747 results match your criteria Acrodermatitis Enteropathica
Clin Case Rep 2018 Jun 14;6(6):1048-1050. Epub 2018 Apr 14.
Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER São Miguel Island, Azores Portugal.
Methylmalonic aciduria children must follow an adequate diet with low protein intake and should be regularly monitored to prevent complications. Although skin lesions like acrodermatitis enteropathica are rare in this disease, their appearance should be correlated with possible low plasma isoleucine level and it can be a sign of decompensation. Read More
Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.
Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York. vsharon@ northwell.edu.
Acquired zinc deficiency can develop as a consequence of poor nutritional intake or from dependence on total parenteral nutrition. Acquired zinc deficiency dermatitis classically manifests with erosions and scaly plaques in a periorificial and acral distribution. We present a case of a woman on parenteral nutrition who presented with bullous acrodermatitis mimicking pemphigus foliaceus histopathologically. Read More
Nutrients 2018 Feb 16;10(2). Epub 2018 Feb 16.
Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo 142-8555, Japan.
The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Read More
Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.
The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More
Rev Paul Pediatr 2018 Jan 15. Epub 2018 Jan 15.
Universidade de São Paulo, Ribeirão Preto, São Paulo, Brasil.
Objective: To report a case of acrodermatitis enteropathica, a rare disease with autosomal recessive inheritance.
Case Description: An 11-month-old boy was presenting symmetrical erythematous and yellowish-brownish crusted lesions on his face, feet, hands and knees, intermittent diarrhea, fever, and recurrent infections since the age of six months. He was thin and had scarce hair on the scalp. Read More
Bol Med Hosp Infant Mex 2017 Jul - Aug;74(4):295-300. Epub 2017 Jul 5.
Servicio de Infectología Pediátrica, Centro Médico Nacional 20 de Noviembre, ISSSTE, Ciudad de México, México.
Introduction: Acrodermatitis enteropathica is a low-incidence disease due to inherited or acquired zinc deficiency. It is characterized by acral dermatitis, alopecia, diarrhea and growth retardation. The dermatological condition may mimic a cutaneous fungal infection or other pathogen-related skin diseases. Read More
Transl Sci Rare Dis 2017 Dec 18;2(3-4):101-139. Epub 2017 Dec 18.
Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.
Trace elements are chemical elements needed in minute amounts for normal physiology. Some of the physiologically relevant trace elements include iodine, copper, iron, manganese, zinc, selenium, cobalt and molybdenum. Of these, some are metals, and in particular, transition metals. Read More
Clin Exp Dermatol 2018 Apr 15;43(3):315-318. Epub 2018 Jan 15.
Department of Dermatology, St George's Healthcare NHS Trust, London, UK.
Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Read More
Cutis 2017 11;100(5):E4-E6
Division of Dermatology, David Geffen School of Medicine, University of California Los Angeles, USA.
Cureus 2017 Sep 8;9(9):e1667. Epub 2017 Sep 8.
Internal Medicine, University of Central Florida College of Medicine.
We present a case of severe acquired acrodermatitis enteropathica in a vegan adult female with multiple underlying comorbidities. Acquired acrodermatitis enteropathica or zinc-deficiency dermatitis is the most common diagnosis than many practitioners realize with up to 10% of the patients in developed nations with the risk of zinc deficiency. The condition can be difficult to diagnose due to many similarly-presenting conditions. Read More
BMJ Case Rep 2017 Aug 2;2017. Epub 2017 Aug 2.
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. Read More
Biometals 2017 Oct 17;30(5):643-661. Epub 2017 Jul 17.
WG Cellular Neurobiology and Neuro-Nanotechnology, Department of Biological Sciences, University of Limerick, Limerick, Ireland.
Zn is essential for growth and development. The bioavailability of Zn is affected by several factors such as other food components. It is therefore of interest, to understand uptake mechanisms of Zn delivering compounds to identify ways to bypass the inhibitory effects of these factors. Read More
Case Rep Dermatol 2017 Jan-Apr;9(1):69-73. Epub 2017 Mar 17.
Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Necrolytic acral erythema (NAE) is a distinctive skin disorder. The exact cause and pathogenesis is still unclear. Most studies report an association of NAE with hepatitis C virus (HCV) infection. Read More
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2017 Jun;34(3):387-389
Department of Dermatology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 637000, China.
Objective: To detect pathogenic mutation of the SLC39A4 gene in a male patient with acrodermatitis enteropathica (AE).
Methods: Peripheral venous blood sample and clinical data from the patient and his parents were collected. One hundred unrelated healthy individuals were recruited as controls. Read More
BMC Dermatol 2017 May 18;17(1). Epub 2017 May 18.
Department of Dermatology, Johns Hopkins University School of Medicine, 1550 Orleans Street, Koch CRB II, Unit 206, Baltimore, MD, 21231, USA.
Background: Acrodermatitis enteropathica (AE) is a rare dermatitis secondary to zinc deficiency most commonly seen as an inherited disease in infants. In the last decade, increased number of reports have been published on the acquired form that presents in adulthood. Unlike its inherited counterpart, acquired AE (AAE) is often secondary to underlying pathologic or iatrogenic etiologies that interfere with nutritional absorption, such as inflammatory bowel disease or alcoholism. Read More
J Dermatol Case Rep 2016 Dec 31;10(4):65-67. Epub 2016 Dec 31.
Department of Dermatology, College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Background: Acrodermatitis enteropathica (AE) is a rare autosomal recessive metabolic disorder. First described by Brandt in 1936 and was named by Danbolt. A mutation in the SLC39A4 gene on chromosome 8 q24. Read More
Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More
Transplant Proc 2017 Apr;49(3):609-612
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Acrodermatitis enteropathica syndrome (AE) is a clinical entity that results in severe zinc deficiency. It can be genetic or acquired. Acquired AE has been reported in patients with chronic liver disease, malabsorption syndrome, sickle cell anemia, and chronic renal failure. Read More
Am J Dermatopathol 2017 Jun;39(6):428-432
*Department of Dermatology, University of the Ryukyus, Okinawa, Japan; †Department of Dermatology, Tone-chuo Hospital, Numata, Japan; ‡Department of Dermatology, Gunma University, Maebashi, Japan; §Department of Dermatology, Wakayama Medical University, Wakayama, Japan; ¶Department of Dermatology, Nagasaki University, Nagasaki, Japan; and ‖Department of Dermatology, Saitama Medical University Saitama Medical Center, Kawagoe, Japan.
Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. Read More
Am J Clin Dermatol 2017 Jun;18(3):343-354
Department of Dermatology, State University of New York Downstate Medical Center, 10 West, 800 Poly Place, Brooklyn, NY, 11203, USA.
Perianal lesions in children are common reasons for dermatology clinic visits and a well-defined approach to diagnosis and management is helpful to the practicing clinician. In this article, we review and update various etiologies of perianal lesions in the pediatric population, including infectious, papulosquamous, vascular, and neoplastic. We provide a standard initial approach to diagnosis and updates on current management. Read More
Int J Dermatol 2017 May 10;56(5):e97-e100. Epub 2017 Feb 10.
Infection and Immunity Department, Medical school, University of Sheffield, Sheffield, UK.
Clin Pediatr (Phila) 2018 Jan 5;57(1):99-102. Epub 2017 Jan 5.
1 University Hospital Erlangen, Erlangen, Germany.
J Invest Dermatol 2017 Apr 7;137(4):874-883. Epub 2016 Dec 7.
Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
Acrodermatitis enteropathica is an autosomal recessive disorder characterized by scaly eczematous dermatosis accompanied by alopecia and diarrhea. Various mutations in the SLC39A4 gene (ZIP4), which encodes a zinc transporter, are responsible for this disorder. However, the molecular mechanism underlying the involvement of ZIP4 in the pathogenesis of this condition has yet to be established. Read More
Paediatr Int Child Health 2016 Feb 26;36(1):72-5. Epub 2014 Dec 26.
Department of Paediatrics, SCB Medical College , Cuttack.
Zinc deficiency in patients with coeliac disease (CD) may result either from cumulative loss of insoluble zinc complexes or impaired zinc absorption because of damaged intestinal epithelial cell membrane. Zinc deficiency in CD is mild to moderate, though severe deficiency can occur in refractory or chronic CD cases with poor response to gluten-free diet (GFD). A boy aged 19 months presented with persistent diarrhoea, was diagnosed with CD, and developed severe zinc deficiency with acrodermatitis enteropathica-like disease while on GFD and zinc supplementation. Read More
Indian Pediatr 2016 Aug;53(8):738-40
Departments of Neonatology, *Pediatrics and #Clinical Genetics Unit,Christian Medical College, Vellore, Tamilnadu, India. Correspondence to: Dr Benjamin Ross, Department of Neonatology, Christian Medical College, Vellore 632 004, Tamilnadu, India.
Background: Special diet with restricted branched-chain-amino-acids used for treating maple syrup urine disease can lead to specific amino acid deficiencies.
Case Characteristics: We report a neonate who developed skin lesions due to isoleucine deficiency while using specialised formula.
Intervention/outcome: Feeds were supplemented with expressed breast milk. Read More
Nihon Rinsho 2016 Jul;74(7):1234-8
Adequate intake of zinc from the daily diet is indispensable to maintain health. However, the dietary zinc content often fails to fulfill the recommended daily intake, leading to zinc deficiency and also increases the risk of developing chronic diseases, particularly in elderly individuals. Therefore, increased attention is required to overcome zinc deficiency and it is important to improve zinc nutrition in daily life. Read More
Nihon Rinsho 2016 Jul;74(7):1144-9
Abstract Acrodermatitis enteropathica(AE) is caused by inherited or acquired zinc deficiency. Cutaneous clinical manifestations observed in AE include characteristic dermatitis on acral, periorificial and anogenital areas through an unknown mechanism. Recently, we found that mice fed a zinc-deficient diet develop a severe irritant contact dermatitis that has the histological features of the skin inflammation seen in AE patients. Read More
Clin Exp Dermatol 2016 Aug 23;41(6):651-4. Epub 2016 Jun 23.
Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Acrodermatitis dysmetabolica (AD) is a rare, newly termed, and poorly understood disease that appears to be clinically similar to acrodermatitis enteropathica (AE). Both diseases are characterized by the triad of periorificial and acral dermatitis, diarrhoea, and alopecia. Unlike AE, which is caused by zinc deficiency, AD is caused by numerous metabolic disorders. Read More
Arch Biochem Biophys 2016 Dec 7;611:113-119. Epub 2016 Jun 7.
Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi, 409-3898, Japan.
Of all tissues, the skin has the third highest abundance of zinc in the body. In the skin, the zinc concentration is higher in the epidermis than in the dermis, owing to a zinc requirement for the active proliferation and differentiation of epidermal keratinocytes. Here we review the dynamics and functions of zinc in the skin as well as skin disorders associated with zinc deficiency, zinc finger domain-containing proteins, and zinc transporters. Read More
JAAD Case Rep 2016 May 14;2(3):193-5. Epub 2016 May 14.
University of South Florida Department of Dermatology, Tampa, Florida.
JAMA 2016 May 24-31;315(20):2223-4
Division of Infectious Diseases and International Health, Department of Medicine, Duke University School of Medicine, Durham, North Carolina2Duke Clinical Research Institute, Duke University, Durham, North Carolina.
Medicine (Baltimore) 2016 May;95(20):e3553
From the Pediatrics Department (NN, O-EF, VVL, AI, VS), "Gr. T. Popa" University of Medicine and Pharmacy; and "St Mary" Children Emergency Hospital (LC), Iasi, Romania.
Acrodermatitis enteropathica is a rare genetic autosomal recessive disorder, characterized by periorificial dermatitis, alopecia, and diarrhea. It is caused by mutations in the gene that encodes a membrane protein that binds zinc. We report a 14-month-old boy, admitted for erythematous, scaly and pustular lesions, initially located in the inguinal and perianal regions and on thighs, and very few erythematous lesions on the face. Read More
Cutis 2016 Mar;97(3):E3-5
Department of Medicine, Division of Dermatology, Vanderbilt University Medical Center, USA.
Int J Mol Sci 2016 Mar 4;17(3):336. Epub 2016 Mar 4.
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Around 3000 proteins are thought to bind zinc in vivo, which corresponds to ~10% of the human proteome. Zinc plays a pivotal role as a structural, catalytic, and signaling component that functions in numerous physiological processes. It is more widely used as a structural element in proteins than any other transition metal ion, is a catalytic component of many enzymes, and acts as a cellular signaling mediator. Read More
J Dermatol 2016 Aug 24;43(8):966-8. Epub 2016 Feb 24.
Department of Dermatology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Pediatr Dermatol 2016 Mar-Apr;33(2):e93-4. Epub 2016 Feb 9.
Princess Margaret Hospital, Perth, Western Australia, Australia.
Acrodermatitis dysmetabolica is an umbrella term encompassing the other metabolic causes of an erosive periorificial and acral dermatitis that mimics acrodermatitis enteropathica. Causes include acquired zinc, amino acid, biotin, and fatty acid deficiencies. We present the case of an exclusively breastfed, 2-month-old boy with known cystic fibrosis admitted with failure to thrive and erosive dermatitis. Read More
Dermatol Online J 2016 Nov 15;22(11). Epub 2016 Nov 15.
Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Nutritional deficiency is rare in developed countries, but can be acquired from decreased nutrient intake, reduced absorption, and increased gastrointestinal excretion. We report a patient with acquired acrodermatitis enteropathica (AE) who exhibited low plasma zinc levels and concurrent nutritional deficiencies (pyridoxine, selenium and fatty acids). Our patient had undergone Roux-en-Y gastric bypass 13 years prior to presentation. Read More
J Pediatr 2016 Mar 15;170:332-e1. Epub 2015 Dec 15.
Summa Akron City Hospital, Akron, Ohio.
J Dermatol 2016 Apr 12;43(4):456-7. Epub 2015 Dec 12.
Kushiro Red Cross Hospital, Hokkaido, Japan.
J Nutr Sci Vitaminol (Tokyo) 2015 ;61 Suppl:S44-6
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University.
Zinc nutrition is of special practical importance in infants and children. Poor zinc absorption causes zinc deficiency, which leads to a broad range of consequences such as alopecia, diarrhea, skin lesions, taste disorders, loss of appetite, impaired immune function and neuropsychiatric changes and growth retardation, thus potentially threatening life in infants and children. In addition to dietary zinc deficiency, inherited zinc deficiency, which rarely occurs, is found during the infant stage and early childhood. Read More
Int J Biochem Cell Biol 2015 Dec 13;69:11-9. Epub 2015 Oct 13.
School of Biological Sciences, Monash University, Victoria, Australia. Electronic address:
Dietary zinc is the principal source of zinc in eukaryotes, with its uptake and distribution controlled by a complex network of numerous membrane-spanning transport proteins. Dietary absorption is achieved by members of the SLC39A (ZIP) gene family, which encode proteins that are generally responsible for the movement of zinc into the cytosol. ZIP4 is thought to be the primary mammalian zinc uptake gene in the small intestine, with mutations in this gene causing the zinc deficiency disease Acrodermatitis enteropathica. Read More
J Dtsch Dermatol Ges 2015 Nov;13(11):1147-54
Department of Dermatology and Venereology, The Rudolfstiftung Hospital, Teaching Hospital of Vienna Medical University, Vienna, Austria.
Background And Objectives: Women who have undergone bariatric surgery are susceptible to nutritional deficiencies in subsequent pregnancies. We highlight the importance of dermatologists in the early recognition of cutaneous signs of malnutrition occurring in this specific clinical setting.
Patients And Methods: We compare clinical characteristics of two young women with dermatological signs of combined post-gestational nutritional deficiencies following Roux-en-Y gastric bypass surgery. Read More
Am J Gastroenterol 2015 Oct;110(10):1396
University of Missouri-Columbia, Columbia, Missouri, USA.
Eur J Hum Genet 2016 May 7;24(5). Epub 2015 Oct 7.
CHU de Nantes, Service de Génétique Médicale, Nantes, France.
Biochem J 2015 Dec 18;472(2):183-93. Epub 2015 Sep 18.
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
Dietary zinc deficiency puts human health at risk, so we explored strategies for enhancing zinc absorption. In the small intestine, the zinc transporter ZIP4 functions as an essential component of zinc absorption. Overexpression of ZIP4 protein increases zinc uptake and thereby cellular zinc levels, suggesting that food components with the ability to increase ZIP4 could potentially enhance zinc absorption via the intestine. Read More
Acta Derm Venereol 2016 Mar;96(3):424-5
Department of Dermatology, Allergology and Venerology, University Clinics Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Aust Fam Physician 2015 May;44(5):299-300
Rev Chil Pediatr 2015 Jan-Feb;86(1):52-5
Unidad de Dermatología Infantil, Hospital de Niños Dr. Exequiel González Cortés, Santiago, Chile.
Introduction: Cutaneous manifestations at the time of CF diagnosis are rare.
Objective: To describe the case of an infant with an unusual cutaneous presentation of cystic fibrosis.
Case Report: The case is presented of an infant with delayed physical growth at two months, and at the age of four months, presented with a skin rash and gray hair. Read More
Clin Dermatol 2015 Jul-Aug;33(4):414-9. Epub 2015 Apr 8.
Department of Dermatology, University of Connecticut Health Center, 21 South Road, Farmington, CT, 06030, USA. Electronic address:
The appropriate intake and metabolism of vitamins and minerals are critical to maintaining homeostasis. Imbalance in essential nutrients, either through dietary excess or deficiency or disorders in metabolism, can result in a spectrum of dermatologic and systemic manifestations. Certain nutrient deficiencies produce a characteristic pattern of cutaneous eruption. Read More