655,815 results match your criteria Acta Astronomica[Journal]


Role of Ancillary Techniques in Fluid Cytology.

Acta Cytol 2019 Apr 24:1-11. Epub 2019 Apr 24.

Hospital of the University of Pennsylvania, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

The cytologic evaluation of serous effusions may be challenging for a number of reasons. Distinction of benign, reactive conditions from malignancy represents the main focus when examining these specimens. The morphologic diagnosis of malignancy may be difficult due to the relative paucity of abnormal cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496568DOI Listing

Hip-fracture osteosynthesis training: exploring learning curves and setting proficiency standards.

Acta Orthop 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Copenhagen Academy for Medical Education and Simulation.

Background and purpose - Orthopedic surgeons must be able to perform internal fixation of proximal femoral fractures early in their career, but inexperienced trainees prolong surgery and cause increased reoperation rates. Simulation-based virtual reality (VR) training has been proposed to overcome the initial steep part of the learning curve but it is unknown how much simulation training is necessary before trainees can progress to supervised surgery on patients. We determined characteristics of learning curves for novices and experts and a pass/fail mastery-learning standard for junior trainees was established. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17453674.2019.1607111DOI Listing

Obesity related changes in cardiac structure and function: role of blood pressure and metabolic abnormalities.

Acta Cardiol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Dipartimento PROMISE , University of Palermo, School of Medicine , Palermo , ltaly.

Background: It has been reported that changes in cardiac structure and ventricular function associated with obesity have to be attributable to hemodynamic and non-hemodynamic alterations. Accordingly, the aim of this was to evaluate left ventricular hypertrophy (LVH) prevalence and its effect on left ventricular systolic and diastolic function in a cohort of obese patients.

Materials And Methods: LV internal diameter (LVID), left ventricular mass (LVM) and LVM/height(LVMI), relative wall thickness (RWT), LV ejection fraction (LVEF), E/A ratio, isovolumic relaxation time, deceleration time of E velocity by echocardiography and pulsed-wave Doppler and total circulating adiponectin (ADPN) by radioimmunoassay were measured in 319 obese subjects with and without LVH. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/00015385.2019.1598638DOI Listing

Marker-based versus model-based radiostereometric analysis of total knee arthroplasty migration: a reanalysis with comparable mean outcomes despite distinct types of measurement error.

Acta Orthop 2019 Apr 24:1-9. Epub 2019 Apr 24.

a Department of Orthopaedics , Leiden University Medical Center , Leiden , the Netherlands.

Background and purpose - Pooling data of studies evaluating total knee arthroplasty migration using radiostereometric analysis (RSA) may be compromised when the RSA method used would influence estimated differences between groups. We therefore reanalyzed a marker-based RSA study with model-based RSA to assess possible limitations of each RSA method, including insert micromotions in modular TKA and their effect on estimated group differences. Patients and methods - All patients had received a cemented Triathlon implant (Stryker, Mahwah, NJ, USA) with either an all-polyethylene (n = 29) or a metal-backed (n = 28) tibial component. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17453674.2019.1605692DOI Listing

The Labor Progression Study (LaPS): The use of oxytocin augmentation during labor following Zhang's guideline and the WHO partograph in a cluster randomized trial.

Acta Obstet Gynecol Scand 2019 Apr 24. Epub 2019 Apr 24.

Department of Nursing and Health Promotion, Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, Oslo, Norway.

Introduction: This study aims to investigate the use of oxytocin augmentation during labor in nulliparous women following Zhang's guideline or the WHO partograph.

Material And Methods: This is a secondary analysis of a cluster randomized controlled trial in 14 birth care units in Norway, randomly assigned to either the intervention group, which followed Zhang's guideline, or to the control group, which followed the WHO partograph, for labor progression. The participants were nulliparous women who had a singleton full-term fetus in a cephalic presentation and spontaneous onset of labor, denoted as group 1 in the Ten Group Classification System. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aogs.13629DOI Listing
April 2019
1 Read

Secondary prevention after stroke/transient ischemic attack, a randomized audit&feedback trial.

Acta Neurol Scand 2019 Apr 24. Epub 2019 Apr 24.

Karolinska Institutet Stroke Research Network at Södersjukhuset, Sweden.

Objectives: The clinical benefits of use of secondary preventive pharmacotherapy in ischemic stroke/TIA have been previously demonstrated. A potential target for facilitating use of recommended medication is primary care physicians. Therefore, we carried out an audit&feedback intervention aimed at primary care centers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ane.13109DOI Listing

Sunbed Use Increases Cutaneous Squamous Cell Carcinoma Risk in Women: A Large-scale, Prospective Study in Sweden.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Skåne University Hospital, Lasarettsgatan 15, SE-22241 Lund, Sweden.

The incidence of cutaneous squamous cell carcinoma has increased rapidly in Sweden in the past decades. Here, we present a prospective study of the Melanoma in Southern Sweden (MISS)-cohort, with 29,460 participating women in southern Sweden that investigates the risk factors for cutaneous squamous cell carcinoma. Data on the host and skin cancer risk factors were collected through questionnaires and then matched with the National Cancer Registry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3198DOI Listing

Systemic Lupus Erythematosus with Familial Mediterranean Fever: Case Report and Review of Literature.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Shiga University of Medical Science, 520-2192 Setatsukinowa, Otsu, Shiga, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3197DOI Listing

IL-17A Inhibitor Switching - Efficacy of Ixekizumab Following Secukinumab Failure. A Single-Center Experience.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Rabin Medical Center - Beilinson Hospital, 4941492 Petach, Israel.

Interleukin-17A inhibitors are a promising alternative to tumor necrosis factor-α inhibitors for the treatment of psoriasis. In-class switch has been hardly investigated for interleukin-17A inhibitors. We report the experience (2017-2018) of a tertiary medical center with interleukin-17A-inhibitor switch in patients with moderate-to-severe psoriasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3200DOI Listing

Vitiligo Repigmentation with Melanoma Progression During Pembrolizumab Treatment.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, University of Bourgogne-Franche Comté, FR-25000 Besançon, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3199DOI Listing

Therapeutic Efficacy of Etretinate on Cutaneous-type Adult T-cell Leukemia-Lymphoma.

Acta Derm Venereol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, Imamura General Hospital, 8900064 Kagoshima, Japan.

Cutaneous-type adult T-cell leukemia-lymphoma is treated with antiviral or skin-directed therapy. Medications that are used to treat skin lesions of cutaneous T-cell lymphomas are also used for the cutaneous-type adult T-cell leukemia-lymphoma. Etretinate, a synthetic retinoid, has been used for treating cutaneous T-cell lymphomas; however, its clinical effectiveness for the treatment of cutaneous-type adult T-cell leukemia-lymphoma has not been fully studied. Read More

View Article

Download full-text PDF

Source
http://www.medicaljournals.se/acta/content/abstract/10.2340/
Publisher Site
http://dx.doi.org/10.2340/00015555-3196DOI Listing
April 2019
5 Reads

Comparison of 3D conformal radiation therapy and intensity-modulated radiation therapy in patients with endometrial cancer: efficacy, safety and prognostic analysis.

Acta Oncol 2019 Apr 24:1-8. Epub 2019 Apr 24.

a Department of Radiation Oncology , Tenon University Hospital, Hôpitaux Universitaires Est Parisien, Sorbonne University Medical Faculty , Paris , France.

Introduction: Adjuvant whole-pelvic radiation therapy (WPRT) improves locoregional control for high-intermediate stages I-III endometrial cancer patients. Intensity modulated radiation therapy (IMRT) tends to replace the standard 3D conformal radiation therapy (3DCRT) technique used in trials.

Material And Methods: Consecutive patients with stages I-IIIc endometrial cancer treated between 2008 and 2014 in our department with post-operative 3DCRT or IMRT WPRT were studied retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/0284186X.2019.1599136DOI Listing

TOXview: a novel graphical presentation of cancer treatment toxicity profiles.

Acta Oncol 2019 Apr 24:1-11. Epub 2019 Apr 24.

a Department of Medical Oncology, Cancer Centre Amsterdam , Amsterdam UMC, University of Amsterdam , Amsterdam , the Netherlands.

Background: Toxicity profiles play a crucial role in the choice between specific palliative chemotherapy regimens. To optimize the quality of life for cancer patients, patients should be adequately informed about potential toxicities before undergoing chemotherapy. Therefore, we constructed TOXviews, a novel graphical presentation and overview of toxicity profiles to improve information provision about adverse events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/0284186X.2019.1601256DOI Listing

A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes.

Acta Ophthalmol 2019 Apr 24. Epub 2019 Apr 24.

Department of Ophthalmology, Medical Faculty Carl Gustav Carus, Technische Universität, Dresden, Germany.

Background: To test the ability of the newly calculated Dresden biomechanical glaucoma factor (DBGF) based on dynamic corneal response (DCR) deformation and corneal thickness parameters, to discriminate between healthy and normal pressure glaucoma (NPG) eyes.

Methods: Seventy healthy and 70 NPG patients of Caucasian origin were recruited for this multicentre cross-sectional pilot study, which included both eyes for analysis. Logistic regression analysis with generalized estimating equation (GEE) models to account for correlations between eyes and a threefold cross-validation were performed to determine the optimal combination of Corvis ST parameters in order to separate normal from NPG eyes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aos.14115DOI Listing

Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism.

Acta Ophthalmol 2019 Apr 24. Epub 2019 Apr 24.

Department of Ophthalmology, University of Southern California, Los Angeles, California, USA.

Purpose: To test the hypothesis that visual field (VF) loss is associated with decreased retinal blood flow, oxygen delivery and metabolism, and with increased retinal oxygen extraction fraction (OEF) in glaucomatous individuals.

Methods: Glaucomatous subjects underwent automated perimetry, dual wavelength scanning laser ophthalmoscopy and Doppler optical coherence tomography imaging in order to measure mean deviation, central retinal arterial and venous diameter equivalents (CRAE and CRVE), oxygen saturation levels and total retinal blood flow (TRBF), respectively. Retinal oxygen delivery, metabolism and extraction fraction were derived from measurements of oxygen saturation and blood flow. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aos.14120DOI Listing

Use of intraoperative anterior segment optical coherence tomography for Bowman layer transplantation.

Acta Ophthalmol 2019 Apr 23. Epub 2019 Apr 23.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aos.14104DOI Listing

IL-6 counteracts the inhibitory effect of IL-4 on osteogenic differentiation of human adipose stem cells.

J Cell Physiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Oral Cell Biology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

Fracture repair is characterized by cytokine production and hypoxia. To better predict cytokine modulation of mesenchymal stem cell (MSC)-aided bone healing, we investigated whether interleukin 4 (IL-4), IL-6, and their combination, affect osteogenic differentiation, vascular endothelial growth factor (VEGF) production, and/or mammalian target of rapamycin complex 1 (mTORC1) activation by MSCs under normoxia or hypoxia. Human adipose stem cells (hASCs) were cultured with IL-4, IL-6, or their combination for 3 days under normoxia (20% O ) or hypoxia (1% O ), followed by 11 days without cytokines under normoxia or hypoxia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jcp.28652DOI Listing

Dental injuries in relation to general anaesthesia-A retrospective study.

Acta Anaesthesiol Scand 2019 Apr 23. Epub 2019 Apr 23.

Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Dental injuries may occur during general anaesthesia, especially during airway management. The aim of this study was to describe cases of dental injury related to general anaesthesia, focusing on the type and extent of the injuries as well as the timing of recognition.

Method: We reviewed the nationwide electronic database available at the Danish Patient Compensation Association and scrutinized all claims classified as possible dental injuries in relation to general anaesthesia between 2007 and 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/aas.13378DOI Listing

Fluorescent C-NanoDots for rapid detection of BRCA1, CFTR and MRP3 gene mutations.

Mikrochim Acta 2019 Apr 23;186(5):293. Epub 2019 Apr 23.

Analytical Chemistry Department, Institute for Advanced Research in Chemical Sciences (IAdChem), Universidad Autónoma de Madrid, 28049, Madrid, Spain.

The authors report on a fluorometric method for the rapid detection of BRCA1, CFRT and MRP3 gene mutations. These are associated with breast cancer, cystic fibrosis and autoimmune hepatitis diseases, respectively. Carbon nanodots with blue fluorescence (with excitation/emission maxima at 340/440 nm) were synthesized and characterized, and their interactions with DNA were investigated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3386-9DOI Listing

Brain biopsy in suspected non-neoplastic neurological disease.

Acta Neurochir (Wien) 2019 Apr 23. Epub 2019 Apr 23.

Neuropathology Unit, Hospital de Santo Antonio, Centro Hospitalar e Universitario do Porto, Porto, Portugal.

Brain biopsy has a well-established role in the diagnosis of CNS neoplasia. Nevertheless, despite being essential for the diagnosis of some benign neurological diseases, little consensus exists regarding its indications for disease diagnosis and patient orientation. Our aim was to assess brain biopsy diagnostic yield in patients with neurological deterioration of unknown etiology, to identify the clinical characteristics associated with an increased likelihood of achieving a diagnostic biopsy as well as the characteristics linked to a particular diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00701-019-03910-8DOI Listing

Immunoassay for pathogenic bacteria using platinum nanoparticles and a hand-held hydrogen detector as transducer. Application to the detection of Escherichia coli O157:H7.

Mikrochim Acta 2019 Apr 23;186(5):296. Epub 2019 Apr 23.

Institute of Military Veterinary, Academy of Military Medical Sciences, Changchun, 130122, China.

An innovative approach is presented for portable and sensitive detection of pathogenic bacteria. A novel synthetic hybrid nanocomposite encapsulating platinum nanoparticles, as a highly efficient catalyst, catalyzes the hydrolysis of the ammonia-borane complex to generate hydrogen gas. The nanocomposites are used as a label for immunoassays. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3409-6DOI Listing

Nickel-iron layered double hydroxide nanostructures for micro solid phase extraction of nonsteroidal anti-inflammatory drugs, followed by quantitation by HPLC-UV.

Mikrochim Acta 2019 Apr 23;186(5):297. Epub 2019 Apr 23.

Department of Analytical Chemistry, Faculty of Chemistry, K.N. Toosi University of Technology, P.O. Box 16315-1618, Tehran, Postal Code 15418-49611, Iran.

Layered double hydroxides (LDHs) of nickel and iron were hydrothermally prepared by co-precipitation using urea hydrolysis. The Ni-Fe LDH nanostructures were characterized by X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, thermogravimetric and energy dispersive X-ray analysis. The LDHs are shown to be a viable sorbent for micro solid phase extraction by packed sorbent of the nonsteroidal anti-inflammatory drugs (NSAIDs) diclofenac, ibuprofen, mefenamic acid and naproxen from human urine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3419-4DOI Listing

A bifunctional metal organic framework of type Fe(III)-BTC for cascade (enzymatic and enzyme-mimicking) colorimetric determination of glucose.

Mikrochim Acta 2019 Apr 23;186(5):295. Epub 2019 Apr 23.

State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin, 541004, People's Republic of China.

A metal organic framework (MOF) of type Fe(III)-BTC (where BTC is 1,3,5-benzenetricarboxylic acid) was utilized to construct an integrated system for cascade colorimetric determination of glucose. The MOF performs a dual function in acting (a) as a peroxidase (POx) mimic, and (b) as a solid support for immobilization of glucose oxidase (GOx). The MOF was prepared by a one-pot method. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3416-7DOI Listing

Sensitive determination of nitrite by using an electrode modified with hierarchical three-dimensional tungsten disulfide and reduced graphene oxide aerogel.

Mikrochim Acta 2019 Apr 23;186(5):291. Epub 2019 Apr 23.

Key Laboratory of Crop Physiology, Ecology and Genetic Breeding, Ministry of Education, Institute of functional materials and agricultural applied chemistry, College of Science, Jiangxi Agricultural University, Nanchang, 330045, People's Republic of China.

Nanosheets of tungsten disulfide (WS) were used to improve the physicochemical properties of reduced graphene oxide aerogel (rGA). The nanosheets were directly integrated into 3D hybrid architecture of rGA by a solvothermal mixing method by which the WS sheets were assembled onto the conductive graphene network. WS with highly exfoliated and defect-rich structure made the WS/rGA composite possess plentiful active sites, and this enhanced the electrocatalytic capability of the composite. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3379-8DOI Listing
April 2019
2 Reads

Correction to: A review on nanomaterial-modified optical fiber sensors for gases, vapors and ions.

Mikrochim Acta 2019 Apr 23;186(5):292. Epub 2019 Apr 23.

Department of Applied Physics, Defence Institute of Advanced Technology, Girinagar, Pune, 411025, India.

The published version of this article, unfortunately, contains error. Corrections in Figs. 1, 3 and 5 were incorrectly carried out. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3383-zDOI Listing

A FRET-based fluorescent probe for hydrogen peroxide based on the use of carbon quantum dots conjugated to gold nanoclusters.

Mikrochim Acta 2019 Apr 23;186(5):294. Epub 2019 Apr 23.

The Education Ministry Key Laboratory of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, College of Chemistry and Materials Science, Shanghai Normal University, 100 Guilin Road, Shanghai, 200234, China.

In the Fenton reaction, ferrous ion acts as a catalyst and reacts with hydrogen peroxide (HO) to produce hydroxy radicals (·OH) and hydroperoxy radicals (·OOH). Both have much stronger oxidization ability than HO. A fluorescent probe for HO is described here that was obtained by covalent conjugation of carbon quantum dots to gold nanoclusters (AuNCs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3398-5DOI Listing

A fluorometric assay for oxytetracycline based on the use of its europium(III) complex and aptamer-modified silver nanoparticles.

Mikrochim Acta 2019 Apr 23;186(5):290. Epub 2019 Apr 23.

Department of Chemistry, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, 91779-48974, Iran.

An ultrasensitive assay is described for the determination of oxytetracycline (OTC) at nanomolar levels. The method is using silver nanoparticles (AgNPs) that were first modified with OTC-binding aptamer and then exposed to the OTC-Eu(III) complex. The pink fluorescence of the OTC-Eu(III) complex on the AgNPs is almost completely quenched. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00604-019-3389-6DOI Listing

Exchange Transfusion and Cytarabine for Transient Abnormal Myelopoiesis in Hydrops Fetalis.

Acta Med Okayama 2019 Apr;73(2):181-188

Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56655DOI Listing

A Rare Case of Gastrojejunocutaneous Fistula after Percutaneous Endoscopic Gastrostomy.

Acta Med Okayama 2019 Apr;73(2):177-180

Department of Surgery, Okayama City Hosptial,Okayama 700-8557, Japan.

We report a rare case of fistulation to the jejunum after percutaneous endoscopic gastrostomy (PEG). An 85-year-old man with previous cerebral infarction and swallowing disturbance underwent PEG. Nine months later, he developed a high fever and discharge around the gastrostomy button. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56654DOI Listing

Successful Delivery after Abdominal Radical Trachelectomy, Using Transabdominal Cerclage in Early Pregnancy.

Acta Med Okayama 2019 Apr;73(2):173-176

Departments of Obstetrics and Gynecology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

Radical trachelectomy (RT) is a fertility-sparing surgery for cervical cancer. Postoperative pregnancies have a high risk of abortion and prematurity. To prevent this, a procedure involving transabdominal cerclage (TAC) was devised for shortened cervical canals post-RT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56653DOI Listing
April 2019
1 Read

Salvage Haploidentical Transplantation Using Low-dose ATG for Early Disease Relapse after First Allogeneic Transplantation: A Retrospective Single-center Review.

Acta Med Okayama 2019 Apr;73(2):161-171

Department of Hematology and Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceuticals Sciences, Okayama 700-8558, Japan.

Second allogeneic stem cell transplantation (allo-SCT) is a potentially curative therapy for patients who relapse after first allo-SCT. Human leukocyte antigen (HLA)-haploidentical related donors provide the broad opportunity to conduct second SCT at the appropriate time, but the efficacy of second SCT from haploidentical donors after relapse has not been established. We retrospectively analyzed the records of 33 patients who underwent second SCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56652DOI Listing

Clinical Characteristics of Severe Refractory Asthma Associated with the Effectiveness of Bronchial Thermoplasty.

Acta Med Okayama 2019 Apr;73(2):155-160

Department of Respiratory Medicine, Okayama Medical Center, Okayama 701-1192,

We investigated the clinical characteristics of refractory asthma associated with the effectiveness of bronchial thermoplasty (BT). We retrospectively evaluated data from 10 patients who underwent BT between June 2016 and December 2017 at Okayama Medical Center. The following were measured before and 6 months post-BT: forced expiratory volume in 1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56651DOI Listing
April 2019
1 Read

Prolonged Tachycardia with Higher Heart Rate Is Associated with Higher ICU and In-hospital Mortality.

Acta Med Okayama 2019 Apr;73(2):147-153

Department of Anesthesiology and Resuscitology, Okayama University Hospital, Okayama 700-8558,

Tachycardia is common in intensive care units (ICUs). It is unknown whether tachycardia or prolonged tachycardia affects patient outcomes. We investigated the association between tachycardia and mortality in critically ill patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56650DOI Listing

Collagen XVIII Deposition in the Basement Membrane Zone beneath the Newly Forming Epidermis during Wound Healing in Mice.

Acta Med Okayama 2019 Apr;73(2):135-146

Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama 700-8558, Japan.

The basement membrane (BM) is composed of various extracellular molecules and regulates tissue regeneration and maintenance. Here, we demonstrate that collagen XVIII was spatiotemporally expressed in the BM during skin wound healing in a mouse excisional wound-splinting model. Re-epithelialization was detected at days 3 and 6 post-wounding. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56649DOI Listing

Thyroid Function Decline and Diet in Female High School Long-distance Runners.

Acta Med Okayama 2019 Apr;73(2):127-133

Graduate School of Health Sciences, Okayama University, Okayama 700-8558, Japan.

We aimed to clarify the state of thyroid function in female high school long-distance runners. We evaluated the associations between thyroid function and menstrual condition, bone mineral density (BMD), nutritious status, and body composition. The subjects' height and weight were measured, along with fat percentage, fat mass, muscle mass, and BMD with dual-energy X-ray absorptiometry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56648DOI Listing
April 2019
1 Read

Unintentional Injury Deaths among Children: A Descriptive Study Using Medico-legal Documents in Okayama Prefecture, Japan (2001-2015).

Acta Med Okayama 2019 Apr;73(2):117-125

Department of Legal Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

According to the World Health Organization's World Report, approx. 950,000 children and young people < 18 years old die from an injury each year, and unintentional injury deaths account for a large portion of these cases. Here we used medico-legal documents to epidemiologically analyze the cases of unintentional injury deaths among children < 5 years old in Okayama Prefecture, Japan from 2001 to 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56647DOI Listing

Clinicopathological Features and Outcomes of Endoscopic Submucosal Dissection for Superficial Cancer of the Pharynx.

Acta Med Okayama 2019 Apr;73(2):109-115

Department of Gastroenterology and Hepatology,Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558,

The efficacy and safety of endoscopic submucosal dissection (ESD) for superficial cancer of the pharynx are still unclear. To identify clinicopathological features of superficial pharyngeal cancer, and the efficacy and safety of ESD, we retrospectively assessed 70 pharyngeal cancers in 59 patients who underwent ESD. Of these patients, 61. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56646DOI Listing

Factors Affecting the Absorption of Midazolam to the Extracorporeal Membrane Oxygenation Circuit.

Acta Med Okayama 2019 Apr;73(2):101-107

Department of Emergency and Critical Care and Disaster Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.

Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56645DOI Listing
April 2019
1 Read

Effect of Self-perceived Fatigue on Balance and Functional Mobility in Middle-Aged Obese Women.

Acta Med Okayama 2019 Apr;73(2):95-100

Department of Sports Medicine, Suleyman Demirel University, Medicine Faculty, Sports Medicine Department, Isparta 32200,

The aim of this study was to examine effect of fatigue levels on functional mobility and balance in middle-aged obese females. The study included 98 healthy females aged 40-60 years with BMI ≥ 30 kg/m2. Self-perceived fatigue was evaluated with a self-administered questionnaire, the Checklist of Individual Strength in Turkish (CIS-T), on which 62. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18926/AMO/56644DOI Listing

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway.

Acta Pharmacol Sin 2019 Apr 23. Epub 2019 Apr 23.

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.

Microglia, the brain-resident macrophage, is known as the innate immune cell type in the central nervous system. Microglia is also the major cellular component of tumor mass of gliomas that plays a key role in glioma development. Mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2) frequently occur in gliomas, which leads to accumulation of oncometabolic product 2-hydroxyglutarate (2HG). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41401-019-0225-9DOI Listing

Publisher Correction: Inflammation-activated CXCL16 pathway contributes to tubulointerstitial injury in mouse diabetic nephropathy.

Acta Pharmacol Sin 2019 Apr 23. Epub 2019 Apr 23.

Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

The REFERENCES 1-35 are wrong because of the error in the process of typesetting. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41401-019-0226-8DOI Listing

A novel gemcitabine derivative-loaded liposome with great pancreas-targeting ability.

Acta Pharmacol Sin 2019 Apr 23. Epub 2019 Apr 23.

School of Pharmacy, Chengdu Medical College, Chengdu 610500, China.

Gemcitabine (Gem) is a standard first-line treatment for pancreatic cancer (PC). However, its chemotherapeutic efficacy is hampered by various limitations such as short half-life, metabolic inactivation, and lack of tumor localizing. We previously synthesized a lipophilic Gem derivative (Gem formyl hexadecyl ester, GemC16) that exhibited improved antitumor activity in vitro. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41401-019-0227-7DOI Listing

Increased mast cell number is associated with a decrease in beta-cell mass and regeneration in type 2 diabetic rats.

Acta Histochem 2019 Apr 20. Epub 2019 Apr 20.

Department of Medical Histology and Cell Biology, Faculty of Medicine, Mansoura University, Egypt; Department of Basic Medical Sciences, Unit of Anatomy, Unaizah College of Medicine, Qassim University, Al Qassim, Saudi Arabia.

The role of mast cells (MCs) in type 2 diabetes (T2D) is not thoroughly studied as much as in T1D. Therefore in the current study we investigated correlation between these cells and various parameters of islets of Langerhans (IOL) in rats which were equally divided (n = 40) into; control and diabetic groups. We detected a significantly increased (p < 0. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00651281193001
Publisher Site
http://dx.doi.org/10.1016/j.acthis.2019.04.009DOI Listing
April 2019
1 Read

Characteristics of apparently healthy individuals with a very low C-reactive protein.

Clin Chim Acta 2019 Apr 20. Epub 2019 Apr 20.

Department of Internal Medicine "C", "D" and "E", Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 6423906, Israel.

Background: The importance of the inflammatory processes and C-reactive protein (CRP) evaluation was observed. Only few studies used cut-off value <1 mg/L. We sought to evaluate the association between very low CRP (vlCRP) and health status, to describe the repetition of vlCRP and to identify predictors for repetition. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2019.04.073DOI Listing

Small but non-negligible discrepancy between subgroup and single CKD-EPI equation to calculate the estimated glomerular filtration rate.

Authors:
Tae-Dong Jeong

Clin Chim Acta 2019 Apr 20. Epub 2019 Apr 20.

Department of Laboratory Medicine, College of Medicine, Ewha Womans University, Seoul, Republic of Korea. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2019.04.071DOI Listing

Analysis of serum Haptoglobin using glycoproteomics and lectin immunoassay in liver diseases in Hepatitis B virus infection.

Clin Chim Acta 2019 Apr 20. Epub 2019 Apr 20.

Transfusion Transmitted Diseases Department, National Institute of Immunohaematology (ICMR), 13th Floor, New Multi-storeyed Bldg, KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India. Electronic address:

Background: Hepatocellular carcinoma (HCC) due to Hepatitis B viral (HBV) infection is major cause in Asia-Pacific countries. Its early detection is of paramount importance using a marker having both sensitivity and specificity. The present study promises diagnostic and prognostic markers by the identification of site specific glycoforms on Haptoglobin (Hp) using LC-MS/MS and lectin ELISA in liver diseased conditions in HBV infection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cca.2019.04.072DOI Listing

Trismus and oral haematoma, a rare presentation of tetanus.

Acta Otorrinolaringol Esp 2019 Apr 20. Epub 2019 Apr 20.

Otorhinolaryngology - Head and Neck Surgery Department, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña, Galicia, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.otorri.2019.01.004DOI Listing

The Role of Ancillary Techniques in Pulmonary Cytopathology.

Acta Cytol 2019 Apr 23:1-9. Epub 2019 Apr 23.

Department of Pathology, New York University School of Medicine, New York, New York, USA,

Ancillary techniques play an essential role in pulmonary cytopathology. Immunoperoxidase and special stains are by far the most common ancillary techniques used in cytopathology; however, the role of molecular diagnosis is growing, especially in the fields of pulmonary oncology and infectious disease. In this article, we review the uses of ancillary techniques in lung tumor diagnosis, lung tumor classification, predictive marker determination, primary versus metastasis differential diagnosis, and infectious organism detection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000498889DOI Listing

The Assessment of Serum Drug Levels to Diagnose Non-Adherence in Stable Chronic Heart Failure Patients.

Acta Medica (Hradec Kralove) 2019 Apr 23. Epub 2019 Apr 23.

Department of Internal Medicine, Faculty of Medicine in Hradec Králové, Charles University, Hradec Králové, Czech Republic.

Background: The aim of our study was to evaluate the prevalence of drug non-adherence in stable chronic heart failure (CHF) patients using serum drug levels (SDL) assessment.

Methods: CHF patients were prospectively enrolled during scheduled outpatient visit. Except standard procedures an unanticipated blood sampling for the SDL assessment was obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14712/18059694.2019.46DOI Listing
  • Page 1 of 13117