672,913 results match your criteria Acta Agriculturae Scandinavica Section B-soil And Plant Science[Journal]


Epoxyalcohol synthase activity of the CYP74B enzymes of higher plants.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 May 25:158743. Epub 2020 May 25.

Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, P.O. Box 30, 420111 Kazan, Russia. Electronic address:

The CYP74B subfamily of fatty acid hydroperoxide transforming cytochromes P450 includes the most common plant enzymes. All CYP74Bs studied yet except the CYP74B16 (flax divinyl ether synthase, LuDES) and the CYP74B33 (carrot allene oxide synthase, DcAOS) are 13-hydroperoxide lyases (HPLs, synonym: hemiacetal synthases). The results of present work demonstrate that additional products (except the HPL products) of fatty acid hydroperoxides conversion by the recombinant StHPL (CYP74B3, Solanum tuberosum), MsHPL (CYP74B4v1, Medicago sativa), and CsHPL (CYP74B6, Cucumis sativus) are epoxyalcohols. Read More

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http://dx.doi.org/10.1016/j.bbalip.2020.158743DOI Listing

Decellularized Tissues as Platforms for In Vitro Modeling of Healthy and Diseased Tissues.

Acta Biomater 2020 May 25. Epub 2020 May 25.

J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, 1275 Center Dr. BMS J257, Gainesville, FL USA 32611. Electronic address:

Biomedical engineers are at the forefront of developing novel treatments to improve human health, however, many products fail to translate to clinical implementation. In vivo pre-clinical animal models, although the current best approximation of complex disease conditions, are limited by reproducibility, ethical concerns, and poor accurate prediction of human response. Hence, there is a need to develop physiologically relevant, low cost, scalable, and reproducible in vitro platforms to provide reliable means for testing drugs, biomaterials, and tissue engineered products for successful clinical translation. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.031DOI Listing

Collagen hydrogel confinement of Amyloid-β (Aβ) accelerates aggregation and reduces cytotoxic effects.

Acta Biomater 2020 May 25. Epub 2020 May 25.

Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, Baltimore, Maryland, USA. Electronic address:

Alzheimer's disease (AD) is the most common form of dementia and is associated with the accumulation of amyloid-β (Aβ), a peptide whose aggregation has been associated with neurotoxicity. Drugs targeting Aβ have shown great promise in 2D in vitro models and mouse models, yet preclinical and clinical trials for AD have been highly disappointing. We propose that current in vitro culture systems for discovering and developing AD drugs have significant limitations; specifically, that Aβ aggregation is vastly different in these 2D cultures carried out on flat plastic or glass substrates vs. Read More

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http://dx.doi.org/10.1016/j.actbio.2020.05.030DOI Listing

Effect of uremic state in intestine through a co-culture in vitro intestinal epithelial model.

Int J Pharm 2020 May 25:119450. Epub 2020 May 25.

I3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; Faculdade de Medicina Dentária, Universidade do Porto, Porto, Portugal.

The progressive loss of renal function in chronic kidney disease (CKD) leads to the accumulation of uremic toxins. Recent studies related uremic plasma as well dysbiotic gut microbiome to impaired intestinal barrier function, allowing the translocation of microorganisms or by-products from the intestinal lumen to systemic circulation, contributing to systemic inflammation, cardiovascular risk and progression of CKD. Our main goal was to evaluate the impact of different uremic conditions on an improved in vitro intestinal Caco-2/HT29-MTX/Raji B triple co-culture model. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119450DOI Listing

Cardiac biomarker measurement by point of care testing - Development, rationale, current state and future developments.

Authors:
Paul Collinson

Clin Chim Acta 2020 May 25. Epub 2020 May 25.

Departments of Clinical Blood Sciences and Cardiology, St George's University Hospitals NHS Foundation Trust and St George's University of London, Cranmer Terrace, London SW17 0QT, UK. Electronic address:

Cardiac biomarker measurements are integral to the diagnosis and management of patients presenting with breathlessness and chest pain. Measurement of B type natriuretic peptide either directly or of the N-terminal portion of the prohormone although possible by point of care testing (POCT) has largely become a laboratory test. Measurement of the cardiac troponins cardiac troponin T (cTnT) and cardiac troponin I (cTnI) can easily and accurately be performed by POCT. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.018DOI Listing

The insecticide fipronil affects the physical properties of model membranes: A combined experimental and molecular dynamics simulations study in Langmuir monolayers.

Biochim Biophys Acta Biomembr 2020 May 25:183378. Epub 2020 May 25.

Universidad Nacional de Córdoba, Facultad de Ciencias Exactas, Físicas y Naturales, Departamento de Química, Cátedra de Química Biológica, Córdoba, Argentina; Instituto de Investigaciones Biológicas y Tecnológicas, Consejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address:

Fipronil is a widely used commercial insecticide whose action mechanism consists in blocking the influx of chloride ions through the γ-aminobutyric acid type A receptor (GABA-R), an integral membrane protein. The present study investigates the interaction of fipronil with phospholipid Langmuir monolayers, in order to characterize the effects that its partition could exert on the physical properties of these model membranes. A combined experimental and molecular dynamics (MD) simulations approach was performed. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183378DOI Listing

Phase separation behavior of binary mixture of photopolymerizable diacetylene and unsaturated phospholipids in liposomes.

Biochim Biophys Acta Biomembr 2020 May 25:183377. Epub 2020 May 25.

Center for Membrane and Film Technology, Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan. Electronic address:

Photopolymerizable lipids, such as diacetylene lipids have attracted much attention for their ability to stabilize lipid bilayer structure. In this study, we investigated the phase separation behavior of a lipid bilayer containing 1,2‑bis(10,12‑tricosadiynoyl)‑sn‑glycero‑3‑phosphocholine (DiynePC). The phase separation behavior of liposomes composed of DiynePC and the non-polymerizable lipid, 1,2‑dioleoyl‑sn‑glycero‑3‑phosphocholine (DOPC) was evaluated using a fluorescence resonance energy transfer (FRET) assay during both the cooling and heating processes. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183377DOI Listing

Quality of Life in Bell's Palsy: Correlation with Sunnybrook and House-Brackmann Over Time.

Laryngoscope 2020 May 28. Epub 2020 May 28.

Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Ear, Nose, and Throat Diseases, Karolinska University Hospital, Stockholm, Sweden.

Objectives: To compare patient-graded facial and social/well-being function with physician-graded facial function in Bell's palsy over time.

Study Design: A prospective follow-up study at two tertiary otorhinolaryngological centers.

Methods: A total of 96 patients, 36 women and 60 men, aged 18-77 years, were included. Read More

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http://dx.doi.org/10.1002/lary.28751DOI Listing

Dicalcium silicate microparticles modulate the differential expression of circRNAs and mRNAs in BMSCs and promote osteogenesis via circ_1983-miR-6931-Gas7 interaction.

Biomater Sci 2020 May 28. Epub 2020 May 28.

Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510140, China.

Dicalcium silicate microparticle (C2S)-based biomaterials have a potential for bone and dental tissue regenerative applications. The C2S-mediated transcriptome level mechanism in mesenchymal stem cells (MSCs) during bone-defect healing has not been investigated yet. In this study, we elucidated the differential expression pattern of messenger RNAs (mRNAs) and circular RNAs (circRNAs) in C2S-treated MSCs and their involvement in the osteogenesis process. Read More

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http://dx.doi.org/10.1039/d0bm00459fDOI Listing

Comorbidity and early death in Danish stage I lung cancer patients - an individualised approach.

Acta Oncol 2020 May 28:1-8. Epub 2020 May 28.

Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark.

Comorbidity is an important prognostic marker and a treatment indicator for lung cancer patients. Register-based studies often describe the burden of comorbidity by the Charlson comorbidity index (CCI) based on hospital discharge data. We assessed the association between somatic and psychiatric comorbidity and death within one year in early lung cancer and, furthermore, the burden of comorbidity according to treatment type. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1764096DOI Listing

Impact of smoking on gestational diabetes mellitus and offspring birthweight in primiparous women.

Acta Obstet Gynecol Scand 2020 May 28. Epub 2020 May 28.

Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Introduction: Smoking has been shown to affect glucose homeostasis and increase the risk for type 2 diabetes mellitus. Further, gestational diabetes mellitus (GDM) and smoking are known to influence offspring birthweight. The effect of smoking on glucose homeostasis in pregnancy is less studied and the findings are inconsistent. Read More

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http://dx.doi.org/10.1111/aogs.13924DOI Listing

Resources needed to teach midwife sonographers to measure cervical length with transvaginal ultrasound in the second trimester.

Acta Obstet Gynecol Scand 2020 May 28. Epub 2020 May 28.

Department of Obstetrics and Gynecology, Skåne University Hospital, Malmö, Sweden.

General screening of singleton pregnancies for preterm delivery by adding cervical length measurement with transvaginal ultrasound to second trimester routine fetal ultrasound examination has been advocated . Reference ranges of cervical length are available from 11 to 40 weeks of gestation. In the Nordic countries, second trimester routine ultrasound examinations are performed by specially trained midwife sonographers, and if screening for preterm delivery were to be introduced, cervical length measurements would be done by them. Read More

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http://dx.doi.org/10.1111/aogs.13926DOI Listing

Sepsis is underreported in Swedish intensive care units: a retrospective observational multicentre study.

Acta Anaesthesiol Scand 2020 May 28. Epub 2020 May 28.

Department of Clinical Medicine, Anaesthesiology and Intensive Care, Lund University, SE-22185, Lund, Sweden.

Background: Sepsis is a common indication for admission to the intensive care unit (ICU). Since definitions vary across studies, comparisons of prevalence and outcomes have been challenging. We aimed to compare sepsis according to ICU discharge codes with sepsis according to Sepsis-3 criteria and to investigate the epidemiology of sepsis in the ICU. Read More

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http://dx.doi.org/10.1111/aas.13647DOI Listing

Onset time and duration of action of rocuronium 0.6 mg/kg in patients above 80 years of age: A comparison with young adults.

Acta Anaesthesiol Scand 2020 May 27. Epub 2020 May 27.

Department of Anaesthesia, Centre of Head and Orthopaedics, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Background: The number of elderly is increasing, and a large proportion of these people will require surgery and anaesthesia. However, little data exist regarding rocuronium in patients above 80 years of age. The aim of this study was to determine the onset time and duration of action for rocuronium 0. Read More

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http://dx.doi.org/10.1111/aas.13645DOI Listing

Nanobody-based electrochemical competitive immunosensor for the detection of AFB through AFB-HCR as signal amplifier.

Mikrochim Acta 2020 May 28;187(6):352. Epub 2020 May 28.

Key Lab for Agro-product Processing and Quality Control of Nanchang City, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, 330045, China.

A novel nanobody (Nb)-based voltammetric immunosensor coupled with horseradish peroxidase concatemer-modified hybridization chain reaction (HRP-HCR) signal amplifying system is described to realize the rapid and ultrasensitive detection of AFB. To design such an immunoassay, anti-AFB Nbs with smaller molecular size were coated densely onto the surface of Au nanoparticle-tungsten disulfide-multi-walled carbon nanotubes (AuNPs/WS/MWCNTs) functional nanocomposites as an effective molecular recognition element, whereas AFB-streptavidin (AFB-SA) conjugates were ingeniously bound with biotinylated HCR dsDNA nanostructures as the competitor, amplifier, and signal report element. In the presence of AFB targets, a competitive immunoreaction was performed between the analyte and AFB-SA-labeled HCR (AFB-HCR) platform. Read More

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http://dx.doi.org/10.1007/s00604-020-04343-2DOI Listing

Functionalized carbon quantum dots as fluorescent nanoprobe for determination of tetracyclines and cell imaging.

Mikrochim Acta 2020 May 28;187(6):351. Epub 2020 May 28.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, 110016, Liaoning Province, People's Republic of China.

Nitrogen and sulfur co-doped carbon dots (N, S-CQDs) with high fluorescent, water-soluble, low-toxicity properties were synthesized by microwave-assisted hydrothermal approach. The prepared N, S-CDs exhibited high selectivity in detection of tetracyclines (TCs) and displayed a fast-responsive fluorescence quenching signal in the mixture, which are mainly attributed to the inner filter effect (IFE). The synthesized N, S-CQDs are successfully used as a fluorescent nanoprobe for the determination of CTC in milk samples (with excitation/emission maxima at 373/424 nm). Read More

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http://dx.doi.org/10.1007/s00604-020-04328-1DOI Listing

Common peroneal nerve entrapment: the need for a complete assessment before surgery.

Acta Neurochir (Wien) 2020 May 28. Epub 2020 May 28.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Via G. Celoria 11, 20133, Milan, Italy.

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http://dx.doi.org/10.1007/s00701-020-04410-wDOI Listing

High prevalence of pro-thrombotic conditions in adult patients with moyamoya disease and moyamoya syndrome: a single center study.

Acta Neurochir (Wien) 2020 May 28. Epub 2020 May 28.

Mayo Clinic Department of Neurology, 200 1st St. SW, Rochester, MN, 55905, USA.

Background: Moyamoya Disease (MMD) and moyamoya Syndrome (MMS) have been reported to be associated with pro-thrombotic states in some patients. To date, however, such reports have been limited to case reports or small case series. We sought to determine the prevalence of pro-thrombotic states among a large cohort of both MMD and MMS patients. Read More

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http://dx.doi.org/10.1007/s00701-020-04420-8DOI Listing

A double carbon dot system composed of N, Cl-doped carbon dots and N, Cu-doped carbon dots as peroxidase mimics and as fluorescent probes for the determination of hydroquinone by fluorescence.

Mikrochim Acta 2020 May 28;187(6):350. Epub 2020 May 28.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan Province, China.

A fluorescence method is described for the determination of hydroquinone based on the double carbon dot system as peroxide mimic enzymes and fluorescent probes. Deep eutectic solvent (DES)-based fluorescent carbon dots (N/Cl-CDs) and copper-doped carbon dots (N/Cu-CDs) were prepared by the hydrothermal method. Both carbon dots were characterized with transmission electron microscopy (TEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), ultraviolet-visible (UV-Vis) spectroscopy, X-ray photoelectron spectrometry (XPS), Fourier transform infrared (FT-IR) spectroscopy, and fluorescence spectroscopy. Read More

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http://dx.doi.org/10.1007/s00604-020-04322-7DOI Listing

Hematological and Biochemical Changes in Naturally Occurring Equine Piroplasmosis in Donkeys (Equus asinus) of Northwest of Iran.

Acta Parasitol 2020 May 27. Epub 2020 May 27.

Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

Purpose: Equine piroplasmosis is a tick-borne protozoal disease affecting horses, mules, donkeys and zebras and can lead to severe economic losses in the equine industry. There is limited information on clinical pathologic changes of equine piroplasmosis in donkeys. This study aims to investigate the impacts of babesiosis on various hematological and biochemical properties in naturally infected donkeys with Theileria equi and Babesia caballi. Read More

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http://dx.doi.org/10.2478/s11686-020-00223-0DOI Listing

Photocatalytically renewable peptide-based electrochemical impedance method for sensing lipopolysaccharide.

Mikrochim Acta 2020 May 27;187(6):349. Epub 2020 May 27.

State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology, China University of Petroleum (East China), Qingdao, 266580, Shandong, People's Republic of China.

A peptide (Li5-025)-modified gold nanoparticle (AuNP)/(titania (TiO) + 5,10,15,20-tetrakis(4-aminophenyl)-21H,23H-porphine (TAPP))/glassy carbon electrode (GCE) was developed for lipopolysaccharide (LPS) determination. This electrode not only performs well in the electrochemical impedance determination of LPS in serum but can also be easily regenerated under light irradiation. Using Fe(CN) as a redox probe, LPS recognition can be indicated by the significantly increased electron-transfer resistance (R) as a result of the coaction of the increased steric hindrance from the peptide-LPS complex and the electrostatic repulsion between LPS and Fe(CN). Read More

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http://dx.doi.org/10.1007/s00604-020-04321-8DOI Listing

Oriented boronate affinity-imprinted inverse opal hydrogel for glycoprotein assay via colorimetry.

Mikrochim Acta 2020 May 27;187(6):348. Epub 2020 May 27.

Department of Biomedical Engineering, The First Affiliated Hospital, Shenzhen University, Shenzhen, 518035, China.

A biomimetic antibody is described for colorimetric determination of glycoprotein, and horseradish peroxidase (HRP) is used as model analyte. Use is made of oriented surface imprinted inverse opal hydrogel particles functionalized with phenylboronic acid. The inverse opal hydrogel particles were negatively replicated from silica colloidal crystal beads (SCCBs), so that they were endowed with larger specific surface area than the bulk structure. Read More

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http://dx.doi.org/10.1007/s00604-020-04320-9DOI Listing

Planochromism of cyanoxime anions: computational and mechanistic studies in solid state and solutions.

Inorganica Chim Acta 2020 Jul 17;507. Epub 2020 Mar 17.

Temple Hall 431, Department of Chemistry, Missouri State University, Springfield, MO 65897, USA.

The benzoylcyanoxime, NC-C(=N-OH)-C(O)-CH (later H(BCO)), represents a new ampolydentate ligand that received attention in the light of useful biological properties of its coordination compounds. Colorless H(BCO), upon deprotonation, gains color that depends on the counter-cation and the system in general. Five derivatives of H(BCO), with colorless organic and inorganic mono-cations - Cs, Tl, Ag, N(CH) and As(CH) - were synthesized and characterized by the X-ray analysis, vibrational and electronic spectroscopy. Read More

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http://dx.doi.org/10.1016/j.ica.2020.119570DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252209PMC

Emerging functions and clinical prospects of connexins and pannexins in melanoma.

Biochim Biophys Acta Rev Cancer 2020 May 24:188380. Epub 2020 May 24.

CellCOM Group, Instituto de Investigación Biomédica de A Coruña (INIBIC), Servizo Galego de Saúde (SERGAS), Universidade da Coruña, Xubias de Arriba, 84, 15006 A Coruña, Spain. Electronic address:

Cellular communication through gap junctions and hemichannels formed by connexins and through channels made by pannexins allows for metabolic cooperation and control of cellular activity and signalling. These channel proteins have been described to be tumour suppressors that regulate features such as cell death, proliferation and differentiation. However, they display cancer type-dependent and stage-dependent functions and may facilitate tumour progression through junctional and non-junctional pathways. Read More

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http://dx.doi.org/10.1016/j.bbcan.2020.188380DOI Listing

Risk factors associated with seropositivity for Toxoplasma gondii in population-based studies among immunocompromised patients (pregnant women, HIV patients and children) in West African countries, Cameroon and Gabon: a meta-analysis.

Acta Trop 2020 May 24:105544. Epub 2020 May 24.

Department of Veterinary Parasitology and Entomology, University of Ibadan, Nigeria. Electronic address:

Toxoplasmosis in immunocompromised individuals can be life threatening. The information needed for proper control and management strategies in endemic West African countries is lacking, hence a systematic review and meta-analysis were performed. This study aimed to determine the seroprevalence of anti-Toxoplasma gondii among pregnant women, HIV/AIDs and children in West Africa, Cameroon and Gabon. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105544DOI Listing

LEISHMANICIDAL ACTIVITY in vivo OF A MILTEFOSINE DERIVATIVE IN Mesocricetus auratus.

Acta Trop 2020 May 24:105539. Epub 2020 May 24.

Department of Pathology and Parasitology, Institute of Biomedical Science, Universidade Federal de Alfenas, Minas Gerais state, Brazil. Electronic address:

Visceral leishmaniasis (VL) is a chronic and systemic disease; if untreated, it can cause death in a large number of cases. The therapy is based on the use of antimonials, which have been used for over 50 years. However, cases of resistance have been reported in some countries. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105539DOI Listing

Emerging role of Insig-1 in lipid metabolism and lipid disorders.

Clin Chim Acta 2020 May 24. Epub 2020 May 24.

Clinical Anatomy & Reproductive Medicine Application Institute, Hengyang Medical College, University of South China, Hengyang 421001, Hunan, China; Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin 541000, Guangxi, China. Electronic address:

Growing evidence has demonstrated that Insig-1 is intricately involved in lipid metabolism regulation and the progression of lipid disorders. Our review summarizes updated information on the role and underlying mechanisms of Insig-1 in lipid metabolism dyshomeostasis and lipid disorders. As a member of the insulin-induced gene family, insulin-induced gene 1 (Insig-1) is a six-span transmembrane protein embedded in the endoplasmic reticulum (ER) membrane. Read More

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http://dx.doi.org/10.1016/j.cca.2020.05.042DOI Listing

Infection with brainworm (Elaphostrongylus rangiferi) in reindeer (Rangifer tarandus ssp.) in Fennoscandia.

Acta Vet Scand 2020 May 27;62(1):24. Epub 2020 May 27.

Finnish Food Authority (FINPAR), Oulu, Finland.

Sami reindeer herders have considerable traditional knowledge about a neurological reindeer disease resembling elaphostrongylosis, but the causative agent was not identified prior to the description of the brainworm Elaphostrongylus rangiferi in Russia in 1958. Elaphostrongylosis was quickly recognised as a serious cause of reindeer morbidity and mortality. The ecology, epidemiology and pathophysiology of the disease were studied in Sweden and Norway during the 1960s and in particular the 1970s to 1990s. Read More

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http://dx.doi.org/10.1186/s13028-020-00524-4DOI Listing

Ultra-low-dose CT-guided lung biopsy in clinic: radiation dose, accuracy, image quality, and complication rate.

Acta Radiol 2020 May 27:284185120917622. Epub 2020 May 27.

Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.

Background: Computed tomography (CT)-guided percutaneous lung biopsy is usually performed by helical scanning. However, there are no studies on radiation dose, diagnostic accuracy, image quality, and complications based on axial scan mode.

Purpose: To determine radiation dose, accuracy, image quality, and complication rate following an ultra-low-dose (ULD) protocol for CT-guided lung biopsy in clinic. Read More

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http://dx.doi.org/10.1177/0284185120917622DOI Listing

Mouthguard use and TMJ injury prevention with different occlusions: A three-dimensional finite element analysis.

Dent Traumatol 2020 May 27. Epub 2020 May 27.

Department of Oral Cell Biology and Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU UniversityAmsterdam, Amsterdam, The Netherlands.

Background/aims: There is a lack of data regarding the temporomandibular joint's mechanical response during an impact to the orofacial region. The aim of this study was to analyze the biomechanical effects of wearing a mouthguard (MG) on the impact response of the mandibular condyle and articular disc according to the type of occlusion. The hypothesis was that the MG would minimize the effect in those structures, regardless of the occlusion type. Read More

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http://dx.doi.org/10.1111/edt.12577DOI Listing

Influence of maternal region of birth on neonatal outcomes of babies born small.

Acta Paediatr 2020 May 27. Epub 2020 May 27.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, Australia.

Aim: To compare neonatal outcomes of Small for Gestational Age (SGA) infants born to South Asian (SA)-born women, and Australia New Zealand (ANZ)-born women.

Methods: Retrospective cohort study at a hospital network in Australia. Maternal and neonatal data was collected for infants born SGA between 2013-2017 to SA or ANZ-born women. Read More

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http://dx.doi.org/10.1111/apa.15375DOI Listing

Delayed Diagnosis of Pediatric Appendicitis during the COVID-19 Pandemic.

Acta Paediatr 2020 May 27. Epub 2020 May 27.

Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Aim: To present seven pediatric patients with appendicitis, all with late diagnosis resulting from different aspects of the fear from the current global COVID-19 pandemic.

Methods: Cases were collected from three pediatric surgical wards. Comparison between complicated appendicitis rates in the COVID-19 era and similar period in previous year was performed. Read More

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http://dx.doi.org/10.1111/apa.15376DOI Listing

Acquired hemophilia A revealed by spontaneous bleeding in an 80-year-old man: a marginal diagnosis?

Acta Clin Belg 2020 May 27:1-3. Epub 2020 May 27.

Department of Hematology, Hôpital Erasme, Université Libre De Bruxelles , Brussels, Belgium.

This case report illustrates the difficulty associated with diagnosing acquired hemophilia A by reviewing the case of an 80-year-old man admitted to the hospital for anemia. A prolonged activated partial thromboplastin time (aPTT) was not noticed until the patient developed a severe hemorrhagic syndrome. Read More

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http://dx.doi.org/10.1080/17843286.2020.1768735DOI Listing

[COVID-19 and The Invisible Damage: The Role of The Family Physician].

Authors:
Maria Gouveia

Acta Med Port 2020 May 27. Epub 2020 May 27.

Unidade de Saúde Familiar de São Julião. Agrupamento de Centros de Saúde de Lisboa Ocidental e Oeiras. Lisboa. Portugal.

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http://dx.doi.org/10.20344/amp.14157DOI Listing

Desloratadine and loratadine stand out among common H-antihistamines for association with improved breast cancer survival.

Acta Oncol 2020 May 27:1-7. Epub 2020 May 27.

Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.

As tumors maintain an inflammatory microenvironment, anti-inflammatory medication can be useful in cancer therapy. We have previously shown an association with improved survival in melanoma for use of the H-antihistamines desloratadine and loratadine, and here we examine use of H-antihistamines and breast cancer mortality. We investigated use of the six major H-antihistamines (cetirizine, clemastine, desloratadine, ebastine, fexofenadine and loratadine) and breast cancer-specific and overall mortality in a nation-wide register-based study of all 61,627 Swedish women diagnosed with breast cancer 2006-2013. Read More

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http://dx.doi.org/10.1080/0284186X.2020.1769185DOI Listing

Efficiency of chemical versus mechanical disruption methods of DNA extraction for the identification of oral Gram-positive and Gram-negative bacteria.

J Int Med Res 2020 May;48(5):300060520925594

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objective: Clinical diagnostics often requires the detection of multiple bacterial species in limited clinical samples with a single DNA extraction method. This study aimed to compare the bacterial DNA extraction efficiency of two lysis methods automated with the MagNA-Pure LC instrument. The samples included five oral bacterial species (three Gram-positive and two Gram-negative) with or without human saliva background. Read More

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http://dx.doi.org/10.1177/0300060520925594DOI Listing

TBK1, a central kinase in innate immune sensing of nucleic acids and beyond.

Acta Biochim Biophys Sin (Shanghai) 2020 May 27. Epub 2020 May 27.

MOE Laboratory of Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou 310058, China.

Sensing of intracellular and extracellular environments is one of the fundamental processes of cell. Surveillance of aberrant nucleic acids, derived either from invading pathogens or damaged organelle, is conducted by pattern recognition receptors (PRRs) including RIG-I-like receptors, cyclic GMP-AMP synthase, absent in melanoma 2, and a few members of toll-like receptors. TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes. Read More

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http://dx.doi.org/10.1093/abbs/gmaa051DOI Listing

High-intensity vessel sign on fluid-attenuated inversion recovery imaging: a novel imaging marker of high-risk carotid stenosis-a MRI and SPECT study.

Acta Neurochir (Wien) 2020 May 26. Epub 2020 May 26.

Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Background: Measurement of luminal stenosis and determination of plaque instability using MR plaque imaging are effective strategies for evaluating high-risk carotid stenosis. Nevertheless, new methods are required to identify patients with carotid stenosis at risk of future stroke. We aimed to clarify the mechanisms and clinical implications of the hyperintense vessel sign (HVS) as a marker of high-risk carotid stenosis. Read More

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http://dx.doi.org/10.1007/s00701-020-04408-4DOI Listing

Superior accuracy and precision of SEEG electrode insertion with frame-based vs. frameless stereotaxy methods.

Acta Neurochir (Wien) 2020 May 26. Epub 2020 May 26.

Department of Neurosurgery, University of California Davis School of Medicine, 4860 Y St. Suite 3740, Sacramento, 95817, USA.

Background: Stereotactic electroencephalography (SEEG) has largely become the preferred method for intracranial seizure localization in epileptic patients due to its low morbidity and minimally invasive approach. While robotic placement is gaining popularity, many centers continue to use manual frame-based and frameless methods for electrode insertion. However, it is unclear how these methods compare in regard to accuracy, precision, and safety. Read More

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http://dx.doi.org/10.1007/s00701-020-04427-1DOI Listing

Promoted off-on recognition of HO based on the fluorescence of silicon quantum dots assembled two-dimensional PEG-MnO nanosheets hybrid nanoprobe.

Mikrochim Acta 2020 May 26;187(6):347. Epub 2020 May 26.

Guangdong Provincial Engineering Technology Research Center for Optical Agriculture, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, People's Republic of China.

An "off-on" assay system for HO determination was developed based on assembling ultra-bright fluorescent silicon quantum dots (SiQDs) and PEG-MnO nanosheets. Among them, SiQDs acted as fluorometric reporter, which can effectively eliminate the interference of plant pigments under excitation of 365 nm. PEG-MnO nanosheets played dual function of nanoquencher and HO recognizer. Read More

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http://dx.doi.org/10.1007/s00604-020-04276-wDOI Listing

In situ encapsulation of horseradish peroxidase in zeolitic imidazolate framework-8 enables catalyzing luminol reaction under near-neutral conditions for sensitive chemiluminescence determination of cholesterol.

Mikrochim Acta 2020 May 26;187(6):346. Epub 2020 May 26.

Department of Chemistry, School of Science, Xi'an Jiaotong University, Xi'an, 710049, China.

HRP@ZIF-8 nanocomposite was prepared by in situ encapsulation of horseradish peroxidase (HRP) in the frame of zeolitic imidazolate framework-8 (ZIF-8) with a simple one-pot method. The HRP@ZIF-8 nanocomposite displays outstanding thermal stability and efficiently catalyzes the chemiluminescence (CL) reaction of luminol with hydrogen peroxide (HO) under near-neutral pH condition (pH 7-8). This CL system has a good response to HO with a linear range of 0. Read More

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http://dx.doi.org/10.1007/s00604-020-04313-8DOI Listing

Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14.

Acta Pharmacol Sin 2020 May 26. Epub 2020 May 26.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.

Previous studies have shown that baicalin, an active ingredient of the Chinese traditional medicine Huangqin, attenuates LPS-induced inflammation by inhibiting the activation of TLR4/NF-κBp65 pathway, but how it affects this pathway is unknown. It has been shown that CD14 binds directly to LPS and plays an important role in sensitizing the cells to minute quantities of LPS via chaperoning LPS molecules to the TLR4/MD-2 signaling complex. In the present study we investigated the role of CD14 in the anti-inflammatory effects of baicalin in vitro and in vivo. Read More

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http://dx.doi.org/10.1038/s41401-020-0411-9DOI Listing

Blockage of sphingosine-1-phosphate receptor 2 attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice.

Acta Pharmacol Sin 2020 May 26. Epub 2020 May 26.

College of Pharmacy, Pusan National University, Busan, 46241, Republic of Korea.

Sphingosine-1-phosphate (S1P) and its receptors have been implicated in functions of Langerhans cells and atopic dermatitis. In this study, we investigated the roles of S1P receptor type 2 (S1P) in a mouse model of atopic dermatitis, which was induced by topical application of 2,4-dinitrochlorobenzene (DNCB) on ventral skin on D0, followed by repeated DNCB challenge on both ears from D7 to D49. Wild-type mice with atopic dermatitis displayed severe inflammation and mast cell accumulation in ear tissues and elevated IgE levels in serum. Read More

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http://dx.doi.org/10.1038/s41401-020-0412-8DOI Listing

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure.

Acta Pharmacol Sin 2020 May 26. Epub 2020 May 26.

State Key Laboratory of Natural Medicines, Key Laboratory of Drug Metabolism, China Pharmaceutical University, Nanjing, 210009, China.

Programmed cell death (PCD), including apoptosis, apoptotic necrosis, and pyroptosis, is involved in various organ dysfunction syndromes. Recent studies have revealed that a substrate of caspase-3, gasdermin E (GSDME), functions as an effector for pyroptosis; however, few inhibitors have been reported to prevent pyroptosis mediated by GSDME. Here, we developed a class of GSDME-derived inhibitors containing the core structure of DMPD or DMLD. Read More

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http://dx.doi.org/10.1038/s41401-020-0434-2DOI Listing

Application of targeted therapy strategies with nanomedicine delivery for atherosclerosis.

Acta Pharmacol Sin 2020 May 26. Epub 2020 May 26.

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.

Atherosclerosis (AS) is the main pathological cause of coronary heart disease (CHD). Current clinical interventions including statin drugs can effectively reduce acute myocardial infarction and stroke to some extent, but residual risk remains high. The current clinical treatment regimens are relatively effective for early atherosclerotic plaques and can even reverse their progression. Read More

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http://dx.doi.org/10.1038/s41401-020-0436-0DOI Listing

Author Correction: Ophiopogonin D maintains Ca homeostasis in rat cardiomyocytes in vitro by upregulating CYP2J3/ EETs and suppressing ER stress.

Acta Pharmacol Sin 2020 May 26. Epub 2020 May 26.

Department of Pharmacology and Toxicology, Beijing Institute of Radiation Medicine, Beijing, 100850, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper. Read More

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http://dx.doi.org/10.1038/s41401-020-0428-0DOI Listing

Diabetic Striatopathy.

Acta Med Port 2020 May 26. Epub 2020 May 26.

Department of Medicine. Faculty of Medicine. Chulalongkorn University. Bangkok. Excellent Center in Diabetes, Hormone and Metabolism. King Chulalongkorn Memorial Hospital. Thai Red Cross Society. Bangkok. Thailand.

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http://dx.doi.org/10.20344/amp.13111DOI Listing

The use of tear ferning test in cats for evaluation of ocular surface.

Acta Vet Scand 2020 May 26;62(1):23. Epub 2020 May 26.

Department of Agrarian and Environmental Sciences, Santa Cruz State University, Rodovia Jorge Amado, Ilheus, Bahia, 45662-900, Brazil.

Background: The tear film is a trilaminar fluid composed mainly of lipids, electrolytes, proteins and water. It is responsible for lubrication, nutrition and protection against microbial and toxic agents. Disruption of any these components may weaken the ocular surface, making it more susceptible to disease. Read More

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http://dx.doi.org/10.1186/s13028-020-00523-5DOI Listing
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