3,312 results match your criteria Acta Biochimica Et Biophysica Sinica[Journal]


TBK1, a central kinase in innate immune sensing of nucleic acids and beyond.

Acta Biochim Biophys Sin (Shanghai) 2020 May 27. Epub 2020 May 27.

MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Sensing of intracellular and extracellular environments is one of the fundamental processes of cell. Surveillance of aberrant nucleic acids, derived either from invading pathogens or damaged organelle, is conducted by pattern recognition receptors (PRRs) including RIG-I-like receptors, cyclic GMP-AMP synthase, absent in melanoma 2, and a few members of toll-like receptors. TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes. Read More

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http://dx.doi.org/10.1093/abbs/gmaa051DOI Listing

Nkx2.1 downregulation is involved in brain abnormality induced by excess retinoic acid.

Acta Biochim Biophys Sin (Shanghai) 2020 May 23. Epub 2020 May 23.

Department of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Taiyuan 030001, China.

Abnormal development of central nervous system (CNS) caused by neural tube defects is not only a major contributor in the prevalence of stillbirths and neonatal deaths but also causes lifelong physical disability in surviving infants. Due to insufficient known investigated causes, CNS developmental abnormality has brought sever burden on health around the world. From previous results of high throughput transcriptome sequencing, we selected transcription factor Nkx2. Read More

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http://dx.doi.org/10.1093/abbs/gmaa037DOI Listing

Regulation of alveolar type 2 stem/progenitor cells in lung injury and regeneration.

Authors:
Ailing Wu Hai Song

Acta Biochim Biophys Sin (Shanghai) 2020 May 23. Epub 2020 May 23.

MOE Laboratory of Biosystems Homeostasis and Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

The renewal of lung epithelial cells is normally slow unless the lung is injured. The resident epithelial stem cells rapidly proliferate and differentiate to maintain lung structure and function when the lung is damaged. The alveolar epithelium is characterized by alveolar type 1 (AT1) and alveolar type 2 (AT2) cells. Read More

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http://dx.doi.org/10.1093/abbs/gmaa052DOI Listing

Recent advances and potential applications of human pluripotent stem cell-derived pancreatic β cells.

Acta Biochim Biophys Sin (Shanghai) 2020 May 23. Epub 2020 May 23.

MOE Laboratory of Biosystems Homeostasis and Protection, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Diabetes mellitus is characterized by chronic high blood glucose levels resulted from deficiency and/or dysfunction of insulin-producing pancreatic β cells. Generation of large amounts of functional pancreatic β cells is critical for the study of pancreatic biology and treatment of diabetes. Recent advances in directed differentiation of pancreatic β-like cells from human pluripotent stem cells (hPSCs) can provide patient-specific and disease-relevant target cells. Read More

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http://dx.doi.org/10.1093/abbs/gmaa047DOI Listing

Effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis.

Acta Biochim Biophys Sin (Shanghai) 2020 May 22. Epub 2020 May 22.

Department of Intensive Care Unit, The First Hospital of Jilin University, Changchun 130021, China.

In this study, we aimed to explore the effect of TrkB-PLC/IP3 pathway on intestinal inflammatory factors and enterocyte apoptosis in mice with colitis. The mouse model of ulcerative colitis was established by medication, and 40 SPF C57BL/6J mice (8 weeks old) were randomly divided into normal group (healthy mice, n = 10), control group (sham-operated mice, n = 10), model group (model mice without any treatment, n = 10), and K252a group (model mice treated with 100 μmol/kg TrkB-PLC/IP3 pathway inhibitor for 5 days before clysis, n = 10). The results showed that mice in the model and K252a groups, as compared with normal and control groups, had no significant changes in the levels and protein expressions of serum tumor necrosis factor-α (TNF-α) and TNF-γ in the colon tissues (P>0. Read More

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http://dx.doi.org/10.1093/abbs/gmaa044DOI Listing

The essential function of IL-33 in metabolic regulation.

Acta Biochim Biophys Sin (Shanghai) 2020 May 22. Epub 2020 May 22.

MOE Laboratory of Biosystem Homeostasis and Protection, and Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Interleukin-33 (IL-33) is produced by various types of cells under physical or pathological conditions. As a multifunctional partner in health and disease, current evidence reveals that IL-33 also participates in several metabolic processes. IL-33 has been proven to contribute to regulating the activity of ST2+ group 2 innate lymphoid cells and regulatory T cells in adipose, which leads to the shift of insulin sensitivity and glucose clearance in glucose metabolism, thermogenesis, and adipocyte beiging in adipose metabolism. Read More

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http://dx.doi.org/10.1093/abbs/gmaa045DOI Listing

Production of integrin αIIbβ3 in stably transfected and clonal Chinese hamster ovary cells for functional and structural studies.

Acta Biochim Biophys Sin (Shanghai) 2020 May 23. Epub 2020 May 23.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

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http://dx.doi.org/10.1093/abbs/gmaa055DOI Listing

Regulation and functions of the Hippo pathway in stemness and differentiation.

Acta Biochim Biophys Sin (Shanghai) 2020 May 23. Epub 2020 May 23.

MOE key Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China, and.

The Hippo pathway plays important roles in organ development, tissue regeneration, and human diseases, such as cancer. In the canonical Hippo pathway, the MST1/2-LATS1/2 kinase cascade phosphorylates and inhibits transcription coactivators Yes-associated protein and transcription coactivator with PDZ-binding motif and thus regulates transcription of genes important for cell proliferation and apoptosis. However, recent studies have depicted a much more complicate picture of the Hippo pathway with many new components and regulatory stimuli involving both chemical and mechanical signals. Read More

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http://dx.doi.org/10.1093/abbs/gmaa048DOI Listing

Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain, liver and skeletal muscle.

Acta Biochim Biophys Sin (Shanghai) 2020 May 19. Epub 2020 May 19.

Department of Cardiology, Zhongshan Hospital Fudan University and Shanghai Institute of Cardiovascular Diseases, Shanghai 200032, China.

Alcoholism leads to organ injury including mitochondrial defect and apoptosis with evidence favoring a role for autophagy dysregulation in alcoholic damage. Parkin represents an autosomal recessive inherited gene for Parkinson's disease and an important member of selective autophagy for mitochondria. The association between Parkinson's disease and alcoholic injury remains elusive. Read More

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http://dx.doi.org/10.1093/abbs/gmaa041DOI Listing

miR-487a performs oncogenic functions in osteosarcoma by targeting BTG2 mRNA.

Acta Biochim Biophys Sin (Shanghai) 2020 May 13. Epub 2020 May 13.

Department of Orthopedics, Hwa Mei Hospital, University of Chinese Academy of Sciences (Ningbo No. 2 Hospital), Ningbo 315000, China.

Aberrant microRNA (miRNA) expression plays a critical role in osteosarcoma (OS) pathogenesis. In this study, we elucidated the involvement of miR-487a in OS and the underlying molecular mechanisms. We found that miR-487a was upregulated in OS clinical samples and cell lines. Read More

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http://dx.doi.org/10.1093/abbs/gmaa034DOI Listing

Knockdown of Nav1.5 inhibits cell proliferation, migration and invasion via Wnt/β-catenin signaling pathway in oral squamous cell carcinoma.

Acta Biochim Biophys Sin (Shanghai) 2020 May 13. Epub 2020 May 13.

College and Hospital of Stomatology, Anhui Medical University, Key Laboratory of Oral Diseases Research of Anhui Province, Hefei 230032, China.

Oral squamous cell carcinoma (OSCC) is a common type of malignant oral cancer that has a high recurrence rate. Voltage-gated sodium channel Nav1.5 was reported to be highly up-regulated in various types of cancers. Read More

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http://dx.doi.org/10.1093/abbs/gmaa021DOI Listing

Structural and functional studies revealed key mechanisms underlying elongation step of protein translation.

Acta Biochim Biophys Sin (Shanghai) 2020 May 13. Epub 2020 May 13.

Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

The ribosome is an ancient and universally conserved macromolecular machine that synthesizes proteins in all organisms. Since the discovery of the ribosome by electron microscopy in the mid-1950s, rapid progress has been made in research on it, regarding its architecture and functions. As a machine that synthesizes polypeptides, the sequential addition of amino acids to a growing polypeptide chain occurs during a phase called the elongation cycle. Read More

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http://dx.doi.org/10.1093/abbs/gmaa046DOI Listing
May 2020
2.191 Impact Factor

Reverse engineering a predictive signature characterized by proliferation, DNA damage, and immune escape from stage I lung adenocarcinoma recurrence.

Acta Biochim Biophys Sin (Shanghai) 2020 May 12. Epub 2020 May 12.

Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.

Identifying early-stage cancer patients at risk for progression is a major goal of biomarker research. This report describes a novel 19-gene signature (19-GCS) that predicts stage I lung adenocarcinoma (LAC) recurrence and response to therapy and performs comparably in pancreatic adenocarcinoma (PAC), which shares LAC molecular traits. Kaplan-Meier, Cox regression, and cross-validation analyses were used to build the signature from training, test, and validation sets comprising 831 stage I LAC transcriptomes from multiple independent data sets. Read More

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http://dx.doi.org/10.1093/abbs/gmaa036DOI Listing

circStrn3 is involved in bone cancer pain regulation in a rat model.

Acta Biochim Biophys Sin (Shanghai) 2020 May 12. Epub 2020 May 12.

Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Bone cancer pain (BCP) is a common chronic pain that is caused by a primary or metastatic bone tumor. More detailed molecular mechanisms of BCP are warranted. In this study, we established a BCP rat model. Read More

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http://dx.doi.org/10.1093/abbs/gmaa018DOI Listing

Three-dimensional silk fibroin scaffolds enhance the bone formation and angiogenic differentiation of human amniotic mesenchymal stem cells: a biocompatibility analysis.

Acta Biochim Biophys Sin (Shanghai) 2020 May 11. Epub 2020 May 11.

Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.

Silk fibroin (SF) is a fibrous protein with unique mechanical properties, adjustable biodegradation, and the potential to drive differentiation of mesenchymal stem cells (MSCs) along the osteogenic lineage, making SF a promising scaffold material for bone tissue engineering. In this study, hAMSCs were isolated by enzyme digestion and identified by multiple-lineage differentiation. SF scaffold was fabricated by freeze-drying, and the adhesion and proliferation abilities of hAMSCs on scaffolds were determined. Read More

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http://dx.doi.org/10.1093/abbs/gmaa042DOI Listing

The antiatherogenic function of kallistatin and its potential mechanism.

Acta Biochim Biophys Sin (Shanghai) 2020 May 11. Epub 2020 May 11.

Department of Cardiology, The First Affiliated Hospital of University of South China, Institute of Cardiovascular Disease, Key Laboratory for Atherosclerology of Hunan Province, Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Medical Research Experiment Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hengyang Medical College, University of South China, Hengyang 421001, China.

Atherosclerosis is the pathological basis of most cardiovascular diseases, the leading cause of morbidity and mortality worldwide. Kallistatin, originally discovered in human serum, is a tissue-kallikrein-binding protein and a unique serine proteinase inhibitor. Upon binding to its receptor integrin β3, lipoprotein receptor-related protein 6, nucleolin, or Krüppel-like factor 4, kallistatin can modulate various signaling pathways and affect multiple biological processes, including angiogenesis, inflammatory response, oxidative stress, and tumor growth. Read More

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http://dx.doi.org/10.1093/abbs/gmaa035DOI Listing

Proteome alterations in brains of KKAy diabetic mice imply the underling molecular links between diabetes and Parkinson's disease.

Acta Biochim Biophys Sin (Shanghai) 2020 May 11. Epub 2020 May 11.

School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

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http://dx.doi.org/10.1093/abbs/gmaa033DOI Listing

Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP/PKA/RhoA/ROCK2 signaling.

Acta Biochim Biophys Sin (Shanghai) 2020 May 9. Epub 2020 May 9.

Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan 030006, China.

Myocardial hypertrophy is a major pathological and physiological process during heart failure. Glucagon-like peptide 1 (GLP-1) is a glucagon incretin hormone released from the gut endocrine L-cells that has protective effects on various cardiovascular diseases, including hypertension, atherosclerosis, and myocardial hypertrophy. However, the protective mechanisms of GLP-1 in myocardial hypertrophy remain unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmaa038DOI Listing

Suppression of microRNA-155 exerts an anti-inflammatory effect on CD4+ T cell-mediated inflammatory response in the pathogenesis of atherosclerosis.

Acta Biochim Biophys Sin (Shanghai) 2020 May 5. Epub 2020 May 5.

Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

In the current study, we aimed to investigate the effects of miR-155 on CD4+ T cell-mediated immune response in the pathogenesis of atherosclerosis. CD34+ hematopoietic stem cells, CD4+ T lymphocytes, endothelial cells (ECs), and vascular smooth muscle cells (VSMCs) were harvested from the same donor. Knockdown of miR-155 in the CD4+ T cells was achieved by lentiviral transfection, whereas control RNA-transfected or untransfected lymphocytes were used as controls. Read More

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http://dx.doi.org/10.1093/abbs/gmaa040DOI Listing

High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression.

Acta Biochim Biophys Sin (Shanghai) 2020 May 5. Epub 2020 May 5.

Department of Anesthesiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

Hyperglycemia-mediated reactive oxygen species (ROS) accumulation plays an important role in hyperglycemia-induced endothelial injury. Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway inhibition participates in hyperglycemia-induced ROS accumulation. Our previous study indicated that SET8 overexpression inhibits high glucose-mediated ROS accumulation in human umbilical vein endothelial cells (HUVECs). Read More

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http://dx.doi.org/10.1093/abbs/gmaa023DOI Listing

Folic acid supplement rescues ethanol-induced developmental defects in the zebrafish embryos.

Acta Biochim Biophys Sin (Shanghai) 2020 May 5. Epub 2020 May 5.

Children's Hospital, Fudan University, Shanghai 201102, China.

Fetal alcohol syndrome (FASD) describes a range of birth defects. Mechanisms of FASD-associated defects are not well understood. It has great significance to investigate whether nutrient supplements like folic acid (FA) can effectively rescue ethanol-induced defects. Read More

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http://dx.doi.org/10.1093/abbs/gmaa030DOI Listing

Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance.

Acta Biochim Biophys Sin (Shanghai) 2020 May 5. Epub 2020 May 5.

Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China.

Nowadays, drug-resistant microbes are becoming a serious clinical problem threatening people's health and life. Antimicrobial peptides (AMPs) are believed to be potential alternatives of conventional antibiotics to combat the threat of drug-resistant microbes. However, the susceptibility of AMPs toward proteases is one of the major problems limiting their clinical use. Read More

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http://dx.doi.org/10.1093/abbs/gmaa043DOI Listing

Exosomal piRNA profiling revealed unique circulating piRNA signatures of cholangiocarcinoma and gallbladder carcinoma.

Acta Biochim Biophys Sin (Shanghai) 2020 May 5. Epub 2020 May 5.

Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China.

Cholangiocarcinoma (CCA) and gallbladder carcinoma (GBC) are biliary tract cancers with poor five-year survival and high recurrences rates. Both CCA and GBC patients suffer from lack of circulating diagnostic biomarkers at the early stage. Extracellular vesicles, especially exosomes, have been emerged as promising diagnostic sources for cancers due to easy and quick accessibility. Read More

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http://dx.doi.org/10.1093/abbs/gmaa028DOI Listing

A COPII subunit interacting with ER-phagy receptor: a new potential avenue to maintaining neuronal homeostasis.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 29. Epub 2020 Apr 29.

Department of Pharmacology, Yongzhou Vocational Technical College, Yongzhou 425000, China.

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http://dx.doi.org/10.1093/abbs/gmaa031DOI Listing

Dispensable role of CCL28 in Kras-mutated non-small cell lung cancer mouse models.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 29. Epub 2020 Apr 29.

Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.

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http://dx.doi.org/10.1093/abbs/gmaa032DOI Listing

Mechanosensitive JCAD: emerged as a promising target for atherosclerosis.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 24. Epub 2020 Apr 24.

Department of Medical College, Hunan Polytechnic of Environment and Biology, Hengyang 421001, China.

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http://dx.doi.org/10.1093/abbs/gmaa019DOI Listing

miR-4458 inhibits the epithelial-mesenchymal transition of hepatocellular carcinoma cells by suppressing the TGF-β signaling pathway via targeting TGFBR1.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 23. Epub 2020 Apr 23.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China.

Hepatocellular carcinoma (HCC) is one of the most lethal cancers in the world. MicroRNAs play a pivotal role in the progression of various cancers. To date, very little attention has been paid to miR-4458. Read More

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http://dx.doi.org/10.1093/abbs/gmaa029DOI Listing

Massive reorganization of the genome during primary monocyte differentiation into macrophage.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 23. Epub 2020 Apr 23.

State Key Laboratory for Oncogenes and Related Genes and Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

Monocyte-to-macrophage trans-differentiation has long been studied to better understand this immunological response and aspects of developmental processes more generally. A key question is the nature of the corresponding changes in chromatin conformation and its relationship to the transcriptome during this process. This question is especially intriguing since this trans-differentiation is not associated with progression through mitosis, often considered a necessary step for gross changes in chromosomal structure. Read More

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http://dx.doi.org/10.1093/abbs/gmaa026DOI Listing

Plastin 1 promotes osteoblast differentiation by regulating intracellular Ca2.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 21. Epub 2020 Apr 21.

Center of Translational Medicine, Zibo Central Hospital, Shandong University, Zibo 255036, China.

Osteoblast differentiation is a key process in bone homeostasis. Mutations in plastin 3 have been reported to be responsible for X-linked osteoporosis. Plastin 3 and plastin 2 act synergistically to regulate osteoblast differentiation. Read More

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http://dx.doi.org/10.1093/abbs/gmaa027DOI Listing

KLF2 inhibits TGF-β-mediated cancer cell motility in hepatocellular carcinoma.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 21. Epub 2020 Apr 21.

Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanchang University, Nanchang 330006, China.

Feedback regulation plays a pivotal role in determining the intensity and duration of TGF-β signaling and subsequently affecting the pathophysiological roles of TGF-β, including those in liver malignancy. KLF2, a member of the Krüppel-like factor (KLF) family transcription factors, has been implicated in impeding hepatocellular carcinoma (HCC) development. However, the underlying molecular mechanisms are not fully understood. Read More

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http://dx.doi.org/10.1093/abbs/gmaa024DOI Listing

Rho kinase mediates transforming growth factor-β1-induced vasculogenic mimicry formation: involvement of the epithelial-mesenchymal transition and cancer stemness activity.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):411-420

Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.100 Haining Road, Shanghai 200080, PR China.

Vasculogenic mimicry (VM), a newly defined pattern of tumor blood supply, has been identified in several malignant tumors, including hepatocellular carcinoma (HCC). Rho kinase (ROCK) plays an important role in various types of cancers. However, whether ROCK participates in transforming growth factor-β1 (TGF-β1)-induced VM formation is unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmaa014DOI Listing

Gasdermins: pore-forming activities and beyond.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 15. Epub 2020 Apr 15.

The Joint Center for Infection and Immunity between Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China.

Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (a.k.a. Read More

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http://dx.doi.org/10.1093/abbs/gmaa016DOI Listing

3-Methylcholanthrene alters the hepatic immune response in mice.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 15. Epub 2020 Apr 15.

College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.

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http://dx.doi.org/10.1093/abbs/gmaa020DOI Listing

Up-regulation of miR-139-5p protects diabetic mice from liver tissue damage and oxidative stress through inhibiting Notch signaling pathway.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):390-400

Department of General Practice Medicine Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000, China.

The occurrence and development of diabetes seriously threaten the health of patients. Therefore, the mechanism exploration of diabetes is of great significance for more effective control of this disease. In this study, we aimed to investigate the regulatory mechanism of miR-139-5p and Notch signaling pathway on liver damage and oxidative stress in diabetic mice. Read More

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http://dx.doi.org/10.1093/abbs/gmaa008DOI Listing
April 2020
2.191 Impact Factor

Inhibitory effect of cyclocytidine hydrochloride on vesicular stomatitis virus infection.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 14. Epub 2020 Apr 14.

Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou 215123, China.

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http://dx.doi.org/10.1093/abbs/gmaa017DOI Listing
April 2020
2.191 Impact Factor

Osteoporosis-decreased extracellular matrix stiffness impairs connexin 43-mediated gap junction intercellular communication in osteocytes.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 14. Epub 2020 Apr 14.

State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610064, China.

Osteocytes are the main sensitive and responsive cells for mechanical stimuli in bone. The connexin family enables them to communicate with each other via forming functional gap junctions. However, how osteoporosis-impaired extracellular mechanical property modulates gap junction intercellular communication in osteocytes remains elusive. Read More

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http://dx.doi.org/10.1093/abbs/gmaa025DOI Listing
April 2020
2.191 Impact Factor

A novel Lyn-like protein tyrosine kinase identified in lamprey and its role in immune response.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr 14. Epub 2020 Apr 14.

College of Life Science, Liaoning Normal University, Dalian 116081, China.

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http://dx.doi.org/10.1093/abbs/gmaa022DOI Listing

Comparative phosphoproteomic analysis of compatible and incompatible pollination in Brassica napus L.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):446-456

National Key Laboratory of Crop Genetic Improvement, National Center of Rapeseed Improvement in Wuhan, Huazhong Agricultural University, Wuhan 430070, China.

Self-incompatibility (SI) promotes outbreeding and prevents self-fertilization to promote genetic diversity in angiosperms. Several studies have been carried to investigate SI signaling in plants; however, protein phosphorylation and dephosphorylation in the fine-tuning of the SI response remain insufficiently understood. Here, we performed a phosphoproteomic analysis to identify the phosphoproteins in the stigma of self-compatible 'Westar' and self-incompatible 'W-3' Brassica napus lines. Read More

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http://dx.doi.org/10.1093/abbs/gmaa011DOI Listing

Novel cyclophosphamide of natural products osalmide and pterostilbene induces cytotoxicity and cell cycle arrest in diffuse large B-cell lymphoma cells.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):401-410

Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Diffuse large B-cell lymphoma (DLBCL) is the most common category and disease entity of non-Hodgkin lymphoma. Osalmide and pterostilbene are natural products with anticancer activities via different mechanism. In this study, using a new synthetic strategy for the two natural products, we obtained the compound DCZ0801, which was previously found to have anti-multiple myeloma activity. Read More

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http://dx.doi.org/10.1093/abbs/gmaa009DOI Listing

Nrf2/ARE pathway activation is involved in negatively regulating heat-induced apoptosis in non-small cell lung cancer cells.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):439-445

Department of Respiratory Medicine, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, China.

Hyperthermia, particularly in combination with chemoradiotherapy, is widely used to treat various cancers. However, hyperthermia treatment is often insufficient due to thermo-tolerance. To date, the detailed mechanism underlying thermo-tolerance has not been clarified. Read More

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http://dx.doi.org/10.1093/abbs/gmaa013DOI Listing

The role of human cytomegalovirus in atherosclerosis: a systematic review.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):339-353

Clinical Laboratory, First Affiliated Hospital, University of South China, Hengyang 421001, China.

Atherosclerosis is a progressive vascular disease with increasing morbidity and mortality year by year in modern society. Human cytomegalovirus (HCMV) infection is closely associated with the development of atherosclerosis. HCMV infection may accelerate graft atherosclerosis and the development of transplant vasculopathy in organ transplantation. Read More

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http://dx.doi.org/10.1093/abbs/gmaa005DOI Listing

Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):421-429

School of Basic Medical Sciences, Nanchang University, Nanchang 330006, China.

Local hypoxia is a universal phenomenon in most solid tumors. The role of local hypoxia in the tumor microenvironment and cancer growth and metastasis has been well established. However, the effect of acute systemic hypoxia (exposing the whole body to 10% O2 environment) on cancer has not yet been investigated. Read More

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http://dx.doi.org/10.1093/abbs/gmaa010DOI Listing

LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):382-389

Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.

In recent decades, the incidence rate of papillary thyroid carcinoma (PTC) has been rapidly increasing. However, the molecular mechanism of the physiological and pathological processes of PTC is still largely unknown. Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) is a tumor suppressor and exerts anti-tumor effect in several human cancers, while the role and underlying mechanism of LHPP in PTC remain vague. Read More

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http://dx.doi.org/10.1093/abbs/gmaa015DOI Listing

MIR205HG facilitates carcinogenesis of lung squamous cell carcinoma in vitro revealed by long noncoding RNA profiling.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):371-381

Departments of Respiratory Medicine, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

As a subtype of non-small-cell lung cancer, lung squamous cell carcinoma (LUSC) accounts for one-fifth of all lung cancers. Unfortunately, no specific targetable aberration has yet been identified. Hence, it is of huge urgency and potential to identify aberrantly regulated genes in LUSC. Read More

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http://dx.doi.org/10.1093/abbs/gmaa006DOI Listing
April 2020
2.191 Impact Factor

HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):345-362

Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

Osteosarcoma is the most common primary malignant bone tumor, which occurs in adolescents. As reported by our previous studies, HER4 indicates a poor prognosis of primary osteosarcoma. However, its mechanisms in the pathogenesis of osteosarcoma have not yet been studied. Read More

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http://dx.doi.org/10.1093/abbs/gmaa004DOI Listing

Bitter receptor member TAS2R4 may have neurobiological function beyond acting as a bitter receptor.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):460-462

Department of Endocrine, Shanghai Gongli Hospital, the Second Military Medical University, Shanghai 200135, China.

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http://dx.doi.org/10.1093/abbs/gmaa003DOI Listing

FoxM1 affects adhesive, migratory, and invasive abilities of human retinoblastoma Y-79 cells by targeting matrix metalloproteinase 2.

Acta Biochim Biophys Sin (Shanghai) 2020 Mar;52(3):294-301

Save Sight Institute, University of Sydney, Sydney, New South Wales 2000, Australia.

Forkhead box protein M1 (FoxM1) is an important transcription factor involved in various pathological processes including tumor metastasis. The changes of adhesive, migratory, and invasive abilities are considered as crucial events in tumor metastasis progression. In this study, we aimed to investigate the correlation between FoxM1 and retinoblastoma (Rb) metastasis and to explore the detailed mechanism. Read More

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http://dx.doi.org/10.1093/abbs/gmz160DOI Listing

Macrophage amphiregulin-pericyte TGF-β axis: a novel mechanism of the immune system that contributes to wound repair.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):463-465

Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang 421001, China.

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http://dx.doi.org/10.1093/abbs/gmaa001DOI Listing
April 2020
2.191 Impact Factor

Significant improvement in data quality with simplified SCRB-seq.

Acta Biochim Biophys Sin (Shanghai) 2020 Apr;52(4):457-459

Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.

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http://dx.doi.org/10.1093/abbs/gmaa007DOI Listing

High intratumoral expression of eIF4A1 promotes epithelial-to-mesenchymal transition and predicts unfavorable prognosis in gastric cancer.

Acta Biochim Biophys Sin (Shanghai) 2020 Mar;52(3):310-319

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Gastric cancer is an important health problem, being the fifth most common cancer and the third leading cause of cancer-related death worldwide. Aberrant protein translation contributes to the oncogenesis and development of cancers, and upregulation of translation initiation factor eIF4A1 has been observed in several kinds of malignancies. However, the role of eIF4A1 in gastric cancer progression remains unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmz168DOI Listing