9,973 results match your criteria Acromegaly


The Use and Abuse of Human Growth Hormone in Sports.

Sports Health 2018 Jun 1:1941738118782688. Epub 2018 Jun 1.

Department of Family Medicine, Sports Medicine Section, University of Washington, Seattle, Washington.

Context: Recombinant human growth hormone (rHGH) has become a target of abuse in the sporting world. Conversely, sports medicine clinicians may encounter athletes using rHGH to achieve normalcy in the context of growth hormone (GH) deficiency.

Evidence Acquisition: Medline and PubMed databases were queried using the following keywords: GH, GH physiology, GH deficiency, acromegaly, GH athlete, GH sports, GH athletic performance, and GH deficiency concussion. Read More

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June 2018
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The posterior pharyngeal wall thickness is associated with OSAHS in patients with acromegaly and correlates with IGF-1 levels.

Endocrine 2018 Jun 21. Epub 2018 Jun 21.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, 100730, Beijing, People's Republic of China.

Purpose: To evaluate the incidence of obstructive sleep apnea-hypopnea syndrome (OSAHS), explore the structural changes in pharyngeal soft tissue underlying OSAHS development and analyze the correlation between hormone levels and pharyngeal soft tissue changes in patients with untreated acromegaly.

Methods: Twenty-five patients with untreated acromegaly were prospectively enrolled. Pituitary hormones were tested, sellar magnetic resonance imaging was confirmed, overnight polysomnography was conducted, and upper airway computed tomography was performed on these patients. Read More

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Spontaneous improvement of cutis verticis gyrata secondary to acromegaly following surgical treatment of pituitary adenoma.

J Dtsch Dermatol Ges 2018 Jun 21. Epub 2018 Jun 21.

Department of Endocrinology, Hospital Infanta Cristina, Parla, Madrid, Spain.

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[Pituitary lactotroph adenomas resistant to dopamine agonist treatment: histological and immunohistochemical characteristics].

Arkh Patol 2018 ;80(3):34-39

National Medical Research Center of Endocrinology, Ministry of Health of Russia, Moscow, Russia.

Objective: To present the histological and immunohistochemical characteristics of pituitary lactotroph adenomas (PLAs) resistant to dopamine agonist treatment.

Subject And Methods: The investigators examined paraffin-embedded blocks and histological sections obtained from 19 patients (13 women, 6 men), whose median age was 29 (19, 38) years, after surgical treatment (adenomectomy) for PLAs resistant to dopamine agonist treatment. Immunohistological examination was performed using antibodies against prolactin (PRL), growth hormone (GH), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), type 2 dopamine receptors (DR), estrogen receptors-α (ERα), the proliferation marker Ki-67, and the endothelial cell marker CD34. Read More

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January 2018
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Analgesic effect of long-acting somatostatin receptor agonist pasireotide in a patient with acromegaly and intractable headaches.

BMJ Case Rep 2018 Jun 19;2018. Epub 2018 Jun 19.

Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA.

A 22-year-old woman presented with worsening vision loss and headaches. A diagnosis of acromegaly was confirmed after detection of an invasive pituitary macroadenoma and biochemical testing. Despite two attempts of surgical debulking of the tumour and administration of long-acting octreotide and cabergoline, growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were uncontrolled. Read More

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June 2018
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Giant pituitary adenoma: histological types, clinical features and therapeutic approaches.

Endocrine 2018 Jun 16. Epub 2018 Jun 16.

Department of Endocrinology. Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.

Giant pituitary adenomas comprise about 6-10% of all pituitary tumors. They are mostly clinically non-functioning adenomas and occur predominantly in males. The presenting symptoms are usually secondary to compression of neighboring structures, but also due to partial or total hypopituitarism. Read More

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Endoscopic endonasal approach to the GH secreting pituitary adenomas: endocrinological outcome in 68 patients.

World Neurosurg 2018 Jun 11. Epub 2018 Jun 11.

Pituitary Clinic, Brain and Spinal Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurological Surgery, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: Endoscopic endonasal approach has recently become an acceptable option for resection of all pituitary adenomas. We assessed biochemical outcome of endoscopic endonasal surgery in growth hormone (GH) secreting adenomas including remission rate, predictors of remission and associated complications.

Methods: Sixty eight consecutive patients with acromegaly who underwent endoscopic endonasal surgery have been analyzed prospectively. Read More

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Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma.

Horm Metab Res 2018 Jun 12. Epub 2018 Jun 12.

Hacettepe Medical School, Department of Endocrinology and Metabolism, Hacettepe University, Ankara, Turkey.

The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and acromegaly. Thirty-one patients with acromegaly, 28 patients with prolactinoma, and 33 healthy individuals were included in the study. Serum concentrations of RANKL, OPG, bone alkaline phosphatase (bone ALP), osteocalcin (OC), C-terminal telopeptide of type 1 collagen (CTX), procollagen type 1 N-terminal propeptide (P1NP) and urine deoxypyridinoline (DPD) levels were detected and bone mineral density (BMD) was measured. Read More

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Metabolic Complications of Acromegaly.

Front Horm Res 2018 5;49:20-28. Epub 2018 Apr 5.

Diabetes is recognized as one of the most common acromegaly co-morbidities with a prevalence ranging 20-53%, while over one-third of these patients have an altered lipid profile. In fact, as in the non-acromegalic population, carbohydrate and lipid metabolism abnormalities are closely linked. Long term exposure to an excess of growth hormone (GH) and Insulin-like growth factor-1 concentrations results in insulin resistance and an increased hepatic glucose production. Read More

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April 2018
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The Role of Different Molecular Markers in Papillary Thyroid Cancer Patients with Acromegaly.

Exp Clin Endocrinol Diabetes 2018 Jun 11. Epub 2018 Jun 11.

Division of Endocrinology-Metabolism and Diabetes, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.

Purpose: Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules.

Methods: We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015. Read More

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Quantification of specific growth patterns and frequency of the empty sella phenomenon in growth hormone-secreting pituitary adenomas.

Eur J Radiol 2018 Jul 8;104:79-86. Epub 2018 May 8.

Department of Neurosurgery, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, D-72076 Tuebingen, Germany.

Purpose: To assess and quantify the prevalence and co-occurence of a sellar floor lowering and empty sella phenomenon in patients with GH (growth hormone)-secreting pituitary adenoma.

Methods: A total number of 159 acromegalic patients were included in this study, as well as two control groups (150 patients with non-GH-secreting adenomas and 50 patients without pituitary adenomas). Magnetic resonance images of all patients were evaluated for presence of an empty sella, downward and lateral tumor extension, and maximum superoinferior diameter of the mass. Read More

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July 2018
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Pachydermoperiostosis Mimicking Acromegaly: A Case Report.

Indian Dermatol Online J 2018 May-Jun;9(3):182-184

Department of Dermatology, Venereology and Leprosy, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Pachydermoperiostosis is a rare, hereditary disease commonly presenting with digital clubbing, pachyderma, and periosteal hypertrophy. Coarsening of facial features and spade-like enlargement of hands and feet may give rise to a diagnostic dilemma between pachydermoperiostosis and acromegaly. This report highlights a case of a 36-year-old man who presented with broadening of hands and feet, facial skin thickening, and edematous and drooping eyelids for the last 10 years. Read More

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June 2018
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Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study.

Int J Endocrinol 2018 26;2018:3015854. Epub 2018 Apr 26.

Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, Shanghai 200040, China.

Purpose: To evaluate the change in glucose tolerance in treatment-naïve patients with acromegaly after administration of SSA and to identify predictive factors of glucose impairment during SSA therapy.

Methods: Oral glucose tolerance testing (OGTT) was performed on 64 newly diagnosed and treatment-naïve patients with acromegaly both at pretreatment and 3 months after initiation of treatment with long-acting SSA. Insulin resistance (IR) was assessed by homeostatic model assessment- (HOMA-) IR and IS. Read More

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April 2018
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Characteristics of the upper respiratory tract in patients with acromegaly and correlations with obstructive sleep apnoea/hypopnea syndrome.

Sleep Med 2018 May 9;48:27-34. Epub 2018 May 9.

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China; China Pituitary Disease Registry Centre, Chinese Pituitary Adenoma Cooperative Group, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China. Electronic address:

Objective: To explore the radiological characteristics of the upper respiratory tract and their correlations with obstructive sleep apnoea/hypopnea syndrome (OSAHS) in patients with acromegaly.

Methods: Computed tomography (CT) and magnetic resonance imaging (MRI) were performed in untreated patients with acromegaly placed in straight (SHP) and extended head positions (EHP). Overnight polysomnography was performed to evaluate OSAHS, and the apnoea/hypopnea index (AHI) was measured. Read More

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Anaesthetic management and complications during hypophysectomy in 37 cats with acromegaly.

J Feline Med Surg 2018 May 1:1098612X18778697. Epub 2018 May 1.

2 Department of Clinical Science and Services, Royal Veterinary College, Hatfield, UK.

Objectives The aim of this study was to describe the anaesthetic management and perianaesthetic complications encountered during hypophysectomy surgery in acromegalic cats. We explored relationships between animal demographic data, the anaesthetic protocol used and presence of perioperative complications. Methods Cats having undergone hypophysectomy surgery for the treatment of feline acromegaly at a single veterinary referral hospital were identified from hospital records. Read More

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Is elevated urotensin II level a predictor for increased cardiovascular risk in subjects with acromegaly?

J Endocrinol Invest 2018 May 26. Epub 2018 May 26.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Bozyaka, 35170, Izmir, Turkey.

Purpose: Acromegaly is a rare disorder existed in the result of overproduction of growth hormone (GH). The disorder is associated with increased cardiovascular risk factors and metabolic abnormalities. Urotensin II (UII), a secreted vasoactive peptide hormone, belonging somatostatin superfamily, plays an essential role in atherosclerosis and glucose metabolism. Read More

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Epidemiology of acromegaly in Italy: analysis from a large longitudinal primary care database.

Endocrine 2018 May 24. Epub 2018 May 24.

Endocrinology, Department of Internal Medicine and Medical Specialties (DIMI), University of Genoa, Genoa, Italy.

Purpose: Epidemiological data are pivotal for the estimation of disease burden in populations.

Aim: Of the study was to estimate the incidence and prevalence of acromegaly in Italy along with the impact of comorbidities and hospitalization rates as compared to the general population.

Methods: Retrospective epidemiological study (from 2000 to 2014) and case control-study. Read More

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Acromegalic Cardiomyopathy: An Overview of Risk Factors, Clinical Manifestations, and Therapeutic Options.

Cardiol Rev 2018 May 23. Epub 2018 May 23.

Division of Cardiology, New York Medical College/Westchester Medical Center, Valhalla, NY and.

Acromegaly is a rare endocrine disorder that carries a significant burden of cardiovascular morbidity and mortality. Abnormalities of the growth hormone/insulin-like growth factor-1 axis in acromegaly lead to the characteristic CV manifestations of this disease. One hallmark feature of the disease is acromegalic cardiomyopathy, a syndrome of progressive cardiac dysfunction characterized by left ventricular hypertrophy, diastolic dysfunction, and combined systolic and diastolic dysfunction in the very advanced stage. Read More

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Pediatric Pituitary Adenomas: Early and Long-Term Surgical Outcome in a Series of 85 Consecutive Patients.

Neurosurgery 2018 May 22. Epub 2018 May 22.

Department of Neurosurgery and Gamma Knife Radiosurgery, Vita-Salute University, Scientific Institute San Raffaele, Milan, Italy.

Background: Young age has been reported as a negative prognostic factor for pituitary adenomas (PAs). They are very uncommon in children and adolescents; therefore, surgical outcomes are poorly described.

Objective: To report results of microsurgical transsphenoidal approach (MTSA) in pediatric PAs. Read More

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Screening of acromegaly in adults with obstructive sleep apnea: is it worthwhile?

Endocrine 2018 Jul 22;61(1):4-6. Epub 2018 May 22.

Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Endocriniennes Rares de l'Hypophyse, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre & UMRS 1185, Fac Med Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, F-94276, France.

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A randomised, open-label, parallel group phase 2 study of antisense oligonucleotide therapy in acromegaly.

Eur J Endocrinol 2018 May 22. Epub 2018 May 22.

M Bidlingmaier, Endocrine Laboratory, Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.

Objective: ATL1103 is a second-generation antisense oligomer targeting the human GH receptor. This phase 2 randomised, open-label, parallel-group study assessed the potential of ATL1103 as a treatment for acromegaly.

Design: 26 patients with active acromegaly (IGF-I >130% upper limit of normal) were randomised to subcutaneous ATL1103 200 mg either once- or twice-weekly for 13 weeks, and monitored for a further 8-week washout period. Read More

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Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly.

J Vet Intern Med 2018 May 21. Epub 2018 May 21.

Flint Animal Cancer Center, Colorado State University, Fort Collins, Colorado.

Background: Conventional fractionated radiotherapy has been shown to be partially effective for management of pituitary tumors in cats that cause acromegaly and diabetes mellitus (DM), but, the efficacy and safety of stereotactic radiation therapy (SRT) as a treatment for acromegalic cats has not been described.

Hypothesis: Stereotactic radiation therapy is an effective and safe treatment for controlling acromegaly associated with pituitary adenomas in cats. Additionally, SRT-treated acromegalic cats with DM will experience a decrease in insulin requirements after radiation therapy. Read More

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Screening for comorbid conditions in patients enrolled in the SODA registry: a 2-year observational analysis.

Endocrine 2018 May 16. Epub 2018 May 16.

Division of Endocrinology, Diabetes and Metabolism and Pituitary Center, Johns Hopkins University, 1830 East Monument Street #333, Baltimore, MD, 21287, USA.

Purpose: This 2-year analysis assessed frequency of comorbidities and comorbidity screening in the Somatuline (lanreotide, LAN) Depot for Acromegaly (SODA) registry.

Methods: Patient data collected included pituitary hormone deficiencies, sleep studies, echocardiograms, gallbladder sonographies, colonoscopies, and glycated hemoglobin (HbA1c) levels. Insulin-like growth factor-1 (IGF-1) and growth hormone levels in patients with (DM) and without (non-DM) diabetes mellitus were analyzed. Read More

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Mortality in acromegaly decreased in the last decade: a systematic review and meta-analysis.

Eur J Endocrinol 2018 Jul 15;179(1):59-71. Epub 2018 May 15.

Department of Internal MedicineBotucatu Medical School, State University/UNESP, Sao Paulo, Brazil

Objective: To compare the acromegaly mortality rates with those expected for the general population from studies published before and after 2008.

Methods: We performed a systematic review and included observational studies in which the number of deaths observed in acromegaly was compared with the expected mortality for the general population mortality observed/expected (O/E). The following electronic databases were used as our data sources: EMBASE, MEDLINE and LILACS. Read More

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Stereotactic Radiosurgery for Acromegaly: An International Multicenter Retrospective Cohort Study.

Neurosurgery 2018 May 10. Epub 2018 May 10.

Department of Neurosurgery, University of Virginia, Charlottesville, Virginia.

Background: Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone secreting pituitary adenoma, but its efficacy is inadequately defined.

Objective: To assess, in a multicenter, retrospective cohort study, the outcomes of SRS for acromegaly and determine predictors.

Methods: We pooled and analyzed data from 10 participating institutions of the International Gamma Knife Research Foundation for patients with acromegaly who underwent SRS with endocrine follow-up of ≥6 mo. Read More

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May 2018
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Acromegaly is associated with high fibroblast growth factor-21 levels.

J Endocrinol Invest 2018 May 12. Epub 2018 May 12.

Division of Endocrinology, Ege University Faculty of Medicine, Ankara Street, Bornova, Izmir, Turkey.

Purpose: Fibroblast growth factor-21 (FGF-21) is a member of fibroblast growth factor family. Both growth hormone (GH) and FGF-21 take place in the regulation of glucose and lipid metabolism. We aimed to investigate FGF-21 levels in acromegaly which is characterized by excess GH levels and is associated with comorbidities and altered body composition. Read More

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Sensitive quantification of the somatostatin analog AP102 in plasma by ultra-high pressure liquid chromatography-tandem mass spectrometry and application to a pharmacokinetic study in rats.

Drug Test Anal 2018 May 10. Epub 2018 May 10.

Service of Clinical Pharmacology, Lausanne University Hospital (CHUV), Switzerland.

AP102 is a di-iodinated octapeptide somatostatin agonist (SSA) designed to treat acromegaly and neuroendocrine tumors. A sensitive and selective method was validated for the quantification of AP102 in plasma following the European Medicines Agency (EMA) and Food and Drug Administration (FDA) guidelines. Sample preparation was performed using solid-phase extraction microplates. Read More

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Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas.

Mol Cell Endocrinol 2018 May 3. Epub 2018 May 3.

Centre for Endocrinology of Queen Mary, University of London, London EC1M 6BQ, UK. Electronic address:

Type 4 phosphodiesterases (PDE4s) of the large PDE enzyme superfamily have unique specificity for cAMP and may, therefore, be relevant for somatotroph tumorigenesis. Somatotroph adenomas typically overexpress PDEs probably as part of a compensatory mechanism to reduce cAMP levels. The rat PDE4A5 isoform (human homolog PDE4A4) interacts with the AIP protein, coded by a tumour suppressor gene mutated in a subgroup of familial isolated pituitary adenomas (FIPAs). Read More

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IGF-1 levels may increase paradoxically with dopamine agonist treatment for prolactinomas.

Pituitary 2018 May 4. Epub 2018 May 4.

Institute of Endocrinology, Rabin Medical Center, Beilinson Hospital, 4941492, Petach Tikva, Israel.

Objective: Hyperprolactinemia is common in acromegaly and in these patients, insulin-like growth factor (IGF)-1 level may decrease with dopamine agonist. We report a series of patients with prolactinoma and a paradoxical increase of IGF-1 levels during cabergoline treatment.

Methods: Clinical characteristics and response to treatment of patients with prolactinomas, in whom normal or slightly elevated baseline IGF-1 levels increased with cabergoline. Read More

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Evaluation of the pharyngeal airway using computational fluid dynamics in patients with acromegaly.

Laryngoscope Investig Otolaryngol 2018 Apr 25;3(2):133-138. Epub 2018 Mar 25.

Department of Anesthesiology and Critical Care Medicine Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan.

Objectives: Perioperative airway management may be particularly challenging in patients with acromegaly undergoing trans-sphenoidal pituitary surgery (TSS). Management for airway obstruction is required prior to pituitary surgery to minimize perioperative hypoxia. The purpose of this retrospective study was to evaluate airway obstruction by simulation of computational fluid dynamics (CFD) using computed tomography (CT) images in patients who had undergone TSS. Read More

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Screening for germline and mutations in a set of somatotropinoma patients.

Endocr Connect 2018 May;7(5):645-652

Institute of Biomedicine/PhysiologyBiomedicum Helsinki, University of Helsinki, Helsinki, Finland

Objective: Recently, mutations in , a potassium channel gene usually linked to long QT syndrome, were reported to cause maternally inherited gingival fibromatosis and growth hormone deficiency (GHD). Expression of the mutated KCNQ1 with the auxiliary potassium channel subunit KCNE2 was shown to reduce pituitary hormone secretion in functional experiments. Here, we investigated if germline mutations in and were present in patients with somatotropinomas, which represent a model of growth hormone excess. Read More

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Berardinelli-Seip Congenital Generalised Lipodystrophy.

J Coll Physicians Surg Pak 2018 May;28(5):406-408

Department of Pediatric Gastroenterology and Hepatology, The Children's Hospital and The Institute of Child Health, Lahore.

Berardinelli-Seip congenital lipodystrophy (BSCL) syndrome is a rare genetic disorder caused by dysregulation of glycemic and lipid metabolism. We report five BSCL cases with typical clinical pictures and complications. These, to the best of our knowledge, represent the first case series from Pakistan. Read More

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May 2018
2 Reads

Pituitary Diseases and Bone.

Endocr Rev 2018 Apr 19. Epub 2018 Apr 19.

Chair of Endocrinology, Università Vita-Salute San Raffaele, Milan, Italy.

Neuroendocrinology of bone is a new area of research based on the evidence that pituitary hormones may directly modulate bone remodeling and metabolism. Skeletal fragility associated with high risk of fractures is a common complication of several pituitary diseases such as hypopituitarism, Cushing disease, acromegaly and hyperprolactinemia. As in other forms of secondary osteoporosis, pituitary diseases generally affect bone quality more than bone quantity and fractures may occur even in the presence of normal or low-normal bone mineral density as measured by dual-energy X-ray absorptiometry, making difficult the prediction of fractures in these clinical settings. Read More

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Higher Income and Integration into the Workforce Are the Main Factors Associated with Quality of Life in Acromegalic Patients in Northeastern Brazil.

Int J Endocrinol 2018 27;2018:6135080. Epub 2018 Feb 27.

Graduate Program in Public Health, Department of Public Health, UFMA, São Luís, MA, Brazil.

Objective: To identify the factors associated with quality of life in patients with acromegaly with follow-up at the referral service in neuroendocrinology of the state of Maranhão, northeast Brazil.

Methods: The Acromegaly Quality of Life Questionnaire (Acro-QoL) was used. Factors independently associated with quality of life were identified using multivariate linear regression, with values < 0. Read More

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February 2018

Cystic tumors of the pituitary infundibulum: seminal autopsy specimens (1899 to 1904) that allowed clinical-pathological craniopharyngioma characterization.

Pituitary 2018 Apr 21. Epub 2018 Apr 21.

Department of Pathology and Clinical Bacteriology, Jakob Erdheim Institute, Vienna, Austria.

A heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as "pituitary strumas". Read More

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Endocrine Remission After Pituitary Stereotactic Radiosurgery: Differences in Rates of Response for Matched Cohorts of Cushing Disease and Acromegaly Patients.

Int J Radiat Oncol Biol Phys 2018 Jul 20;101(3):610-617. Epub 2018 Feb 20.

Department of Neurological Surgery, University of Virginia, Charlottesville, Virginia; Department of Radiation Oncology, University of Virginia, Charlottesville, Virginia.

Purpose: To compare and describe the time to endocrine remission and new hypopituitarism among patients with growth hormone (GH) and adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas after radiosurgery, controlling for several known prognostic factors.

Methods And Materials: An institutional review board-approved, institutional retrospective analysis of patients with GH- and ACTH-secreting pituitary adenomas was performed, with matching for patient sex, age at radiosurgery, interval between the last resection and radiosurgery, use of previous radiation therapy, whole sella treatment, suprasellar extension, cavernous sinus invasion, and margin dose. Endocrine remission was defined as a normal serum insulin-like growth factor-1 (GH secreting) or a normal 24-hour urine-free cortisol (ACTH secreting) level without suppressive medications. Read More

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An orphan G-protein-coupled receptor causes human gigantism and/or acromegaly: Molecular biology and clinical correlations.

Best Pract Res Clin Endocrinol Metab 2018 Apr 17;32(2):125-140. Epub 2018 Mar 17.

Section on Endocrinology and Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892-1862, USA. Electronic address:

X-linked acrogigantism (X-LAG) is a recently described form of familial or sporadic pituitary gigantism characterized by very early onset GH and IGF-1 excess, accelerated growth velocity, gigantism and/or acromegaloid features. Germline or somatic microduplications of the Xq26.3 chromosomal region, invariably involving the GPR101 gene, constitute the genetic defect leading to X-LAG. Read More

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April 2018
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Association between radiological parameters and clinical and molecular characteristics in human somatotropinomas.

Sci Rep 2018 Apr 18;8(1):6173. Epub 2018 Apr 18.

Maimonides Institute of Biomedical Research of Cordoba, Córdoba, 14004, Spain.

Acromegaly is a rare but severe disease, originated in 95% of cases by a growth hormone-secreting adenoma (somatotropinoma) in the pituitary. Magnetic resonance imaging (MRI) is a non-invasive technique used for the diagnosis and prognosis of pituitary tumours. The aim of this study was to determine whether the use of T2-weighted signal intensity at MRI could help to improve the characterisation of somatotropinomas, by analysing its relationship with clinical/molecular features. Read More

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Non-adenomatous pituitary tumours mimicking functioning pituitary adenomas.

Br J Neurosurg 2018 Apr 18:1-5. Epub 2018 Apr 18.

b Key Laboratory of Pituitary Adenoma in Guangdong Province, Department of Neurosurgery , First Affiliated Hospital, SunYat-sen University , Guangzhou , China.

Objective: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. Read More

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April 2018
2 Reads

Iran Pituitary Tumor Registry: Description of the Program and Initial Results.

Arch Iran Med 2017 Dec 31;20(12):746-751. Epub 2017 Dec 31.

Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Background: This study was designed to present initial results on clinical presentation, therapeutic modalities, and outcome information of patients with pituitary tumors registered in Iran Pituitary Tumor Registry (IPTR).

Methods: We collected data from a web-based electronic medical records of patients with various pituitary tumors referred to four tertiary care centers in the country. Retrospective analysis was performed on demographic, clinical, and therapeutic information of 298 patients including 51 clinically nonfunctioning adenoma (CNFA), 85 acromegaly, 135 prolactinoma, and 27 Cushing's disease (CD). Read More

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December 2017
2 Reads

Acromegaly and hyperparthyroidism: about a rare association.

Pan Afr Med J 2018 4;29:12. Epub 2018 Jan 4.

Rheumatology Department, Kassab Institute, Manouba, Tunisia.

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January 2018

[Association between diabetic ketoacidosis and acromegaly].

Medicina (B Aires) 2018 ;78(2):131-133

Departamento de Medicina, VI Cátedra de Medicina, Hospital de Clínicas José de San Martin, Universidad de Buenos Aires, Argentina.

Diabetes mellitus occurs in nearly 10% of patients with acromegaly and is secondary to insulin resistance caused by high levels of growth hormone. Diabetes ketoacidosis has been described as a rare complication of acromegaly, resulting from a relative insulin deficiency caused by growth hormone excess. We described the case of a 38 year-old man who presented to the emergency room with a 6-week history of polydipsia, polyuria, polyphagia and weight loss. Read More

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January 2018

Acromegaly: A rare disease?

Authors:
Oscar D Bruno

Medicina (B Aires) 2018 ;78(2):83-85

Fundación de Endocrinología (FUNDAENDO), Buenos Aires, Argentina. E-mail:

Acromegaly is generally considered a benign and uncommon disease. However, some recent data bring support to the idea that it is more frequent than previously thought. Besides, acromegaly can significantly shorten the length of life due to its cardiovascular and metabolic complications. Read More

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January 2018

Criteria for diagnosis and postoperative control of acromegaly, and screening and management of its comorbidities: Expert consensus.

Endocrinol Diabetes Nutr 2018 May 10;65(5):297-305. Epub 2018 Apr 10.

Servicio de Endocrinología y Nutrición, Hospital Universitari Dexeus, Barcelona, España.

Acromegaly is a rare disease with many comorbidities that impair quality of life and limit survival. There are discrepancies in various clinical guidelines regarding diagnosis and postoperative control criteria, as well as screening and optimal management of comorbidities. This expert consensus was aimed at establishing specific recommendations for the Spanish healthcare system. Read More

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May 2018
2 Reads

Cognitive-behavioral therapy improves the quality of life of patients with acromegaly.

Pituitary 2018 Jun;21(3):323-333

SRTVS 701, Edifício Centro Empresarial Brasília, Bloco "C", sala 204, Asa Sul, Brasília, DF, CEP: 70.340-907, Brazil.

Background: The delayed diagnosis, altered body image, and clinical complications associated with acromegaly impair quality of life.

Purpose: To assess the efficacy of the cognitive-behavioral therapy (CBT) technique "Think Healthy" to increase the quality of life of patients with acromegaly.

Methods: This non-randomized clinical trial examined ten patients with acromegaly (nine women and one man; mean age, 55. Read More

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Association of clinical and laboratory parameters with ambulatory arterial stiffness index in acromegaly patients.

Pak J Med Sci 2018 Jan-Feb;34(1):37-42

Alpaslan Kemal Tuzcu, Department of Endocrinology, Medical Faculty, Dicle University, Diyarbakır, Turkey.

Objective: In this study, we determined the relationship between the ambulatory arterial stiffness index (AASI) and clinical and laboratory parameters in patients with acromegaly.

Methods: Sixty-five patients with acromegaly, who visited to Dicle University Medical Faculty Department of Endocrinology (33 females and 32 males), were included in this study. The study control group consisted of 65 subjects. Read More

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April 2018
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Impact of Glucose Metabolism Disorders on IGF-1 Levels in Patients with Acromegaly.

Horm Metab Res 2018 May 11;50(5):408-413. Epub 2018 Apr 11.

Istanbul University, Istanbul Faculty of Medicine, Division of Endocrinology and Metabolism, Istanbul, Turkey.

In this study, we aimed to evaluate the presence of glucose metabolism abnormalities and their impact on IGF-1 levels in patients with acromegaly. Ninety-three patients with acromegaly (n=93; 52 males/41 females) were included in this study. Patients were separated into three groups such as; normal glucose tolerance (n=23, 25%), prediabetes (n=38, 41%), and diabetes mellitus (n=32, 34%). Read More

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May 2018
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Predictors of surgical outcome and early criteria of remission in acromegaly.

Endocrine 2018 Jun 6;60(3):415-422. Epub 2018 Apr 6.

Neuroendocrinology Research Center / Endocrinology Division - Medical School and Hospital Universitário Clementino Fraga Filho - Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Background: Transsphenoidal surgery (TSS) is the cornerstone of acromegaly treatment, however there are no robust predictors of surgical outcome and remission can only be defined three months after surgery.

Purpose: To analyze if biochemical, demographical, radiological, and immunohistochemical characteristics are predictors of surgical remission and investigate if immediate postoperative GH and IGF-I levels can help defining remission earlier.

Methods: Consecutive acromegaly patients submitted to TSS between 2013-2016 were evaluated. Read More

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Craniofacial Manifestations of Systemic Disorders: CT and MR Imaging Findings and Imaging Approach.

Radiographics 2018 May-Jun;38(3):890-911. Epub 2018 Apr 6.

From the Departments of Radiology (V.C.A.A., M.N.C., H.K., A.F., O.S.), Otolaryngology-Head and Neck Surgery (O.S.), and Radiation Oncology (O.S.), Boston University Medical Center, Boston University School of Medicine, 820 Harrison Ave, 3rd Floor, Boston, MA 02118.

Many systemic diseases or conditions can affect the maxillofacial bones; however, they are often overlooked or incidentally found at routine brain or head and neck imaging performed for other reasons. Early identification of some conditions may significantly affect patient care and alter outcomes. Early recognition of nonneoplastic hematologic disorders, such as thalassemia and sickle cell disease, may help initiate earlier treatment and prevent serious complications. Read More

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April 2018
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USE OF ELECTRONIC HEALTH RECORDS TO CHARACTERIZE A RARE DISEASE IN THE USA: TREATMENT, COMORBIDITIES AND FOLLOW-UP TRENDS AMONG PATIENTS WITH A CONFIRMED DIAGNOSIS OF ACROMEGALY.

Endocr Pract 2018 Apr 6. Epub 2018 Apr 6.

Pfizer Inc, Rare Disease Medical Affairs.

Purpose Understanding of acromegaly disease management is hampered in the US by lack of a national registry. We describe medical management in a population with confirmed acromegaly. Methods Inpatient and outpatient Electronic Health Records (EHR) were used to create a database of de-identified patients assigned the Acromegaly and Gigantism ICD-9 code and/or an appropriate pituitary procedure code at one of four regional hospital systems over a 6-11 year period. Read More

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April 2018
4 Reads