3,124 results match your criteria Acta Biochimica Et Biophysica Sinica[Journal]


Transcription factor Pf-Rel regulates expression of matrix protein genes Prismalin-14 and MSI60 in the pearl oyster Pinctada fucata.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 16. Epub 2019 Apr 16.

Protein Science Laboratory of the Ministry of Education, School of Life Science, Tsinghua University, Beijing, China.

Molluscan shell is a biomineral that consists of a highly organized calcium carbonate composite. Organisms mainly use matrix proteins to elaborately control the biomineralization process, but knowledge of their regulatory mechanisms is limited. The transcription factor Pf-Rel, which belongs to the Rel/nuclear factor-κB family, was shown to regulate transcription at the Nacrein promoter in the pearl oyster Pinctada fucata. Read More

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http://dx.doi.org/10.1093/abbs/gmz031DOI Listing

Reactive oxygen species accumulation patterns of alfalfa root nodules identified using an optimized method.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):448-451

Shanghai Key Laboratory of Bio-energy Crops, Plant Science Center, School of Life Sciences, Shanghai University, Shanghai, China.

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http://dx.doi.org/10.1093/abbs/gmz008DOI Listing
April 2019
1 Read

Production of a trioxacarcin analog by introducing a C-3 dehydratase into deoxysugar biosynthesis.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 10. Epub 2019 Apr 10.

State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmz024DOI Listing
April 2019
3 Reads
2.191 Impact Factor

The general transcriptional repressor Tup1 governs filamentous development in Candida tropicalis.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 10. Epub 2019 Apr 10.

State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Filamentous development is associated with the ability to cause infections and colonize the host in pathogenic Candida species. Candida tropicalis is one of the major fungal pathogens of humans. The conserved transcriptional repressor Tup1 plays a critical role in the regulation of transcription and filamentation in yeast species. Read More

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http://dx.doi.org/10.1093/abbs/gmz023DOI Listing

β-catenin/LIN28B promotes the proliferation of human choriocarcinoma cells via Let-7a repression.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 8. Epub 2019 Apr 8.

Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China.

Choriocarcinoma is a rare and malignant trophoblastic tumor. However, the molecular mechanisms by which choriocarcinoma is regulated remain unknown. In the present study, we first elucidated that LIN28B was highly expressed in human choriocarcinoma tissues and choriocarcinoma cell lines. Read More

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http://dx.doi.org/10.1093/abbs/gmz027DOI Listing
April 2019
2.191 Impact Factor

Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 4. Epub 2019 Apr 4.

Clinical Anatomy and Reproductive Medicine Application Institute, University of South China, Hengyang, China.

Sortilin is closely associated with hyperlipidemia and the risk of atherosclerosis (AS). The role of sortilin and the underlying mechanism in peripheral macrophage are not fully understood. In this study, we investigated the effect of macrophage sortilin on ATP-binding cassette transporter A1 (ABCA1) expression, ABCA1-mediated cholesterol efflux, and aortic AS. Read More

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http://dx.doi.org/10.1093/abbs/gmz029DOI Listing
April 2019
2.191 Impact Factor

DCZ0801, a novel compound, induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 4. Epub 2019 Apr 4.

CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Multiple myeloma (MM) is a refractory malignant hematological malignancy, and many therapeutic strategies have been developed to cure patients with MM. DCZ0801 is a compound that consists of oxophenamide and pterostilbene. The role of these compounds in hematological cancers such as MM has yet to be studied. Read More

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http://dx.doi.org/10.1093/abbs/gmz033DOI Listing
April 2019
2 Reads

Transcriptome profiling reveals the association of multiple genes and pathways contributing to hormonal control in celery leaves.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 2. Epub 2019 Apr 2.

State Key Laboratory of Crop Genetics and Germplasm Enhancement, Ministry of Agriculture and Rural Affairs, Key Laboratory of Biology and Germplasm Enhancement of Horticultural Crops in East China, College of Horticulture, Nanjing Agricultural University, Nanjing, China.

Celery is a vital vegetable belonging to the Apiaceae family. The leaves of celery are its main edible part with high nutritional value. Hormone signaling plays diverse and critical roles in controlling plant growth and development. Read More

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http://dx.doi.org/10.1093/abbs/gmz034DOI Listing
April 2019
1 Read

NLRP3 inflammasome mediates angiotensin II-induced islet β cell apoptosis.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 2. Epub 2019 Apr 2.

Key Laboratory of Cellular Physiology of Shanxi Medical University, Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan, China.

Elevation of angiotensin II (Ang II) in the serum of patients with diabetes is known to promote apoptosis of islet β cells, but the underlying mechanism remains unclear. The aim of the present study was to explore the role of Nod-like receptor protein 3 (NLRP3) inflammasome in Ang II-induced apoptosis of pancreatic islet β cells and investigate the possible underlying mechanism. The effect of Ang II on INS-1 cell (a rat insulinoma cell line) viability was detected by CCK-8 method. Read More

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http://dx.doi.org/10.1093/abbs/gmz032DOI Listing
April 2019
1 Read

FAM83D inhibits autophagy and promotes proliferation and invasion of ovarian cancer cells via PI3K/AKT/mTOR pathway.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr 2. Epub 2019 Apr 2.

Department of Obstetrics and Gynecology, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Ovarian cancer is one of the most lethal malignant tumors in women. The family with sequence similarity 83, member D (FAM83D) plays an important role in several cancers, but its function and underlying mechanism in ovarian cancer remain unknown. To investigate the role of FAM83D in ovarian cancer, the expression of FAM83D was determined by immunohistochemistry in tissue microarray slide. Read More

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http://dx.doi.org/10.1093/abbs/gmz028DOI Listing

Rapamycin- and starvation-induced autophagy are associated with miRNA dysregulation in A549 cells.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):393-401

Lab for Non-coding RNA & Cancer, School of Life Sciences, Shanghai University, Shanghai, China.

MicroRNAs (miRNAs) are short (20-23 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. In recent years, deep sequencing of the transcription is being increasingly utilized with the promise of higher sensitivity for the identification of differential expression patterns as well as the opportunity to discover new transcripts, including new alternative isoforms and miRNAs. In this study, miRNAs from A549 cells treated with/without rapamycin or starvation were subject to genome-wide deep sequencing. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmz022DOI Listing
April 2019
2 Reads

Molecular mechanism underlying Piriformospora indica-mediated plant improvement/protection for sustainable agriculture.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):229-242

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

The beneficial endophytic microorganisms have received significant attention in agriculture because of their exceptional capabilities to facilitate functions like nutrient enrichment, water status, and stress tolerance (biotic and abiotic). This review signifies the molecular mechanisms to better understand the Piriformospora indica-mediated plants improvement or protection for sustainable agriculture. P. Read More

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http://dx.doi.org/10.1093/abbs/gmz004DOI Listing

Argininosuccinate synthase 1 suppresses cancer cell invasion by inhibiting STAT3 pathway in hepatocellular carcinoma.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):263-276

State Key Laboratory of Oncogenes and Related Genes, Department of Tumor Microenvironment, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Metastasis is the main reason for high recurrence and poor survival of hepatocellular carcinoma (HCC). The molecular mechanism underlying HCC metastasis remains unclear. In this study, we found that argininosuccinate synthase 1 (ASS1) expression was significantly decreased and down-regulation of ASS1 was closely correlated with poor prognosis in HCC patients. Read More

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http://dx.doi.org/10.1093/abbs/gmz005DOI Listing

Liraglutide alleviates cardiac fibrosis through inhibiting P4hα-1 expression in STZ-induced diabetic cardiomyopathy.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):293-300

Department of Cardiology, the Second Hospital of Shandong University, Jinan, China.

Diabetic cardiomyopathy is an important contributor to morbidity and mortality of diabetic patients by causing heart failure. Interstitial and perivascular fibrosis plays a crucial role in diabetic cardiomyopathy. However, there is a lack of effective specific treatments available for diabetic cardiomyopathy. Read More

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http://dx.doi.org/10.1093/abbs/gmy177DOI Listing
March 2019
1 Read
2.191 Impact Factor

Upregulated KPNA2 promotes hepatocellular carcinoma progression and indicates prognostic significance across human cancer types.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):285-292

Third Department of Hepatic Surgery, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China.

Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide. Identification of the molecular mechanisms underlying the development and progression of HCC is particularly important. Here, we demonstrated the expression pattern, clinical significance, and function of Karyopherin α2 (KPNA2) in HCC. Read More

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http://dx.doi.org/10.1093/abbs/gmz003DOI Listing
March 2019
2.191 Impact Factor

Morphophysiological and molecular evidence supporting the augmentative role of Piriformospora indica in mitigation of salinity in Cucumis melo L.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):301-312

School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.

Salinity is one of the major limiting factors in plant growth and productivity. Cucumis melo L. is a widely cultivated plant, but its productivity is significantly influenced by the level of salinity in soil. Read More

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http://dx.doi.org/10.1093/abbs/gmz007DOI Listing
March 2019
2.191 Impact Factor

PRMT2β suppresses autophagy and glycolysis pathway in human breast cancer MCF-7 cell lines.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):335-337

Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, China.

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http://dx.doi.org/10.1093/abbs/gmz006DOI Listing
March 2019
3 Reads
2.191 Impact Factor

Association of SOST gene polymorphisms with peak bone mineral density in Chinese nuclear families with male-offspring.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):341-343

The Third Affiliated Hospital of Soochow University, Changzhou, China.

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http://dx.doi.org/10.1093/abbs/gmy175DOI Listing
March 2019
1 Read
2.191 Impact Factor

Anti-Toll-like receptor 2 antibody inhibits nuclear factor kappa B activation and attenuates cardiac damage in high-fat-feeding rats.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):347-355

Department of Biochemistry and Molecular Biology, Medical College of Xi'an Jiaotong University, Xi'an, China.

Long-time consumption of high-fat food is a direct cause of cardiovascular diseases, and high-fat-related inflammation plays an important role in it. Toll-like receptors (TLRs), especially TLR2 and TLR4, play important roles in high-fat-related inflammation. However, the impact of TLR2 on high-fat-associated cardiovascular complications is still unknown. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmz009DOI Listing
April 2019
2 Reads

Mogroside V inhibits LPS-induced COX-2 expression/ROS production and overexpression of HO-1 by blocking phosphorylation of AKT1 in RAW264.7 cells.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):365-374

Core Research Program 1515, Key Laboratory for Food Science and Biotechnology of Hunan Province, College of Food Science and Technology, Hunan Agricultural University, Changsha, China.

Momordica grosvenori is a valuable edible plant with medicinal purposes, and it is widely used in medicated diets and traditional Chinese medicine in Asia. Mogroside V (MV), the main bioactive component from M. grosvenori, is commonly used as a natural sweetener. Read More

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http://dx.doi.org/10.1093/abbs/gmz014DOI Listing
April 2019
2 Reads

Epigallocatechin-3-gallate inhibits angiotensin II-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):422-430

Institute of Clinical Epidemiology and Evidence-Based Medicine, Tongji University School of Medicine, Shanghai, China.

Angiotensin II (AII) has been well known to induce cardiomyocyte hypertrophy. Epigallocatechin-3-gallate (EGCG) is the main active component of green tea and it has been shown to exhibit strong cardioprotective potential, although the underlying molecular mechanisms remain unclear. In this study, we investigated the role and mechanism of EGCG in preventing AII-induced cardiomyocyte hypertrophy using rat H9c2 cardiomyocytes cells. Read More

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http://dx.doi.org/10.1093/abbs/gmz018DOI Listing

Sphingosine 1-phosphate induces epicardial progenitor cell differentiation into smooth muscle-like cells.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):402-410

Department of Cardiology, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Epicardial progenitor cells (EpiCs) which are derived from the proepicardium have the potential to differentiate into coronary vascular smooth muscle cells during development. Whether sphingosine 1-phosphate (S1P), a highly hydrophobic zwitterionic lysophospholipid in signal transduction, induces the differentiation of EpiCs is unknown. In the present study, we demonstrated that S1P significantly induced the expression of smooth muscle cell specific markers α-smooth muscle actin and myosin heavy chain 11 in the EpiCs. Read More

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http://dx.doi.org/10.1093/abbs/gmz017DOI Listing
April 2019
1 Read

PZR promotes metastasis of colorectal cancer through increasing FAK and Src phosphorylation.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):356-364

Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Metastasis is the main cause of death in patients with colorectal cancer (CRC), but the molecular mechanism is not yet fully understood. Previous studies have shown that P zero-related protein (PZR), a member of the immunoglobulin family, can promote fibronectin-dependent migration of mouse embryonic fibroblasts as well as invasion and metastasis of hepatic carcinoma cells. However, the role of PZR in CRC remains unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmz019DOI Listing

RIBOi: a database for ribosome-interacting proteins.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):441-443

Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1093/abbs/gmz013DOI Listing

LncRNA NEF is downregulated in triple negative breast cancer and correlated with poor prognosis.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):386-392

Department of Oncology, Shandong Academy of Medical Science, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China.

LncRNA NEF has been proved to be a tumor suppressor in liver cancer. In the present study, we found that lncRNA NEF was downregulated and miRNA-155 was upregulated in plasma of triple-negative breast cancer (TNBC) patients compared with those in controls. These two factors were inversely correlated only in TNBC patients but not in controls. Read More

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http://dx.doi.org/10.1093/abbs/gmz021DOI Listing

The combination of four cell-cycle regulators: a new direction for inducing adult cardiomyocyte proliferation.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):452-454

Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, China.

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http://dx.doi.org/10.1093/abbs/gmz012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460332PMC

TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):375-385

Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Gastric cancer is one of the most common cancers worldwide and is the third leading cause of cancer-related deaths globally. Although significant progress has been made in the diagnosis and treatment for the cancer, less improvement has been made in overall survival rate. Thus, there is an urgent need for a better understanding of the biological aspects of the cancer. Read More

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http://dx.doi.org/10.1093/abbs/gmz015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460344PMC

Mitochondria-targeted antioxidant peptide SS-31 mediates neuroprotection in a rat experimental glaucoma model.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):411-421

Department of Ophthalmology, Institute of Surgery Research, Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.

To investigate the neuroprotective effects of the mitochondria-targeted antioxidant Szeto-Schiller peptide 31 (SS-31) in a rat experimental glaucoma model, SS-31 was intraperitoneally (IP) injected into Sprague-Dawley rats, followed by intracameral injection of polystyrene microspheres to induce elevated intraocular pressure (IOP). After 6 weeks, electroretinography (ERG) and flash visual-evoked potentials (F-VEPs) were recorded to assess retinal function. Hematoxylin-eosin staining was performed on retinal cross-sections to measure ganglion cell complex (GCC) thickness. Read More

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http://dx.doi.org/10.1093/abbs/gmz020DOI Listing
April 2019
6 Reads
2.191 Impact Factor

Establishment of an in vitro reporter system for screening HBx-targeting molecules.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):431-440

Key Laboratory of Medical Molecular Virology (MOE/NHC), Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

Chronic hepatitis B virus (HBV) infection remains a global public health problem. HBV-encoded X protein (HBx) is a multifunctional regulator that is required to initiate and maintain productive HBV infection, and is involved in HBV-related hepatocellular carcinoma (HCC). Inhibitors that interfere with the functions of HBx could be useful not only for the inhibition of HBV replication but also for the prevention or treatment of HBV-related HCC. Read More

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http://dx.doi.org/10.1093/abbs/gmz016DOI Listing
April 2019
1 Read

Multiplex detection of transgenic maize by microdroplet PCR combined with capillary gel electrophoresis.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb 28. Epub 2019 Feb 28.

Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai, China.

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmz011DOI Listing
February 2019
4 Reads
2.191 Impact Factor

Diabetes-associated oxidative damage to DNA base in colon cells.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb 26. Epub 2019 Feb 26.

School of Life Sciences, Shanxi University, Taiyuan, China.

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http://dx.doi.org/10.1093/abbs/gmz010DOI Listing
February 2019

MiRNA-206 inhibits hepatocellular carcinoma cell proliferation and migration but promotes apoptosis by modulating cMET expression.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):243-253

Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital of Southern Medical University, Guangzhou, China.

A close relationship between cancer progression and microRNAs (miRNAs) regulation has been demonstrated. Abnormal microRNA-206 (miR-206) expression has been shown to be related to the development of malignancies. However, the role of miR-206 in hepatocellular carcinoma (HCC) remains unclear. Read More

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http://dx.doi.org/10.1093/abbs/gmy119DOI Listing
March 2019
1 Read

E2F is required for STAT3-mediated upregulation of cyclin B1 and Cdc2 expressions and contributes to G2-M phase transition.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):313-322

School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Activation of transcription factor STAT3 is involved in cell proliferation, differentiation, and cell survival. Constitutive activation of STAT3 pathway has been associated with the oncogenesis of various types of cancers. It has been reported that STAT3 plays a key role in the G1 to S phase cell cycle transition induced by the cytokine receptor subunit gp130, through the upregulation of cyclins D1, D2, D3, A, and Cdc25A and the concomitant downregulation of p21 and p27. Read More

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http://dx.doi.org/10.1093/abbs/gmy174DOI Listing
March 2019
1 Read

Proteasomal deubiquitinase UCH37 inhibits degradation of β-catenin and promotes cell proliferation and motility.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):277-284

Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, and College of Life Sciences, Beijing Normal University, Beijing, China.

The ubiquitin-proteasome system degrades most cellular proteins in eukaryotes. UCH37, also known as UCH-L5, is a deubiquitinase binding to Rpn13, a receptor for ubiquitinated substrates in the 26 S proteasome. But, it remains unclear how UCH37 influences the proteasomal degradation of the ubiquitinated substrates. Read More

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http://dx.doi.org/10.1093/abbs/gmy176DOI Listing
March 2019
1 Read

Differential localizations of protein phosphatase 1 isoforms determine their physiological function in the heart.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):323-330

Department of Biomedical Sciences, Grand Valley State University, Allendale, MI, USA.

Protein phosphatase 1 isoforms α, β, and γ (PP1α, PP1β, and PP1γ) are highly homologous in the catalytic domains but have distinct subcellular localizations. In this study, we utilized both primary cell culture and knockout mice to investigate the isoform-specific roles of PP1s in the heart. In both neonatal and adult cardiac myocytes, PP1β was mainly localized in the nucleus, compared to the predominant presence of PP1α and PP1γ in the cytoplasm. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422231PMC
March 2019
1 Read

miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):185-196

Department of Medical Cosmetology & Dermatology, The Affiliated Hospital of Nantong University, Nantong, China.

Keloids (KDs) and hypertrophic scars (HSs), two forms of pathological scars, seriously affect the physical and psychological health of patients. Despite many similarities with HSs, KDs are characterized by invasion and a high rate of recurrence after surgery, features they share in common with tumors. The underlying molecular mechanisms of this phenomenon have not been fully elucidated. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy165DOI Listing
February 2019
4 Reads

Vitamin D enzymes (CYP27A1, CYP27B1, and CYP24A1) and receptor expression in non-melanoma skin cancer.

Acta Biochim Biophys Sin (Shanghai) 2019 Apr;51(4):444-447

Institute for Health and Sport, Victoria University, Melbourne, Australia.

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy170DOI Listing
April 2019
9 Reads

Adiponectin attenuates lipopolysaccharide-induced cell injury of H9c2 cells by regulating AMPK pathway.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):168-177

Department of Cardiovascular Medicine, Jinan Central Hospital Affiliated to Shandong University, Ji'nan, China.

Adiponectin, an adipokine synthesized and secreted majorly by adipose tissue, is reported to exert cardioprotective properties via anti-inflammation and antiapoptosis. Lipopolysaccharide (LPS) is a common inflammation and apoptosis inducer of cardiomyocytes. However, few studies have reported the roles of adiponectin on LPS-induced inflammation as well as apoptosis of H9c2 cells, and the possible mechanisms of these effects. Read More

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http://dx.doi.org/10.1093/abbs/gmy162DOI Listing
February 2019

Differential effects of rapamycin on Bursaphelenchus xylophilus with different virulence and differential expression of autophagy genes under stresses in nematodes.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):254-262

Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing, China.

Pine wilt disease (PWD) caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus, is a devastating disease for Pinus spp. The virulence and resilience of PWN are closely linked to the spread and development of PWD. Numerous studies have shown that autophagy has important physiological and pathological functions in eukaryotes. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy172DOI Listing
March 2019
6 Reads

Chronic intermittent hypoxia accelerates liver fibrosis in rats with combined hypoxia and nonalcoholic steatohepatitis via angiogenesis rather than endoplasmic reticulum stress.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):159-167

Department of Gastroenterology, Huzhou Hospital, Zhejiang University School of Medicine, Huzhou, China.

In the present study, we aimed to investigate the role of endoplasmic reticulum stress (ERS) and its related inflammation and angiogenesis in liver fibrosis in a rat model of combined hypoxia and nonalcoholic steatohepatitis (NASH) and to confirm whether the intervention of hypoxia-inducible factor 1α (HIF1α) can improve fibrosis. Liver histological changes and biochemical indices, HIF1α, inflammatory factors, ERS-related parameters (GRP78, CHOP, caspase-3, and caspase-12), and angiogenesis indices (VEGFA, VEGFR2, and CD34) were evaluated. Compared with the control rats, the liver tissue of rats with hypoxia and NASH had obvious NASH characteristics and hepatic fibrosis was significantly aggravated, including bridging fibrosis in some rats. Read More

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http://dx.doi.org/10.1093/abbs/gmy169DOI Listing
February 2019

Piezo1: a novel mechanism of pressure-induced pancreatitis.

Acta Biochim Biophys Sin (Shanghai) 2019 Mar;51(3):344-345

Institute of Pharmacy and Pharmacology, Hunan Province Cooperative innovation Center for Molecular Target New Drugs Study, University of South China, Hengyang, China.

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http://dx.doi.org/10.1093/abbs/gmy173DOI Listing

The pretreatment of chronic restraint stress exerts little impact on the progression of heart failure in mice.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):204-215

Department of Translational Neuroscience, Jing'an District Centre Hospital of Shanghai, State Key Laboratory of Medical Neurobiology & Institutes of Brain Science, Fudan University, Shanghai, China.

Stress is a potent risk factor for depression. Chronic stress can exacerbate and induce symptoms of depression. Clinical studies suggested that depressive patients are more likely to develop coronary artery diseases. Read More

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http://dx.doi.org/10.1093/abbs/gmy168DOI Listing
February 2019
2 Reads

Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):139-149

High-Field NMR Center, Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.

Mycobacterium tuberculosis (Mtb) is the key devastating bacterial pathogen responsible for tuberculosis. Increasing emergence of multi-drug-resistant, extensively drug-resistant, and rifampicin/isoniazid-resistant strains of Mtb makes the discovery of validated drug targets an urgent priority. As a vital translational component of the protein biosynthesis system, elongation factor Tu (EF-Tu) is an important molecular switch responsible for selection and binding of the cognate aminoacyl-tRNA to the acceptor site on the ribosome. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy164DOI Listing
February 2019
10 Reads

MCPIP1 mediates inflammatory responses induced by lipopolysaccharide and lipoteichoic acid in bovine mammary epithelial cells.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):150-158

College of Veterinary Medicine, Northwest A&F University, Yangling, China.

Monocyte chemoattractant protein-induced protein 1 (MCPIP1) is a kind of zinc finger RNA binding protein, which exerts immune responses in a variety of cell types. However, the role of MCPIP1 in bovine mammary epithelial cells during mastitis has not been studied. In this study, we explored the functions of MCPIP1 in the inflammatory process induced by virulence factors of pathogens in bovine mammary alveolar cell-T (MAC-T) cell line. Read More

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http://dx.doi.org/10.1093/abbs/gmy163DOI Listing
February 2019

The glutamate biosynthetic pathway in brain: a novel mechanism of moderate UV-induced neurobehavioral changes.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):227-228

Hengyang Country People's Hospital, Hengyang, China.

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http://dx.doi.org/10.1093/abbs/gmy166DOI Listing
February 2019

Taurine-upregulated gene 1 contributes to cancers through sponging microRNA.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):123-130

Department of Biochemistry and Molecular Biology, Medical College of Nanchang University, Nanchang, China.

Long non-coding RNAs (lncRNAs) are a class of RNAs whose transcripts are more than 200 nucleotides in length and lack protein-coding ability. Taurine-upregulated gene 1 (TUG1), a novel cancer-related lncRNA, has been documented to be abnormally expressed in various types of cancers and act as an oncogene or anti-oncogene. It has been considered previously that TUG1 is closely related to the cell proliferation, invasion, metastasis, and apoptosis of cancer. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy156DOI Listing
February 2019
12 Reads

Propofol attenuates high glucose-induced P66shc expression in human umbilical vein endothelial cells through Sirt1.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):197-203

Department of Anaesthesiology, Fudan University Shanghai Cancer Center, Shanghai, China.

Perioperative hyperglycemia is a common metabolic disorder in clinic settings. Hyperglycemia leads to endothelial inflammation, endothelial cell apoptosis, and dysfunction, thus resulting in endothelial injury. Propofol (2,6-diisopropylphenol) is a widely used intravenous anesthetic in clinic settings. Read More

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http://dx.doi.org/10.1093/abbs/gmy167DOI Listing
February 2019
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Opposite effects of Drosophila C3PO on gene silencing mediated by esi-2.1 and miRNA-bantam.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):131-138

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China.

Translin/TRAX complex, also named as C3PO, is evolutionarily conserved and participates in diverse cellular processes in different organisms from yeast to human. C3PO plays a critical role in the activation of RNA-induced silencing complexes by promoting the unwinding and degradation of passenger strand of exogenous siRNAs (exo-siRNAs) in Drosophila and human. Moreover, human C3PO (hC3PO) has been found to broadly repress miRNAs by degrading miRNA precursors. Read More

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https://academic.oup.com/abbs/advance-article/doi/10.1093/ab
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http://dx.doi.org/10.1093/abbs/gmy154DOI Listing
February 2019
8 Reads

Discovery and genetic characterization of intestinal metaplasia in the Helicobacter felis-infected mouse model of gastric cancer.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):219-222

Bio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

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http://dx.doi.org/10.1093/abbs/gmy160DOI Listing
February 2019
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Identification and functional characterization of a novel missense mutation in FRMD7 responsible for idiopathic congenital nystagmus.

Acta Biochim Biophys Sin (Shanghai) 2019 Feb;51(2):178-184

Department of Ophthalmology, The First Hospital of Jilin University, Changchun, China.

Idiopathic congenital nystagmus (ICN) is a genetically heterogeneous eye movement disorder which seriously reduces childhood visual acuity. X-linked inheritance is the most common pattern, and mutations in FERM domain-containing protein 7 (FRMD7) are the major cause. Here, we recruited a four-generation Chinese family with X-linked ICN for the causative mutational screening of FRMD7. Read More

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http://dx.doi.org/10.1093/abbs/gmy161DOI Listing
February 2019