461 results match your criteria Acrodynia


Palmoplantar eruption in a patient with mercury poisoning.

Cutis 2020 Nov;106(5):265-267

Department of Dermatology, John P. and Kathrine G. McGovern Medical School at the University of Texas Health Science Center at Houston, USA.

Mercury poisoning is a rare event that can present with a variety of nonspecific systemic symptoms, making it difficult to diagnose. Dermatologic manifestations of mercury exposure may be variable and include pink disease (acrodynia), mercury exanthem, contact dermatitis, and cutaneous granulomas. We present the case of an 18-year-old woman with a palmoplantar eruption associated with tachycardia, hyperhidrosis, myalgia, paresthesia, and muscle fasciculations. Read More

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November 2020

Mercury intoxication resembling pediatric rheumatic diseases: case series and literature review.

Rheumatol Int 2020 Aug 27;40(8):1333-1342. Epub 2020 Apr 27.

Cerrahpasa Medical School, Department of Pediatric Rheumatology, Istanbul University-Cerrahpasa, Istanbul, Turkey.

Mercury is the only metal that remains in liquid form at the room temperature. It is a very toxic metal and even short-term exposure can lead to poisoning. Mercury intoxication can affect many systems such as skin, cardiovascular, genitourinary, central and peripheral nervous, respiratory, and musculoskeletal system. Read More

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Elemental mercury intoxication in 7 patients admitted to a pediatric rheumatology clinic.

Turk J Pediatr 2019 ;61(5):786-790

Departments of Pediatric Rheumatology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Paç Kısaarslan A, Sözeri B, Baştuğ F, Gündüz Z, Yel S, Nalçacıoğlu H, Şahin N, Özdemir Çiçek S, Poyrazoğlu H, Düşünsel R. Elemental mercury intoxication in 7 patients admitted to a pediatric rheumatology clinic. Turk J Pediatr 2019; 61: 786-790. Read More

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Mercury-induced autoimmunity: Drifting from micro to macro concerns on autoimmune disorders.

Clin Immunol 2020 04 4;213:108352. Epub 2020 Feb 4.

Faculty of Medicine, University of Porto, Porto, Portugal; Institute for Research and Innovation in Health (I3S), University of Porto, Porto, Portugal.

Mercury (Hg) is widely recognized as a neurotoxic metal, besides it can also act as a proinflammatory agent and immunostimulant, depending on individual exposure and susceptibility. Mercury exposure may arise from internal body pathways, such as via dental amalgams, preservatives in drugs and vaccines, and seafood consumption, or even from external pathways, i.e. Read More

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Microbial Protein Produced from Brown Seaweed and Spruce Wood as a Feed Ingredient.

J Agric Food Chem 2018 Aug 25;66(31):8328-8335. Epub 2018 Jul 25.

The conversion of nonedible biomass to protein for use in feed is an attractive strategy toward improved sustainability in aquaculture. We have studied the possibility to produce protein-rich yeast Candida utilis on a medium consisting of enzymatically hydrolyzed sulphite-pulped spruce wood, mainly providing glucose, and enzymatically hydrolyzed brown seaweed, supplemented with ammonium sulfate. The results show that this blend constitutes a complete fermentation medium that enables good growth rates and cell yields. Read More

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A Mercury Toxicity Case Complicated by Hyponatremia and Abnormal Endocrinological Test Results.

Pediatrics 2017 Aug 13;140(2). Epub 2017 Jul 13.

Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan

Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. Read More

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Mercury Poisoning at a Home Day Care Center - Hillsborough County, Florida, 2015.

MMWR Morb Mortal Wkly Rep 2017 May 5;66(17):433-435. Epub 2017 May 5.

On November 12, 2015, the Florida Poison Information Center Tampa notified the Florida Department of Health in Hillsborough County of a boy aged 3 years with a urine mercury level of 79 μg/L (normal <10 μg/L). The patient had been admitted to the hospital on October 9, 2015 after a 3-4 week history of anorexia, weight loss, and lethargy. In the hospital, he developed a maculopapular rash, acrodynia (painful, pink discoloration of the hands and feet), tachycardia, hypertension, weakness, sweating, excessive salivation, and altered mental status. Read More

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Mercury toxicity presenting as acrodynia and a papulovesicular eruption in a 5-year-old girl.

Dermatol Online J 2016 Mar 16;22(3). Epub 2016 Mar 16.

University of California, Davis.

Acrodynia is a reaction that occurs in children who have been exposed to mercury. Mercury toxicity has systemic manifestations as well as cutaneous manifestations, which can appear similar to those found in a number of other diseases. We present a case of acrodynia caused by mercury exposure in a previously healthy 5-year-old girl who developed hypertension, palmoplantar pruritus, and a papulovesicular eruption. Read More

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Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children.

Int J Environ Res Public Health 2016 Jan 5;13(1). Epub 2016 Jan 5.

Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Niaosong, Kaohsiung 83301, Taiwan.

Kawasaki disease (KD) primarily affects children <5 years of age (75%-80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Read More

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January 2016

Mercury poisoning in two 13-year-old twin sisters.

J Res Med Sci 2015 Mar;20(3):308-11

Department of Pediatrics, Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. Read More

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Genetic variation associated with hypersensitivity to mercury.

Toxicol Int 2014 Sep-Dec;21(3):236-41

Metabolic Research Unit, School of Medicine, Deakin University, Victoria.

Objectives: Very little is known about mechanisms of idiosyncratic sensitivity to the damaging effects of mercury (Hg); however, there is likely a genetic component. The aim of the present study was to search for genetic variation in genes thought to be involved in Hg metabolism and transport in a group of individuals identified as having elevated Hg sensitivity compared to a normal control group.

Materials And Methods: Survivors of pink disease (PD; infantile acrodynia) are a population of clinically identifiable individuals who are Hg sensitive. Read More

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Methodological issues and evidence of malfeasance in research purporting to show thimerosal in vaccines is safe.

Biomed Res Int 2014 4;2014:247218. Epub 2014 Jun 4.

Institute of Chronic Illness, Inc., 14 Redgate Court, Silver Spring, MD 20905, USA.

There are over 165 studies that have focused on Thimerosal, an organic-mercury (Hg) based compound, used as a preservative in many childhood vaccines, and found it to be harmful. Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. In contrast, the United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is "no relationship between [T]himerosal[-]containing vaccines and autism rates in children. Read More

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February 2015

Mercury promotes catecholamines which potentiate mercurial autoimmunity and vasodilation: implications for inositol 1,4,5-triphosphate 3-kinase C susceptibility in kawasaki syndrome.

Korean Circ J 2013 Sep;43(9):581-91

Shawnee, KS, USA.

Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol 1,4,5-triphosphate 3-kinase C (ITPKC) susceptibility in KS would predispose patients to mercury by increasing Ca(2+) release. Hg(2+) sensitizes inositol 1,4,5-triphosphate (IP3) receptors at low doses, which release Ca(2+) from intracellular stores in the sarcoplasmic reticulum, resulting in delayed, repetitive calcium influx. ITPKC prevents IP3 from triggering IP3 receptors to release calcium by converting IP3 to inositol 1,3,4,5-tetrakisphosphate. Read More

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September 2013

A history of the isolation and identification of vitamin B(6).

Ann Nutr Metab 2012 26;61(3):236-8. Epub 2012 Nov 26.

Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA. irwin.rosenberg @ tufts.edu

In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed 'rat acrodynia', a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured 'rat acrodynia' was vitamin B(6). Other studies soon showed that vitamin B(6) deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Read More

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Elemental mercury poisoning presenting as hypertension in a young child.

Pediatr Emerg Care 2012 Aug;28(8):812-4

Department of Pediatrics, Rhode Island Hospital, Providence, RI 02903, USA.

Mercury intoxication is an uncommon cause of hypertension in children and can mimic several other diseases, such as pheochromocytoma and vasculitis. Mercury intoxication can present as a diagnostic challenge because levels of catecholamines may be elevated, suggesting that the etiology is a catecholamine-secreting tumor. Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis. Read More

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A hypertensive child with irritability and a rash.

Pediatr Emerg Care 2012 Jun;28(6):581-3

Oregon Health & Sciences University Portland, OR, USA.

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ITPKC susceptibility in Kawasaki syndrome as a sensitizing factor for autoimmunity and coronary arterial wall relaxation induced by thimerosal's effects on calcium signaling via IP3.

Autoimmun Rev 2012 Oct 1;11(12):903-8. Epub 2012 Apr 1.

Shawnee, Kansas, USA.

Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation of inositol 1,4,5-triphosphate (IP3), which releases calcium from intracellular stores, resulting from reduced genetic expression of ITPKC in carriers of the SNP. Reduced ITPKC activity would increase IP3 levels, and thus, increase calcium release. Read More

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October 2012

Acrodynia and hypertension in a young girl secondary to elemental mercury toxicity acquired in the home.

Pediatr Dermatol 2012 Mar-Apr;29(2):199-201

Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903, USA.

Acrodynia, also known as pink disease, erythredema polyneuropathy, Feer syndrome, and raw-beef hands and feet, is thought to be a toxic reaction to elemental mercury and less commonly to organic and inorganic forms. Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the modern world because of regulations to eliminate mercury from personal care products, household items, medications, and vaccinations. We present a case of a 3-year-old girl with acrodynia secondary to toxic exposure to elemental mercury in the home environment. Read More

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Metallic mercury vapour poisoning revisited.

Australas J Dermatol 2011 Nov 16;52(4):e5-7. Epub 2010 Aug 16.

Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

Mercury poisoning was once common in the 19th century. With its declining use, now clinicians and the public in general are often unaware and unsuspecting of mercury toxicity. A 40-year-old woman and her two children were hospitalized with a 1-week history of a generalized lichenoid eruption. Read More

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November 2011

Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran.

Hum Exp Toxicol 2012 Feb 29;31(2):193-6. Epub 2011 Jul 29.

Department of Pediatrics, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Elemental mercury (Hg) is the only metal which evaporates in room temperature and its inhalation may cause toxicity. Hg poisoning may occur by mishandling the metal, particularly in children who play with it. Wide-spectrum of the clinical presentations of chronic Hg poisoning may cause misdiagnosis, particularly when history of exposure is unknown. Read More

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February 2012

Ancestry of pink disease (infantile acrodynia) identified as a risk factor for autism spectrum disorders.

J Toxicol Environ Health A 2011 ;74(18):1185-94

Swinburne Autism Bio-Research Initiative (SABRI), Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, Victoria, Australia.

Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Read More

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September 2011

Localized aquadynia responsive to clonidine in a 13-year-old girl.

Pediatr Dermatol 2010 Nov-Dec;27(6):646-9. Epub 2010 Nov 16.

Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.

A 13-year-old girl sought medical care for pain in both palms that consistently occurred after brief exposure to water and resolved spontaneously 20 to 30 minutes after immersion. The pain was not associated with wrinkling of the palms. After excluding other causes of acrodynia and water-induced discomfort, we diagnosed the patient as having idiopathic localized aquadynia. Read More

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Mercury exposure and children's health. Foreword.

Authors:
Ruth A Etzel

Curr Probl Pediatr Adolesc Health Care 2010 Sep;40(8):185

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September 2010

Mercury poisoning: a rare but treatable cause of failure to thrive and developmental regression in an infant.

Hong Kong Med J 2009 Feb;15(1):61-4

Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Laichikok, Hong Kong.

An infant presented with failure to thrive and developmental regression. Physical examination revealed an irritable child with swollen, erythematous extremities, and elevated blood pressure. Extensive investigations, including a metabolic work-up and neuroimaging, were unrevealing. Read More

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February 2009

Kawasaki's disease, acrodynia, and mercury.

Authors:
J Mutter D Yeter

Curr Med Chem 2008 ;15(28):3000-10

Department of Environmental and Complementary Medicine, Salusmed Medical Center, Wieslistrasse 34, CH - 8267 Berlingen, Switzerland.

A superantigen or autoimmunity has been hypothesized to be the main cause of the Kawasaki's Disease but the etiology is unknown. Medical literature, epidemiological findings, and some case reports have suggested that mercury may play a pathogenic role. Several patients with Kawasaki's Disease have presented with elevated urine mercury levels compared to matched controls. Read More

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January 2009

A previously healthy 11-year-old girl with behavioural disturbances, desquamation of the skin and loss of teeth.

Eur J Pediatr 2009 Apr 29;168(4):509-11. Epub 2008 Nov 29.

Department of Paediatrics, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands.

An 11-year-old girl was admitted with backpain, weight loss, fatigue and behavioural disturbances, starting seven weeks before admission. Physical examination showed acrodynia, tremor, cachexia, hypertension and extensive gingival ulceration. Routine laboratory tests were normal, except for a CRP of 98 mg/l. Read More

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Mercury (Hg) and lead (Pb) in interior and exterior New Orleans house paint films.

Chemosphere 2008 Jun 15;72(6):882-5. Epub 2008 May 15.

Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.

Pre-1992, latex paint was formulated with mercury (Hg) as phenylmercuric acetate (PMA). Hg vaporizes reducing its content, and lead (Pb) is stable and remains unchanged. The objective of this study is to describe the content of Hg and Pb in existing paint coatings. Read More

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Mercury intoxication: lack of correlation between symptoms and levels.

Clin Pediatr (Phila) 2007 Nov 19;46(9):844-6. Epub 2007 Jul 19.

Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9063, USA.

The incidence of mercury intoxication has decreased considerably because of stricter public health regulations. However, it has not been completely eliminated and should be considered in a child with unexplained tachycardia, hypertension, mood changes, weight loss, and acrodynia. Mercury intoxication can be difficult to differentiate from pheochromocytoma and Kawasaki's disease. Read More

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November 2007

Mercury intoxication in a 2-year-old girl: a diagnostic challenge for the physician.

Pediatr Nephrol 2007 Jun 20;22(6):903-6. Epub 2007 Feb 20.

Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.

A 2-year-old girl presented with hypertension, anorexia and vomiting, restlessness, insomnia and acrodynia. Her blood pressure upon arrival was 145/98 mmHg. Ultrasound of the abdomen, CT scan of chest, abdomen and pelvis, and echocardiogram, were normal. Read More

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