705,222 results match your criteria Acta Adriatica[Journal]

Multifaceted regulation of enhancers in cancer.

Biochim Biophys Acta Gene Regul Mech 2022 Jun 21:194839. Epub 2022 Jun 21.

Frontier Science Center for Immunology and Metabolism, Hubei Key Laboratory of Cell Homeostasis, Hubei Key Laboratory of Developmentally Originated Disease, College of Life Sciences, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei 430072, China. Electronic address:

Enhancer is one kind of cis-elements regulating gene transcription, whose activity is tightly controlled by epigenetic enzymes and histone modifications. Active enhancers are classified into typical enhancers, super-enhancers and over-active enhancers, according to the enrichment and location of histone modifications. Epigenetic factors control the level of histone modifications on enhancers to determine their activity, such as histone methyltransferases and acetylases. Read More

View Article and Full-Text PDF

Structural mass spectrometry of membrane proteins.

Biochim Biophys Acta Proteins Proteom 2022 Jun 21:140813. Epub 2022 Jun 21.

Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, UPS, Toulouse, France. Electronic address:

The analysis of proteins and protein complexes by mass spectrometry (MS) has come a long way since the invention of electrospray ionization (ESI) in the mid 80s. Originally used to characterize small soluble polypeptide chains, MS has progressively evolved over the past 3 decades towards the analysis of samples of ever increasing heterogeneity and complexity, while the instruments have become more and more sensitive and resolutive. The proofs of concepts and first examples of most structural MS methods appeared in the early 90s. Read More

View Article and Full-Text PDF

Can Blebbistatin block the hypertrophy status in the zebrafish exvivo cardiac model?

Biochim Biophys Acta Mol Basis Dis 2022 Jun 21:166471. Epub 2022 Jun 21.

Department of Ecological and Biological Sciences, Tuscia University, Viterbo, Italy. Electronic address:

Ex-vivo simple models are powered tools to study cardiac hypertrophy. It is possible to control the activation of critical genes and thus test the effects of drug therapies before the in vivo tests. A zebrafish cardiac hypertrophy developed by 500 μM phenylephrine (PE) treatment in ex vivo culture has been demonstrated to activate the essential expression of the embryonal genes. Read More

View Article and Full-Text PDF

Artificial intelligence channelizing protein-peptide interactions pipeline for host-parasite paradigm in IL-10 and IL-12 reciprocity by SHP-1.

Biochim Biophys Acta Mol Basis Dis 2022 Jun 21:166466. Epub 2022 Jun 21.

National Centre for Cell Science, NCCS Complex, Ganeshkhind, SP Pune University Campus, Pune 411007, INDIA. Electronic address:

Identification of molecular targets in any cellular phenomena is a challenge and a path that one endeavors upon independently. We have identified a phosphatase SHP-1 as a point of intervention of IL-10 and IL-12 reciprocity in leishmaniasis. The therapeutic model that we have developed uniquely targets this protein but the pipeline in general can be used by the researchers for their unique targets. Read More

View Article and Full-Text PDF

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice.

Biochim Biophys Acta Mol Basis Dis 2022 Jun 21:166470. Epub 2022 Jun 21.

CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500007, India. Electronic address:

View Article and Full-Text PDF

Binding of DEP domain to phospholipid membranes: More than just electrostatics.

Biochim Biophys Acta Biomembr 2022 Jun 21:183983. Epub 2022 Jun 21.

CEITEC - Central European Institute of Technology, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic; Department of Condensed Matter Physics, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic. Electronic address:

Over the past decades an extensive effort has been made to provide a more comprehensive understanding of Wnt signaling, yet many regulatory and structural aspects remain elusive. Among these, the ability of Dishevelled (DVL) protein to relocalize at the plasma membrane is a crucial step in the activation of all Wnt pathways. The membrane binding of DVL was suggested to be mediated by the preferential interaction of its C-terminal DEP domain with phosphatidic acid (PA). Read More

View Article and Full-Text PDF

Optimization of the cut-offs in acetylcholine receptor antibodies and diagnostic performance in myasthenia gravis patients.

Clin Chim Acta 2022 Jun 21. Epub 2022 Jun 21.

Department of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:

Objective: This study aims to establish an optimization procedure to define the cut-offs of quantitative assays for acetylcholine receptor antibody (AChRAb), evaluate their diagnostic performance in myasthenia gravis (MG), and explore the association with clinical features.

Methods: Samples from a representative cohort of 77 MG patients, 80 healthy controls (HC) and 80 other autoimmune diseases (OAD) patients were tested using competitive inhibition ELISA and RIA. Raw values (OD and cpm) and processed values (inhibition rate, binding rate and concentration) were used to define the cut-offs with statistical methods, a rough method, and receiver operating characteristic (ROC) curve. Read More

View Article and Full-Text PDF

Smartphone-integrated fluorescent quenching immunochromatographic test strips designed for the determination of sesame allergens in food samples.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 17;280:121522. Epub 2022 Jun 17.

State Key Laboratory for Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, China. Electronic address:

A highly sensitive smartphone-integrated fluorescence quenching immunochromatographic assay (FQICA) for the detection of sesame allergen was proposed. Sesame antibodies were adsorbed on the surface of the gold nanoparticles to form fluorescent acceptors (AuNPs-Ab). Ovalbumin (OVA) protein was labeled with quantum dots (QDs) to form signal probes (QDs-OVA), which were coated on the C-line of the assay strips. Read More

View Article and Full-Text PDF

A "Turn-On" fluorescent probe for detection and removal of Zn in aqueous and its application in living cells.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 15;280:121501. Epub 2022 Jun 15.

State Key Laboratory of Environment-friendly Energy Materials, National Engineering Technology Center for Insulation Materials, School of Material and Chemistry, Southwest University of Science and Technology, Mianyang, 621010, P. R. China. Electronic address:

Using 3-hydroxy-2-naphthoic acid hydrazine and 4-(diethylamino) salicylaldehyde. as raw materials, compound L with an acylhydrazones structure was synthesized. The structure of compound L was characterized by nuclear magnetic resonance spectroscopy, X-ray single crystal diffraction, Fourier transform infrared spectroscopy, and mass spectrometry. Read More

View Article and Full-Text PDF

A design of red emission CDs-based aptasensor for sensitive detection of insulin via fluorescence resonance energy transfer.

Spectrochim Acta A Mol Biomol Spectrosc 2022 Jun 15;280:121497. Epub 2022 Jun 15.

Shanxi Normal University, Taiyuan 030031, PR China.

We successfully designed an aptasensor based on the red emission carbon dots (R-CDs) and effectively detected insulin (INS) via fluorescence resonance energy transfer (FRET). In the process, the aptamer (apt) labeled with R-CDs ([email protected]) was used as fluorescence donor and graphene oxide (GO) was used as fluorescence receptor. The successful detection due to the aptamer sequence has a certain affinity for Go and INS, while the affinity for INS is stronger than that of GO. Read More

View Article and Full-Text PDF

The association between smartphone and tablet usage and children development.

Acta Psychol (Amst) 2022 Jun 21;228:103646. Epub 2022 Jun 21.

Movement Science and Exercise Research Center, Walailak University, Thasala District, Nakhon Si Thammarat Province 80160, Thailand; Physical Therapy Department, School of Allied Health Sciences, Walailak University, Thasala District, Nakhon Si Thammarat Province 80160, Thailand. Electronic address:

Smartphone and tablet usage duration may relate to problems with early development in children. It is imperative to determine the appropriate duration of its usage by children. The purpose of the study was 1) to investigate the correlation between child development and smartphone and tablet usage duration, 2) to study the correlation of smartphone and tablet usage duration between children and their caregivers, and 3) to correlate child development and other factors. Read More

View Article and Full-Text PDF

Number symbols are processed more automatically than nonsymbolic numerical magnitudes: Findings from a Symbolic-Nonsymbolic Stroop task.

Acta Psychol (Amst) 2022 Jun 21;228:103644. Epub 2022 Jun 21.

Department of Psychology, Brain and Mind Institute, University of Western Ontario. London, Ontario, Canada.

Are number symbols (e.g., 3) and numerically equivalent quantities (e. Read More

View Article and Full-Text PDF

Evaluation of effect of septoplasty on nasal mucosal dryness using intranasal Schirmer test.

Acta Otolaryngol 2022 Jun 24:1-4. Epub 2022 Jun 24.

Department of Otorhinolaryngology, Head and Neck Surgery, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Background: Septal deviation causes the air entering the nose to encounter resistance and leads to turbulent flow formation by disrupting laminar air flow. In the literature, the Schirmer test has been recommended to evaluate the moistening of the nasal mucosa.

Aims/objectives: The purpose of this study was to evaluate the degree of nasal humidification using the intranasal schirmer test in patients with septal deviation and to reveal changes in mucosal dryness and humidity in both nasal cavities following septoplasty surgery. Read More

View Article and Full-Text PDF

Establishing a sustainable training programme in anaesthesia in Ethiopia.

Acta Anaesthesiol Scand 2022 Jun 24. Epub 2022 Jun 24.

Department of Surgical Services, Haukeland University Hospital, Bergen, Norway.

Background: Lack of qualified staff is a major hindrance for quality and safety improvements in anaesthesia and critical care in many low-income-countries. Support in specialist training may enhance perioperative treatment and have a positive downstream impact on other hospital services, which may improve the overall standard of care.

Methods: Between 2011 and 2019, consultant anaesthetists from Haukeland University Hospital in Norway supported a postgraduate anaesthesia-training programme at Addis Ababa University / Tikur Anbessa Specialized Hospital in Ethiopia. Read More

View Article and Full-Text PDF

Long-term effects of lower versus higher oxygenation levels in adult ICU patients - a systematic review.

Acta Anaesthesiol Scand 2022 Jun 24. Epub 2022 Jun 24.

Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.

Background: Oxygen therapy is a common treatment in the intensive care unit (ICU) with both potentially desirable and undesirable long-term effects. This systematic review aimed to assess the long-term outcomes of lower versus higher oxygenation strategies in adult ICU survivors.

Methods: We included randomised clinical trials (RCTs) comparing lower versus higher oxygen supplementation or oxygenation strategies in adults admitted to the ICU. Read More

View Article and Full-Text PDF

α-Synuclein molecular behavior and nigral proteomic profiling distinguish subtypes of Lewy body disorders.

Acta Neuropathol 2022 Jun 24. Epub 2022 Jun 24.

Tanz Centre for Research in Neurodegenerative Disease (CRND), University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON, M5T 0S8, Canada.

Lewy body disorders (LBD), characterized by the deposition of misfolded α-synuclein (α-Syn), are clinically heterogeneous. Although the distribution of α-Syn correlates with the predominant clinical features, the burden of pathology does not fully explain the observed variability in clinical presentation and rate of disease progression. We hypothesized that this heterogeneity might reflect α-Syn molecular diversity, between both patients and different brain regions. Read More

View Article and Full-Text PDF

Serum S100B correlates with health-related quality of life and functional outcome in patients at 1 year after aneurysmal subarachnoid haemorrhage.

Acta Neurochir (Wien) 2022 Jun 24. Epub 2022 Jun 24.

Department of Clinical Sciences - Neurosciences, Umeå University, 901 87, Umeå, Sweden.

Background: Early, objective prognostication after aneurysmal subarachnoid haemorrhage (aSAH) is difficult. A biochemical marker would be desirable. Correlation has been found between levels of the protein S100 beta (S100B) and outcome after aSAH. Read More

View Article and Full-Text PDF

Longitudinal changes in inflammatory biomarkers among patients with COVID-19: a nationwide study in Iceland.

Acta Anaesthesiol Scand 2022 Jun 24. Epub 2022 Jun 24.

Landspitali-The National University Hospital of Iceland, Hringbraut, 101 Reykjavík, Iceland.

Objectives: All SARS-CoV-2-positive persons in Iceland were prospectively monitored and those who required outpatient evaluation or were admitted to hospital underwent protocolized evaluation that included a standardized panel of biomarkers. The aim was to describe longitudinal changes in inflammatory biomarkers throughout the infection period of patients with COVID-19 requiring different levels of care.

Design: Registry-based study SETTING: Nationwide study in Iceland PATIENTS: All individuals who tested positive for SARS-CoV-2 by real-time polymerase chain reaction (RT-PCR) from 28 February to 31 December 2020 in Iceland and had undergone blood tests between five days prior to and 21 days following onset of symptoms. Read More

View Article and Full-Text PDF

Safety and efficacy of MRI-guided transurethral ultrasound ablation for radiorecurrent prostate cancer in the presence of gold fiducial markers.

Acta Radiol 2022 Jun 24:2841851221108292. Epub 2022 Jun 24.

Department of Diagnostic Radiology, 60652Turku University Hospital, Turku, Finland.

Background: Safety and efficacy of ultrasound prostate ablation for radiorecurrent prostate cancer (PCa) in the presence of gold fiducial markers has not been previously reported.

Purpose: To evaluate safety, functional, and early-stage oncological outcomes for patients with gold fiducial markers undergoing salvage magnetic resonance imaging (MRI)-guided transurethral ultrasound ablation (sTULSA) for radiorecurrent PCa.

Material And Methods: Data were acquired from an ethics-approved, single-center phase-1 study. Read More

View Article and Full-Text PDF

Being affiliated to a cystic fibrosis centre is important for parents' everyday life.

Acta Paediatr 2022 Jun 24. Epub 2022 Jun 24.

Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Denmark.

Aim: Newborn screening represents a paradigm shift in the treatment of children with cystic fibrosis. This study aimed to explore parents' everyday life experiences from the time of diagnosis and in the following months.

Methods: Narrative interviews were conducted at Aarhus University Hospital, Denmark, with parents (mothers = 15 and fathers =14) of 15 term-born children with a mean age of two weeks (range 1-3. Read More

View Article and Full-Text PDF

Mild coronary artery dilatation developed in some children with mild COVID-19 but completely regressed within 3 months.

Acta Paediatr 2022 Jun 24. Epub 2022 Jun 24.

Department of Pediatrics, University Hospital Heraklion, School of Medicine, University of Crete, Greece.

Aim: We studied the incidence and time course of any coronary artery changes in children up to 2 years of age who were hospitalised with mild COVID-19.

Methods: This was a single centre prospective study of 29 children (19 males) with a median age of 3.0 months and interquartile range (IQR) of 1. Read More

View Article and Full-Text PDF

Waterbirths were associated with low pain relief during delivery, high breastfeeding success and healthy newborn infants.

Acta Paediatr 2022 Jun 24. Epub 2022 Jun 24.

Department of Paediatrics, Tampere University Hospital, Tampere, Finland.

Aim: Our aim was to compare the outcomes of waterbirths and conventional births in a Finnish hospital setting for the first time.

Methods: This retrospective study compared waterbirths with conventional low-risk deliveries from September 2018 to March 2021 at a level-two hospital in Finland. Cases and controls were collected from the patient records database. Read More

View Article and Full-Text PDF

Surgical Resection Combined with Adjuvant Radiotherapy and Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Heterotopic Ossification Following Total Hip Arthroplasty.

Acta Med Port 2022 Jun 24. Epub 2022 Jun 24.

Orthopaedics Department. Hospital José Joaquim Fernandes. Unidade Local de Saúde do Baixo Alentejo. Beja. Portugal.

Heterotopic ossification (HO) is a well-known complication following total hip arthroplasty (THA), with an average incidence of 30%. Patients are classified according to Brooker's staging system. In advanced stages (III and IV), HO may limit hip motion and cause intolerable pain. Read More

View Article and Full-Text PDF

Long term cognitive and functional status in Danish ICU patients with COVID-19.

Acta Anaesthesiol Scand 2022 Jun 23. Epub 2022 Jun 23.

Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Koege, Denmark.

Background: ICU admission due to COVID-19 may result in cognitive and physical impairment. We investigated the long-term cognitive and physical status of Danish ICU patients with COVID-19.

Methods: We included all patients with COVID-19 admitted to Danish ICUs between March 10 and May 19 , 2020. Read More

View Article and Full-Text PDF

Ectopic TSH-secreting Pituitary Adenoma in Nasopharyngeal Region.

Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):521-527

Department of Radiology, Department of Endocrinology and Metabolism, Meram, Konya, "Pamukkale" University, Faculty of Medicine, Denizli, Turkey.

Objective: TSH-secreting pituitary adenomas (TSH-omas) are very rare disorders. This report describes the diagnosis and treatment of a thyroid-stimulating hormone-secreting ectopic pituitary adenoma in the nasopharyngeal region.

Subjects And Methods: We report a 37-year-old male patient with thyroid-stimulating hormone-secreting ectopic pituitary adenoma in nasopharyngeal region. Read More

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):479-485

Division of Endocrinology, Akdeniz University, School of Medicine, Antalya, Turkey.

Objective: Unilateral adrenalectomy (UA) is an alternative for treatment in bilateral adrenal incidentaloma (AI) to avoid possible long-term risks of bilateral adrenalectomy. In this study, we aimed to evaluate the effectiveness of UA in bilateral AI patients with subclinical hypercortisolemia (SH).

Method: A total of 35 patients were included in this study. Read More

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):427-431

"Iuliu Hatieganu" University of Medicine and Pharmacy - Diabetes, Nutrition and Metabolic Diseases, Cluj-Napoca, Romania.

Context: Obesity is a complex and heterogeneous disorder with multiple phenotypes described. Although metabolomic biomarkers of obesity have been extensively studied, biomarkers of obesity phenotypes and differences between these phenotypes and normal-weight (NW) persons have been less investigated.

Objective: The objective of this cross-sectional analysis was to investigate serum amino acids (AA) as markers of metabolic alterations in obesity phenotypes and NW. Read More

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):537-542

University of California San Diego, La Jolla, California, United States of America.

We describe clinical features of women with extremely low bone density, and investigate secondary causes of osteoporosis. Our hypothesis was that this population would be enriched in identifiable causes of osteoporosis. We performed a retrospective review of medical records of all women seen at our university over 4 years with T-score on bone densitometry at/below -4 at any site. Read More

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):552-553

Hangzhou Normal University Affiliated Hospital - Department of Thyroid and Breast Surgery, Hangzhou, Zhejiang, China.

View Article and Full-Text PDF


Acta Endocrinol (Buchar) 2021 Oct-Dec;17(4):455-461

Dept. of Pathology, Trakya University, Faculty of Medicine, Ankara, Turkey.

Context: Papillary thyroid carcinoma(PTC)s are the indolent progressive tumours. Survivin is a unique bifunctional protein with cell cycle regulation and apoptosis inhibition. The expression of this protein has been shown to be increased in thyroid tumours correlated with aggressive behavior from well differentiated to anaplastic. Read More

View Article and Full-Text PDF