cells) distinguish between these very closely related fungal species. Highly SERS active silver nano-particles suitable for detecting complex biomolecules were fabricated using a simple synthesis route. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13861425193038
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http://dx.doi.org/10.1016/j.saa.2019.04.010DOI Listing
April 2019
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Highly selective silica-based fluorescent nanosensor for ferric ion (Fe) detection in aqueous media.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 2;218:293-298. Epub 2019 Apr 2.

School of Chemistry, College of Science, University of Tehran, Tehran, Iran.

A highly selective fluorescence nanosensor was built based on the functionalized SBA-15 mesoporous silica with Dinitrophenylhydrazine (DNPH). The interaction of fabricated nanosensor was studied with metals ions in aqueous media. Under optimum conditions (time 5 min, pH 7, sensor dose 0. Read More

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http://dx.doi.org/10.1016/j.saa.2019.03.118DOI Listing

Electronic properties and vibrational spectra of (NH)M″(SO)·6HO (M = Ni, Cu) Tutton's salt: DFT and experimental study.

Spectrochim Acta A Mol Biomol Spectrosc 2019 Apr 15;218:281-292. Epub 2019 Apr 15.

National System of Laboratories in Nanotechnologies (SisNANO), Department of Physics, Federal University of Viçosa, Viçosa 36570-000, MG, Brazil.

The complex crystals of the family of the Tutton's salt have been investigated through the numerous experimental and theoretical studies to understand their physical properties and their potential technological applications. In spite of the more than 60 years of research, there are very few studies about the electronic properties of Tutton's salt. In our present work, we have calculated the stability, electronic properties and the first theoretical study of band structure of the three different crystals of the Tutton's salt, ammonium nickel sulfate hexahydrate ((NH)Ni(SO)·6HO), ammonium nickel-copper sulfate hexahydrate ((NH)NiCu(SO)·6HO) and ammonium copper sulfate hexahydrate ((NH)Ni(SO)·6HO) with the help of periodic ab-initio calculations based on density functional theory (DFT). Read More

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http://dx.doi.org/10.1016/j.saa.2019.04.023DOI Listing

Tailoring the CRISPR system to transactivate coagulation gene promoters in normal and mutated contexts.

Biochim Biophys Acta Gene Regul Mech 2019 Apr 18. Epub 2019 Apr 18.

Department of Life Sciences and Biotechnology, University of Ferrara, Italy.

Engineered transcription factors (TF) have expanded our ability to modulate gene expression and hold great promise as bio-therapeutics. The first-generation TF, based on Zinc Fingers or Transcription-Activator-like Effectors (TALE), required complex and time-consuming assembly protocols, and were indeed replaced in recent years by the CRISPR activation (CRISPRa) technology. Here, with coagulation F7/F8 gene promoters as models, we exploited a CRISPRa system based on deactivated (d)Cas9, fused with a transcriptional activator (VPR), which is driven to its target by a single guide (sg)RNA. Read More

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http://dx.doi.org/10.1016/j.bbagrm.2019.04.002DOI Listing

Thermal insulation design bioinspired by microstructure study of penguin feather and polar bear hair.

Acta Biomater 2019 Apr 18. Epub 2019 Apr 18.

International Centre of Electron Microscopy for Materials Science, Faculty of Metals Engineering and Industrial Computer Science, AGH University of Science and Technology, Poland; AGH University of Science and Technology, Al. A. Mickiewicza 30, 30-059 Kraków, Poland. Electronic address:

Nature is an amazing source of inspiration for the design of thermal insulation strategies, which are key for saving energy. In nature, thermal insulation structures, such as penguin feather and polar bear hair, are well developed; enabling the animals' survival in frigid waters. The detailed microscopy investigations conducted in this study, allowed us to perform microstructural analysis of these thermally insulating materials, including statistical measurements of keratin fiber and pore dimensions directly from high resolution Scanning Electron Microscope (SEM) images. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.031DOI Listing

Survivability of rabbit amniotic fluid-derived mesenchymal stem cells post slow-freezing or vitrification.

Acta Histochem 2019 Apr 17. Epub 2019 Apr 17.

Research Institute for Animal Production in Nitra, NAFC, Hlohovecká 2, 951 41 Lužianky, Slovak Republic; Faculty of Biotechnology and Food Science, Slovak University of Agriculture, Tr. A. Hlinku 2, 949 76 Nitra, Slovak Republic; Faculty of Animal Breeding and Biology, University of Technology and Life Sciences, Al. prof. S. Kaliskiego 7, 85 796 Bydgoszcz, Poland.

This work aimed to evaluate the effect of two distinct cryopreservation procedures - conventional slow-freezing and vitrification, on survivability and mesenchymal marker expression stability of rabbit amniotic fluid-derived mesenchymal stem cells (rAF-MSCs). Cells at passage 2 were slowly frozen, using 10% of dimethylsulfoxide, or vitrified, using 40% of ethylene glycol, 0.5 M sucrose and 18% Ficoll 70. Read More

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http://dx.doi.org/10.1016/j.acthis.2019.03.008DOI Listing
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