454 results match your criteria Acrodynia
J Agric Food Chem 2018 Aug 25;66(31):8328-8335. Epub 2018 Jul 25.
The conversion of nonedible biomass to protein for use in feed is an attractive strategy toward improved sustainability in aquaculture. We have studied the possibility to produce protein-rich yeast Candida utilis on a medium consisting of enzymatically hydrolyzed sulphite-pulped spruce wood, mainly providing glucose, and enzymatically hydrolyzed brown seaweed, supplemented with ammonium sulfate. The results show that this blend constitutes a complete fermentation medium that enables good growth rates and cell yields. Read More
Pediatrics 2017 Aug 13;140(2). Epub 2017 Jul 13.
Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan
Mercury (Hg) poisoning is considered a rare disease by the National Institutes of Health and the diagnosis can present great challenges to clinicians. Children who are exposed to Hg can present with a wide variety of symptoms, including acrodynia, tremor, excessive salivation, and psychiatric symptoms, including insomnia. However, endocrinologic manifestations from Hg exposure are less well known. Read More
MMWR Morb Mortal Wkly Rep 2017 May 5;66(17):433-435. Epub 2017 May 5.
On November 12, 2015, the Florida Poison Information Center Tampa notified the Florida Department of Health in Hillsborough County of a boy aged 3 years with a urine mercury level of 79 μg/L (normal <10 μg/L). The patient had been admitted to the hospital on October 9, 2015 after a 3-4 week history of anorexia, weight loss, and lethargy. In the hospital, he developed a maculopapular rash, acrodynia (painful, pink discoloration of the hands and feet), tachycardia, hypertension, weakness, sweating, excessive salivation, and altered mental status. Read More
Dermatol Online J 2016 Mar 16;22(3). Epub 2016 Mar 16.
University of California, Davis.
Acrodynia is a reaction that occurs in children who have been exposed to mercury. Mercury toxicity has systemic manifestations as well as cutaneous manifestations, which can appear similar to those found in a number of other diseases. We present a case of acrodynia caused by mercury exposure in a previously healthy 5-year-old girl who developed hypertension, palmoplantar pruritus, and a papulovesicular eruption. Read More
Int J Environ Res Public Health 2016 Jan 5;13(1). Epub 2016 Jan 5.
Kawasaki Disease Center, Kaohsiung Chang Gung Memorial Hospital, Niaosong, Kaohsiung 83301, Taiwan.
Kawasaki disease (KD) primarily affects children <5 years of age (75%-80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Read More
J Res Med Sci 2015 Mar;20(3):308-11
Department of Pediatrics, Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. Read More
Toxicol Int 2014 Sep-Dec;21(3):236-41
Metabolic Research Unit, School of Medicine, Deakin University, Victoria.
Objectives: Very little is known about mechanisms of idiosyncratic sensitivity to the damaging effects of mercury (Hg); however, there is likely a genetic component. The aim of the present study was to search for genetic variation in genes thought to be involved in Hg metabolism and transport in a group of individuals identified as having elevated Hg sensitivity compared to a normal control group.
Materials And Methods: Survivors of pink disease (PD; infantile acrodynia) are a population of clinically identifiable individuals who are Hg sensitive. Read More
Biomed Res Int 2014 4;2014:247218. Epub 2014 Jun 4.
Institute of Chronic Illness, Inc., 14 Redgate Court, Silver Spring, MD 20905, USA.
There are over 165 studies that have focused on Thimerosal, an organic-mercury (Hg) based compound, used as a preservative in many childhood vaccines, and found it to be harmful. Of these, 16 were conducted to specifically examine the effects of Thimerosal on human infants or children with reported outcomes of death; acrodynia; poisoning; allergic reaction; malformations; auto-immune reaction; Well's syndrome; developmental delay; and neurodevelopmental disorders, including tics, speech delay, language delay, attention deficit disorder, and autism. In contrast, the United States Centers for Disease Control and Prevention states that Thimerosal is safe and there is "no relationship between [T]himerosal[-]containing vaccines and autism rates in children. Read More
Korean Circ J 2013 Sep;43(9):581-91
Shawnee, KS, USA.
Previously, we reviewed biological evidence that mercury could induce autoimmunity and coronary arterial wall relaxation as observed in Kawasaki syndrome (KS) through its effects on calcium signaling, and that inositol 1,4,5-triphosphate 3-kinase C (ITPKC) susceptibility in KS would predispose patients to mercury by increasing Ca(2+) release. Hg(2+) sensitizes inositol 1,4,5-triphosphate (IP3) receptors at low doses, which release Ca(2+) from intracellular stores in the sarcoplasmic reticulum, resulting in delayed, repetitive calcium influx. ITPKC prevents IP3 from triggering IP3 receptors to release calcium by converting IP3 to inositol 1,3,4,5-tetrakisphosphate. Read More
Ann Nutr Metab 2012 26;61(3):236-8. Epub 2012 Nov 26.
Jean Mayer USDA Human Nutrition Research Center on Aging and Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA. irwin.rosenberg @ tufts.edu
In the 1930s, Rudolf Peters showed that young rats kept on a semi-synthetic diet with added thiamin and riboflavin but no other supplement developed 'rat acrodynia', a condition characterized by severe cutaneous lesions. In 1934, Paul György showed that the factor which cured 'rat acrodynia' was vitamin B(6). Other studies soon showed that vitamin B(6) deficiency produced convulsions in rats, pigs, and dogs, and a microcytic anemia in certain animals. Read More
Pediatr Emerg Care 2012 Aug;28(8):812-4
Department of Pediatrics, Rhode Island Hospital, Providence, RI 02903, USA.
Mercury intoxication is an uncommon cause of hypertension in children and can mimic several other diseases, such as pheochromocytoma and vasculitis. Mercury intoxication can present as a diagnostic challenge because levels of catecholamines may be elevated, suggesting that the etiology is a catecholamine-secreting tumor. Once acrodynia is identified as a primary symptom, a 24-hour urine mercury level can confirm the diagnosis. Read More
Pediatr Emerg Care 2012 Jun;28(6):581-3
Oregon Health & Sciences University Portland, OR, USA.
Autoimmun Rev 2012 Oct 1;11(12):903-8. Epub 2012 Apr 1.
Shawnee, Kansas, USA.
Recently, a single nucleotide polymorphism (SNP) of the inositol 1,4,5-triphosphate kinase C (ITPKC), rs28493229, was found to passively confer susceptibility for Kawasaki syndrome (KS) and subsequent coronary arterial lesions. This association is believed to be the result of defective phosphorylation of inositol 1,4,5-triphosphate (IP3), which releases calcium from intracellular stores, resulting from reduced genetic expression of ITPKC in carriers of the SNP. Reduced ITPKC activity would increase IP3 levels, and thus, increase calcium release. Read More
Pediatr Dermatol 2012 Mar-Apr;29(2):199-201
Department of Dermatology, Warren Alpert Medical School, Brown University, Providence, Rhode Island 02903, USA.
Acrodynia, also known as pink disease, erythredema polyneuropathy, Feer syndrome, and raw-beef hands and feet, is thought to be a toxic reaction to elemental mercury and less commonly to organic and inorganic forms. Occurring commonly in the early 20th century, acrodynia is now a seemingly extinct disease in the modern world because of regulations to eliminate mercury from personal care products, household items, medications, and vaccinations. We present a case of a 3-year-old girl with acrodynia secondary to toxic exposure to elemental mercury in the home environment. Read More
Australas J Dermatol 2011 Nov 16;52(4):e5-7. Epub 2010 Aug 16.
Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.
Mercury poisoning was once common in the 19th century. With its declining use, now clinicians and the public in general are often unaware and unsuspecting of mercury toxicity. A 40-year-old woman and her two children were hospitalized with a 1-week history of a generalized lichenoid eruption. Read More
Hum Exp Toxicol 2012 Feb 29;31(2):193-6. Epub 2011 Jul 29.
Department of Pediatrics, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Elemental mercury (Hg) is the only metal which evaporates in room temperature and its inhalation may cause toxicity. Hg poisoning may occur by mishandling the metal, particularly in children who play with it. Wide-spectrum of the clinical presentations of chronic Hg poisoning may cause misdiagnosis, particularly when history of exposure is unknown. Read More
J Toxicol Environ Health A 2011 ;74(18):1185-94
Swinburne Autism Bio-Research Initiative (SABRI), Brain and Psychological Sciences Research Centre, Swinburne University of Technology, Hawthorn, Victoria, Australia.
Pink disease (infantile acrodynia) was especially prevalent in the first half of the 20th century. Primarily attributed to exposure to mercury (Hg) commonly found in teething powders, the condition was developed by approximately 1 in 500 exposed children. The differential risk factor was identified as an idiosyncratic sensitivity to Hg. Read More
Pediatr Dermatol 2010 Nov-Dec;27(6):646-9. Epub 2010 Nov 16.
Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905, USA.
A 13-year-old girl sought medical care for pain in both palms that consistently occurred after brief exposure to water and resolved spontaneously 20 to 30 minutes after immersion. The pain was not associated with wrinkling of the palms. After excluding other causes of acrodynia and water-induced discomfort, we diagnosed the patient as having idiopathic localized aquadynia. Read More
Curr Probl Pediatr Adolesc Health Care 2010 Sep;40(8):185
Hong Kong Med J 2009 Feb;15(1):61-4
Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Laichikok, Hong Kong.
An infant presented with failure to thrive and developmental regression. Physical examination revealed an irritable child with swollen, erythematous extremities, and elevated blood pressure. Extensive investigations, including a metabolic work-up and neuroimaging, were unrevealing. Read More
Curr Med Chem 2008 ;15(28):3000-10
Department of Environmental and Complementary Medicine, Salusmed Medical Center, Wieslistrasse 34, CH - 8267 Berlingen, Switzerland.
A superantigen or autoimmunity has been hypothesized to be the main cause of the Kawasaki's Disease but the etiology is unknown. Medical literature, epidemiological findings, and some case reports have suggested that mercury may play a pathogenic role. Several patients with Kawasaki's Disease have presented with elevated urine mercury levels compared to matched controls. Read More
Eur J Pediatr 2009 Apr 29;168(4):509-11. Epub 2008 Nov 29.
Department of Paediatrics, Canisius Wilhelmina Hospital, P.O. Box 9015, 6500 GS, Nijmegen, The Netherlands.
An 11-year-old girl was admitted with backpain, weight loss, fatigue and behavioural disturbances, starting seven weeks before admission. Physical examination showed acrodynia, tremor, cachexia, hypertension and extensive gingival ulceration. Routine laboratory tests were normal, except for a CRP of 98 mg/l. Read More
Chemosphere 2008 Jun 15;72(6):882-5. Epub 2008 May 15.
Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
Pre-1992, latex paint was formulated with mercury (Hg) as phenylmercuric acetate (PMA). Hg vaporizes reducing its content, and lead (Pb) is stable and remains unchanged. The objective of this study is to describe the content of Hg and Pb in existing paint coatings. Read More
Clin Pediatr (Phila) 2007 Nov 19;46(9):844-6. Epub 2007 Jul 19.
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9063, USA.
The incidence of mercury intoxication has decreased considerably because of stricter public health regulations. However, it has not been completely eliminated and should be considered in a child with unexplained tachycardia, hypertension, mood changes, weight loss, and acrodynia. Mercury intoxication can be difficult to differentiate from pheochromocytoma and Kawasaki's disease. Read More
Pediatr Nephrol 2007 Jun 20;22(6):903-6. Epub 2007 Feb 20.
Department of Pediatrics, Assaf Harofeh Medical Center, Zerifin, 70300, Israel.
A 2-year-old girl presented with hypertension, anorexia and vomiting, restlessness, insomnia and acrodynia. Her blood pressure upon arrival was 145/98 mmHg. Ultrasound of the abdomen, CT scan of chest, abdomen and pelvis, and echocardiogram, were normal. Read More
Clin Toxicol (Phila) 2006 ;44(1):85-8
Pediatrics Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mercury vapor poisoning is a serious and potentially fatal problem. Neurological manifestations involving the central nervous system are seen with chronic mercury intoxication. We present the case of a 10-year-old child who demonstrated acrodynia, seizures, and visual impairment following 20 days of exposure to elemental mercury at home. Read More
Pediatr Dermatol 2004 May-Jun;21(3):254-9
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
A3-year-old boy presented to the Hospital for Sick Children with systemic symptoms and oropharyngeal and peripheral extremity changes suggestive of Kawasaki disease. He was found to have severe hypertension. Investigation for a catecholamine-secreting tumor was negative. Read More
Toxicol Appl Pharmacol 2004 Jan;194(2):169-79
Molecular and Immunological Pathology (AIR), Department of Molecular and Clinical Medicine, Linköping University, SE-581 85 Linköping, Sweden.
The organic compound ethylmercurithiosalicylate (thimerosal), which is primarily present in the tissues as ethylmercury, has caused illness and several deaths due to erroneous handling when used as a disinfectant or as a preservative in medical preparations. Lately, possible health effects of thimerosal in childhood vaccines have been much discussed. Thimerosal is a well-known sensitizing agent, although usually of no clinical relevance. Read More
Eur J Pediatr 2003 Jul 16;162(7-8):559-561. Epub 2003 May 16.
Department of Paediatrics, University Children's Hospital, Zürich, Switzerland.
CMAJ 2003 Jan;168(2):201
Department of Pediatrics Hospital for Sick Children Toronto, ON.
Med Lav 2002 May-Jun;93(3):139-47
Environmental Geochemistry Research Group, Department of Environmental Science and Technology, Imperial College of Science, Technology & Medicine, Prince Consort Road, London SW7 2BP, UK.
Objectives: This paper was given as a keynote address at the conference on The Assessment of the Effects Due to Low Doses of Inorganic Mercury following Environmental and Occupational Exposures: Human and in vitro Studies on the Specific Mechanisms of Toxicity in Gargnano, Italy, in September 2001.
Methods: The most relevant literature over the past 40 years has been reviewed, and in particular, the proceedings of the World Health Organisation conferences on the health effects of inorganic and organic mercury exposure have been considered.
Results: In an uncontaminated environment the general population is exposed to mercury vapour from the atmosphere and from dental amalgam, while the diet, mainly from fish, is the principal source for methyl mercury absorption. Read More
Arch Dis Child 2002 Jun;86(6):453
Hist Sci Med 1998 ;32(3):279-86
Born in 1820 Joseph-Desire Tholozan joined in 1841 as "chirurgien sous-aide auxiliaire" the French military Health Service, being still a medical student in Marseille where the School of Medicine was directed by his uncle F. Cauviere. He was later appointed at the hospital of Bastia, obtained his M. Read More
Acta Paediatr 2001 May;90(5):593-4
J Am Acad Dermatol 2000 Jul;43(1 Pt 1):81-90
Department of Medicine (Dermatology), Vanderbilt University, Nashville, TN, USA.
Human contact with mercury has been ongoing for centuries and was previously considered a legitimate means of treating different cutaneous and systemic conditions. Toxicity from this heavy metal may occur from exposure to elemental, inorganic, and organic forms of mercury. This article outlines the signs and symptoms of mercury poisoning and the different clinical conditions with assorted cutaneous findings. Read More
Pediatrics 2000 Mar;105(3):E34
Department of Pediatric Nephrology, Michigan State University Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA.
Two children in the same household with symptomatic arterial hypertension simulating pheochromocytoma were found to be intoxicated with elemental mercury. The first child was a 4-year-old boy who presented with new-onset seizures, rash, and painful extremities, who was found to have a blood pressure of 171/123 mm Hg. An extensive investigation ensued. Read More
J R Soc Med 1999 Sep;92(9):478-81
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998 Apr;85(4):349
Bull Soc Pathol Exot 1998 ;91(1):104-8
Recherche honoraire au CNRS, Paris.
Born in 1820 from French parents in Diego Garcia, an islet then linked to Mauritius where he started in Port-Louis his school years, Joseph Désiré Tholozan was an original personality. He undertook medical studies in France (M. D. Read More
Soc Hist Med 1997 Aug;10(2):291-304
Wellcome Institute for the History of Medicine, London.
This paper explores the social and medical history and context of pink disease (acrodynia), a serious disease of infants and young children that baffled the medical world during the first half of the twentieth century until it was shown to be caused by mercury poisoning. In the English-speaking world the commonest source of the mercury was teething powders, which were widely available and advertised with increasing sophistication. Efforts to control them (such as the BMJ's campaign against 'Secret Remedies') were as yet unsuccessful. Read More
Int Arch Occup Environ Health 1997 ;70(2):101-6
Department of Occupational Medicine, Sahlgrenska University Hospital, Göteborg, Sweden.
Unlabelled: Inorganic mercury may cause immunologically mediated disease: e.g., glomerulonephritis, acrodynia, and contact allergy. Read More
Met Ions Biol Syst 1997 ;34:321-70
BIBRA Toxicology International, Carshalton, Surrey, UK.
J Hist Neurosci 1996 Dec;5(3):265-73
The authors present a case of Morvan's fibrillary chorea. We compare this observation with cases in the past such as the "mal des ardents", the plague of Athens, acrodynia and the epidemic of Pont St Esprit which were all characterized clinically by pain, burning sensations, hallucinations and insomnia. Since aetiological aspects remain uncertain, the similarity in clinical observations establishes a close relationship between the "mal des ardents" and the clinical features of our patient. Read More
BMJ 1996 Jul;313(7048):44
J Mal Vasc 1996 ;21(2):84-7
Service de Médecine vasculaire et d'Hypertension artérielle, Hôpital Saint-Joseph, Paris.
The differential diagnosis of erythermalgia is sometimes complicated by the absence of consensus on proposed diagnostic criteria. Unwarranted diagnosis can result from any clinical situation leading to burning sensations in the limbs. This can occurs in patients with peripheral neuropathies who often experience dysesthesia when going to bed when the legs are under the covers; in such cases, redness and local warmth are missing. Read More
Pediatr Dermatol 1995 Sep;12(3):215-9
Department of Medicine, Medical College of Ohio, Toledo 43699, USA.
Generalized anhidrosis with heat collapse, painful fingers, and angiokeratomas were the presenting signs in a 23-year-old man who was shown by enzyme studies and electron microscopy to have Fabry disease. His 6-year-old brother had the early diagnostic findings of episodic painful fingers, heat intolerance, and retroauricular telangiectasia. Both had an absence of alpha-galactosidase. Read More
Eur J Pediatr 1995 Jul;154(7):585-6
Akademie für Kinderheilkunde und Jugendmedizin, Kinderhospital, Osnabrück, Germany.
Arch Pediatr 1995 Jan;2(1):43-6
Service de pédiatrie R, hôpital Gatien-de-Clocheville, Tours, France.
Background: Mercury poisoning is a rare cause of hypertension in children. Urinary excretion sometimes remains low despite severe clinical intoxication.
Case Report: A 32 month-old girl was admitted with hypertension, tachycardia, apathy, irritability and excessive sweating. Read More
J Toxicol Clin Toxicol 1995 ;33(5):449-55
Department of Preventive Medicine and Environmental Health, University of Iowa, Iowa City 52242-1100, USA.
Three cases of severe mercury toxicity occurring within a family are reported. Two cases of thrombocytopenia occurred in this family and represent the second such report in the literature of an association between elemental mercury toxicity and thrombocytopenia. Three of the children presented with a combination of dermatologic and neurologic manifestations reminiscent of acrodynia or pink disease. Read More