573 results match your criteria Acs Biomaterials Science & Engineering[Journal]


Toward Automated Inventory Modeling in Life Cycle Assessment: The Utility of Semantic Data Modeling to Predict Real-World Chemical Production.

ACS Sustain Chem Eng 2017 Dec;6(2):1961-1976

U.S. Environmental Protection Agency, National Risk Management Research Laboratory, 26 West Martin Luther King Drive, Cincinnati, Ohio 45268, United States.

A set of coupled semantic data models, i.e., ontologies, are presented to advance a methodology toward automated inventory modeling of chemical manufacturing in life cycle assessment. Read More

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http://dx.doi.org/10.1021/acssuschemeng.7b03379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336534PMC
December 2017

Remotely Triggered Liquefaction of Hydrogel Materials.

ACS Nano 2020 Jul 2. Epub 2020 Jul 2.

Department of Chemistry, Aarhus University, Aarhus 8000, Denmark.

Adaptable behavior such as triggered disintegration affords a broad scope and utility for (bio)materials in diverse applications in materials science and engineering. The impact of such materials continues to grow due to the increased importance of environmental considerations as well as the increased use of implants in medical practices. However, examples of such materials are still few. Read More

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http://dx.doi.org/10.1021/acsnano.0c04522DOI Listing

Dual-Modal Therapeutic Role of the Lactate Oxidase-Embedded Hierarchical Porous Zeolitic Imidazolate Framework as a Nanocatalyst for Effective Tumor Suppression.

ACS Appl Mater Interfaces 2020 Jul 8. Epub 2020 Jul 8.

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen, Fujian 361005, P. R. China.

The increasing evidence supports the fact that lactate in the tumor microenvironment (TME) plays a vital role in tumor proliferation, metastasis, and recurrence, which in turn is emerging as one of the most interesting molecular targets for tumor treatment. Here, hierarchical porous zeolitic imidazolate framework-8 (ZIF-8) as the nanocarrier is fabricated to simultaneously load lactate oxidase (LOD) and FeO nanoparticles (NPs), called LOD & FeO@ZIF-8 NPs (LFZ NPs), for tumor therapy. On one hand, the sharp consumption of lactate in the TME by LOD will change the essential "soil" where tumor cells live so as to suppress tumor rapid growth. Read More

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http://dx.doi.org/10.1021/acsami.0c05783DOI Listing

Nonenzyme Cascaded Amplification Biosensor Based on Effective Aggregation Luminescence Caused by Disintegration of Silver Nanoparticles.

ACS Sens 2020 Jul 7. Epub 2020 Jul 7.

Department of Chemistry, Department of Chemical and Biological Engineering, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China.

Sensitive and portable quantification of biomarkers has particular significance in the monitoring and treatment of clinical diseases. Conventional immunoassays were accustomed to introducing or incorporating enzymes for signal amplification, which commonly suffered from poor stability and inferior tolerance. Herein, we constructed a novel nonenzyme amplification methodology based on fluorogenic Ag-tetrazolate aggregation coupled with silver corrosion sensitization for biomarker determination. Read More

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http://dx.doi.org/10.1021/acssensors.9b02355DOI Listing

Physicochemical Tools for Visualizing and Quantifying Cell-Generated Forces.

ACS Chem Biol 2020 Jun 26. Epub 2020 Jun 26.

School of Chemistry, School of Materials Science and Engineering, Australian Centre for Nanomedicine, University of New South Wales, Sydney, New South Wales 2052, Australia.

To discern how mechanical forces coordinate biological outcomes, methods that map cell-generated forces in a spatiotemporal manner, and at cellular length scales, are critical. In their native environment, whether it be within compact multicellular three-dimensional structures or sparsely populated fibrillar networks of the extracellular matrix, cells are constantly exposed to a slew of physical forces acting on them from all directions. At the same time, cells exert highly localized forces of their own on their surroundings and on neighboring cells. Read More

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http://dx.doi.org/10.1021/acschembio.0c00304DOI Listing

Zinc-Calcium-Fluoride Bioglass-Based Innovative Multifunctional Dental Adhesive with Thick Adhesive Resin Film Thickness.

ACS Appl Mater Interfaces 2020 Jul 26;12(27):30120-30135. Epub 2020 Jun 26.

Department of Oral Health Sciences, BIOMAT & UZ Leuven (University Hospitals Leuven), Dentistry, KU Leuven (University of Leuven), , 3000 Leuven, Belgium.

Apart from producing high bond strength to tooth enamel and dentin, a dental adhesive with biotherapeutic potential is clinically desirable, aiming to further improve tooth restoration longevity. In this laboratory study, an experimental two-step universal adhesive, referred to as Exp_2UA, applicable in both the etch-and-rinse (E&R) and self-etch (SE) modes and combining a primer, containing 10-methacryloyloxydecyldihydrogen phosphate as a functional monomer with chemical binding potential to hydroxyapatite, with a bioglass-containing hydrophobic adhesive resin, was multifactorially investigated. In addition to primary property assessment, including measurement of bond strength, water sorption, solubility, and polymerization efficiency, the resultant adhesive-dentin interface was characterized by transmission electron microscopy (TEM), the filler composition was analyzed by energy-dispersive X-ray spectroscopy, and the bioactive potential of the adhesive was estimated by measuring the long-term ion release and assessing its antienzymatic and antibacterial potential. Read More

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http://dx.doi.org/10.1021/acsami.0c06865DOI Listing
July 2020
6.723 Impact Factor

Polymersomes Eradicating Intracellular Bacteria.

ACS Nano 2020 Jun 19. Epub 2020 Jun 19.

Department of Chemistry, University College London, WC1H 0AJ London, U.K.

Mononuclear phagocytes such as monocytes, tissue-specific macrophages, and dendritic cells are primary actors in both innate and adaptive immunity. These professional phagocytes can be parasitized by intracellular bacteria, turning them from housekeepers to hiding places and favoring chronic and/or disseminated infection. One of the most infamous is the bacteria that cause tuberculosis (TB), which is the most pandemic and one of the deadliest diseases, with one-third of the world's population infected and an average of 1. Read More

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http://dx.doi.org/10.1021/acsnano.0c01870DOI Listing

Wireless Electrochemotherapy by Selenium-Doped Piezoelectric Biomaterials to Enhance Cancer Cell Apoptosis.

ACS Appl Mater Interfaces 2020 Jun 23. Epub 2020 Jun 23.

School of Material Science and Engineering, South China University of Technology, Guangzhou 510006, P. R. China.

Cancer residues around the surgical site remain a significant cause of treatment failure with cancer recurrence. To prevent cancer recurrence and simultaneously repair surgery-caused defects, it is urgent to develop implantable biomaterials with anticancer ability and good biological activity. In this work, a functionalized implant is successfully fabricated by doping the effective anticancer element selenium (Se) into the potassium-sodium niobate piezoceramic, which realizes the wireless combination of electrotherapy and chemotherapy. Read More

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http://dx.doi.org/10.1021/acsami.0c04666DOI Listing

Comparison of Synthetic Neuronal Model Membrane Mimics in Amyloid Aggregation at Atomic Resolution.

ACS Chem Neurosci 2020 Jul 19;11(13):1965-1977. Epub 2020 Jun 19.

Department of Biophysics, Bose Institute, Kolkata 700054, India.

Alzheimer's disease (AD) is a severe neurodegenerative disorder caused by abnormal accumulation of toxic amyloid plaques of the amyloid-beta (Aβ) or the tau proteins in the brain. The plaque deposition leading to the collapse of the cellular integrity is responsible for a myriad of surface phenomena acting at the neuronal lipid interface. Recent years have witnessed dysfunction of the blood-brain barriers (BBB) associated with AD. Read More

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http://dx.doi.org/10.1021/acschemneuro.0c00166DOI Listing
July 2020
4.362 Impact Factor

Effects of Microstripe Geometry on Guided Cell Migration.

ACS Appl Mater Interfaces 2020 Jun 12;12(25):27971-27983. Epub 2020 Jun 12.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200438, China.

Cell migration on material surfaces is a fundament issue in the fields of biomaterials, cell biology, tissue engineering, regenerative medicine, etc. Herein, we aim to guide cell migration by flat microstripes with significant contrast of cell adhesion and varied geometric features of the adhesive stripes. To this end, we designed and fabricated cell-adhesive arginine-glycine-aspartate (RGD) microstripes on the nonfouling poly(ethylene glycol) (PEG) background and examined the microstripe-guided adhesion and migration of a few cell types. Read More

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http://dx.doi.org/10.1021/acsami.0c05024DOI Listing

Self-Assembly of Topologically Networked Protein-TiCT MXene Composites.

ACS Nano 2020 Jun 28;14(6):6956-6967. Epub 2020 May 28.

Center for Research on Advanced Fiber Technologies (CRAFT), Materials Research Institute, Pennsylvania State University, University Park, Pennsylvania 16802, United States.

Hierarchical organization plays an important role in the stunning physical properties of natural and synthetic composites. Limits on the physical properties of such composites are generally defined by percolation theory and can be systematically altered using the volumetric filler fraction of the inorganic/organic phase. In natural composites, organic materials such as proteins that interact with inorganic filler materials can further alter the hierarchical order and organization of the composite topological interactions, expanding the limits of the physical properties defined by percolation theory. Read More

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http://dx.doi.org/10.1021/acsnano.0c01431DOI Listing

All-Inkjet-Printed Flexible Nanobio-Devices with Efficient Electrochemical Coupling Using Amphiphilic Biomaterials.

ACS Appl Mater Interfaces 2020 May 12;12(21):24231-24241. Epub 2020 May 12.

Post-Silicon Semiconductor Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.

Nanostructured flexible electrodes with biological compatibility and intimate electrochemical coupling provide attractive solutions for various emerging bioelectronics and biosensor applications. Here, we develop all-inkjet-printed flexible nanobio-devices with excellent electrochemical coupling by employing amphiphilic biomaterial, an M13 phage, numerical simulation of single-drop formulation, and rational formulations of nanobio-ink. Inkjet-printed nanonetwork-structured electrodes of single-walled carbon nanotubes and M13 phage show efficient electrochemical coupling and hydrostability. Read More

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http://dx.doi.org/10.1021/acsami.0c02596DOI Listing

In Situ Interface Design in Graphene-Embedded Polymeric Silica Aerogel with Organic/Inorganic Hybridization.

ACS Appl Mater Interfaces 2020 Jun 27;12(23):26635-26648. Epub 2020 May 27.

Microcellular Plastics Manufacturing Laboratory, Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, Ontario M5S 3G8, Canada.

For many practical applications, the most important factor is to have an improved interface between the matrix and dispersed phase in a compressible composite aerogel having a high degree of porosity and a large surface area. Although some measure of compressibility is obtained in polymer-based aerogels with a continuous backbone through the hybridization of the stiff backbone [polyvinyltrimethoxysilane (P-VTMS), -C-C-] and flexible backbone [poly(3-glycidyloxypropyl)trimethoxysilane (P-GPTMS), -C-O-C-], it seems that the extent of improvement is insignificant in terms of interface improvement, surface area increase, and ordered mesoporous network. In this study, the effects of the incorporation of graphene nanoplatelets (GnPs) on aerogels made of a backbone consisting of -C-O-C- (flexible backbone) were examined in terms of structural improvement and were compared with aerogels made of a backbone consisting of -C-C- (stiff backbone). Read More

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http://dx.doi.org/10.1021/acsami.0c04531DOI Listing

3D Printing of Polyethylene Terephthalate Glycol-Sepiolite Composites with Nanoscale Orientation.

ACS Appl Mater Interfaces 2020 May 8;12(20):23453-23463. Epub 2020 May 8.

Department of Organic Materials Engineering, Chungnam National University, Daejeon 34134, Republic of Korea.

A fused-deposition modeling (FDM) 3D-printed polyethylene terephthalate glycol (PETG)-sepiolite composite showed effective synergetic mechanical reinforcement in tensile testing compared to an injection-molded composite. The results showed that the addition of 3 phr sepiolite improved the tensile strength of 3D-printed PETG samples by 35.4%, while the tensile strength of injection-molded PETG samples was improved by 7. Read More

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http://dx.doi.org/10.1021/acsami.0c03830DOI Listing

Structural Determination of a Filamentous Chaperone to Fabricate Electronically Conductive Metalloprotein Nanowires.

ACS Nano 2020 Jun 7;14(6):6559-6569. Epub 2020 May 7.

School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.

The transfer of electrons through protein complexes is central to cellular respiration. Exploiting proteins for charge transfer in a controllable fashion has the potential to revolutionize the integration of biological systems and electronic devices. Here we characterize the structure of an ultrastable protein filament and engineer the filament subunits to create electronically conductive nanowires under aqueous conditions. Read More

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http://dx.doi.org/10.1021/acsnano.9b09405DOI Listing

Highly Efficient Separation of Anionic Organic Pollutants from Water via Construction of Functional Cationic Metal-Organic Frameworks and Mechanistic Study.

ACS Appl Mater Interfaces 2020 May 8;12(20):22835-22844. Epub 2020 May 8.

School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China.

Organic anions possess various functional properties; however, their presence in wastewater causes environmental pollution. Thus, coupling the separation of such species with the resultant function could be highly desirable. Herein, we propose a "killing two birds with one stone" strategy for highly efficient separation of organic pollutant anions from water at room temperature through direct construction of functional cationic metal-organic frameworks (CMOFs) based on the organic anions as charge-balancing anions. Read More

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http://dx.doi.org/10.1021/acsami.0c02624DOI Listing

Dual-Function Antibacterial Micelle Self-Assembling Block Copolymers with Various Antibacterial Nanoparticles.

ACS Omega 2020 Apr 8;5(15):8523-8533. Epub 2020 Apr 8.

College of Pharmacy, Guangdong Lingnan Institute of Technology, Guangzhou 510663, China.

Antibacterial biomaterials with kill-resist dual functions by combining multiple active components have been constructed, with a final aim at decreasing the incidence of biomaterial-centered infection. Self-assemblies of bactericidal ZnO or Ag-ZnO nanoparticles (NPs) with triblock copolymers, poly(ethylene glycol)--poly(3-hydroxybutyrate--3-hydroxyvalerate)-poly(ethylene glycol) (PEG-PHBV-PEG), showed a hydrophobic PHBV layer on NPs with PEG segments exposed outside hydrogen bonding, resulting in long PEG ( = 2000) aggregation and short PEG ( = 1000) aggregation, respectively. These nanocomposite aggregations released ZnO or Ag-ZnO rapidly within initial few hours, and about 42-45% of NPs were left in the nanocomposites in deionized water for 16 d to improve the long-term antibacterial activity further. Read More

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http://dx.doi.org/10.1021/acsomega.9b04086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178363PMC

Virus-Inspired Mimics: Dual-pH-Responsive Modular Nanoplatforms for Programmable Gene Delivery without DNA Damage with the Assistance of Light.

ACS Appl Mater Interfaces 2020 May 8;12(20):22519-22533. Epub 2020 May 8.

Huaxi MR Research Center (HMRRC), Department of Radiology, Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.

Although tremendous efforts have been made to construct gene vectors incorporating multiple functionalities and moieties, designing gene vectors integrating innovative features to successfully negotiate biological impediments, which hamper efficacious responses in gene-based therapy, is still very urgent. Herein, a light-induced virus-inspired mimic, in which a modular envelope was utilized to mask polyethylenimine/DNA (PD) polyplexes, was developed based on two pH-responsive polymers. The virus-inspired envelope, which was capable of achieving multitargeting and dual-pH-responsiveness in endo/lysosomal compartments, was composed of an internalizing arginylglycylaspartic acid-modified module and a citraconic anhydride-modified nuclear localized signal-functionalized module. Read More

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http://dx.doi.org/10.1021/acsami.0c03486DOI Listing

Glyco-Modification of Mucin Hydrogels to Investigate Their Immune Activity.

ACS Appl Mater Interfaces 2020 Apr 17;12(17):19324-19336. Epub 2020 Apr 17.

Division of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH, Royal Institute of Technology, AlbaNova University Center, 106 91 Stockholm, Sweden.

Mucins are multifunctional glycosylated proteins that are increasingly investigated as building blocks of novel biomaterials. An attractive feature is their ability to modulate the immune response, in part by engaging with sialic acid binding receptors on immune cells. Once assembled into hydrogels, bovine submaxillary mucins (Muc gels) were shown to modulate the recruitment and activation of immune cells and avoid fibrous encapsulation . Read More

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http://dx.doi.org/10.1021/acsami.0c03645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304668PMC
April 2020
6.723 Impact Factor

Multifunctional Biomaterials: Combining Material Modification Strategies for Engineering of Cell-Contacting Surfaces.

ACS Appl Mater Interfaces 2020 May 30;12(19):21342-21367. Epub 2020 Apr 30.

Laboratory for Biointerfaces, Empa, Swiss Federal Laboratories for Materials Science and Technology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland.

In the human body, cells in a tissue are exposed to signals derived from their specific extracellular matrix (ECM), such as architectural structure, mechanical properties, and chemical composition (proteins, growth factors). Research on biomaterials in tissue engineering and regenerative medicine aims to recreate such stimuli using engineered materials to induce a specific response of cells at the interface. Although traditional biomaterials design has been mostly limited to varying individual signals, increasing interest has arisen on combining several features in recent years to improve the mimicry of extracellular matrix properties. Read More

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http://dx.doi.org/10.1021/acsami.0c01893DOI Listing

Magnetic Field-Induced Alignment of Nanofibrous Supramolecular Membranes: A Molecular Design Approach to Create Tissue-like Biomaterials.

ACS Appl Mater Interfaces 2020 May 8;12(20):22661-22672. Epub 2020 May 8.

School of Engineering and Materials Science and Institute of Bioengineering, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.

A molecular design approach to fabricate nanofibrous membranes by self-assembly of aromatic cationic peptides with hyaluronic acid (HA) and nanofiber alignment under a magnetic field is reported. Peptides are designed to contain a block composed of four phenylalanine residues at the C-terminus, to drive their self-assembly by hydrophobic association and aromatic stacking, and have a positively charged domain of lysine residues for electrostatic interaction with HA. These two blocks are connected by a linker with a variable number of amino acids and the ability to adopt distinct conformations. Read More

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http://dx.doi.org/10.1021/acsami.0c05191DOI Listing

Synthesis of Magnetite-Based Polymers as Mercury and Anion Sensors Using Single Electron Transfer-Living Radical Polymerization.

ACS Omega 2020 Apr 27;5(13):7201-7210. Epub 2020 Mar 27.

Department of Environmental Engineering and Science, Feng Chia University, Taichung 407, Taiwan.

In this work, hydrophilic polymers modified with iron oxide nanoparticles, such as iron oxide-poly(2-dimethylaminoethyl methacrylate) [P(DMAEMA)] magnetite-based and iron oxide-poly(acrylamide) [P(AAm)] magnetite-based polymers, were prepared via a single electron transfer-living radical polymerization approach. Bile acid and 2-bromo-2-methylpropionic acid were covalently attached onto the surface of FeO nanoparticles, and these immobilized magnetite nanoparticles were used as an initiator for the polymerization. The binding capabilities of different ions, such as Hg, CN, Cl, F, and NO, were tested using these polymeric sensors monitored by UV-vis spectroscopy. Read More

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http://dx.doi.org/10.1021/acsomega.9b03653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143427PMC

Mimicking the Endothelium: Dual Action Heparinized Nitric Oxide Releasing Surface.

ACS Appl Mater Interfaces 2020 May 22;12(18):20158-20171. Epub 2020 Apr 22.

School of Chemical, Materials and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.

The management of thrombosis and bacterial infection is critical to ensure the functionality of medical devices. While administration of anticoagulants is the current antithrombotic clinical practice, a variety of complications, such as uncontrolled hemorrhages or heparin-induced thrombocytopenia, can occur. Additionally, infection rates remain a costly and deadly complication associated with use of these medical devices. Read More

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http://dx.doi.org/10.1021/acsami.9b22277DOI Listing

Green Fabrication of Tannic Acid-Inspired Magnetic Composite Nanoparticles toward Cationic Dye Capture and Selective Degradation.

ACS Omega 2020 Mar 21;5(12):6566-6575. Epub 2020 Mar 21.

College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China.

An environmental strategy for developing sustainable materials presents an attractive prospect for wastewater remediation. Herein, a facile, green, and economical strategy is proposed to fabricate magnetic composite nanoparticles (NPs) toward cationic dye adsorption and selective degradation. To prepare the composite TiO-PEI-TA@FeO NPs, tannic acid (TA) and polyethyleneimine (PEI) were first used to decorate FeO NPs at aqueous solution, and then TiO NPs were anchored onto the surfaces of FeO NPs based on the catecholamine chemistry. Read More

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http://dx.doi.org/10.1021/acsomega.9b04304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114688PMC

Nanoparticle Uptake in a Spontaneous and Immunocompetent Woodchuck Liver Cancer Model.

ACS Nano 2020 Apr 14;14(4):4698-4715. Epub 2020 Apr 14.

Soham and Shaila Ajmera Family Transplant Centre, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4.

There is a tremendous focus on the application of nanomaterials for the treatment of cancer. Nonprimate models are conventionally used to assess the biomedical utility of nanomaterials. However, these animals often lack an intact immunological background, and the tumors in these animals do not develop spontaneously. Read More

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http://dx.doi.org/10.1021/acsnano.0c00468DOI Listing

Surface Tethering of Inflammation-Modulatory Nanostimulators to Stem Cells for Ischemic Muscle Repair.

ACS Nano 2020 May 13;14(5):5298-5313. Epub 2020 Apr 13.

Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

Stem cell transplantation has been a promising treatment for peripheral arterial diseases in the past decade. Stem cells act as living bioreactors of paracrine factors that orchestrate tissue regeneration. Prestimulated adipose-derived stem cells (ADSCs) have been proposed as potential candidates but have been met with challenges in activating their secretory activities for clinical use. Read More

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http://dx.doi.org/10.1021/acsnano.9b04926DOI Listing

Interfacial Engineering of a Heteroatom-Doped Graphene Layer on Patterned Aluminum Foil for Ultrafast Lithium Storage Kinetics.

ACS Appl Mater Interfaces 2020 Apr 10;12(16):19210-19217. Epub 2020 Apr 10.

Program of Materials Science & Engineering, Convergence Institute of Biomedical Engineering and Biomaterials, Seoul National University of Science and Technology, Seoul 01811, Korea.

The design of the interfacial architecture between the electrode and the current collector in lithium-ion batteries (LIB) plays a key role in achieving ultrafast lithium storage kinetics with respect to efficient charge transfer and cycle stability. However, in recent years, despite considerable efforts in the structural and chemical engineering of active materials (anode and cathode materials), interfacial architectures between the electrode and the current collector have received relatively insufficient attention in the case of ultrafast LIBs. Here, the interface architecture of a micropatterned Al current collector with a heteroatom-doped graphene interfacial layer is developed using roll pressing and dip coating processes. Read More

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http://dx.doi.org/10.1021/acsami.0c01774DOI Listing

Glycoengineering of Natural Killer Cells with CD22 Ligands for Enhanced Anticancer Immunotherapy.

ACS Cent Sci 2020 Mar 5;6(3):382-389. Epub 2020 Mar 5.

Departments of Chemistry and Biomedical Engineering, Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.

Adoptive transfer of immune cells is being actively pursued for cancer treatment. Natural killer (NK) cells, a class of cytotoxic immune cells, generally lack inherent selectivities toward cancer. To bestow tumor-targeting abilities and enhance anticancer efficacy, a new strategy is established to glycoengineer NK cells. Read More

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http://dx.doi.org/10.1021/acscentsci.9b00956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7099595PMC

Biomimetic Presentation of Cryptic Ligands Single-Chain Nanogels for Synergistic Regulation of Stem Cells.

ACS Nano 2020 Apr 3;14(4):4027-4035. Epub 2020 Apr 3.

Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong SAR 999077, P.R. China.

Dynamic controlling the nanoscale presentation of synergistic ligands to stem cells by biomimetic single-chain materials can provide critical insights to understand the molecular crosstalk underlying cells and their extracellular matrix. Here, a stimuli-responsive single-chain macromolecular nanoregulator with conformational dynamics is fabricated based on an advanced scale-up single polymeric chain nanogel (SCNG). Such a carefully designed SCNG is capable of mediating a triggered copresentation of the master and cryptic ligands in a single molecule to elicit the synergistic crosstalk between different intracellular signaling pathways, thereby considerably boosting the bioactivity of the presented ligands. Read More

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http://dx.doi.org/10.1021/acsnano.9b08564DOI Listing

Diagnosing COVID-19: The Disease and Tools for Detection.

ACS Nano 2020 04 30;14(4):3822-3835. Epub 2020 Mar 30.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5S 3G9, Canada.

COVID-19 has spread globally since its discovery in Hubei province, China in December 2019. A combination of computed tomography imaging, whole genome sequencing, and electron microscopy were initially used to screen and identify SARS-CoV-2, the viral etiology of COVID-19. The aim of this review article is to inform the audience of diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics. Read More

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http://dx.doi.org/10.1021/acsnano.0c02624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144809PMC
April 2020
12.881 Impact Factor

Stable Fabrication of Zwitterionic Coating Based on Copper-Phenolic Networks on Contact Lens with Improved Surface Wettability and Broad-Spectrum Antimicrobial Activity.

ACS Appl Mater Interfaces 2020 Apr 27;12(14):16125-16136. Epub 2020 Mar 27.

National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China.

Ocular dryness and contact lens(CL)-related microbial keratitis (MK) are two major risks of wearing CLs. The development of multifunctional surface coating for CLs with excellent hydrating and antimicrobial properties is a practical strategy to improve the comfort of CL wearers and to prevent corneal infection. Here, we develop zwitterionic and antimicrobial metal-phenolic networks (MPNs) based on the coordination of copper ions (Cu) and the poly(carboxylbetaine--dopamine methacrylamide) copolymer (PCBDA), which can be easily one-step prepared onto CLs due to the near-universal adherent properties of catechol groups. Read More

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http://dx.doi.org/10.1021/acsami.0c02143DOI Listing

Prolonged UV-C Irradiation is a Double-Edged Sword on the Zirconia Surface.

ACS Omega 2020 Mar 5;5(10):5126-5133. Epub 2020 Mar 5.

Dental Materials Science, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Pokfulam, Hong Kong SAR, P.R. China.

Zirconia has become an excellent choice of dental implants because of its excellent mechanical strength, aesthetic, and biocompatibility. Although some studies have shown ultraviolet (UV) irradiation is effective to photofunctionalize dental zirconia that can improve osteoblastic function, the scattered information has not identified the most effective exposure time and wavelength of UV. Herein, this study has investigated the effects of UV irradiation on zirconia after UV-A (365 nm) or UV-C (243 nm) photofunctionalization for different times (15 min, 3 and 24 h). Read More

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http://dx.doi.org/10.1021/acsomega.9b04123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081443PMC

Facile and Novel Eco-Friendly Poly(Vinyl Alcohol) Nanofilters Using the Photocatalytic Property of Titanium Dioxide.

ACS Omega 2020 Mar 6;5(10):5026-5033. Epub 2020 Mar 6.

Department of Biosystems & Biomaterials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.

This study aimed to develop a highly efficient nanofilter for capturing fine particles using electrostatic forces. Poly(vinyl alcohol) (PVA), a water-soluble synthetic polymer, was selected as the main component of the filter because it can be easily fabricated by electrospinning. Titanium dioxide (TiO) nanopowder with an anatase structure was applied to the nanofilters as it has the highest photocatalytic activity among the existing photocatalysts. Read More

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http://dx.doi.org/10.1021/acsomega.9b03944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081405PMC

Morphological Transitions in Patchy Nanoparticles.

ACS Nano 2020 Apr 20;14(4):4577-4584. Epub 2020 Mar 20.

Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada.

Nanoparticles (NPs) decorated with topographically or chemically distinct surface patches are an emerging class of colloidal building blocks of functional hierarchical materials. Surface segregation of polymer ligands into pinned micelles offers a strategy for the generation of patchy NPs with controlled spatial distribution and number of patches. The thermodynamic nature of this approach poses a question about the stability of multiple patches on the NP surface, as the lowest energy state is expected for NPs carrying a single patch. Read More

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http://dx.doi.org/10.1021/acsnano.0c00108DOI Listing

Multifunctional Antimicrobial Nanofiber Dressings Containing ε-Polylysine for the Eradication of Bacterial Bioburden and Promotion of Wound Healing in Critically Colonized Wounds.

ACS Appl Mater Interfaces 2020 Apr 27;12(14):15989-16005. Epub 2020 Mar 27.

Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, 169856 Singapore.

Bacterial colonization of acute and chronic wounds is often associated with delayed wound healing and prolonged hospitalization. The rise of multi-drug resistant bacteria and the poor biocompatibility of topical antimicrobials warrant safe and effective antimicrobials. Antimicrobial agents that target microbial membranes without interfering with the mammalian cell proliferation and migration hold great promise in the treatment of traumatic wounds. Read More

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http://dx.doi.org/10.1021/acsami.9b21683DOI Listing

Tumor-Specific Endogenous Fe-Activated, MRI-Guided Self-Targeting Gadolinium-Coordinated Theranostic Nanoplatforms for Amplification of ROS and Enhanced Chemodynamic Chemotherapy.

ACS Appl Mater Interfaces 2020 Apr 18;12(13):14884-14904. Epub 2020 Mar 18.

Department of Biomaterials, College of Materials, Research Center of Biomedical Engineering of Xiamen & Key Laboratory of Biomedical Engineering of Fujian Province & Fujian Provincial Key Laboratory for Soft Functional Materials Research, Xiamen University, Xiamen 361005, China.

Low drug payload and lack of tumor-targeting for chemodynamic therapy (CDT) result in an insufficient reactive oxygen species (ROS) generation, which seriously hinders its further clinical application. Therefore, how to improve the drug payload and tumor targeting for amplification of ROS and combine it with chemotherapy has been a huge challenge in CDT. Herein, methotrexate (MTX), gadolinium (Gd), and artesunate (ASA) were used as theranostic building blocks to be coordinately assembled into tumor-specific endogenous Fe-activated and magnetic resonance imaging (MRI)-guided self-targeting carrier-free nanoplatforms (NPs) for amplification of ROS and enhanced chemodynamic chemotherapy. Read More

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http://dx.doi.org/10.1021/acsami.0c00970DOI Listing

Green Gas-Mediated Cross-Linking Generates Biomolecular Hydrogels with Enhanced Strength and Excellent Hemostasis for Wound Healing.

ACS Appl Mater Interfaces 2020 Mar 12;12(12):13622-13633. Epub 2020 Mar 12.

Department of Chemistry and Biochemistry, Stephenson Life Science Research Center, University of Oklahoma, Norman, Oklahoma 73019, United States.

Forming biomolecular hydrogels with a combination of high strength and biocompatibility is still a challenge. Herein, we demonstrated a green gas (CO)-mediated chemical cross-linking strategy that can produce a double-network cellulose/silk fibroin hydrogel (CSH) with significantly elevated mechanical strength while bypassing the toxicity of routine cross-linking agents. Specifically, cellulose and silk fibroin (SF) were first covalently cross-linked in NaOH/urea solution to create the primary network. Read More

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http://dx.doi.org/10.1021/acsami.9b21325DOI Listing

Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery.

ACS Appl Mater Interfaces 2020 Apr 17;12(13):14946-14957. Epub 2020 Mar 17.

Department of Chemistry in Pharmaceutical Sciences, Faculty of Pharmacy, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.

In this work, two types of mesoporous carbon particles with different morphology, size, and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their textural properties allow significantly higher loading capacity compared to typical mesoporous silica nanoparticles. In vial release experiments of a model Ru dye at pH 7. Read More

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http://dx.doi.org/10.1021/acsami.0c01786DOI Listing

Hierarchically Chiral Lattice Self-Assembly Induced Circularly Polarized Luminescence.

ACS Nano 2020 Mar 10;14(3):3190-3198. Epub 2020 Mar 10.

CAS Center for Excellence in Nanoscience, CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology (NCNST), Beijing 100190, People's Republic of China.

Biomaterials in nature often exhibit hierarchical chiral structures with an intriguing mechanism involving hierarchical chirality transfer from molecular to supramolecular and the nano- or microscale level. To mimic the cross-level chirality transfer, we present here one kind of host-guest complex system built of β-cyclodextrin (β-CD), sodium dodecyl sulfate (SDS), and fluorescent dyes, which show multilevel chirality, including molecular chirality of β-CD, induced supramolecular chirality of β-CD/SDS host-guest complexes, a chiral lattice self-assembled nanosheet, mesoscopic chirality of an assembled helical tube, induced chirality of a dye-doped chiral tube. The hierarchical chirality involved a chiral lattice self-assembly process, which can be identified by small-angle X-ray scattering, optical studies, circular dichroism, and circularly polarized luminescence spectral measurements. Read More

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http://dx.doi.org/10.1021/acsnano.9b08408DOI Listing

Improving Mechanical Properties and Biocompatibilities by Highly Oriented Long Chain Branching Poly(lactic acid) with Bionic Surface Structures.

ACS Appl Mater Interfaces 2020 Mar 13;12(12):14365-14375. Epub 2020 Mar 13.

Department of Orthopedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200433, P. R. China.

Exploiting the solid-state drawing (SSD) process toward polymer materials for medical implant devices is of significance to simultaneously improve the mechanical property and biocompatibility. Herein, for the first time, the bionic implants with a microvalley surface of oriented long chain branching PLA (b-PLA) was fabricated by a feasible SSD process. The as-obtained b-PLAs could not only show a high tensile strength (278. Read More

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http://dx.doi.org/10.1021/acsami.9b20264DOI Listing

Boosting the Osteogenic and Angiogenic Performance of Multiscale Porous Polycaprolactone Scaffolds by Generated Extracellular Matrix Decoration.

ACS Appl Mater Interfaces 2020 Mar 9;12(11):12510-12524. Epub 2020 Mar 9.

Department of Materials Science and Engineering, Kroto Research Institute, University of Sheffield, Sheffield S3 7HQ, United Kingdom.

Tissue engineering (TE)-based bone grafts are favorable alternatives to autografts and allografts. Both biochemical properties and the architectural features of TE scaffolds are crucial in their design process. Synthetic polymers are attractive biomaterials to be used in the manufacturing of TE scaffolds, due to various advantages, such as being relatively inexpensive, enabling precise reproducibility, possessing tunable mechanical/chemical properties, and ease of processing. Read More

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http://dx.doi.org/10.1021/acsami.9b23100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146758PMC

Universal Strategy for Efficient Fabrication of Blood Compatible Surfaces via Polydopamine-Assisted Surface-Initiated Activators Regenerated by Electron Transfer Atom-Transfer Radical Polymerization of Zwitterions.

ACS Appl Mater Interfaces 2020 Mar 25;12(10):12337-12344. Epub 2020 Feb 25.

Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an 710127, Shaanxi, P. R. China.

Implant and blood-contacting biomaterials are challenged by biofouling and thrombus formation at their interface. Zwitterionic polymer brush coating can achieve excellent hemocompatibility, but the preparation often involves tedious, expensive, and complicated procedures that are designed for specific substrates. Here, we report a facile and universal strategy of creating zwitterionic polymer brushes on variety of materials by polydopamine (PDA)-assisted and surface-initiated activators regenerated by electron transfer atom-transfer radical polymerization (PDA-SI-ARGET-ATRP). Read More

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http://dx.doi.org/10.1021/acsami.9b22574DOI Listing

Sperm Micromotors for Cargo Delivery through Flowing Blood.

ACS Nano 2020 03 4;14(3):2982-2993. Epub 2020 Mar 4.

Institute for Integrative Nanosciences, Leibniz IFW Dresden, Helmholtzstraße 20, 01069 Dresden, Germany.

Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo delivery in complex biological environments. However, their feasibility in the circulatory system has been limited due to the low thrust force exhibited by many of the reported synthetic micromotors, which is not sufficient to overcome the high flow and complex composition of blood. Here we present a hybrid sperm micromotor that can actively swim against flowing blood (continuous and pulsatile) and perform the function of heparin cargo delivery. Read More

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http://dx.doi.org/10.1021/acsnano.9b07851DOI Listing

Fibrin Glue/Fibronectin/Heparin-Based Delivery System of BMP2 Induces Osteogenesis in MC3T3-E1 Cells and Bone Formation in Rat Calvarial Critical-Sized Defects.

ACS Appl Mater Interfaces 2020 Mar 4;12(11):13400-13410. Epub 2020 Mar 4.

Department of Neurosurgery, Teikyo University School of Medicine, Tokyo 163-8001, Japan.

Bone morphogenetic proteins (BMPs) have been used to promote bone formation in many clinical scenarios. However, the BMPs are inherently unstable and therefore need to be combined with carriers for controlled delivery. In this study, an innovative and efficient fibrin glue/fibronectin/heparin (FG/Fn/Hep)-based delivery system was developed for controlled release of BMP2. Read More

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http://dx.doi.org/10.1021/acsami.0c01371DOI Listing

Recent Advances in Applications of Voltammetric Sensors Modified with Ferrocene and Its Derivatives.

ACS Omega 2020 Feb 28;5(5):2049-2059. Epub 2020 Jan 28.

Department of Materials Science and Engineering, Research Institute of Advanced Materials, Seoul National University, Seoul 08826, Republic of Korea.

This study is on current developments concerning ferrocene (FC) and its derivatives on the basis of electrochemical biosensors and sensors. The distinct physiochemical characteristics of FC have enabled the development of new sensor devices, specifically electrochemical sensors. Several articles have focused on the implementation of FC as an electrode constituent while discussing its electrochemical behavior. Read More

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http://dx.doi.org/10.1021/acsomega.9b03788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016907PMC
February 2020

Seeding the Self-Assembly of DNA Origamis at Surfaces.

ACS Nano 2020 May 19;14(5):5203-5212. Epub 2020 Feb 19.

Chemistry and Chemical Biology, University of California, Merced, California 95343, United States.

Unlike supramolecular self-assembly methods that can organize many distinct components into designer shapes in a homogeneous solution (e.g., DNA origami), only relatively simple, symmetric structures consisting of a few distinct components have been self-assembled at solid surfaces. Read More

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http://dx.doi.org/10.1021/acsnano.9b09348DOI Listing

Increasing the Potential Interacting Area of Nanomedicine Enhances Its Homotypic Cancer Targeting Efficacy.

ACS Nano 2020 03 21;14(3):3259-3271. Epub 2020 Feb 21.

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585 Singapore.

The cancer cell membrane contains an arsenal of highly specific homotypic moieties that can be used to recognize its own kind. These cell membranes are often used to coat spherical nanoparticles to enhance nanomedicines' targeting specificities and uptakes. A sphere, however, has only a point contact with a surface at any given time. Read More

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http://dx.doi.org/10.1021/acsnano.9b08798DOI Listing

Targeting Pathogenic Biofilms: Newly Developed Superhydrophobic Coating Favors a Host-Compatible Microbial Profile on the Titanium Surface.

ACS Appl Mater Interfaces 2020 Mar 24;12(9):10118-10129. Epub 2020 Feb 24.

Department of Prosthodontics and Periodontology, Piracicaba Dental School, University of Campinas (UNICAMP), 901 Limeira Avenue, Piracicaba, São Paulo 13414-903, Brazil.

Polymicrobial infections are one of the most common reasons for inflammation of surrounding tissues and failure of implanted biomaterials. Because microorganism adhesion is the first step for biofilm formation, physical-chemical modifications of biomaterials have been proposed to reduce the initial microbial attachment. Thus, the use of superhydrophobic coatings has emerged because of their anti-biofilm properties. Read More

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http://dx.doi.org/10.1021/acsami.9b22741DOI Listing
March 2020
6.723 Impact Factor

Electrodeposited Assembly of Additive-Free Silk Fibroin Coating from Pre-Assembled Nanospheres for Drug Delivery.

ACS Appl Mater Interfaces 2020 Mar 25;12(10):12018-12029. Epub 2020 Feb 25.

Department of Dentistry-Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, The Netherlands.

Electrophoretically deposited (EPD) polymer-based coatings have been extensively reported as reservoirs in medical devices for delivery of therapeutic agents, but control over drug release remains a challenge. Here, a simple but uncommon assembly strategy for EPD polymer coatings was proposed to improve drug release without introducing any additives except the EPD matrix polymer precursor. The added value of the proposed strategy was demonstrated by developing a novel EPD silk fibroin (SF) coating assembled from pre-assembled SF nanospheres for an application model, that is, preventing infections around percutaneous orthopedic implants via local delivery of antibiotics. Read More

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http://dx.doi.org/10.1021/acsami.9b21808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068717PMC

Bioactive Anti-inflammatory, Antibacterial, Antioxidative Silicon-Based Nanofibrous Dressing Enables Cutaneous Tumor Photothermo-Chemo Therapy and Infection-Induced Wound Healing.

ACS Nano 2020 03 27;14(3):2904-2916. Epub 2020 Feb 27.

National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710000, China.

Traditional skin tumor surgery and chronic bacterial-infection-induced wound healing/skin regeneration is still a challenge. The ideal strategy should eliminate the tumor, enhance wound healing/skin formation, and be anti-infection. Herein, we designed a multifunctional elastomeric poly(l-lactic acid)-poly(citrate siloxane)-curcumin@polydopamine hybrid nanofibrous scaffold (denoted as PPCP matrix) for tumor-infection therapy and infection-induced wound healing. Read More

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http://dx.doi.org/10.1021/acsnano.9b07173DOI Listing