Acta Crystallogr E Crystallogr Commun 2021 Jun 14;77(Pt 6):623-628. Epub 2021 May 14.
Department of Chemistry, University of Kentucky, 505 Rose Street, Lexington, Kentucky, 40506, USA.
A simplified two-step synthesis of 3,6-di-hydroxy-picolinic acid (3-hy-droxy-6-oxo-1,6-di-hydro-pyridine-2-carb-oxy-lic acid), CHNO (), an inter-mediate in the metabolism of picolinic acid, is described. The crystal structure of , along with that of a labile inter-mediate, dipotassium 3-hy-droxy-6-(sulfonato-oxy)pyridine-2-carboxyl-ate monohydrate, 2K·CHNOS·HO (), is also described. Compound comprises a pyridine ring with carboxyl-ate, hydroxyl (connected by an intra-molecular O-H⋯O hydrogen bond), and sulfate groups at the 2-, 3-, and 6-positions, respectively, along with two potassium cations for charge balance and one water mol-ecule of crystallization. Read More