78 results match your criteria Acropustulosis of Infancy


Enhancing patient research partner engagement: Research in psoriatic arthritis.

Authors:
Niti Goel

Best Pract Res Clin Rheumatol 2021 Apr 26:101685. Epub 2021 Apr 26.

Duke University School of Medicine, Durham, NC, 27705, USA. Electronic address:

The perspective from individuals with psoriatic arthritis (PsA) can be beneficial to PsA research, increasing the likelihood that the results are meaningful and relevant to PsA patients. While there has been an advancement of patient research partner (PRP) involvement in PsA research over time, the effort is still in its infancy. Measures to ensure PRP engagement (PRPE) occurs and its impact evaluated need to be implemented routinely to increase PRPE in PsA research. Read More

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Transforming clinical trials in rheumatology: towards patient-centric precision medicine.

Nat Rev Rheumatol 2020 10 4;16(10):590-599. Epub 2020 Sep 4.

Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.

Despite the success of targeted therapies in the treatment of inflammatory arthritides, the lack of predictive biomarkers drives a 'trial and error' approach to treatment allocation, leading to variable and/or unsatisfactory responses. In-depth characterization of the synovial tissue in rheumatoid arthritis, as well as psoriatic arthritis and spondyloarthritis, is bringing new insights into the diverse cellular and molecular features of these diseases and their potential links with different clinical and treatment-response phenotypes. Such progress raises the tantalizing prospect of improving response rates by matching the use of specific agents to the cognate target pathways that might drive particular disease subtypes in specific patient groups. Read More

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October 2020

Granuloma Annulare, a Possible Paradoxical Reaction of the Adalimumab Treatment in a Severe Case of Psoriasis Vulgaris.

Curr Health Sci J 2020 Apr-Jun;46(2):203-206. Epub 2020 Jun 30.

University of Medicine and Pharmacy of Craiova, Romania.

Granuloma annulare (GA) is a benign chronic inflammatory dermatosis, self-limited, slightly pruritic or asymptomatic in the majority of the cases, with specific clinically and histologically features, that occurs in all age groups, but it is rare in infancy. GA is associated to five clinical variants: localized, generalized, perforating, subcutaneous and arcuate dermal erythema. The etiology of GA is usually unknown, but in 60-75% of the cases it is associated with metabolic disorders (diabetes mellitus, dyslipidemia), thyroid disorders, neoplasms, infections or drug induced. Read More

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Psoriasis Among Adolescents in Kuwait and the Role of Siblings, Breastfeeding, and Household Cat and Secondhand Smoke Exposure: A Cross-Sectional Study.

Dermatol Ther (Heidelb) 2020 Oct 25;10(5):1137-1153. Epub 2020 Aug 25.

Department of Internal Medicine, Mubarak Al-Kabeer Hospital, Ministry of Health, Kuwait City, Kuwait.

Introduction: Globally, the epidemiology of psoriasis is poorly understood, and most countries lack essential epidemiologic data regarding disease burden and its determinants. This study sought to estimate the prevalence of psoriasis among adolescents in Kuwait and assess its association with different risk factors, including obesity, sibship size, breastfeeding, and exposure to household secondhand smoke (SHS) and pets.

Methods: Schoolchildren aged 11-14 years (n = 3864) were enrolled in a cross-sectional study. Read More

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October 2020

Clinical characteristics including cardiovascular and metabolic risk factors in adolescents with psoriasis.

J Eur Acad Dermatol Venereol 2020 Jul 19;34(7):1516-1523. Epub 2020 Feb 19.

Copenhagen Research Group for Inflammatory Skin (CORGIS), Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Background: Clinical studies on psoriasis in adolescents have mainly been performed in patients with severe psoriasis. Population-based studies of clinical characteristics and risk factors for later cardiovascular and metabolic disease in children and adolescents are lacking.

Objectives: To examine the clinical characteristics of adolescents with psoriasis nested in a general population cohort. Read More

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Prenatal, infantile, and childhood tobacco exposure and risk of pediatric psoriasis in the Danish National Birth Cohort offspring.

J Am Acad Dermatol 2020 Dec 20;83(6):1625-1632. Epub 2020 Jan 20.

Department of Dermatology and Allergy, Herlev and Gentofte Hospital, Copenhagen, Denmark.

Background: Tobacco smoking is implicated in psoriasis among adults.

Objective: To determine whether prenatal, infantile, and childhood tobacco exposure increase risk of pediatric psoriasis.

Methods: Data from Danish National Birth Cohort participants were collected at approximately gestational week 12 and when the children were approximately 6 months and 11 years of age. Read More

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December 2020

Inflammatory linear verrucous epidermal nevus responsive to 308-nm excimer laser treatment.

Cutis 2018 Aug;102(2):111-114

Advanced Dermatology Associates LTD; Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare cutaneous disease that presents as linear psoriasiform plaques with associated prominent pruritus. The lesions commonly pre-sent on the legs with onset during childhood. Inflammatory linear verrucous epidermal nevus typically is refractory to treatment. Read More

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Spondyloarthritis: new insights into clinical aspects, translational immunology and therapeutics.

Curr Opin Rheumatol 2018 09;30(5):526-532

Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds, NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, UK.

Purpose Of Review: The spondyloarthopathies (SpA), which encompass related diseases that were originally viewed as autoimmune, are now known to have a strong innate immune or autoinflammatory initiation phase characterized by disease localization to tissue-specific sites based on the nuances and microanatomy and immunology of those sites. This review covers recent translational advances in the field of SpA.

Recent Findings: Imaging studies in SpA continue to add support for the pivotal role of enthesitis in disease initiation and expression. Read More

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September 2018

Granulocyte and monocyte apheresis can control juvenile generalized pustular psoriasis with mutation of IL36RN.

Br J Dermatol 2017 12 1;177(6):1732-1736. Epub 2017 Oct 1.

Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Read More

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December 2017

Perianal Lesions in Children: An Updated Review.

Am J Clin Dermatol 2017 Jun;18(3):343-354

Department of Dermatology, State University of New York Downstate Medical Center, 10 West, 800 Poly Place, Brooklyn, NY, 11203, USA.

Perianal lesions in children are common reasons for dermatology clinic visits and a well-defined approach to diagnosis and management is helpful to the practicing clinician. In this article, we review and update various etiologies of perianal lesions in the pediatric population, including infectious, papulosquamous, vascular, and neoplastic. We provide a standard initial approach to diagnosis and updates on current management. Read More

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Th9 cells and IL-9 in autoimmune disorders: Pathogenesis and therapeutic potentials.

Hum Immunol 2017 Feb 28;78(2):120-128. Epub 2016 Dec 28.

Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China. Electronic address:

Naïve CD4 T cells are pleiotropically divided into various T helper (Th) cell subsets, according to their pivotal roles in the regulation of immune responses. The differentiation of Th9 cells, an interleukin (IL)-9 producing subset, can be impacted by specific environmental cues, co-stimulation with transforming growth factor β (TGF-β) and IL-4, and other regulatory factors. Although IL-9 has been recognized as a classical Th2-related cytokine, recent studies have indicated that IL-9-producing cells contribute to a group of autoimmune disorders including systemic lupus erythematosus (SLE), multiple sclerosis (MS), inflammatory bowel diseases (IBD), rheumatoid arthritis (RA) and psoriasis. Read More

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February 2017

Psoriasis in children.

Psoriasis (Auckl) 2016;6:121-129. Epub 2016 Oct 20.

Division of Dermatology and Cutaneous Sciences, Department of Medicine.

The clinical presentation, disease associations, and diverse treatment modalities in overcoming the challenges of managing pediatric psoriasis have been extensively summarized in this article. An extensive literature review revealed the differences in presentation of psoriasis during infancy, childhood, and adolescence. We also summarized the latest topical, systemic, and biological modalities in treating recalcitrant psoriasis. Read More

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October 2016

Napkin psoriasis.

Pediatr Int 2016 May 21;58(5):420-422. Epub 2016 Apr 21.

Ataturk Research and Training Hospital, Department of Pathology, Izmir, Turkey.

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PRINS, a primate-specific long non-coding RNA, plays a role in the keratinocyte stress response and psoriasis pathogenesis.

Pflugers Arch 2016 06 3;468(6):935-43. Epub 2016 Mar 3.

MTA-SZTE Dermatological Research Group, Szeged, Korányi fasor 6, 6720, Hungary.

In the last few years with the recent emergence of high-throughput technologies, thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome. However, assigning functional annotation and determining cellular contexts for these RNAs are still in its infancy. As information gained about lncRNA structure, interacting partners, and roles in human diseases may be helpful in the characterization of novel lncRNAs, we review our knowledge on a selected group of lncRNAs that were identified serendipitously years ago by large-scale gene expression methods used to study human diseases. Read More

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Microbiome: Paediatricians' perspective.

Indian J Med Res 2015 Nov;142(5):515-24

Department of Pediatrics, Postgraduate Institute of Medical Education & Research & Dr Ram Manohar Lohia Hospital, New Delhi, India.

Millions of microorganisms inhabit the human body and affect its homeostasis in multiple ways. Alterations in this microbial community have implications for the health and survival of the human hosts. It is believed that these microorganisms should be included as part of the human genome because of their influence on human physiology hence the term "microbiome" is commonly used to refer to these microbes along with their genetic make-up and their environmental interactions. Read More

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November 2015

Case report: Diaper dermatitis presenting as pustules.

J Drugs Dermatol 2014 Sep;13(9):1153-4

Diaper dermatitis is the most common dermatologic disorder of infancy. Its cause can often be determined clinically based on the clinical presentation. Primary diaper dermatitis is associated with irritants and spares the deep skin folds. Read More

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September 2014

Psoriasis and seborrheic dermatitis in infancy and childhood.

G Ital Dermatol Venereol 2014 Dec 15;149(6):683-91. Epub 2014 Oct 15.

Section of Dermatology, Department of Surgical Sciences, Parma Medical School, Parma, Italy -

Psoriasis is a common inflammatory dermatosis that may be seen in infants, children, and adolescents. The clinical presentation and course may be quite variable, and while patients with mild disease are often easily managed, those with recalcitrant or more severe disease often present a therapeutic dilemma given the number of therapies available and the relative lack of data on the efficacy and safety of use of these therapies in children. Diagnosis in children can be more difficult, but family history may be helpful. Read More

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December 2014

The role of sterol-C4-methyl oxidase in epidermal biology.

Biochim Biophys Acta 2014 Mar 18;1841(3):331-5. Epub 2013 Oct 18.

Department of Pediatrics, University of Pittsburgh School of Medicine, Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA USA.

Deficiency of sterol C4 methyl oxidase, encoded by the SC4MOL gene, has recently been described in four patients from three different families. All of the patients presented with microcephaly, congenital cataracts, and growth delay in infancy. The first patient has suffered since the age of six years from severe, diffuse, psoriasiform dermatitis, sparing only her palms. Read More

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Novel IL36RN mutation in a Japanese case of early onset generalized pustular psoriasis.

J Dermatol 2013 Sep 9;40(9):749-51. Epub 2013 Jul 9.

Department of Dermatology, Wakayama Medical University, Wakayama, Japan.

Generalized pustular psoriasis is a distinct type of psoriasis characterized by recurrent febrile attacks with disseminated subcorneal pustules on generalized skin rashes. Recently, homozygous and compound heterozygous mutations of the IL36RN gene, which encodes the anti-inflammatory cytokine interleukin (IL)-36 receptor antagonist, were identified in familial and sporadic cases of various ethnicities with generalized pustular psoriasis. Here we report a 39-year-old Japanese male patient who had suffered from repeated attacks of generalized pustular psoriasis since infancy with intervals of several years. Read More

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September 2013

Targeting the redox balance in inflammatory skin conditions.

Int J Mol Sci 2013 Apr 26;14(5):9126-67. Epub 2013 Apr 26.

Department of Orthodontics and Craniofacial Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.

Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling. However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage. Read More

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Netherton syndrome and its multifaceted defective protein LEKTI.

G Ital Dermatol Venereol 2013 Feb;148(1):37-51

Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.

Netherton syndrome (NS, OMIM 256500) is a rare autosomal recessive disorder manifesting with congenital ichthyosis, a specific hair shaft abnormality named trichorrhexis invaginata, and atopic manifestations. Because of severe complications frequently occurring in the neonatal period, NS prognosis can be poor in infancy. NS is due to loss-of-function mutations in the SPINK5 gene and to the consequent lack of expression of its encoded protein LEKTI in the skin and all stratified epithelial tissues. Read More

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February 2013

Acropustulosis of infancy.

Arch Dis Child Fetal Neonatal Ed 2013 Jul 18;98(4):F340. Epub 2012 Sep 18.

Department of Paediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65, Trieste, Italy.

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A comparative study of childhood psoriasis and atopic dermatitis and greater understanding of the overlapping condition, psoriasis-dermatitis.

Australas J Dermatol 2012 May;53(2):98-105

Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia. [email protected]

Background And Objectives: Psoriasis (Pso) in children may be confused clinically with atopic dermatitis (AD) and, indeed, the two conditions may co-exist. The aim of this study was to determine historical and clinical features that are different in paediatric Pso and AD and to describe children who have features of both: psoriasis-dermatitis overlap (PD).

Methods: Children with features of psoriasis or eczema, or both, who were referred to paediatric outpatients and/or private rooms were evaluated. Read More

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Methotrexate: a detailed review on drug delivery and clinical aspects.

Expert Opin Drug Deliv 2012 Feb;9(2):151-69

Banaras Hindu University, Institute of Technology, Department of Pharmaceutics, Varanasi, India.

Introduction: Uses of methotrexate (MTX) are well established for the treatment of various types of malignancy, psoriasis, rheumatological diseases and the medical termination of pregnancy. Formulation and targeting approaches for MTX with controlled release carriers, multiparticulate systems, prodrug and drug conjugates have been found to improve bioavailability, reduce adverse effects and maximize clinical efficacy, compared with conventional methods.

Areas Covered: This exhaustive literature survey on different electronic databases covers drug delivery and clinical trials on MTX. Read More

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February 2012

Rheumatoid arthritis in Cardinal Carlo de' Medici (1595-1666): a confirmed macroscopic, radiologic and molecular diagnosis.

Clin Exp Rheumatol 2012 Jan-Feb;30(1):12-22. Epub 2012 Mar 6.

Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy.

Objectives: The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. Read More

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Status of propranolol for treatment of infantile hemangioma and description of a randomized clinical trial.

Ann Otol Rhinol Laryngol 2011 Oct;120(10):686-95

The Feldman ENT Group, Chevy Chase, Maryland, USA.

Objectives: Our primary objective was to review the current use of propranolol for treatment of infantile hemangioma (IH), specifically regarding 1) the age at initiation of therapy, 2) the method of initiation, 3) the use of other adjuvant therapy, 4) the duration of therapy and relapse rate, 5) the adverse events, and 6) the outcome. Our secondary objective was to describe a randomized, controlled, single-blinded trial comparing propranolol to prednisolone for treatment of IH.

Methods: Ovid Medline and PubMed searches were completed for the MeSH keywords "propranolol" and "hemangioma. Read More

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October 2011

[Approaches to the dermatopathologic diagnosis of figurate lesions].

Actas Dermosifiliogr 2011 Jun 15;102(5):316-24. Epub 2011 Mar 15.

Departamento de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, España.

Both clinical and pathologic findings must be considered when diagnosing figurate skin lesions, which are often seen in routine practice. Although a skin biopsy may sometimes be diagnostic, more often the information provided is nonspecific. In an attempt to offer an approach to diagnosing these dermatoses, we have classified annular lesions according to the presence of lymphocytic, neutrophilic-eosinophilic, or granulomatous infiltrates, and infiltrates containing plasma cells. Read More

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Childhood pustular psoriasis: case report.

An Bras Dermatol 2010 Nov-Dec;85(6):899-902

Dermatology Service, Professor Edgar Santos University Hospital Complex, The Federal University of Bahia, Salvador, BA, Brazil.

Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Read More

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October 2011

Update on pediatric psoriasis, part 1: clinical features and demographics.

Cutis 2010 Sep;86(3):118-24

Pediatric and Adolescent Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA.

Pediatric psoriasis consists of infantile psoriasis, a self-limited disease of infancy; psoriasis with onset in childhood; and psoriasis with psoriatic arthritis. Approximately one-quarter to one-third of cases of psoriasis begin before 18 years of age. A variety of lesion types are seen in childhood, including plaque-type, guttate, nail-based, napkin, and erythrodermic disease. Read More

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September 2010

Pediatric psoriasis: an update.

Ther Clin Risk Manag 2009 2;5:849-56. Epub 2009 Nov 2.

Pediatric and Adolescent Dermatology, St. Luke's-Roosevelt Hospital Center, New York, NY, USA.

Pediatric psoriasis consists broadly of 3 age groups of psoriatic patients: infantile psoriasis, a self-limited disease of infancy, psoriasis with early onset, and pediatric psoriasis with psoriatic arthritis. About one-quarter of psoriasis cases begin before the age of 18 years. A variety of clinical psoriasis types are seen in childhood, including plaque-type, guttate, erythrodermic, napkin, and nail-based disease. Read More

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