330,005 results match your criteria Acquired Digital Fibrokeratoma


Thyroid Sequelae of Pediatric Cancer Therapy.

Horm Res Paediatr 2018 Dec 12:1-14. Epub 2018 Dec 12.

The hypothalamic-pituitary-thyroid axis is a common site of unintended, acquired disease either during or after the treatment of cancer. Children treated with external radiation therapy are at the highest risk for developing a thyroid-related late effect, but thyroid dysfunction and second primary thyroid neoplasms can also occur after treatment with radiopharmaceutical agents such as 131I-metaiodobenzylguanidine. Increasingly recognized is the development of early thyroid dysfunction as an off-target consequence of the more novel cancer therapeutics such as the tyrosine kinase inhibitors and immune checkpoint inhibitors. Read More

View Article
December 2018
1 Read

Development and evaluation of an arterial spin-labeling digital reference object for quality control and comparison of data analysis applications.

Phys Med Biol 2018 Dec 12. Epub 2018 Dec 12.

University of Wisconsin-Madison Department of Medical Physics, Madison, Wisconsin, UNITED STATES.

Longitudinal assessment of quantitative imaging biomarkers (QIBs) requires a comprehensive quality control (QC) program to minimize bias and variance in measurement results. In addition, the availability of data analysis software from multiple vendors emphasizes the need for a means of quantitatively comparing the computed QIB measures produced by the applications. The purpose of this work is to describe a digital reference object (DRO) that has been developed for the evaluation of arterial spin-labeling (ASL) measurement results. Read More

View Article
December 2018

Novel therapeutic approaches in primary hyperoxaluria.

Expert Opin Emerg Drugs 2018 Dec 12:1-9. Epub 2018 Dec 12.

a Division of Pediatric Nephrology , University Childrens Hospital, Universitatsklinikum Bonn , Bonn , Germany.

Introduction: Currently, three types of primary hyperoxaluria (PH I-III) are known, all based on different gene-mutations affecting the glyoxylate metabolism in the liver. Disease hallmark is an increased endogenous oxalate production and thus massively elevated urinary excretion of oxalate and other type-specific metabolites. Hyperoxaluria induces the formation of calcium-oxalate kidney stones and/or nephrocalcinosis. Read More

View Article
December 2018

Exploring the Role of Regional Anesthesia in the Treatment of the Burn Injured Patient: A Narrative Review of Current Literature.

Clin J Pain 2018 Dec 11. Epub 2018 Dec 11.

The University of Queensland, School of Nursing, Midwifery and Social Work, St Lucia, QLD, Australia, 4072.

Objectives: The review article was designed to assess the effectiveness of regional anesthesia, specifically peripheral nerve blocks, in the treatment of burn pain; with noting of clinical indications and contraindications for peripheral nerve block application, along with discussion of evidence-based analgesic strategies for providing improved, comprehensive burn pain management.

Methods: A search of relevant literature was performed using CINAHL, PubMed, EMBASE, Web of Science and SCOPUS with a publication date between January 2005 and December 2017.

Results: The search yielded ten results that met criteria. Read More

View Article
December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

View Article
December 2018

Physiotherapy practice patterns in gait rehabilitation for adults with acquired brain injury.

Brain Inj 2018 Dec 12:1-16. Epub 2018 Dec 12.

a Department of Physical Therapy , University of Toronto , Toronto , Canada.

Objective: Gait dysfunction is common following acquired brain injury (ABI). Clinical practice guidelines can improve patient outcomes; however, information regarding ABI-specific management of gait dysfunction is limited. This study aimed to describe practice patterns of Canadian physiotherapists regarding gait rehabilitation in adults post-ABI. Read More

View Article
December 2018

Evolving and Expanding the Roles of Mitophagy as a Homeostatic and Pathogenic Process.

Physiol Rev 2019 Jan;99(1):853-892

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego , La Jolla, California ; and Washington University School of Medicine, St. Louis, Missouri.

The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight control over the quality and quantity of these ubiquitous endosymbiotic organelles. Mitophagy, the targeted engulfment and destruction of mitochondria by the cellular autophagy apparatus, has conventionally been considered as the mechanism primarily responsible for mitochondrial quality control. However, our understanding of how, why, and under what specific conditions mitophagy is activated has grown tremendously over the past decade. Read More

View Article
January 2019

A Novel Near-infrared Hyperspectral Absorption/Scattering Imaging Method using Multiple Ground Plates for Evaluating Polymer Composites.

Anal Chem 2018 Dec 12. Epub 2018 Dec 12.

This paper proposes a nondestructive method of evaluating polymer composites using near-infrared (NIR) diffuse reflection spectroscopy with multiple ground plates. Wavelength-dependent absorption and reduced scattering coefficients were acquired to evaluate the chemical structure and the concentration of the substances from absorption and to determine the size and the dispersity of filler in the polymer domain from scattering. NIR spectra of the sample were measured on multiple ground plates, namely, "ground-plate-dependent" diffuse reflection spectra. Read More

View Article
December 2018

Neurobehavioural mechanisms of threat generalization moderate the link between childhood maltreatment and psychopathology in emerging adulthood

J Psychiatry Neurosci 2018 12 12;44(1):1-10. Epub 2018 Dec 12.

From the Department of Psychiatry and Psychology, School of Mental Health and Neuroscience, EURON, Maastricht University, Maastricht, The Netherlands (Lange, Goossens, Bakker, Michielse, Leibold, Marcelis, van Os, van Amelsvoort, Schruers); Department of Neuroscience, Center for Contextual Psychiatry, Center for Clinical Psychiatry, KU Leuven, Leuven, Belgium (van Winkel); Department of Psychology, University of Minnesota, Minneapolis, MN, USA (Lissek); Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, The Netherlands (Marcelis); Department of Psychiatry, Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, The Netherlands (Wichers); Department of Psychosis Studies, Institute of Psychiatry, King’s College London, King’s Health Partners, London, UK (van Os); Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands (van Os); Faculty of Psychology, Center for Experimental and Learning Psychology, KU Leuven, Leuven, Belgium Schruers).

Background: Childhood maltreatment is a transdiagnostic risk factor for later psychopathology and has been associated with altered brain circuitry involved in the processing of threat and safety. Examining threat generalization mechanisms in young adults with childhood maltreatment and psychiatric symptoms may elucidate a pathway linking early-life adversities to the presence of subclinical psychopathology.

Methods: We recruited youth aged 16–25 years with subclinical psychiatric symptomatology and healthy controls. Read More

View Article
December 2018

[Contributions of master in international health & nutrition policies alumni to African development.]

Sante Publique 2018 July August;30(4):535-544

Objectives: This study aims to analyze how graduates, coming from low income Francophone countries, of the Master in International Health and Nutrition Policies program at the Senghor University are a new human capital bringing an original contribution to the global development of African communities.

Methods: A secondary analysis of qualitative findings responded to the research question about the evidences of the impact of this new human capital over the community development of countries where the graduates worked. Findings also revealed graduates' potential to contribute to future endeavors in global health. Read More

View Article
December 2018

Proteomic analysis of the acquired enamel pellicle formed on human and bovine tooth: a study using the Bauru in situ pellicle model (BISPM).

J Appl Oral Sci 2018 Dec 10;27:e20180113. Epub 2018 Dec 10.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departmento de Ciências Biológicas, Bauru, SP, Brasil.

Objectives: The acquired enamel pellicle (AEP) is an organic film, bacteria-free, formed in vivo as a result of the selective adsorption of salivary proteins and glycoproteins to the solid surfaces exposed to the oral environment. Objective: This study aimed to compare the proteomic profile of AEP formed in situ on human and bovine enamel using a new intraoral device (Bauru in situ pellicle model - BISPM).

Material And Methods: Material and Methods: One hundred and eight samples of human and bovine enamel were prepared (4×4 mm). Read More

View Article
December 2018

Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

UT Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objective: Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.

Methods: In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Read More

View Article
December 2018

Topography of 11C-Pittsburgh compound B uptake in Alzheimer's disease: a voxel-based investigation of cortical and white matter regions.

Braz J Psychiatr 2018 Dec 6. Epub 2018 Dec 6.

Núcleo de Apoio à Pesquisa em Neurociência Aplicada (NAPNA), USP, São Paulo, SP, Brazil.

Objective: To compare results of positron emission tomography (PET) with carbon-11-labeled Pittsburgh compound B (11C-PIB) obtained with cerebellar or global brain uptake for voxel intensity normalization, describe the cortical sites with highest tracer uptake in subjects with mild Alzheimer's disease (AD), and explore possible group differences in 11C-PIB binding to white matter.

Methods: 11C-PIB PET scans were acquired from subjects with AD (n=17) and healthy elderly controls (n=19). Voxel-based analysis was performed with statistical parametric mapping (SPM). Read More

View Article
December 2018

[Purchase of products directly from family farms for the National School Feeding Program (PNAE): cross-sectional study with the universe of brazilian municipalities].

Cien Saude Colet 2018 Dec;23(12):4153-4164

Centro Colaborador em Alimentação e Nutrição do Escolar do Estado de Santa Catarina, Universidade Federal de Santa Catarina. Campus Universitário, Centro de Ciências da Saúde, Departamento de Nutrição Sala 215, Trindade. 88040-900 Florianópolis SC Brasil.

The integration of family farming with school meals has the potential to improve the variety of school menus thereby bringing the production and consumption of food into closer alignment. This study researched the Brazilian municipalities with respect to the purchase of food from family farms for the National School Food Program. It involved a cross-sectional study conducted via an electronic questionnaire sent to 5,565 municipalities in the country. Read More

View Article
December 2018

CAN VIRTUAL REALITY BE AS GOOD AS OPERATING ROOM TRAINING? EXPERIENCE FROM A RESIDENCY PROGRAM IN GENERAL SURGERY.

Arq Bras Cir Dig 2018 Dec 6;31(4):e1397. Epub 2018 Dec 6.

Department of Surgery, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background: The increasingly intense usage of technology applied to videosurgery and the advent of robotic platforms accelerated the use of virtual models in training surgical skills.

Aim: To evaluate the performance of a general surgery department's residents in a video-simulated laparoscopic cholecystectomy in order to understand whether training with virtual reality is sufficient to provide the skills that are normally acquired in hands-on experience at the operating room.

Methods: An observational study with twenty-five first- and second-year general surgery residents. Read More

View Article
December 2018
1 Read

Identification of differentiated functional modules in papillary thyroid carcinoma by analyzing differential networks.

J Cancer Res Ther 2018 Dec;14(Supplement):S969-S974

Department of Ultrasound, Linzi District People's Hospital, Zibo 255 400, Shandong Province, China.

Purpose: The incidence of papillary thyroid carcinoma (PTC) has dramatically increased over the past two decades. This study aimed to investigate the disparity of gene expression between PTC and normal tissues.

Materials And Methods: Gene chip data of E-GEOD-33630 and E-GEOD-60542 were acquired and downloaded from European Bioinformatics Institute Part of the European Molecular Biology Laboratory website. Read More

View Article
December 2018

The metabolic signature of Primary Biliary Cholangitis and its comparison with Coeliac Disease.

J Proteome Res 2018 Dec 12. Epub 2018 Dec 12.

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease characterized by ongoing inflammatory destruction of the interlobular bile ducts, eventually leading to chronic cholestasis and biliary cirrhosis. This study primarily aims to define the metabolomic signature of PBC after comparison with healthy controls (HC). Secondly it aims at evaluating the possible metabolic association between PBC and coeliac disease (CD), an immune-mediated disorder frequently associated with PBC. Read More

View Article
December 2018
1 Read

Analysis of C3 Nephritic Factors by ELISA.

Authors:
Lillemor Skattum

Methods Mol Biol 2019 ;1901:177-182

Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, Lund, Sweden.

Autoantibodies to the C3 convertase of the alternative pathway of complement, called C3 nephritic factors (C3NeF), cause persistently low C3 in the circulation and production of C3 degradation fragments due to prolonged stabilization of the C3 convertase. C3NeF are associated with glomerulopathy, acquired partial lipodystrophy, and less frequently with increased susceptibility to meningococcal infection. Analysis of C3NeF is an important part of the diagnostic workup of C3 glomerulopathy, but their identification is difficult presumably due to considerable heterogeneity. Read More

View Article
January 2019

Liquid-Biopsy-Based Identification of EGFR T790M Mutation-Mediated Resistance to Afatinib Treatment in Patients with Advanced EGFR Mutation-Positive NSCLC, and Subsequent Response to Osimertinib.

Target Oncol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, 1090, Vienna, Austria.

Background: Acquired epidermal growth factor receptor (EGFR) T790M mutation is the primary resistance mechanism to first-generation EGFR tyrosine kinase inhibitors (TKIs) used in advanced, EGFR mutation-positive non-small-cell lung cancer (NSCLC). Available data, predominantly in Asian patients, suggest that this mutation is also the major cause of resistance to the irreversible ErbB family blocker, afatinib. For EGFR T790M-positive patients who progress on EGFR TKI therapy, osimertinib is an effective treatment option. Read More

View Article
December 2018

Colorimetric determination of glucose in solution and via the use of a paper strip by exploiting the peroxidase and oxidase mimicking activity of bimetallic Cu-Pd nanoparticles deposited on reduced graphene oxide, graphitic carbon nitride, or MoS nanosheets.

Mikrochim Acta 2018 Dec 11;186(1):13. Epub 2018 Dec 11.

Advanced Materials Group, Materials Sciences and Technology Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785006, India.

This work describes the preparation of bimetallic Cu-Pd nanoparticles (NPs) on supports like reduced graphene oxide (rGO), graphitic carbon nitride (g-CN) and MoS sheets with a size of <10 nm. rGO is found to be the best support for synthesizing Cu-Pd NPs with controlled shape, size and oxidation state. The Cu-Pd/rGO nanocomposite also demonstrated the best peroxidase and oxidase mimicking activity compared to Cu-Pd/g-CN and Cu-Pd/MoS nanocomposites. Read More

View Article
December 2018
1 Read

Delafloxacin meglumine for the treatment of acute bacterial skin and skin structure infections (ABSSSI).

Drugs Today (Barc) 2018 Nov;54(11):657-666

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, India.

Delafloxacin meglumine (Baxdela, WQ-3034, ABT-492, RX-3341; Melinta Therapeutics) was approved by the U.S. Food and Drug Administration (FDA) in June 2017 for the treatment of acute bacterial skin and skin structure infections on the basis of data from two phase III trials. Read More

View Article
November 2018
1 Read

Virus titre determines the efficiency of (Aphididae: Hemiptera) to transmit banana bunchy top virus.

Virusdisease 2018 Dec 26;29(4):499-505. Epub 2018 Sep 26.

Molecular Virology Lab, Division of Crop Protection, Department of Molecular Virology, ICAR-National Research Centre for Banana, Thogamalai Road, Thayanur Post, Tiruchchirappalli, Tamil Nadu 620102 India.

Banana bunchy top disease (BBTD) caused by banana bunchy top virus (BBTV) is one of the most serious viral diseases of banana and plantains. BBTV is transmitted by (Hemiptera, Aphididae) in a persistent circulative manner. Better knowledge of vector-virus-host relationship and the mechanism of transmission is essential for developing an effective control strategy. Read More

View Article
December 2018

Structural Basis for the Limited Response to Oxidative and Thiol-Conjugating Agents by Triosephosphate Isomerase From the Photosynthetic Bacteria .

Front Mol Biosci 2018 27;5:103. Epub 2018 Nov 27.

Laboratorio Nacional de Genómica para la Biodiversidad, Centro de Investigación y de Estudios Avanzados del IPN, Guanajuato, Mexico.

In plants, the ancestral cyanobacterial triosephosphate isomerase (TPI) was replaced by a duplicated version of the cytosolic TPI. This isoform acquired a transit peptide for chloroplast localization and functions in the Calvin-Benson cycle. To gain insight into the reasons for this gene replacement in plants, we characterized the TPI from the photosynthetic bacteria (SyTPI). Read More

View Article
November 2018

Rett Syndrome in Males: A Case Report and Review of Literature.

Cureus 2018 Oct 4;10(10):e3414. Epub 2018 Oct 4.

Neurology, University of Missouri, Columbia, USA.

Rett syndrome (RTT) is a neurodevelopmental disorder in which a period of normal development is followed by regression of previously acquired skills. RTT was originally thought to be present exclusively in females. However, advances in genetic testing and phenotypic identification revealed that it is not a female-only disorder as cases of males with similar phenotype were reported. Read More

View Article
October 2018

Spatial shifts in frame-based Gamma Knife radiosurgery: A case for cone beam CT imaging as quality assurance using the Gamma Knife® Icon™.

J Radiosurg SBRT 2018 ;5(4):315-322

Department of Neurological Surgery, University of Virginia Medical Center, PO Box 800212, Charlottesville, VA 22908-0212, USA.

Background: Cone beam CT (CBCT) imaging has been integrated into the most recent version of the Leksell Gamma Knife for the primary purpose to facilitate fractionated therapy.

Case Description: This case study presents three patients where the CBCT system of the Gamma Knife Icon discovered potentially clinically significant frame shifts. In each case, patients were imaged with volumetric MR prior to stereotactic frame placement. Read More

View Article
January 2018

Selective and super-selective C-arm based cone beam CT angiography (CBCTA) with DynaCT for CyberKnife radiosurgery planning of intracranial arteriovenous malformations (AVMs).

J Radiosurg SBRT 2018 ;5(4):305-313

Division of Radiation Oncology, University of Ottawa, Ottawa, ON, Canada.

Background: Successful radiosurgery for intracranial arteriovenous malformations (AVMs) requires accurate delineation of the nidus in 3D. Exact targeting and precise equipment is needed to achieve obliteration of the nidus while minimizing toxicity to the surrounding brain. In some micro-AVMs and poorly visible AVMs we have used cone beam CT angiography (CBCTA) with selective and super-selective angiography where a micro-catheter is advanced into the feeding arteries- to assist with nidus definition for CyberKnife radiosurgery planning. Read More

View Article
January 2018

Management of Acquired Hemophilia A in Elderly Patients.

Case Rep Hematol 2018 13;2018:6757345. Epub 2018 Nov 13.

Division of Hematology, Takasago-Seibu Hospital, Takasago 676-0812, Japan.

This report describes six elderly patients with acquired hemophilia A (AHA), including four individuals aged ≥90 years. Bleeding symptoms were subcutaneous or intramuscular hemorrhage (=4), hematuria (=1), and hemorrhagic shock after tooth extraction (=1). Factor VIII (FVIII) activity ranged from <1. Read More

View Article
November 2018

Determinants of sporadic infections in Denmark: a nationwide case-control study among children and young adults.

Clin Epidemiol 2018 21;10:1695-1707. Epub 2018 Nov 21.

Infectious Disease Epidemiology & Prevention, Statens Serum Institut, Copenhagen, Denmark,

Background: Each year more than 4,000 cases of campylobacteriosis are reported in Denmark, making it the most common bacterial gastrointestinal infection. Here we describe a case-control study to identify sources of infection with a focus on environmental factors.

Methods: From January to December 2016, we conducted a prospective case-control study among Danish persons aged 1-30 years. Read More

View Article
November 2018

Quaternized chitosan promotes the antiproliferative effect of vemurafenib in melanoma cells by increasing cell permeability.

Authors:
Min Li Ying Yang

Onco Targets Ther 2018 22;11:8293-8299. Epub 2018 Nov 22.

Department of Plastic Surgery, Xiangya Hospital, Central South University, Changsha 410008, PR China,

Background: As one of the most invasive cutaneous carcinomas among all types of skin cancer, malignant melanoma remains a severe challenge in oncology and plastic surgery. Selective small-molecule inhibitors of V600E-mutant B-Raf (vemurafenib, for instance) have demonstrated satisfactory therapeutic efficacy in melanoma patients. However, acquired resistance during the period of drug administration has limited their clinical application. Read More

View Article
November 2018
1 Read

P-Glycoprotein Expression in Indian Breast Cancer Patients with Reference to Molecular Subtypes and Response to Anthracycline-Based Chemotherapy-a Prospective Clinical Study from a Developing Country.

Indian J Surg Oncol 2018 Dec 31;9(4):524-529. Epub 2018 Jul 31.

4King George's Medical University, Lucknow, UP India.

Chemo-resistance is an important factor determining the response of tumor to neoadjuvant chemotherapy (NACT). Our study was aimed to determine the role of P-glycoprotein (P-glyp) expression as a predictor of response to NACT in locally advanced breast cancer (LABC) patients with special reference to molecular subtypes. Sixty cases of locally advanced breast cancer (LABC) were subjected to trucut biopsy and the tissue samples were evaluated immunohistochemically for P-glyp, ER, PR, and Her 2 neu status. Read More

View Article
December 2018

infection in chronic kidney disease patients undergoing hemodialysis in Egypt.

J Parasit Dis 2018 Dec 19;42(4):630-635. Epub 2018 Oct 19.

4Department of Zoology, Faculty of Science, Damanhour University, Damanhûr, 21634 Egypt.

Patients with chronic renal failure are more susceptible to infections due to acquired immunodeficiency caused by uremia. Parasitic infections are one of the significant causes of morbidity and mortality in those patients, So we aimed to assess the prevalence of spp. and other protozoan infections in patients undergoing hemodialysis in Qena Governorate, Upper Egypt. Read More

View Article
December 2018

HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases.

Oncogene 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Molecular Biology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, via La Masa 19, 20157, Milano, Italy.

Targeting of histone methylation has therapeutic potential in oncology. Here, we provide proof-of-principle that pharmacological inhibition of KDM5 histone-demethylases is a new strategy for the personalized treatment of HER2 breast cancer. The anti-proliferative effects of the prototype of a new class of selective KDM5-inhibitors (KDM5-inh1) are evaluated in 40 cell lines, recapitulating the heterogeneity of breast cancer. Read More

View Article
December 2018

Transcription factor DUO1 generated by neo-functionalization is associated with evolution of sperm differentiation in plants.

Nat Commun 2018 12 11;9(1):5283. Epub 2018 Dec 11.

Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.

Evolutionary mechanisms underlying innovation of cell types have remained largely unclear. In multicellular eukaryotes, the evolutionary molecular origin of sperm differentiation is unknown in most lineages. Here, we report that in algal ancestors of land plants, changes in the DNA-binding domain of the ancestor of the MYB transcription factor DUO1 enabled the recognition of a new cis-regulatory element. Read More

View Article
December 2018

Acquisition and Loss of CTX-M-Producing and Non-Producing Escherichia coli in the Fecal Microbiome of Travelers to South Asia.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Institute of Microbiology and Infection, University of Birmingham, Birmingham, United Kingdom.

Over 80% of travelers from the United Kingdom to the Indian subcontinent acquire CTX-M-producing (CTX-M-EC), but the mechanism of CTX-M-EC acquisition is poorly understood. We aimed to investigate the dynamics of CTX-M-EC acquisition in healthy travelers and how this relates to populations of non-CTX-M-EC in the fecal microbiome. This is a prospective observational study of healthy volunteers traveling from the United Kingdom to South Asia. Read More

View Article
December 2018

Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

School of Chemistry and Molecular Biosciences and Australian Infectious Diseases Research Centre, The University of Queensland, Brisbane, QLD, Australia

The World Health Organization reports that antibiotic-resistant pathogens represent an imminent global health disaster for the 21st century. Gram-positive superbugs threaten to breach last-line antibiotic treatment, and the pharmaceutical industry antibiotic development pipeline is waning. Here we report the synergy between ionophore-induced physiological stress in Gram-positive bacteria and antibiotic treatment. Read More

View Article
December 2018

Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in Pseudomonas aeruginosa.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. Read More

View Article
December 2018

The Protozoan Targets Bacteria with Laterally Acquired NlpC/P60 Peptidoglycan Hydrolases.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

School of Biological Sciences, University of Auckland, Auckland, New Zealand

The human eukaryotic pathogen causes trichomoniasis, a prevalent sexually transmitted infection. This extracellular protozoan is intimately associated with the human vaginal mucosa and microbiota, but key aspects of the complex interactions between the parasite and the vaginal bacteria remain elusive. We report that has acquired, by lateral gene transfer from bacteria, genes encoding peptidoglycan hydrolases of the NlpC/P60 family. Read More

View Article
December 2018

Tailoring Empirical Antimicrobial Therapy in Subjects With Ventilator-Associated Pneumonia With a 10-Hour E-Test Approach.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

Univ. de Bordeaux, UMR 5234 CNRS 'Microbiologie Cellulaire et Moléculaire et Pathogénicité'', Bordeaux, France.

Background: In a previous study of subjects suspected of having ventilator-associated pneumonia, a rapid susceptibility testing approach by using ETEST (BioMérieux) strips directly applied to bronchoalveolar lavage samples provided valuable information at hour 24. The primary objective of this study was to assess a new direct specimen testing by using an even more-rapid E-test approach (at hour 10), which could promote an early de-escalation of the antimicrobial therapy.

Methods: Twenty-eight subjects with ventilator-associated pneumonia admitted to a medical ICU were prospectively included. Read More

View Article
December 2018

Use of Novel Combination Therapies in the Treatment of Advanced HR+/HER2- Breast Cancer.

Authors:

J Natl Compr Canc Netw 2018 Dec;16(suppl 1):S5-S17

Endocrine therapy remains the backbone for treatment of hormone receptor-positive breast cancer in the metastatic setting. Despite the effectiveness of endocrine therapy, primary and acquired endocrine resistance continue to be important clinical challenges. The landscape of metastatic breast cancer treatment has changed considerably with the incorporation of novel agents, including cyclin-dependent kinase 4/6 and mammalian target of rapamycin inhibitors. Read More

View Article
December 2018

Attentional selectivity, automaticity, and self-efficacy predict simulator-acquired skill transfer to the clinical environment.

Am J Surg 2018 Nov 27. Epub 2018 Nov 27.

Department of Surgery, Indiana University School of Medicine, USA. Electronic address:

Introduction: Several studies demonstrated that simulator-acquired skill transfer to the operating room is incomplete. Our objective was to identify trainee characteristics that predict the transfer of simulator-acquired skill to the operating room.

Methods: Trainees completed baseline assessments including intracorporeal suturing (IS) performance, attentional selectivity, self-reported use of mental skills, and self-reported prior clinical and simulated laparoscopic experience and confidence. Read More

View Article
November 2018

ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.

J Orthop Surg Res 2018 Dec 11;13(1):316. Epub 2018 Dec 11.

Department of Orthopaedic and Traumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. Read More

View Article
December 2018

The impact of the tumor shrinkage by initial EGFR inhibitors according to the detection of EGFR-T790M mutation in patients with non-small cell lung cancer harboring EGFR mutations.

BMC Cancer 2018 Dec 11;18(1):1241. Epub 2018 Dec 11.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto, 602-8566, Japan.

Background: The EGFR-T790M mutation is clinically detected using re-biopsy in approximately 50% of patients with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in advanced non-small cell lung cancer (NSCLC) who harbor EGFR mutations. However, little is known about the population of NSCLC patients who develop acquired resistance due to the T790M mutation. In this study, we focused on the emergence of the T790M mutation and analyzed patients refractory to initial EGFR-TKIs with successful re-biopsy samples. Read More

View Article
December 2018
1 Read

Bloodstream infections during post-cardiotomy extracorporeal membrane oxygenation: Incidence, risk factors, and outcomes.

Int J Artif Organs 2018 Dec 11:391398818817325. Epub 2018 Dec 11.

2 ECMO Team, IRCCS Policlinico San Donato, Milan, Italy.

Introduction:: Veno-arterial extracorporeal membrane oxygenation after heart surgery is a relatively common procedure. It is easily applicable but associated with a number of complications, including bloodstream infections. The aim of this study is to determine the current rate and the risk factors related to bloodstream infections acquired during post-cardiotomy veno-arterial extracorporeal membrane oxygenation. Read More

View Article
December 2018

Goal-setting in geriatric rehabilitation: a systematic review and meta-analysis.

Clin Rehabil 2018 Dec 12:269215518818224. Epub 2018 Dec 12.

Department of General Practice & Elderly Care Medicine and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, The Netherlands.

Objective:: To explore the effect of goal-setting on physical functioning, quality of life and duration of rehabilitation in geriatric rehabilitation compared to care as usual.

Data Sources:: Medline, Embase, CINAHL, PsycINFO and the Cochrane Library were searched from initiation to October 2018.

Methods:: We included randomized controlled trials (RCTs), controlled before-after studies and studies using historic controls of older patients (mean age ⩾55 years) receiving rehabilitation for acquired disabilities. Read More

View Article
December 2018

Z-Scheme Photocatalytic CO2 Reduction on a Heterostructure of Oxygen-Defective ZnO/Reduced Graphene Oxide/UiO-66-NH2 under Visible Light.

ACS Appl Mater Interfaces 2018 Dec 12. Epub 2018 Dec 12.

The construction of a Z-scheme heterojunction is an effictive way to isolate photogenerated electron-holes and enhance the activity of the semiconductor photocatalysts. However, the Z-scheme heterojunctions based on metal organic framework (MOF) were rarely reported. Herein, a novel oxygen-defective ZnO (O-ZnO)/reduced graphene oxide (rGO)/UiO-66-NH2 Z-scheme heterojunction has been prepared by a facile solvothermal route. Read More

View Article
December 2018

Multiple coronary fistula formation associated with a huge left atrial thrombus in rheumatic mitral valve stenosis.

J Cardiol Cases 2014 Mar 3;9(3):124-126. Epub 2014 Jan 3.

Atherosclerosis Prevention Research Center, Imam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Acquired fistulous communication with the left atrial (LA) chamber has been described in the presence of LA mural thrombus in patients with rheumatic mitral stenosis (MS). Hereby, we present the case of a 74-year-old man with rheumatic MS and a huge LA thrombus found in echocardiography. Coronary angiography revealed an extensive fistula formation feeding mainly from the atrial branches of left circumflex and right coronary arteries and draining into the LA chamber. Read More

View Article

Acquired QT interval prolongation and ventricular arythmias associated with brucellosis: A case report and review of literature.

J Cardiol Cases 2011 Oct 23;4(2):e121-e125. Epub 2011 Jul 23.

Akdeniz University, School of Medicine Cardiology Department, Dumlupinar Street, Antalya, Turkey.

Brucellosis is a zoonosis caused by species and usually involves the lymphoreticular system. Cardiovascular involvement is rare but fatal. Endocarditis is the most common cardiovascular manifestation of brucellosis. Read More

View Article
October 2011

Intravascular ultrasound and histopathological observations in a patient with very late sirolimus-eluting stent thrombosis.

J Cardiol Cases 2012 Nov 15;6(5):e126-e129. Epub 2012 May 15.

Department of Cardiovascular Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.

This case report describes an autopsy case of very late stent thrombosis, which was associated with intravascular ultrasound findings of late-acquired stent malapposition with thrombotic materials and marked positive vascular remodeling at the site of the sirolimus-eluting stent implantation. Histopathological examination showed both destructive and proliferative reactions had occurred in the same stented coronary arterial wall 44 months after sirolimus-eluting stent implantation. Long-lasting severe local inflammation beyond healing reaction, causing vessel enlargement, may be related to very late stent thrombosis. Read More

View Article
November 2012

Recurrence of late incomplete stent apposition after very late stent thrombosis following drug-eluting stent implantation.

J Cardiol Cases 2012 Oct 21;6(4):e116-e117. Epub 2012 Jul 21.

Department of Cardiology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan.

A 48-year old man was admitted to our hospital because of chest pain 20 months after sirolimus-eluting stent implantation to his left anterior descending coronary artery. A coronary angiogram showed a thrombosis of the stented segment, which was successfully treated with bare-metal stent implantation. One month later, optical coherence tomography (OCT) demonstrated late-acquired incomplete stent apposition (ISA) in the stented segment. Read More

View Article
October 2012

Acquired long QT syndrome and ventricular tachycardia in a patient on flecainide therapy.

J Cardiol Cases 2011 Jun 29;3(3):e137-e142. Epub 2011 Mar 29.

Division of Cardiology, Department of Internal Medicine, Yeungnam University Hospital, 317-1 Daemyoung Dong, Nam-Gu, Daegu 705-717, South Korea.

This case report describes a 54-year-old man presenting with loss of consciousness due to acquired long QT syndrome shortly after flecainide therapy. The patient had no common risk factors for acquired long QT syndrome. Prior to onset of ventricular tachycardia, bradyarrhythmia and short-long-short sequence were observed with a prolonged QT interval of 710 ms. Read More

View Article