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J Am Podiatr Med Assoc 2021 Dec 15;111(6). Epub 2021 Dec 15.

Acquired digital fibrokeratoma is a rare and benign fibrous tumor; it is usually asymptomatic, and frequently arises from the fingers. The diagnosis is easily confirmed by pathologic evaluation. However, in some cases, it may be misdiagnosed as other benign conditions, mainly adnexal tumors and common warts, especially when located on the foot and toes. Read More

Indian J Dermatol Venereol Leprol 2022 Mar-Apr;88(2):275

Dermatology Unit, Department of Medical, Surgical and Neurosciences, University of Siena, Siena (Italy).

Dermatol Online J 2021 Nov 15;27(11). Epub 2021 Nov 15.

Northwestern University Feinberg School of Medicine, Chicago, IL.

Acquired digital fibrokeratoma is a benign fibrous tumor usually located on the toes and fingers. A 63-year-old man with an acquired giant plantar fibrokeratoma is described. He presented with an asymptomatic exophytic nodule of ten years duration; there is no history of trauma to the site. Read More

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):121-124

Department of Dermatology, Venereology, and Leprology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.

Acquired ungual fibrokeratomas are uncommon fibrous tissue tumors that are located in the ungual area. They usually presents as asymptomatic, solitary, smooth, dome-shaped, or fingerlike, flesh-colored papules accompanying nail deformities, including a longitudinal groove and trachyonychia. Acquired periungual fibrokeratoma is considered a topographical variant of acquired digital fibrokeratoma; it has a unique "garlic clove" shape. Read More

J Cutan Aesthet Surg 2020 Jul-Sep;13(3):261-263

Department of Burns and Plastic Surgery, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.

Acquired digital fibrokeratoma is an uncommon, benign fibrous tumor that usually occurs in adults as a solitary lesion with a typical size of less than 1 cm. We present a case with periungual growth and nail plate deformity. The growth was completely excised after raising the epinychial flap and the fold was reconstructed. Read More

Dermatol Ther (Heidelb) 2020 Oct 29;10(5):949-966. Epub 2020 Jul 29.

Compass Dermatopathology, San Diego, CA, USA.

Cellular digital fibroma is a benign fibrous lesion that typically occurred on either a finger or a toe. Cellular digital fibroma was introduced as a distinctive cluster of differentiation 34 (CD34)-positive lesion in July 2005. Cellular digital fibroma has been described in 20 patients: 12 men and 8 women. Read More

Foot (Edinb) 2020 Sep 26;44:101681. Epub 2020 Mar 26.

Wake Forest Baptist Hospital, DPM, Dept of Orthopedic Surgery; 1 Medical Center Blvd, Winston-Salem, NC 27151, United States.

Acquired digital fibrokeratomas are a benign soft tissue tumor with typical appearance and anatomical locations. This lesion generally occurs in middle aged males with common sites of occurrence in the digits of upper or lower extremities. Previous case studies have reported incidences of this lesion appearing on heels of middle-aged males but are generally described as giant digital fibrokeratoma based on the lesion's diameter. Read More

Cutis 2019 Jun;103(6):340-342

Department of Dermatology, Weill Cornell Medicine, New York, New York, USA.

A 53-year-old woman presented with an asymptomatic nodule on the distal subungual right fifth fingernail that had slowly enlarged over the last year. An excisional biopsy showed an acanthotic epidermis surmounted by hyperkeratotic scale as well as a fibrotic dermis with collagen bundles assuming a vertical orientation to the long axis of the epidermis, characteristic of an acquired digital fibrokeratoma (ADF). There was no sign of recurrence 4 months following excision. Read More

J Clin Aesthet Dermatol 2019 May 1;12(5):17-18. Epub 2019 May 1.

Drs. Garg, Sondhu, Kaur, are with the Department of Dermatology and Venereology and Dr. Punia is with the Department of Pathology, all at the Government Medical College and Hospital in Chandigarh, India.

Skin Appendage Disord 2019 Feb 29;5(2):111-113. Epub 2018 Aug 29.

Clinic of Dermatology, Brugmann University Hospital, Brussels, Belgium.

Acquired digital fibrokeratoma (ADFK) is a benign tumor. Clinically, it usually presents as skin-colored, slow-growing firm fibrous projection with a characteristic hyperkeratotic collarette at its base. It has a predilection for the periungual tissue. Read More

Ned Tijdschr Geneeskd 2018 09 24;162. Epub 2018 Sep 24.

UMCG-Rijksuniversiteit Groningen, afd. Plastische chirurgie.

A 23-year-old woman had a painful, growing mass close to the nail of her left index finger. The differential diagnosis consisted of acquired digital fibrokeratoma, digital fibromyxoma, periungual fibroma or verruca vulgaris. Surgical excision of the mass was performed, and histopathological analysis revealed a subungual exostosis. Read More

Int J Dermatol 2019 Feb 19;58(2):151-158. Epub 2018 May 19.

Veterans Affairs Medical Center, Brooklyn, NY, USA.

Acquired digital fibrokeratoma (ADFK) is a rare, benign, fibrous tumor that most often occurs on fingers. It may resemble a rudimentary supernumerary digit and is often misdiagnosed as another common benign condition, such as common wart. It is typically asymptomatic and occurs as a solitary nodule less than 1 cm in diameter. Read More

J Dermatol 2018 Aug 27;45(8):e234-e235. Epub 2018 Feb 27.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Presse Med 2016 Jun 12;45(6 Pt 1):608-10. Epub 2016 May 12.

CHU Ibn Sina, université Mohammed V, faculté de médecine et de pharmacie, service de dermatologie et vénérologie, Rabat, Maroc.

Ann Dermatol Venereol 2016 May 23;143(5):407-8. Epub 2016 Apr 23.

Service de dermatologie, hôpital Saint-André, CHU de Bordeaux, 1, rue Jean-Burguet, 33076 Bordeaux cedex, France. Electronic address:

J Dermatol 2016 Jan 5;43(1):107-8. Epub 2015 Oct 5.

Department of Dermatology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Int J Dermatol 2015 Nov 30;54(11):1214-25. Epub 2015 Jul 30.

Veterans Affairs Hospital & SUNY Downstate, Brooklyn, NY, USA.

There is little discussion of tumors arising in the digits in the dermatology literature. The patient with an undifferentiated mass of the finger is frequently encountered in the clinic, and variances in presentation of common and uncommon entities pose a challenge that may prompt further investigation for proper diagnosis and treatment. In this review, the authors illustrate the approach and work-up of an unknown digit mass of a 45-year-old female patient. Read More

Presse Med 2015 Jul-Aug;44(7-8):843-5. Epub 2015 Jun 3.

CHU Ibn Sina, université Mohamed V, service de dermatologie et vénérologie, Rabat, Maroc.

J Cutan Pathol 2015 Sep 1;42(9):652-6. Epub 2015 Jun 1.

Department of Dermatology, Inselspital Bern University Hospital, Bern, Switzerland.

Acquired periungual fibrokeratomas are benign fibrous tissue tumors and are considered as the topographical variant of acquired digital fibrokeratoma. They usually present as solitary tumors. In some instance, the entity may appear in multibranched fashion. Read More

Int J Surg Case Rep 2015 25;10:187-90. Epub 2015 Mar 25.

FRCS, Consultant Orthopaedics Surgeon, Royal Derby Hospital, United Kingdom. Electronic address:

Introduction: Acquired digital fibrokeratoma is an uncommon, benign fibrous tumour that usually occurs in adults as a solitary lesion with a typical size of less than 1cm.

Case Presentation: A 48-year-old Afro-Caribbean man presented to our foot and ankle clinic with a long-standing growth over the plantar aspect of the distal phalanx of the left great toe. The growth was painful and affected the patient's mobility. Read More

J Foot Ankle Surg 2014 Jul-Aug;53(4):449-52. Epub 2013 Nov 20.

Chief Resident, Department of Foot and Ankle Surgery, Regions Hospital and HealthPartners Institute for Education and Research, St. Paul, MN. Electronic address:

Acral fibrokeratoma is a relatively rare, benign lesion that is typically found on the fingers and toes but can also be found on the palms and soles. Several case reports have been published of this rare lesion, with only a few investigators describing lesions of the feet. The techniques of using skin from a portion of the mass to close the defect left from mass excision have been poorly reported. Read More

Ann Plast Surg 2015 Mar;74(3):304-5

From the Department of Plastic Surgery, University of Virginia, Charlottesville, VA.

Acquired digital fibrokeratomas are benign, rare tumors that develop most commonly on the fingers. They can have an appearance of a rudimentary supernumerary digit or be misdiagnosed as a more common condition, such as verruca vulgaris. There are no case reports described in the plastic surgery literature. Read More

Australas J Dermatol 2012 Feb 12;53(1):47-8. Epub 2011 Jul 12.

Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy.

Ann Dermatol 2011 Feb 28;23(1):64-6. Epub 2011 Feb 28.

Department of Dermatology, Maryknoll Hospital, Busan, Korea.

Acquired digital fibrokeratoma is an uncommon, benign fibrous tumor which usually occurs in adults as a solitary lesion. The most frequent locations are fingers and toes and the size of the tumor is generally small, around 3~5 mm. An 18-year-old female presented with a solitary, skin-colored, round and protruded nodule of the left great toe. Read More

Dermatol Online J 2010 Oct 15;16(10). Epub 2010 Oct 15.

Division of Dermatopathology, Mount Sinai School of Medicine, New York, New York, USA.

Acquired digital fibrokeratoma is a rare benign fibroepithelial tumor that typically presents as a solitary asymptomatic nodule on the finger or toe. Middle-aged adults are most commonly affected. Here we discuss an unusual case of acquired digital fibrokeratoma presenting as a cluster of multiple nodules on the sole of a 15-year-old boy. Read More

Dermatol Online J 2009 Jan 15;15(1). Epub 2009 Jan 15.

Department of Dermatology, National Medical Center, Seoul, Korea.

A 35-year-old male presented with a slowly growing keratotic tumor on the plantar aspect of his left second toe. Over a ten-year period, the projecting tumor had grown to the size of 7 x 18 mm without causing any symptoms. Three months prior to presentation, a red and polypoid papule of 5 x 5 mm-size began to develop within the original tumor. Read More

Clin Exp Dermatol 2009 Mar;34(2):257-9

Indian J Dermatol Venereol Leprol 2009 Jan-Feb;75(1):72

Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry-605 006, India.

Dermatol Online J 2008 Dec 15;14(12):10. Epub 2008 Dec 15.

Universidade Federal Fluminense, Hospital Universitário Antônio Pedro - Serviço de Dermatologia. Niterói, Rio de Janeiro, Brasil.

Acquired digital fibrokeratomas (ADF) are benign and uncommon lesions consisting of collagenous papules and nodules covered by hyperkeratotic epidermis. These tumors occur mainly on the fingers and toes and infrequently on the palms and soles. They may possibly be triggered by a reaction to a trauma, ADF usually present as small and solitary dome-shaped lesions with a collarete of slightly raised skin at the base. Read More