70 results match your criteria Acropustulosis of Infancy
Br J Dermatol 2017 Dec 1;177(6):1732-1736. Epub 2017 Oct 1.
Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Patients with deficiency of interleukin-36 receptor antagonist (DITRA), due to mutation of IL36RN, exhibit psoriatic phenotypes, typically generalized pustular psoriasis (GPP). We report a paediatric patient with DITRA, whose cutaneous lesions varied from psoriasis vulgaris in infancy to annular pustular psoriasis with acute exacerbation to GPP at 13 years of age. Conventional systemic treatments for GPP, which include oral retinoids, ciclosporin and methotrexate, are controversial in paediatric cases, because of their adverse effects and uncertain long-term consequences. Read More
Am J Clin Dermatol 2017 Jun;18(3):343-354
Department of Dermatology, State University of New York Downstate Medical Center, 10 West, 800 Poly Place, Brooklyn, NY, 11203, USA.
Perianal lesions in children are common reasons for dermatology clinic visits and a well-defined approach to diagnosis and management is helpful to the practicing clinician. In this article, we review and update various etiologies of perianal lesions in the pediatric population, including infectious, papulosquamous, vascular, and neoplastic. We provide a standard initial approach to diagnosis and updates on current management. Read More
Hum Immunol 2017 Feb 28;78(2):120-128. Epub 2016 Dec 28.
Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China. Electronic address:
Naïve CD4 T cells are pleiotropically divided into various T helper (Th) cell subsets, according to their pivotal roles in the regulation of immune responses. The differentiation of Th9 cells, an interleukin (IL)-9 producing subset, can be impacted by specific environmental cues, co-stimulation with transforming growth factor β (TGF-β) and IL-4, and other regulatory factors. Although IL-9 has been recognized as a classical Th2-related cytokine, recent studies have indicated that IL-9-producing cells contribute to a group of autoimmune disorders including systemic lupus erythematosus (SLE), multiple sclerosis (MS), inflammatory bowel diseases (IBD), rheumatoid arthritis (RA) and psoriasis. Read More
Psoriasis (Auckl) 2016;6:121-129. Epub 2016 Oct 20.
Division of Dermatology and Cutaneous Sciences, Department of Medicine.
The clinical presentation, disease associations, and diverse treatment modalities in overcoming the challenges of managing pediatric psoriasis have been extensively summarized in this article. An extensive literature review revealed the differences in presentation of psoriasis during infancy, childhood, and adolescence. We also summarized the latest topical, systemic, and biological modalities in treating recalcitrant psoriasis. Read More
Pediatr Int 2016 May 21;58(5):420-422. Epub 2016 Apr 21.
Ataturk Research and Training Hospital, Department of Pathology, Izmir, Turkey.
Pflugers Arch 2016 06 3;468(6):935-43. Epub 2016 Mar 3.
MTA-SZTE Dermatological Research Group, Szeged, Korányi fasor 6, 6720, Hungary.
In the last few years with the recent emergence of high-throughput technologies, thousands of long non-coding RNAs (lncRNAs) have been identified in the human genome. However, assigning functional annotation and determining cellular contexts for these RNAs are still in its infancy. As information gained about lncRNA structure, interacting partners, and roles in human diseases may be helpful in the characterization of novel lncRNAs, we review our knowledge on a selected group of lncRNAs that were identified serendipitously years ago by large-scale gene expression methods used to study human diseases. Read More
Indian J Med Res 2015 Nov;142(5):515-24
Department of Pediatrics, Postgraduate Institute of Medical Education & Research & Dr Ram Manohar Lohia Hospital, New Delhi, India.
Millions of microorganisms inhabit the human body and affect its homeostasis in multiple ways. Alterations in this microbial community have implications for the health and survival of the human hosts. It is believed that these microorganisms should be included as part of the human genome because of their influence on human physiology hence the term "microbiome" is commonly used to refer to these microbes along with their genetic make-up and their environmental interactions. Read More
J Drugs Dermatol 2014 Sep;13(9):1153-4
Diaper dermatitis is the most common dermatologic disorder of infancy. Its cause can often be determined clinically based on the clinical presentation. Primary diaper dermatitis is associated with irritants and spares the deep skin folds. Read More
G Ital Dermatol Venereol 2014 Dec 15;149(6):683-91. Epub 2014 Oct 15.
Section of Dermatology, Department of Surgical Sciences, Parma Medical School, Parma, Italy -
Psoriasis is a common inflammatory dermatosis that may be seen in infants, children, and adolescents. The clinical presentation and course may be quite variable, and while patients with mild disease are often easily managed, those with recalcitrant or more severe disease often present a therapeutic dilemma given the number of therapies available and the relative lack of data on the efficacy and safety of use of these therapies in children. Diagnosis in children can be more difficult, but family history may be helpful. Read More
Biochim Biophys Acta 2014 Mar 18;1841(3):331-5. Epub 2013 Oct 18.
Department of Pediatrics, University of Pittsburgh School of Medicine, Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA USA.
Deficiency of sterol C4 methyl oxidase, encoded by the SC4MOL gene, has recently been described in four patients from three different families. All of the patients presented with microcephaly, congenital cataracts, and growth delay in infancy. The first patient has suffered since the age of six years from severe, diffuse, psoriasiform dermatitis, sparing only her palms. Read More
J Dermatol 2013 Sep 9;40(9):749-51. Epub 2013 Jul 9.
Department of Dermatology, Wakayama Medical University, Wakayama, Japan.
Generalized pustular psoriasis is a distinct type of psoriasis characterized by recurrent febrile attacks with disseminated subcorneal pustules on generalized skin rashes. Recently, homozygous and compound heterozygous mutations of the IL36RN gene, which encodes the anti-inflammatory cytokine interleukin (IL)-36 receptor antagonist, were identified in familial and sporadic cases of various ethnicities with generalized pustular psoriasis. Here we report a 39-year-old Japanese male patient who had suffered from repeated attacks of generalized pustular psoriasis since infancy with intervals of several years. Read More
Int J Mol Sci 2013 Apr 26;14(5):9126-67. Epub 2013 Apr 26.
Department of Orthodontics and Craniofacial Biology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Reactive oxygen species (ROS) can be both beneficial and deleterious. Under normal physiological conditions, ROS production is tightly regulated, and ROS participate in both pathogen defense and cellular signaling. However, insufficient ROS detoxification or ROS overproduction generates oxidative stress, resulting in cellular damage. Read More
G Ital Dermatol Venereol 2013 Feb;148(1):37-51
Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy.
Netherton syndrome (NS, OMIM 256500) is a rare autosomal recessive disorder manifesting with congenital ichthyosis, a specific hair shaft abnormality named trichorrhexis invaginata, and atopic manifestations. Because of severe complications frequently occurring in the neonatal period, NS prognosis can be poor in infancy. NS is due to loss-of-function mutations in the SPINK5 gene and to the consequent lack of expression of its encoded protein LEKTI in the skin and all stratified epithelial tissues. Read More
Arch Dis Child Fetal Neonatal Ed 2013 Jul 18;98(4):F340. Epub 2012 Sep 18.
Department of Paediatrics, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Via dell'Istria 65, Trieste, Italy.
Australas J Dermatol 2012 May;53(2):98-105
Department of Dermatology, Royal North Shore Hospital, Sydney, New South Wales, Australia. drshivamkapila@gmail
Background And Objectives: Psoriasis (Pso) in children may be confused clinically with atopic dermatitis (AD) and, indeed, the two conditions may co-exist. The aim of this study was to determine historical and clinical features that are different in paediatric Pso and AD and to describe children who have features of both: psoriasis-dermatitis overlap (PD).
Methods: Children with features of psoriasis or eczema, or both, who were referred to paediatric outpatients and/or private rooms were evaluated. Read More
Expert Opin Drug Deliv 2012 Feb;9(2):151-69
Banaras Hindu University, Institute of Technology, Department of Pharmaceutics, Varanasi, India.
Introduction: Uses of methotrexate (MTX) are well established for the treatment of various types of malignancy, psoriasis, rheumatological diseases and the medical termination of pregnancy. Formulation and targeting approaches for MTX with controlled release carriers, multiparticulate systems, prodrug and drug conjugates have been found to improve bioavailability, reduce adverse effects and maximize clinical efficacy, compared with conventional methods.
Areas Covered: This exhaustive literature survey on different electronic databases covers drug delivery and clinical trials on MTX. Read More
Clin Exp Rheumatol 2012 Jan-Feb;30(1):12-22. Epub 2012 Mar 6.
Department of Oncology, Transplants and Advanced Technologies in Medicine, Division of Paleopathology, History of Medicine and Bioethics, University of Pisa, Italy.
Objectives: The paleopathological study of the skeletal remains belonging to Cardinal Carlo de' Medici (1595-1666), son of Ferdinando I (1549-1609) and Cristina of Lorena (1565-1637), has been presented previously. A diagnosis of Klippel-Feil syndrome, tuberculosis and a polyarthopathy, interpreted as rheumatoid arthritis, was suggested. A revision of this case based on the analysis of the historical documents and of some radiological images of Carlo's bones has been proposed recently; according to the Authors, the Cardinal was affected by the 'Medici syndrome', a combined Psoriatic-DISH arthropathy. Read More
Ann Otol Rhinol Laryngol 2011 Oct;120(10):686-95
The Feldman ENT Group, Chevy Chase, Maryland, USA.
Objectives: Our primary objective was to review the current use of propranolol for treatment of infantile hemangioma (IH), specifically regarding 1) the age at initiation of therapy, 2) the method of initiation, 3) the use of other adjuvant therapy, 4) the duration of therapy and relapse rate, 5) the adverse events, and 6) the outcome. Our secondary objective was to describe a randomized, controlled, single-blinded trial comparing propranolol to prednisolone for treatment of IH.
Methods: Ovid Medline and PubMed searches were completed for the MeSH keywords "propranolol" and "hemangioma. Read More
Actas Dermosifiliogr 2011 Jun 15;102(5):316-24. Epub 2011 Mar 15.
Departamento de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, España.
Both clinical and pathologic findings must be considered when diagnosing figurate skin lesions, which are often seen in routine practice. Although a skin biopsy may sometimes be diagnostic, more often the information provided is nonspecific. In an attempt to offer an approach to diagnosing these dermatoses, we have classified annular lesions according to the presence of lymphocytic, neutrophilic-eosinophilic, or granulomatous infiltrates, and infiltrates containing plasma cells. Read More
An Bras Dermatol 2010 Nov-Dec;85(6):899-902
Dermatology Service, Professor Edgar Santos University Hospital Complex, The Federal University of Bahia, Salvador, BA, Brazil.
Generalized pustulous psoriasis is a rare type of psoriasis first described in 1910 by Von Zumbusch. This disease tends to have a more benign development in children when compared to its development in adults. However, in its serious form it may represent a risk to the patient's life. Read More
Cutis 2010 Sep;86(3):118-24
Pediatric and Adolescent Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA.
Pediatric psoriasis consists of infantile psoriasis, a self-limited disease of infancy; psoriasis with onset in childhood; and psoriasis with psoriatic arthritis. Approximately one-quarter to one-third of cases of psoriasis begin before 18 years of age. A variety of lesion types are seen in childhood, including plaque-type, guttate, nail-based, napkin, and erythrodermic disease. Read More
Ther Clin Risk Manag 2009 2;5:849-56. Epub 2009 Nov 2.
Pediatric and Adolescent Dermatology, St. Luke's-Roosevelt Hospital Center, New York, NY, USA.
Pediatric psoriasis consists broadly of 3 age groups of psoriatic patients: infantile psoriasis, a self-limited disease of infancy, psoriasis with early onset, and pediatric psoriasis with psoriatic arthritis. About one-quarter of psoriasis cases begin before the age of 18 years. A variety of clinical psoriasis types are seen in childhood, including plaque-type, guttate, erythrodermic, napkin, and nail-based disease. Read More
Pediatr Dermatol 2009 May-Jun;26(3):352-4
Department of Pediatrics, Section of Neonatology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Taiwan.
Generalized pustular psoriasis (GPP) is rare in childhood, especially in early infancy. At this young age, it is essential to make an accurate diagnosis as pustules could be the presentation of serious infectious diseases or unusual dermatologic diseases. We reported clinical manifestations, laboratory examinations, and histopathology findings in a 6-week-old girl with GPP. Read More
J Cutan Pathol 2010 Feb 13;37(2):249-55. Epub 2009 Jul 13.
Department of Pathology, Necker-Enfants Malades Hospital, APHP, Université René-Descartes, Paris V, France.
Background: Erythrodermas are often life-threatening conditions in infants. Determination of the underlying cause is crucial. Microscopic changes in adult erythroderma lack specificity. Read More
J Am Acad Dermatol 2009 Apr;60(4):679-83
Departments of Dermatology and Pediatrics at Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
We describe 6 patients who presented during infancy with erythematous papules or pustules localized to the neck and sometimes other intertriginous areas as well. Most of these infants were initially thought to have dermatitis or a bacterial or candidal infection. A biopsy specimen established the diagnosis of pustular psoriasis in 5 of the 6 cases. Read More
Dermatol Ther 2006 Mar-Apr;19(2):73-82
Oregon Health and Sciences University, Portland, 97239, USA.
Atopic is the most common of the dermatitides seen in infancy and childhood, but there are numerous other diseases that can mimic the skin findings. These include seborrheic dermatitis, immunodeficiency, and psoriasis in infancy; scabies, tinea corporis infection, perioral, nummular, contact, and molluscum dermatitis in childhood. It is sometimes extremely difficult to differentiate between ichthyosis and AD, and it is also important to differentiate AD from erythrodermic conditions including acrodermatitis enteropathica, biotin deficiency, and Netherton syndrome. Read More
Zhonghua Er Ke Za Zhi 2003 Apr;41(4):249-51
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
Objective: To investigate the clinical and neurodevelopmental profiles of patients with biotinidase deficiency and to determine the efficacy of current therapy with respect to outcome.
Methods: Six patients aged from 3 months to 14 years with biotinidase deficiency were confirmed by urinary organic acid analysis with gas chromatography/mass spectrometry (GC/MS) and biotinidase assay on dried blood spots. Biotin was supplemented individually (10-40 mg/d). Read More
Clin Exp Dermatol 2002 Oct;27(7):585-90
The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK.
Cytokines are intercellular messengers that have an important role in the development and maintenance of cutaneous inflammation. The primacy of cytokines in eliciting cutaneous immune responses makes them a highly attractive target for new biological response modifiers. Targeting of cytokines is still in its infancy for therapy of skin disease. Read More
Am J Clin Dermatol 2002 ;3(6):389-400
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
The differential diagnosis for pustular skin disorders is extensive. The distribution of the lesions and the age of the patient are characteristics that may provide strong clues to the etiology of cutaneous pustular eruptions. In adults, generalized pustular dermatoses include pustular psoriasis, Reiter's disease and subcorneal pustular dermatosis. Read More
Cutis 2001 Nov;68(5):341-4
Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA.
Psoriasis in infancy is often more therapeutically challenging than atopic and seborrheic dermatitis. The generalized nature of psoriasis and the intensity of inflammation often reduce the efficacy of topical corticosteroids. Furthermore, involvement of intertriginous skin and the presence of scalp disease limit the potency of the topical steroids that can be prescribed. Read More
Pediatr Dermatol 2001 May-Jun;18(3):188-98
Department of Clinical Epidemiology, Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia.
Our aim was to describe the types of psoriasis seen in a large series of patients presenting to a tertiary referral pediatric dermatology department using a classification system combining conventional terminology and additional categories based on the site and characteristics of the rash. A total of 1262 patients seen consecutively in the dermatology department of the Royal Alexandra Hospital for Children, Sydney, Australia, between 1981 and 1995 are described and classified according to the pattern of psoriasis at the time of presentation. Additional information recorded included family history, facial involvement, and history of a psoriatic type of diaper rash in infancy. Read More
Clin Exp Dermatol 2001 May;26(3):251-5
Department of Dermatology, King's College Hospital, London, UK.
Eosinophilic pustular folliculitis (EPF) of infancy is a rare disorder which may begin in the neonatal period and cause considerable parental anxiety. It must be distinguished from other causes of a pustular eruption in neonates, including infection and erythema toxicum neonatorum, and rare disorders such as transient neonatal pustular melanosis, infantile acropustulosis and Langerhans' cell histiocytosis. Skin smears and occasionally skin biopsy may be necessary to reach a diagnosis. Read More
Cutis 1999 Nov;64(5):309-14
Department of Dermatology, Stanford University School of Medicine, California, USA.
Psoriasis is a common skin disease in infants, children, and adolescents. A review of the clinical, epidemiologic, genetic, and therapeutic aspects of childhood psoriasis is presented. Population studies indicate that the first signs of psoriatic lesions occur in the pediatric age group, birth to 18 years of age, and that both genetic and environmental factors interact to precipitate the development of psoriasis. Read More
Arch Pediatr 1999 Jun;6(6):669-74
Service de dermatologie, hôpital Nord, faculté de médecine Jacques-Lisfranc, Saint-Etienne, France.
Psoriasis is a common chronic disease in childhood of yet unclear etiology. Thirty per cent of psoriatic patients experience onset of their disease before 15 years of age. Psoriasis is exceptionally congenital but may present in infancy as a napkin dermatitis. Read More
Int J Dermatol 1997 Sep;36(9):688-91
Department of Dermatology, Medical College of Wisconsin, Milwaukee, USA.
Curr Opin Pediatr 1997 Aug;9(4):396-405
Northwestern University, Children's Memorial Hospital, Chicago, IL 60614, USA.
Vesicular and pustular disorders are common in the neonatal period. Most are benign, but several serious infectious and noninfectious diseases can present in the neonate. This review focuses on the clinical features of these disorders as well as recent advances in the field. Read More
Br J Dermatol 1996 Nov;135(5):807-9
Department of Dermatology, University Clinic of Navarra, School of Medicine, Pamplona, Spain.
Arch Dermatol 1996 Nov;132(11):1365-6, 1368-9
Gulf South Medical and Surgical Institute Inc, Kenner, La, USA.
J Am Acad Dermatol 1995 Aug;33(2 Pt 2):356-60
Department of Dermatology, University Hospital Düsseldorf, Germany.
X-linked dominant chondrodysplasia punctata is a rare genodermatosis characterized by transient punctate epiphyseal calcifications and ichthyotic skin changes, usually resolving during early infancy. We describe the case of a 32-year-old woman with ichthyotic skin lesions that developed during early childhood and persisted into adulthood. Psoriasiform skin changes became evident for the first time during adulthood. Read More
Br J Dermatol 1994 Jun;130(6):800-1
Am J Hosp Pharm 1994 May;51(9):1184-92
Raabe College of Pharmacy, Ohio Northern University.
Possible new indications for the use of octreotide are discussed. In October 1988, octreotide received FDA-approved labeling for use in the management of carcinoid syndrome and vipomas. Since that time, research results and clinical experience have accumulated that suggest a potentially much broader therapeutic role for octreotide. Read More
Cutis 1992 Oct;50(4):263-6
Psoriasis Research Institute, Palo Alto, California 94301.
Psoriasis of the genitalia occurs in all age groups from infancy to the elderly. Approximately one-quarter to one-half of various epidemiologic studies report that genital psoriasis occurs with a higher frequency in males than in females. Therapeutic modalities for management of psoriasis in this site underscore the need for caution in not irritating the sensitive genital skin. Read More
Am J Dis Child 1991 Mar;145(3):341-2
Department of Pediatrics, Oregon Health Sciences University, Portland.
J Am Acad Dermatol 1991 Feb;24(2 Pt 1):186-94
Department of Dermatology, Mayo Clinic, Rochester, MN 55905.
Generalized pustular psoriasis is rare in children. Less than 100 cases have been reported. We describe 13 children with this type of psoriasis. Read More
Schweiz Rundsch Med Prax 1990 Oct;79(42):1262-6
Clinique de dermatologie, Hôpital cantonal universitaire, Genève.
Dermatoses of the hand in children are part of an original entity which can be classified in two groups: a group involving exclusively the hands and another one which is predominantly involving the hands. Attention has been focussed mostly on hand dermatoses in children (acropustulosis of infancy, papular, acrodermatitis, hand foot and mouth disease, subungual, exostosis). We discuss also the diagnostic and therapeutic aspects of scabies in children. Read More
Clin Exp Dermatol 1990 Jan;15(1):77
Hautarzt 1989 Aug;40(8):501-3
Dermatologische Universitätsklinik Ulm/Donau.
Infantile acropustulosis starts in the first few months of life with the recurrent appearance of pruritic intraepidermal pustules containing neutrophils. Predilection sites are the hands and feet. Episodes of pustular eruptions lasting from 8 to 14 days are followed by longer intervals with no symptoms. Read More
Z Hautkr 1988 Oct;63(10):871-2
Department of Dermatology, Beilinson Medical Center, Petach-Tikva, Israel.
We report on an 8-year-old female patient showing the typical lesions of acropustulosis of infancy. Our case is unusual because infantile acropustulosis mostly affects male patients and occurs during the first year of life, persisting for a period of approximately 2 years. Read More
Isr J Med Sci 1988 Feb;24(2):126-7
Department of Dermatology, Beilinson Medical Center, Petah Tikva, Israel.
Hautarzt 1988 Jan;39(1):1-4
Clinique Universitaire de Dermatologie Genf.
Infantile acropustulosis, a dermatosis first described in 1979, is reviewed on the basis of the additional information provided by the 34 new cases that have appeared in the literature since then. This dermatosis of infancy consists of chronically relapsing, highly pruritic pustules, involving the extremities, chiefly the palms and soles. The etiology is unknown. Read More