J Cutan Pathol 2018 Jan 2. Epub 2018 Jan 2.
Departments of Dermatology and Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Lyme disease classically evolves through clinical manifestations according to the stage of illness. Because many of the systemic symptoms are non-specific, and because serology may yield false negative results, cutaneous findings merit even greater importance to diagnosis. The prototypical skin lesion, erythema migrans (EM), occurs early and is the only independent diagnostic clinical feature according to the guidelines of the Infectious Diseases Society of America. Read More