690,544 results match your criteria Acta Bioquimica Clinica Latinoamericana[Journal]


Generation of a nanobody-alkaline phosphatase fusion and its application in an enzyme cascade-amplified immunoassay for colorimetric detection of alpha fetoprotein in human serum.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jun 17;262:120088. Epub 2021 Jun 17.

College of Food Science and Engineering, Hainan University, Haikou 570228, China. Electronic address:

Sensitive detection of liver disease biomarkers can facilitate the diagnosis of primary hepatoma and other benign liver diseases, and the alpha fetoprotein (AFP) was selected as the model macromolecule in this work. Herein an enzyme cascade-amplified immunoassay (ECAIA) based on the nanobody-alkaline phosphatase fusion (Nb-ALP) and MnO nanoflakes was developed for detecting AFP. The bifunctional biological macromolecule Nb-ALP serves as the detection antibody and the reporter molecule. Read More

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Evaluation of Triclosan-induced reproductive impairments in the accessory reproductive organs and sperm indices in the mice.

Acta Histochem 2021 Jun 21;123(5):151744. Epub 2021 Jun 21.

Zoology Section, MMV, Banaras Hindu University, Varanasi, 221005, India. Electronic address:

Highly effective antimicrobial properties of triclosan (TCS) make its use as a widely used preservative in different types of consumer products. TCS is reported as an emerging endocrine disruptor causing reproductive impairments in the males as well as in the females. The present study describes the adverse effects of various doses of TCS (40, 80, 160 and 320 mg/kg BW/day, for 42 consecutive days) on the weights and histopathology of the epididymis and seminal vesicle, sperm indices (motility, viability, count and morphology), concentrations of epididymal sialic acid and seminal vesicular fructose, along with TCS accumulated in these accessory reproductive organs of the laboratory mouse. Read More

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RAGE and αVβ3-integrin are essential for suPAR signaling in podocytes.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 21:166186. Epub 2021 Jun 21.

Department of Biology and Biochemistry, University of Houston, Houston, TX, USA 77204; Department of Biomedical Sciences, University of Houston College of Medicine, Houston, TX, USA, 77204. Electronic address:

The soluble urokinase plasminogen activator receptor (suPAR) has been implicated in the pathogenesis of kidney diseases including primary and recurrent focal and segmental glomerulosclerosis (FSGS), diabetic nephropathy, and acute kidney injuries (AKI). Elevated serum suPAR concentration is a negative prognostic indicator in multiple critical clinical conditions. This study has examined the initial transduction steps used by suPAR in cultured mouse podocytes. Read More

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PICT1 is critical for regulating the Rps27a-Mdm2-p53 pathway by microtubule polymerization inhibitor against cervical cancer.

Biochim Biophys Acta Mol Cell Res 2021 Jun 21:119084. Epub 2021 Jun 21.

Department of Gynecology, Wuhan Fifth Hospital, 122 Xian Zheng Street, Wuhan, Hubei 430050, P. R. China. Electronic address:

In our previous study, it showed that P-3F, a podophyllotoxin derivative, causes the increased level of p53 expression by enhancing p53 stability, resulting from blockage of the Mdm2-p53 feedback loop via nucleolus-to-nucleoplasm translocation of Rps27a in human cervical cancer HeLa cell line. However, the mechanism of regulating Rps27a localization remains to be studied. In the current study, it has been demonstrated that the level of protein interacting with carboxyl terminus 1 (PICT1), originally identified as a tumor suppressor, was decreased in a concentration-dependent manner in response to P-3F, leading to inhibition of human cervical cancer cell lines proliferation. Read More

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Lipids, membranes, colloids and cells: A long view.

Biochim Biophys Acta Biomembr 2021 Jun 21:183684. Epub 2021 Jun 21.

MEMPHYS - International and Interdisciplinary research network, Denmark.

This paper revisits long-standing ideas about biological membranes in the context of an equally long-standing, but hitherto largely unappreciated, perspective of the cell based on concepts derived from the physics and chemistry of colloids. Specifically, we discuss important biophysical aspects of lipid supramolecular structure to understand how the intracellular milieu may constrain lipid self-assembly. To this end we will develop four lines of thought: first, we will look at the historical development of the current view of cellular structure and physiology, considering also the plurality of approaches that influenced its formative period. Read More

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Cognitive Performance in Older-Age Bipolar Disorder: investigating psychiatric characteristics, cardiovascular burden, and psychotropic medication.

Acta Psychiatr Scand 2021 Jun 24. Epub 2021 Jun 24.

Amsterdam UMC, Vrije Universiteit, Psychiatry, Amsterdam Public Health Research Institute, de Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Objective: This study aimed to explore a large range of candidate determinants of cognitive performance in older-age bipolar disorder (OABD).

Methods: A cross-sectional study was performed in 172 BD patients aged ≥50 years. Demographics, psychiatric characteristics, and psychotropic medication use were collected using self-report questionnaires and structured interviews. Read More

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Impact of tobacco smoking on pulmonary and kidney function after successful kidney transplantation - A single-centre pilot study.

Acta Biochim Pol 2021 Jun 24. Epub 2021 Jun 24.

Department of Nephrology, Transplantology and Internal Diseases, Medical University of Gdansk, Gdansk, Poland.

The all consequences of tobacco smoking on the lungs and kidney function in kidney transplant recipients are unknown. We investigate the impact of tobacco smoking on lung and kidney functions in kidney transplantation recipients.

Methods: Finally, 55 patients were evaluated after kidney transplantation (age 50. Read More

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The combined use of endometrial ablation or resection and levonorgestrel-releasing intrauterine system in women with heavy menstrual bleeding: A systematic review.

Acta Obstet Gynecol Scand 2021 Jun 24. Epub 2021 Jun 24.

Department of Obstetrics and Gynecology, Máxima Medical Center, Veldhoven, The Netherlands.

Introduction: Despite the fact that endometrial ablation/resection is a very successful treatment for women with heavy menstrual bleeding, re-intervention with additional surgery is needed in 12-25% of the cases. Introducing a levonorgestrel-intrauterine system (LNG-IUS) immediately after ablation could preserve the integrity of the uterine cavity and suppress the regenerated or non-ablated endometrial tissue. Therefore, this combined treatment can perhaps lower the re-intervention rate. Read More

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Multifunctional lanthanide metal-organic framework based ratiometric fluorescence visual detection platform for alkaline phosphatase activity.

Mikrochim Acta 2021 Jun 24;188(7):236. Epub 2021 Jun 24.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Ministry of Education), and Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, China.

A turn-on/off ratiometric fluorescence detection platform based on multifunctional lanthanide metal-organic framework (Ln-MOF) and an enzymatic cascade reaction is proposed for alkaline phosphatase (ALP) activity assay. L-phosphotyrosine is hydrolyzed to levodopa (L-dopa) by two steps of enzymatic reaction. L-dopa further reacts with naphthoresorcinol to produce carboxyazamonardine with strong emission at 490 nm. Read More

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Strawberry milkshake-like idiopathic pericardial effusion.

Acta Cardiol 2021 Jun 24:1-2. Epub 2021 Jun 24.

Department of Internal Medicine 2, Division of Cardiology, Paracelsus Medical University Salzburg, Salzburg, Austria.

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Cat at home? Cat scratch disease with atypical presentations and aggressive radiological findings mimicking sarcoma, a potential diagnostic pitfall.

Acta Orthop 2021 Jun 24:1-7. Epub 2021 Jun 24.

Department of Orthopedics and Trauma, Medical University of Graz, Graz.

Background and purpose - Cat scratch disease (CSD) is a self-limiting disease caused by It is characterized by granulomatous infection, most frequently involving lymph nodes. However, it can present with atypical symptoms including musculoskeletal manifestations, posing a diagnostic challenge. We describe the prevalence and demographics of CSD cases referred to a sarcoma center, and describe the radiological, histological, and molecular findings. Read More

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Surgeons' behaviors and beliefs regarding placebo effects in surgery.

Acta Orthop 2021 Jun 24:1-6. Epub 2021 Jun 24.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Background and purpose - Emerging evidence from sham-controlled trials suggest that surgical treatment entails substantial non-specific treatment effects in addition to specific surgical effects. Yet, information on surgeons' actual behaviors and beliefs regarding non-specific treatment and placebo effects is scarce. We determined surgeons' clinical behaviors and attitudes regarding placebo effects. Read More

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Epizootiology and Molecular Identification of Trypanosome Species in Livestock Ruminants in the Gambia.

Acta Parasitol 2021 Jun 23. Epub 2021 Jun 23.

Department of Biochemistry, Ahmadu Bello University, P.M.B 1044, Zaria, Kaduna State, Nigeria.

Introduction: African Animal Trypanosomiasis (AAT) or nagana in animals, is caused by the blood-borne parasitic protozoa called trypanosomes, and is potentially fatal. It is estimated that Africa loses $4‒5 billion annually due to the death of livestock to nagana in the tsetse belt.

Purpose: Although The Gambia lies within this belt, there is scanty data regarding the epizootiology of nagana in The Gambia. Read More

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Heteropore covalent organic framework-based composite membrane prepared by in situ growth on non-woven fabric for sample pretreatment of food non-targeted analysis.

Mikrochim Acta 2021 Jun 23;188(7):235. Epub 2021 Jun 23.

Tianjin Key Laboratory of Biosensing and Molecular Recognition, Key Laboratory of Functional Polymer Materials, Ministry of Education, Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China.

A heteropore covalent organic framework (COF)-based composite membrane material was prepared and proved to have a satisfactory effect on the pretreatment of vegetable samples. The composite membrane was fabricated by in situ growth of a dual-pore COF on the surface of polydopamine (PDA)-aminated non-woven (NW) fabric. Due to the difference in the strength of the interaction between the phytochromes/COF and the pesticides/COF, the removal of phytochromes and the recovery of pesticides can be achieved by adjusting the composition of the solution. Read More

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How I do it: parietal trans-sulcal para-fascicular approach to lateral thalamic/internal capsule cavernous malformation.

Acta Neurochir (Wien) 2021 Jun 24. Epub 2021 Jun 24.

Department of Neurosurgery, Beacon Hospital, Sandyford, Dublin 18, Ireland.

Background: The surgical management of deep brain lesions is challenging, with significant morbidity. Advances in surgical technology have presented the opportunity to tackle these lesions.

Methods: We performed a complete resection of a thalamic/internal capsule CM using a tubular retractor system via a parietal trans-sulcal para-fascicular (PTPF) approach without collateral injury to the nearby white matter tracts. Read More

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Management of Chiari type I malformation: a retrospective analysis of a series of 91 children treated surgically.

Acta Neurochir (Wien) 2021 Jun 23. Epub 2021 Jun 23.

Department of Pediatric Neurosurgery, Hôpital Femme Mère Enfant, 32 Avenue du Doyen Jean Lépine, 69677, Lyon Cedex, France.

Introduction: The diagnosis of Chiari I malformation, its symptomatology, and the results of its surgical management are still discussed. We report a pediatric series of CMI without associated skull base malformations or cerebellar growth anomalies operated between 2001 and 2018.

Material And Methods: Ninety-one children out of 146 surgically treated cases have been included in the study. Read More

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Crystal structure of di-aqua-(3,14-diethyl-2,6,13,17-tetra-aza-tri-cyclo-[16.4.0.0]docosa-ne)copper(II) (3,14-diethyl-2,6,13,17-tetra-aza-tri-cyclo[16.4.0.0]docosa-ne)copper(II) tetra-bromide dihydrate, [Cu(CHN)(HO)][Cu(CHN)]Br·2HO.

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):677-680. Epub 2021 May 28.

Department of Chemistry, Andong National University, Andong 36729, Republic of Korea.

The crystal structure of the new double Cu complex salt, [Cu()(HO)][Cu()]Br·2HO ( = 3,14-diethyl-2,6,13,17-tetra-aza-tri-cyclo-[16.4.0. Read More

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Crystal structure and Hirshfeld surface analysis of 1-[()-2-(5-chloro-2-hy-droxy-phen-yl)hydrazin-1-yl-idene]naphthalen-2(1)-one.

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):672-676. Epub 2021 May 28.

Unité de Recherche de Chimie de l'Environnement et Moléculaire Structurale (URCHEMS), Département de Chimie, Université des Frères Mentouri de Constantine-1, 25000 Constantine, Algeria.

The title compound, CHClNO, was obtained by diazo-tization of 2-amino-4-chloro-phenol followed by a coupling reaction with β-naphthol. There are two mol-ecules ( and ) in the asymmetric unit. The crystal structure features only one type of inter-molecular inter-action, that is strong hydrogen bonds involving the hydroxyl group. Read More

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Tetra-kis[μ-1,1,1,3,3,3-hexa-fluoro-2-(tri-fluoro-meth-yl)propan-2-olato]tetra-kis-(μ-2-methyl-propan-2-olato)octa-copper(I).

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):668-671. Epub 2021 May 28.

Department of Chemistry, Howard University, 525 College Street NW, Washington DC 20059, USA.

The title compound, [Cu(CHO)(CFO)], crystallizes in the monoclinic space group, 2/ and contains a self-assembly of two CHCuFO units linked by bridging -butyl groups [Cu-O bonds of length 2.3779 (15) and 2.4248 (15) Å], generating a centrosymmetric dimer. Read More

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Crystal structure and Hirshfeld surface analysis of 2-{[7-acetyl-4-cyano-6-hy-droxy-8-(4-meth-oxy-phen-yl)-1,6-dimethyl-5,6,7,8-tetra-hydro-iso-quino-lin-3-yl]sulfan-yl}--phenyl-acetamide.

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):663-667. Epub 2021 May 28.

Chemistry Department, Faculty of Science, Taiz University, Taiz, Yemen.

The title mol-ecule, CHNOS, adopts a conformation with the two phenyl substituents disposed on opposite sides of the mean plane of the iso-quinoline unit. In the crystal, corrugated layers of mol-ecules are formed by N-H⋯O, C-H⋯N and C-H⋯S hydrogen bonds together with C-H⋯π(ring) inter-actions. These layers are connected by C-H⋯O contacts. Read More

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Crystal structure and mol-ecular docking study of ()-2-{[()-2-hy-droxy-5-methyl-benzyl-idene]hydrazinyl-idene}-1,2-di-phenyl-ethan-1-one.

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):658-662. Epub 2021 May 28.

Ondokuz Mayıs University, Faculty of Arts and Sciences, Department of Chemistry, 55139, Samsun, Turkey.

The title compound, CHNO, is a Schiff base that exists in the phenol-imine tautomeric form and adopts an configuration with respect to the C=N bond. The mol-ecular structure is stabilized by an O-H⋯N hydrogen bond, forming an (6) ring motif. In the crystal, pairs of C-H⋯O hydrogen bonds link the mol-ecules to form inversion dimers. Read More

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Crystal structure and photoreactive behaviour of ,-diisoprop-yl(-phenyl-phen-yl)glyoxyl-amide.

Acta Crystallogr E Crystallogr Commun 2021 Jun 28;77(Pt 6):653-657. Epub 2021 May 28.

Graduate School of Human and Environmental Studies, Kyoto University, Kyoto 606-8501, Japan.

The title compound [systematic name: 2-([1,1'-biphen-yl]-4-yl)-2-oxo-,-bis(propan-2-yl)acetamide], CHNO was synthesized and its photoreactive properties in the crystalline state and in aceto-nitrile solution were investigated. The compound crystallizes in the chiral space group 222. The crystal does not react under UV light irradiation, perhaps due to the presence of the biphenyl group. Read More

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μ-Methyl-ene-bis-[di-bromido(diethyl ether-κ)aluminium(III)]: crystal structure and chemical exchange in solution.

Acta Crystallogr E Crystallogr Commun 2021 Jun 21;77(Pt 6):647-652. Epub 2021 May 21.

Chemistry Division, Code 6123, Naval Research Laboratory, 4555 Overlook Av, SW, Washington DC 20375-5342, USA.

In the title compound, [AlBr(CH)(CHO)], the mol-ecule lies on a crystallographic twofold axis passing through the bridging C atom. Each Al atom is four-coordinate, being bonded to two bromide ions, bridging the CH group as well as the oxygen atom of a diethyl ether ligand in a slightly distorted tetra-hedral arrangement with angles ranging from 101.52 (8) to 116. Read More

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Crystal structure and Hirshfeld surface analysis of 2-(2-oxo-3-phenyl-1,2,3,8a-tetra-hydro-quinoxalin-1-yl)ethyl acetate.

Acta Crystallogr E Crystallogr Commun 2021 Jun 21;77(Pt 6):643-646. Epub 2021 May 21.

Laboratory of Medicinal Chemistry, Drug Sciences Research Center, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Morocco.

In the title mol-ecule, CHNO, the di-hydro-quinoxaline moiety, with the exception of the N atom is essentially planar with the inner part of the methyl-propano-ate group (CH-CH-O) nearly perpendicular to it. In the crystal, inversion dimers formed by C-H⋯O hydrogen bonds are connected into oblique stacks by π-stacking and C-H⋯π(ring) inter-actions. Read More

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Crystal structure, Hirshfeld surface analysis and DFT study of -(2-amino-5-methyl-phen-yl)-2-(5-methyl-1-pyrazol-3-yl)acetamide.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):638-642. Epub 2021 May 14.

Laboratory of Heterocyclic Organic Chemistry URAC 21, Pharmacochemistry Competence Center, Av. Ibn Battouta, BP 1014, Faculty of Sciences, Mohammed V University, Rabat, Morocco.

The title mol-ecule, CHNO, adopts an angular conformation. In the crystal a layer structure is generated by N-H⋯O and N-H⋯N hydrogen bonds together with C-H⋯π(ring) inter-actions. Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H⋯H (53. Read More

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Ba(IO): crystal structure evolution from room temperature to 80 K.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):634-637. Epub 2021 May 14.

Crystal Growth Facility, Institute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.

The crystal structure of Ba(IO), penta-barium bis-(orthoperiodate), has been re-investigated at room temperature based on single-crystal X-ray diffraction data. In comparison with a previous crystal structure determination by the Rietveld method, an improved precision of the structural parameters was achieved. Additionally, low-temperature measurements allowed the crystal structure evolution to be studied down to 80 K. Read More

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Crystal structure and Hirshfeld surface analysis of bis-(6,7,8,9-tetra-hydro-11-pyrido[2,1-]quinazolin-5-ium) tetra-chlorido-zincate.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):629-633. Epub 2021 May 14.

S.Yunusov Institute of Chemistry of Plant Substances, Academy of Science of Uzbekistan, Mirzo Ulugbek Str. 77, 100170 Tashkent, Uzbekistan.

The title compound, (CHN)[ZnCl], is a salt with two symmetrically independent, essentially planar heterocyclic cations and a slightly distorted tetra-hedral chloro-zincate dianion. N-H⋯Cl hydrogen bonds link these ionic constituents into a discrete aggregate, which comprises one formula unit. The effect of hydrogen bonding is reflected in the minor distortions of the [ZnCl] moiety: distances between the cation and chlorido ligands engaged in classical hydrogen bonds are significantly longer than the others. Read More

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Synthesis and crystal structures of 3,6-di-hydroxy-picolinic acid and its labile inter-mediate dipotassium 3-hy-droxy-6-(sulfonato-oxy)pyridine-2-carboxyl-ate monohydrate.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):623-628. Epub 2021 May 14.

Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, Kentucky, 40506, USA.

A simplified two-step synthesis of 3,6-di-hydroxy-picolinic acid (3-hy-droxy-6-oxo-1,6-di-hydro-pyridine-2-carb-oxy-lic acid), CHNO (), an inter-mediate in the metabolism of picolinic acid, is described. The crystal structure of , along with that of a labile inter-mediate, dipotassium 3-hy-droxy-6-(sulfonato-oxy)pyridine-2-carboxyl-ate monohydrate, 2K·CHNOS·HO (), is also described. Compound comprises a pyridine ring with carboxyl-ate, hydroxyl (connected by an intra-molecular O-H⋯O hydrogen bond), and sulfate groups at the 2-, 3-, and 6-positions, respectively, along with two potassium cations for charge balance and one water mol-ecule of crystallization. Read More

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Synthesis and crystal structures of -H, -phenyl and -benzyl-2-(4-hexyl-oxyphen-yl)benzimidazoles.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):618-622. Epub 2021 May 14.

N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian, Academy of Sciences, Leninsky pr. 31, Moscow 119991, Russian Federation.

The title compounds, 2-(4-hexyl-oxyphen-yl)-1-benzimidazole (CHNO; ), 2-(4-hexyl-oxyphen-yl)-1-phenyl-1-benzimidazole (CHNO; ) and 1-benzyl-2-(4-hexyl-oxyphen-yl)-1-benzimidazole (CHNO; ) were synthesized and their structures were determined by single-crystal X-ray analysis. The N-substituent at the imidazole moiety slightly affects the inter-planar angle between the 4-hexyl-oxyphenyl ring and the benzimidazole system. The unsubstituted benzimidazole () forms inter-molecular N-H⋯N bonds while in the crystal structures of and , the mol-ecules are assembled only through π-π and C-H⋯π inter-actions. Read More

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Crystal structure of ethyl 2-(3-amino-5-oxo-2-tosyl-2,5-di-hydro-1-pyrazol-1-yl)acetate.

Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):615-617. Epub 2021 May 14.

Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Hagenring 30, D-38106 Braunschweig, Germany.

In the title compound, CHNOS, the five-membered ring is essentially planar. The substituents at the nitro-gen atoms subtend a C-N-N-S torsion angle of -95.52 (6)°. Read More

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