761 results match your criteria Acs Sensors[Journal]


Introducing Our Authors.

Authors:
Sue Min Liu

ACS Sens 2018 Sep;3(9):1610

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http://dx.doi.org/10.1021/acssensors.8b00958DOI Listing
September 2018

Combination of double-mediator system with large-scale integration-based amperometric devices for detecting NAD(P)H:quinone oxidoreductase 1 activity of cancer cell aggregates.

ACS Sens 2019 Apr 17. Epub 2019 Apr 17.

NAD(P)H:quinone oxidoreductase 1 (NQO1) is a key enzyme providing cytoprotection from quinone species. In addition, it is expressed at high levels in many human tumors, such as breast cancer. Therefore, it is considered to be a potential target in cancer treatment. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00344
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http://dx.doi.org/10.1021/acssensors.9b00344DOI Listing
April 2019
1 Read

Nanopores for Sensing.

ACS Sens 2018 Dec;3(12):2471-2472

The University of New South Wales , Sydney , Australia.

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http://dx.doi.org/10.1021/acssensors.8b01501DOI Listing
December 2018

Ultrasensitive Detection of Hepatotoxic Microcystin Production from Cyanobacteria Using Surface-Enhanced Raman Scattering (SERS) Immunosensor.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

Microcystin-LR (MC-LR) is considered the most common hazardous toxin produced during harmful algal blooms. In addition to potential risk of long-term exposure to low concentrations in drinking water, acute toxicity due to MC-LR resulting from algal blooms could result in fatalities in rare cases. Although several methods are currently available to detect MC-LR, development of a low-cost, ultrasensitive measurement method would help limit exposure by enabling early detection and continuous monitoring of MC-LR. Read More

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http://dx.doi.org/10.1021/acssensors.8b01453DOI Listing

Redox-based synthetic biology enables electrochemical detection of the herbicides dicamba and RoundupTM via rewired Escherichia coli.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

Synthetic biology is typically exploited to endow bacterial cells with new biosynthetic capabilities. It can also serve to create "smart" bacteria such as probiotics that detect and treat disease. Here, we show how minimally rewiring the genetic regulation of bacterial cells can enable their ability to recognize and report on chemical herbicides, including those routinely used to clear weeds from gardens and crops. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00085
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http://dx.doi.org/10.1021/acssensors.9b00085DOI Listing
April 2019
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The improvement of gas and humidity sensing properties of organ-like MXene by alkaline treatment.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

Ti3C2Tx MXene with an organ-like structure was synthesized from Ti3AlC2 (MAX phase) through the typical hydrofluoric (HF) acid etching method. Ti3C2Tx MXene was further alkaline-treated with a sodium hydroxide solution to obtain alkalized Ti3C2Tx. Room-temperature planar-type gas and humidity-sensing devices were also fabricated by utilizing Ti3C2Tx MXene and alkalized Ti3C2Tx sensing material based on the dip coating method, respectively. Read More

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http://dx.doi.org/10.1021/acssensors.9b00127DOI Listing

Quiet Outer Membrane Protein G (OmpG) Nanopore for Biosensing.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

Interest in nanopore technology has been growing due to their unique capabilities in small molecule sensing, measurement of protein folding, and low-cost DNA and RNA sequencing. The E. coli β-barrel outer membrane protein OmpG is an excellent alternative to other protein nanopores because of its single polypeptide chain. Read More

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http://dx.doi.org/10.1021/acssensors.8b01645DOI Listing

Porous hydrogel encapsulated photonic barcodes for multiplex detection of cardiovascular biomarkers.

ACS Sens 2019 Apr 15. Epub 2019 Apr 15.

Early detection of cardiac troponin I (cTnI), B-type natriuretic peptide (BNP), and myoglobin (Myo) is essential for the diagnosis of acute myocardial infarction (AMI) and heart failure (HF). We designed a porous hydrogel-encapsulated photonic crystal (PhC) barcode-based suspension array for multiple cardiovascular marker detection. The hybrid hydrogel was composed of poly ethylene glycol diacrylate (PEGDA) and gelatin, resulting in a porous and hydrophilic scaffold which ensured stability of the PhC in aqueous solutions. Read More

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http://dx.doi.org/10.1021/acssensors.9b00352DOI Listing

Electrodes for membrane surface science. Bilayer lipid membranes tethered by commercial surfactants on electrochemical sensors.

ACS Sens 2019 Apr 12. Epub 2019 Apr 12.

Commercial surfactants, inexpensive and abundant, were covalently grafted to flat and transparent electrodes and it appears to be a simple functionalization route to design bio-membrane sensors at large scale production. Sparsely tethered bilayer lipid membranes (stBLM) were stabilized from such molecular coatings composed of diluted anchor-harpoon surfactants that grab the membrane with an alkyl chain out of a PEGylated-hydrogel layer which acts as a soft hydration cushion. Avoiding the synthesis of complex organic molecules to scale up sensors realization was achieved here by grafting non-ionic diblock oligo-mers (Brij58: CxH2x+1(OCH2CH2)nOH with x=16 and n=23), as well as PEO short chains ((OCH2CH2)nOH with n=9 and n=23) from their hydroxyl (-OH) end-moiety to a monolayer of -Ar-SO2Cl groups, easy to form on electrodes (metals, semi-conducting materials, …) from aryl-diazonium salts reduction. Read More

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http://dx.doi.org/10.1021/acssensors.9b00267DOI Listing
April 2019
2 Reads

DNA-based photoacoustic nanosensor for interferon gamma detection.

ACS Sens 2019 Apr 11. Epub 2019 Apr 11.

Tracking protein levels in the body is vital in both research and medicine, where understanding their physiological roles provides insight into their regulation in homeostasis and diseases. In medicine, protein levels are actively sampled since they continuously fluctuate, reflecting the status of biological systems and providing insight into patient health. One such protein is interferon gamma, a clinically relevant protein with immunoregulatory functions that play critical roles against infections. Read More

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http://dx.doi.org/10.1021/acssensors.9b00209DOI Listing

A 3D Capillary-Driven Paper-Based Sequential Microfluidic Device for Electrochemical Sensing Applications.

ACS Sens 2019 Apr 10. Epub 2019 Apr 10.

This article describes the device design and fabrication of two different configurations (flow-through and stopped-flow) of a sequential fluid delivery platform on a microfluidic paper-based device. The developed device is capable of storing and transporting reagents sequentially to the detection channel without the need for external power. The device comprises two components: an origami folding paper (oPAD) and a movable reagent-stored pad (rPAD). Read More

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http://dx.doi.org/10.1021/acssensors.8b01574DOI Listing

Amperometric detection of the urinary disease biomarker p-HPA by allosteric modulation of a redox polymer-embedded bacterial reductase.

ACS Sens 2019 Apr 10. Epub 2019 Apr 10.

We report an amperometric biosensor for the urinary disease biomarker para-hydroxyphenyl-acetate (p-HPA) in which the allosteric reductase component of a bacterial hydroxylase, C1-hpah, is electrically wired to glassy carbon electrodes through incorporation into a low-potential Os-complex modified redox polymer. The proposed biosensing strategy depends on allosteric modulation of C1-hpah by the binding of the enzyme activator and analyte p-HPA, stimulating oxidation of the cofactor NADH. The pronounced concentration-dependence of allosteric C1-hpah modulation in the presence of a constant concentration of NADH allowed sensitive quan-tification of the target, p-HPA. Read More

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http://dx.doi.org/10.1021/acssensors.9b00144DOI Listing
April 2019
2 Reads

Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis Toward Autonomous Decision Making.

ACS Sens 2019 Apr 9. Epub 2019 Apr 9.

Microphysiological systems replicate human organ function, and are promising technologies for discovery of translatable biomarkers, pharmaceuticals, and regenerative therapies. Because microphysiological systems require complex microscale anatomical structures and heterogeneous cell populations, a major challenge remains to manufacture and operate these products with reproducible and standardized function. In this Perspective, three stages of microphysiological system monitoring, including process, development, and function, are assessed. Read More

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http://dx.doi.org/10.1021/acssensors.8b01549DOI Listing

Decoding the Time-Dependent Response of Bioluminescent Metal-Detecting Whole-Cell Bacterial Sensors.

ACS Sens 2019 Apr 9. Epub 2019 Apr 9.

The signal produced by aqueous dispersions of bioluminescent, metal-responsive whole-cell bacterial sensors is indicative of the concentration of bioavailable metal ions in solution. The conventional calibration-based strategy followed for measuring this concentration is however inadequate to provide any quantitative prediction of the cells response over time as a function of e.g. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00349
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http://dx.doi.org/10.1021/acssensors.9b00349DOI Listing
April 2019
1 Read

3D-printed point-of-care platform for genetic testing of infectious diseases directly in human samples using acoustic sensors and a smartphone.

ACS Sens 2019 Apr 9. Epub 2019 Apr 9.

The objective of this work is to develop a methodology and associated platform for nucleic acid detection at the point-of-care (POC) that is sensitive, user-friendly, affordable, rapid and robust. The heart of this system is an acoustic wave sensor, based on a Surface Acoustic Wave (SAW) or Quartz Crystal Microbalance (QCM) device, which is employed for the label-free detection of isothermally amplified target DNA. Nucleic acids amplification and detection is demonstrated inside three crude human samples, i. Read More

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http://dx.doi.org/10.1021/acssensors.9b00264DOI Listing

Flexible Biosensors for the Impedimetric Detection of Protein Targets Using Silk-Conductive Polymer Biocomposites.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemical and Life Science Engineering , Virginia Commonwealth University , 601 W. Main Street , Richmond , Virginia 23284 , United States.

To expand the applications of flexible biosensors in point-of-care healthcare applications beyond monitoring of biophysical parameters, it is important to devise strategies for the detection of various proteins and biomarkers. Here, we demonstrate a flexible, fully organic, biodegradable, label-free impedimetric biosensor for the critical biomarker, vascular endothelial growth factor (VEGF). This biosensor was constructed by photolithographically patterning a conducting ink consisting of a photoreactive silk sericin coupled with a conducting polymer. Read More

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http://dx.doi.org/10.1021/acssensors.9b00230DOI Listing

Top-Down Strategy of Implantable Biosensor Using Adaptable, Porous Hollow Fibrous Membrane.

ACS Sens 2019 Apr 16. Epub 2019 Apr 16.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.

Fabrication of an outer membrane is crucial for an implantable biosensor to enhance the long-term stability and accuracy of sensors. Herein, an adaptable, controllable, porous outer membrane for an implantable biosensor was fabricated using a "top-down" method, allowing maximum retention of enzyme activity and fine control over membrane microstructure. Polysulfone hollow fibrous membranes with different pore sizes and porosities were used as a base membrane. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00035
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http://dx.doi.org/10.1021/acssensors.9b00035DOI Listing
April 2019
7 Reads

Development of a Minimally Invasive Microneedle-Based Sensor for Continuous Monitoring of β-Lactam Antibiotic Concentrations in Vivo.

ACS Sens 2019 Apr 17. Epub 2019 Apr 17.

Department of Bioengineering , Imperial College London , London SW7 2AZ , United Kingdom.

Antimicrobial resistance poses a global threat to patient health. Improving the use and effectiveness of antimicrobials is critical in addressing this issue. This includes optimizing the dose of antibiotic delivered to each individual. Read More

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http://dx.doi.org/10.1021/acssensors.9b00288DOI Listing
April 2019
1 Read

Advanced Colorimetric Paper Sensors Using Color Focusing Effect Based on Asymmetric Flow of Fluid.

ACS Sens 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemistry, School of Physics and Chemistry , Gwangju Institute of Science and Technology (GIST) , Gwangju 61005 , Republic of Korea.

Although paper-based colorimetric sensors utilizing enzymatic reactions are well suited for real-field diagnosis, their widespread use is hindered by signal blurring at the detection spot due to the action of capillary forces on the liquid and the corresponding membrane. In this study, we eliminated signal losses commonly observed during enzyme-mediated colorimetric sensing and achieved pattern-free quantitative analysis of glucose and uric acid by mixing enzymes and color-forming reagents with chitosan oligosaccharide lactate (COL), which resulted in perfectly focused colorimetric signals at the detection spot, using asymmetric flow induced by changing the flow rate of the COL-treated paper. The targets were calibrated with 0-500 mg/dL of glucose and 0-200 mg/dL of uric acid, and the limit of detection was calculated to be 0. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00390
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http://dx.doi.org/10.1021/acssensors.9b00390DOI Listing
April 2019
2 Reads

Dual Mode Chip Enantioselective Express Discrimination of Chiral Amines via Wettability-Based Mobile Application and Portable Surface-Enhanced Raman Spectroscopy Measurements.

ACS Sens 2019 Apr 15. Epub 2019 Apr 15.

Department of Solid State Engineering , University of Chemistry and Technology , 16628 Prague , Czech Republic.

A dual-mode functional chip for chiral sensing based on mobile phone wettability measurements and portable surface-enhanced Raman spectroscopy (SERS) is reported. The plasmon-active regular gold grating surface was covalently grafted with chiral recognition moieties, l- or d-enantiomers of tartaric acid, making stereoselective discrimination of chiral amines possible. Chiral sensing of amines includes two modes of analysis, performed subsequently on the one chip surface with portable instruments (mobile phone equipped with a camera and developed application (app) Dropangle and a portable Raman spectrometer). Read More

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http://dx.doi.org/10.1021/acssensors.9b00225DOI Listing

One-Component Array Based on a Dansyl-Modified Polylysine: Generation of Differential Fluorescent Signatures for the Discrimination of Human Cells.

ACS Sens 2019 Apr 8. Epub 2019 Apr 8.

Biomedical Research Institute , National Institute of Advanced Industrial Science and Technology , 1-1-1 Higashi , Tsukuba , Ibaraki 305-8566 , Japan.

A one-component array-based sensor consisting of a dansyl-modified polylysine (PLL-Dnc) is capable of discriminating the types and compositional ratios of human cells using varying buffer conditions. The PLL-Dnc sensor array, which affords turn-on fluorescence responses against analyte cells that depend on the pH value and the ionic strength, generates differential fluorescence signatures of cells and successfully discriminates eight types of human cell lines (2.0 × 10 cells/mL) with 100% accuracy using multivariate analysis. Read More

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http://dx.doi.org/10.1021/acssensors.9b00247DOI Listing

Label-Free Telomerase Detection in Single Cell Using a Five-Base Telomerase Product-Triggered Exponential Rolling Circle Amplification Strategy.

ACS Sens 2019 Apr 12. Epub 2019 Apr 12.

State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Biosensing and Molecular Recognition, Research Center for Analytical Sciences, College of Chemistry , Nankai University , Tianjin , 300071 , P. R. China.

Telomerase is a universal biomarker of malignant tumors. Sensitive and reliable analysis for telomerase activity is of vital importance for both early diagnosis and therapy of malignant tumors. Herein, a novel fluorescent strategy was proposed for sensitive and label-free detection of telomerase activity. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00334
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http://dx.doi.org/10.1021/acssensors.9b00334DOI Listing
April 2019
2 Reads

Porous Nanophotonic Optomechanical Beams for Enhanced Mass Adsorption.

ACS Sens 2019 Apr 3. Epub 2019 Apr 3.

We have developed a porous silicon nanocantilever for a nano-optomechanical system (NOMS) with a universal sensing surface for enhanced sensitivity. Using electron beam lithography, we selectively applied a V2O5/HF stain etch to the mechanical elements while protecting the silicon-on-insulator photonic ring resonators. This simple, rapid, and electrodeless approach generates tunable device porosity simultaneously with the mechanical release step. Read More

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http://dx.doi.org/10.1021/acssensors.8b01366DOI Listing

Amplification-by-Polymerization in Biosensing for Human Genomic DNA Detection.

ACS Sens 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemistry , North Carolina State University , Raleigh , North Carolina 27695 , United States.

A polymerization reaction was employed as a signal amplification method to realize direct visualization of gender-specific DNA extracted from human blood in a polymerase chain reaction (PCR)-free fashion. Clear distinction between X and Y chromosomes was observed by naked eyes for detector-free sensing purposes. The grown polymer films atop X and Y chromosomes were quantitatively measured by ellipsometry for thickness readings. Read More

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http://dx.doi.org/10.1021/acssensors.9b00133DOI Listing
April 2019
1 Read

A Dual-Signal Twinkling Probe for Fluorescence-SERS Dual Spectrum Imaging and Detection of miRNA in Single Living Cell via Absolute Value Coupling of Reciprocal Signals.

ACS Sens 2019 Apr 10. Epub 2019 Apr 10.

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE; State Key Laboratory Base for Eco-chemical Engineering; Shandong Key Laboratory of Biochemical Analysis; Key Laboratory of Analytical Chemistry for Life Science in Universities of Shandong; College of Chemistry and Molecular Engineering . Qingdao University of Science and Technology , Qingdao 266042 , PR China.

Imaging and detecting microRNAs (miRNAs) is of central importance in tumor cell analysis. It stays challenging to establish simple, accurate, and sensitive analytical assays for imaging and detection of miRNA in a single living cell, because of intracellular complex environment and miRNA sequence similarity. Herein, we designed a dual-signal twinkling probe (DSTP) with triplex-stem structure which employed a fluorescence-SERS signal reciprocal switch. Read More

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http://dx.doi.org/10.1021/acssensors.9b00031DOI Listing

Defect Sites Modulate Fouling Resistance on Carbon-Nanotube Fiber Electrodes.

ACS Sens 2019 Apr 9. Epub 2019 Apr 9.

Department of Chemistry , University of Cincinnati , 404 Crosley Tower, 312 College Dr. , Cincinnati , Ohio 45221-0172 , United States.

Carbon nanotube (CNT) fiber electrodes have become increasingly popular electrode materials for neurotransmitter detection with fast-scan cyclic voltammetry (FSCV). The unique properties of CNT fiber electrodes like increased electron transfer, sensitivity, waveform application frequency independence, and resistance to fouling make them ideal biological sensors for FSCV. In particular, their resistance to fouling has been observed for several years, but the specific physical properties which aid in fouling resistance have been debated. Read More

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http://dx.doi.org/10.1021/acssensors.9b00161DOI Listing

Rapid Capture and Non-destructive Release of Extracellular Vesicles using Aptamer-based Magnetic Isolation.

ACS Sens 2019 Mar 27. Epub 2019 Mar 27.

Extracellular vesicles (EVs) play important roles in cell-cell communication by transferring cargo proteins and nucleic acids between cells. Due to the small size (50-150 nm) and low density, rapid capture and non-destructive release of EVs remains a technical challenge, which significantly hinder its bio-function study and biomedical application. To address this issue, we designed a DNA aptamer-based system that enable rapid capture and non-destructive release of EVs in 90 mins, with isolation efficiency similar to ultracentrifugation (around 78%). Read More

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http://dx.doi.org/10.1021/acssensors.9b00060DOI Listing

Specific Fluorescent Probe for Protein Histidine Phosphatase Activity.

ACS Sens 2019 Apr 3. Epub 2019 Apr 3.

Protein histidine phosphorylation plays a vital role in cell signaling and metabolic processes, and phosphohistidine (pHis) phosphatases such as protein histidine phosphatase 1 (PHPT1) and LHPP have been linked to cancer and diabetes, making them novel drug targets and biomarkers. Unlike the case for other classes of phosphatases, further studies of PHPT1 and other pHis phosphatases have been hampered by the lack of specific activity assays in complex biological mixtures. Previous methods relying on radiolabeling are hazardous and technically laborious, and small-molecule phosphatase probes are not selective toward pHis phosphatases. Read More

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http://dx.doi.org/10.1021/acssensors.9b00242DOI Listing

Light-Regulated Electrochemical Reaction Assisted Core-Shell Heterostructure for Detecting Specific Volatile Markers with Controllable Sensitivity and Selectivity.

ACS Sens 2019 Apr 5. Epub 2019 Apr 5.

Qi Diagnostics Ltd , Hongkong , P. R. China.

Breath analysis has been considered a noninvasive, safe, and reliable way to diagnose cancer at very early stage. Rapid detection of cancer volatile markers in breath samples via a portable sensing device will lay the foundation of future early cancer diagnosis. Nevertheless, unsatisfactory sensitivity and specificity of these sensing devices restrain the clinical application of breath analysis. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00289
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http://dx.doi.org/10.1021/acssensors.9b00289DOI Listing
April 2019
7 Reads

Pathogenic Bacteria Detection Using RNA-Based Loop-Mediated Isothermal-Amplification-Assisted Nucleic Acid Amplification via Droplet Microfluidics.

ACS Sens 2019 Mar 25. Epub 2019 Mar 25.

Department of Food Science, College of Agricultural and Life Sciences , Cornell University , Ithaca , New York 14853 , United States.

Nucleic acid amplifications, such as polymerase chain reaction (PCR), are very beneficial for diagnostic applications, especially in the context of bacterial or viral outbreaks due to their high specificity and sensitivity. However, the need for bulky instrumentation and complicated protocols makes these methods expensive and slow, particularly for low numbers of RNA or DNA templates. In addition, implementing conventional nucleic acid amplification in a high-throughput manner is both reagent- and time-consuming. Read More

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http://dx.doi.org/10.1021/acssensors.8b01206DOI Listing

Trace Detection of Tetrahydrocannabinol in Body Fluid via Surface-Enhanced Raman Scattering and Principal Component Analysis.

ACS Sens 2019 Apr 2. Epub 2019 Apr 2.

Tetrahydrocannabinol (THC) is the main active component in marijuana and the rapid detection of THC in human body fluid plays a critical role in forensic analysis and public health. Surface-enhanced Raman scattering (SERS) sensing has been increasingly used to detect illicit drugs; however, only limited SERS sensing results of THC in methanol solution have been reported, while its presence in body fluids, such as saliva or plasma, has yet to be investigated. In this article, we demonstrate the trace detection of THC in human plasma and saliva solution using a SERS-active substrate formed by in situ growth of silver nanoparticles (Ag NPs) on diatom frustules. Read More

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http://dx.doi.org/10.1021/acssensors.9b00476DOI Listing
April 2019
3 Reads

Ratiometric Fluorescent Hydrogel Test Kit for On-Spot Visual Detection of Nitrite.

ACS Sens 2019 Apr 3. Epub 2019 Apr 3.

Institute of Nanomedicine and Nanobiosensing, MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry , Fuzhou University , Fuzhou 350116 , China.

In this work, we proposed a new method based on carbon dots (named m-CDs) for selective and efficient detection of nitrite (NO), which was based on the interaction between the amine group of m-CDs and NO via a diazo reaction that produced diazonium salts and induced the fluorescence quenching of m-CDs. The concentration of NO shows a good linear relationship with a quenched fluorescence intensity from 0.063 to 2. Read More

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http://dx.doi.org/10.1021/acssensors.9b00125DOI Listing

Label-Free Optical Detection of Multiple Biomarkers in Sweat, Plasma, Urine, and Saliva.

ACS Sens 2019 Apr 2. Epub 2019 Apr 2.

Nanoelectronics Laboratory , University of Cincinnati , Cincinnati , Ohio 45221-0030 , United States of America.

We report a novel label-free quantitative detection of human performance "stress" biomarkers in different body fluids based on optical absorbance of the biomarkers in the ultraviolet (UV) region. Stress biomarker (hormones and neurotransmitters) concentrations in bodily fluids (blood, sweat, urine, saliva) predict the physical and mental state of the individual. The stress biomarkers primarily focused on in this manuscript are cortisol, serotonin, dopamine, norepinephrine, and neuropeptide Y. Read More

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http://dx.doi.org/10.1021/acssensors.9b00301DOI Listing

Mycobacterium tuberculosis strain H37Rv Electrochemical Sensor Mediated by Aptamer and AuNPs-DNA.

ACS Sens 2019 Mar 28. Epub 2019 Mar 28.

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering , Hunan University , Changsha , China , 410082.

The accurate and rapid detection of Mycobacterium tuberculosis ( M. tuberculosis) is essential for the effective treatment of tuberculosis. In this article, we propose an electrochemical sensor to detect M. Read More

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http://dx.doi.org/10.1021/acssensors.8b01230DOI Listing

Development of a "Dual Gates" Locked, Target-Triggered Nanodevice for Point-of-Care Testing with a Glucometer Readout.

ACS Sens 2019 Apr 2. Epub 2019 Apr 2.

College of Chemistry and Chemical Engineering , Central South University , Changsha 410083 , Hunan , China.

Developing a facile and sensitive sensing platform is of importance for point-of-care testing (POCT). Herein, a sensitive and portable POCT platform based on "dual gates" aminated magnetic mesoporous silica nanocomposites (AMMS) bearing polydopamine (PDA)-aptamer (Apt) two-tier shells, as a novel nanodevice, is designed for target detection through a target-triggered glucose (GO) release from AMMS with personal glucometer (PGM) readout. In the absence of target, GO can be firmly captured in pores by the designed "dual gates", which would decrease the high background signal of this system and ensure the accuracy of the detection results. Read More

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http://dx.doi.org/10.1021/acssensors.9b00072DOI Listing

What Does Ultrasensitive Really Mean?

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ACS Sens 2019 Mar;4(3):528

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http://dx.doi.org/10.1021/acssensors.9b00404DOI Listing

Rapidly Visualizing the Membrane Affinity of Gene Vectors Using Polydiacetylene-Based Allochroic Vesicles.

ACS Sens 2019 Mar 21. Epub 2019 Mar 21.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering , Nanjing University , Nanjing 210023 , China.

The high-throughput screening of chemically active substances has aroused widespread interest in recent years. The screening of drug carriers is usually ignored, although they interact directly with physiological barriers and target cells, and they determine the fate and efficacy of drugs in vivo. In this work, a series of polydiacetylene (PDA) vesicles (ca. Read More

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http://dx.doi.org/10.1021/acssensors.9b00102DOI Listing

Noble Metal Nanoparticle-Based Multicolor Immunoassays: An Approach toward Visual Quantification of the Analytes with the Naked Eye.

ACS Sens 2019 Apr 4. Epub 2019 Apr 4.

School of Chemistry and Chemical Engineering, Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province , Gannan Normal University , Ganzhou , 341000 , China.

Noble metal nanoparticle-based colorimetric sensors have become powerful tools for the detection of different targets with convenient readout. Among the many types of nanomaterials, noble metal nanoparticles exhibit extraordinary optical responses mainly due to their excellent localized surface plasmon resonance (LSPR) properties. The absorption spectrum of the noble metal nanoparticles was mostly in the visible range. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00438
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http://dx.doi.org/10.1021/acssensors.9b00438DOI Listing
April 2019
5 Reads

Easy Diagnosis of Jaundice: A Smartphone-Based Nanosensor Bioplatform Using Photoluminescent Bacterial Nanopaper for Point-of-Care Diagnosis of Hyperbilirubinemia.

ACS Sens 2019 Mar 29. Epub 2019 Mar 29.

Chemistry and Chemical Engineering Research Center of Iran , 14335-186 , Tehran , Iran.

One of the concerns of parents in the first days of their baby's birth is the baby's risk of jaundice/hyperbilirubinemia. This is because more than 60% of babies are born with jaundice that, if not timely diagnosed and subsequently treated, can lead to serious damage to their health. On the other hand, despite recent progress in sensor technology for clinical applications, the development of easy-to-use, cost-effective, sensitive, specific, and portable diagnostic devices, which use nontoxic and biodegradable materials in their design and fabrication, is still in high demand. Read More

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http://dx.doi.org/10.1021/acssensors.9b00275DOI Listing
March 2019
5 Reads

Distance and Color Change Based Hydrogel Sensor for Visual Quantitative Determination of Buffer Concentrations.

ACS Sens 2019 Mar 28. Epub 2019 Mar 28.

Department of Chemistry , Southern University of Science and Technology , Shenzhen , 518055 , China.

We present here an innovative platform for the determination of pH buffer capacity based on FITC-dextran loaded hydrogels. Optical signals from the pH-sensitive hydrogels were analyzed by simple parameters including distance and color change. The methodology was validated on five different buffer systems and exhibited wide linearity (0. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00186
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http://dx.doi.org/10.1021/acssensors.9b00186DOI Listing
March 2019
7 Reads

Colorimetric Detection of Salivary α-Amylase Using Maltose as a Noncompetitive Inhibitor for Polysaccharide Cleavage.

ACS Sens 2019 Apr 3. Epub 2019 Apr 3.

Center for Biomimetic Sensor Science, School of Materials Science and Engineering , Nanyang Technological University , Singapore , 639798.

This paper describes an approach for colorimetric detection of salivary α-amylase, one of the potential biomarkers of autonomic nervous system (ANS) activity, for enabling assessment of fatigue. The ability of α-amylase to cleave α-bonds of polysaccharides is utilized for developing a colorimetric assay. In the proposed approach, 2-chloro-4-nitrophenyl-α-d-maltotrioside as substrate releases a colored byproduct upon cleavage by salivary α-amylase. Read More

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http://dx.doi.org/10.1021/acssensors.8b01343DOI Listing
April 2019
1 Read

A Versatile Method to Enhance the Operational Current of Air-Stable Organic Gas Sensor for Monitoring of Breath Ammonia in Hemodialysis Patients.

ACS Sens 2019 Apr 1. Epub 2019 Apr 1.

Université de Haute-Alsace , CNRS, IS2M UMR 7361, F-68100 Mulhouse , France.

Point-of-care (POC) application for monitoring of breath ammonia (BA) in hemodialysis (HD) patients has emerged as a promising noninvasive health monitoring approach. In this context, many organic gas sensors have been reported for BA detection. However, one of the major challenges for its integration with affordable household POC application is to achieve stable performance for accuracy and high operational current at low voltage for low-cost read-out circuitry. Read More

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http://dx.doi.org/10.1021/acssensors.9b00223DOI Listing
April 2019
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Ultrafast and Ultrasensitive Naked-Eye Detection of Urease-Positive Bacteria with Plasmonic Nanosensors.

ACS Sens 2019 Mar 22. Epub 2019 Mar 22.

Multidisciplinary Sepsis Group , Balearic Islands Health Research Institute (IdISBa) , S Building, Son Espases Hospital , 07120 Palma de Mallorca , Illes Balears , Spain.

Identifying the pathogen responsible for an infection is a requirement in order to personalize antimicrobial treatments. Detecting bacterial enzymes, such as proteases, lipases, and oxidoreductases, is a winning approach for detecting pathogens at the point of care. In this Article, a new method for detecting urease-producing bacteria rapidly and at ultralow concentrations is reported. Read More

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http://dx.doi.org/10.1021/acssensors.9b00063DOI Listing
March 2019
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Porphyrinic Probe for Fluorescence "Turn-On" Monitoring of Cu in Aqueous Buffer and Mitochondria.

ACS Sens 2019 Mar 22. Epub 2019 Mar 22.

School of Medicine , Zhejiang University City College , Hangzhou , Zhejiang 310015 , People's Republic of China.

A zinc(II) porphyrin derivative (ZPSN) was designed and synthesized, and this probe exhibited rapid, selective and reversible binding to Cu for fluorescence monitoring in pure aqueous buffer. The detection mechanism is based on Cu-activated disruption of axial coordination between the pyridyl ligand and the zinc center, which changes the molecular geometry and inhibits intramolecular electron transfer (ET), leading to fluorescence enhancement of the probe. The proposed sensing mechanism was supported by UV-vis spectroscopy/fluorescence spectral titration, NMR spectroscopy, mass spectrometry, and time-resolved fluorescence decay studies. Read More

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http://dx.doi.org/10.1021/acssensors.8b01240DOI Listing

Measuring Binding Constants of Cucurbituril-Based Host-Guest Interactions at the Single-Molecule Level with Nanopores.

ACS Sens 2019 Mar 13;4(3):774-779. Epub 2019 Mar 13.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry , Chinese Academy of Sciences , Beijing 100190 , China.

Cucurbiturils are one type of widely used macrocyclic host compound in supramolecular chemistry. Their peculiar properties have led to applications in a wide variety of research areas such as fluorescence spectroscopy, drug delivery, catalysis, and nanotechnology. However, the solubilities of cucurbiturils are rather poor in water and many organic solvents, which may cause accuracy problems when measuring binding constants with traditional methods. Read More

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http://dx.doi.org/10.1021/acssensors.9b00408DOI Listing
March 2019
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SERS-Based Pump-Free Microfluidic Chip for Highly Sensitive Immunoassay of Prostate-Specific Antigen Biomarkers.

ACS Sens 2019 Mar 22. Epub 2019 Mar 22.

School of Materials Science and Engineering , Hefei University of Technology , Hefei 230009 , China.

Highly sensitive analysis of cancer biomarkers demonstrates an important impact in early diagnosis and therapies of cancer. A novel surface-enhanced Raman scattering (SERS) based immunoassay using microfluidic technique was reported for rapid analysis of prostate-specific antigen (PSA) biomarker. It is a useful screening test to discriminate prostate cancer and other diseases related to prostate. Read More

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http://dx.doi.org/10.1021/acssensors.9b00039DOI Listing
March 2019
2 Reads

pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments.

ACS Sens 2019 Mar 30. Epub 2019 Mar 30.

Molecular Biology and Biochemistry, Gottfried Schatz Research Center , Medical University of Graz , Neue Stiftingtalstraße 6/6 , 8010 Graz , Austria.

Distinct subcellular pH levels, especially in lysosomes and endosomes, are essential for the degradation, modification, sorting, accumulation, and secretion of macromolecules. Here, we engineered a novel genetically encoded pH probe by fusing the pH-stable cyan fluorescent protein (FP) variant, mTurquoise2, to the highly pH-sensitive enhanced yellow fluorescent protein, EYFP. This approach yielded a ratiometric biosensor-referred to as pH-Lemon-optimized for live imaging of distinct pH conditions within acidic cellular compartments. Read More

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http://dx.doi.org/10.1021/acssensors.8b01599DOI Listing

Intelligent Food Packaging: A Review of Smart Sensing Technologies for Monitoring Food Quality.

ACS Sens 2019 Mar 25. Epub 2019 Mar 25.

Leslie Dan Faculty of Pharmacy , University of Toronto , 144 College Street , Toronto , Ontario M5S 3M2 , Canada.

Food safety is a major factor affecting public health and the well-being of society. A possible solution to control food-borne illnesses is through real-time monitoring of the food quality throughout the food supply chain. The development of emerging technologies, such as active and intelligent packaging, has been greatly accelerated in recent years, with a focus on informing consumers about food quality. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00440
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http://dx.doi.org/10.1021/acssensors.9b00440DOI Listing
March 2019
7 Reads

Rapid and Fully Microfluidic Ebola Virus Detection with CRISPR-Cas13a.

ACS Sens 2019 Mar 21. Epub 2019 Mar 21.

Department of Chemistry , University of California, Berkeley , Berkeley , California 94720 , United States.

Highly infectious illness caused by pathogens is endemic especially in developing nations where there is limited laboratory infrastructure and trained personnel. Rapid point-of-care (POC) serological assays with minimal sample manipulation and low cost are desired in clinical practice. In this study, we report an automated POC system for Ebola RNA detection with RNA-guided RNA endonuclease Cas13a, utilizing its collateral RNA degradation after its activation. Read More

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http://dx.doi.org/10.1021/acssensors.9b00239DOI Listing

Detection of Single Proteins with a General Nanopore Sensor.

ACS Sens 2019 Mar 15. Epub 2019 Mar 15.

Key Laboratory for Advanced Materials, School of Chemistry & Molecular Engineering , East China University of Science and Technology , Shanghai , 200237 , P. R. China.

Single protein sensing based on solid-state nanopores is promising but challenging, because the fast translocation velocity of a protein is beyond the bandwidth of nanopore instruments. To decelerate the translocation speed, here, we employed a common protein cross-link interaction to achieve a general and robust nanopore sensing platform for single-molecule detection of protein. Benefiting from the EDC/NHS coupling interaction between nanopore and proteins, a 10-fold decrease in speed has been achieved. Read More

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http://pubs.acs.org/doi/10.1021/acssensors.9b00228
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http://dx.doi.org/10.1021/acssensors.9b00228DOI Listing
March 2019
5 Reads