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    1 OF 197

    Efficacy and safety of switching to pasireotide in acromegaly patients controlled with pegvisomant and first-generation somatostatin analogues (PAPE study).
    J Clin Endocrinol Metab 2017 Nov 15. Epub 2017 Nov 15.
    Department of Medicine, Endocrinology section, Pituitary Center Rotterdam, Erasmus University Medical Center, Rotterdam, the Netherlands.
    Aim: To assess the efficacy and safety of pasireotide long-acting release (PAS-LAR) alone or in combination with pegvisomant by switching acromegaly patients who were well-controlled with somatostatin analogues (LA-SSAs) and pegvisomant to PAS-LAR with or without pegvisomant.

    Methods: 61 acromegaly patients were enrolled in a prospective open-label study. We included patients with an IGF-I ≤1. Read More

    Postoperative Gamma Knife radiosurgery for cavernous sinus-invading growth hormone-secreting pituitary adenomas.
    World Neurosurg 2017 Nov 16. Epub 2017 Nov 16.
    Department of Neurosurgery; Pituitary Tumor Center; Yonsei Endocrine Research Institute. Electronic address:
    Objective: We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects.

    Methods: Thirty patients who had remnant tumors only inside the CS after TSS and who consequently underwent GKS were included. They were followed for a median period of 47 months after GKS with regular hormonal and radiological examinations. Read More

    Acromegaly and Cushing's syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma.
    Clin Case Rep 2017 Nov 14;5(11):1768-1771. Epub 2017 Sep 14.
    Departments of Endocrinology and HistopathologyRoyal Devon and Exeter HospitalBarrack RoadExeterEX2 5DWUK.
    A 60-year-old man with a pre-existing stable sacrococcygeal teratoma developed acromegaly, ectopic Cushing's syndrome, and 5HIAA secretion. To our knowledge, this represents the first reported case of ACTH and serotonin secretion, and likely GHRH or GH cosecretion, from a sacrococcygeal teratoma in an adult. Read More

    Obstructive sleep apnea characteristics in patients with well-controlled acromegaly and their compliance with positive airway pressure therapy
    Turk J Med Sci 2017 11 13;47(5):1348-1353. Epub 2017 Nov 13.
    Background/aim: Acromegaly is often associated with obstructive sleep apnea syndrome (OSAS) with a frequency between 40% and 80%. The aim of the present study was to evaluate the clinical and polysomnographic characteristics of acromegaly patients with sleep apnea symptoms and to identify positive airway pressure (PAP) adherence in acromegaly patients with OSAS diagnosis.Materials and methods: Twenty-eight well-controlled acromegaly patients (17 males, mean age 48. Read More

    Patient-centered assessment on disease burden, quality of life, and treatment satisfaction associated with acromegaly.
    J Investig Med 2017 Nov 18. Epub 2017 Nov 18.
    Department of Global Health Management and Policy, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
    The study aimed to assess the economic burden, health-related quality of life (HRQoL), and acromegaly treatment satisfaction in the USA. A web-based, cross-sectional survey was distributed to members of Acromegaly Community. Data related to comorbidities, treatment patterns, and treatment satisfaction were collected. Read More

    Impact of transsphenoidal surgery on asymptomatic cardiomyopathy in patients with acromegaly. A single-blinded study.
    Neurol India 2017 Nov-Dec;65(6):1312-1316
    Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Background: Patients with acromegaly have 2-3 times the expected mortality rates primarily due to cardiovascular risks. Echocardiographic studies showing improvement of cardiac function following transsphenoidal surgery (TSS) are limited.

    Materials And Methods: All patients with acromegaly underwent preoperative echocardiography and tissue Doppler (Philips i33, 3D ECHO) for assessment of cardiac indices. Read More

    [Bone quality in patients with acromegaly].
    Vnitr Lek 2017 ;63(9):589-592
    The impact of acromegaly on bone and the risk of fractures has not been sufficiently investigated. GH hypersecretion stimulates bone turnover, leading to an increase in bone turnover markers. Normal or even increased bone mineral density (BMD) in comparison to healthy controls have been reported, but there are some works where decreased BMD was observed among acromegaly patients with hypogonadism, particularly at lumbar spine. Read More

    Long-term safety of long-acting octreotide in patients with diabetic retinopathy: results of pooled data from 2 randomized, double-blind, placebo-controlled phase 3 studies.
    Endocrine 2017 Nov 7. Epub 2017 Nov 7.
    Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Naples, Italy.
    Purpose: Octreotide (OCT) has been successfully used for treatment of acromegaly and neuroendocrine tumors for more than 30 years. However, long-term safety of OCT has not been documented in placebo-controlled setting. This present analysis pooled safety data from two similarly-designed, randomized, and placebo-controlled studies to evaluate long-term safety of long-acting OCT (20, 30 mg); targeted post-hoc analyzes focused on cardiac, hepatic, and renal safety. Read More

    Unruptured Internal Carotid Artery Aneurysm Associated with Functional Pituitary Adenoma: A True Association.
    Asian J Neurosurg 2017 Oct-Dec;12(4):701-704
    Department of Neurosurgery, Neurosciences Centre, AIIMS, New Delhi, India.
    Detection of incidental intracranial aneurysm on neuroimaging can be associated with pituitary adenoma; however, such association is extremely rare. However, aneurysm with extension into the sella is extremely rare, and increases the risk of inadvertent intraoperative rupture, if trans-sphenoidal decompression is attempted either using endoscopic or microscopic surgical approach. Hanak et al. Read More

    Has acromegaly been diagnosed earlier?
    J Clin Neurosci 2017 Nov 4. Epub 2017 Nov 4.
    Department of Neurosurgery, Brain Research Institute, Niigata University, Japan.
    Purpose: We investigated whether acromegaly has been diagnosed earlier at the Niigata Medical and Dental University Hospital.

    Methods: Patients with acromegaly (n = 81) who underwent their first transsphenoidal surgery from 2006 to 2015 were reviewed. Two groups were compared: those who underwent surgery between 2006 and 2010 (n = 35) and those who underwent surgery between 2011 and 2015 (n = 46). Read More

    Trends in surgery, hospital admissions and imaging for pituitary adenomas in Australia.
    Endocrine 2017 Nov 4. Epub 2017 Nov 4.
    Endocrine and Metabolic Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA, Australia.
    Purpose: There is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia.

    Methods: Australian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed. Read More

    Risk of left ventricular hypertrophy and diastolic and systolic dysfunction in Acromegaly: A meta-analysis.
    J Clin Neurosci 2017 Oct 30. Epub 2017 Oct 30.
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Beijing 100730, People's Republic of China; China Pituitary Disease Registry Center, No. 1 Shuaifuyuan, Beijing 100730, People's Republic of China. Electronic address:
    Objective: To perform a meta-analysis to evaluate the exact incidence of left ventricular hypertrophy, diastolic dysfunction and systolic dysfunction in patients with treatment-naïve acromegaly.

    Methods: PubMed, EMBASE, Ovid MEDLINE, the Cochrane Library, Scopus, Science Citation Index Expand and PubMed Central were searched for eligible studies. Eligible data were extracted and evaluated using a fixed- or random-effects model. Read More

    Colonoscopy examination requires a longer time in patients with acromegaly than in other individuals.
    Endocr J 2017 Oct 28. Epub 2017 Oct 28.
    Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama 700-8558, Japan.
    This study aimed to determine the prevalence of colorectal neoplasms and to investigate the rate of and time required for cecal intubation in patients with acromegaly. A database search performed at our institution identified 29 patients with acromegaly who underwent colonoscopy. Data regarding the endoscopic, biological, and pathological examinations performed were retrospectively reviewed from the clinical records. Read More

    How to improve effectiveness of pegvisomant treatment in acromegalic patients.
    J Endocrinol Invest 2017 Oct 28. Epub 2017 Oct 28.
    Dipartimento di Patologia Umana dell'adulto e dell'età evolutiva "G. Barresi", AOU Policlinico G. Martino, University of Messina, Via Consolare Valeria, 1, 98125, Messina, Italy.
    Purpose: Pegvisomant (PEGV) treatment in acromegaly patients resistant to somatostatin analogues is less effective in the real life than in clinical trials. This is a multicenter, observational, retrospective, longitudinal study. The aim was to detect characteristics which improve long-term PEGV effectiveness. Read More

    Double pituitary adenomas associated with persistent trigeminal artery: a rare case report and the review of literature.
    Neurosurg Rev 2017 Oct 27. Epub 2017 Oct 27.
    Department of Neurosurgery, Kurume University School of Medicine, Asahi-machi 67, Kurume-shi, Fukuoka, 830-0011, Japan.
    Multiple pituitary adenomas are rare. We present a quite unique case of double pituitary adenomas associated with persistent trigeminal artery (PTA) treated by endoscopic surgery. To the best of our knowledge, this is the first report in the literature. Read More

    Radiographic Predictors of Difficult Laryngoscopy in Acromegaly Patients.
    J Neurosurg Anesthesiol 2017 Oct 25. Epub 2017 Oct 25.
    Departments of *Anesthesiology and Pain Medicine †Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
    Background: Patients with acromegaly have a high risk of difficult laryngoscopy. However, clinical predictors, such as upper lip bite test or modified Mallampati class, show limited predictive performance for difficult laryngoscopy in such patients. In this retrospective study, we evaluated radiographic indices obtained from skull lateral x-ray and ostiomeatal unit computed tomography images to predict difficult laryngoscopy in acromegaly patients. Read More

    AIP mutations in Brazilian patients with sporadic pituitary adenomas: a single-center evaluation.
    Endocr Connect 2017 Oct 26. Epub 2017 Oct 26.
    M Gadelha, Internal Medicine and Endocrine Unit, Universidade Federal do Rio de Janeiro Hospital Universitario Clementino Fraga Filho, Rio de Janeiro, Brazil.
    Aryl hydrocarbon receptor-interacting protein (AIP) gene mutations (AIPmut) are the most frequent germline mutations found in apparently sporadic pituitary adenomas (SPA). Our aim was to evaluate the frequency of AIPmut among young Brazilian patients with SPA. We performed an observational cohort study between 2013-2016 in a single referral center. Read More

    Microsurgical therapy of pituitary adenomas.
    Endocrine 2017 Oct 24. Epub 2017 Oct 24.
    Department of Neurosurgery and Gamma Knife Radiosurgery, San Raffaele University Health Institute, Milan, Italy.
    Purpose: We report the efficacy and safety of transsphenoidal microsurgery in a large and homogeneous cohort of patients with pituitary adenomas (PAs) treated at a single Institute by a single neurosurgeon.

    Methods: A total of 2145 consecutive patients undergoing first surgery for a PA were included: 795 (37.1%) had a nonfunctioning pituitary adenoma (NFPA), 595 (27. Read More

    Transsphenoidal Surgery for Pituitary Tumors and Other Sellar Masses.
    Vet Clin North Am Small Anim Pract 2018 Jan 20;48(1):129-151. Epub 2017 Oct 20.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, PO Box 646610, Pullman, WA 99164-6610, USA.
    Transsphenoidal surgery is an option for dogs and cats with functional and nonfunctional pituitary masses or other sellar and parasellar masses. An adrenocorticotropic hormone-secreting tumor causing Cushing disease is the most common clinically relevant pituitary tumor in dogs, and the most common pituitary tumor seen in cats is a growth hormone-secreting tumor causing acromegaly. Transsphenoidal surgery can lead to rapid resolution of clinical signs and provide a cure for these patients. Read More

    The assessment of total antioxidant capacity and superoxide dismutase levels, and the possible role of manganese superoxide dismutase polymorphism in acromegaly.
    Endocr J 2017 Oct 17. Epub 2017 Oct 17.
    Department of Endocrinology and Metabolism, Bezmialem Vakif University, Vatan Caddesi, 34093, Istanbul, Turkey.
    Oxidative status is attributed to endothelial dysfunction and might be one of the key mechanisms of endothelial dysfunction in acromegaly. In this study, we aimed to investigate the effect of acromegaly on superoxide dismutase (SOD) and total antioxidant capacity (TAC) levels, and the possible influence of human manganese superoxide dismutase (MnSOD) polymorphism on these levels. 51 acromegaly patients and 57 age and sex matched healthy subjects were recruited to the study in Bezmialem Vakif University Hospital between 2011 and 2014. Read More

    Clinical profile of silent growth hormone pituitary adenomas; higher recurrence rate compared to silent gonadotroph pituitary tumors, a large single center experience.
    Endocrine 2017 Dec 17;58(3):528-534. Epub 2017 Oct 17.
    Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
    Purpose: Study and comparison of characteristics of silent growth hormone adenomas (SGHA), silent corticotroph adenomas (SCA), and silent gonadotroph adenomas (SGA) in a single institution cohort of surgically treated pituitary adenomas.

    Methods: Retrospective analysis of SGHA surgically resected over 10 years: SGHA was defined as no clinical or biochemical evidence of acromegaly and positive GH immunostaining.

    Results: Of 814 pituitary surgeries; 2. Read More

    [Diagnostics and treatment of acromegaly : Necessity for targeted monitoring of comorbidities].
    Internist (Berl) 2017 Nov;58(11):1171-1182
    Innere Medizin, Endokrinologie und Klinische Chemie, Max-Planck-Institut für Psychiatrie, München, Deutschland.
    Acromegaly is a rare and severe condition, presenting with typical signs and symptoms. The diagnosis is often initially made years after the first manifestations of the disease. In more than 99% of patients the disease is caused by a benign pituitary tumor that secretes growth hormone (GH). Read More

    [Familial isolated pituitary adenomas (FIPA). Case report of four families and review of literature.]
    Endokrynol Pol 2017 Oct 12. Epub 2017 Oct 12.
    Katedra i Klinika Endokrynologii Uniwersytetu Medycznego w Lublinie.
    BackgroundThe majority of pituitary adenomas are sporadic, but about 5% of them occur in a familial setting, predominantly in multiple endocrine neoplasia type 1 and Carney complex. Familial isolated pituitary adenomas (FIPA), unrelated to the syndromes mentioned above, were also described. The clinical course of FIPA differs significantly from sporadic cases, and is characterized by a larger tumor size, more aggressive course and younger patients' age at the moment of recognition. Read More

    Diagnosis and treatment of TSH-secreting adenomas: review of a longtime experience in a reference center.
    J Endocrinol Invest 2017 Oct 11. Epub 2017 Oct 11.
    Neuroendocrine Unit, Division of Endocrinology and Metabolism, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 806, Vila Clementino, São Paulo, CEP 04023-062, Brazil.
    Purpose: TSH-secreting pituitary adenomas are among the less prevalent pituitary tumors, corresponding to 0.9-1.5% of all pituitary adenomas in surgical series. Read More

    Targeting either GH or IGF-I during somatostatin analogue treatment in patients with acromegaly: a randomized multicentre study.
    Eur J Endocrinol 2018 Jan 9;178(1):67-76. Epub 2017 Oct 9.
    Department of Endocrinology and Internal MedicineAarhus University Hospital, Aarhus, Denmark
    Context: Discordant GH and IGF-I values are frequent in acromegaly. The clinical significance and its dependence on treatment modality and of glucose-suppressed GH (GHnadir) measurements remain uncertain.

    Objective: To evaluate the effects of targeting either IGF-I or GH during somatostatin analogue (SA) treatment. Read More

    Left ventricular twist is impaired in acromegaly: Insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study.
    J Clin Ultrasound 2017 Oct 9. Epub 2017 Oct 9.
    2nd Department of Medicine and Cardiology Centre, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.
    Introduction: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone-secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls.

    Methods: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57. Read More

    Long-term follow-up of patients with elevated IGF-1 and nadir GH > 0.4 µg/L but < 1 µg/L.
    Arch Endocrinol Metab 2017 Sep 18. Epub 2017 Sep 18.
    Serviço de Endocrinologia, Santa Casa de Belo Horizonte, MG, Brasil.
    Objective: To report the results of initial investigation and after 5 years of patients with a suspicious clinical scenario for acromegaly, elevated IGF-1, and nadir GH during an oral glucose tolerance test (OGTT) > 0.4 µg/L but < 1 µg/L.

    Subjects And Methods: Seventeen patients who had elevated IGF-1 (outside puberty and pregnancy) in two measurements and GH between 0. Read More

    Fatal Carney Complex in Siblings Due to De Novo Large Gene Deletion.
    J Clin Endocrinol Metab 2017 Nov;102(11):3924-3927
    Department of Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom.
    Context: Carney complex (CNC) is a rare multiple neoplasia syndrome involving cardiac, endocrine, neural, and cutaneous tumors and a variety of pigmented skin lesions. CNC can be inherited as an autosomal dominant trait, but in about one-third of patients, the disease is caused by de novo mutation in the PRKAR1A gene localized on chromosome 17q22-24. Most of the mutations include single base substitutions and small deletions/insertions not exceeding 15 base pairs. Read More

    Acromegaly with hypophosphataemia: McCune-Albright syndrome.
    BMJ Case Rep 2017 Sep 28;2017. Epub 2017 Sep 28.
    Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
    A 38-year-old man presented with excessive height gain and progressive enlargement of the extremities since childhood. This was compounded by lower limb deformities over the past 5 years. On examination, his height was 196 cm, he had macroglossia, acral enlargement, seborrhoea, hyperhidrosis-suggesting acrogigantism. Read More

    An unusual pituitary adenoma coexistent with bilateral meningiomas: case report.
    Br J Neurosurg 2017 Sep 29:1-2. Epub 2017 Sep 29.
    a Department of Neurosurgery , Queen's Medical Centre , Nottingham , UK.
    The association of pituitary adenomas and meningioma is rare. We present the case of a 46 year old lady who initially presented with large bilateral meningiomas and acromegaly. Histology demonstrated mammosomatotroph cell adenoma co-expressing Growth Hormone. Read More

    Diabetic ketoacidosis in acromegaly; a rare complication precipitated by corticosteroid use.
    Diabetes Res Clin Pract 2017 Sep 19;134:29-37. Epub 2017 Sep 19.
    Department of Endocrinology, Austin Health, Level 2 Centaur Building, Repatriation Campus Heidelberg West, Victoria 3084, Australia; Department of Medicine, Austin Health and the University of Melbourne (Austin Campus), Parkville, VIC 3010, Australia. Electronic address:
    Diabetic ketoacidosis has been described in the literature as a rare possible initial presentation of acromegaly before a diagnosis of acromegaly is eventually made. Indeed, diabetic ketoacidosis is a recognised complication of acromegaly. There are a number of factors that can predispose patients with acromegaly to diabetes as well as to diabetic ketoacidosis. Read More

    Body Composition and Ectopic Lipid Changes With Biochemical Control of Acromegaly.
    J Clin Endocrinol Metab 2017 Nov;102(11):4218-4225
    Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114.
    Context: Acromegaly is characterized by growth hormone (GH) and insulinlike growth factor-1 (IGF-1) hypersecretion, and GH and IGF-1 play important roles in regulating body composition and glucose homeostasis.

    Objective: The purpose of our study was to investigate body composition including ectopic lipids, measures of glucose homeostasis, and gonadal steroids in patients with active acromegaly compared with age-, body mass index (BMI)-, and sex-matched controls and to determine changes in these parameters after biochemical control of acromegaly.

    Design: Cross-sectional study of 20 patients with active acromegaly and 20 healthy matched controls. Read More

    Progress in the formulation and delivery of somatostatin analogs for acromegaly.
    Ther Deliv 2017 Oct;8(10):867-878
    Veterinary Sciences Centre, School of Veterinary Medicine & Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
    A 14 amino acid cystin bridge containing neuropeptide was discovered in 1973 and designated as growth hormone-inhibiting hormone, in other words, somatostatin. Its discovery led to the synthesis of three analogs which were licensed for the treatment of acromegaly: octreotide, lanreotide and pasireotide. Somatostatin analogs are currently approved only as either subcutaneous or intramuscular long-acting injections. Read More

    [The mouth of patients with acromegaly].
    Presse Med 2017 Sep 22;46(9):831-837. Epub 2017 Sep 22.
    CHRU de Lille, hôpital Huriez, service d'endocrinologie, diabétologie et maladies métaboliques, rue Polonowski, 59037 Lille cedex, France. Electronic address:
    Orofacial changes are frequent in acromegaly. Their evolution is slowly progressive. The lips (everted and thickened), the mandibular morphology (prognathism), the tongue (macroglossia), the soft palate and the uvula (increased and thickened), the parodontis (gingival hyperplasia, paradontitis), the teeth (increased interdental spaces, hypercementosis, increased dental mobility, multiple tooth loss) are concerned. Read More

    Guidelines versus real life practice: the case of colonoscopy in acromegaly.
    Pituitary 2017 Sep 21. Epub 2017 Sep 21.
    Department of Medicine (DIMED), Padua University Hospital, via Giustiniani 2, 35128, Padua, Italy.
    Purpose: The aim of this study is to investigate guideline application and colonoscopy findings in real-life practice in acromegaly.

    Methods: We conducted a retrospective observational non-interventional and cross-sectional analysis on 146 patients with acromegaly (ACRO) referred to our clinic. We evaluated colonoscopy data, focusing on the correlation between colonoscopy findings and hormonal/metabolic values. Read More

    Growth Hormone's Effect on Adipose Tissue: Quality versus Quantity.
    Int J Mol Sci 2017 Jul 26;18(8). Epub 2017 Jul 26.
    The Diabetes Institute at Ohio University, 108 Konneker Research Labs, Ohio University, Athens, OH 45701, USA.
    Obesity is an excessive accumulation or expansion of adipose tissue (AT) due to an increase in either the size and/or number of its characteristic cell type, the adipocyte. As one of the most significant public health problems of our time, obesity and its associated metabolic complications have demanded that attention be given to finding effective therapeutic options aimed at reducing adiposity or the metabolic dysfunction associated with its accumulation. Growth hormone (GH) has therapeutic potential due to its potent lipolytic effect and resultant ability to reduce AT mass while preserving lean body mass. Read More

    The efficacy of medical treatment in patients with acromegaly in clinical practice.
    Endocr J 2017 Sep 20. Epub 2017 Sep 20.
    Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    Although somatostatin analogues (SSAs) are recommended as the first-line medical therapy for acromegaly, dopamine agonists (DAs) are also a therapeutic option for treatment. We aimed to assess and compare the efficacies of DAs and SSAs in treating acromegaly in clinical practice. We included 89 patients with acromegaly who took DAs (bromocriptine [BCT], n = 63; cabergoline [CAB], n = 11) or SSAs (n = 15) as a primary medical therapy for more than 3 months in the Seoul National University Hospital. Read More

    Fibroblast Growth Factor 21 in Patients with Acromegaly.
    Exp Clin Endocrinol Diabetes 2017 Sep 20. Epub 2017 Sep 20.
    Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Wroclaw, Poland.
    Introduction The goal of the study was to investigate fibroblast growth factor-21 (FGF-21) levels in acromegalic patients in relation to the disease activity and to compare them with controls. Further, we aimed to evaluate the associations between FGF-21 and random growth hormone (GH), insulin-like growth factor-1 (IGF-1), metabolic and anthropometric parameters. Materials and methods The study group consisted of 50 acromegalic patients divided into 3 subgroups on the basis of disease activity (AA - active acromegaly, CD - controlled disease, CA - cured acromegaly). Read More

    Microsurgical versus endoscopic transsphenoidal resection for acromegaly: a systematic review of outcomes and complications.
    Acta Neurochir (Wien) 2017 Nov 14;159(11):2193-2207. Epub 2017 Sep 14.
    Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA, USA.
    Purpose: The aim of this systematic review is to evaluate the long-term endocrine outcomes and postoperative complications following endoscopic vs. microscopic transsphenoidal resection (TSR) for the treatment of acromegaly.

    Methods: A literature review was performed, and studies with at least five patients who underwent TSR for acromegaly, reporting biochemical remission criteria and long-term remission outcomes were included. Read More

    Association between FTO gene polymorphisms and HDL cholesterol concentration may cause higher risk of cardiovascular disease in patients with acromegaly.
    Pituitary 2017 Sep 14. Epub 2017 Sep 14.
    Department of Endocrinology, Diabetes and Isotope Therapy, Wroclaw Medical University, Pasteura 4, 50-367, Wroclaw, Poland.
    Introduction: Cardiovascular diseases are main cause of morbidity and mortality in acromegaly. Polymorphisms of FTO gene are associated with obesity and increased risk of CVD (independently of BMI). Aim of this study was to investigate the allele frequencies of two FTO gene polymorphisms: rs9939609 and rs9930506 in patients with acromegaly and to examine the association of FTO gene polymorphisms with BMI and selected metabolic parameters. Read More

    [Acromegaly features in the aging population].
    Pan Afr Med J 2017 4;27:169. Epub 2017 Jul 4.
    Service d'Endocrinologie, Diabétologie et Nutrition, CHU Hassan II de Fès, Maroc.
    Somatotroph adenomas are rare in the aging population. Diagnosis of somatotroph adenomas is often long delayed and they are characterized by atypical clinical picture. Their diagnostic criteria are similar to those used for younger patients. Read More

    A Case of Acromegaly in which a Pituitary Gland Tumor was Reduced Significantly by Administering Octreotide Long Acting Release (LAR) and Could Be Removed Surgically.
    J UOEH 2017 ;39(3):241-245
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.
    A 54-year-old woman was admitted to our hospital for detailed examination of acromegaly because she noticed bilateral hand and finger swelling at the age of 43 and plantar thickening, facial changes and unclear articulation at the age of 49. She had prominent brow ridges, mandibular protrusion, and enlargement of the hands, feet, nasal wings, lips and tongue. Her growth hormone (GH) level was 39. Read More

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