Search our Database of Scientific Publications and Authors

I’m looking for a

    452 results match your criteria Acrodynia

    1 OF 10

    A Mercury Toxicity Case Complicated by Hyponatremia and Abnormal Endocrinological Test Results.
    Pediatrics 2017 Aug 13;140(2). Epub 2017 Jul 13.
    Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan
    Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. Read More

    Mercury Poisoning at a Home Day Care Center - Hillsborough County, Florida, 2015.
    MMWR Morb Mortal Wkly Rep 2017 May 5;66(17):433-435. Epub 2017 May 5.
    On November 12, 2015, the Florida Poison Information Center Tampa notified the Florida Department of Health in Hillsborough County of a boy aged 3 years with a urine mercury level of 79 μg/L (normal <10 μg/L). The patient had been admitted to the hospital on October 9, 2015 after a 3-4 week history of anorexia, weight loss, and lethargy. In the hospital, he developed a maculopapular rash, acrodynia (painful, pink discoloration of the hands and feet), tachycardia, hypertension, weakness, sweating, excessive salivation, and altered mental status. Read More

    Mercury toxicity presenting as acrodynia and a papulovesicular eruption in a 5-year-old girl.
    Dermatol Online J 2016 Mar 16;22(3). Epub 2016 Mar 16.
    University of California, Davis.
    Acrodynia is a reaction that occurs in children who have been exposed to mercury. Mercury toxicity has systemic manifestations as well as cutaneous manifestations, which can appear similar to those found in a number of other diseases. We present a case of acrodynia caused by mercury exposure in a previously healthy 5-year-old girl who developed hypertension, palmoplantar pruritus, and a papulovesicular eruption. Read More

    Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children.
    Int J Environ Res Public Health 2016 Jan 5;13(1). Epub 2016 Jan 5.
    Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Niaosong, Kaohsiung 83301, Taiwan.
    Kawasaki disease (KD) primarily affects children <5 years of age (75%-80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Read More

    Mercury poisoning in two 13-year-old twin sisters.
    J Res Med Sci 2015 Mar;20(3):308-11
    Department of Pediatrics, Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. Read More

    Genetic variation associated with hypersensitivity to mercury.
    Toxicol Int 2014 Sep-Dec;21(3):236-41
    Metabolic Research Unit, School of Medicine, Deakin University, Victoria.
    Objectives: Very little is known about mechanisms of idiosyncratic sensitivity to the damaging effects of mercury (Hg); however, there is likely a genetic component. The aim of the present study was to search for genetic variation in genes thought to be involved in Hg metabolism and transport in a group of individuals identified as having elevated Hg sensitivity compared to a normal control group.

    Materials And Methods: Survivors of pink disease (PD; infantile acrodynia) are a population of clinically identifiable individuals who are Hg sensitive. Read More

    Methodological issues and evidence of malfeasance in research purporting to show thimerosal in vaccines is safe.
    Biomed Res Int 2014 4;2014:247218. Epub 2014 Jun 4.
    Institute of Chronic Illness, Inc., 14 Redgate Court, Silver Spring, MD 20905, USA.
    There are over 165 studies that have focused on Thimerosal, an organic-mercury (Hg) based compound, used as a preservative in many childhood vaccines, and found it to be harmful. Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. In contrast, the United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is "no relationship between [T]himerosal[-]containing vaccines and autism rates in children. Read More

    Mercury promotes catecholamines which potentiate mercurial autoimmunity and vasodilation: implications for inositol 1,4,5-triphosphate 3-kinase C susceptibility in kawasaki syndrome.
    Korean Circ J 2013 Sep;43(9):581-91
    Shawnee, KS, USA.
    Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol 1,4,5-triphosphate 3-kinase C (ITPKC) susceptibility in KS would predispose patients to mercury by increasing Ca(2+) release. Hg(2+) sensitizes inositol 1,4,5-triphosphate (IP3) receptors at low doses, which release Ca(2+) from intracellular stores in the sarcoplasmic reticulum, resulting in delayed, repetitive calcium influx. ITPKC prevents IP3 from triggering IP3 receptors to release calcium by converting IP3 to inositol 1,3,4,5-tetrakisphosphate. Read More

    A history of the isolation and identification of vitamin B(6).
    Ann Nutr Metab 2012 26;61(3):236-8. Epub 2012 Nov 26.
    Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA. irwin.rosenberg @ tufts.edu
    In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed 'rat acrodynia', a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured 'rat acrodynia' was vitamin B(6). Other studies soon showed that vitamin B(6) deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Read More

    Elemental mercury poisoning presenting as hypertension in a young child.
    Pediatr Emerg Care 2012 Aug;28(8):812-4
    Department of Pediatrics, Rhode Island Hospital, Providence, RI 02903, USA.
    Mercury intoxication is an uncommon cause of hypertension in children and can mimic several other diseases, such as pheochromocytoma and vasculitis. Mercury intoxication can present as a diagnostic challenge because levels of catecholamines may be elevated, suggesting that the etiology is a catecholamine-secreting tumor. Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis. Read More

    ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.
    Autoimmun Rev 2012 Oct 1;11(12):903-8. Epub 2012 Apr 1.
    Shawnee, Kansas, USA.
    Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation of inositol 1,4,5-triphosphate (IP3), which releases calcium from intracellular stores, resulting from reduced genetic expression of ITPKC in carriers of the SNP. Reduced ITPKC activity would increase IP3 levels, and thus, increase calcium release. Read More

    Acrodynia and hypertension in a young girl secondary to elemental mercury toxicity acquired in the home.
    Pediatr Dermatol 2012 Mar-Apr;29(2):199-201
    Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903, USA.
    Acrodynia, also known as pink disease, erythredema polyneuropathy, Feer syndrome, and raw-beef hands and feet, is thought to be a toxic reaction to elemental mercury and less commonly to organic and inorganic forms. Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the modern world because of regulations to eliminate mercury from personal care products, household items, medications, and vaccinations. We present a case of a 3-year-old girl with acrodynia secondary to toxic exposure to elemental mercury in the home environment. Read More

    Metallic mercury vapour poisoning revisited.
    Australas J Dermatol 2011 Nov 16;52(4):e5-7. Epub 2010 Aug 16.
    Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
    Mercury poisoning was once common in the 19th century. With its declining use, now clinicians and the public in general are often unaware and unsuspecting of mercury toxicity. A 40-year-old woman and her two children were hospitalized with a 1-week history of a generalized lichenoid eruption. Read More

    Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran.
    Hum Exp Toxicol 2012 Feb 29;31(2):193-6. Epub 2011 Jul 29.
    Department of Pediatrics, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
    Elemental mercury (Hg) is the only metal which evaporates in room temperature and its inhalation may cause toxicity. Hg poisoning may occur by mishandling the metal, particularly in children who play with it. Wide-spectrum of the clinical presentations of chronic Hg poisoning may cause misdiagnosis, particularly when history of exposure is unknown. Read More

    Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism spectrum disorders.
    J Toxicol Environ Health A 2011 ;74(18):1185-94
    Swinburne Autism Bio-Research Initiative (SABRI), Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, Victoria, Australia.
    Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Read More

    Localized aquadynia responsive to clonidine in a 13-year-old girl.
    Pediatr Dermatol 2010 Nov-Dec;27(6):646-9. Epub 2010 Nov 16.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
    A 13-year-old girl sought medical care for pain in both palms that consistently occurred after brief exposure to water and resolved spontaneously 20 to 30 minutes after immersion. The pain was not associated with wrinkling of the palms. After excluding other causes of acrodynia and water-induced discomfort, we diagnosed the patient as having idiopathic localized aquadynia. Read More

    Mercury poisoning: a rare but treatable cause of failure to thrive and developmental regression in an infant.
    Hong Kong Med J 2009 Feb;15(1):61-4
    Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Laichikok, Hong Kong.
    An infant presented with failure to thrive and developmental regression. Physical examination revealed an irritable child with swollen, erythematous extremities, and elevated blood pressure. Extensive investigations, including a metabolic work-up and neuroimaging, were unrevealing. Read More

    Kawasaki's disease, acrodynia, and mercury.
    Curr Med Chem 2008 ;15(28):3000-10
    Department of Environmental and Complementary Medicine, Salusmed Medical Center, Wieslistrasse 34, CH - 8267 Berlingen, Switzerland.
    A superantigen or autoimmunity has been hypothesized to be the main cause of the Kawasaki's Disease but the etiology is unknown. Medical literature, epidemiological findings, and some case reports have suggested that mercury may play a pathogenic role. Several patients with Kawasaki's Disease have presented with elevated urine mercury levels compared to matched controls. Read More

    A previously healthy 11-year-old girl with behavioural disturbances, desquamation of the skin and loss of teeth.
    Eur J Pediatr 2009 Apr 29;168(4):509-11. Epub 2008 Nov 29.
    Department of Paediatrics, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands.
    An 11-year-old girl was admitted with backpain, weight loss, fatigue and behavioural disturbances, starting seven weeks before admission. Physical examination showed acrodynia, tremor, cachexia, hypertension and extensive gingival ulceration. Routine laboratory tests were normal, except for a CRP of 98 mg/l. Read More

    Mercury (Hg) and lead (Pb) in interior and exterior New Orleans house paint films.
    Chemosphere 2008 Jun 15;72(6):882-5. Epub 2008 May 15.
    Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
    Pre-1992, latex paint was formulated with mercury (Hg) as phenylmercuric acetate (PMA). Hg vaporizes reducing its content, and lead (Pb) is stable and remains unchanged. The objective of this study is to describe the content of Hg and Pb in existing paint coatings. Read More

    Mercury intoxication: lack of correlation between symptoms and levels.
    Clin Pediatr (Phila) 2007 Nov 19;46(9):844-6. Epub 2007 Jul 19.
    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9063, USA.
    The incidence of mercury intoxication has decreased considerably because of stricter public health regulations. However, it has not been completely eliminated and should be considered in a child with unexplained tachycardia, hypertension, mood changes, weight loss, and acrodynia. Mercury intoxication can be difficult to differentiate from pheochromocytoma and Kawasaki's disease. Read More

    Mercury intoxication in a 2-year-old girl: a diagnostic challenge for the physician.
    Pediatr Nephrol 2007 Jun 20;22(6):903-6. Epub 2007 Feb 20.
    Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.
    A 2-year-old girl presented with hypertension, anorexia and vomiting, restlessness, insomnia and acrodynia. Her blood pressure upon arrival was 145/98 mmHg. Ultrasound of the abdomen, CT scan of chest, abdomen and pelvis, and echocardiogram, were normal. Read More

    A Child with elemental mercury poisoning and unusual brain MRI findings.
    Clin Toxicol (Phila) 2006 ;44(1):85-8
    Pediatrics Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
    Mercury vapor poisoning is a serious and potentially fatal problem. Neurological manifestations involving the central nervous system are seen with chronic mercury intoxication. We present the case of a 10-year-old child who demonstrated acrodynia, seizures, and visual impairment following 20 days of exposure to elemental mercury at home. Read More

    Mercury intoxication: it still exists.
    Pediatr Dermatol 2004 May-Jun;21(3):254-9
    Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
    A3-year-old boy presented to the Hospital for Sick Children with systemic symptoms and oropharyngeal and peripheral extremity changes suggestive of Kawasaki disease. He was found to have severe hypertension. Investigation for a catecholamine-secreting tumor was negative. Read More

    Dose-response study of thimerosal-induced murine systemic autoimmunity.
    Toxicol Appl Pharmacol 2004 Jan;194(2):169-79
    Molecular and Immunological Pathology (AIR), Department of Molecular and Clinical Medicine, Linköping University, SE-581 85 Linköping, Sweden.
    The organic compound ethylmercurithiosalicylate (thimerosal), which is primarily present in the tissues as ethylmercury, has caused illness and several deaths due to erroneous handling when used as a disinfectant or as a preservative in medical preparations. Lately, possible health effects of thimerosal in childhood vaccines have been much discussed. Thimerosal is a well-known sensitizing agent, although usually of no clinical relevance. Read More

    Mercury exposure and early effects: an overview.
    Med Lav 2002 May-Jun;93(3):139-47
    Environmental Geochemistry Research Group, Department of Environmental Science and Technology, Imperial College of Science, Technology & Medicine, Prince Consort Road, London SW7 2BP, UK.
    Objectives: This paper was given as a keynote address at the conference on The Assessment of the Effects Due to Low Doses of Inorganic Mercury following Environmental and Occupational Exposures: Human and in vitro Studies on the Specific Mechanisms of Toxicity in Gargnano, Italy, in September 2001.

    Methods: The most relevant literature over the past 40 years has been reviewed, and in particular, the proceedings of the World Health Organisation conferences on the health effects of inorganic and organic mercury exposure have been considered.

    Results: In an uncontaminated environment the general population is exposed to mercury vapour from the atmosphere and from dental amalgam, while the diet, mainly from fish, is the principal source for methyl mercury absorption. Read More

    Mercury exposure and cutaneous disease.
    J Am Acad Dermatol 2000 Jul;43(1 Pt 1):81-90
    Department of Medicine (Dermatology), Vanderbilt University, Nashville, TN, USA.
    Human contact with mercury has been ongoing for centuries and was previously considered a legitimate means of treating different cutaneous and systemic conditions. Toxicity from this heavy metal may occur from exposure to elemental, inorganic, and organic forms of mercury. This article outlines the signs and symptoms of mercury poisoning and the different clinical conditions with assorted cutaneous findings. Read More

    Mercury intoxication and arterial hypertension: report of two patients and review of the literature.
    Pediatrics 2000 Mar;105(3):E34
    Department of Pediatric Nephrology, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA.
    Two children in the same household with symptomatic arterial hypertension simulating pheochromocytoma were found to be intoxicated with elemental mercury. The first child was a 4-year-old boy who presented with new-onset seizures, rash, and painful extremities, who was found to have a blood pressure of 171/123 mm Hg. An extensive investigation ensued. Read More

    The rise and fall of pink disease.
    Soc Hist Med 1997 Aug;10(2):291-304
    Wellcome Institute for the History of Medicine, London.
    This paper explores the social and medical history and context of pink disease (acrodynia), a serious disease of infants and young children that baffled the medical world during the first half of the twentieth century until it was shown to be caused by mercury poisoning. In the English-speaking world the commonest source of the mercury was teething powders, which were widely available and advertised with increasing sophistication. Efforts to control them (such as the BMJ's campaign against 'Secret Remedies') were as yet unsuccessful. Read More

    A study of autoantibodies and circulating immune complexes in mercury-exposed chloralkali workers.
    Int Arch Occup Environ Health 1997 ;70(2):101-6
    Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
    Unlabelled: Inorganic mercury may cause immunologically mediated disease: e.g., glomerulonephritis, acrodynia, and contact allergy. Read More

    From Morvan's fibrillary chorea to the "mal des ardents".
    J Hist Neurosci 1996 Dec;5(3):265-73
    The authors present a case of Morvan's fibrillary chorea. We compare this observation with cases in the past such as the "mal des ardents", the plague of Athens, acrodynia and the epidemic of Pont St Esprit which were all characterized clinically by pain, burning sensations, hallucinations and insomnia. Since aetiological aspects remain uncertain, the similarity in clinical observations establishes a close relationship between the "mal des ardents" and the clinical features of our patient. Read More

    [False erythermalgia].
    J Mal Vasc 1996 ;21(2):84-7
    Service de Médecine vasculaire et d'Hypertension artérielle, Hôpital Saint-Joseph, Paris.
    The differential diagnosis of erythermalgia is sometimes complicated by the absence of consensus on proposed diagnostic criteria. Unwarranted diagnosis can result from any clinical situation leading to burning sensations in the limbs. This can occurs in patients with peripheral neuropathies who often experience dysesthesia when going to bed when the legs are under the covers; in such cases, redness and local warmth are missing. Read More

    Painful fingers, heat intolerance, and telangiectases of the ear: easily ignored childhood signs of Fabry disease.
    Pediatr Dermatol 1995 Sep;12(3):215-9
    Department of Medicine, Medical College of Ohio, Toledo 43699, USA.
    Generalized anhidrosis with heat collapse, painful fingers, and angiokeratomas were the presenting signs in a 23-year-old man who was shown by enzyme studies and electron microscopy to have Fabry disease. His 6-year-old brother had the early diagnostic findings of episodic painful fingers, heat intolerance, and retroauricular telangiectasia. Both had an absence of alpha-galactosidase. Read More

    [Arterial hypertension due to mercury poisoning: diagnostic value of captopril].
    Arch Pediatr 1995 Jan;2(1):43-6
    Service de pédiatrie R, hôpital Gatien-de-Clocheville, Tours, France.
    Background: Mercury poisoning is a rare cause of hypertension in children. Urinary excretion sometimes remains low despite severe clinical intoxication.

    Case Report: A 32 month-old girl was admitted with hypertension, tachycardia, apathy, irritability and excessive sweating. Read More

    Immune thrombocytopenia and elemental mercury poisoning.
    J Toxicol Clin Toxicol 1995 ;33(5):449-55
    Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City 52242-1100, USA.
    Three cases of severe mercury toxicity occurring within a family are reported. Two cases of thrombocytopenia occurred in this family and represent the second such report in the literature of an association between elemental mercury toxicity and thrombocytopenia. Three of the children presented with a combination of dermatologic and neurologic manifestations reminiscent of acrodynia or pink disease. Read More

    Premature exfoliation of teeth in childhood and adolescence.
    Adv Pediatr 1994 ;41:453-70
    Department of Oral-Facial Development, Indiana University School of Dentistry, Indianapolis.
    Although the premature loss of primary teeth in conjunction with early eruption may be of no clinical significance, the loss of primary or permanent teeth in the absence of trauma should not be overlooked by the clinician. Premature loss of teeth associated with systemic disease usually results from some change in the immune system or connective tissue. This chapter presented some conditions associated with loosening and/or premature loss of teeth that may be encountered in children and adolescents. Read More

    1 OF 10