10,361 results match your criteria Acta Anaesthesiologica Scandinavica[Journal]


Vasoactive and/or inotropic drugs in initial resuscitation of burn injuries: A systematic review.

Acta Anaesthesiol Scand 2022 May 18. Epub 2022 May 18.

Specialised Health Care services, Quality and Clinical Pathways, Norwegian Directorate of Health, P. O. Box 220, Skøyen, Oslo, Norway.

Background: According to current guidelines initial burn resuscitation should be performed with fluids alone. The aims of the study were to review the frequency of use of vasoactive and/or inotropic drugs in initial burn resuscitation, and assess benefits and harms of adding such drugs to fluids.

Methods: A systematic literature search was conducted in PubMed, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, UpToDate, and SveMed+ through 3 December 2021. Read More

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The use of melatonin in Danish intensive care departments - a nationwide observational study.

Acta Anaesthesiol Scand 2022 May 18. Epub 2022 May 18.

Department of Anaesthesia and Intensive Care, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Background: Melatonin is widely employed as a hypnotic in various patient groups. In intensive care patients, melatonin seems to be increasingly used due to potential clinical effects and a favorable safety profile.

Objectives: We aimed to investigate the extend of usage and clinical practice of melatonin therapy in intensive care departments in Denmark. Read More

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Agents intervening against delirium in the intensive care unit (AID-ICU) trial-protocol for a secondary Bayesian analysis.

Acta Anaesthesiol Scand 2022 May 17. Epub 2022 May 17.

Collaboration for Research in Intensive Care (CRIC), Copenhagen, Denmark.

Background: Delirium is highly prevalent in the intensive care unit (ICU) and associated with high morbidity and mortality. The antipsychotic haloperidol is the most frequently used agent to treat delirium although this is not supported by solid evidence. The AID-ICU trial investigates the effects of haloperidol versus placebo for the treatment of delirium in adult ICU patients. Read More

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Chronic critical illness - What is it and what can be done about it?

Acta Anaesthesiol Scand 2022 May 1. Epub 2022 May 1.

Department of Medical Intensive Care, Hadassah Hospital and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

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Kinetics of 5% and 20% albumin: A controlled crossover trial in volunteers.

Acta Anaesthesiol Scand 2022 May 1. Epub 2022 May 1.

Research Unit, Södertälje Hospital, Södertälje, Sweden, and Karolinska Institutet at Danderyds Hospital (KIDS), Danderyd, Sweden.

Background: Albumin for intravenous infusion is marketed in two concentrations, 20% and 5%, but how they compare with regard to plasma volume expansion over time is unclear.

Methods: In a prospective crossover study, 12 volunteers received 3 ml kg of 20% albumin and, on another occasion, 12 ml kg of 5% albumin over 30 min. Hence, equivalent amounts of albumin were given. Read More

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Quantitative pupillometry in comatose out-of-hospital cardiac arrest patients: a post-hoc analysis of the TTH48 trial.

Acta Anaesthesiol Scand 2022 Apr 30. Epub 2022 Apr 30.

Research Center for Emergency Medicine, Emergency Department, Aarhus University Hospital and Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Quantitative pupillometry is an objective method to examine pupil reaction and subsequently grade the response on a neurological pupil index (NPi) scale from 0 to 5. The aim of the present sub-study was to explore the long-term prognostic value of NPi in comatose out-of-hospital cardiac arrest patients undergoing targeted temperature management (TTM).

Methods: This planned sub-study of the "Targeted temperature management for 48 vs. Read More

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Acetate- versus lactate-buffered crystalloid solutions: A systematic review with meta-analysis and trial sequential analysis.

Acta Anaesthesiol Scand 2022 Apr 30. Epub 2022 Apr 30.

Department of Intensive Care 4131, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Objective: There is a widespread use of buffered crystalloid solutions in clinical practice. However, guidelines do not distinguish between specific types of buffered solutions and clinical equipoise exists. We aimed to assess the desirable and undesirable effects of acetate- versus lactate-buffered solutions in hospitalised patients. Read More

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Serum concentration of oral midazolam as pediatric preanesthetic medication and factors related to the sedation level.

Acta Anaesthesiol Scand 2022 Apr 30. Epub 2022 Apr 30.

Department of Anesthesiology, School of Medicine, Kitasato, Kanagawa, Japan.

Background: Preanesthetic medication is important to eliminate surgical anxiety in pediatric patients and facilitate their smooth transfer to the operating room. Midazolam is the most commonly used preanesthetic medication. However, it has been reported that the sedative effect varies from patient to patient. Read More

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Erratum.

Authors:

Acta Anaesthesiol Scand 2022 May;66(5):655

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Effects of mandibular distraction osteogenesis on anesthetic implications in children with hemifacial microsomia.

Acta Anaesthesiol Scand 2022 Apr 13. Epub 2022 Apr 13.

Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Hemifacial microsomia (HFM) is a congenital craniofacial malformation, and its features include hypoplasia and asymmetry in skeletal tissue and soft tissue. These features are usually associated with a difficult airway. Mandibular distraction osteogenesis can achieve mandibular advancement, but its effect on the subsequent laryngoscopic views has not been adequately documented. Read More

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Pupil response to painful stimuli during inhalation anaesthesia without opioids in children.

Acta Anaesthesiol Scand 2022 Apr 11. Epub 2022 Apr 11.

Department of Anaesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: Pupil dilation reflex measured by a pupillometer is known to be a useful parameter for assessing the response to perioperative noxious stimuli. In children, pupillometer can reflect changes after painful stimuli during anaesthesia or guide anaesthesia to reduce opioid consumption. However, to date, there are no data regarding pupil response during inhalation anaesthesia with analgesia by intravenous acetaminophen in children. Read More

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Senicapoc treatment in COVID-19 patients with severe respiratory insufficiency-A randomized, open-label, phase II trial.

Acta Anaesthesiol Scand 2022 Apr 11. Epub 2022 Apr 11.

Department of Biomedicine, Pulmonary and Cardiovascular Pharmacology, Aarhus University, Aarhus, Denmark.

Background: The aim of the current study was to determine if treatment with senicapoc, improves the PaO /FiO ratio in patients with COVID-19 and severe respiratory insufficiency.

Methods: Investigator-initiated, randomized, open-label, phase II trial in four intensive care units (ICU) in Denmark. We included patients aged ≥18 years and admitted to an ICU with severe respiratory insufficiency due to COVID-19. Read More

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Patient characteristics, management and outcomes in a Nordic subset of the "large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study.

Acta Anaesthesiol Scand 2022 Apr 10. Epub 2022 Apr 10.

School of Medicine, National University of Ireland Galway and Dept of Anaesthesia and Intensive Care Medicine, Galway University Hospitals, Galway, Ireland.

Background: The "Large observational study to understand the global impact of severe acute respiratory failure" (LUNG SAFE) study described the worldwide epidemiology and management of patients with acute hypoxaemic respiratory failure (AHRF). Here, we present the Nordic subset of data from the LUNG SAFE cohort.

Methods: We extracted LUNG SAFE data for adults fulfilling criteria for AHRF in intensive care units (ICU) in Denmark, Norway and Sweden, including demographics, co-morbidities, clinical assessment and management characteristics, 90-day survival and length-of-stay (LOS). Read More

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Fluid-responsiveness, blood volume and perfusion in preoperative haemodynamic optimisation of hip fracture patients; a prospective observational study.

Acta Anaesthesiol Scand 2022 Apr 9. Epub 2022 Apr 9.

Department of Anesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Preoperative resuscitation strategies in patients with hip fracture (HF) are lacking. We aimed to investigate fluid-responsiveness, peripheral perfusion index (PPI) and blood volume (BV)-status in patients with HF undergoing resuscitation in the preoperative phase.

Methods: In a prospective observational study, we evaluated preoperative fluid-responsiveness, indices of perfusion and BV before and after lumbar epidural analgesia in 50 patients with HF shortly after admittance. Read More

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Association of Sequential Organ Failure Assessment (SOFA) components with mortality.

Acta Anaesthesiol Scand 2022 Mar 30. Epub 2022 Mar 30.

Department of Anaesthesiology and Intensive Care, Kuopio University Hospital, Kuopio, Finland.

Background: Sequential Organ Failure Assessment (SOFA) is a practical method to describe and quantify the presence and severity of organ system dysfunctions and failures. Some proposals suggest that SOFA could be employed as an endpoint in trials. To justify this, all SOFA component scores should reflect organ dysfunctions of comparable severity. Read More

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Increased risk of ventilator-associated pneumonia in patients after cardiac arrest treated with mild therapeutic hypothermia.

Acta Anaesthesiol Scand 2022 Mar 26. Epub 2022 Mar 26.

Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Innsbruck, Austria.

Background: We aimed at investigating the incidence, characteristics and outcome of ventilator-associated pneumonia (VAP) in patients after cardiac arrest (CA) and its potential association with mild therapeutic hypothermia (MTH). We hypothesized, that MTH might increase the risk of VAP.

Methods: Prospective observational study including comatose adult patients after successful resuscitation from out-of-hospital or in-hospital CA with presumed cardiac cause admitted to ICU and treated with MTH at 33°C for 24 h or normothermia (NT) with treatment of fever ≥38°C by pharmacological means. Read More

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Conservative vs. liberal fluid therapy in septic shock - Protocol for secondary Bayesian analyses of the CLASSIC trial.

Acta Anaesthesiol Scand 2022 Mar 26. Epub 2022 Mar 26.

Department of Intensive Care, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: Clinical equipoise exists regarding intravenous (IV) fluid volumes in sepsis. The Conservative vs. Liberal Approach to fluid therapy of Septic Shock in Intensive Care (CLASSIC) trial investigates the effect of restricted vs. Read More

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Cerebral oxygen desaturation events during and functional outcomes after prehospital anaesthesia: A prospective pilot study.

Acta Anaesthesiol Scand 2022 Mar 26. Epub 2022 Mar 26.

FinnHEMS Research and Development Unit, Vantaa, Finland.

Background: During prehospital anaesthesia, oxygen delivery to the brain might be inadequate to match the oxygen consumption, with unknown long-term functional outcomes. We aimed to evaluate the feasibility of monitoring cerebral oxygenation during prehospital anaesthesia and determining the long-term outcomes.

Methods: We performed a prospective observational feasibility study in two helicopter emergency medical services units. Read More

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The effect of vasoconstriction on intestinal perfusion is determined by preload dependency: A prospective observational study.

Acta Anaesthesiol Scand 2022 Mar 26. Epub 2022 Mar 26.

Department of Anesthesiology and Intensive Care, Hvidovre Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: The effects of vasoconstriction on cardiac stroke volume (SV) and indices of peripheral and intestinal perfusion are insufficiently described.

Methods: In a non-randomized clinical study, 30 patients undergoing elective rectal surgery were exposed to modulation of preload. The primary endpoint was intestinal perfusion (flux), measured by single-point laser Doppler flowmetry. Read More

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Should we revise the SOFA score? Yes.

Acta Anaesthesiol Scand 2022 Mar 25. Epub 2022 Mar 25.

Centre for Intensive Care and Perioperative Medicine, Jagiellonian University Medical College, Kraków, Poland.

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Low volume proximal suprascapular nerve block after arthroscopic shoulder surgery - A randomised, controlled trial.

Acta Anaesthesiol Scand 2022 Mar 25. Epub 2022 Mar 25.

Department of Anaesthesiology and Intensive Care, Nordsjaellands Hospital, Hillerød, Denmark.

Background: A proximal suprascapular nerve block has been suggested as an alternative to an interscalene brachial plexus block after arthroscopic shoulder surgery. The aim of this randomised controlled trial was to compare the analgesic and opioid-sparing effect of a low volume proximal suprascapular nerve block with placebo in patients with moderate-to-severe pain after arthroscopic shoulder surgery.

Methods: Patients with a VAS score equal to or above 50 during the first postoperative hour after planned arthroscopic shoulder surgery were included in the study. Read More

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Chronic critical illness in polytrauma. Results of the Spanish trauma in ICU registry.

Acta Anaesthesiol Scand 2022 Mar 25. Epub 2022 Mar 25.

Transplant Coordination Unit & Service of Intensive Care, University Hospital Marqués de Valdecilla-IDIVAL, School of Medicine, University of Cantabria, Santander, Spain.

Purpose: Chronic critical illness after trauma injury has not been fully evaluated, and there is little evidence in this regard. We aim to describe the prevalence and risk factors of chronic critical illness (CCI) in trauma patients admitted to the intensive care unit.

Material And Methods: Retrospective observational multicenter study (Spanish Registry of Trauma in ICU (RETRAUCI)). Read More

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The Karolinska NeuroCOVID study protocol: Neurocognitive impairment, biomarkers and advanced imaging in critical care survivors.

Acta Anaesthesiol Scand 2022 Mar 25. Epub 2022 Mar 25.

Deptartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.

Background: This is the study plan of the Karolinska NeuroCOVID study, a study of neurocognitive impairment after severe COVID-19, relating post-intensive care unit (ICU) cognitive and neurological deficits to biofluid markers and MRI. The COVID-19 pandemic has posed enormous health challenges to individuals and health-care systems worldwide. An emerging feature of severe COVID-19 is that of temporary and extended neurocognitive impairment, exhibiting a myriad of symptoms and signs. Read More

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Perioperative prevention of persistent pain after total hip and knee arthroplasty-Protocol for two systematic reviews.

Acta Anaesthesiol Scand 2022 Mar 24. Epub 2022 Mar 24.

Department of Orthopaedic Surgery and Traumatology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Background: Between 9% and 20% of patients experience moderate to severe persistent postoperative pain after total hip or knee arthroplasty. Severe immediate postoperative pain limits rehabilitation and is associated with the development of persistent postoperative pain. Therefore, perioperative analgesic and physiotherapeutic interventions are of interest to reduce persistent pain. Read More

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High-dose preoperative glucocorticoid for prevention of emergence and postoperative delirium in liver resection: A double-blinded randomized clinical trial substudy.

Acta Anaesthesiol Scand 2022 Mar 24. Epub 2022 Mar 24.

Department of Anesthesiology, Centre for Cancer and Organ Diseases, Rigshospitalet Copenhagen University Hospital, Copenhagen, Denmark.

Background: Emergence delirium (ED) and postoperative delirium (POD) are associated with increased morbidity and mortality and occur in up to one-third of patients undergoing major non-cardiac surgery, where the underlying pathogenesis is multifactorial, including increased inflammation. We aimed to assess the effect of pre-operative high- versus low-dose glucocorticoid on the occurrence of ED and POD.

Methods: This was a substudy from a randomized, double-blinded clinical trial. Read More

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Continuously monitored vital signs for detection of myocardial injury in high-risk patients - An observational study.

Acta Anaesthesiol Scand 2022 Mar 5. Epub 2022 Mar 5.

Department of Anaesthesia and Intensive Care, Bispebjerg and Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Patients are at risk of myocardial injury after major non-cardiac surgery and during acute illness. Myocardial injury is associated with mortality, but often asymptomatic and currently detected through intermittent cardiac biomarker screening. This delays diagnosis, where vital signs deviations may serve as a proxy for early signs of myocardial injury. Read More

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Improved 60-day survival but impaired general health in Swedish ICU-COVID patients: An ambidirectional population-based study.

Acta Anaesthesiol Scand 2022 05 14;66(5):569-579. Epub 2022 Mar 14.

Department of Infectious Diseases, and Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background: Survival among critically ill COVID-19 patients varies between countries and time periods. Mortality rates up to 60% have been reported in intensive care units (ICUs). Standard-of-care has evolved throughout the pandemic. Read More

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Primary graft dysfunction following lung transplant: Unknowns best ushered by knowns.

Acta Anaesthesiol Scand 2022 05 1;66(5):651-652. Epub 2022 Mar 1.

Department of Cardiac Anesthesiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bengaluru, India.

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A Copernican response: To know what we know.

Acta Anaesthesiol Scand 2022 05 6;66(5):653-654. Epub 2022 Mar 6.

Department of Clinical Sciences, Lund University, Lund, Sweden.

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Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest.

Acta Anaesthesiol Scand 2022 05 28;66(5):615-624. Epub 2022 Mar 28.

Critical Care and Anaesthesiology Research Group, Stavanger University Hospital, Stavanger, Norway.

Background: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM.

Methods: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Read More

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