588,586 results match your criteria Across Languages And Cultures[Journal]


Impact of Deployment on Reproductive Health in U.S. Active-Duty Servicewomen and Veterans.

Semin Reprod Med 2018 Nov 19;36(6):361-370. Epub 2019 Apr 19.

Informatics, Decision Enhancement, and Analytic Sciences (IDEAS) Center, VA Salt Lake City Health Care System, Salt Lake City, Utah.

Reproductive-age women are a fast-growing component of active-duty military personnel who experience deployment and combat more frequently than previous service-era women Veterans. With the expansion of the number of women and their roles, the United States Departments of Defense and Veterans Affairs have prioritized development and integration of reproductive services into their health systems. Thus, understanding associations between deployments or combat exposures and short- or long-term adverse reproductive health outcomes is imperative for policy and programmatic development. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678749
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http://dx.doi.org/10.1055/s-0039-1678749DOI Listing
November 2018
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Preconception Care in the Veterans Health Administration.

Semin Reprod Med 2018 Nov 19;36(6):327-339. Epub 2019 Apr 19.

VA Central Office, Women's Health Services, Washington, District of Columbia.

Preconception care (PCC), defined as a set of interventions to help women optimize their health and well-being prior to pregnancy, can improve pregnancy outcomes and is recommended by national organizations including the Centers for Disease Control and Prevention and the American College of Obstetricians and Gynecologists. Women Veterans who use the Department of Veterans Affairs (VA) health care system may face elevated risks of adverse pregnancy and birth outcomes due to a high prevalence of chronic medical and mental health conditions as well as psychosocial stressors including sexual trauma history and intimate partner violence. Many women Veterans of childbearing age experience poverty and homelessness, which are key social determinants of poor reproductive health outcomes. Read More

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http://dx.doi.org/10.1055/s-0039-1678753DOI Listing
November 2018

Reproductive Health of Women Veterans: A Systematic Review of the Literature from 2008 to 2017.

Semin Reprod Med 2018 Nov 19;36(6):315-322. Epub 2019 Apr 19.

Division of Gynecology, Department of Surgery, VA Boston Healthcare System, Boston, Massachusetts.

The literature on the reproductive health and healthcare of women Veterans has increased dramatically, though there are important gaps. This article aims to synthesize recent literature on reproductive health and healthcare of women Veterans. We updated a literature search to identify manuscripts published between 2008 and July 1, 2017. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0039-1678750
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http://dx.doi.org/10.1055/s-0039-1678750DOI Listing
November 2018
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Natural history of neuromodulation devices and therapies: a patient-centered survival analysis.

J Neurosurg 2019 Apr 19:1-7. Epub 2019 Apr 19.

OBJECTIVEDespite rapid development and expansion of neuromodulation technologies, knowledge about device and/or therapy durability remains limited. The aim of this study was to evaluate the long-term rate of hardware and therapeutic failure of implanted devices for several neuromodulation therapies.METHODSThe authors performed a retrospective analysis of patients' device and therapy survival data (Kaplan-Meier survival analysis) for deep brain stimulation (DBS), vagus nerve stimulation (VNS), and spinal cord stimulation (SCS) at a single institution (years 1994-2015). Read More

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https://thejns.org/view/journals/j-neurosurg/aop/article-10.
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http://dx.doi.org/10.3171/2019.2.JNS182450DOI Listing
April 2019
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Independent component analysis based algorithms for high-density electromyogram decomposition: Experimental evaluation of upper extremity muscles.

Comput Biol Med 2019 Mar 13;108:42-48. Epub 2019 Mar 13.

Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, North Carolina State University, United States. Electronic address:

Motor unit firing activities can provide critical information regarding neural control of skeletal muscles. Extracting motor unit activities reliably from surface electromyogram (EMG) is still a challenge in signal processing. We quantified the performance of three different independent component analysis (ICA)-based decomposition algorithms (Infomax, FastICA and RobustICA) on high-density EMG signals, obtained from arm muscles (biceps brachii and extensor digitorum communis) at different contraction levels. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193008
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.009DOI Listing
March 2019
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Co-assembled Ca Alginate-Sulfate Nanoparticles for Intracellular Plasmid DNA Delivery.

Mol Ther Nucleic Acids 2019 Mar 28;16:378-390. Epub 2019 Mar 28.

Avram and Stella Goldstein-Goren Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel; The Ilse Katz Institute for Nanoscale Science and Technology, Ben-Gurion University of the Negev, Beer-Sheva 8410501, Israel. Electronic address:

Successful gene therapy requires the development of suitable carriers for the selective and efficient delivery of genes to specific target cells, with minimal toxicity. In this work, we present a non-viral vector for gene delivery composed of biocompatible materials, CaCl, plasmid DNA and the semi-synthetic anionic biopolymer alginate sulfate (AlgS), which spontaneously co-assembled to form nanoparticles (NPs). The NPs were characterized with a slightly anionic surface charge (Zeta potential [ζ] = -14 mV), an average size of 270 nm, and their suspension was stable for several days with no aggregation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21622531193006
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http://dx.doi.org/10.1016/j.omtn.2019.03.006DOI Listing
March 2019
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Microplastic pollution in streams spanning an urbanisation gradient.

Environ Pollut 2019 Apr 2;250:292-299. Epub 2019 Apr 2.

School of Environment, University of Auckland, Auckland, New Zealand.

Microplastic pollution has received considerable attention in marine systems, but recent work shows substantial plastic pollution also occurs in freshwater ecosystems. Most freshwater research has focused on large rivers and lakes, but small streams are the primary interface between land, where plastic is used, and drainage networks. We examined variation in the amount and form of plastic occurring in small streams spanning an urbanisation gradient. Read More

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http://dx.doi.org/10.1016/j.envpol.2019.03.105DOI Listing

The forgotten role of toxicodynamics: How habitat quality alters the mite, Oppia nitens, susceptibility to zinc, independent of toxicokinetics.

Chemosphere 2019 Apr 13;227:444-454. Epub 2019 Apr 13.

Toxicology Centre, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5B3; Department of Soil Science, University of Saskatchewan, Saskatoon, SK, Canada, S7N 5A8.

Soil habitat quality is thought to influence metal toxicity via changes in speciation and thereby toxicokinetics. Here, we assessed the toxicokinetic and toxicodynamic effects of habitat quality on mite, Oppia nitens when exposed to zinc (Zn) contaminated soils. Forty-seven soils were ranked into three habitat qualities; high, medium, and low based on biological reproduction of Folsomia candida, Enchytraeus crypticus, and Elymus lanceolatus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00456535193074
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http://dx.doi.org/10.1016/j.chemosphere.2019.04.090DOI Listing
April 2019
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A comprehensive assessment of stream fragmentation in Great Britain.

Sci Total Environ 2019 Apr 10;673:756-762. Epub 2019 Apr 10.

Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

Artificial barriers are one of the main threats to river ecosystems, resulting in habitat fragmentation and loss of connectivity. Yet, the abundance and distribution of most artificial barriers, excluding high-head dams, is poorly documented. We provide a comprehensive assessment of the distribution and typology of artificial barriers in Great Britain, and estimate for the first time the extent of river fragmentation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
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http://dx.doi.org/10.1016/j.scitotenv.2019.04.125DOI Listing
April 2019
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Differences in concentration and source apportionment of PM between 2006 and 2015 over the PRD region in southern China.

Sci Total Environ 2019 Apr 4;673:708-718. Epub 2019 Apr 4.

Division of Environment and Sustainability, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China; Institute for the Environment, Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China; Department of Civil and Environmental Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong, China.

During China's 11th Five Year Plan (FYP) and 12th FYP (2006-2015), a series of air pollution control measures was implemented in the Pearl River Delta (PRD) region. Therefore, it is vital to determine how the concentration and sources of fine particulate matter (PM) in this region changed between 2006 and 2015. In this work, using 2006 and 2015 emission inventories, the concentration and source apportionment of PM were simulated using the Weather Research and Forecast - Comprehensive Air Quality Model with Extensions (WRF-CAMx) for January, April, July and October in the PRD region. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.452DOI Listing

Bioaccessibility estimates by gastric SBRC method to determine relationships to bioavailability of nickel in ultramafic soils.

Sci Total Environ 2019 Apr 6;673:685-693. Epub 2019 Apr 6.

School of Environmental Sciences, University of Guelph, Guelph, ON, Canada.

Frameworks for human health risk assessment often include the opportunity to correct the estimate of exposure for bioavailability, which could be predicted from bioaccessibility. Lead and As are the only metallic elements for which bioavailability and bioaccessibility have been correlated across a spectrum of mineralogy and particle types. The objective of the present study is to correlate in vivo bioavailability with ex vivo bioaccessibility for elevated Ni in soils of ultramafic origin and explore attribution of any variation in this correlation to mineralogical characterization of the Ni. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.059DOI Listing

Dopamine receptor D (DRD) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

Neuroimage Clin 2019 Apr 10;23:101822. Epub 2019 Apr 10.

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.

Objective: We aimed to understand the impact of dopamine receptor D (DRD) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRDdampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Given that DRD is concentrated in anterior regions of the limbic and cortical forebrain we anticipated genotype effects in patients with a more rostral pattern of neurodegeneration. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101822DOI Listing

Prevalence of adverse childhood experiences (ACEs) among US children.

Child Abuse Negl 2019 Apr 16;92:209-218. Epub 2019 Apr 16.

University of South Carolina College of Nursing, Columbia, South Carolina, United States.

Objective: The purpose of this study was to estimate the prevalence of adverse childhood experiences (ACEs) among children in the United States and to examine the relationship between child and family characteristics and the likelihood of reported exposure to ACEs.

Methods: Data were drawn from the nationally representative 2016 National Survey of Children's Health (NSCH). Parent-reported child ACE exposure was measured using counts of those reporting zero ACEs, one to three ACEs, and four or more ACEs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452134193013
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http://dx.doi.org/10.1016/j.chiabu.2019.04.010DOI Listing
April 2019
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Phenotypic variations alter the ecological impact of invasive alien species: Lessons from Parthenium hysterophorus.

J Environ Manage 2019 Apr 16;241:187-197. Epub 2019 Apr 16.

Department of Botany, Panjab University, Chandigarh, 160 014, India; Central University of Punjab, Mansa Road, Bathinda, 151 001, India.

Invasive plant species constantly adjust their behavior with ecological shifts by virtue of phenotypic plasticity and/or local adaptations. Changes in the phenotype of an invasive species may also trigger variations in its community level impacts, which is an acceptable, yet unexplored aspect of invasion biology. Our study attempts to fill important knowledge gaps on the basic behavior and ecological interactions of invasive species. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.129DOI Listing

Cross-cultural examination of college marijuana culture in five countries: Measurement invariance of the Perceived Importance of Marijuana to the College Experience Scale.

Addict Behav 2019 Apr 4;96:11-17. Epub 2019 Apr 4.

Center on Alcoholism, Substance Abuse, and Addictions, University of New Mexico, United States of America.

Marijuana internalized norms, measured by the Perceived Importance of Marijuana to the College Experience Scale (PIMCES; 8 items), has been found to be distinct from marijuana descriptive/injunctive norms and to be a unique robust predictor of marijuana-related outcomes among college students, yet the role of these beliefs has not been studied outside the U.S. Using confirmatory factor analysis, the present work examined the level of measurement invariance (i. Read More

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http://dx.doi.org/10.1016/j.addbeh.2019.04.004DOI Listing

Psychological Distress among Adolescents in Laos, Mongolia, Nepal, and Sri Lanka.

Asian Nurs Res (Korean Soc Nurs Sci) 2019 Apr 16. Epub 2019 Apr 16.

Hanyang University, College of Medicine, Department of Preventive Medicine; Hanyang University, Institute for Health and Society, Seoul, Republic of Korea.

Purpose: The purpose of this study was to explore psychological distress and examine the relationship between this distress and individual, family, and school factors among adolescents in four low- and middle-income countries (LAMICs) in Asia (i.e., Laos, Mongolia, Nepal, and Sri Lanka). Read More

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http://dx.doi.org/10.1016/j.anr.2019.04.001DOI Listing

Allogeneic stem cell transplantation for acute lymphoblastic leukemia in adolescents and young adults.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan; Department of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan.

Hematologic stem cell transplantation (HSCT) is the most potent consolidation therapy for high-risk acute lymphoblastic leukemia (ALL), but their outcomes and complications in adolescent and young adult (AYA) patients are still unclear. We compared outcomes after HSCT for ALL among children (1 to 9 years old, n = 607), adolescents (10 to 19 years old, n= 783) and young adults (20 to 29 years old, n = 603), based on nationwide registry data in Japan. The overall survival rate among AYA patients was worse than that of children; survival rate at 5 years among AYA patients was 64% (95% confidence intervals [CI], 60% to 68%). Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.014DOI Listing

Mother-infant interactions with firstborns and secondborns: A within-family study of European Americans.

Infant Behav Dev 2019 Apr 16;55:100-111. Epub 2019 Apr 16.

Institute for Fiscal Studies, London, UK.

Given the large numbers of families with more than one child, understanding similarities and differences in siblings' behaviors and in parents' interactions with their sibling infants is an important goal for advancing more representative developmental science. This study employed a within-family design to examine mean-level consistency and individual-order agreement in 5-month-old sibling behaviors and maternal parenting practices with their firstborns and secondborns (ns = 61 mothers and 122 infants). Each infant was seen independently with mother. Read More

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http://dx.doi.org/10.1016/j.infbeh.2019.03.009DOI Listing

A systematic review of the word sentence association paradigm (WSAP).

J Behav Ther Exp Psychiatry 2019 Apr 11;64:133-148. Epub 2019 Apr 11.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, United States; McLean Hospital/Harvard Medical School, United States. Electronic address:

Background And Objectives: The Word Sentence Association Paradigm (WSAP) was originally designed to assess and modify interpretive biases (IB) in socially anxious individuals. Researchers have since modified the WSAP for use across various populations. Despite its widespread use, no studies have systematically reviewed the WSAP to determine its validity and reliability. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00057916183017
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http://dx.doi.org/10.1016/j.jbtep.2019.04.003DOI Listing
April 2019
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SMP domain proteins in membrane lipid dynamics.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Lee Kong Chian School of Medicine, Nanyang Technological University, 308232, Singapore; Institute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan. Electronic address:

Synaptotagmin-like mitochondrial-lipid-binding (SMP) domain proteins are evolutionarily conserved family of proteins in eukaryotes that localize between the endoplasmic reticulum (ER) and either plasma membrane (PM) or other organelles. They are involved in tethering of these membrane contact sites through interaction with other proteins and membrane lipids. Recent structural and biochemical studies have demonstrated that SMP domain proteins transport a wide variety of lipid species by the ability of the SMP domain to harbor lipids through its unique hydrophobic cavity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13881981193005
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http://dx.doi.org/10.1016/j.bbalip.2019.04.007DOI Listing
April 2019
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Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: Phylogenetic characteristics of circulating Indian dengue viruses (DENV) were analysed using partial pre-membrane (PrM) and envelope (E) sequences. An immunodominant region was analysed for mutations and alignment with common DENV PCR primers and probes was determined.

Methods: Published Indian PrM and E DENV sequences were analysed with hitherto unpublished PrM sequences from this study site. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.010DOI Listing

Frailty biomarkers in humans and rodents: current approaches and future advances.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA; Department of Pharmacology, The University of New South Wales, Sydney, Australia. Electronic address:

Even though they would have great benefit across research and clinical fields, currently there are no accepted biomarkers of frailty. Cross-sectional studies in humans have identified promising candidates including inflammatory markers such as IL-6, immune markers such as WBC count, clinical markers such as albumin, endocrine markers such as vitamin D, oxidative stress markers such as isoprostanes, proteins such as BDNF and epigenetic markers such as DNA methylation, but there are limitations to the current state of the research. Future approaches to the identification of frailty biomarkers should include longitudinal studies, studies using animal models of frailty, studies incorporating novel biomarkers combined into composite panels, and studies investigating sex differences and potential overlap between markers of biological age and frailty. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374193003
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http://dx.doi.org/10.1016/j.mad.2019.03.007DOI Listing
April 2019
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(-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury.

Life Sci 2019 Apr 16. Epub 2019 Apr 16.

Faculty of Dentistry, University of Toronto, Canada; Deparment of Physiology, University of Toronto, Canada.

Neuropathic orofacial pain conditions represent a challenge to diagnose and treat. Natural substances are promising therapeutic options for the control of pain.

Aims: This study aimed to examine whether (-)-α-bisabolol (BISA), a natural terpene, can attenuate nociceptive behaviour and central sensitisation in a rodent model of trigeminal neuropathic pain. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.04.032DOI Listing

CUE-ALCOHOL associative learning in FEMALE RATS.

Alcohol 2019 Apr 16. Epub 2019 Apr 16.

The University of Texas at Austin; Institute for Neuroscience; Department of Psychology. Electronic address:

The ability of environmental cues to trigger alcohol seeking behaviors is believed to facilitate problematic alcohol use. We previously showed that the development of this cue-evoked alcohol approach reflects cue-alcohol learning and memory in the adult male rat; however, we do not know whether the same is true for similarly aged female rats. Consequently, adult Long-Evans female rats were allowed to drink unsweetened alcohol in the homecage (MWF 24 hr two-bottle choice, 5 weeks) and subsequently split into two experimental groups: paired and unpaired. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07418329193001
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http://dx.doi.org/10.1016/j.alcohol.2019.03.003DOI Listing
April 2019
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An electrophysiological investigation of orthographic spatial integration in reading.

Neuropsychologia 2019 Apr 16. Epub 2019 Apr 16.

Laboratoire de Psychologie Cognitive, Aix-Marseille University & CNRS, France.

During reading, word recognition speed is influenced by the amount of orthographic overlap with surrounding words. The nature of this phenomenon is not understood: some theories attribute it to low-level visual operations (i.e. Read More

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http://dx.doi.org/10.1016/j.neuropsychologia.2019.04.009DOI Listing

Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood.

Cell 2019 Apr;177(3):587-596.e9

Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants. Here we derive and validate a new polygenic predictor comprised of 2. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193029
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http://dx.doi.org/10.1016/j.cell.2019.03.028DOI Listing
April 2019
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Smartphones and Close Relationships: The Case for an Evolutionary Mismatch.

Perspect Psychol Sci 2019 Apr 19:1745691619826535. Epub 2019 Apr 19.

2 Department of Psychology, Wayne State University.

This article introduces and outlines the case for an evolutionary mismatch between smartphones and the social behaviors that help form and maintain close social relationships. As psychological adaptations that enhance human survival and inclusive fitness, self-disclosure and responsiveness evolved in the context of small kin networks to facilitate social bonds, promote trust, and enhance cooperation. These adaptations are central to the development of attachment bonds, and attachment theory is a middle-level evolutionary theory that provides a robust account of the ways human bonding provides for reproductive and inclusive fitness. Read More

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http://dx.doi.org/10.1177/1745691619826535DOI Listing

Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Daily eudaimonic well-being as a predictor of daily performance: A dynamic lens.

PLoS One 2019 19;14(4):e0215564. Epub 2019 Apr 19.

University of Valencia, IDOCAL, Valencia, Spain.

Sustaining employees' well-being and high performance at work is a challenge for organizations in today's highly competitive environment. This study examines the dynamic reciprocal relationship between the variability in office workers' eudaimonic well-being (i.e. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215564PLOS
April 2019
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Patterns of fish utilisation in a tropical Indo-Pacific mangrove-coral seascape, New Caledonia.

PLoS One 2019 19;14(4):e0207168. Epub 2019 Apr 19.

College of Science and Engineering, James Cook University, Townsville, Queensland, Australia.

Mangrove forests are important habitats for fish. However, their utilisation by fish, and the specific values they confer, are still not fully understood. This study describes how fish use mangrove forests in an Indo-Pacific mangrove-coral reef seascape. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207168PLOS
April 2019
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Evaluating and using existing models to map probable suitable habitat for rare plants to inform management of multiple-use public lands in the California desert.

PLoS One 2019 19;14(4):e0214099. Epub 2019 Apr 19.

California State Office, Bureau of Land Management, Sacramento, California, United States of America.

Multiple-use public lands require balancing diverse resource uses and values across landscapes. In the California desert, there is strong interest in renewable energy development and important conservation concerns. The Bureau of Land Management recently completed a land-use plan for the area that provides protection for modeled suitable habitat for multiple rare plants. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214099PLOS

A landscape-scale assessment of tropical mammals reveals the effects of habitat and anthropogenic disturbance on community occupancy.

PLoS One 2019 19;14(4):e0215682. Epub 2019 Apr 19.

Tropical Biodiversity Section, MUSE-Museo delle Scienze, Trento, Italy.

With biodiversity facing unparalleled threats from anthropogenic disturbance, knowledge on the occurrences of species and communities provides for an effective and fast approach to assess their status and vulnerability. Disturbance is most prominent at the landscape-level, for example through habitat loss from large-scale resource extraction or agriculture. However, addressing species responses to habitat changes at the landscape-scale can be difficult and cost-ineffective, hence studies are mostly conducted at single areas or habitat patches. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215682PLOS

A critique of general allometry-inspired models for estimating forest carbon density from airborne LiDAR.

PLoS One 2019 19;14(4):e0215238. Epub 2019 Apr 19.

Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom.

There is currently much interest in developing general approaches for mapping forest aboveground carbon density using structural information contained in airborne LiDAR data. The most widely utilized model in tropical forests assumes that aboveground carbon density is a compound power function of top of canopy height (a metric easily derived from LiDAR), basal area and wood density. Here we derive the model in terms of the geometry of individual tree crowns within forest stands, showing how scaling exponents in the aboveground carbon density model arise from the height-diameter (H-D) and projected crown area-diameter (C-D) allometries of individual trees. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215238PLOS

Discovery and characterization of variance QTLs in human induced pluripotent stem cells.

PLoS Genet 2019 Apr 19;15(4):e1008045. Epub 2019 Apr 19.

Department of Human Genetics, University of Chicago, Chicago, Illinois, United States of America.

Quantification of gene expression levels at the single cell level has revealed that gene expression can vary substantially even across a population of homogeneous cells. However, it is currently unclear what genomic features control variation in gene expression levels, and whether common genetic variants may impact gene expression variation. Here, we take a genome-wide approach to identify expression variance quantitative trait loci (vQTLs). Read More

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http://dx.plos.org/10.1371/journal.pgen.1008045
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http://dx.doi.org/10.1371/journal.pgen.1008045DOI Listing
April 2019
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Epigenetic regulator G9a provides glucose as a sweet key to stress resistance.

PLoS Biol 2019 Apr 19;17(4):e3000236. Epub 2019 Apr 19.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.

The ability to adapt to acute and chronic stress is important for organisms to thrive in evolutionary niches and for cells to survive in adverse conditions. The regulatory networks that control stress responses are evolutionarily conserved, and many factors that selectively activate stress responses have been identified. Less well understood are mechanisms that guard against unnecessary induction of cytoprotective factors and that connect stress responses with cellular metabolism to control energy expenditure during stress. Read More

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http://dx.doi.org/10.1371/journal.pbio.3000236DOI Listing

Inferring neural circuit structure from datasets of heterogeneous tuning curves.

PLoS Comput Biol 2019 Apr 19;15(4):e1006816. Epub 2019 Apr 19.

Institute of Neuroscience, University of Oregon, Eugene, Oregon, USA.

Tuning curves characterizing the response selectivities of biological neurons can exhibit large degrees of irregularity and diversity across neurons. Theoretical network models that feature heterogeneous cell populations or partially random connectivity also give rise to diverse tuning curves. Empirical tuning curve distributions can thus be utilized to make model-based inferences about the statistics of single-cell parameters and network connectivity. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006816DOI Listing

Gene Delivery Using Lipoplexes and Polyplexes: Principles, Limitations and Solutions.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):29-36

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Gene therapy has attracted considerable attention for the treatment of genetic and acquired diseases. Successful gene therapy occurs when the therapeutic genes penetrate targeted cells and become available to the intracellular active site. Currently, a promising approach in gene delivery is the use of nonviral gene delivery vectors that lack immunogenicity but have low toxicity and potential tissue specificity. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025132DOI Listing
January 2019

Evaluation of Three Rapid Screening Tests for Detection of Hepatitis C Antibodies on Mass Scale.

Crit Rev Eukaryot Gene Expr 2019 ;29(1):25-28

Department of Biotechnology, International Islamic University, Islamabad, Pakistan.

Hepatitis C virus (HCV) is a leading health problem across the globe. Only 20% of HCV positive individuals know their positive disease status. Effective HCV screening tests are required to screen both general and high-risk populations and identify the silent cases of HCV. Read More

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http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2018025062DOI Listing
January 2019
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Arrdc2 and Arrdc3 Elicit Divergent Changes in Gene Expression in Skeletal Muscle following Anabolic and Catabolic Stimuli.

Physiol Genomics 2019 Apr 19. Epub 2019 Apr 19.

Rancho BioSciences, United States.

Skeletal muscle is a highly plastic organ regulating various processes in the body. As such, loss of skeletal muscle underlies the increased morbidity and mortality risk that is associated with numerous conditions. However, no therapies are available to combat the loss of muscle mass during atrophic conditions, which is due in part to the incomplete understanding of the molecular networks altered by anabolic and catabolic stimuli. Read More

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https://www.physiology.org/doi/10.1152/physiolgenomics.00007
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http://dx.doi.org/10.1152/physiolgenomics.00007.2019DOI Listing
April 2019
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The Relative Importance of Personality, Financial Satisfaction, and Autonomy for Different Subjective Well-Being Facets.

J Psychol 2019 Apr 19:1-21. Epub 2019 Apr 19.

a Singapore University of Social Sciences.

Using a nationally representative sample (N = 507) from Singapore, this study examined whether personality, financial satisfaction, and autonomy were important to subjective well-being (SWB), and how the importance of these predictors varied across different SWB facets-life satisfaction, happiness, positive feelings, and negative feelings. The findings indicated that neuroticism, financial satisfaction, and autonomy, were important predictors of happiness. Personality was most important for affective well-being (i. Read More

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http://dx.doi.org/10.1080/00223980.2019.1598928DOI Listing

Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial.

AJOB Empir Bioeth 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Population Health Sciences , Duke University School of Medicine , Durham , North Carolina , USA.

Background: Some HIV prevention research participants may hold a "preventive misconception" (PM), an overestimate of the probability or level of personal protection afforded by trial participation. However, these reports typically rely upon small, retrospective qualitative assessments that did not use a standardized approach.

Methods: We administered a measure of PM called PREMIS, during Microbicide Trials Network 020-A Study to Prevent Infection with a Ring for Extended Use, a large, multicenter, placebo-controlled, phase III trial evaluating the safety and efficacy of a dapivirine vaginal ring among women at risk for HIV infection in Malawi, South Africa, Uganda, and Zimbabwe. Read More

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https://www.tandfonline.com/doi/full/10.1080/23294515.2019.1
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http://dx.doi.org/10.1080/23294515.2019.1593257DOI Listing
April 2019
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Higher Nest Predation Favors Rapid Fledging at the Cost of Plumage Quality in Nestling Birds.

Am Nat 2019 May 27;193(5):717-724. Epub 2019 Mar 27.

High predation risk can favor rapid offspring development at the expense of offspring quality. Impacts of rapid development on phenotypic quality should be most readily expressed in traits that minimize fitness costs. We hypothesize that ephemeral traits that are replaced or repaired after a short period of life might express trade-offs in quality as a result of rapid development more strongly than traits used throughout life. Read More

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http://dx.doi.org/10.1086/702856DOI Listing

Predicting the Thermal and Allometric Dependencies of Disease Transmission via the Metabolic Theory of Ecology.

Am Nat 2019 May 4;193(5):661-676. Epub 2019 Apr 4.

The metabolic theory of ecology (MTE) provides a general framework of allometric and thermal dependence that may be useful for predicting how climate change will affect disease spread. Using and a microsporidian gut parasite, we conducted two experiments across a wide thermal range and fitted transmission models that utilize MTE submodels for transmission parameters. We decomposed transmission into contact rate and probability of infection and further decomposed probability of infection into a product of gut residence time (GRT) and per-parasite infection rate of gut cells. Read More

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https://www.journals.uchicago.edu/doi/10.1086/702846
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May 2019
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Condition-Dependent Begging Elicits Increased Parental Investment in a Wild Bird Population.

Am Nat 2019 May 14;193(5):725-737. Epub 2019 Mar 14.

The coevolution of parental supply and offspring demand has long been thought to involve offspring need driving begging and parental care, leaving other hypotheses underexplored. In a population of wild birds, we experimentally tested whether begging serves as a negatively condition-dependent signal of need or a positively condition-dependent signal of quality. Across multiple years, we supplemented nestling house wrens with food shortly after hatching and simultaneously manipulated corticosterone levels to simulate the hunger-induced increase in glucocorticoids thought to mediate begging. Read More

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https://www.journals.uchicago.edu/doi/10.1086/702848
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May 2019
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Upscaling Microclimatic Conditions into Body Temperature Distributions of Ectotherms.

Am Nat 2019 May 20;193(5):677-687. Epub 2019 Mar 20.

Realistic projections of the biological impacts of climate change require predicting fitness responses to variations in environmental conditions. For ectotherms, this challenge requires methods to scale-up microclimatic information into actual body temperatures, , while dealing with uncertainty regarding individual behaviors and physiological constraints. Here, we propose an information-theoretical model to derive microhabitat selection and distributions of ectotherm populations from microclimatic data. Read More

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https://www.journals.uchicago.edu/doi/10.1086/702717
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http://dx.doi.org/10.1086/702717DOI Listing
May 2019
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Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy.

JCO Clin Cancer Inform 2019 Apr(3):1-9

1 University of Texas MD Anderson Cancer Center, Houston, TX.

Purpose: Nearly 40% of patients with breast cancer discontinue their adjuvant oral endocrine treatment (ET). We measured discontinuation rates of ET at a comprehensive cancer center. We then used an iterative approach to model patterns of determinants associated with discontinuation of ET. Read More

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https://ascopubs.org/doi/10.1200/CCI.18.00091
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http://dx.doi.org/10.1200/CCI.18.00091DOI Listing
April 2019
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The benefits of an animal-assisted intervention service to patients and staff at a children's hospital.

Authors:
Lyndsey S Uglow

Br J Nurs 2019 Apr;28(8):509-515

Lead Therapy Dog Handler, Southampton Children's Hospital, and Animal Assisted Intervention Advisor to the Royal College of Nursing Pets in Health Protocol.

An online survey of parents and staff was conducted to assess the effect of an animal-assisted intervention (AAI) service at a UK children's university teaching hospital. Three volunteer handlers with five golden retriever dogs provided AAIs across all eight paediatric wards including day, medical, surgical, oncology and intensive care. Interventions ranged from 'meet and greet' to assisting nursing care, physiotherapy and occupational therapy, as well as providing distraction during blood taking and other tests including radiology examinations. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.509DOI Listing

Differences in immunogenicity associated with non-product related variability: insights from two pharmacokinetic studies using GP2017, an adalimumab biosimilar.

Expert Opin Biol Ther 2019 Apr 19:1-8. Epub 2019 Apr 19.

a Global Clinical Development, Biopharmaceuticals , Hexal AG (A Sandoz Company) , Holzkirchen , Germany.

Introduction: Antidrug antibody (ADA) development is known to occur with adalimumab treatment and impacts adalimumab exposure. Here, we compare the impact of immunogenicity on pharmacokinetics (PK) across two randomized PK studies of GP2017, an approved biosimilar adalimumab, in healthy subjects.

Methods: Healthy male subjects (N= 107 in study GP17-104; N= 90 in study GP17-103) received a single 40 mg subcutaneous injection of the same GP2017 drug product batch. Read More

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http://dx.doi.org/10.1080/14712598.2019.1603959DOI Listing

Small Molecule Potentiation of Gram-positive Selective Antibiotics Against Acinetobacter baumannii.

ACS Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a variety of approaches to identifying effective new therapeutic strategies. One approach is the identification of small molecule adjuvants that potentiate the activity of antibiotics of demonstrated utility, whose efficacy is abated by resistance, both acquired and intrinsic. Read More

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http://pubs.acs.org/doi/10.1021/acsinfecdis.9b00067
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http://dx.doi.org/10.1021/acsinfecdis.9b00067DOI Listing
April 2019
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Assessing for Fetal Alcohol Spectrum Disorder.

J Popul Ther Clin Pharmacol 2019 Jan 23;26(1):e39-e55. Epub 2019 Jan 23.

Canada FASD Research Network.

Background The recommended "gold standard" for Fetal Alcohol Spectrum Disorder (FASD) assessment involves a multidisciplinary diagnostic team and comprehensive battery of neuropsychological tests to evaluate functioning across 10 brain domains. The current Canadian Guideline for diagnosis of FASD outlines a list of test measures for assessment; however, very little research exists to explore which specific tools are being used in clinical practice. Objectives The purpose of the current study was to gain a better understanding of the testing measures used by FASD clinicians in Alberta, Canada. Read More

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http://jptcp.com/index.php/jptcp/article/view/54
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http://dx.doi.org/10.22374/1710-6222.26.1.4DOI Listing
January 2019
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