784 results match your criteria Acrodermatitis Enteropathica


Acrodermatitis Enteropathica as a Presentation of Cystic Fibrosis in an Infant.

Indian Pediatr 2020 Jun;57(6):573

Kanchi Kamakoti CHILDS Trust Hospital, Chennai, India.

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Acrodermatitis enteropathica: a hereditary form of zinc deficiency.

QJM 2020 May 22. Epub 2020 May 22.

Division of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, 2-13-22, Miyakojima-Hondori, Miyakojima, Osaka, Japan.

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http://dx.doi.org/10.1093/qjmed/hcaa176DOI Listing

Alopecia universalis-like hair loss in acrodermatitis enteropathica.

Clin Exp Dermatol 2020 May 19. Epub 2020 May 19.

Department of Dermatology, Leicester Royal Infirmary, Leicester, UK.

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http://dx.doi.org/10.1111/ced.14232DOI Listing

Necrolytic Acral Erythema: Current Insights.

Clin Cosmet Investig Dermatol 2020 5;13:275-281. Epub 2020 Apr 5.

Department of Dermatology, Venereology and Leprosy, SN Medical College, Bagalkote 587102, Karnataka, India.

Necrolytic acral erythema (NAE) is now considered as a distinct clinical entity. It clinically presents as well demarcated hyperpigmented papules and plaques with thick adherent scales distributed symmetrically over dorsum of feet. It usually develops in patients with Hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.2147/CCID.S189175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147628PMC

A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency.

Exp Dermatol 2020 Jun 23;29(6):556-561. Epub 2020 Apr 23.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

The SLC30A2 gene encodes zinc transporter ZnT2, which is indispensable for the transport of zinc into the breast milk in the mammary gland. Transient neonatal zinc deficiency (TNZD) is caused by a mutation in the maternal SLC30A2 gene and has a clinical presentation similar to that of acrodermatitis enteropathica (AE). We described the case of a Chinese infant who presented with AE-like lesions 10 days after birth. Read More

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http://dx.doi.org/10.1111/exd.14099DOI Listing

Acrodermatitis Enteropathica.

J Pediatr 2020 May 21;220:258-259. Epub 2020 Feb 21.

Department of Dermatology, Venereology and Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1016/j.jpeds.2020.01.017DOI Listing
May 2020
3.790 Impact Factor

Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature.

BMC Pediatr 2020 Jan 27;20(1):34. Epub 2020 Jan 27.

Dermatology Hospital of Southern Medical University, Guangzhou, China.

Background: Acrodermatitis enteropathica (AE) is a rare autosomal recessive hereditary skin disease caused by mutations in the SLC39A4 gene and is characterized by periorificial dermatitis, alopecia and diarrhoea due to insufficient zinc absorption. Only one of the three known sets of twins with AE has genetic information. This case reports the discovery of new mutation sites in rare twin patients and draws some interesting conclusions by analysing the relationship between genetic information and clinical manifestations. Read More

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http://dx.doi.org/10.1186/s12887-020-1942-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983971PMC
January 2020

Elucidating the H Coupled Zn Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica.

Int J Mol Sci 2020 Jan 22;21(3). Epub 2020 Jan 22.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.

Cellular Zn homeostasis is tightly regulated and primarily mediated by designated Zn transport proteins, namely zinc transporters (ZnTs; SLC30) that shuttle Zn efflux, and ZRT-IRT-like proteins (ZIPs; SLC39) that mediate Zn influx. While the functional determinants of ZnT-mediated Zn efflux are elucidated, those of ZIP transporters are lesser understood. Previous work has suggested three distinct molecular mechanisms: (I) HCO3 or (II) H coupled Zn transport, or (III) a pH regulated electrodiffusional mode of transport. Read More

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http://dx.doi.org/10.3390/ijms21030734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037870PMC
January 2020

Genomics-based treatment in a patient with two overlapping heritable skin disorders: Epidermolysis bullosa and acrodermatitis enteropathica.

Hum Mutat 2020 May 25;41(5):906-912. Epub 2020 Jan 25.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.

Next-generation sequencing (NGS) is helpful in diagnosing complex genetic disorders and phenotypes, particularly when more than one overlapping condition is present. From a large cohort of 362 families with clinical manifestations of skin and mucosal fragility, referred by several major medical centers, one patient was found by NGS to have two overlapping heritable skin diseases, recessive dystrophic epidermolysis bullosa (RDEB; COL7A1 mutations) and acrodermatitis enteropathica (AE; SLC39A4 mutations). The pathogenicity of the variants was studied at gene expression as well as ultrastructural and tissue levels. Read More

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http://dx.doi.org/10.1002/humu.23980DOI Listing
May 2020
5.144 Impact Factor

Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease.

ACG Case Rep J 2019 Sep 29;6(9):e00209. Epub 2019 Aug 29.

Division of Gastroenterology, Hackensack University (Palisades) Medical Center, North Bergen, NJ.

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http://dx.doi.org/10.14309/crj.0000000000000209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831137PMC
September 2019

[Cutaneous manifestations of nutritional deficiencies].

Rev Med Suisse 2019 Nov;15(672):2125-2130

Service de médecine interne, Département de médecine, CHUV, 1011 Lausanne.

In elderly or chronically ill patients, nutritional deficiencies are common and the presence of related skin lesions is not unusual. Recognition of such cutaneous involvement is important regarding the diagnosis essentially based on clinical elements. By using some clinical case reports, we will describe several pathologies related to nutritional deficiencies like scurvy, pellagra and acquired acrodermatitis enteropathica. Read More

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November 2019

Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis.

Case Rep Dermatol 2019 Sep-Dec;11(3):240-248. Epub 2019 Sep 10.

Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, Indonesia.

Acrodermatitis enteropathica (AcE) is a rare, autosomal recessive inherited disorder caused by mutation of the gene coding for zinc transport protein (ZIP 4). The disease appears during childhood especially in breastfeeding or post-breastfeeding infant. Eczema herpeticum refers to a disseminated skin infection of herpes simplex virus that usually leads to vesicular eruptions commonly seen on a background of atopic dermatitis (AD). Read More

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http://dx.doi.org/10.1159/000502509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6787433PMC
September 2019
50 Reads

Acquired Acrodermatitis Enteropathica.

JAMA Dermatol 2019 Aug 28. Epub 2019 Aug 28.

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1001/jamadermatol.2019.2342DOI Listing
August 2019
2 Reads

Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass.

BMJ Case Rep 2019 Aug 2;12(8). Epub 2019 Aug 2.

Department of Internal Medicine, School of Medicine, University of Florida, Gainesville, Florida, USA.

A 39-year-old woman with a history of Roux-en-Y gastric bypass (RYGB) surgery and alcohol use presented with a confluent erythematous rash involving the perineum spreading outward to the abdomen, thighs and lower back. She had angular cheilitis and glossitis. The rash was painful and blistering in scattered areas. Read More

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http://dx.doi.org/10.1136/bcr-2019-230605DOI Listing
August 2019
4 Reads

Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood.

Br J Dermatol 2019 11 1;181(5):e114. Epub 2019 Aug 1.

Beaumont Hospital, Department of Dermatology, Beaumont Road, Dublin, 9, Ireland.

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http://dx.doi.org/10.1111/bjd.18208DOI Listing
November 2019
1 Read

Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency.

Clin Exp Dermatol 2020 Mar 21;45(2):266-267. Epub 2019 Aug 21.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

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http://dx.doi.org/10.1111/ced.14053DOI Listing
March 2020
8 Reads

Overlapping dermatologic diagnoses in severe Crohn's disease with duel genetic mutations.

Int J Dermatol 2019 Nov 17;58(11):e214-e216. Epub 2019 Jun 17.

Department of Dermatology, University of Florida College of Medicine, Gainesville, FL, USA.

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http://dx.doi.org/10.1111/ijd.14520DOI Listing
November 2019
1 Read

Hypereosinophilic syndrome masquerading as acrodermatitis enteropathica.

Indian J Dermatol Venereol Leprol 2019 Jul-Aug;85(4):418-422

Department of Dermatology Venereology and Leprosy, Rajiv Gandhi Government General Hospital and Madras Medical College (Affiliated to The Tamil Nadu Dr. M.G.R Medical University) Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_607_17DOI Listing
February 2020
10 Reads

The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport.

Biochem J 2019 06 28;476(12):1791-1803. Epub 2019 Jun 28.

Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, U.S.A.

The Zrt-/Irt-like protein (ZIP) family mediates zinc influx from extracellular space or intracellular vesicles/organelles, playing a central role in systemic and cellular zinc homeostasis. Out of the 14 family members encoded in human genome, ZIP4 is exclusively responsible for zinc uptake from dietary food and dysfunctional mutations of ZIP4 cause a life-threatening genetic disorder, Acrodermatitis Enteropathica (AE). About half of the missense AE-causing mutations occur within the large N-terminal extracellular domain (ECD), and our previous study has shown that ZIP4-ECD is crucial for optimal zinc uptake but the underlying mechanism has not been clarified. Read More

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http://dx.doi.org/10.1042/BCJ20190108DOI Listing
June 2019
8 Reads

Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells.

J Vis Exp 2019 05 16(147). Epub 2019 May 16.

Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School;

Transition metals are essential micronutrients for organisms but can be toxic to cells at high concentrations by competing with physiological metals in proteins and generating redox stress. Pathological conditions that lead to metal depletion or accumulation are causal agents of different human diseases. Some examples include anemia, acrodermatitis enteropathica, and Wilson's and Menkes' diseases. Read More

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http://dx.doi.org/10.3791/59519DOI Listing
May 2019
25 Reads

Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition.

Pediatr Dermatol 2019 Jul 24;36(4):520-523. Epub 2019 May 24.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

Well-known causes of zinc deficiency, also referred to as acrodermatitis enteropathica (AE), include defects in intestinal zinc transporters and inadequate intake, but a rare cause of acquired zinc deficiency discussed here is an iatrogenic nutritional deficiency caused by parenteral nutrition administered without trace elements. While zinc-depleted parenteral nutrition causing dermatosis of acquired zinc deficiency was first reported in the 1990s, it is now again relevant due to a national vitamin and trace element shortage. A high index of suspicion may be necessary to diagnose zinc deficiency, particularly because early clinical findings are nonspecific. Read More

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http://dx.doi.org/10.1111/pde.13865DOI Listing
July 2019
8 Reads

50 Years Ago in The Journal of Pediatrics: Acrodermatitis Enteropathica: Defective Metabolism of Unsaturated Fatty Acids.

J Pediatr 2019 May;208:155

Department of Pediatrics, University College of Medical Sciences, Delhi, India.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476183159
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http://dx.doi.org/10.1016/j.jpeds.2018.11.007DOI Listing
May 2019
19 Reads

Biotin Is Required for the Zinc Homeostasis in the Skin.

Nutrients 2019 Apr 24;11(4). Epub 2019 Apr 24.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.

Patients with biotin deficiency present symptoms that are similar to those in patients with acrodermatitis enteropathica (inherent zinc deficiency). However, the association between biotin and zinc deficiency remains unknown. We have previously shown that epidermal keratinocytes of mice fed zinc-deficient (ZD) diets secreted more adenosine triphosphate (ATP) than those of mice fed zinc-adequate (ZA) diets and that epidermal Langerhans cells are absent in ZD mice. Read More

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http://dx.doi.org/10.3390/nu11040919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520690PMC
April 2019
10 Reads

Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica.

Clin Exp Dermatol 2019 Dec 13;44(8):933-936. Epub 2019 Apr 13.

Department of Dermatology, Dermatology Hospital of Southern Medical University, Guangzhou, Guangdong, China.

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http://dx.doi.org/10.1111/ced.13964DOI Listing
December 2019
6 Reads

Quantifying the Oligomeric State of hZIP4 on the Surface of Cells.

Biochemistry 2019 04 20;58(13):1705-1708. Epub 2019 Mar 20.

Department of Chemistry and Biochemistry , Worcester Polytechnic Institute , Worcester , Massachusetts 01609-2247 , United States.

The human (h) zinc transporter ZIP4 is expressed on the plasma membrane and functions to increase cytosolic zinc levels. Mutations in hZIP4 cause the disease acrodermatitis enteropathica. Dysfunction in the regulation of hZIP4 has also been indicated in solid tissue cancers, including pancreatic and prostate cancer. Read More

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http://dx.doi.org/10.1021/acs.biochem.9b00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163800PMC
April 2019
8 Reads

Zinc and skin: an update.

J Dtsch Dermatol Ges 2019 Jun 15;17(6):589-596. Epub 2019 Mar 15.

Department of Dermatology, Venereology and Allergology, University Medical Center, Würzburg, Germany.

The essential trace element zinc (Zn) plays a key role in the development, differentiation and growth of various human tissues. Zinc homeostasis is primarily regulated by two zinc transporter families (solute-linked carrier families, SLC). Disturbances in zinc metabolism may give rise to disorders that typically manifest themselves on the skin. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13811
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http://dx.doi.org/10.1111/ddg.13811DOI Listing
June 2019
27 Reads

Acquired acrodermatitis enteropathica secondary to sleeve gastrectomy.

Indian J Dermatol Venereol Leprol 2019 Mar-Apr;85(2):220-223

Department of Dermatology and Venerology, School of Medicine, Akdeniz University, Antalya, Turkey.

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http://www.ijdvl.com/text.asp?2019/85/2/220/250853
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http://dx.doi.org/10.4103/ijdvl.IJDVL_337_18DOI Listing
June 2019
8 Reads

Acrodermatitis enteropathica: the need for sustained high dose zinc supplementation.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

Department of Dermatology, JSS Medical College and Hospital, Mysore, Karanataka.

Acrodermatitis enteropathica (AE) is a rare congenital disorder owing to an abnormality with intestinal absorption and/or transportation of zinc. We describe two male siblings, who presented with evidence of both acute and chronic zinc deficiency, despite being diagnosed with AE very early in life. We wish to highlight the importance of sustained high-dose zinc supplementation and regular monitoring in AE cases. Read More

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December 2018
9 Reads

Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica?

Nutrients 2019 Jan 21;11(1). Epub 2019 Jan 21.

The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, 30 Royal Parade, Parkville, Victoria 3052, Australia.

Acrodermatitis enteropathica (AE) is a rare disease characterised by a failure in intestinal zinc absorption, which results in a host of symptoms that can ultimately lead to death if left untreated. Current clinical treatment involves life-long high-dose zinc supplements, which can introduce complications for overall nutrient balance in the body. Previous studies have therefore explored the pharmacological treatment of AE utilising metal ionophore/transport compounds in an animal model of the disease (conditional knockout (KO) of the zinc transporter, ), with the perspective of finding an alternative to zinc supplementation. Read More

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http://dx.doi.org/10.3390/nu11010206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356714PMC
January 2019
7 Reads

Acquired zinc deficiency in a renal transplant recipient with gastrointestinal tuberculosis responding promptly to oral correction.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1199-1202

Department of Dermatology, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India.

Zinc deficiency is an uncommon condition, known to occur in two forms: inherited type, known as Acrodermatitis enteropathies and the acquired type. Cutaneous clinical manifestations observed include characteristic dermatitis on acral, periorificial, and anogenital areas through an unknown mechanism. The patient had a combination of causes which lead to a state of zinc deficiency. Read More

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http://www.sjkdt.org/text.asp?2018/29/5/1199/243962
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http://dx.doi.org/10.4103/1319-2442.243962DOI Listing
November 2019
46 Reads

Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East.

Dermatol Res Pract 2018 7;2018:1284568. Epub 2018 Aug 7.

Department of Infection, Immunity and Cardiovascular Disease, The Medical School, University of Sheffield, Sheffield S10 2RX, UK.

We report a family from Tabuk, Saudi Arabia, previously screened for Acrodermatitis Enteropathica (AE), in which two siblings presented with typical features of acral dermatitis and a pustular eruption but differing severity. Affected members of our family carry a rare genetic variant, p.Gly512Trp in the SLC39A4 gene which encodes a zinc transporter; disease is thought to result from zinc deficiency. Read More

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http://dx.doi.org/10.1155/2018/1284568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6106946PMC
August 2018
19 Reads

Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition.

Dermatol Online J 2018 May 15;24(5). Epub 2018 May 15.

Department of Dermatology, University of California, Davis, California.

The original article was published on July19, 2017 and corrected on May 15, 2018. The revised version of the article includes a funding source for Dr. Maija Kiuru's participation in this case report, awarded by the National Cancer Institute, National Institutes of Health grant K12CA138464. Read More

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May 2018
14 Reads

Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition.

Cutis 2018 Jun;101(6):450-453

Department of Dermatology, University of Maryland School of Medicine, Baltimore, USA.

Acrodermatitis enteropathica (AE) is a rare autosomal-recessive disorder of zinc malabsorption, characterized by acral and periorificial dermatitis, alopecia, and diarrhea. Acquired AE is the result of decreased zinc intake, excessive zinc loss, or other malabsorptive processes. We present a case of a 54-year-old woman who developed characteristic skin lesions of acquired AE after zinc supplementation was removed from her total parenteral nutrition (TPN) solution. Read More

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June 2018
6 Reads

Acrodermatitis Enteropathica Presenting with Recurrent Diarrhea and Vomiting in an Infant Reluctant to Breastfeed, and a Peculiar Erythemato-Eczematous Eruption around the Oral and Anogenital Regions.

Skinmed 2018;16(3):205-207. Epub 2018 Jun 1.

Department of Pathology, University College of Medical Sciences, and Associated Guru Teg Bahadur Hospital, Shahdara, Delhi, India.

A 6-month-old, 4-kg, dehydrated girl, an Indian native, was admitted with recurrent episodes of diarrhea that had occurred since age 2 months. She had stopped breastfeeding. She had also had concomitant vomiting and loss of appetite. Read More

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October 2019
19 Reads

Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation.

Clin Case Rep 2018 Jun 14;6(6):1048-1050. Epub 2018 Apr 14.

Pediatric Department Hospital of Divino Espirito Santo of Ponta Delgada, EPER São Miguel Island, Azores Portugal.

Methylmalonic aciduria children must follow an adequate diet with low protein intake and should be regularly monitored to prevent complications. Although skin lesions like acrodermatitis enteropathica are rare in this disease, their appearance should be correlated with possible low plasma isoleucine level and it can be a sign of decompensation. Read More

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http://dx.doi.org/10.1002/ccr3.1509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986048PMC
June 2018
62 Reads

Nonspecific erythema and scaling of the palms in a 53-year-old woman.

J Dtsch Dermatol Ges 2018 May 16;16(5):632-634. Epub 2018 Apr 16.

Department of Dermatology, Jena University Hospital, Germany.

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http://doi.wiley.com/10.1111/ddg.13499
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http://dx.doi.org/10.1111/ddg.13499DOI Listing
May 2018
22 Reads

Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition.

Dermatol Online J 2017 Jul 15;23(7). Epub 2017 Jul 15.

Department of Dermatology, Hofstra Northwell School of Medicine, New Hyde Park, New York. vsharon@ northwell.edu.

Acquired zinc deficiency can develop as a consequence of poor nutritional intake or from dependence on total parenteral nutrition. Acquired zinc deficiency dermatitis classically manifests with erosions and scaly plaques in a periorificial and acral distribution. We present a case of a woman on parenteral nutrition who presented with bullous acrodermatitis mimicking pemphigus foliaceus histopathologically. Read More

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July 2017
20 Reads

The Role of the Slc39a Family of Zinc Transporters in Zinc Homeostasis in Skin.

Nutrients 2018 Feb 16;10(2). Epub 2018 Feb 16.

Division of Pathology, Department of Oral Diagnostic Sciences, School of Dentistry, Showa University, Tokyo 142-8555, Japan.

The first manifestations that appear under zinc deficiency are skin defects such as dermatitis, alopecia, acne, eczema, dry, and scaling skin. Several genetic disorders including acrodermatitis enteropathica (also known as Danbolt-Closs syndrome) and Brandt's syndrome are highly related to zinc deficiency. However, the zinc-related molecular mechanisms underlying normal skin development and homeostasis, as well as the mechanism by which disturbed zinc homeostasis causes such skin disorders, are unknown. Read More

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http://dx.doi.org/10.3390/nu10020219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852795PMC
February 2018
14 Reads

Zinc and Skin Disorders.

Nutrients 2018 Feb 11;10(2). Epub 2018 Feb 11.

Department of Dermatology, Faculty of Medicine, University of Yamanashi, Yamanashi 409-3898, Japan.

The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Read More

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http://www.mdpi.com/2072-6643/10/2/199
Publisher Site
http://dx.doi.org/10.3390/nu10020199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852775PMC
February 2018
24 Reads

ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS.

Rev Paul Pediatr 2018 Apr-Jun;36(2):238-241. Epub 2018 Jan 15.

Universidade de São Paulo, Ribeirão Preto, São Paulo, Brasil.

Objective: To report a case of acrodermatitis enteropathica, a rare disease with autosomal recessive inheritance.

Case Description: An 11-month-old boy was presenting symmetrical erythematous and yellowish-brownish crusted lesions on his face, feet, hands and knees, intermittent diarrhea, fever, and recurrent infections since the age of six months. He was thin and had scarce hair on the scalp. Read More

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http://dx.doi.org/10.1590/1984-0462/;2018;36;2;00010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038791PMC
January 2019
11 Reads

[Acrodermatitis enteropathica].

Bol Med Hosp Infant Mex 2017 Jul - Aug;74(4):295-300. Epub 2017 Jul 5.

Servicio de Infectología Pediátrica, Centro Médico Nacional 20 de Noviembre, ISSSTE, Ciudad de México, México.

Introduction: Acrodermatitis enteropathica is a low-incidence disease due to inherited or acquired zinc deficiency. It is characterized by acral dermatitis, alopecia, diarrhea and growth retardation. The dermatological condition may mimic a cutaneous fungal infection or other pathogen-related skin diseases. Read More

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http://dx.doi.org/10.1016/j.bmhimx.2017.05.002DOI Listing
May 2019
15 Reads

Disorders of metal metabolism.

Transl Sci Rare Dis 2017 Dec 18;2(3-4):101-139. Epub 2017 Dec 18.

Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA.

Trace elements are chemical elements needed in minute amounts for normal physiology. Some of the physiologically relevant trace elements include iodine, copper, iron, manganese, zinc, selenium, cobalt and molybdenum. Of these, some are metals, and in particular, transition metals. Read More

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http://dx.doi.org/10.3233/TRD-170015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764069PMC
December 2017
29 Reads

Acrodermatitis acidaemica.

Clin Exp Dermatol 2018 Apr 15;43(3):315-318. Epub 2018 Jan 15.

Department of Dermatology, St George's Healthcare NHS Trust, London, UK.

Methylmalonic acidaemia (MMA) is an inborn error of amino acid metabolism that may be associated with cutaneous manifestations mimicking other diagnoses, including staphylococcal scalded skin syndrome (SSSS), psoriasis and acrodermatitis enteropathica. Whether this is due to the underlying metabolic disorder itself or occurs as a consequence of dietary restriction has yet to be elucidated. Skin biopsies typically show histological features shared by a number of other metabolic disorders and nutritional deficiency-associated diseases. Read More

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http://dx.doi.org/10.1111/ced.13369DOI Listing
April 2018
16 Reads

Acrodermatitis enteropathica in a patient with short bowel syndrome.

Cutis 2017 11;100(5):E4-E6

Division of Dermatology, David Geffen School of Medicine, University of California Los Angeles, USA.

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November 2017
28 Reads

Acquired Acrodermatitis Enteropathica: A Case Study.

Cureus 2017 Sep 8;9(9):e1667. Epub 2017 Sep 8.

Internal Medicine, University of Central Florida College of Medicine.

We present a case of severe acquired acrodermatitis enteropathica in a vegan adult female with multiple underlying comorbidities. Acquired acrodermatitis enteropathica or zinc-deficiency dermatitis is the most common diagnosis than many practitioners realize with up to 10% of the patients in developed nations with the risk of zinc deficiency. The condition can be difficult to diagnose due to many similarly-presenting conditions. Read More

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http://dx.doi.org/10.7759/cureus.1667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5677339PMC
September 2017
16 Reads

Symmetrical inflammatory erosive plaques and blisters in an infant.

J Dtsch Dermatol Ges 2017 Sep 3;15(9):956-959. Epub 2017 Aug 3.

Department of Dermatology, Venereology, and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1111/ddg.12985DOI Listing
September 2017
18 Reads

Diagnosis of acrodermatitis enteropathica in resource limited settings.

BMJ Case Rep 2017 Aug 2;2017. Epub 2017 Aug 2.

Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.

Acrodermatitis enteropathica (AE) is a rare inherited zinc deficiency that usually manifests in infancy within days in cases of bottlefed infants and days to weeks after weaning in breastfed infants. It is characterised by diarrhoea, dermatitis, alopecia and systemic symptoms. We report a case of acquired nutritional AE in a 6-month-old female infant who had diarrhoeal episodes and the characteristic dermatitis lesions in the acral and anogenital regions. Read More

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http://dx.doi.org/10.1136/bcr-2017-220928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623307PMC
August 2017
5 Reads

Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC.

Biometals 2017 Oct 17;30(5):643-661. Epub 2017 Jul 17.

WG Cellular Neurobiology and Neuro-Nanotechnology, Department of Biological Sciences, University of Limerick, Limerick, Ireland.

Zn is essential for growth and development. The bioavailability of Zn is affected by several factors such as other food components. It is therefore of interest, to understand uptake mechanisms of Zn delivering compounds to identify ways to bypass the inhibitory effects of these factors. Read More

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http://link.springer.com/10.1007/s10534-017-0033-y
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http://dx.doi.org/10.1007/s10534-017-0033-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646115PMC
October 2017
39 Reads

Necrolytic Acral Erythema in Seronegative Hepatitis C.

Case Rep Dermatol 2017 Jan-Apr;9(1):69-73. Epub 2017 Mar 17.

Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Necrolytic acral erythema (NAE) is a distinctive skin disorder. The exact cause and pathogenesis is still unclear. Most studies report an association of NAE with hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.1159/000458406DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5465673PMC
March 2017
27 Reads