437 results match your criteria Acs Biomaterials Science & Engineering[Journal]


Construction of a Quadrangular Tetramer and a Cage-Like Hexamer from Three-Helix Bundle-Linked Fusion Proteins.

ACS Synth Biol 2019 Apr 16. Epub 2019 Apr 16.

Division of Materials Science, Graduate School of Science and Technology , Nara Institute of Science and Technology , 8916-5 Takayama , Ikoma , Nara 630-0192 , Japan.

Self-assembled protein nanostructures have gained interest, owing to their potential applications in biomaterials; however, successful design and construction of protein nanostructures are limited. Herein, we constructed fusion protein 1 by linking the C-terminus of a dimerization domain and the N-terminus of another dimerization domain with a three-helix bundle protein, where it self-assembled mainly into tetramers. By replacing the C-terminal dimerization domain of 1 with a trimerization domain (fusion protein 2), hexamers were mainly obtained. Read More

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http://dx.doi.org/10.1021/acssynbio.9b00019DOI Listing

Critical Areas of Proliferation of Single Cells on Micropatterned Surfaces and Corresponding Cell Type Dependence.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science , Fudan University , Shanghai 200438 , People's Republic of China.

Material cues to influence cell proliferation are a fundamental issue in the fields of biomaterials, cell biology, tissue engineering, and regenerative medicine. This paper aims to investigate the proliferation of single mammal cells on micropatterned material surfaces. To this end, we prepared cell-adhesive circular microislands with 20 areas on the nonfouling background and systematically examined adhesion and proliferation behaviors of different kinds of single cells (primary stem and nonstem cells, cancer and normal cell lines) on micropatterns. Read More

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http://dx.doi.org/10.1021/acsami.9b03780DOI Listing

Sustained Release of Exendin 4 Using Injectable and Ionic-Nano-Complex Forming Polymer Hydrogel System for Long-Term Treatment of Type 2 Diabetes Mellitus.

ACS Appl Mater Interfaces 2019 Apr 18. Epub 2019 Apr 18.

Center for Biomaterials , Korea Institute of Science & Technology , Seoul 130-650 , Republic of Korea.

Daily treatment of diabetes to stabilize blood glucose level poses a challenge for patients with diabetes mellitus. Diabetes is a long-term metabolic disorder, and the treatment lasts for the rest of the patient's life after diagnosis. We presented a new injectable hydrogel depot system using exendin 4 (Ex-4) interactive and complex forming polymeric ionic-nano-particles for long-term antidiabetes treatment. Read More

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http://dx.doi.org/10.1021/acsami.8b19669DOI Listing

A Bioinspired Scaffold with Anti-Inflammatory Magnesium Hydroxide and Decellularized Extracellular Matrix for Renal Tissue Regeneration.

ACS Cent Sci 2019 Mar 25;5(3):458-467. Epub 2019 Jan 25.

Department of Biomedical Science, College of Life Sciences, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea.

Kidney diseases are a worldwide public health issue. Renal tissue regeneration using functional scaffolds with biomaterials has attracted a great deal of attention due to limited donor organ availability. Here, we developed a bioinspired scaffold that can efficiently induce renal tissue regeneration. Read More

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http://pubs.acs.org/doi/10.1021/acscentsci.8b00812
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http://dx.doi.org/10.1021/acscentsci.8b00812DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439446PMC
March 2019
5 Reads

Dynamic and Cell-Infiltratable Hydrogels as Injectable Carrier of Therapeutic Cells and Drugs for Treating Challenging Bone Defects.

ACS Cent Sci 2019 Mar 13;5(3):440-450. Epub 2019 Feb 13.

Department of Biomedical Engineering, The Chinese University of Hong Kong, William M.W. Mong Building, Shatin, Hong Kong SAR, China.

Biopolymeric hydrogels have been widely used as carriers of therapeutic cells and drugs for biomedical applications. However, most conventional hydrogels cannot be injected after gelation and do not support the infiltration of cells because of the static nature of their network structure. Here, we develop unique cell-infiltratable and injectable (Ci-I) gelatin hydrogels, which are physically cross-linked by weak and highly dynamic host-guest complexations and are further reinforced by limited chemical cross-linking for enhanced stability, and then demonstrate the outstanding properties of these Ci-I gelatin hydrogels. Read More

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http://dx.doi.org/10.1021/acscentsci.8b00764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439455PMC
March 2019
2 Reads

Contrasting Chemistry of Block Copolymer Films Controls the Dynamics of Protein Self-Assembly at the Nanoscale.

ACS Nano 2019 Apr 9. Epub 2019 Apr 9.

Max Planck-EPFL Lab for Molecular Nanoscience and Technology and Institute of Physics, EPFL , CH-1015 Lausanne , Switzerland.

Biological systems are able to control the assembly and positioning of proteins with nanoscale precision, as exemplified by the intricate molecular structures within cell membranes, virus capsids, and collagen matrices. Controlling the assembly of biomolecules is critical for the use of biomaterials in artificial systems such as antibacterial coatings, engineered tissue samples, and implanted medical devices. Furthermore, understanding the dynamics of protein assembly on heterogeneous templates will ultimately enable the control of protein crystallization in general. Read More

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http://dx.doi.org/10.1021/acsnano.8b08013DOI Listing
April 2019
1 Read

An Expanded Synthetic Biology Toolkit for Gene Expression Control in Acetobacteraceae.

ACS Synth Biol 2019 Apr 22;8(4):708-723. Epub 2019 Mar 22.

School of Chemical and Biomedical Engineering , Nanyang Technological University , 637459 Singapore.

The availability of different host chassis will greatly expand the range of applications in synthetic biology. Members of the Acetobacteraceae family of Gram-negative bacteria form an attractive class of nonmodel microorganisms that can be exploited to produce industrial chemicals, food and beverage, and biomaterials. One such biomaterial is bacterial cellulose, which is a strong and ultrapure natural polymer used in tissue engineering scaffolds, wound dressings, electronics, food additives, and other products. Read More

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http://dx.doi.org/10.1021/acssynbio.8b00168DOI Listing
April 2019
2 Reads

Pectin Methacrylate (PEMA) and Gelatin-Based Hydrogels for Cell Delivery: Converting Waste Materials into Biomaterials.

ACS Appl Mater Interfaces 2019 Apr 22;11(13):12283-12297. Epub 2019 Mar 22.

Department of Health Technology, Center for Intestinal Absorption and Transport of Biopharmaceuticals , Technical University of Denmark , 2800 Kgs. Lyngby , Denmark.

The emergence of nontoxic, eco-friendly, and biocompatible polymers derived from natural sources has added a new and exciting dimension to the development of low-cost and scalable biomaterials for tissue engineering applications. Here, we have developed a mechanically strong and durable hydrogel composed of an eco-friendly biopolymer that exists within the cell walls of fruits and plants. Its trade name is pectin, and it bears many similarities with natural polysaccharides in the native extracellular matrix. Read More

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http://dx.doi.org/10.1021/acsami.9b00154DOI Listing
April 2019
5 Reads

Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles.

ACS Nano 2019 Mar 15;13(3):3555-3572. Epub 2019 Mar 15.

Department of Biomedical & Pharmaceutical Sciences, Chapman University School of Pharmacy (CUSP), Harry and Diane Rinker Health Science Campus , Chapman University , Irvine , California 92618 , United States.

Patients with polycystic kidney disease (PKD) are characterized with uncontrolled hypertension. Hypertension in PKD is a ciliopathy, an abnormal function and/or structure of primary cilia. Primary cilia are cellular organelles with chemo and mechanosensory roles. Read More

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http://dx.doi.org/10.1021/acsnano.9b00033DOI Listing
March 2019
4 Reads

Micropatterned Viral Membrane Clusters for Antiviral Drug Evaluation.

ACS Appl Mater Interfaces 2019 Apr 5;11(15):13984-13990. Epub 2019 Apr 5.

School of Materials Science and Engineering , Nanyang Technological University , 50 Nanyang Drive , Singapore 637553 , Singapore.

The function of biological nanoparticles, such as membrane-enveloped viral particles, is often enhanced when the particles form higher-order supramolecular assemblies. While there is intense interest in developing biomimetic platforms that recapitulate these collective properties, existing platforms are limited to mimicking individual virus particles. Here, we present a micropatterning strategy to print linker molecules selectively onto bioinert surfaces, thereby enabling controlled tethering of biomimetic viral particle clusters across defined geometric patterns. Read More

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http://pubs.acs.org/doi/10.1021/acsami.9b01724
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http://dx.doi.org/10.1021/acsami.9b01724DOI Listing
April 2019
2 Reads

Surface Engineered Biomimetic Inks Based on UV Cross-Linkable Wood Biopolymers for 3D Printing.

ACS Appl Mater Interfaces 2019 Apr 19;11(13):12389-12400. Epub 2019 Mar 19.

Laboratory of Wood and Paper Chemistry, Johan Gadolin Process Chemistry Centre , Åbo Akademi University , Porthansgatan 3 , 20500 Turku , Finland.

Owing to their superior mechanical strength and structure similarity to the extracellular matrix, nanocelluloses as a class of emerging biomaterials have attracted great attention in three-dimensional (3D) bioprinting to fabricate various tissue mimics. Yet, when printing complex geometries, the desired ink performance in terms of shape fidelity and object resolution demands a wide catalogue of tunability on the material property. This paper describes surface engineered biomimetic inks based on cellulose nanofibrils (CNFs) and cross-linkable hemicellulose derivatives for UV-aided extrusion printing, being inspired by the biomimetic aspect of intrinsic affinity of heteropolysaccharides to cellulose in providing the ultrastrong but flexible plant cell wall structure. Read More

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http://dx.doi.org/10.1021/acsami.9b03442DOI Listing
April 2019
4 Reads

Magnetic-Sensitive Nanoparticle Self-Assembled Superhydrophobic Biopolymer-Coated Slow-Release Fertilizer: Fabrication, Enhanced Performance, and Mechanism.

ACS Nano 2019 Mar 7;13(3):3320-3333. Epub 2019 Mar 7.

National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, National Engineering & Technology Research Center for Slow and Controlled-release Fertilizers, College of Resources and Environment , Shandong Agricultural University , Taian , Shandong 271018 , China.

Although commercialized slow-release fertilizers coated with petrochemical polymers have revolutionarily promoted agricultural production, more research should be devoted to developing superhydrophobic biopolymer coatings with superb slow-release ability from sustainable and ecofriendly biomaterials. To inform the development of the superhydrophobic biopolymer-coated slow-release fertilizers (SBSF), the slow-release mechanism of SBSF needs to be clarified. Here, the SBSF with superior slow-release performance, water tolerance, and good feasibility for large-scale production was self-assembly fabricated using a simple, solvent-free process. Read More

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http://dx.doi.org/10.1021/acsnano.8b09197DOI Listing

Versatile Strategy To Generate a Rhodamine Triplet State as Mitochondria-Targeting Visible-Light Photosensitizers for Efficient Photodynamic Therapy.

ACS Appl Mater Interfaces 2019 Mar 20;11(9):8797-8806. Epub 2019 Feb 20.

Department of Chemistry , Southern University of Science and Technology , 1088 Xueyuan Blvd. , Shenzhen 518055 , China.

Through the use of a rhodamine-appended chelate, bpy-Rho, a versatile strategy has been demonstrated to readily form mitochondria-targeting photosensitizers via the incorporation of a variety of luminescent transition-metal systems, M-Rho, such as Re(I), Ir(III), Pt(II), and Rh(III). The emission from the rhodamine singlet excited state and the transition-metal triplet excited state is partially quenched by the depopulation of them into the dark rhodamine triplet excited state. The generation of the triplet excited state of a rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen (O) for use as a photodynamic therapy (PDT) agent upon visible-light irradiation. Read More

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http://dx.doi.org/10.1021/acsami.8b20224DOI Listing

Spatial Distribution of Biomaterial Microenvironment pH and Its Modulatory Effect on Osteoclasts at the Early Stage of Bone Defect Regeneration.

ACS Appl Mater Interfaces 2019 Mar 19;11(9):9557-9572. Epub 2019 Feb 19.

Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology , Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences , Shenzhen 518055 , China.

It is generally accepted that biodegradable materials greatly influence the nearby microenvironment where cells reside; however, the range of interfacial properties has seldom been discussed due to technical bottlenecks. This study aims to depict biomaterial microenvironment boundaries by correlating interfacial H distribution with surrounding cell behaviors. Using a disuse-related osteoporotic mouse model, we confirmed that the abnormal activated osteoclasts could be suppressed under relatively alkaline conditions. Read More

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http://dx.doi.org/10.1021/acsami.8b20580DOI Listing
March 2019
3 Reads

Electrophoretic Deposition of Bioadaptive Drug Delivery Coatings on Magnesium Alloy for Bone Repair.

ACS Appl Mater Interfaces 2019 Feb 18;11(8):8625-8634. Epub 2019 Feb 18.

Institute of Biomaterials, Department of Materials Science and Engineering , University of Erlangen-Nuremberg , Cauerstraße 6 , 91058 Erlangen , Germany.

Biodegradable polymer coatings on magnesium alloys are attractive, as they can provide corrosion resistance as well as additional functions for biomedical applications, e.g., drug delivery. Read More

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http://dx.doi.org/10.1021/acsami.9b01227DOI Listing
February 2019
2 Reads
6.723 Impact Factor

Mussel-Inspired Electroactive and Antioxidative Scaffolds with Incorporation of Polydopamine-Reduced Graphene Oxide for Enhancing Skin Wound Healing.

ACS Appl Mater Interfaces 2019 Feb 14;11(8):7703-7714. Epub 2019 Feb 14.

Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering , Southwest Jiaotong University , Chengdu , Sichuan 610031 , China.

Wound repair and tissue regeneration are complex processes that involve many physiological signals. Thus, employing novel wound dressings with potent biological activity and physiological signal response ability to accelerate wound healing is a possible solution. Herein, inspired by mussel chemistry, we developed a polydopamine (PDA)-reduced graphene oxide (pGO)-incorporated chitosan (CS) and silk fibroin (SF) (pGO-CS/SF) scaffold with good mechanical, electroactive, and antioxidative properties as an efficient wound dressing. Read More

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http://dx.doi.org/10.1021/acsami.8b18931DOI Listing
February 2019
5 Reads

Hydrolytic Degradation and Erosion of Polyester Biomaterials.

ACS Macro Lett 2018 Aug 30;7(8):976-982. Epub 2018 Jul 30.

Department of Biomedical Engineering, Texas A&M University, College Station, Texas 77843, United States.

Strategies to refine the degradation behavior of polyester biomaterials, particularly to overcome the limitations of slow hydrolytic degradation, would broaden their utility. Herein, we examine the complexities of polyester degradation behavior, its assessment and strategies for refinement. The factors governing polyester degradation are strikingly complex. Read More

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http://dx.doi.org/10.1021/acsmacrolett.8b00424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350899PMC
August 2018
2 Reads

An Oxygen Self-sufficient Fluorinated Nanoplatform for Relieved Tumor Hypoxia and Enhanced Photodynamic Therapy of Cancers.

ACS Appl Mater Interfaces 2019 Feb 12;11(8):7731-7742. Epub 2019 Feb 12.

College of Materials Science and Engineering , Nanjing Tech University , No. 30 Puzhu Road(S) , Nanjing 211816 , P. R. China.

The efficacy of photodynamic therapy (PDT) in the solid tumor is hampered by many challenges, including its oxygen self-consuming nature, insufficient oxygen levels within the hypoxic tumor microenvironment, and limited penetration of photosensitizers within tumors. Herein, we develop the IR780@O-SFNs/iRGD as an oxygen self-sufficient and tumor-penetrating nanoplatform, which consists of IR780-loaded pH-sensitive fluorocarbon-functionalized nanoparticles (SFNs) and iRGD as a tumor targeting peptide that can penetrate deeper within the tumor. Because of the high oxygen affinity and outstanding permeability of the obtained nanoplatform, oxygen and IR780 which are encapsulated in the same core can play their roles to the utmost, resulting in remarkably accelerated singlet oxygen production, as demonstrated in vitro by the 3D multicellular spheroids and in vivo by tumor tissues. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b19840
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http://dx.doi.org/10.1021/acsami.8b19840DOI Listing
February 2019
8 Reads

Mechanical Strength, Biodegradation, and in Vitro and in Vivo Biocompatibility of Zn Biomaterials.

ACS Appl Mater Interfaces 2019 Feb 8;11(7):6809-6819. Epub 2019 Feb 8.

Nancy E and Peter C. Meinig School of Biomedical Engineering , Cornell University , New York 14853 , United States.

Zn-based biomaterials have emerged as promising new types of bioresorbable metallics applicable to orthopedic devices, cardiovascular stents, and other medical applications recently. Compared to other degradable metallic biomaterials (i.e. Read More

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http://dx.doi.org/10.1021/acsami.8b20634DOI Listing
February 2019
1 Read

Tough and Immunosuppressive Titanium-Infiltrated Exoskeleton Matrices for Long-Term Endoskeleton Repair.

ACS Appl Mater Interfaces 2019 Mar 7;11(10):9786-9793. Epub 2019 Feb 7.

Department of Nanomechanics, Korea Institute of Machinery and Materials (KIMM) , University of Science and Technology (UST) , 156 Gajeongbuk-ro , Yuseong-gu, Daejeon 34103 , Korea.

Although biodegradable membranes are essential for effective bone repair, severe loss of mechanical stability because of rapid biodegradation, soft tissue invasion, and excessive immune response remain intrinsically problematic. Inspired by the exoskeleton-reinforcing strategy found in nature, we have produced a Ti-infiltrated chitin nanofibrous membrane. The membrane employs vapor-phase infiltration of metals, which often occurs during metal oxide atomic layer deposition (ALD) on organic substrates. Read More

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http://dx.doi.org/10.1021/acsami.8b21569DOI Listing
March 2019
1 Read

Gold Nanoparticle Probe-Assisted Antigen-Counting Chip Using SEM.

ACS Appl Mater Interfaces 2019 Feb 6;11(7):6769-6776. Epub 2019 Feb 6.

State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory of Biomaterials and Devices, School of Biological Science and Medical Engineering , Southeast University , Nanjing 210009 , China.

Currently, it remains challenging to count protein-biomarker molecules present in a small droplet of biological samples. Herein, we propose a gold nanoparticle (GNP) probe-assisted sandwich-counting strategy that relies on a GNP probe, an antibody-functionalized chip to "count" antigen molecules using a scanning electron microscope. Both standard carcinoembryonic antigen (CEA) and two real CEA-related tumor samples (tumor tissues and serum) were assayed to demonstrate the proof-of-concept of the counting strategy. Read More

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http://dx.doi.org/10.1021/acsami.8b19055DOI Listing
February 2019

Deciphering the Rules for Amino Acid Co-Assembly Based on Interlayer Distances.

ACS Nano 2019 Feb 25;13(2):1703-1712. Epub 2019 Jan 25.

Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences , Tel Aviv University , Tel Aviv 69978 , Israel.

Metabolite materials are extremely useful to obtain functional bioinspired assemblies with unique physical properties for various applications in the fields of material science, engineering, and medicine by self-assembly of the simplest biological building blocks. Supramolecular co-assembly has recently emerged as a promising extended approach to further expand the conformational space of metabolite assemblies in terms of structural and functional complexity. Yet, the design of synergistically co-assembled amino acids to produce tailor-made functional architectures is still challenging. Read More

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http://pubs.acs.org/doi/10.1021/acsnano.8b07775
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http://dx.doi.org/10.1021/acsnano.8b07775DOI Listing
February 2019
12 Reads

Enhanced oral absorption of insulin using colon-specific nanoparticles co-modified with amphiphilic chitosan derivatives and cell-penetrating peptides.

Biomater Sci 2019 Mar;7(4):1493-1506

School of Pharmacy, Nanchang University, 461 Bayi Road, Donghu District, Nanchang, 330006, China.

In this study, amphipathic chitosan derivative (ACS) and cell-penetrating peptide (CPP) co-modified colon-specific nanoparticles (CS-CPP NPs) were prepared and evaluated to improve the oral bioavailability of protein and peptide drugs. ACS modification was harnessed to protect CPPs from degradation in the stomach and small intestine after oral administration and achieve colon-specific drug delivery. After CS-CPP NPs reached the colon, ACSs on the surface of the NPs were gradually degraded and CPPs were exposed to bring into play the penetration efficacy in the colon epithelium. Read More

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http://dx.doi.org/10.1039/c8bm01485jDOI Listing
March 2019
1 Read

Cu-Releasing Bioactive Glass Coatings and Their in Vitro Properties.

ACS Appl Mater Interfaces 2019 Feb 29;11(6):5812-5820. Epub 2019 Jan 29.

Institute of Biomaterials, Department of Materials Science and Engineering , University of Erlangen-Nuremberg , Cauerstr. 6 , 91058 Erlangen , Germany.

Bioactive glasses are well-known materials suitable for bone-related applications thanks to their biocompatibility and osteoconductivity. In order to improve their in vivo performance, the modification of the glass composition by adding ions with specific biological functions is required. As copper (Cu) possesses antibacterial properties, in this study, 5 wt % of CuO has been added to the 45S5 bioactive glass composition. Read More

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http://dx.doi.org/10.1021/acsami.8b19082DOI Listing
February 2019
1 Read

Fish Collagen Surgical Compress Repairing Characteristics on Wound Healing Process In Vivo.

Mar Drugs 2019 Jan 8;17(1). Epub 2019 Jan 8.

Department of Marine Bio-Pharmacology, College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.

The development of biomaterials with the potential to accelerate wound healing is a great challenge in biomedicine. In this study, four types of samples including pepsin soluble collagen sponge (PCS), acid soluble collagen sponge (ACS), bovine collagen electrospun I (BCE I) and bovine collagen electrospun II (BCE II) were used as wound dressing materials. We showed that the PCS, ACS, BCE I and BCE II treated rats increased the percentage of wound contraction, reduced the inflammatory infiltration, and accelerated the epithelization and healing. Read More

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http://dx.doi.org/10.3390/md17010033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357035PMC
January 2019
2 Reads

Enzymatically Cross-Linked Silk Fibroin-Based Hierarchical Scaffolds for Osteochondral Regeneration.

ACS Appl Mater Interfaces 2019 Jan 16;11(4):3781-3799. Epub 2019 Jan 16.

3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradables and Biomimetics of University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine , Avepark, Parque de Ciência e Tecnologia Zona Industrial da Gandra, 4805-017 Barco, Guimarães , Portugal.

Osteochondral (OC) regeneration faces several limitations in orthopedic surgery, owing to the complexity of the OC tissue that simultaneously entails the restoration of articular cartilage and subchondral bone diseases. In this study, novel biofunctional hierarchical scaffolds composed of a horseradish peroxidase (HRP)-cross-linked silk fibroin (SF) cartilage-like layer (HRP-SF layer) fully integrated into a HRP-SF/ZnSr-doped β-tricalcium phosphate (β-TCP) subchondral bone-like layer (HRP-SF/dTCP layer) were proposed as a promising strategy for OC tissue regeneration. For comparative purposes, a similar bilayered structure produced with no ion incorporation (HRP-SF/TCP layer) was used. Read More

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http://dx.doi.org/10.1021/acsami.8b21259DOI Listing
January 2019
1 Read

Triple-Bioinspired Burying/Crosslinking Interfacial Coassembly Strategy for Layer-by-Layer Construction of Robust Functional Bioceramic Self-Coatings for Osteointegration Applications.

ACS Appl Mater Interfaces 2019 Jan 17;11(4):4447-4469. Epub 2019 Jan 17.

Department of Materials Science and Engineering, College of Engineering , Peking University , Beijing 100871 , China.

Coating bioceramics of inherent bioactivity onto biometallic implants is a straightforward yet promising solution to address poor osteointegration of the latter. One step further, it would be a nontrivial accomplishment to develop a mild, cheap, and universal route to firmly stabilizing, in principle, any ceramics onto any implant substrate, while imparting expectedly versatile biofunctional performances. Herein, we describe a triple-bioinspired burying/cross-linking interfacial coassembly strategy for enabling such ceramic coatings, which ingeniously fuses bioinspiration from sea rocks (burying assisted particle immobilization), marine mussels (universal adhesion and versatile chemical reactivity), and reef-building oysters (cross-linking rendered cohesion). Read More

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http://dx.doi.org/10.1021/acsami.8b20429DOI Listing
January 2019
2 Reads

RGD Mutation of the Heparin Binding II Fragment of Fibronectin for Guiding Mesenchymal Stem Cell Behavior on Titanium Surfaces.

ACS Appl Mater Interfaces 2019 Jan 16;11(4):3666-3678. Epub 2019 Jan 16.

Institute for Bioengineering of Catalonia (IBEC) , Barcelona Institute of Science and Technology (BIST) , 08028 Barcelona , Spain.

Installing bioactivity on metallic biomaterials by mimicking the extracellular matrix (ECM) is crucial for stimulating specific cellular responses to ultimately promote tissue regeneration. Fibronectin is an ECM protein commonly used for biomaterial functionalization. The use of fibronectin recombinant fragments is an attractive alternate to the use of full-length fibronectin because of the relatively low cost and facility of purification. Read More

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http://dx.doi.org/10.1021/acsami.8b17138DOI Listing
January 2019

Photosensitizer-Loaded Multifunctional Chitosan Nanoparticles for Simultaneous in Situ Imaging, Highly Efficient Bacterial Biofilm Eradication, and Tumor Ablation.

ACS Appl Mater Interfaces 2019 Jan 31;11(2):2302-2316. Epub 2018 Dec 31.

School of Ophthalmology & Optometry, Eye Hospital , Wenzhou Medical University , Wenzhou 325027 , China.

In recent decades, bacterial and viral infections and chronic inflammatory response have emerged as important causes of cancer. Also, infections remain a significant cause of morbidity and mortality in cancer patients. In this work, carboxymethyl chitosan nanoparticles (CMC NPs) were synthesized in a facile and green way and further combined with ammonium methylbenzene blue (MB) as a cross-linking agent as well as a fluorescent molecule and a photosensitizer for self-imaging photodynamic therapy (PDT). Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b19522
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http://dx.doi.org/10.1021/acsami.8b19522DOI Listing
January 2019
3 Reads

Fully Packaged Portable Thin Film Biosensor for the Direct Detection of Highly Pathogenic Viruses from On-Site Samples.

ACS Nano 2019 Jan 31;13(1):812-820. Epub 2018 Dec 31.

Center for Biomaterials , Korea Institute of Science and Technology (KIST) , Seoul 02792 , Republic of Korea.

The thin film transistor (TFT) is a promising biosensor system with great sensitivity, label-free detection, and a quick response time. However, even though the TFT sensor has such advantageous characteristics, the disadvantages hamper the TFT sensor's application in the clinical field. The TFT is susceptible to light, noise, vibration, and limited usage, and this significantly limits its on-site potential as a practical biosensor. Read More

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http://dx.doi.org/10.1021/acsnano.8b08298DOI Listing
January 2019
1 Read

Effects of Molecular Weight and Concentration of Poly(Acrylic Acid) on Biomimetic Mineralization of Collagen.

ACS Biomater Sci Eng 2018 Aug 29;4(8):2758-2766. Epub 2018 Jun 29.

MDRCBB, Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota, 16-212 Moos Tower, 515 Delaware St. SE, Minneapolis, MN, USA.

Inspired by nature, poly(acrylic acid) (PAA) and other polyelectrolytes have been used as noncollagenous proteins (NCPs) surrogates for biomimetic intrafibrillar mineralization of collagen fibrils and thus, to model the ultrastructure of bone, to study the mechanism of bone mineralization and, more scarcely to fabricate scaffolds for hard tissue engineering. The objective of this study was to systematically investigate the effect of the molecular weight (MW) and the concentration of PAA on the rate and pattern of biomineralization of collagen matrices. Densified type I collagen films were mineralized in supersaturated PAA-stabilized amorphous calcium-phosphate (PAA-ACP) solutions containing increasing MW (2 kDa, 50 kDA, 450 kDa) and concentrations (10, 25, 50 mg/L) of PAA up to 7 days. Read More

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http://pubs.acs.org/doi/10.1021/acsbiomaterials.8b00512
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http://dx.doi.org/10.1021/acsbiomaterials.8b00512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298758PMC
August 2018
17 Reads

Nonfluorinated Superomniphobic Surfaces through Shape-Tunable Mushroom-like Polymeric Micropillar Arrays.

ACS Appl Mater Interfaces 2019 Feb 4;11(5):5484-5491. Epub 2019 Jan 4.

School of Electrical and Electronic Engineering , Yonsei University , Seoul 03722 , Republic of Korea.

Superomniphobic surfaces showing extremely liquid-repellent properties have received a great amount of attention as they can be used in various industrial and biomedical applications. However, so far, the fabrication processes of these materials mostly have involved the coating of perfluorocarbons onto micro- and nanohierarchical structures of these surfaces, which inevitably causes environmental pollution, leading to health concerns. Herein, we developed a facile method to obtain flexible superomniphobic surfaces without perfluorocarbon coatings that have shape-tunable mushroom-like micropillars (MPs). Read More

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http://dx.doi.org/10.1021/acsami.8b17181DOI Listing
February 2019
2 Reads

Composite bijel-templated hydrogels for cell delivery.

ACS Biomater Sci Eng 2018 Feb 18;4(2):587-594. Epub 2018 Jan 18.

Department of Chemical Engineering and Materials Science, University of California, Irvine, CA 92697, USA.

Numerous processing techniques aim to impart interconnected, porous structures within regenerative medicine materials to support cell delivery and direct tissue growth. Many of these techniques lack predictable control of scaffold architecture, and rapid prototyping methods are often limited by time-consuming, layer-by-layer fabrication of micro-features. Bicontinuous interfacially jammed emulsion gels (bijels) offer a robust, self-assembly-based platform for synthesizing a new class of morphologically unique cell delivery biomaterials. Read More

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http://pubs.acs.org/doi/10.1021/acsbiomaterials.7b00809
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http://dx.doi.org/10.1021/acsbiomaterials.7b00809DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294128PMC
February 2018
14 Reads

Chitosan/Calcium Silicate Cardiac Patch Stimulates Cardiomyocyte Activity and Myocardial Performance after Infarction by Synergistic Effect of Bioactive Ions and Aligned Nanostructure.

ACS Appl Mater Interfaces 2019 Jan 28;11(1):1449-1468. Epub 2018 Dec 28.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics , Chinese Academy of Sciences (CAS) , Shanghai 200050 , P. R. China.

Cardiac tissue engineering (CTE) remains a great challenge to construct a cell-inductive scaffold that has positive effects on cardiac cell behaviors and cardiac tissue repair. In this study, we for the first time demonstrated that Si ions evidently stimulated the expression of cardiac-specific genes and proliferation of neonatal rat cardiomyocytes (NRCMs) at concentration ranges of 0.13-10. Read More

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http://dx.doi.org/10.1021/acsami.8b17754DOI Listing
January 2019

Printing Birefringent Figures by Surface Tension-Directed Self-Assembly of a Cellulose Nanocrystal/Polymer Ink Components.

ACS Appl Mater Interfaces 2019 Jan 24;11(1):1538-1545. Epub 2018 Dec 24.

Laboratory of Renewable Nanomaterials, School of Forest Resources , University of Maine , Orono , Maine 04469 , United States.

Photonic printing on transparent substrates using emerging synthetic photonic crystals is in high demand, especially for antifraud applications. However, photonic printing is faced with grand challenges including lack of full invisibility of printed patterns before stimulation or after stimulus removal and absence of the long-lasting stability. Natural anisotropic crystal structures and artificially molecularly arranged polymers show an optically anisotropic property known as birefringence. Read More

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http://dx.doi.org/10.1021/acsami.8b14899DOI Listing
January 2019

Tacrolimus- and Nerve Growth Factor-Treated Allografts for Neural Tissue Regeneration.

ACS Chem Neurosci 2019 Mar 7;10(3):1411-1419. Epub 2019 Jan 7.

John A. Paulson School of Engineering and Applied Sciences , Harvard University , Cambridge , Massachusetts 02138 , United States.

Treatment of injured peripheral nerves, especially long-distance nerve defects, remains a significant challenge in regenerative medicine due to complex biological conditions and a lack of biomaterials for effective nerve reconstruction. Without proper treatment, nerve injury leads to motor and sensory dysfunction. Here, we have developed an efficacious nerve allograft treated with a dual drug containing acrolimus and nerve growth factor to bridge the nerve gap and achieve rapid neural tissue recovery without immunological rejection. Read More

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http://dx.doi.org/10.1021/acschemneuro.8b00452DOI Listing
March 2019
4.362 Impact Factor

Magnetic Cell-Scaffold Interface Constructed by Superparamagnetic IONP Enhanced Osteogenesis of Adipose-Derived Stem Cells.

ACS Appl Mater Interfaces 2018 Dec 12;10(51):44279-44289. Epub 2018 Dec 12.

Jiangsu Key Laboratory of Oral Diseases , Nanjing Medical University , Nanjing , Jiangsu 210029 , China.

One of the key factors in tissue engineering and regenerative medicine is to optimize the interaction between seed cells and scaffolds such that the cells can grow in naturally biomimetic conditions. Their similarity to macromolecules and many unique properties mean that functional nanoparticles have promising potential for the modification and improvement of traditional scaffolds to obtain excellent biocompatibility, tunable stiffness, physical sensing, and stimulus-response capabilities. In the present study, we report magnetic poly(lactic- co-glycolic acid)/polycaprolactone (PLGA/PCL) scaffolds that were fabricated using a combination of the electrospinning technique and layer-by-layer assembly of superparamagnetic iron oxide nanoparticles (IONPs). Read More

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http://dx.doi.org/10.1021/acsami.8b17427DOI Listing
December 2018
1 Read

Quantitative Single-Cell Analysis of Isolated Cancer Cells with a Microwell Array.

ACS Comb Sci 2019 Feb 13;21(2):98-104. Epub 2018 Dec 13.

Center for Biomaterials, Biomedical Research Institute , Korea Institute of Science and Technology (KIST) , 5 Hwarang-ro 14-gil , Seongbuk-gu, Seoul 02792 , Republic of Korea.

The heterogeneous nature of tumor-cell populations suggests that quantitative analysis at the single-cell level may provide better insights into cancer biology. Specifically, detection of multiple biomarkers from a single cell offers important initial information about cellular behavior. However, conventional approaches limit biomarker detection at the single-cell level. Read More

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http://dx.doi.org/10.1021/acscombsci.8b00151DOI Listing
February 2019
3 Reads

Detachable Polyzwitterion-Coated Ternary Nanoparticles Based on Peptide Dendritic Carbon Dots for Efficient Drug Delivery in Cancer Therapy.

ACS Appl Mater Interfaces 2018 Dec 5;10(50):43923-43935. Epub 2018 Dec 5.

National Engineering Research Center for Biomaterials , Sichuan University , 29 Wangjiang Road , Chengdu 610064 , P. R. China.

In this work, we presented ternary nanoparticles [poly(carboxybetaine methacrylate) (pCBMA)(peptide dendrimer-modified carbon dots (CD-D)/doxorubicin (DOX))] based on peptide dendritic carbon dots (CDs) to realize tumor-specific drug delivery and highly efficient cancer therapy. The versatile nanoparticles could achieve "stealth" delivery in blood due to the antifouling zwitterion coating. Meanwhile, charge changes of the zwitterions could be moderated during their transportation toward/inside tumor cells, where subtle environmental pH variations acted as potent stimuli to actualize desired functions. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b17041
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http://dx.doi.org/10.1021/acsami.8b17041DOI Listing
December 2018
6 Reads

An injectable continuous stratified structurally and functionally biomimetic construct for enhancing osteochondral regeneration.

Biomaterials 2019 Feb 13;192:149-158. Epub 2018 Nov 13.

Shanghai Jiao Tong University Affiliated Sixth People's Hospital, School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, PR China; School of Biomedical Engineering, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, 200030, PR China. Electronic address:

Osteochondral regeneration with the formation of hyaline cartilage and subchondral bone as well as the integration between the newly formed tissues with the host tissue still remains a great challenge. In this study, a construct containing an injectable continuous stratified scaffold and multiple cell systems was designed for enhancing osteochondral regeneration. Briefly, an injectable sodium alginate(SA)/bioglass (BG) composite hydrogel containing bone marrow stem cells (BMSCs) (SA/BG + BMSCs) was used for subchondral bone regeneration and an injectable thermosensitive SA/agarose (AG) composite hydrogel with co-culture of BMSCs and articular chondrocytes (ACs) (SA/AG + ACs/BMSCs) was applied for articular cartilage regeneration. Read More

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http://dx.doi.org/10.1016/j.biomaterials.2018.11.017DOI Listing
February 2019
16 Reads

Hydrogen-Bonded Tannic Acid-Based Anticancer Nanoparticle for Enhancement of Oral Chemotherapy.

ACS Appl Mater Interfaces 2018 Dec 29;10(49):42186-42197. Epub 2018 Nov 29.

School of Materials Science and Engineering, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, GD Research Center for Functional Biomaterials Engineering and Technology , Sun Yat-sen University , Guangzhou 510275 , China.

Oral chemotherapy has been emerging as a hopeful therapeutic regimen for the treatment of various cancers because of its high safety and convenience, lower costs, and high patient compliance. Currently, nanoparticulate drug delivery systems (NDDS) exhibit many unique advantages in mediating oral drug delivery; however, many anticancer drugs that were susceptible in hostile gastrointestinal (GI) environment showed poor permeability across intestinal epithelium, and most materials used as drug carriers are nonactive excipients and displayed no therapeutically relevant function, which leads to low oral bioavailability and therapeutic efficacy of anticancer drugs (e.g. Read More

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http://dx.doi.org/10.1021/acsami.8b18979DOI Listing
December 2018
3 Reads

Effect of Local Alkaline Microenvironment on the Behaviors of Bacteria and Osteogenic Cells.

ACS Appl Mater Interfaces 2018 Dec 27;10(49):42018-42029. Epub 2018 Nov 27.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics , Chinese Academy of Sciences , Shanghai 200050 , China.

The interactions between material surfaces and bacteria/cells have been widely investigated, based on which biomaterials with antibacterial and osteogenic abilities can be designed to conquer implant failures. The pH of environments is known to affect bacterial growth and bone formation/resorption, and it is possible that the antibacterial and osteogenic abilities of biomaterials can be simultaneously improved by regulating their surface alkalinity. Herein, we fabricated many kinds of films with various alkalinity levels on titanium surface to explore the effect of local alkaline microenvironments around material surfaces on the behaviors of bacteria and osteogenic cells. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b15724
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http://dx.doi.org/10.1021/acsami.8b15724DOI Listing
December 2018
14 Reads

Folic Acid-Conjugated Cellulose Nanocrystals Show High Folate-Receptor Binding Affinity and Uptake by KB and Breast Cancer Cells.

ACS Omega 2018 Oct 24;3(10):13952-13959. Epub 2018 Oct 24.

Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences (MC0298), 325 Stanger Street, Blacksburg, Virginia 24061, United States.

The study evaluates cellulose nanocrystals (CNCs) as nanocarriers for targeted, intracellular delivery of molecular agents. CNCs were labeled with fluorescein-5'-isothiocyanate as an imaging agent and conjugated to folic acid (FA) as a targeting ligand. The CNC conjugates were characterized by UV-vis spectroscopy, ζ-potential analysis, dynamic light scattering, and atomic force microscopy. Read More

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http://pubs.acs.org/doi/10.1021/acsomega.8b01619
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http://dx.doi.org/10.1021/acsomega.8b01619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217680PMC
October 2018
12 Reads

TC4/Ag Metal Matrix Nanocomposites Modified by Friction Stir Processing: Surface Characterization, Antibacterial Property, and Cytotoxicity in Vitro.

ACS Appl Mater Interfaces 2018 Dec 20;10(48):41155-41166. Epub 2018 Nov 20.

State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai 200240 , China.

Numerous antibacterial biomaterials have been developed, but a majority of them suffer from poor biocompatibility. With the purpose of reducing biomaterial-related infection and cytotoxicity, friction stir processing (FSP) was employed to embed silver nanoparticles (Ag NPs) in a Ti-6Al-4V (TC4) substrate. Characterization using scanning electron microscopy, transmission electron microscopy, and three-dimensional atom probe tomography illustrates that NPs are distributed more homogeneously on the surface of TC4 as the groove depth increases, and silver-rich NPs with a size from 10 to 20 nm exist as metallic silver diffused into the substrate, where the silver content is 4. Read More

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http://dx.doi.org/10.1021/acsami.8b16343DOI Listing
December 2018
1 Read

Assembly of Metal-Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial, and Anticoagulant Coatings.

ACS Appl Mater Interfaces 2018 Nov 16;10(47):40844-40853. Epub 2018 Nov 16.

Key Laboratory of Advanced Technology for Materials of Education Ministry, School of Materials Science and Engineering , Southwest Jiaotong University , Chengdu 610031 , China.

The development of a facile and versatile strategy to endow surfaces with synergistically anti-inflammatory, antimicrobial, and anticoagulant functions is of particular significance for blood-contacting biomaterials and medical devices. In this work, we report a simple and environmentally friendly "one-pot" method inspired by byssal cuticle chemistry, namely, [Fe(dopa)] coordination chemistry for assembly of copper ions (Cu) and plant polyphenol (tannic acid)/catecholamine (dopamine or norepinephrine) to form metal-phenolic/catecholamine network-based coatings. This one-pot method enabled us to easily develop a multifunctional surface based on the combination of the characteristic functions of metal ions and plant polyphenol or catecholamine. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b14409
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http://dx.doi.org/10.1021/acsami.8b14409DOI Listing
November 2018
15 Reads
6.723 Impact Factor

Bioactive Carbon-Based Hybrid 3D Scaffolds for Osteoblast Growth.

ACS Appl Mater Interfaces 2018 Dec 4;10(50):43874-43886. Epub 2018 Dec 4.

Institute of Biomaterials, Department of Materials Science and Engineering , University of Erlangen-Nuremberg , Cauerstr. 6 , 91058 Erlangen , Germany.

Bone, nerve, and heart tissue engineering place high demands on the conductivity of three-dimensional (3D) scaffolds. Fibrous carbon-based scaffolds are excellent material candidates to fulfill these requirements. Here, we show that highly porous (up to 94%) hybrid 3D framework structures with hierarchical architecture, consisting of microfiber composites of self-entangled carbon nanotubes (CNTs) and bioactive nanoparticles are highly suitable for growing cells. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b13631
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http://dx.doi.org/10.1021/acsami.8b13631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302313PMC
December 2018
14 Reads

In Situ Proapoptotic Peptide-Generating Rapeseed Protein-Based Nanocomplexes Synergize Chemotherapy for Cathepsin-B Overexpressing Breast Cancer.

ACS Appl Mater Interfaces 2018 Dec 21;10(48):41056-41069. Epub 2018 Nov 21.

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy , University of Toronto , 144 College Street , Toronto M5S 3M2 , Canada.

Intracellular activation of nanomaterials within cancer cells presents a powerful means to enhance anticancer specificity and efficacy. In light of upregulated lysosomal protease cathepsin-B (CathB) in many types of invasive cancer cells, herein, we exploit CathB-catalyzed biodegradation of acetylated rapeseed protein isolate (ARPI) to design polymer-drug nanocomplexes that can produce proapoptotic peptides in situ and synergize chemotherapy. ARPI forms nanocomplexes with chitosan (CS) and anticancer drug doxorubicin (DOX) [DOX-ARPI/CS nanoparticles (NPs)] by ionic self-assembly. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b14001
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http://dx.doi.org/10.1021/acsami.8b14001DOI Listing
December 2018
40 Reads

Versatile Hyperbranched Poly(β-hydrazide ester) Macromers as Injectable Antioxidative Hydrogels.

ACS Appl Mater Interfaces 2018 Nov 12;10(46):39494-39504. Epub 2018 Nov 12.

Charles Institute of Dermatology, School of Medicine , University College Dublin , Belfield, Dublin 4 , Ireland.

Synthetic reactive oxygen species (ROS)-responsive biomaterials have emerged as a useful platform for regulating critical aspects of ROS-induced pathologies and can improve such hostile microenvironments. Here, we report a series of new hyperbranched poly(β-hydrazide ester) macromers (HB-PBHEs) with disulfide moieties synthesized via an "A2 + B4" Michael addition approach. The three-dimensional structure of HB-PBHEs with multiacrylate end groups endows the macromers with rapid gelation capabilities to form (1) injectable hydrogels via cross-linking with thiolated hyaluronic acid and (2) robust UV-cross-linked hydrogels. Read More

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http://dx.doi.org/10.1021/acsami.8b15006DOI Listing
November 2018
6.723 Impact Factor

High-Throughput Assessment and Modeling of a Polymer Library Regulating Human Dental Pulp-Derived Stem Cell Behavior.

ACS Appl Mater Interfaces 2018 Nov 5;10(45):38739-38748. Epub 2018 Nov 5.

ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, Future Industries Institute , University of South Australia , Mawson Lakes , South Australia 5095 , Australia.

The identification of biomaterials that modulate cell responses is a crucial task for tissue engineering and cell therapy. The identification of novel materials is complicated by the immense number of synthesizable polymers and the time required for testing each material experimentally. In the current study, polymeric biomaterial-cell interactions were assessed rapidly using a microarray format. Read More

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http://dx.doi.org/10.1021/acsami.8b12473DOI Listing
November 2018
1 Read
6.723 Impact Factor

Biodegradable Anisotropic Microparticles for Stepwise Cell Adhesion and Preparation of Janus Cell Microparticles.

ACS Appl Mater Interfaces 2018 Oct 16;10(43):36776-36785. Epub 2018 Oct 16.

MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , China.

The biomimetic anisotropic particles have different physicochemical properties on the opposite two sides, enabling diverse applications in emulsion, photonic display, and diagnosis. However, the traditional anisotropic particles have a very small size, ranging from submicrons to a few microns. The design and fabrication of anisotropic macron-sized particles with new structures and properties is still challenging. Read More

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http://pubs.acs.org/doi/10.1021/acsami.8b14884
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http://dx.doi.org/10.1021/acsami.8b14884DOI Listing
October 2018
3 Reads