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    Effects of environmental pollutants on signaling pathways in rat pituitary GH3 adenoma cells.
    Environ Res 2017 Jul 18;158:660-668. Epub 2017 Jul 18.
    Division of Oncological Endocrinology, Città della Salute e della Scienza University Hospital, I-10126 Turin, Italy; Department of Medical Sciences, University of Turin, I-10126 Turin, Italy. Electronic address:
    An increased rate of acromegaly was reported in industrialized areas, suggesting an involvement of environmental pollutants in the pathogenesis and behavior of GH-secreting pituitary adenomas. Based on these premises, the aim of the study was to evaluate the effects of some widely diffused pollutants (i.e. Read More

    Growth hormone, prolactin, and sexuality.
    J Endocrinol Invest 2012 Sep 22;35(8):782-794. Epub 2014 Mar 22.
    Department of Molecular & Clinical Endocrinology and Oncology, "Federico II" University of Naples, Via S. Pansini 5, 80131, Naples, Italy.
    GH and PRL, although not considered as 'classi cal' sexual hormones, could play a role in the endocrine control of sexual function both in men and women. Physiologically, PRL seems to be involved in the central control of sexual behavior and activity, by modulating mainly the effects of dopaminergic and serotoninergic systems on sexual function. Indeed, circulating PRL levels increase after orgasm and may potentially play a role in the acute regulation of further sexual arousal following orgasm both in men and women. Read More

    Pasireotide: successful treatment of a sparsely granulated tumour in a resistant case of acromegaly.
    Endocrinol Diabetes Metab Case Rep 2017 10;2017. Epub 2017 Jul 10.
    Department of Endocrinology, Royal Hallamshire Hospital, University of Sheffield, SheffieldUK.
    The granulation pattern of somatotroph adenomas is well known to be associated with differing clinical and biochemical characteristics, and it has been shown that sparsely granulated tumours respond poorly to commonly used somatostatin receptor ligands (SRLs). We report a challenging case of acromegaly with a sparsely granulated tumour resistant to multiple modalities of treatment, ultimately achieving biochemical control with pasireotide. A 26-year-old lady presented with classical features of acromegaly, which was confirmed by an oral glucose tolerance test. Read More

    Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study.
    F1000Res 2017 3;6:614. Epub 2017 May 3.
    Department of Medicine, University of California, San Francisco, San Francisco, CA, 94143, USA.
    Background: Growth hormone (GH) is known to affect insulin and glucose metabolism.  Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men. Read More

    Association between ACE and AGT polymorphism and cardiovascular risk in acromegalic patients.
    Pituitary 2017 Jul 15. Epub 2017 Jul 15.
    Department of Medical Genetics, Hacettepe University School of Medicine, Ankara, Turkey.
    Purpose: Whether the renin-angiotensin-aldosterone system plays a role or not in the development of cardiovascular morbidity in acromegaly patients is unknown. The aim of the study was to investigate the association between ACE (I/D) and AGT (M235T) gene polymorphisms and cardiovascular and metabolic disorders in the acromegaly.

    Methods: The study included one hundred and seventeen acromegalic patients (62 F/55 M, age: 50. Read More

    Acromegaly is associated with increased cancer risk: a survey in Italy.
    Endocr Relat Cancer 2017 Jul 14. Epub 2017 Jul 14.
    M Arosio, Department of Clinical Sciences and Community Health, Endocrinology and Diabetology Unit, Fondazione IRCCS Ca` Granda Ospedale Maggiore Policlinico, Milano, Italy.
    It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 +/- 13 years, followed-up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Read More

    Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population.
    Int J Endocrinol 2017 18;2017:6969286. Epub 2017 Jun 18.
    Neuroendocrine Department, Clinic of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia.
    There are only a few published studies related to the population-based etiology of hypopituitarism. New risks for developing hypopituitarism have been recognized in the last 10 years. Aim. Read More

    Recent Progress in the Medical Therapy of Pituitary Tumors.
    Endocrinol Metab (Seoul) 2017 Jun;32(2):162-170
    Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
    Management of pituitary tumors is multidisciplinary, with medical therapy playing an increasingly important role. With the exception of prolactin-secreting tumors, surgery is still considered the first-line treatment for the majority of pituitary adenomas. However, medical/pharmacological therapy plays an important role in controlling hormone-producing pituitary adenomas, especially for patients with acromegaly and Cushing disease (CD). Read More

    Impact of obstructive sleep apnea in transsphenoidal pituitary surgery: An analysis of inpatient data.
    Laryngoscope 2017 Jul 3. Epub 2017 Jul 3.
    Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey.
    Objectives/hypothesis: Although previous studies have reported increased perioperative complications among obstructive sleep apnea (OSA) patients undergoing any surgery requiring general anesthesia, there is a paucity of literature addressing the impact of OSA on postoperative transsphenoidal surgery (TSS) complications. The aim of this study was to analyze postoperative outcomes in transsphenoidal pituitary surgery patients with OSA. Secondarily, we examined patient characteristics and comorbidities. Read More

    The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.
    Clin Proteomics 2017 29;14:24. Epub 2017 Jun 29.
    Edison Biotechnology Institute, Ohio University, Athens, OH USA.
    Growth hormone (GH) is a protein that is known to stimulate postnatal growth, counter regulate insulin's action and induce expression of insulin-like growth factor-1. GH exerts anabolic or catabolic effects depending upon on the targeted tissue. For instance, GH increases skeletal muscle and decreases adipose tissue mass. Read More

    Insulin resistance in endocrine disorders - treatment options.
    Endokrynol Pol 2017 ;68(3):334-351
    Department of Internal Medicine and Diabetology, Poznan University of Medical Science, Poland.
    Changes in sensitivity to insulin occur in the course of a number of endocrine disorders. Most of the hormones through their antagonistic action to insulin lead to increased hepatic glucose output and its decreased utilisation in peripheral tissues. Carbohydrate disorders observed in endocrine diseases result from the phenomenon of insulin resistance, and in some cases also a reduction in insulin secretion is present. Read More

    Evaluation of depressive mood and cognitive functions in patients with acromegaly under somatostatin analogue therapy.
    J Endocrinol Invest 2017 Jun 28. Epub 2017 Jun 28.
    T.C. Saglik Bakanligi Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi, İc hastalıklari ABD, Endokrinoloji ve Metabolizma BD, Fevzi Cakmak Mah. Muhsin Yazicioglu Cad. No: 10, Pendik, PK: 34899, Istanbul, Turkey.
    Aims: Acromegaly is caused by a pituitary adenoma that releases excess growth hormone (GH) and a concomitant increase in insulin-like growth factor 1 (IGF-1). Acromegaly results not only in phenotypic changes, but also in neurologic complications as peripheral neuropathy and cognitive dysfunction. This study aimed to compare depressive mood and cognitive function in patients with acromegaly and in healthy controls as well as to determine the factors underlying cognitive dysfunction in the acromegalic patients. Read More

    [Acromegaly and Cushing's disease: Persistence of comorbidities after the control of hypersecretion].
    Ann Endocrinol (Paris) 2016 Oct;77 Suppl 1:S19-S28
    Université d'Aix-Marseille, Jardin du Pharo, 58 Boulevard Charles Livon, 13284 Marseille, France; Service d'endocrinologie-diabète-maladies métaboliques, Pôle ENDO, Centre de Référence Pathologies hypophysaires Rares, Hôpital de la Conception, 147 Boulevard Baille, 13005 Marseille, France; Faculté de Médecine Secteur Nord, CNRS UMR 7286 - CRN2M, Boulevard Pierre Dramard, 13015 Marseille, France. Electronic address:
    Acromegaly and Cushing's disease lead to common and distinct comorbidities. Currently available treatments lead to the control of hyper secretion in the majority of cases. However, the prevalence of the comorbidities does not always go back to the one of the normal population after remission. Read More

    Acromegaly discovered during a routine out-patient surgical procedure: a case report.
    J Med Case Rep 2017 Jun 24;11(1):169. Epub 2017 Jun 24.
    Department of Anesthesiology, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32608, USA.
    Background: Acromegaly is a rare syndrome in which there is unregulated hypersecretion of growth hormone. The anesthetic management of patients with this disorder is particularly challenging due to pre-existing cardiovascular and respiratory dysfunction, as well as recognized difficulties with airway management. Because of the insidious progression of the disease and the presence of nonspecific signs and symptoms, diagnosis is often made late when characteristic acromegalic features become apparent. Read More

    [Diabetes mellitus secondary to an endocrine pathology : when to think about it ?]
    Rev Med Suisse 2017 May;13(565):1158-1162
    Service d'endocrinologie, diabétologie, hypertension et nutrition, HUG, 1211 Genève 14.
    An endocrine disease can be associated with glucose intolerance or diabetes mellitus, and the latter can falsely be considered as type 2 diabetes. Glycemic imbalance can be a direct or indirect consequence of excessive hormone production. Endocrine diseases such as acromegaly, Cushing's syndrome and pheochromocytoma can increase glucose production and cause insulin resistance. Read More

    How does pregnancy affect the patients with pituitary adenomas: a study on 113 pregnancies from Turkey.
    J Endocrinol Invest 2017 Jun 20. Epub 2017 Jun 20.
    Department of Endocrinology, Erciyes University Medical School, 38039, Kayseri, Turkey.
    Objective: Data regarding pregnancies in relation to pituitary tumors are limited. The effects of pregnancy on pituitary adenomas and the effects of adenoma itself (hormonal activity, mass effects and pituitary insufficiency) and/or treatment on the ongoing gestation and developing fetus were evaluated.

    Methods: The study was a retrospective study. Read More

    In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.
    Eur J Endocrinol 2017 Sep 20;177(3):257-266. Epub 2017 Jun 20.
    William Harvey Research InstituteBarts and the London School of Medicine, Queen Mary University of London, London, UK
    Objective: Mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are associated with pituitary adenoma, acromegaly and gigantism. Identical alleles in unrelated pedigrees could be inherited from a common ancestor or result from recurrent mutation events.

    Design And Methods: Observational, inferential and experimental study, including: AIP mutation testing; reconstruction of 14 AIP-region (8. Read More

    Tumour-Derived Human Growth Hormone As a Therapeutic Target in Oncology.
    Trends Endocrinol Metab 2017 Aug 13;28(8):587-596. Epub 2017 Jun 13.
    Cancer Science Institute of Singapore and Department of Pharmacology, National University of Singapore, 117456 Singapore; Tsinghua Berkeley Shenzhen Institute, Tsinghua University Graduate School, Shenzhen, PR China. Electronic address:
    The growth hormone (GH) and insulin-like growth factor-1 (IGF1) axis is the key regulator of longitudinal growth, promoting postnatal bone and muscle growth. The available data suggest that GH expression by tumour cells is associated with the aetiology and progression of various cancers such as endometrial, breast, liver, prostate, and colon cancer. Accordingly there has been increased interest in targeting GH-mediated signal transduction in a therapeutic setting. Read More

    High levels of IGF-1 predict difficult intubation of patients with acromegaly.
    Endocrine 2017 Aug 15;57(2):326-334. Epub 2017 Jun 15.
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, People's Republic of China.
    Purpose: To investigate the characteristics of difficult intubation and identify novel efficient predictors in patients with acromegaly.

    Methods: Patients with either untreated acromegaly or non-functional pituitary adenomas were enrolled. Patients with acromegaly underwent hormone assays, upper airway computed tomography and magnetic resonance imaging examinations and preoperative overnight polysomnography. Read More

    Growth hormone and insulin-like growth factor 1 affect the severity of Graves' disease.
    Endocrinol Diabetes Metab Case Rep 2017 7;2017. Epub 2017 Jun 7.
    Department of Medical, Oral and Biotechnological Sciences, Dental School, University 'G. d'Annunzio' of Chieti-Pescara, ChietiItaly.
    Graves' disease, the most common form of hyperthyroidism in iodine-replete countries, is associated with the presence of immunoglobulins G (IgGs) that are responsible for thyroid growth and hyperfunction. In this article, we report the unusual case of a patient with acromegaly and a severe form of Graves' disease. Here, we address the issue concerning the role of growth hormone (GH) and insulin-like growth factor 1 (IGF1) in influencing thyroid function. Read More

    [Association of GH and IGF-1 Burden with Cardiac Structural and Functional Changes in Acromegaly Patients].
    Sichuan Da Xue Xue Bao Yi Xue Ban 2017 May;48(3):431-434
    Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100730, China.
    Objectives: To investigate the association of growth hormone (GH) and insulin-like growth factor (IGF-1) burden with the cardiac structural and functional changes in acromegaly patients.

    Methods: Ninety-nine acromegaly patients were enrolled in this study. According to the normal range of echocardiographic parameters of Peking Union Medical College Hospital, the patients were divided into parameter normal group and abnormal group. Read More

    IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK.
    J Mol Endocrinol 2017 Aug 13;59(2):129-139. Epub 2017 Jun 13.
    Department of Internal MedicineRadboud University Medical Center, Nijmegen, The Netherlands
    Acromegaly is characterized by growth hormone (GH) and insulin-like growth factor 1 (IGF1) excess and is accompanied by an increased cardiovascular diseases (CVD) risk. As innate immune responses are crucial in CVD development, and IGF1 is linked to subclinical inflammation, we hypothesized that GH/IGF1 excess contributes to CVD development by potentiating systemic inflammation. We aimed to assess the effects of GH/IGF1 on inflammatory cytokine production. Read More

    Recurrent Kidney Stone Episodes Leading to a Diagnosis of Occult Acromegaly.
    Urol Case Rep 2017 Sep 3;14:8-10. Epub 2017 Jun 3.
    Department of Urology, Icahn School of Medicine at Mount Sinai 425 W. 59th Street, Suite 4F, New York, NY 10019, USA.
    The association between nephrolithiasis and acromegaly has been previously described. Although the mechanism has been established, the urological literature sparsely discusses clinically suspecting that patients with recurrent nephrolithiasis could have acromegaly and subsequently referring them for accurate diagnosis and treatment. We present a case of occult acromegaly secondary to a pituitary tumor discovered 20 years after the patient's first stone episode. Read More

    Pachydermoperiostosis of the complete type: A novel missense mutation c.101T > C in the SLCO2A1 gene.
    Eur J Med Genet 2017 Aug 8;60(8):433-436. Epub 2017 Jun 8.
    Department of Endocrinology, The First Central Hospital(BDCH), Baoding 071000, China. Electronic address:
    We report on a rare case of pachydermoperiostosis (PDP) in a 25-year-old male who was admitted to our hospital because of enlargement of fingers and toes. Through examination, we found some typical features on the patient including finger clubbing, periostosis, pachydermia, and cutis verticis gyrata (CVG). But laboratory tests were almost within normal ranges, which ruled out rheumatic arthritis, osteopulmonary arthropathy, thyroid acropathy, and acromegaly. Read More

    Intraoperative scoring system to predict postoperative remission in endoscopic endonasal transsphenoidal surgery for growth hormone-secreting pituitary adenomas.
    World Neurosurg 2017 Jun 5. Epub 2017 Jun 5.
    Department of Neurosurgery, Faculty of Life Sciences, Kumamoto University Graduate School.
    Objective: This study aimed to determine the predictive factors for endocrinological remission of patients with growth hormone (GH)-secreting pituitary adenomas.

    Methods: In 47 patients with GH-secreting pituitary adenomas who underwent endoscopic endonasal transsphenoidal surgery with intraoperative GH measurements from 2002 to 2011, the relationship between the intraoperative GH levels and postoperative remission was analyzed, and two items that predicted remission (GH half-life obtained 30 min or less after removal and a minimum surgical GH level less than 2.5 ng/mL) were determined. Read More

    Efficacy and safety of long-acting pasireotide in Japanese patients with acromegaly or pituitary gigantism: results from a multicenter, open-label, randomized, phase 2 study.
    Endocr J 2017 Jun 8. Epub 2017 Jun 8.
    Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto 612-8555, Japan.
    A multicenter, open-label, phase 2 study was conducted to investigate the efficacy and safety of long-acting pasireotide formulation in Japanese patients with acromegaly or pituitary gigantism. Medically naïve or inadequately controlled patients (on somatostatin analogues or dopamine agonists) were included. Primary end point was the proportion of all patients who achieved biochemical control (mean growth hormone [GH] levels<2. Read More

    Long term follow-up of growth hormone-secreting pituitary adenomas submitted to endoscopic endonasal surgery.
    Arq Neuropsiquiatr 2017 May;75(5):301-306
    Faculdade de Ciências Médicas, Santa Casa de São Paulo, Departamento de Otorrinolaringologia São Paulo SP, Brasil.
    Objective: The aim of this study was to evaluate the results of the endoscopic transsphenoidal technique for growth hormone (GH)-secreting adenomas.

    Methods: A retrospective analysis based on medical records of 23 acromegalic patients submitted to endoscopic transsphenoidal surgery. Biochemical control was defined as basal GH < 1ng/ml, nadir GH < 0. Read More

    Acromegaly: surgical results in 548 patients.
    Pituitary 2017 Jun 6. Epub 2017 Jun 6.
    Neurosurgery Department, Puerta de Hierro Hospital, Madrid, Spain.
    Purpose: The goal of this study was to quantified the results of microsurgery, in all the patients with acromegaly treated by the same endocrinologist and the same surgeon between 1975 and 2015.

    Methods: A series of 548 patients with acromegaly were operated and followed-up from 6 months to 40 years. Patients were selected according to five criteria: (1) Operated by the same surgeon. Read More

    Effects of anti-somatostatin agents on glucose metabolism.
    Diabetes Metab 2017 Jun 1. Epub 2017 Jun 1.
    Service d'endocrinologie, diabétologie et maladies métaboliques, hôpital du Bocage, CHU de Dijon, 21000 Dijon, France; Inserm LNC, UMR1231, 21000 Dijon, France. Electronic address:
    The anti-somatostatin agents used to treat acromegaly, Cushing's disease and neuroendocrine tumours also have hyperglycaemic effects. This is particularly true for pasireotide. Hyperglycaemic events are seen in 57-73% of patients with Cushing's treated with pasireotide, with a need to initiate antidiabetic treatment in about 50% of these patients. Read More

    Pasireotide in an insulin-requiring diabetic acromegalic patient without worsening of hyperglycemia.
    Endocrinol Diabetes Metab Case Rep 2017 13;2017. Epub 2017 May 13.
    Allegheny Neuroendocrinology Center, Departments of Medicine and Neurosurgery, Allegheny General Hospital, Pittsburgh, PennsylvaniaUSA.
    Long-acting pasireotide is an effective treatment option for acromegaly, but it is associated with hyperglycemia, which could impact its use in patients with diabetes. We present a case of a 53-year-old man with acromegaly and type 2 diabetes mellitus (glycated hemoglobin (HbA1c): 7.5%), who refused surgery to remove a pituitary macroadenoma and enrolled in a Phase 3 clinical trial comparing long-acting pasireotide and long-acting octreotide in acromegalic patients. Read More

    Stubborn hiccups as a sign of massive apoplexy in a naive acromegaly patient with pituitary macroadenoma.
    Endocrinol Diabetes Metab Case Rep 2017 18;2017. Epub 2017 May 18.
    Departments of Endocrinology.
    Pituitary apoplexy (PA) may very rarely present with hiccups. A 32-year-old man with classical acromegaloid features was admitted with headache, nausea, vomiting and stubborn hiccups. Pituitary magnetic resonance imaging (MRI) demonstrated apoplexy of a macroadenoma with suprasellar extension abutting the optic chiasm. Read More

    Pachydermoperiostosis: a rare mimicker of acromegaly.
    Endocrinol Diabetes Metab Case Rep 2017 16;2017. Epub 2017 May 16.
    Endocrinology Unit, Department of Medicine, Putrajaya Hospital, PutrajayaMalaysia.
    Pachydermoperiostosis is a very rare osteoarthrodermopathic disorder whose clinical and radiographic presentations may mimic those of acromegaly. In the evaluation of patients with acromegaloid appearances, pachydermoperiostosis should be considered as a differential diagnosis. In this article, we report a 17-year-old boy who presented with 2-year history of acral enlargement and facial appearance changes associated with joint pain and excessive sweating. Read More

    Muscle strength in patients with acromegaly at diagnosis and during long-term follow-up.
    Eur J Endocrinol 2017 Aug 31;177(2):217-226. Epub 2017 May 31.
    Department of Internal Medicine and Clinical NutritionInstitute of Medicine, Sahlgrenska Academy, University of Gothenburg and Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Objective: Patients with acromegaly have decreased body fat (BF) and increased extracellular water (ECW) and muscle mass. Although there is a lack of systematic studies on muscle function, it is believed that patients with acromegaly may suffer from proximal muscle weakness despite their increased muscle mass. We studied body composition and muscle function in untreated acromegaly and after biochemical remission. Read More

    Anti-tumoral effects of somatostatin analogs: a lesson from the CLARINET study.
    J Endocrinol Invest 2017 May 26. Epub 2017 May 26.
    Endocrinology Unit, Department of Internal Medicine (DiMI), University of Genova, Genoa, Italy.
    Octreotide and lanreotide, the first-generation somatostatin analogs, successfully control hormone hyperproduction, and related syndromes, in patients with acromegaly and neuroendocrine tumors. However, their anti-tumor effect, rather evident in large number of pituitary adenomas in acromegalic patients, has been hypothesized for a long time in patients with neuroendocrine tumors as well, although a significant tumor shrinkage has rarely been observed. However, the recent publication of the CLARINET study has strengthened the evidence, already emerged with the PROMID trial, that the long-term treatment with the first-generation long-acting somatostatin analogs may exert an anti-tumor activity on G1 and G2 enteropancreatic neuroendocrine tumors, as well. Read More

    Cross-sectional prevalence of pancreatic cystic lesions in patients with acromegaly, a single-center experience.
    Pituitary 2017 May 24. Epub 2017 May 24.
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
    Purpose: Acromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported that GNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study. Read More

    Prescription patterns of long-acting somatostatin analogues.
    SAGE Open Med 2017 9;5:2050312117694795. Epub 2017 Mar 9.
    Grupo de Investigación en Farmacoepidemiología y Farmacovigilancia, Universidad Tecnológica de Pereira-Audifarma S.A., Pereira, Colombia.
    Background: Acromegaly and endocrine tumors are uncommon morbidities that are currently treated with different drugs.

    Objective: To determine the prescription patterns of somatostatin analogues in patients affiliated with the Health System of Colombia.

    Methods: Retrospective cohort study of patients of any age and sex treated with octreotide or lanreotide between January 2011 and August 2015. Read More

    Standardization of Growth Hormone and Insulin-like Growth Factor-I Measurements.
    Pediatr Endocrinol Rev 2017 Mar;14(Suppl 1):209-215
    Department of Molecular Endocrinology, National Research Institute for Child Health and Development 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan.
    Measurement of the levels of growth hormone (GH) and its related factor insulin-like growth factor I (IGF-I) is essential for the diagnosis and treatment of GH deficiency (GHD) and conditions related to excess GH such as acromegaly and pituitary gigantism. Measurement of GH levels is also used as an indicator of hypothalamic-pituitary function. Because of the marked variability in GH measurements among kits, the Study Committee for GH and Its Related Factors of The Foundation for Growth Science, Japan standardized GH values measured with various commercially available GH assay kits in Japan. Read More

    The Longevity Hormone Klotho is a New Player in the Interacion of the Growth Hormone/Insulin-Like Growth Factor 1 Axis.
    Pediatr Endocrinol Rev 2016 Sep;14(1):9-18
    Pediatric Endocrinology and Diabetes unit, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Klotho was first discovered as an aging-suppressor gene. Mice that do not express klotho die prematurely with multiple symptoms of aging, several of which are also characteristic of decreased GH/IGF-1 axis activity. Klotho is highly expressed in the brain, the kidney, and parathyroid and pituitary glands, but can also serve as a circulating hormone by its shedding, forming soluble klotho (sKlotho) that can be detected in blood, cerebrospinal fluid and urine. Read More

    Evaluation of macular and peripapillary choroidal thickness, macular volume and retinal nerve fiber layer in acromegaly patients.
    Int Ophthalmol 2017 May 15. Epub 2017 May 15.
    Department of Ophthalmology, Medical Faculty, Bulent Ecevit University, Zonguldak, Turkey.
    Purpose: To evaluate macular volume, retinal nerve fiber layer, and macular and peripapillary choroidal thickness in acromegaly patients.

    Method: In this prospective, case-control study, 31 patients with acromegaly and 32 healthy subjects were recruited. Only right eyes were evaluated. Read More

    Classification of patients with GH disorders may vary according to the IGF-I assay.
    J Clin Endocrinol Metab 2017 May 12. Epub 2017 May 12.
    Service d'Endocrinologie et des Maladies de la Reproduction and Centre de Référence des Maladies Endocriniennes Rares de la Croissance (M.M., E.K., J.Y., P.C.), Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Hôpital de Bicêtre, Unité de Recherche Clinique (H.A, A.A.), and Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie (S.B-T.), Le Kremlin-Bicêtre, F94275, France; Inserm 1185 (E.K., S.B-T., J.Y., P.C.), Fac Med Paris Sud, Université Paris-Saclay, Le Kremlin-Bicêtre, F-94276, France; and Laboratoire d'Hormonologie (C.M.), Centre Hospitalier Universitaire de Rennes, Centre d'Investigation Clinique Plurithématique, Inserm 1414, Hôpital Pontchaillou, Rennes, F29000, France; Service des Explorations Fonctionnelles (M-L.P., J.-C.S.), Assistance Publique-Hôpitaux de Paris, Hôpital Necker-Enfants Malades, Paris, F75015, France.
    Context: IGF-I measurement is essential for the diagnosis and management of GH disorders. However, patient classification may vary substantially according to the assay technique.

    Objective: We compared individual patient data and classifications obtained with six different IGF-I assay kits in a group of patients with various GH disorders. Read More

    Somatotropinomas inadequately controlled with octreotide may over-respond to pasireotide: the importance of dose adjustment to achieve long-term biochemical control.
    Hormones (Athens) 2017 Jan;16(1):84-91
    Department of Internal Medicine and Endocrine Unit, Medical School and Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Objective: To present two female patients with acromegaly inadequately controlled with long-acting octreotide who were subsequently treated with the multireceptor-targeted somatostatin analogue pasireotide that over-suppressed IGF-1 levels.

    Methods: We report two patients who failed surgery and received long-acting octreotide 20-30 mg/month as part of two double-blind, Phase III clinical trials. After 6-12 months of octreotide treatment, both patients remained inadequately controlled and were switched to long-acting pasireotide 40 mg/month as part of a crossover extension phase. Read More

    Treatment of acromegaly patients at the Federal University of Triângulo Mineiro (UFTM): Experience Report.
    Clinics (Sao Paulo) 2017 Apr;72(4):218-223
    Divisão de Endocrinologia e Metabolismo, Universidade Federal do Triângulo Mineiro, Uberaba, MG, BR.
    Objective:: To evaluate the effectiveness of the treatment of acromegaly patients at the Federal University of Triangulo Mineiro.

    Methods:: Cross-sectional and retrospective study of thirty cases treated over a period of two decades.

    Results:: 17 men (56. Read More

    Acromegaly in a non-diabetic cat.
    JFMS Open Rep 2016 Jan-Jun;2(1):2055116916646585. Epub 2016 Apr 25.
    Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
    Case Summary: A 14-year-old, neutered male European shorthair cat was evaluated for a routine health check. The owner did not report any clinical signs except for respiratory stridor. On physical examination the main findings were broad facial features and increased interdental spaces. Read More

    GH-secreting pituitary macroadenoma (acromegaly) associated with progressive dental malocclusion and refractory CPAP treatment.
    Head Face Med 2017 May 10;13(1). Epub 2017 May 10.
    Chief of Oral and Maxillofacial Department, Hospital Universitari Mútua de Terrassa, Universitat de Barcelona, Terrassa, Spain.
    Background: A link between progressive dental malocclusion, the use of a continuous positive airway pressure mask and GH-secreting pituitary macroadenoma (acromegaly) has not been previously reported. The present clinicopathological analysis stresses that tooth malposition should not be seen exclusively as a local process.

    Case Presentation: A 62-year-old caucasian man with no relevant medical history reported difficulty chewing food and perceived voice alteration during his annual periodontal check-up. Read More

    Octreotide-Associated Neutropenia.
    Pharmacotherapy 2017 Jun;37(6):e32-e37
    Department of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York.
    Drug-induced neutropenia and agranulocytosis are rare adverse events but can be fatal. Neutropenia can be induced by a myriad of drugs from almost every pharmacologic class. Octreotide is a somatostatin analog that has been used to treat variceal bleeding, acromegaly, and severe diarrhea associated with metastatic tumors, and to reduce symptoms in the setting of malignant bowel obstruction and pseudoobstruction. Read More

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