818 results match your criteria Acrodermatitis Enteropathica

Impact of Zinc Transport Mechanisms on Embryonic and Brain Development.

Nutrients 2022 Jun 17;14(12). Epub 2022 Jun 17.

Department of Pharmacology, Rutgers-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

The trace element zinc (Zn) binds to over ten percent of proteins in eukaryotic cells. Zn flexible chemistry allows it to regulate the activity of hundreds of enzymes and influence scores of metabolic processes in cells throughout the body. Deficiency of Zn in humans has a profound effect on development and in adults later in life, particularly in the brain, where Zn deficiency is linked to several neurological disorders. Read More

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Secondary acrodermatitis enteropathica-like skin findings in a case of methylmalonic acidemia.

Pediatr Dermatol 2022 Jun 11. Epub 2022 Jun 11.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.

Methylmalonic acidemia (MMA) is an autosomal recessive genetic disorder caused by decreased activity of methylmalonyl-CoA mutase or metabolic disturbance of its coenzyme cobalamin, cutaneous manifestations are rare clinical signs in this disease. Herein, we describe a Chinese boy with MMA fed with a formula lacking branched-chain amino acids presenting with erythroderma and acrodermatitis enteropathica-like rash, a homozygous nonsense mutation c.742C>T (p. Read More

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Heterologous Expression of Full-Length and Truncated Human ZIP4 Zinc Transporter in .

Biomolecules 2022 May 21;12(5). Epub 2022 May 21.

Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.

The human (h) transporter hZIP4 is the primary Zn importer in the intestine. hZIP4 is also expressed in a variety of organs such as the pancreas and brain. Dysfunction of hZIP4 can result in the Zn deficiency disease acrodermatitis enteropathica (AE). Read More

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Acrodermatitis enteropathica-like eruption.

JAAD Case Rep 2022 Jun 25;24:20-23. Epub 2022 Mar 25.

Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat, Morocco.

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Transient Symptomatic Zinc Deficiency: An Overlooked Diagnosis in Acrodermatitis Enteropathica like Eruption in an Exclusively Breastfed Preterm Infant.

Oman Med J 2022 Mar 22;37(2):e364. Epub 2022 Mar 22.

Department of Pediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

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Oral adverse events due to zinc deficiency after pancreaticoduodenectomy requiring continuous intravenous zinc supplementation: a case report and literature review.

BMC Oral Health 2022 03 3;22(1):52. Epub 2022 Mar 3.

Faculty of Dental Medicine, Oral Diagnosis and Medicine, Hokkaido University, Sapporo, Japan.

Background: Zinc is mainly absorbed in the duodenum and proximal jejunum, which are removed during pancreaticoduodenectomy (PD). Little is known about the adverse oral events and skin disorders caused by zinc deficiency after PD. Herein, we reviewed studies on the development of zinc deficiency after PD and reported about a patient with zinc deficiency after PD who required home intravenous zinc replacement. Read More

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Case of Olmsted Syndrome with Essential Thrombocytosis Misdiagnosed as Acrodermatitis Enteropathica.

Indian J Dermatol 2021 Sep-Oct;66(5):574

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Olmsted syndrome is a rare genodermatosis. Palmoplantar keratoderma and periorificial keratodermic plaques are the most important clinical findings. Additional findings associated with a large number of systems may accompany such as teeth, nail deformities, alopecia, mental retardation, and bone-joint anomalies. Read More

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January 2022

[Diagnosis of a rare and severe inflammatory bowel disease in an infant with peri-orificial ulcerations].

Ann Pathol 2021 Dec 31. Epub 2021 Dec 31.

Institut médicolégal de Marseille, hôpital de la Timone-Adultes, 264, rue Saint-Pierre, 13385 Marseille cedex 5, France.

We report the case of an infant aged 8 and a half months, who had an apparent life-threatening event and died despite optimal resuscitation management. The medical history was marked by mild symptoms, mainly feeding difficulties and progressively settling skin lesions. Parents were related (first cousins) and the patient had two healthy older sisters. Read More

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December 2021

Zinc ionophores: chemistry and biological applications.

J Inorg Biochem 2022 03 9;228:111691. Epub 2021 Dec 9.

Dipartimento di Scienze Chimiche, Università degli Studi di Catania, v.le A. Doria 6, 95125 Catania, Italy. Electronic address:

Zinc can play a pathophysiological role in several diseases and can interfere in key processes of microbial growth. This evidence justifies the efforts in applying Zinc ionophores to restore Zinc homeostasis and treat bacterial/viral infections such as coronavirus diseases. Zinc ionophores increase the intracellular concentration of Zinc ions causing significant biological effects. Read More

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Severe de novo pustular psoriasiform immune-related adverse event associated with nivolumab treatment for metastatic esophageal adenocarcinoma.

J Cutan Pathol 2022 May 22;49(5):472-481. Epub 2021 Dec 22.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Breakthrough targeted therapies have produced significant improvements in survival for cancer patients, but have a propensity to cause cutaneous immune-related adverse events (irAEs). Psoriasiform irAEs, representing about 4% of dermatologic toxicities associated with immune checkpoint inhibitor (ICI) therapy, are usually mild, occur in older patients and present as an exacerbation of existing psoriasis after several doses of ICI therapy. We report a case of a 58-year-old woman with metastatic esophageal adenocarcinoma and no prior history of psoriasis who developed a pustular psoriasiform irAE, beginning 3 days after initiation of nivolumab and progressing to confluent erythroderma with pustules over 2 weeks despite topical steroid use. Read More

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Novel nonsense mutation in the SLC39A4 gene in a Japanese boy with mild acrodermatitis enteropathica.

J Dermatol 2021 Dec 8;48(12):e602-e603. Epub 2021 Oct 8.

Department of Dermatology, Gifu University Graduate School of Medicine, Gifu, Japan.

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December 2021

A Missense Variant in in a Litter of Turkish Van Cats with Acrodermatitis Enteropathica.

Genes (Basel) 2021 08 25;12(9). Epub 2021 Aug 25.

Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland.

In a litter of Turkish Van cats, three out of six kittens developed severe signs of skin disease, diarrhea, and systemic signs of stunted growth at 6 weeks of age. Massive secondary infections of the skin lesions evolved. Histopathological examinations showed a mild to moderate hyperplastic epidermis, covered by a thick layer of laminar to compact, mostly parakeratotic keratin. Read More

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Acquired Zinc Deficiency Mimicking Acrodermatitis Enteropathica in a Breast-Fed Premature Infant.

Pediatr Rep 2021 Aug 1;13(3):444-449. Epub 2021 Aug 1.

Department of Pediatrics, Hôpital Universitaire des Enfants Reine Fabiola, Université Libre de Bruxelles, Avenue Jean Joseph Crocq 15, 1020 Brussels, Belgium.

We present a case of a transient acquired zinc deficiency in a breast-fed, 4-month-old-male prematurely born infant, with acrodermatitis enteropathica-like symptoms such as crusted, eroded, erythemato-squamous eruption in periorificial and acral patterns. The laboratory investigations showed low zinc levels in the infant's and the mother's serum and in the mother's milk; genetic analysis did not show any mutation in the gene, involved in acrodermatitis enteropathica. Acquired zinc deficiency is often found in premature infants because of their increased requirement, the low serum and milk zinc levels in breastfeeding women being also an important risk factor, as in this case. Read More

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Trichoscopy in acrodermatitis enteropathica.

Int J Dermatol 2022 Apr 17;61(4):480-483. Epub 2021 Aug 17.

Dermatology Department, Hospital de Clínicas de Porto Alegre, Brazil.

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Acrodermatitis enteropathica with ocular manifestations.

BMJ Case Rep 2021 Aug 5;14(8). Epub 2021 Aug 5.

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

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Therapeutic Use of Trace Elements in Dermatology.

Altern Ther Health Med 2021 Jul 16. Epub 2021 Jul 16.

Trace elements (microminerals) play a role in many physiological functions, including hormone production and cellular growth. However, their importance in diagnosing and treating dermatologic disease has not been well examined. In this review, we discuss the functions, sources, and recommended requirements of each micromineral. Read More

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A Case of Annular Epidermolytic Ichthyosis Resulting from a de Novo Mutation, p.I479T, in Gene.

Indian J Dermatol 2021 Mar-Apr;66(2):224

Department of Dermatology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

We report a case of annular epidermolytic ichthyosis (AEI) resulting from gene mutation. AEI is a rare autosomal dominantly inherited cornification disorder and is a distinct phenotypic variant of bullous congenital ichthyosiform erythroderma. Blisters and erosions in AEI are widespread; hence, initially, it is sometimes mistaken with epidermolysis bullosa, acrodermatitis enteropathica, and staphylococcal scalded skin syndrome. Read More

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Acquired Acrodermatitis Enteropathica in a 28-Year-Old Male with Type 1 Diabetes.

Case Rep Dermatol Med 2021 25;2021:5572583. Epub 2021 May 25.

University of Zambia School of Medicine, Lusaka, Zambia.

Acrodermatitis enteropathica (AE) is a rare disorder arising from inherited or acquired zinc deficiency. It is mainly characterized by acral dermatitis, periorificial dermatitis, alopecia, and gastrointestinal symptoms in the form of diarrhea. There are many complications of AE including local and systemic infections that may develop as a result of untreated AE. Read More

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Acrodermatite entéropathique chez un garçon de 3 mois.

CMAJ 2021 04;193(17):E627-E628

Université de Calgary (Leung), Hôpital pour enfants de l'Alberta (Leung), Calgary, Alb.; Institut de pédiatrie (Leong), Hôpital général de Kuala Lumpur, Kuala Lumpur, Malaisie; Département de dermatologie et des sciences dermatologiques (Lam), Université de la Colombie-Britannique, Hôpital pour enfants de la Colombie-Britannique (Lam), Vancouver, C.-B.

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Acute onset of blisters in an infant with acrodermatitis enteropathica: A case report.

SAGE Open Med Case Rep 2021 8;9:2050313X20984119. Epub 2021 Apr 8.

Department of Dermatology, Dalhousie University, Halifax, NS, Canada.

We represent a pediatric case of the congenital disorder caused by zinc malabsorption, acrodermatitis enteropathica, presenting with acute onsetof blisters. Although blisters can be seen in this condition, it is not always a key feature and can therefore be overlooked when considering a differential diagnosis of acute blistering in infancy. We therefore review the common and less common features of this cutaneous eruption as well as provide an extensive differential diagnosis for acute blistering in infancy. Read More

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Zinc transporter mutations linked to acrodermatitis enteropathica disrupt function and cause mistrafficking.

J Biol Chem 2021 Jan-Jun;296:100269. Epub 2021 Jan 8.

Department of Chemistry, Michigan State University, East Lansing, Michigan, USA; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan, USA. Electronic address:

ZIP4 is a representative member of the Zrt-/Irt-like protein (ZIP) transporter family and responsible for zinc uptake from diet. Loss-of-function mutations of human ZIP4 (hZIP4) drastically reduce zinc absorption, causing a life-threatening autosomal recessive disorder, acrodermatitis enteropathica (AE). These mutations occur not only in the conserved transmembrane zinc transport machinery, but also in the extracellular domain (ECD) of hZIP4, which is only present in a fraction of mammalian ZIPs. Read More

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Acquired acrodermatitis enteropathica from a ketogenic diet.

JAAD Case Rep 2021 Mar 28;9:75-77. Epub 2021 Jan 28.

University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii.

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Acrodermatitis enteropathica in a 3-month-old boy.

CMAJ 2021 Feb;193(7):E243

University of Calgary (Leung); Alberta Children's Hospital (Leung), Calgary, Alta.; Pediatric Institute (Leong), Kuala Lumpur General Hospital, Kuala Lumpur, Malaysia; Department of Dermatology and Skin Sciences (Lam), University of British Columbia; BC Children's Hospital (Lam), Vancouver, BC.

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February 2021

Dermatological Manifestations in Inflammatory Bowel Diseases.

J Clin Med 2021 Jan 19;10(2). Epub 2021 Jan 19.

Gastroenterology Unit, Department of Biomedical and Clinical Sciences, "L.Sacco" Hospital, 20157 Milano, Italy.

Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature on the dermatologic manifestations occurring in patients with inflammatory bowel diseases has been reviewed. Read More

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January 2021

Acrodermatitis Enteropathica: A Case Report.

Oman Med J 2020 Nov 23;35(6):e201. Epub 2020 Nov 23.

Ministry of Health, Muscat, Oman.

Acrodermatitis enteropathica is a rare autosomal recessive disease caused by a genetic mutation leading to zinc deficiency. Clinical manifestation includes skin lesions, diarrhea, and alopecia. We report the case of a two-month-old girl, admitted with erythematous scaly lesions in the neck and vesiculopustular lesions in the perioral region, associated with alopecia and diarrhea. Read More

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November 2020

Acquired Acrodermatitis Enteropathica.

Am J Med 2021 01 13;134(1):e2-e3. Epub 2020 Oct 13.

Department of Internal Medicine, Saint Vincent Hospital, Worcester, Mass.

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January 2021

Transient Symptomatic Zinc Deficiency Resembling Acrodermatitis Enteropathica in a Full-Term Breastfed Infant.

Indian J Pediatr 2021 03 6;88(3):292-293. Epub 2020 Oct 6.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

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Dermatological Manifestations in Pediatric Inflammatory Bowel Disease.

Medicina (Kaunas) 2020 Aug 23;56(9). Epub 2020 Aug 23.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Background and Objectives Over the last years, inflammatory bowel disease (IBD) has been reported on a high incidence in pediatric populations and has been associated with numerous extraintestinal manifestations, making its management a real challenge for the pediatric gastroenterologist. Dermatological manifestations in IBD are either specific, related to the disease activity or treatment-associated, or non-specific. This literature review aims to identify and report the dermatological manifestations of IBD in children, the correlation between their appearance and the demographical characteristics, the relationship between these lesions and disease activity, and to highlight the impact of dermatological manifestations on an IBD treatment regime. Read More

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