749 results match your criteria Acs Central Science[Journal]


An Unconventional Iron Nickel Catalyst for the Oxygen Evolution Reaction.

ACS Cent Sci 2019 Mar 26;5(3):558-568. Epub 2019 Feb 26.

Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), EPFL-ISIC-LSCI, BCH 3305, Lausanne CH 1015, Switzerland.

The oxygen evolution reaction (OER) is a key process that enables the storage of renewable energies in the form of chemical fuels. Here, we describe a catalyst that exhibits turnover frequencies higher than state-of-the-art catalysts that operate in alkaline solutions, including the benchmark nickel iron oxide. This new catalyst is easily prepared from readily available and industrially relevant nickel foam, and it is stable for many hours. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.9b00053
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http://dx.doi.org/10.1021/acscentsci.9b00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439451PMC
March 2019
12 Reads

Tunable Coacervation of Well-Defined Homologous Polyanions and Polycations by Local Polarity.

ACS Cent Sci 2019 Mar 6;5(3):549-557. Epub 2019 Feb 6.

Department of Chemistry, Stanford University, Stanford, California 94305, United States.

The ionic complexation of polyelectrolytes is an important mechanism underlying many important biological processes and technical applications. The main driving force for complexation is electrostatic, which is known to be affected by the local polarity near charge centers, but the impact of which on the complexation of polyelectrolytes remains poorly explored. We developed a homologous series of well-defined polyelectrolytes with identical backbone structures, controlled molecular weights, and tunable local polarity to modulate the solvation environment near charged groups. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439447PMC

Cathepsin G Activity as a New Marker for Detecting Airway Inflammation by Microscopy and Flow Cytometry.

ACS Cent Sci 2019 Mar 19;5(3):539-548. Epub 2019 Feb 19.

Molecular Medicine Partnership Unit (MMPU), European Molecular Biology Laboratory (EMBL) and University of Heidelberg, 69117 Heidelberg, Germany.

Muco-obstructive lung diseases feature extensive bronchiectasis due to the uncontrolled release of neutrophil serine proteases into the airways. To assess if cathepsin G (CG) is a novel key player in chronic lung inflammation, we developed membrane-bound (mSAM) and soluble (sSAM) FRET reporters. The probes quantitatively revealed elevated CG activity in samples from 46 patients. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439450PMC
March 2019
2 Reads

Molecular Basis of Broad Spectrum -Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.

ACS Cent Sci 2019 Mar 6;5(3):524-538. Epub 2019 Feb 6.

Institute of Human Virology, Department of Microbiology & Immunology, and Program in Molecular Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, United States.

Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions. secretes a unique endo-β--acetylglucosaminidase, EndoS2, which deglycosylates the conserved -linked glycan at Asn297 on IgG Fc to eliminate its effector functions and evade the immune system. EndoS2 and specific point mutants have been used to chemoenzymatically synthesize antibodies with customizable glycosylation for gain of functions. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439443PMC

One- and Two-Dimensional High-Resolution NMR from Flat Surfaces.

ACS Cent Sci 2019 Mar 11;5(3):515-523. Epub 2019 Feb 11.

Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.

Determining atomic-level characteristics of molecules on two-dimensional surfaces is one of the fundamental challenges in chemistry. High-resolution nuclear magnetic resonance (NMR) could deliver rich structural information, but its application to two-dimensional materials has been prevented by intrinsically low sensitivity. Here we obtain high-resolution one- and two-dimensional P NMR spectra from as little as 160 picomoles of oligonucleotide functionalities deposited onto silicate glass and sapphire wafers. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439530PMC

Stabilization of Ruthenium(II) Polypyridyl Chromophores on Mesoporous TiO Electrodes: Surface Reductive Electropolymerization and Silane Chemistry.

ACS Cent Sci 2019 Mar 15;5(3):506-514. Epub 2019 Feb 15.

Department of Chemistry, University of North Carolina at Chapel Hill, CB#3290, Chapel Hill, North Carolina 27599-3290, United States.

Stabilization is a critical issue in the long term operation of dye-sensitized photoelectrosynthesis cells (DSPECs) for water splitting or CO reduction. The cells require a stable binding of the robust molecular chromophores, catalysts, and chromophore/catalyst assemblies on metal oxide semiconductor electrodes under the corresponding (photoelectro)chemical conditions. Here, an efficient stabilization strategy is presented based on functionalization of FTOTiO (mesoporous, nanostructured TiO deposited on fluorine-doped tin oxide (FTO) glass) electrodes with a vinylsilane followed by surface reductive electropolymerization of a vinyl-derivatized Ru(II) polypyridyl chromophore. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439529PMC
March 2019
4 Reads

Large-Scale Production of Te and Sb for Radiopharmaceutical Applications.

ACS Cent Sci 2019 Mar 25;5(3):494-505. Epub 2019 Feb 25.

Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States.

Radionuclides find widespread use in medical technologies for treating and diagnosing disease. Among successful and emerging radiotherapeutics, Sb has unique potential in targeted therapeutic applications for low-energy electron-emitting isotopes. Unfortunately, developing Sb-based drugs has been slow in comparison to other radionuclides, primarily due to limited accessibility. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00869
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http://dx.doi.org/10.1021/acscentsci.8b00869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439462PMC
March 2019
6 Reads

Using Microfluidics and Imaging SAMDI-MS To Characterize Reaction Kinetics.

ACS Cent Sci 2019 Mar 12;5(3):486-493. Epub 2019 Feb 12.

Department of Chemistry, Department of Chemical & Biological Engineering, and Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, United States.

Microfluidic platforms have enabled the simplification of biochemical assays with a significant reduction in the use of reagents, yet the current methods available for analyzing reaction products can limit applications of these approaches. This paper demonstrates a simple microfluidic device that incorporates a functionalized self-assembled monolayer to measure the rate constant for a chemical reaction. The device mixes the reactants and allows them to selectively immobilize to the monolayer at the base of a microfluidic channel in a time-dependent manner as they flow down the channel. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00867DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439460PMC

Promoting Angiogenesis in Oxidative Diabetic Wound Microenvironment Using a Nanozyme-Reinforced Self-Protecting Hydrogel.

ACS Cent Sci 2019 Mar 13;5(3):477-485. Epub 2019 Feb 13.

Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.

Impaired diabetic wound healing represents a devastating and rapidly growing clinical problem associated with high morbidity, mortality, and recurrence rates. Engineering therapeutic angiogenesis in the wounded tissue is critical for successful wound healing. However, stimulating functional angiogenesis of the diabetic wound remains a great challenge, due to the oxidative damage and denaturation of bio-macromolecule-based angiogenic agents in the oxidative diabetic wound microenvironment. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439452PMC

Self-Assembled Monolayer Enables Slurry-Coating of Li Anode.

ACS Cent Sci 2019 Mar 12;5(3):468-476. Epub 2019 Feb 12.

i-Lab, CAS Center for Excellence in Nanoscience, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China.

Li metal has long been considered as the ultimate anodic material for high-energy-density batteries. Protection of Li metal in electrochemical cycling and in the manufacturing environment is critical for practical applications. Here, we present the passivation of the Li metal-carbon nanotube (CNT) composite with molecular self-assembly of a long-chain aliphatic phosphonic acid. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439463PMC

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration.

ACS Cent Sci 2019 Mar 25;5(3):458-467. Epub 2019 Jan 25.

Department of Biomedical Science, College of Life Sciences, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea.

Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00812
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http://dx.doi.org/10.1021/acscentsci.8b00812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439446PMC
March 2019
6 Reads

Acoustic Droplet Ejection Enabled Automated Reaction Scouting.

ACS Cent Sci 2019 Mar 27;5(3):451-457. Epub 2019 Feb 27.

Department of Drug Design, University of Groningen, Deusinglaan 1, 7313 AV Groningen, The Netherlands.

Miniaturization and acceleration of synthetic chemistry are critically important for rapid property optimization in pharmaceutical, agrochemical, and materials research and development. However, in most laboratories organic synthesis is still performed on a slow, sequential, and material-consuming scale and not validated for multiple substrate combinations. Herein, we introduce fast and touchless acoustic droplet ejection (ADE) technology into small-molecule chemistry to transfer building blocks by nL droplets and to scout a newly designed isoquinoline synthesis. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439453PMC
March 2019
1 Read

Dynamic and Cell-Infiltratable Hydrogels as Injectable Carrier of Therapeutic Cells and Drugs for Treating Challenging Bone Defects.

ACS Cent Sci 2019 Mar 13;5(3):440-450. Epub 2019 Feb 13.

Department of Biomedical Engineering, The Chinese University of Hong Kong, William M.W. Mong Building, Shatin, Hong Kong SAR, China.

Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for biomedical applications. However, most conventional hydrogels cannot be injected after gelation and do not support the infiltration of cells because of the static nature of their network structure. Here, we develop unique cell-infiltratable and injectable (Ci-I) gelatin hydrogels, which are physically cross-linked by weak and highly dynamic host-guest complexations and are further reinforced by limited chemical cross-linking for enhanced stability, and then demonstrate the outstanding properties of these Ci-I gelatin hydrogels. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439455PMC
March 2019
2 Reads

How Do Surfactants Control the Agglomeration of Clathrate Hydrates?

ACS Cent Sci 2019 Mar 15;5(3):428-439. Epub 2019 Feb 15.

Department of Chemistry, The University of Utah, Salt Lake City, Utah 84112-0850, United States.

Clathrate hydrates can spontaneously form under typical conditions found in oil and gas pipelines. The agglomeration of clathrates into large solid masses plugs the pipelines, posing adverse safety, economic, and environmental threats. Surfactants are customarily used to prevent the aggregation of clathrate particles and their coalescence with water droplets. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439454PMC

3D Printed Absorber for Capturing Chemotherapy Drugs before They Spread through the Body.

ACS Cent Sci 2019 Mar 9;5(3):419-427. Epub 2019 Jan 9.

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, California 94720, United States.

Despite efforts to develop increasingly targeted and personalized cancer therapeutics, dosing of drugs in cancer chemotherapy is limited by systemic toxic side effects. We have designed, built, and deployed porous absorbers for capturing chemotherapy drugs from the bloodstream after these drugs have had their effect on a tumor, but before they are released into the body where they can cause hazardous side effects. The support structure of the absorbers was built using 3D printing technology. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439445PMC
March 2019
1 Read

Porous Aromatic Frameworks as a Platform for Multifunctional Applications.

ACS Cent Sci 2019 Mar 4;5(3):409-418. Epub 2019 Mar 4.

Key Laboratory of Polyoxometalate Science of Ministry of Education, Northeast Normal University, Changchun 130024, China.

Porous aromatic frameworks (PAFs), which are well-known for their large surface areas, associated porosity, diverse structures, and superb stability, have recently attracted broad interest. Taking advantage of widely available building blocks and various coupling strategies, customized porous architectures can be prepared exclusively through covalent bonding to satisfy necessary requirements. In addition, PAFs are composed of phenyl-ring-derived fragments that are easily modified with desired functional groups with the help of established synthetic chemistry techniques. Read More

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http://dx.doi.org/10.1021/acscentsci.9b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439448PMC
March 2019
1 Read

Carbon Nanomaterials for Energy and Biorelated Catalysis: Recent Advances and Looking Forward.

ACS Cent Sci 2019 Mar 8;5(3):389-408. Epub 2019 Feb 8.

Center of Advanced Science and Engineering for Carbon (Case4Carbon), Department of Macromolecular Science and Engineering, Case Western Reserve University (CWRU), 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.

Along with the wide investigation activities in developing carbon-based, metal-free catalysts to replace precious metal (e.g., Pt) catalysts for various green energy devices, carbon nanomaterials have also shown great potential for biorelated applications. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439526PMC
March 2019
1 Read

Polariton Chemistry: Action in the Dark.

ACS Cent Sci 2019 Mar 8;5(3):386-388. Epub 2019 Mar 8.

Department of Chemistry and Biochemistry. University of California San Diego, La Jolla, California 92093, United States.

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http://dx.doi.org/10.1021/acscentsci.9b00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439444PMC

The Paradox of Using Radionuclides To Treat Disease.

ACS Cent Sci 2019 Mar 25;5(3):383-385. Epub 2019 Feb 25.

Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States.

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http://dx.doi.org/10.1021/acscentsci.9b00139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439449PMC

Building Scaffolds To Rebuild Kidneys.

ACS Cent Sci 2019 Mar 27;5(3):380-382. Epub 2019 Feb 27.

Division of Nephrology, Kidney Research Institute, Institute for Stem Cell and Regenerative Medicine, Center for Dialysis Innovation, and Department of Bioengineering, Department of Medicine, University of Washington, Seattle, Washington 98195.

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http://dx.doi.org/10.1021/acscentsci.9b00099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439459PMC

Lakes and Rivers Are Getting Saltier.

Authors:
Deirdre Lockwood

ACS Cent Sci 2019 Mar 1;5(3):376-379. Epub 2019 Mar 1.

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http://dx.doi.org/10.1021/acscentsci.9b00191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439464PMC

A Conversation with Rodney Ruoff.

Authors:
Neil Savage

ACS Cent Sci 2019 Mar 12;5(3):374-375. Epub 2019 Mar 12.

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http://dx.doi.org/10.1021/acscentsci.9b00239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439461PMC

High-Performance Quasi-Solid-State MXene-Based Li-I Batteries.

ACS Cent Sci 2019 Feb 1;5(2):365-373. Epub 2019 Feb 1.

Centre for Clean Energy Technology, Faculty of Science, University of Technology Sydney, Sydney, New South Wales 2007, Australia.

Lithium-iodine (Li-I) batteries have attracted tremendous attention due to their high energy and power densities as well as the low cost of iodine. However, the severe shuttle effect of iodine species and the uncontrollable lithium dendrite growth have strongly hindered their practical applications. Here we successfully develop a quasi-solid-state Li-I battery enabled by a MXene-based iodine cathode and a composite polymer electrolyte (CPE) containing NaNO particles dispersing in a pentaerythritol-tetraacrylate-based (PETEA-based) gel polymer electrolyte. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00921
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http://dx.doi.org/10.1021/acscentsci.8b00921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396384PMC
February 2019
4 Reads

On Biomineralization: Enzymes Switch on Mesocrystal Assembly.

ACS Cent Sci 2019 Feb 1;5(2):357-364. Epub 2019 Feb 1.

Physical Chemistry, Department of Chemistry, University of Konstanz, Universitätsstr. 10, Konstanz 78464, Germany.

Cellular machineries guide the bottom-up pathways toward crystal superstructures based on the transport of inorganic precursors and their precise integration with organic frameworks. The biosynthesis of mesocrystalline spines entails concerted interactions between biomolecules and inorganic precursors; however, the bioinorganic interactions and interfaces that regulate material form and growth as well as the selective emergence of structural complexity in the form of nanostructured crystals are not clear. By investigating mineral nucleation under the regulation of recombinant proteins, we show that SpSM50, a matrix protein of the sea urchin spine, stabilizes mineral precursors via vesicle-confinement, a function conferred by a low-complexity, disordered region. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396387PMC
February 2019
4 Reads

Red Room-Temperature Phosphorescence of CDs@Zeolite Composites Triggered by Heteroatoms in Zeolite Frameworks.

ACS Cent Sci 2019 Feb 22;5(2):349-356. Epub 2019 Jan 22.

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China.

Carbon dots (CDs) with red-emitting room-temperature phosphorescence (RTP) are rarely reported because of the increasing nonradiative decay of the excited states and the decreasing energy gap between the excited states and ground states. Herein, we demonstrate a facile strategy for modulating the RTP properties of CDs in terms of donor-acceptor energy transfer (EnT) in the CDs-in-zeolite system. Upon tuning of the heteroatoms (Zn, Mn) doped in the aluminophosphate zeolite frameworks, CDs@zeolite composites with green and red phosphorescence have been prepared via in situ hydrothermal synthesis. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396386PMC
February 2019
1 Read

The Free Energy Landscape of Internucleosome Interactions and Its Relation to Chromatin Fiber Structure.

ACS Cent Sci 2019 Feb 24;5(2):341-348. Epub 2019 Jan 24.

Institute for Molecular Engineering, University of Chicago, Chicago, Illinois 60637, United States.

The supramolecular chromatin fiber is governed by molecular scale energetics and interactions. Such energetics originate from the fiber's building block, the nucleosome core particle (NCP). In recent years, the chromatin fiber has been examined through perturbative methods in attempts to extract the energetics of nucleosome association in the fiber. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396382PMC
February 2019

An ATP-Regulated Ion Transport Nanosystem for Homeostatic Perturbation Therapy and Sensitizing Photodynamic Therapy by Autophagy Inhibition of Tumors.

ACS Cent Sci 2019 Feb 8;5(2):327-340. Epub 2019 Jan 8.

Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, P. R. China.

In this article, an adenosine-triphosphate-regulated (ATP-regulated) ion transport nanosystem [SQU@PCN, porphyrinic porous coordination network (PCN) incorporated with squaramide (SQU)] was designed and synthesized for homeostatic perturbation therapy (HPT) and sensitizing photodynamic therapy (PDT) of tumors. It was found that this nanotransporter SQU@PCN easily accumulated in tumor sites while avoiding metabolic clearance and side effects. In response to a high expression of ATP in the tumor, SQU@PCN was decomposed because of the strong coordination of ATP with metal ligand of PCN. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00822
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http://dx.doi.org/10.1021/acscentsci.8b00822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396388PMC
February 2019
3 Reads

Ultranarrow-Band Wavelength-Selective Thermal Emission with Aperiodic Multilayered Metamaterials Designed by Bayesian Optimization.

ACS Cent Sci 2019 Feb 22;5(2):319-326. Epub 2019 Jan 22.

National Institute for Materials Science, 1-2-1 Sengen, Tsukuba 305-0047, Japan.

We computationally designed an ultranarrow-band wavelength-selective thermal radiator via a materials informatics method alternating between Bayesian optimization and thermal electromagnetic field calculation. For a given target infrared wavelength, the optimal structure was efficiently identified from over 8 billion candidates of multilayers consisting of multiple components (Si, Ge, and SiO). The resulting optimized structure is an aperiodic multilayered metamaterial exhibiting high and sharp emissivity with a Q-factor of 273. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00802DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396383PMC
February 2019

Nanoscale Ion Emitters in Native Mass Spectrometry for Measuring Ligand-Protein Binding Affinities.

ACS Cent Sci 2019 Feb 14;5(2):308-318. Epub 2019 Jan 14.

School of Chemistry, University of New South Wales, Dalton Building, Sydney, New South Wales 2052, Australia.

Electrospray ionization (ESI) mass spectrometry (MS) is a crucial method for rapidly determining the interactions between small molecules and proteins with ultrahigh sensitivity. However, nonvolatile molecules and salts that are often necessary to stabilize the native structures of protein-ligand complexes can readily adduct to protein ions, broaden spectral peaks, and lower signal-to-noise ratios in native MS. ESI emitters with narrow tip diameters (∼250 nm) were used to significantly reduce the extent of adduction of salt and nonvolatile molecules to protein complexes to more accurately measure ligand-protein binding constants than by use of conventional larger-bore emitters under these conditions. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396573PMC
February 2019

Time-Gated Ratiometric Detection with the Same Working Wavelength To Minimize the Interferences from Photon Attenuation for Accurate Detection.

ACS Cent Sci 2019 Feb 14;5(2):299-307. Epub 2019 Jan 14.

Institutes of Biomedical Sciences & Department of Chemistry & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, P. R. China.

Luminescence imaging, exhibiting noninvasive, sensitive, rapid, and versatile properties, plays an important role in biomedical applications. It is usually unsuitable for direct biodetection, because the detected luminescence intensity can be influenced by various factors such as the luminescent substance concentration, the depth of the luminescent substance in the organism, etc. Ratiometric imaging may eliminate the interference due to the luminescent substance concentration on the working signal. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396381PMC
February 2019
1 Read

Drug-Membrane Permeability across Chemical Space.

ACS Cent Sci 2019 Feb 8;5(2):290-298. Epub 2019 Jan 8.

Max Planck Institute for Polymer Research, 55128 Mainz, Germany.

Unraveling the relation between the chemical structure of small druglike compounds and their rate of passive permeation across lipid membranes is of fundamental importance for pharmaceutical applications. The elucidation of a comprehensive structure-permeability relationship expressed in terms of a few molecular descriptors is unfortunately hampered by the overwhelming number of possible compounds. In this work, we reduce a priori the size and diversity of chemical space to solve an analogous-but smoothed out-structure-property relationship problem. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00718
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http://dx.doi.org/10.1021/acscentsci.8b00718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396385PMC
February 2019
5 Reads

Powerful Anticolon Tumor Effect of Targeted Gene Immunotherapy Using Folate-Modified Nanoparticle Delivery of CCL19 To Activate the Immune System.

ACS Cent Sci 2019 Feb 28;5(2):277-289. Epub 2019 Jan 28.

Department of Neurosurgery and Institute of Neurosurgery, State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, PR China.

Targeted gene delivery systems have recently shown potential clinical benefits in cancer treatment. Recently, the immunologic therapies application in cancer therapy also showed a continuously increase. CCL19 has shown its great potential as a candidate immunomodulator for colon cancer therapy by increasing the possibility of interaction among dendritic cells, T and B cells in secondary lymphatic tissue, thus regulating the primary (or secondary) adaptive immune responses. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396391PMC
February 2019
4 Reads

A Biocatalytic Platform for Synthesis of Chiral Trifluoromethylated Organoborons.

ACS Cent Sci 2019 Feb 1;5(2):270-276. Epub 2019 Feb 1.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.

There are few biocatalytic transformations that produce fluorine-containing molecules prevalent in modern pharmaceuticals. To expand the scope of biocatalysis for organofluorine synthesis, we have developed an enzymatic platform for highly enantioselective carbene B-H bond insertion to yield versatile trifluoromethylated (α-CF) organoborons, an important class of organofluorine molecules that contain stereogenic centers bearing both CF and boron groups. In contrast to current "carbene transferase" enzymes that use a limited set of simple diazo compounds as carbene precursors, this system based on cytochrome ( cyt ) can accept a broad range of trifluorodiazo alkanes and deliver versatile chiral α-CF organoborons with total turnovers up to 2870 and enantiomeric ratios up to 98. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00679
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http://dx.doi.org/10.1021/acscentsci.8b00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396380PMC
February 2019
2 Reads

Computational Evolution of Threonine-Rich β-Hairpin Peptides Mimicking Specificity and Affinity of Antibodies.

ACS Cent Sci 2019 Feb 28;5(2):259-269. Epub 2019 Jan 28.

Center for Evolutionary Chemical Biology, Department of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark.

The development of recognition molecules with antibody-like properties is of great value to the biotechnological and bioanalytical communities. The recognition molecules presented here are peptides with a strong tendency to form β-hairpin structures, stabilized by alternate threonines, which are located at one face of the peptide. Amino acids at the other face of the peptide are available for interaction with the target molecule. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396188PMC
February 2019
3 Reads

Injectable Slippery Lubricant-Coated Spiky Microparticles with Persistent and Exceptional Biofouling-Resistance.

ACS Cent Sci 2019 Feb 14;5(2):250-258. Epub 2019 Jan 14.

The First Affiliated Hospital of Sun Yat-Sen University; State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510006, China.

Injectable micron-sized particles have historically achieved promising applications, but they continued to suffer from long-term biofouling caused by the adhesions of biomolecules, cells, and bacteria. Recently, a slippery lubricant infusion porous substrate (SLIPS) exhibited robust antiadhesiveness against many liquids; however, they were constructed using a 2D substrate, and they were not suitable for applications, such as injectable biomaterials. Inspired by SLIPS, here, we report the first case of injectable solid microparticles coated with a lubricating liquid surface to continuously resist biofouling. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396194PMC
February 2019
1 Read

Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.

ACS Cent Sci 2019 Feb 6;5(2):237-249. Epub 2019 Feb 6.

Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, United States.

Up to ∼20% of HIV-infected individuals eventually develop broadly neutralizing antibodies (bnAbs), and many of these antibodies (∼40%) target a region of dense high-mannose glycosylation on gp120 of the HIV envelope protein, known as the "high-mannose patch" (HMP). Thus, there have been numerous attempts to develop glycoconjugate vaccine immunogens that structurally mimic the HMP and might elicit bnAbs targeting this conserved neutralization epitope. Herein, we report on the immunogenicity of glycopeptides, designed by selection, that bind tightly to anti-HMP antibody 2G12. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396197PMC
February 2019
1 Read

Therapeutic Protein PEPylation: The Helix of Nonfouling Synthetic Polypeptides Minimizes Antidrug Antibody Generation.

ACS Cent Sci 2019 Feb 8;5(2):229-236. Epub 2019 Jan 8.

Beijing National Laboratory for Molecular Sciences, Center for Soft Matter Science and Engineering, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People's Republic of China.

Polymer conjugation is a clinically proven approach to generate long acting protein drugs with decreased immune responses. Although poly(ethylene glycol) (PEG) is one of the most commonly used conjugation partners due to its unstructured conformation, its therapeutic application is limited by its poor biodegradability, propensity to induce an anti-PEG immune response, and the resultant accelerated blood clearance (ABC) effect. Moreover, the prevailing preference of unstructured polymers for protein conjugation still lacks strong animal data support with appropriate control reagents. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396190PMC
February 2019
4 Reads

Colocalization of mA and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine -Methylation.

ACS Cent Sci 2019 Feb 4;5(2):218-228. Epub 2019 Feb 4.

Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, United States.

This Outlook calls attention to two seemingly disparate and emerging fields regarding viral genomics that may be correlated in a way previously overlooked. First, we describe identification of conserved potential G-quadruplex-forming sequences (PQSs) in viral genomes relevant to human health. Studies have demonstrated that PQSs are highly conserved and can fold to G-quadruplexes (G4s) to regulate viral processes. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00963
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http://dx.doi.org/10.1021/acscentsci.8b00963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396389PMC
February 2019
4 Reads

Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules.

ACS Cent Sci 2019 Feb 14;5(2):209-217. Epub 2019 Feb 14.

Department of Chemistry, Pohang University of Science and Technology (POSTECH), 77 Cheongam-Ro, Nam-Gu, Pohang 37673, Republic of Korea.

Alzheimer's disease (AD) is the most common form of dementia. The pathogenesis of the disease is associated with aggregated amyloid-β, hyperphosphorylated tau, a high level of metal ions, abnormal enzyme activities, and reactive astrocytes. This outlook gives an overview of fluorescent small molecules targeting AD biomarkers for ex vivo and in vivo imaging. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396189PMC
February 2019
2 Reads

A "Broad Spectrum" Carbene Transferase for Synthesis of Chiral α-Trifluoromethylated Organoborons.

ACS Cent Sci 2019 Feb 4;5(2):206-208. Epub 2019 Feb 4.

Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

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http://dx.doi.org/10.1021/acscentsci.9b00015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396192PMC
February 2019

Turning Organic Waste into Hydrogen.

Authors:
XiaoZhi Lim

ACS Cent Sci 2019 Feb 20;5(2):203-205. Epub 2019 Feb 20.

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http://dx.doi.org/10.1021/acscentsci.9b00132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396193PMC
February 2019
1 Read

A Conversation with Carson Bruns.

Authors:
Carmen Drahl

ACS Cent Sci 2019 Feb 6;5(2):201-202. Epub 2019 Feb 6.

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http://dx.doi.org/10.1021/acscentsci.9b00098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396191PMC
February 2019

Two Tryptophans Are Better Than One in Accelerating Electron Flow through a Protein.

ACS Cent Sci 2019 Jan 7;5(1):192-200. Epub 2019 Jan 7.

Beckman Institute, California Institute of Technology, Pasadena, California 91125, United States.

We have constructed and structurally characterized a azurin mutant , where two adjacent tryptophan residues (W124 and W122, indole separation 3.6-4.1 Å) are inserted between the Cu center and a Re photosensitizer coordinated to the imidazole of H126 (Re(H126)(CO)(4,7-dimethyl-1,10-phenanthroline)). Read More

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http://dx.doi.org/10.1021/acscentsci.8b00882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346393PMC
January 2019
3 Reads

The Importance of Salt-Enhanced Electrostatic Repulsion in Colloidal Crystal Engineering with DNA.

ACS Cent Sci 2019 Jan 8;5(1):186-191. Epub 2019 Jan 8.

Departments of Chemistry and Materials Science and Engineering, International Institute for Nanotechnology, and Physics and Astronomy, Northwestern University, Evanston, Illinois 60208, United States.

Realizing functional colloidal single crystals requires precise control over nanoparticles in three dimensions across multiple size regimes. In this regard, colloidal crystallization with programmable atom equivalents (PAEs) composed of DNA-modified nanoparticles allows one to program in a sequence-specific manner crystal symmetry, lattice parameter, and, in certain cases, crystal habit. Here, we explore how salt and the electrostatic properties of DNA regulate the attachment kinetics between PAEs. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346395PMC
January 2019

General Immobilization of Ultrafine Alloyed Nanoparticles within Metal-Organic Frameworks with High Loadings for Advanced Synergetic Catalysis.

ACS Cent Sci 2019 Jan 7;5(1):176-185. Epub 2019 Jan 7.

State Key Laboratory of Pulp and Paper Engineering, School of Chemistry and Chemical Engineering and Analytical and Testing Centre, South China University of Technology, Guangzhou 510640, China.

The development of a general synthesis approach for creating fine alloyed nanoparticles (NPs) in the pores of metal-organic frameworks (MOFs) shows great promise for advanced synergetic catalysis but has not been realized so far. Herein, for the first time we proposed a facile and general strategy to immobilize ultrafine alloyed NPs within the pores of an MOF by the galvanic replacement of transition-metal NPs (e.g. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00805
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http://dx.doi.org/10.1021/acscentsci.8b00805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346383PMC
January 2019
9 Reads

Quantum Chemistry on Quantum Computers: A Method for Preparation of Multiconfigurational Wave Functions on Quantum Computers without Performing Post-Hartree-Fock Calculations.

ACS Cent Sci 2019 Jan 31;5(1):167-175. Epub 2018 Dec 31.

Department of Chemistry and Molecular Materials Science, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.

The full configuration interaction (full-CI) method is capable of providing the numerically best wave functions and energies of atoms and molecules within basis sets being used, although it is intractable for classical computers. Quantum computers can perform full-CI calculations in polynomial time against the system size by adopting a quantum phase estimation algorithm (QPEA). In the QPEA, the preparation of initial guess wave functions having sufficiently large overlap with the exact wave function is recommended. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346626PMC
January 2019

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury.

ACS Cent Sci 2019 Jan 4;5(1):153-166. Epub 2019 Jan 4.

Department of Medical Genetics and Molecular Biochemistry, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania 19140, United States.

Mitochondrial Ca (Ca) uptake mediated by the mitochondrial calcium uniporter (MCU) plays a critical role in signal transduction, bioenergetics, and cell death, and its dysregulation is linked to several human diseases. In this study, we report a new ruthenium complex Ru265 that is cell-permeable, minimally toxic, and highly potent with respect to MCU inhibition. Cells treated with Ru265 show inhibited MCU activity without any effect on cytosolic Ca dynamics and mitochondrial membrane potential (ΔΨ). Read More

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http://dx.doi.org/10.1021/acscentsci.8b00773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346394PMC
January 2019
1 Read

Bioorthogonal Engineering of Bacterial Effectors for Spatial-Temporal Modulation of Cell Signaling.

ACS Cent Sci 2019 Jan 27;5(1):145-152. Epub 2018 Dec 27.

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

The complicated and entangled cell signaling network is dynamically regulated by a wide array of enzymes such as kinases. It remains desirable but challenging to specifically modulate individual, endogenous kinases within a cell, particularly in a spatial-temporally controlled fashion. Current strategies toward regulating the intracellular functions of a kinase of interest either lack specificity or require genetic engineering that may perturb its physiological activity. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00751
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http://dx.doi.org/10.1021/acscentsci.8b00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346392PMC
January 2019
6 Reads

High-Performance Concurrent Chemo-Immuno-Radiotherapy for the Treatment of Hematologic Cancer through Selective High-Affinity Ligand Antibody Mimic-Functionalized Doxorubicin-Encapsulated Nanoparticles.

ACS Cent Sci 2019 Jan 26;5(1):122-144. Epub 2018 Dec 26.

Laboratory of Nano- and Translational Medicine, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, and Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Non-Hodgkin lymphoma is one of the most common types of cancer. Relapsed and refractory diseases are still common and remain significant challenges as the majority of these patients eventually succumb to the disease. Herein, we report a translatable concurrent chemo-immuno-radiotherapy (CIRT) strategy that utilizes fully synthetic antibody mimic Selective High-Affinity Ligand (SHAL)-functionalized doxorubicin-encapsulated nanoparticles (Dox NPs) for the treatment of human leukocyte antigen-D related (HLA-DR) antigen-overexpressed tumors. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346391PMC
January 2019
2 Reads

High-Performance N-to-NH Conversion Electrocatalyzed by MoC Nanorod.

ACS Cent Sci 2019 Jan 19;5(1):116-121. Epub 2018 Dec 19.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054 Sichuan, China.

The synthesis of NH is mainly dominated by the traditional energy-consuming Haber-Bosch process with a mass of CO emission. Electrochemical conversion of N to NH emerges as a carbon-free process for the sustainable artificial N reduction reaction (NRR), but requires an efficient and stable electrocatalyst. Here, we report that the MoC nanorod serves as an excellent NRR electrocatalyst for artificial N fixation to NH with strong durability and acceptable selectivity under ambient conditions. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00734
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http://dx.doi.org/10.1021/acscentsci.8b00734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346386PMC
January 2019
2 Reads