77 results match your criteria Acrokeratoelastoidosis
J Cutan Pathol 2018 Oct 7. Epub 2018 Oct 7.
Department of Dermatology, University of Florida College of Medicine, Gainesville, Florida.
Collagenous and elastotic marginal plaques of the hand (CEMPH) is a rare, chronic keratoderma characterized by hyperkeratotic linear plaques located along the radial and ulnar aspects of the hands bilaterally. As an isolated finding, CEMPH occurs secondarily to chronic trauma and photodamage. Herein, CEMPH is described as a manifestation of alkaptonuria (AKU). Read More
Clin Exp Dermatol 2019 01 16;44(1):88-91. Epub 2018 Sep 16.
Department of Dermatology, Peking University First Hospital, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, 100034, China.
Clin Exp Dermatol 2018 Oct 14;43(7):819-820. Epub 2018 May 14.
Department of Dermatology, No. 1 Affiliated hospital and Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, China.
J Am Podiatr Med Assoc 2018 Mar;108(2):178-181
Acrokeratoelastoidosis (AKE) is a rare form of focal acral keratoderma of unknown cause that typically begins during childhood and manifests with multiple, small, hyperkeratotic papules located over the lateral margins of the hands and feet. The purpose of this article is to report a pediatric case of AKE with dermoscopic, sonographic, and histopathologic descriptions, contributing to the awareness of this clinical diagnosis. We describe a 7-year-old girl with nonpainful yellowish papules on the lateral and medial aspects of both feet. Read More
JAAD Case Rep 2018 Jan 19;4(1):75-76. Epub 2017 Dec 19.
Department of Medicine, Section of Dermatology, University of Chicago, Chicago, Illinois.
J Eur Acad Dermatol Venereol 2018 May 28;32(5):e165-e167. Epub 2017 Nov 28.
EMBRAPA-CPA-CT, Pelotas, Brazil.
Br J Dermatol 2017 10;177(4):e157
Department of Dermatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, Japan, 466-8560.
Cutis 2017 02;99(2):E7-E8
Department of Dermatology, Kaiser Permanente Los Angeles Medical Center, USA.
Actas Dermosifiliogr 2017 Jul - Aug;108(6):579-580. Epub 2016 Oct 7.
Servicio de Dermatología, Hospital Universitario Donostia, Donostia-San Sebastián, Guipúzcoa, España.
J Dermatol 2017 Mar 4;44(3):e46-e47. Epub 2016 Jul 4.
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Presse Med 2016 Jun 12;45(6 Pt 1):607-8. Epub 2016 May 12.
CHU Ibn Sina, université Mohammed V, faculté de médecine et de pharmacie, service de dermatologie-vénérologie, Rabat, Maroc.
Indian Dermatol Online J 2015 Nov-Dec;6(6):460-1
Department of Dermatology, Seth GS Medical College, King Edward Memorial Hospital, Mumbai, Maharashtra, India.
Ann Dermatol Venereol 2015 Mar 23;142(3):170-5. Epub 2015 Jan 23.
Service de dermatologie, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:
Background: Ainhum, or spontaneous dactylitis, involves the formation of a gradual constriction in the digital-plantar fold of the fifth toe that leads, after several years, to autoamputation of the digit. This condition is classically distinguished from "true" ainhum, of unknown aetiology and affecting only subjects of African origin, from "pseudo-ainhum", resulting from different causes such as inflammatory constriction or constriction by a foreign body, and finally from ainhumoid palmoplantar keratoderma, which is of genetic origin and occurs for instance in Vohwinkel syndrome. Herein, we report three cases of ainhum in women of sub-Saharan African origin; in addition, all three subjects were also presenting various forms of hyperkeratosis of the hands and feet known to primarily affect subjects of African origin. Read More
Dermatol Online J 2015 Dec 16;21(12). Epub 2015 Dec 16.
New York University School of Medicine.
Acrokeratoelastoidosis is a rare palmoplantar keratoderma. We report the case of a 32-year old man with multiple keratotic papules and plaques on the peripheral margins of his hands and feet. Histopathologic evaluation showed compact orthokeratosis; Verhoeff van Gieson stain showed thin and fragmented elastic fibers. Read More
An Bras Dermatol 2014 Sep-Oct;89(5):835-6
Padre Bento of Guarulhos Hospital Complex, Guarulhos, SP, Brazil.
Focal acral hyperkeratosis is a rare genodermatosis with an autosomal dominant pattern of inheritance. It is characterized by usually asymptomatic keratotic papules along the borders of the hands and/or feet. The main differential diagnosis is acrokeratoelastoidosis of Costa, which differs from the former only by not presenting elastorrhexis in histopathological examination, thus requiring this exam for a correct diagnosis. Read More
Cutis 2014 Aug;94(2):E1-2
Department of Dermatology, The Eastern Hospital of the First Affiliated Hospital, Sun Yat-sen University, 183 Huangpu Rd E, Guangzhou 510700, China.
Eur J Dermatol 2014 Jul-Aug;24(4):516-7
Department of Dermatology, Carlos Haya Regional University Hospital. Pza Hospital Civil s/n, 29009 Malaga, Spain.
J Med Case Rep 2014 May 8;8:143. Epub 2014 May 8.
College of Medicine, King Saud University, P,O, BOX 50652, Riyadh 11533, Saudi Arabia.
Introduction: Acrokeratoelastoidosis is a rare condition characterized by bilateral multiple hyperkeratotic papules on the palms, soles, and dorsum of the hands and feet. To the best of our knowledge, only around 40 cases of acrokeratoelastoidosis have been reported worldwide, which are mostly familial.
Case Presentation: We report the first case from Saudi Arabia in a 5-year-old Saudi girl of Arabian origin, who presented symptoms of acrokeratoelastoidosis with unilateral sporadic keratosis on her left hand and left foot. Read More
Clin Exp Dermatol 2014 Jul 8;39(5):671-2. Epub 2014 Apr 8.
Department of Dermatology, CHD Vendée, La Roche-sur-Yon, France.
Indian J Dermatol 2012 Sep;57(5):343-52
Department of Dermatology, STD and Leprosy, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
Background: Skin is a window to aging changes, a biological reality. There is a dearth of studies regarding the various chronological (intrinsic) aging and photoaging (extrinsic) changes seen in Asians. This study was undertaken to detect the clinical pattern of aging skin changes and dermatoses seen in the elderly. Read More
An Bras Dermatol 2011 Nov-Dec;86(6):1222-3
Prof. Rubem David Azulay Institute of Dermatology, Santa Casa de Misericórdia do Rio de Janeiro, Brazil.
Acrokeratoelastoidosis is a type of palmoplantar keratoderma first described by Oswaldo Gonçalves Costa, a Brazilian Dermatologist from the state of Minas Gerais. It is a rare autosomal-dominant genodermatosis; however it may occur sporadically. The disease is not congenital; rather, its onset occurs in childhood or adolescence. Read More
Indian J Dermatol Venereol Leprol 2011 Mar-Apr;77(2):249-50
Department of Dermatology, PD Hinduja Hospital and MRC, Veer Savarkar Marg, Mahim, Mumbai-400 016, India.
Pediatr Dermatol 2011 Jan-Feb;28(1):20-2. Epub 2011 Jan 5.
Department of Emergency Medicine, Northwestern University, Chicago, Illinois, USA.
Acrokeratoelastoidosis (AKE) is a rare disease that manifests as wartlike papules along the dorsal palmar junction. It is characterized by orthohyperkeratosis in the horny layer and elastorrhexis in the reticular dermis. Both sporadic and familial cases following autosomal dominant inheritance have been reported. Read More
J Clin Aesthet Dermatol 2010 Jun;3(6):51-3
Acrokeratoelastoidosis of Oswaldo Costa, or inverse papular acrokeratosis, is a rare genodermatosis first described in 1952 by Oswaldo Costa, a Brazilian dermatologist. It is characterized by flesh-colored papules on the lateral aspects of the palms and soles and dorsum of hands. The histological features are hyperkeratosis, hyalinized and homogenous collagen, and a decrease in and fragmentation of the elastic fibers (elastorrhexis). Read More
Ann Dermatol 2009 Nov 30;21(4):426-8. Epub 2009 Nov 30.
Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Focal acral hyperkeratosis (FAH) is a rare genodermatosis with an autosomal dominant pattern of inheritance; however, it may also be sporadic. FAH is characterized by late-onset crateriform keratotic papules, some coalescing into plaques, along the borders of the hands and feet. We herein report a case of FAH in a 47-year-old male with a family history of similar lesions in three generations. Read More
J Eur Acad Dermatol Venereol 2009 Sep 11;23(9):1113-4. Epub 2009 Mar 11.
Dermatol Online J 2008 Sep 15;14(9):11. Epub 2008 Sep 15.
Department of Dermatology, Ibn Sina Hospital, Rabat, Morocco.
Acrokeratoelastoidosis (AKE) is a rare skin disorder characterized by a papular eruption and fragmentation of elastic tissue that primarily involves the margins of the hands and feet. The most common histopathologic findings of AKE are hyperkeratosis and degeneration of elastic fibers. Various treatment options have been tried with little help or without success. Read More
Int J Dermatol 2008 Aug;47(8):873-5
Clin Exp Dermatol 2008 Jan 3;33(1):30-1. Epub 2007 Nov 3.
Department of Dermatology, Gulhane Military School of Medicine, Ankara, Turkey.
Acrokeratoelastoidosis is a rare skin disorder characterized by grouped, small, firm, translucent papules distributed on the margins of the hands and feet. We report a 21-year-old white patient with acrokeratoelastoidosis in whom Er:YAG laser surgery was carried out, resulting in a slight post-treatment improvement of the disease with slight flattening of the lesions. No clinical recurrence of the lesions developed during the 6 months of follow-up. Read More
Arch Dermatol 2006 Jul;142(7):939-41
Eur J Dermatol 2006 Mar-Apr;16(2):201-2
Actas Dermosifiliogr 2005 Jan-Feb;96(1):37-9
Dermatóloga, Centro Dermatológico Dr. Ladislao de Pascua (CDP), Ciudad de México.
Focal acral hyperkeratosis is characterized by the same clinical appearance as acrokeratoelastoidosis, but without abnormalities in the elastic fibers. We present the case of a woman with a 10-year case of dermatosis localized on the palms, soles and dorsum of the metacarpophalangeal joints, consisting of multiple polygonal papules and associated hyperhydrosis, clinically compatible with acrokeratoelastoidosis. Her father had a history of the disease. Read More
Int J Dermatol 2005 May;44(5):406-7
Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, 2330 Butler Suite 115, Dallas, TX 75235, USA.
A 45-year-old white woman presented with several years' history of firm, shiny papules on the lateral hands with slight extension to the dorsal fingers. The lesions first appeared between the index fingers and thumbs on both hands. They gradually increased in number, coalescing into plaques and affecting the junction between the palmar and dorsal skin. Read More
J Am Acad Dermatol 2004 Aug;51(2):165-85; quiz 186-8
Department of Dermatology, Brown Medical School-Rhode Island Hospital, Providence, RI 02903, USA.
Elastic fibers in the extracellular matrix are integral components of dermal connective tissue. The resilience and elasticity required for normal structure and function of the skin are attributable to the network of elastic tissue. Advances in our understanding of elastic tissue physiology provide a foundation for studying the pathogenesis of elastic tissue disorders. Read More
Pediatr Dermatol 2004 Mar-Apr;21(2):128-30
Department of Dermatology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
Acrokeratoelastoidosis and focal acral hyperkeratosis share similar clinical features and identical histologic epidermal alterations. These disorders are distinguished solely on the basis of the absence of elastorrhexis in the latter. We present a case of focal acral hyperkeratosis in a 9-year-old girl. Read More
Eur J Dermatol 2003 Sep-Oct;13(5):490-2
Department of Dermatology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.
We report a case of acrokeratoelastoidosis associated with nodular scleroderma, a variant of localized scleroderma. The patient showed no clinical and laboratory signs of systemic scleroderma. Because there is a paper describing the association of acrokeratoelastoidosis with systemic scleroderma, coexistence of acrokeratoelastoidosis and nodular scleroderma in the patient suggests that acrokeratoelastoidosis is related to localized nodular scleroderma as well as systemic scleroderma. Read More
Pediatr Dermatol 2002 Jul-Aug;19(4):320-2
St. Louis University School of Medicine and Department of Dermatology, Saint Louis University Health Sciences Center, St. Louis, Missouri 63104, USA.
Acrokeratoelastoidosis of Costa is a rare papular palmoplantar keratosis characterized by small round-oval to rhomboid-shaped, yellowish papules most commonly localized to the palmar surface of the hands and sometimes also found on plantar surfaces of the feet. Both autosomal dominant and sporadic forms of the disease have been reported. Histologically acrokeratoelastoidosis is marked by hyperkeratosis and epidermal hypertrophy. Read More
J Am Acad Dermatol 2002 Sep;47(3):448-51
St. Joseph Hospital, and the Department of Dermatology, Baylor College of Medicine, Houston, Texas, USA.
Acrokeratoelastoidosis is a genodermatosis characterized by firm papules or plaques on the sides of the hands and feet. Although poorly understood, the lesions may result from an abnormality in the secretion or excretion of elastic material by fibroblasts in the dermis. In this report, we will present a patient with this rare condition and review the clinical and histopathologic features, cause, and differential diagnosis. Read More
Int J Dermatol 2002 May;41(5):291-3
Department of Dermatology, College of Medicine, University of Cincinnati, Ohio 45267-0592, USA.
Knuckle pads, first described by Garrod in 1893, 1 are benign, asymptomatic, well- circumscribed, smooth, firm, skin colored papules, nodules, or plaques. They most commonly occur on the dorsal aspect of the proximal interphalangeal joint of the finger, 2 but also may occur on the dorsal aspects of the foot over joints. 3-5 Knuckle pads may be inherited or acquired. Read More
J Am Acad Dermatol 2002 May;46(5):767-70
Department of Dermatology, National Defense Medical College, Tokorozawa, Saitama, Japan.
We describe acrokeratoelastoidosis-like lesions on the palms of the patients with systemic scleroderma. Histology showed a focal hyperkeratosis with or without epidermal concavity, regular acanthosis, and hyalinization of collagen fibers and, in some cases, fragmentation and diminution of elastic fibers in the deep dermis. A slight degree of fibrotic change of collagen in the uninvolved neighboring skin was found in one case. Read More
J Cutan Med Surg 2002 Jan-Feb;6(1):23-5. Epub 2002 Jan 9.
Department of Dermatology, Wake Forest University, Winston-Salem, North Carolina, USA.
Background: Keratoelastoidosis marginalis is a rare disease that is a variant of solar elastosis. Long-term ultraviolet radiation exposure and chronic trauma secondary to manual labor are considered to be inciting factors.
Objective: To outline the clinical and histological features of this disorder. Read More
Clin Exp Dermatol 2001 May;26(3):263-5
Section of Dermatology, University of Manchester, Hope Hospital, Salford, UK.
We report a man with a 3-year-history of a striking eruption of small, 2-3 mm diameter keratotic, crateriform papules distributed symmetrically over the lower limbs. Morphologically the individual papules closely resembled those described in acrokeratoelastoidosis (AK) of Costa and in focal acral hyperkeratosis of Dowd (FAH). The case is unusual, however, in that there was dramatic involvement of the legs but the hands and feet were largely spared. Read More
Int J Dermatol 2000 Jun;39(6):424-32
Department of Dermatology, University of Buenos Aires School of Medicine, Argentina.
Hautarzt 1999 Aug;50(8):586-9
Hautklinik des Städtischen Krankenhauses Hildesheim, D-32756 Detmold, Germany.
Focal acral hyperkeratosis is a disorder characterized by hyperkeratotic papules along the border of the hands and feet. Focal acral hyperkeratosis and several marginal punctate keratodermas closely resemble acrokeratoelastoidosis of Costa. The question if there is a difference between acrokeratoelastoidosis of Costa and focal acral hyperkeratosis or if they are variants of the same entity are discussed. Read More
J Cutan Pathol 1998 Nov;25(10):580-2
Servizio di Immunopatologia Cutanea, Università di Genova, Italy.
A 24-year-old black woman from Uganda was seen for treatment of multiple papules on her hands and feet. The lesions corresponded microscopically to foci of hyperkeratosis and acanthosis. Acid orcein stain revealed marked elastic fiber fragmentation. Read More
Int J Dermatol 1998 Jul;37(7):532-7
Department of Dermatology, Gea González Hospital, National Institute of Neurology, Mexico City, Mexico.
Background: In 1952, a Brazilian dermatologist, Oswaldo Costa, described a dermatosis characterized by accentuation of the cutaneous folds on the knuckles of both hands and small horny papules on the thenar eminences, posterior surface of the wrists, and the interdigital space between thumb and index finger; he called this entity acrokeratoelastoidosis. Other similar entities, such as focal acral hyperkeratosis and marginal keratoelastoidosis, have been described. The features of the different types of lenticular acral keratosis are discussed. Read More
Indian J Dermatol Venereol Leprol 1997 Sep-Oct;63(5):312-3
Department of Skin, STD and Leprosy, Dr. S.N. Medical College, Jodhpur, India.
Three cases of acrokeratoelastoidosis of Costa are reported. All the patients were females with marginal keratodermas composed of cornified papules, some of which were umbilicated, distributed along the borders of the hands and feet. A positive family history was present in all the cases. Read More
Clin Exp Dermatol 1997 Jan;22(1):62-4
Australas J Dermatol 1996 Nov;37(4):213-4
Monash Medical Centre, Clayton, Victoria, Australia.
An indian woman presented with crateriform and pearly papules along the lines of transgredience of the hands and feet. Her father and an older sister are similarly affected. Histology showed hyperkeratosis and elastorrhexis. Read More