3,498 results match your criteria Acta Biochimica Et Biophysica Sinica[Journal]


Recombinant Lactobacillus plantarum NC8 strain expressing porcine rotavirus VP7 induces specific antibodies in BALB/c mice.

Acta Biochim Biophys Sin (Shanghai) 2021 May 8. Epub 2021 May 8.

College of Animal Science and Technology, Jilin Provincial Engineering Research Center of Animal Probiotics, Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural University, Changchun 130118, China.

The major etiologic agent that causes acute gastroenteritis worldwide in young animals and children is Group A rotavirus. Currently, commercially available vaccines do not often prevent porcine rotavirus (PRV) infection. In this study, we evaluated the efficacy of oral recombinant Lactobacillus vaccine against PRV in a mouse model. Read More

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Dasatinib inhibits proliferation of liver cancer cells, but activation of Akt/mTOR compromises dasatinib as a cancer drug.

Acta Biochim Biophys Sin (Shanghai) 2021 May 7. Epub 2021 May 7.

Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan 030001, China.

Dasatinib is a multi-target protein tyrosine kinase inhibitor. Due to its potent inhibition of Src, Abl, the platelet-derived growth factor receptor (PDGFR) family kinases, and other oncogenic kinases, it has been investigated as a targeted therapy for a broad spectrum of cancer types. However, its efficacy has not been significantly extended beyond leukemia. Read More

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miR-378c suppresses Wilms tumor development via negatively regulating CAMKK2.

Acta Biochim Biophys Sin (Shanghai) 2021 May 6. Epub 2021 May 6.

Department of Paediatric Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Wilms tumor is a rare kidney malignancy primarily developed in children. Treatment for Wilms tumor includes surgery, radiotherapy, and chemotherapy. Recent studies have demonstrated that microRNAs (miRNAs) play important roles in regulating Wilms tumor development. Read More

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Impact of mitochondrial aldehyde dehydrogenase 2 on cognitive impairment in the AD model mouse.

Acta Biochim Biophys Sin (Shanghai) 2021 May 6. Epub 2021 May 6.

Department of General Practice, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Alzheimer's disease (AD) is one of the major life-threatening diseases for the elderly because neither pathogenesis nor effective treatment is available. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) has been shown to reduce the cell-damaging aldehydes in response to reactive oxygen species (ROS). However, whether it plays a role in AD remains elusive. Read More

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PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.

Acta Biochim Biophys Sin (Shanghai) 2021 May 6. Epub 2021 May 6.

Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, China.

Pre-mRNA processing factor 19 (PRPF19) is a multifaceted protein and participates in DNA damage response and pre-mRNA processing. The role of PRPF19 in cancer is unclear. Here, we report that the expression of PRPF19 in human tongue cancer is associated with unfavorable prognosis. Read More

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Activation of anterior thalamic reticular nucleus GABAergic neurons promotes arousal from propofol anesthesia in mice.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 30. Epub 2021 Apr 30.

Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai 200031, China.

Propofol is widely used for the induction and maintenance of anesthesia, which causes a rapid loss of consciousness. However, the mechanisms underlying the hypnosis effect of propofol are still not fully understood. The thalamic reticular nucleus (TRN) is crucial for regulating wakefulness, sleep rhythm generation, and sleep stability, while the role of TRN in the process of propofol-induced anesthesia is still unknown. Read More

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An oncolytic adenovirus delivering TSLC1 inhibits Wnt signaling pathway and tumor growth in SMMC-7721 xenograft mice model.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 30. Epub 2021 Apr 30.

Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 311402, China.

Tumor suppressor in lung cancer-1 (TSLC1) was first identified as a tumor suppressor for lung cancer, and frequently downregulated in various types of cancers including hepatocellular carcinoma (HCC). The Wnt pathway plays a critical role in tumorigenesis, migration, and invasion in HCC. However, the function of TSLC1 in modulating Wnt signaling in HCC is unclear. Read More

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Autoantibody against angiotensin II type I receptor induces pancreatic β-cell apoptosis via enhancing autophagy.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 30. Epub 2021 Apr 30.

Key Laboratory of Cellular Physiology (Shanxi Medical University), Ministry of Education, and the Department of Physiology, Shanxi Medical University, Taiyuan 030001, China.

Autoantibody against the angiotensin II type I receptor (AT1-AA) has been found in the serum of patients with diabetes mellitus (DM). However, it remains unclear whether AT1-AA induces β-cell apoptosis and participates in the development of DM. In this study, an AT1-AA-positive rat model was set up by active immunization, and AT1-AA IgG was purified. Read More

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AKR1B10 protects against UVC-induced DNA damage in breast cancer cells.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 29. Epub 2021 Apr 29.

Department of Laboratory Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen 518000, China.

The cellular response to DNA damage is crucial for maintaining the integrity and stability of molecular structure. To maintain genome stability, DNA-damaged cells should be arrested so that mutations can be repaired before replication. Although several key components required for this arrest have been discovered, the majority of the pathways are still unclear. Read More

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Exosomal lncRNA-p21 derived from mesenchymal stem cells protects epithelial cells during LPS-induced acute lung injury by sponging miR-181.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 23. Epub 2021 Apr 23.

Emergency Department, The First Hospital of China Medical University, Shenyang 110001, China.

Long noncoding RNAs (lncRNAs) act as essential regulators of various diseases. However, the functions of lncRNAs in sepsis-induced acute lung injury (SALI) remain unclear. Here, we found that lipopolysaccharide could upregulate lncRNA-p21 expression in mesenchymal stem cells (MSCs) in a time- and dose-dependent manner and that lncRNA-p21 was packaged into exosomes. Read More

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Resveratrol induces AMPK and mTOR signaling inhibition-mediated autophagy and apoptosis in multiple myeloma cells.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 23. Epub 2021 Apr 23.

Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Resveratrol, a natural compound extracted from the skins of grapes, berries, or other fruits, has been shown to have anti-tumor effects against multiple myeloma (MM) via promoting apoptosis and inhibiting cell viability. In addition to apoptosis, autophagy also plays a significant role in anti-tumor effects. However, whether autophagy is involved in anti-MM activity of resveratrol remains unclear. Read More

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Intercellular mitochondria transfer: a new perspective for the treatment of metabolic diseases.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 23. Epub 2021 Apr 23.

Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, China.

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Exosomal LINC00355 derived from cancer-associated fibroblasts promotes bladder cancer cell proliferation and invasion by regulating miR-15a-5p/HMGA2 axis.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 21. Epub 2021 Apr 21.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.

We have previously demonstrated that exosomes derived from cancer-associated fibroblasts (CAFs) promote bladder cancer (BC) cell proliferation and invasion by transferring LINC00355. In this study, the molecular mechanisms underlying the pro-bladder cancer action of exosomal LINC00355 were explored. CAFs were obtained from BC tumor tissues, and normal fibroblasts (NFs) were obtained from adjacent normal tissues. Read More

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Rapid and sensitive detection of Vibrio alginolyticus pathogenic strains by real-time recombinase polymerase amplification.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 19. Epub 2021 Apr 19.

Jiangsu Key Laboratory of Marine Biological Resources and Environment, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China.

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Identification of Sinorhizobium meliloti LsrB regulon.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 19. Epub 2021 Apr 19.

Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai 200444, China.

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Long non-coding RNA SNHG14 aggravates LPS-induced acute kidney injury through regulating miR-495-3p/HIPK1.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 15. Epub 2021 Apr 15.

Department of Emergency, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China.

Acute kidney injury (AKI) is a complex syndrome with an abrupt decrease of kidney function, which is associated with high morbidity and mortality. Sepsis is the common cause of AKI. Mounting evidence has demonstrated that long non-coding RNAs (lncRNAs) play critical roles in the development and progression of sepsis-induced AKI. Read More

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Novel role of LINC01013/miR-6795-5p/FMNL3 axis in the regulation of hepatocellular carcinoma stem cell features.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr 13. Epub 2021 Apr 13.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.

Cancer stem cells (CSCs) are major contributors to tumor initiation, recurrence, and metastasis of hepatocellular carcinoma (HCC). Some long non-coding RNAs have been reported as modulators of stem-like properties in cancer cells. However, the role of LINC01013 in liver CSCs has not yet been clarified. Read More

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Anti-DLBCL efficacy of DCZ0825 in vitro and in vivo: involvement of the PI3K‒AKT‒mTOR/JNK pathway.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):575-583

Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, characterized by high heterogeneity. The poor outcome of a portion of patients who suffer relapsing or resistant to conventional treatment impels the development of novel agents for DLBCL. DCZ0825 is a novel compound derived from pterostilbene and osalmide, whose antitumor activities have drawn our attention. Read More

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Effects of CMYA1 overexpression on cardiac structure and function in mice.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):593-600

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

CMYA1 (cardiomyopathy-associated protein 1, also termed Xin) localizes to the intercalated disks (ICDs) of the myocardium and functions to maintain ICD structural integrity and support signal transduction among cardiomyocytes. Our previous study showed that CMYA1 overexpression impairs the function of gap junction intercellular communication processes. Successful model generation was verified based on PCR, western blot analysis, immunohistochemistry, and immunofluorescence analysis. Read More

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Neuritin promotes angiogenesis through inhibition of DLL4/Notch signaling pathway.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 31. Epub 2021 Mar 31.

Department of Biochemistry and Molecular Biology, Department of Basic Medical Sciences, School of Medicine, Shihezi University, Shihezi 832000, China.

Neuritin is a member of the neurotrophic factor family, which plays an important role in the promotion and development of the nervous system. Neuritin is also involved in angiogenesis. Neuritin was recently found to be a negative regulatory factor of the Notch 1 signaling pathway. Read More

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Liver kinase B1 attenuates liver ischemia/reperfusion injury via inhibiting the NLRP3 inflammasome.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):601-611

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China.

Liver ischemia/reperfusion injury (IRI), a serious inflammatory response driven by innate immunity, occurs in liver surgeries such as liver resection and liver transplantation, leading to liver dysfunction, liver failure, and even rejection after transplantation. Liver kinase B1 (LKB1) plays a pivotal anti-inflammatory role in IRI. One of the most important factors involved in liver IRI is the aberrant activation of the nucleotide binding oligomerization domain like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome in Kupffer cells. Read More

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STAM2 knockdown inhibits proliferation, migration, and invasion by affecting the JAK2/STAT3 signaling pathway in gastric cancer.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 29. Epub 2021 Mar 29.

Clinical Medical College of Yangzhou University, Northern Jiangsu Province Hospital, General Surgery Institute of Yangzhou, Yangzhou University, Yangzhou 225001, China.

Signal transducing adaptor molecule 2 (STAM2) is a phosphotyrosine protein, which regulates receptor signaling and trafficking of mammalian cells. However, its role in gastric cancer (GC) remains undiscovered. In this study, we aimed to investigate the functions of STAM2 in GC. Read More

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PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):584-592

Department of Clinical Laboratory, SSL Central Hospital of Dongguan City, The Third People's Hospital of Dongguan City, Dongguan 523326, China.

Oxaliplatin (OXA) resistance limits the efficiency of treatment for hepatocellular carcinoma (HCC). Studies have shown that the PDZ-binding kinase (PBK) plays important roles in tumors. However, the role of PBK in HCC is still a problem. Read More

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Novel application of bergapten and quercetin with anti-bacterial, osteogenesis-potentiating, and anti-inflammation tri-effects.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 27. Epub 2021 Mar 27.

Department of Oral and Maxillo-facial Implantology, Shanghai Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.

The bacteria-mediated inflammatory conditions adversely affect the osseointegration process of endosseous implants, which can even lead to implant malfunction or failure. Local drug delivery has been designed to exert anti-inflammatory and antibacterial activities, but whether this strategy has an effect on the compromised osseointegration under inflammation has rarely been studied. The present study focused on the osteoinductive efficacy of two known phytoestrogens (bergapten (BP) and quercetin (QE)) on implant sites under multiple bacteria-infected conditions in situ. Read More

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A modified pCas/pTargetF system for CRISPR-Cas9-assisted genome editing in Escherichia coli.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):620-627

Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, China.

The clustered regularly interspaced short palindromic repeats (CRISPR)-associated nuclease 9 (Cas9)-based genome editing tool pCas/pTargetF system that we established previously has been widely used in Escherichia coli MG1655. However, this system failed to manipulate the genome of E. coli BL21(DE3), owing to the potential higher leaky transcription of the gRNA-pMB1 specific to pTargetF in this strain. Read More

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CCL26 is upregulated by nab-paclitaxel in pancreatic cancer-associated fibroblasts and promotes PDAC invasiveness through activation of the PI3K/AKT/mTOR pathway.

Acta Biochim Biophys Sin (Shanghai) 2021 Apr;53(5):612-619

Department of Cardiothoracic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou 213000, China.

Recently, the combined use of FOLFIRINOX (leucovorin and fluorouracil plus irinotecan and oxaliplatin) and gemcitabine plus nab-paclitaxel has significantly improved the prognosis of patients with pancreatic cancer. However, there is still a high proportion of patients who develop metastatic pancreatic cancer in the course of chemotherapy or within a short period after chemotherapy. Previous reports have shown that chemotherapy-driven cytokine storms or the direct effects of certain chemotherapeutics on stromal and/or immune cells collectively change the microenvironment of the primary tumor, thus indirectly promoting metastasis. Read More

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Extending the L1 region in canonical double-stranded RNA-binding domains impairs their functions.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar;53(4):463-471

Department of Zoology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.

A large number of proteins involved in RNA metabolism possess a double-stranded RNA-binding domain (dsRBD), whose sequence variations and functional versatilities are still being recognized. All dsRBDs have a similar structural fold: α1-L1-β1-L2-β2-L3-β3-L4-α2 (α represents an α-helix, β a β-sheet, and L a loop conformation between the well-defined secondary structures). Our recent work revealed that the dsRBD in Drosha, which is involved in animal microRNA (miRNA) biogenesis, differs from other dsRBDs by containing a short insertion in its L1 region and that this insertion is important for Drosha function. Read More

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A novel ITAM-containing immunoglobulin superfamily receptor involved in lamprey VLRB₊ lymphocyte immune response.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 20. Epub 2021 Mar 20.

Lamprey Research Center, College of Life Science, Liaoning Normal University, Dalian 116081, China.

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Transfer of HBV genomes to bone marrow using adenovirus vectors leads to alteration of the hematopoietic status in mice.

Acta Biochim Biophys Sin (Shanghai) 2021 Mar 19. Epub 2021 Mar 19.

Clinical Laboratory, First Affiliated Hospital, University of South China, Hengyang 421001, China.

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