674,795 results match your criteria Acta Bioquimica Clinica Latinoamericana[Journal]


Impact of an extended postnatal home visiting programme on oral health among children in a disadvantaged area of Stockholm, Sweden.

Acta Paediatr 2020 Jul 4. Epub 2020 Jul 4.

Division of Orthodontics and Pediatric Dentistry, Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.

Aim: To evaluate oral health outcomes and early oral health promotion of children in a Swedish, parental support programme conducted in a collaboration between Child Health Services and Social Services.

Methods: The intervention offered first-time parents six home visits from a paediatric nurse and a parental advisor with Social Services. On the fourth visit (infant age 6-8 months), parents received a toothbrush and fluoride toothpaste from non-dental staff. Read More

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http://dx.doi.org/10.1111/apa.15457DOI Listing

Paediatric emergency department visits fell by more than 70% during the COVID-19 lockdown in Northern Italy.

Acta Paediatr 2020 Jul 4. Epub 2020 Jul 4.

Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

In February 2020 the COVID-19 pandemic flared up across Italy and the first cluster appeared in Southern Lombardy, which is still the most affected area (1). Schools. sports facilities and parks were closed on 1 March, followed by a strict lockdown on 10 March after a significant increase in infections and deaths. Read More

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http://dx.doi.org/10.1111/apa.15458DOI Listing

Correspondence: Actigraphic patterns, impulsivity and mood instability in bipolar disorder, borderline personality disorder and healthy controls.

Acta Psychiatr Scand 2020 Jul 5. Epub 2020 Jul 5.

Psychiatry, McGill University Faculty of Medicine, Montreal, Quebec, Canada.

We would like to commend McGowan and colleagues for their study addressing shared core symptoms of Borderline Personality Disorder (BPD) and Bipolar Disorder (BD) (1). These researchers established significant correlations between dysregulated circadian rest-activity variables (including low interdaily stability and weak amplitude) and symptoms of impulsivity and mood instability among their study participants with BPD. These patterns were neither observed in participants with BD nor in healthy controls. Read More

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http://dx.doi.org/10.1111/acps.13207DOI Listing

β-Cyclodextrin coated porous Pd@Au nanostructures with enhanced peroxidase-like activity for colorimetric and paper-based determination of glucose.

Mikrochim Acta 2020 Jul 4;187(8):425. Epub 2020 Jul 4.

Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei, Anhui, 230009, People's Republic of China.

β-cyclodextrin-functionalized porous Pd@Au nanostructures (β-CD-Pd@Au) with intrinsic and enhanced peroxidase-like activity were successfully synthesized by a two-step method. The synthesized β-CD-Pd@Au can efficiently catalyze the oxidation of various substrates, such as 3,3',5,5'-tetramethylbenzidine (TMB), mixture of 4-amino antipyrine (4-AAP) and 3,5-dichloro-2-hydroxy acid sodium (DHBS) (4-AAP/DHBS), and mixture of 4-AAP and N-Ethyl-N-(3-sulfopropyl)-3-methyl-aniline sodium salt (TOPS) (4-AAP/TOPS), by HO to generate visual blue, purple, and pink color, respectively. The UV-vis absorbance peak of the three β-CD-Pd@Au catalyzed the chromogenic reaction system located at 650 nm, 510 nm, and 550 nm, respectively. Read More

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http://dx.doi.org/10.1007/s00604-020-04410-8DOI Listing

Treatment for secondary deterioration in idiopathic normal pressure hydrocephalus in the later course of the disease: a retrospective analysis.

Acta Neurochir (Wien) 2020 Jul 4. Epub 2020 Jul 4.

Department of Neurosurgery, Klinikum Kassel, Moencheberg Str. 41-43, 34125, Kassel, Germany.

Background: Cerebrospinal fluid (CSF) shunting is a highly effective treatment for idiopathic normal pressure hydrocephalus (iNPH). However, secondary deterioration can occur at a later time. Thus, the current study aimed to evaluate the incidence rate and causes of secondary deterioration. Read More

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http://dx.doi.org/10.1007/s00701-020-04475-7DOI Listing

Correction to: Ultra-thin nanosheet-assembled accordion-like Ni-MOF for hydrazine hydrate amperometric sensing.

Mikrochim Acta 2020 Jul 4;187(8):426. Epub 2020 Jul 4.

School of Chemistry and Chemical Engineering, Institute for Innovative Materials and Energy, Yangzhou University, Yangzhou, Yangzhou, 225002, Jiangsu, People's Republic of China.

The published article is revised due to diagram errors. The authors express their sincere apology, and corrected Figure 2a (XPS), Figure S4 (IR), and Figure S7 (XPS) are given. Read More

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http://dx.doi.org/10.1007/s00604-020-04388-3DOI Listing

A new long-wavelength emission fluorescent probe for imaging biothiols with remarkable Stokes shift.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 27;241:118655. Epub 2020 Jun 27.

College of Pharmacy, Qiqihar Medical University, 333 Bukui Street, Qiqihar, Heilongjiang Province 161006, PR China.

By using BPMOH as the fluorophore and 2, 4-dinitrobenzenesulfonate moiety as the recognition site for thiols, a new long-wavelength emission (645 nm) fluorescent probe BPMSH with large Stokes shift (133 nm) was designed and synthesized. Probe BPMSH exhibited almost no fluorescence emission because of the PET process. When adding thiols, BPMSH could be quickly converted into BPMOH emitting a significant red fluorescence at 645 nm. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118655DOI Listing

Chiral differentiation of l- and d-penicillamine by β-cyclodextrin: Investigated by IRMPD spectroscopy and theoretical simulations.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 26;241:118653. Epub 2020 Jun 26.

State Key Laboratory of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China; Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 30007, China. Electronic address:

The chirality of penicillamine (Peni) results in different clinic applications. Host-guest complex based drug delivery system that differentiates the two enantiomers and provides delayed release is of significance in medication. We hereby used β-CD to encapsulate d- and l-Peni. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118653DOI Listing

Developing a new chemosensor targeting zinc ion based on two types of quinoline platform.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 26;241:118652. Epub 2020 Jun 26.

Department of Fine Chemistry, SNUT (Seoul National Univ. of Sci. and Tech.), Seoul, 01811, Republic of Korea. Electronic address:

A chemosensor DQ (2-(2-(quinolin-2-yl)hydrazinyl)-N-(quinolin-8-yl)acetamide), based on two quinoline moieties, has been synthesized. DQ could detect zinc ion through fluorescence turn-on in aqueous media. Limit of detection was calculated as 0. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118652DOI Listing

A method for isotope exchange kinetics in mineral-water system-an in-situ study on oxygen isotope exchange in NaCO-HO system.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 26;241:118648. Epub 2020 Jun 26.

College of Science, University of Shanghai for Science and Technology, Shanghai 200093, PR China.

The experiments on the exchange reaction rate of the oxygen isotopes in the mineral-water system with initial conditions of 100 °C and 240 MPa, 100 °C and 924 MPa, 118 °C and 170 MPa are taken. The oxygen isotope O exchange reactions between aqueous CO and HO are mainly traced by measuring the Raman peak intensity of oxygen-containing elements (CO) in sodium carbonate solution. The inconsistent trends between the molar fraction and the concentration of COO indicate oxygen isotope exchange between sodium carbonate and heavy water accompanied by dissolution and recrystallization between supersaturated sodium carbonate solution and solid sodium carbonate. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118648DOI Listing

Sodium and manganese salt DNA thin films: An infrared spectroscopy study.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 24;241:118646. Epub 2020 Jun 24.

Department of Physics and Biophysics, School of Medicine, University of Zagreb, 10000 Zagreb, Croatia; Centre of Excellence in Reproductive and Regenerative Medicine, University of Zagreb School of Medicine, 10000 Zagreb, Croatia. Electronic address:

In this work we have investigated influence of divalent Mn ions on the structure of dsDNA utilizing Fourier transform infrared spectroscopy on DNA thin films obtained from sodium and manganese salt DNA (Na-DNA and Mn-DNA) in manganese chloride solutions and manganese salt DNA in pure water. In the range of low Mn content, 0.0067 ≤ r = [manganese]/[phosphate] ≤ 0. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118646DOI Listing

Multi-mode fluorescence sensing detection based on one core-shell structure quantum dots via different types of mechanisms.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;241:118630. Epub 2020 Jun 19.

Research Center for Analytical Science, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Biosensing and Molecular Recognition, College of Chemistry, Nankai University, Tianjin 300071, China.

Multi-target sensing completed with single chemosensor is cost-effective and pretty attractive for the analysis of multiple analytes in single sample. CdTe/CdS QDs show high fluorescence quantum yield as a probe for the sensing purpose, but only single target is often detected. Here we proposed that three kinds of different response mechanisms were realized using CdTe/CdS QDs with the simultaneous sensing of Fe, CrO, and IO as model. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118630DOI Listing

In vitro temperature sensing with up-conversion NaYF:Yb/Tm-based nanocomposites: Peculiarities and pitfalls.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;241:118627. Epub 2020 Jun 19.

Faculty of Physics, Lomonosov Moscow State University, Moscow, Russia.

The luminescence intensity ratio method, exploiting the temperature-dependent luminescence of the thermally coupled energy levels, is regarded as a very promising approach for optical temperature measurement at the cellular level. In this study, it was found that bare NaYF:Yb/Tm nanoparticles cannot be used as a cellular thermosensor in principle because of their tendency to aggregate, which significantly affects the luminescent properties of the complex, introducing uncertainty in the intensity ratio measurement. NaYF:Yb/Tm up-conversion nanoparticles, coated with polyethylene glycol (PEG) and carboxyl groups (COOH), on the other hand, proved to be promising candidates for the role of thermosensors. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118627DOI Listing

Corrigendum to "UV-visible and fluorescence spectroscopic assessment of meso-tetrakis-(4-halophenyl) porphyrin; HTXPP (X = F, Cl, Br, I) in THF and THF-water system: Effect of pH and aggregation behaviour" [Spectrochim. Acta A: Mol. Biomol. Spectrosc. 240 (2020) 118570].

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jul 2;241:118656. Epub 2020 Jul 2.

Department of Chemistry, National Institute of Technology Srinagar, Hazratbal, Srinagar 190006, J & K, India. Electronic address:

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http://dx.doi.org/10.1016/j.saa.2020.118656DOI Listing

Challenges and opportunities for top-down modulation research in cognitive psychology.

Acta Psychol (Amst) 2020 Jul 2;209:103118. Epub 2020 Jul 2.

Wales Institute for Cognitive Neuroscience, School of Psychology, Bangor University, Bangor, Gwynedd, Wales LL57 2AS, United Kingdom.

Studying social modulation of cognitive processes holds much promise for illuminating how, where, when and why social factors influence how we perceive and act in the world, as well as providing insight into the underlying cognitive mechanisms. This is no small objective; it reflects an ambitious programme of research. At present, based on the modal theoretical and methodological approach, we suggest that several challenges exist to achieving such lofty aims. Read More

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http://dx.doi.org/10.1016/j.actpsy.2020.103118DOI Listing

Antioxidant-mediated control of degradation and drug release from surface-eroding poly(ethylene carbonate).

Acta Biomater 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutics and Biopharmacy, Philipps-Universität, Marburg, Germany. Electronic address:

Surface-eroding polymers are of significant interest for various applications in the field of controlled drug delivery. Poly(ethylene carbonate), as an example, offers little control over the rate of degradation and, thus, drug release, which usually conflicts with the requirements for long-acting medications. Here, we challenged an option to decelerate the degradation of poly(ethylene carbonate) in vitro and in vivo. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.041DOI Listing

Non-viral Gene Delivery of HIF-1α Promotes Angiogenesis in Human Adipose-Derived Stem Cells.

Acta Biomater 2020 Jul 2. Epub 2020 Jul 2.

Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Translational Tissue Engineering Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Institute for Nanobiotechnology, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA; Department of Oncology and Bloomberg∼Kimmel Immunotherapy Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA; Department of Ophthalmology Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA. Electronic address:

Stable and mature vascular formation is a current challenge in engineering functional tissues. Transient, non-viral gene delivery presents a unique platform for delivering genetic information to cells for tissue engineering purposes and to restore blood flow to ischemic tissue. The formation of new blood vessels can be induced by upregulation of hypoxia-inducible factor-1α (HIF-1), among other factors. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.042DOI Listing

A pericellular hyaluronan matrix is required for the morphological maturation of cortical neurons.

Biochim Biophys Acta Gen Subj 2020 Jul 2:129679. Epub 2020 Jul 2.

Graduate School of Bioagricultural Sciences, Nagoya University, Furocho, Chikusa-Ku, Nagoya 464-8601, Japan; Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan. Electronic address:

Background: Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is involved in many cellular functions. In the adult brain, HA forms macromolecular aggregates around synapses and plays important roles in neural plasticity. In contrast to the well-characterized function of HA in the adult brain, its roles in the developing brain remain largely unknown. Read More

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http://dx.doi.org/10.1016/j.bbagen.2020.129679DOI Listing

Pigments test strips: a rapid companion test to exclude sub-arachnoid haemorrhage.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

Biochemistry Department, Bordeaux University Hospital, Place Amélie Raba Léon 33076 Bordeaux France; Université de Bordeaux, France.

Objectives: Subarachnoid haemorrhage (SAH) is characterised by 25% of mortality or induces long-term care. It needs immediate diagnosis with computed tomography (CT) scan. For the inconclusive CT scans, the detection of haem pigments can be performed in the cerebrospinal fluid (CSF). Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.052DOI Listing

Critical evaluation of equations for serum osmolality: proposals for effective clinical utility.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemical Pathology, Faculty of Health Sciences, University of Pretoria and National Health Laboratory Service Tshwane Academic Division, Pretoria, South Africa; Division of Chemical Pathology, Faculty of Health Sciences, University of Cape Town. Electronic address:

Background: Many studies have assessed the predictive accuracy of serum osmolality equations. Different approaches for selecting a usable equation were compared using thirty published equations and patient data from a regional hospital laboratory.

Methods: Laboratory records were extracted with same-sample results for measured serum osmolality, sodium, potassium, urea and glucose analysed in a regional hospital laboratory between 1/1/2017-31/12/2018. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.043DOI Listing

Pyroptosis: a pro-inflammatory type of cell death in cardiovascular disease.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

Department of Cardiovascular Medicine, Key Laboratory of Heart Failure Prevention & Treatment of Hengyang, the Second Affiliated Hospital of University of South China, 421001, Hunan Province, China. Electronic address:

Pyroptosis is a pro-inflammatory type of regulated cell death (RCD) characterized by gasdermin D (GSDMD)-mediated membrane pore formation, cell swelling and rapid lysis, followed by the massive release of pro-inflammatory mediators such as interleukin-1β and interleukin-18. There are two main pathways of pyroptosis: the caspase-1-mediated canonical pathway and the caspase-4/5/11-mediated noncanonical pathway. However, the caspase-3-gasdermin E (GSDME) pathway and caspase-8-GSDMD pathway also induce pyroptosis. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.044DOI Listing

Quantitative determination of agglutination based on the automatic hematology analyzer and the clinical significance of the erythrocyte-specific antibody.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

College of Medical Laboratory, Dalian Medical University, Dalian, China. Electronic address:

Objective: The objective of this work was to explore the similarities and differences between the automatic hematology analyzer method and the traditional slide method in the detection of red blood cell (RBC) agglutination, and demonstrate that the automatic hematology analyzer is more intuitive and reliable for the detection of RBC agglutination. A further objective was to establish a new method to facilitate new ideas for clinical research.

Methods: Type A serum was selected and diluted 1:2, 1:4, 1:8, 1:16, and 1:32, to react with the type B cells and the normal saline group was used as the control group. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.042DOI Listing

Advances in lipidomics.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemistry, University of Helsinki, P.O. Box 55, FI-00014 University of Helsinki (FI-00560 Helsinki), Finland. Electronic address:

The present article examines recently published literature on lipids, mainly focusing on research involving glycero-, glycerophospho- and sphingo-lipids. The primary aim is identification of distinct profiles in biologic lipidomic systems by ultra-high-performance liquid chromatography (UHPLC) coupled with mass spectrometry (MS, tandem MS) with multivariate data analysis. This review specifically targets lipid biomarkers and disease pathway mechanisms in humans and artificial targets. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.049DOI Listing

Liquid biopsy in ovarian cancer.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

School of Biotechnology, National Institute of Technology, Calicut-673601, Kerala, India. Electronic address:

Ovarian cancer is typically diagnosed at an advanced stage and poses a significant challenge to treatment and recovery. Relapsed ovarian cancer and chemoresistance of ovarian tumor cells are other clinical challenges. Liquid biopsy is an essential non-invasive diagnostic test that evaluates circulating tumor cells and tumor DNA, as well as other blood markers that may be useful in guiding precision medicine. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.047DOI Listing

A single-center observational study on the expression of circulating interleukin-20 levels and predicting outcomes in human chronic heart failure: a 2-year follow-up cohort study.

Clin Chim Acta 2020 Jul 2. Epub 2020 Jul 2.

Xishui County People's Hospital affiliated to Hubei University of Science and Technology, Hubei 530021, China. Electronic address:

Background: Interleukin-20 (IL-20) is closely related to cardiovascular diseases such as atherosclerosis. The relevance of IL-20 expression in human chronic heart failure (CHF) remains unknown. Thus, we investigated the level of circulating IL-20 in CHF patients and observed its correlation with CHF outcomes. Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.048DOI Listing

Identification of the electron donor to flavodiiron proteins in Synechocystis sp. PCC 6803 by in vivo spectroscopy.

Biochim Biophys Acta Bioenerg 2020 Jul 2:148256. Epub 2020 Jul 2.

Department of Biological and Environmental Sciences, Faculty of Agriculture, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.

Flavodiiron proteins (FDPs) of photosynthetic organisms play a photoprotective role by reducing oxygen to water and thus avoiding the accumulation of excess electrons on the photosystem I (PSI) acceptor side under stress conditions. In Synechocystis sp. PCC 6803 grown under high CO, both FDPs Flv1 and Flv3 are indispensable for oxygen reduction. Read More

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http://dx.doi.org/10.1016/j.bbabio.2020.148256DOI Listing

Effects of moderate aerobic exercise on thoracic aortic remodeling of female LDL-receptor knockout ovariectomized mice.

Acta Histochem 2020 Jul 20;122(5):151575. Epub 2020 Jun 20.

Laboratory of Morphological and Immunohistochemical Studies, Department of Physical Education, São Judas Tadeu University, São Paulo, SP, Brazil; Dante Pazzanese Institute of Cardiology, São Paulo, SP, Brazil.

Menopause is a major factor involved in dyslipidemia increasing the risk of atherosclerosis which may be reversed by a routine of aerobic physical activity. Thus, this study aimed to analyze the effects of aerobic training on the thoracic aorta of female LDL-receptor knockout mice submitted to estrogen deprivation. Fifteen genetically modified female mice, knockout for the low-density lipoprotein receptor (LDL-Knockout group) were used as experimental groups and fifteen wild female mice (C57BL/6 J) were used as control groups. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151575DOI Listing

Remodeling of the soleus muscle of ovariectomized old female rats submitted to resistance training and different diet intake.

Acta Histochem 2020 Jul 28;122(5):151570. Epub 2020 May 28.

Laboratory of Morphological and Immunohistochemical Studies, Department of Physical Education, São Judas Tadeu University, São Paulo, SP, Brazil.

Sarcopenia is a common condition that is associated mainly with hormonal factors, nutritional status, physical activity, leading to a lower quality of life. Thus, this study aimed to evaluate the effects of diets with vegetable or animal proteins (AP) associated with resistance training on the structure of the soleus muscle in aged Wistar rats. The histochemical technique was used for the typing of muscle fibers, the cross-sectional area of myocytes, and volume densities of myocytes and interstitium. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151570DOI Listing

Lappaconitine sulfate induces apoptosis and G0/G1 phase cell cycle arrest by PI3K/AKT signaling pathway in human non-small cell lung cancer A549 cells.

Acta Histochem 2020 Jul 6;122(5):151557. Epub 2020 Jun 6.

School of Pharmacy, Lanzhou University, 730000, Lanzhou, Gansu, China.

Lappaconitine sulfate (LS) has good solubility and bioavailability. We have previously studied the anti-proliferative activity of LS on colon cancer HT-29 cell, but its anti-proliferative activity and molecular mechanism on human non-small cell lung cancer A549 cells are still unclear. This study was to investigate the effects of LS on proliferation, cell cycle and apoptosis in human non-small cell lung cancer A549 cells, and its possible molecular mechanisms. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151557DOI Listing

Identification of aspartame-induced haematopoietic and lymphoid tumours in rats after lifetime treatment.

Acta Histochem 2020 Jul 20;122(5):151548. Epub 2020 May 20.

Cesare Maltoni Cancer Research Center, Ramazzini Institute, via Saliceto 3, 40010 Bentivoglio, Bologna, Italy. Electronic address:

Lymphomas and leukaemias involving the lung have in some cases been hard to distinguish from respiratory tract infection in Sprague-Dawley (SD) rats from long-term bioassays. In order to differentiate between tumours and immune cell infiltrates, updated pathological criteria and nomenclature were used and immunohistochemistry (IHC) was applied to haematopoietic and lymphoid tissue tumours (HLTs) in the original prenatal long-term Aspartame (APM) study performed by the Ramazzini Institute (RI). All 78 cases of HLTs from treated and control groups were re-examined based on light microscopic morphological characteristics and subjected to a panel of IHC markers including Ki67, CD3, PAX5, CD20, CD68, TdT, CD45, CD14 and CD33. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151548DOI Listing

Thyroidectomy induces thyroglobulin formation by parotid salivary glands in rats.

Acta Histochem 2020 Jul 26;122(5):151568. Epub 2020 May 26.

Oral Biology Department, Faculty of Dentistry, Tanta University, Tanta, Egypt.

Structural changes in parotid gland (PG) were previously reported following ablation of thyroid gland. However, the functional alterations (especially for proteins) have not been elucidated yet. Herein, we investigated the effect of rat thyroidectomy on PG structure and protein content and studied the ability of thyroxin-supplementation to alleviate the associated structural and functional changes. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151568DOI Listing

Quercetin mitigates monosodium glutamate-induced excitotoxicity of the spinal cord motoneurons in aged rats via p38 MAPK inhibition.

Acta Histochem 2020 Jul 20;122(5):151554. Epub 2020 May 20.

Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt. Electronic address:

Various studies reported the possibility of deterioration of blood-brain barrier (BBB) integrity owing to the aging process. The current work was performed to investigate the ability of Monosodium glutamate (MSG) to cross BBB in aged rats, the damage affecting the anterior horn cells of the spinal cord due to excitotoxicity, and the mechanisms by which quercetin (Que) administration might suppress such damage. Forty male rats aged 18 months were assigned equally to 4 groups: control group, Que group (received Que, 20 mg/kg/d intraperitonealy for 10 days), MSG group (received MSG, 4. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151554DOI Listing

Protective action of melatonin on diabetic rat testis at cellular, hormonal and immunohistochemical levels.

Acta Histochem 2020 Jul 26;122(5):151559. Epub 2020 May 26.

Federal Rural University of Pernambuco, Department of Morphology and Animal Physiology, Recife CEP 52171-900, Brazil.

The aim of the present study was to analyze the effects of melatonin treatment on diabetic rat testes. Fifty albino rats were divided into the following groups: CG: control group; GD: placebo-induced and placebo-treated mice; GDI: insulin-induced and post-confirmation diabetes-induced rats; GDM: diabetes-induced and melatonin-treated post-confirmation mice and GDMS: diabetes-induced and melatonin-treated mice simultaneously. Melatonin was administered at a dose of 10 mg/kg in drinking water every day for 20 days at night. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151559DOI Listing

Differentiation of NSC-34 cells is characterized by expression of NGF receptor p75, glutaminase and NCAM L1, activation of mitochondria, and sensitivity to fatty acid intervention.

Acta Histochem 2020 Jul 15;122(5):151574. Epub 2020 Jun 15.

Dept. of Trauma Surgery, Medical Faculty, University of Magdeburg, 39120 Magdeburg, Germany.

Motor neuronal damage due to diseases, traumatic insults or de-afferentation of the spinal cord is often incurable because of poor intrinsic regenerative capacity. Hence, medical basic research has to provide a better understanding of development-/regeneration-related cellular processes as only way to develop new and successful therapeutic strategies. Here, we investigated the neuronal differentiation of the NSC-34 hybrid cell line, which is an accepted model for spinal cord motor neurons. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151574DOI Listing

Autologously transplanted dermal fibroblasts improved diabetic wound in rat model.

Acta Histochem 2020 Jul 20;122(5):151552. Epub 2020 May 20.

İstanbul University, İstanbul Medicine Faculty, Histology and Embryology Department, Fatih, İstanbul, Turkey.

Healing of diabetic wounds are delayed due to late initiation and prolongation of the inflammatory phase, and inadequate growth factor synthesis, which may lead to chronic ulcers that may cause limb amputation, besides making the patients vulnerable to infections. In recent years, it has been extensively discussed whether different cell types transplanted to diabetic wound models accelerate wound healing. In this study, the effect of dermis-derived cells on Streptozotocin (STZ) induced experimental diabetic Sprague-Dawley rats were investigated. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151552DOI Listing

MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9.

Acta Histochem 2020 Jul 16;122(5):151571. Epub 2020 Jun 16.

Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, People's Republic of China. Electronic address:

Emerging evidence has unraveled the important implications of microRNAs (miRNAs/miRs) in intracerebral hemorrhage (ICH). The aim of the present study was to assess the possible regulatory role of miR-26a-5p in ICH both in vivo and in vitro. ICH model of rats was constructed using stereotactic injection of VII collagenase, and ICH condition of PC-12 cells was stimulated by hemin. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151571DOI Listing

Effects of adipose- derived stromal vascular fraction on asherman syndrome model.

Acta Histochem 2020 Jul 20;122(5):151556. Epub 2020 May 20.

Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; Endometrium and Endometriosis Research Centre, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Asherman's syndrome (AS) is an endometrial damage that results in infertility in women. Although stem cell therapy has been introduced as a potential treatment for this syndrome, its use in clinical settings remains challenging because of the likelihood of contamination and cell differentiation. Herein, we investigated the effects of adipose-derived stromal vascular fraction (SVF) transplantation on proliferation and angiogenesis in the endometrium in an AS model. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151556DOI Listing

Three-dimensional co-culture of human spermatogonial stem cells with Sertoli cells in soft agar culture system supplemented by growth factors and Laminin.

Acta Histochem 2020 Jul 13;122(5):151572. Epub 2020 Jun 13.

Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Application of a three-dimensional (3D) culture system for in vitro proliferation and differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the investigation of the spermatogenesis process and the management of male infertility particularly in prepubertal cancer patients. The main purpose of this study was to investigate the proliferation of human SSCs co-cultured with Sertoli cells in soft agar culture system (SACS) supplemented by Laminin and growth factors. Testicular cells were isolated from testes of brain-dead patients and cultured in two-dimensional (2D) culture system for 3 weeks. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151572DOI Listing

Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats.

Acta Histochem 2020 Jul 20;122(5):151558. Epub 2020 May 20.

Laboratory of Neurobiology, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wojska Polskiego 71C, 60-625 Poznan, Poland. Electronic address:

Obesity, which reaches an epidemic, is characterized by alterations in metabolic and hormonal profiles. Moreover, uncontrolled obesity may lead to development of diabetes type 2, which accounts for about 90% of all diabetic cases. In obesity, besides changes in metabolism, numerous co-morbidities are reported, e. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151558DOI Listing

Ectopic subcutaneous transplantation of fetal rat urogenital sinus and seminal vesicle promotes the organ growth and formation.

Acta Histochem 2020 Jul 10;122(5):151569. Epub 2020 Jun 10.

Division of Microscopic and Developmental Anatomy, Department of Anatomy, Kurume University School of Medicine, Kurume, Fukuoka, Japan.

Purpose: The fate of subcutaneously transplanted urogenital sinus (UGS) and seminal vesicle (SV) was investigated in the present study.

Materials And Methods: Fetal UGS and SV extracted from 20-embryonic-day-old male normal and GFP transgenic rats were subcutaneously transplanted into 7-week-old male immunologically inhibited rats. The transplants were then examined at 2, 4, 8, and 16 weeks after transplantation. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151569DOI Listing

Structural and chemical changes in glial cells in the rat neocortex induced by constant occlusion of the middle cerebral artery.

Acta Histochem 2020 Jul 13;122(5):151573. Epub 2020 Jun 13.

Laboratory of Physiology, A.V. Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok 690041, Russia. Electronic address:

Stroke-induced changes in neuroglia determine the basic conditions for the survival and damage of neurons in the ischemic core. Here, we studied the immunolocalization of glial cell line-derived neurotrophic factor (GDNF), glial fibrillary acidic protein (GFAP), ionized calcium-binding adaptor molecule 1 (Iba-1), and S-100β in the rat parietal cortex after constant occlusion of the middle cerebral artery. These cytoplasmic proteins are specific for different glial cell types. Read More

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http://dx.doi.org/10.1016/j.acthis.2020.151573DOI Listing

Attentional flexibility and prioritization improves long-term memory.

Acta Psychol (Amst) 2020 Jul 1;208:103104. Epub 2020 Jul 1.

Department of Psychology, College of Staten Island, City University of New York, Staten Island, NY, USA.

Recent evidence suggests the focus of attention (FoA) is a flexible resource within working memory (WM) used to temporarily maintain some information in a highly accessible state. This flexibility comes at the expense of other representations, demonstrating a resource trade-off in WM maintenance. The present experiments evaluate how flexibility within the FoA impacts long-term memory (LTM) for semantically meaningful information. Read More

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http://dx.doi.org/10.1016/j.actpsy.2020.103104DOI Listing

The "discovery" of lipid droplets: A brief history of organelles hidden in plain sight.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jul 1:158762. Epub 2020 Jul 1.

Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States of America. Electronic address:

Mammalian lipid droplets (LDs), first described as early as the 1880s, were virtually ignored for more than 100 years. Between 1991 and the early 2000s, however, a series of discoveries and conceptual breakthroughs led to a resurgent interest in obesity as a disease, in the metabolism of intracellular triacylglycerol (TAG), and in the physical locations of LDs as cellular structures with their associated proteins. Insights included the recognition that obesity underlies major chronic diseases, that appetite is hormonally controlled, that hepatic steatosis is not a benign finding, and that diabetes might fundamentally be a disorder of lipid metabolism. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158762DOI Listing

Exosomes as a next-generation drug delivery system: An update on drug loading approaches, characterization, and clinical application challenges.

Acta Biomater 2020 Jul 1. Epub 2020 Jul 1.

Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Exosomes are small nanoparticles secreted by almost all cells and have a well-known role in intercellular communication. They are found in different body fluids and can also be isolated from cell culture media. They contain a natural cargo including various protein and nucleic acid molecules originated from their donor cells. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.036DOI Listing

Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice.

Acta Biomater 2020 Jul 1. Epub 2020 Jul 1.

i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Rua Alfredo Allen, 208, 4200-135 Porto, Portugal. Electronic address:

Persistent Helicobacter pylori (H. pylori) infection is related to 90% of gastric cancers. With bacterial resistance rising and treatment inefficiency affecting 15% of the patients, alternative treatments urge. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.035DOI Listing

Advancing bioinks for 3D bioprinting using reactive fillers: A review.

Acta Biomater 2020 Jul 1. Epub 2020 Jul 1.

Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91058 Erlangen, Germany. Electronic address:

The growing demand for personalized implants and tissue scaffolds requires advanced biomaterials and processing strategies for the fabrication of three-dimensional (3D) structures mimicking the complexity of the extracellular matrix. During the last years, biofabrication approaches like 3D printing of cell laden (soft) hydrogels have been gaining increasing attention to design such 3D functional environments which resemble natural tissues (and organs). However, most of these polymeric hydrogels show poor stability and low printing fidelity and hence various approaches in terms of multi-material mixtures are being developed to enhance pre- and post-printing features as well as cytocompatibility and post-printing cellular development. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.040DOI Listing

Recent Progress and Strategies to Develop Antimicrobial Contact Lenses and Lens Cases for Different Types of Microbial Keratitis.

Acta Biomater 2020 Jul 1. Epub 2020 Jul 1.

Center of Super-Diamond and Advanced Films (COSDAF), Department of Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong. Electronic address:

Although contact lenses are widely used for vision correction, they are also the primary cause of a number of ocular diseases such as microbial keratitis (MK), etc. and inflammatory events such as infiltrative keratitis (IK), contact lens acute red eye (CLARE), contact lens-induced peripheral ulcer (CLPU), etc. These diseases and infiltrative events often result from microbial contamination of lens care solutions and lens cases that can be exacerbated by unsanitary lens care and extended lens wear. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.06.039DOI Listing

Acrylamide-hemoglobin adduct: A spectroscopic study.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 25;241:118644. Epub 2020 Jun 25.

Microbial Stress Lab, UCIBIO, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal. Electronic address:

Acrylamide is a neurotoxic and carcinogenic organic compound that is able to bind to several biomolecules and form adducts, through nucleophilic addition and in vivo by the Maillard Reaction, interfering with the biological functions of these molecules. Hemoglobin is one of the most abundant intracellular blood proteins, and thus it is of high interest to understand whether the binding of acrylamide can alter its properties. The interaction of acrylamide with hemoglobin was assessed in a 20:1 ratio, and after a 72 h-incubation period, a decrease of ca. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118644DOI Listing

A Raman spectroscopy analysis method for rapidly determining saccharides and its application to monitoring the extraction process of Wenxin granule manufacturing procedure.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 15;241:118603. Epub 2020 Jun 15.

Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, PR China. Electronic address:

Saccharides are the major constituents of many herbs, and they are often utilized as quality indicators of many botanical drugs, such as Chinese medicines. A method for the rapid determination of saccharides in the in-process extract solutions is beneficial for process monitoring and ensuring consistency in the quality of the end-products during the manufacturing of Chinese medicines. In this work, a method based on Raman spectroscopy and a competitive adaptive reweighted sampling-partial least squares (CARS-PLS) model was established for the rapid quantification of saccharides. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118603DOI Listing

Water retention capabilities of collagen, gelatin and peptide as studied by IR/QCM/RH system.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 19;241:118619. Epub 2020 Jun 19.

Department of Earth and Space Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka, Osaka 560-0043, Japan; Faculty of Environmental and Urban Engineering, Kansai University, Yamate-cho 3-3-35, Suita-shi, Osaka 564-8680, Japan; Research Institute for Natural Environment, Science and Technology (RINEST), Tarumi-cho 3-6-32 Maison Esaka 1F, Suita-shi, Osaka 564-0062, Japan. Electronic address:

In this study, water retention properties of triple helix collagen, gelatin (separated single chains) and peptide (broken peptide fragments) were studied by using IR micro-spectroscopy equipped with a relative humidity (RH) control system and quartz crystal microbalance (QCM). Adsorbed water ratios (wt%) are found to be in the order of collagen, gelatin and peptide (at about RH = 60%, 22 wt% for collagen, 14 wt% for gelatin and 9 wt% for peptide). Free water molecules with longer H bonds are the major adsorbed water species for collagen, gelatin and peptide. Read More

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http://dx.doi.org/10.1016/j.saa.2020.118619DOI Listing
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