329,948 results match your criteria Acquired Cystic Kidney Disease


B1+ phase retrieval for non-quadrature radio frequency excitation and its preliminary application in MR-EPT.

Phys Med Biol 2018 Dec 11. Epub 2018 Dec 11.

Department of Electrical & Electronics Engineering, Bilkent University, Bilkent, Ankara, ankara, TURKEY.

Non-quadrature radio frequency (RF) excitation has been widely studied in the fields of RF shimming, local SAR estimation, and MR-EPT with the use of multi-channel transceiver arrays. These studies generally require the retrieval of the complex transmit field B<sub>1</sub><sup>+</sup>, which can be accomplished by acquiring its magnitude and phase in different steps. Magnitude of the transmit field is acquired with the conventional methods which give accurate results for both quadrature and non-quadrature excitations. Read More

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December 2018

Piezoelectric barium titanate nanostimulators for the treatment of glioblastoma multiforme.

J Colloid Interface Sci 2018 Dec 4;538:449-461. Epub 2018 Dec 4.

Istituto Italiano di Tecnologia, Smart Bio-Interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Italy; Politecnico di Torino, Department of Mechanical and Aerospace Engineering, Corso Duca degli Abruzzi 24, 10129 Torino, Italy. Electronic address:

Major obstacles to the successful treatment of gliolastoma multiforme are mostly related to the acquired resistance to chemotherapy drugs and, after surgery, to the cancer recurrence in correspondence of residual microscopic foci. As innovative anticancer approach, low-intensity electric stimulation represents a physical treatment able to reduce multidrug resistance of cancer and to induce remarkable anti-proliferative effects by interfering with Ca and K homeostasis and by affecting the organization of the mitotic spindles. However, to preserve healthy cells, it is utterly important to direct the electric stimuli only to malignant cells. Read More

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December 2018

Evaluation of porcine circovirus type 2 infection in in vitro embryo production using naturally infected oocytes.

Theriogenology 2018 Dec 4;126:75-80. Epub 2018 Dec 4.

Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin, 150030, Heilongjiang, PR China. Electronic address:

In vitro fertilization (IVF) and somatic cell nuclear transfer (SCNT) are important breeding techniques for livestock. High-quality MII oocytes produced from in vitro maturation (IVM) are required for the two techniques listed above. The ovaries used for IVM operations are primarily acquired from commercial abattoirs, and the pathogen status of slaughtered animals becomes an unavoidable issue. Read More

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December 2018

Joint contractures and acquired deforming hypertonia in older people: Which determinants?

Ann Phys Rehabil Med 2018 Dec 8. Epub 2018 Dec 8.

Department of Medicine, Division of Physical Medicine and Rehabilitation, University of Ottawa, Bone and Joint Research Laboratory, The Ottawa Hospital Research Institute, ON, Canada.

Joint contractures and acquired deforming hypertonia are frequent in dependent older people. The consequences of these conditions can be significant for activities of daily living as well as comfort and quality of life. They can also negatively affect the burden of care and care costs. Read More

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December 2018

The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin.

Int J Biol Macromol 2018 Dec 8. Epub 2018 Dec 8.

Department of Internal Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China.

Acquired resistance to chemotherapy is a frequent challenge in cancer care and one of the leading causes for failing breast cancer therapies. There is accumulative clinical and experimental evidence indicating that microRNAs (miRNAs) play a crucial role in developing therapeutic resistance in cancer cells. We aimed to explore key miRNAs and associated mechanisms by which breast cancer develops chemoresistance. Read More

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December 2018

Measuring the Impact of Academic Cancer Network Development on Clinical Integration, Quality of Care, and Patient Satisfaction.

J Oncol Pract 2018 Dec;14(12):e823-e833

Yale New Haven Hospital; Yale School of Medicine; Yale Cancer Center; Smilow Cancer Hospital; and Community Health Educators Group, New Haven, CT.

Purpose:: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites.

Methods:: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network. Read More

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December 2018

Methicillin-resistant Staphylococcus aureus in urban Norway rat (Rattus norvegicus) populations: Epidemiology and the impacts of kill-trapping.

Zoonoses Public Health 2018 Dec 9. Epub 2018 Dec 9.

Canadian Wildlife Health Cooperative, Abbotsford, British Columbia, Canada.

Urban Norway rat (Rattus norvegicus) populations can carry the bacteria methicillin-resistant Staphylococcus aureus (MRSA). There are numerous knowledge gaps in the epidemiology of MRSA in these populations that limit understanding of its ecology in urban environments. For example, fecal shedding of MRSA, which may increase environmental contamination, has been reported in other species; however, it is unknown whether Norway rats carry the bacteria rectally. Read More

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December 2018

Trust, Money, and Power: Life Cycle Dynamics in Alliances Between Management Partners and Accountable Care Organizations.

Milbank Q 2018 Dec;96(4):755-781

Gillings School of Public Health, University of North Carolina at Chapel Hill.

Policy Points Accountable care organizations (ACOs) form alliances with management partners to access financial, technical, and managerial support. Alliances between ACOs and management partners are subject to destabilizing tension around decision-making authority, distribution of shared savings, and conflicting goals and values. Management partners may serve either as trainers, ultimately breaking off from the ACO, or as central drivers of the ACO. Read More

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December 2018

Brain glutamate, GABA, and glutamine levels and associations with recent drinking in treatment-naïve individuals with Alcohol Use Disorder versus light drinkers.

Alcohol Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychiatry and Behavioral Sciences.

Background: Proton Magnetic Resonance Spectroscopy ( H-MRS) studies have demonstrated abnormal levels of a variety of neurometabolites in inpatients/outpatients with Alcohol Use Disorder (AUD) following acute alcohol withdrawal relative to healthy controls. In contrast, few studies have compared neurometabolite levels between less severe, treatment-naïve AUD individuals and light drinkers or related them to recent alcohol consumption. The present study compared neurometabolite levels between treatment-naïve AUD and LD individuals. Read More

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December 2018

Multicomponent analysis of T relaxation in bovine articular cartilage at low magnetic fields.

Magn Reson Med 2018 Dec 10. Epub 2018 Dec 10.

Ilmenau University of Technology, Ilmenau, Germany.

Purpose: The multi-exponential character of T relaxation in bovine articular cartilage was investigated at low magnetic fields below 0.5 T. The ultimate aim was to identify a parameter based on the T relaxation time distribution as a biomarker to biochemical features of osteoarthritis. Read More

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December 2018

The LKB1-AMPK and mTORC1 Metabolic Signaling Networks in Schwann Cells Control Axon Integrity and Myelination: Assembling and upholding nerves by metabolic signaling in Schwann cells.

Authors:
Bogdan Beirowski

Bioessays 2018 Dec 11:e1800075. Epub 2018 Dec 11.

Hunter James Kelly Research Institute, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, 14203, USA.

The Liver kinase B1 with its downstream target AMP activated protein kinase (LKB1-AMPK), and the key nutrient sensor mammalian target of rapamycin complex 1 (mTORC1) form two signaling systems that coordinate metabolic and cellular activity with changes in the environment in order to preserve homeostasis. For example, nutritional fluctuations rapidly feed back on these signaling systems and thereby affect cell-specific functions. Recent studies have started to reveal important roles of these strategic metabolic regulators in Schwann cells for the trophic support and myelination of axons. Read More

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December 2018

The long noncoding RNA NORAD enhances the TGF-β pathway to promote hepatocellular carcinoma progression by targeting miR-202-5p.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Key Laboratory of Carcinogenesis and Cancer Invasion, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Ministry of Education, Shanghai, China.

Hepatocellular carcinoma (HCC) is one of the most fatal cancers with common features of invasion and metastasis. Recent evidence indicate that the long noncoding RNA NORAD is a potential oncogene and is significantly upregulated in several cancers. However, the general biological role and clinical value of NORAD in HCC remains unknown. Read More

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December 2018

Spectral interval optimization on rapid determination of prohibited addition in pesticide by ATR-FTIR.

Pest Manag Sci 2018 Dec 7. Epub 2018 Dec 7.

College of Science, China Agricultural University, Beijing, 100193, China.

Background: Acetamiprid, as a low toxicity pesticide, had already been extensively used to increase plant production and quality. Although fipronil had been prohibited, it was usually illicitly added to acetamiprid due to its particular insecticidal action and effect, so it was highly desirable to obtain a rapid and effective method to detect its concentration. Mid-Infrared spectroscopy (MIR) technique combined with two variable selection methods, interval combination optimization (ICO) and interval partial least squares (iPLS), were used to determinate the prohibited addition of fipronil. Read More

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December 2018

Oscillatory dynamics of cortical functional connections in semantic prediction.

Hum Brain Mapp 2018 Dec 7. Epub 2018 Dec 7.

MEG and Cortical Networks Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

An event related potential, known as the N400, has been particularly useful in investigating language processing as it serves as a neural index for semantic prediction. There are numerous studies on the functional segregation of N400 neural sources; however, the oscillatory dynamics of functional connections among the relevant sources has remained elusive. In this study we acquired magnetoencephalography data during a classic N400 paradigm, where the semantic predictability of a fixed target noun was manipulated in simple German sentences. Read More

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December 2018

Neuromuscular transmission defects in myopathies: rare but worth searching for.

Muscle Nerve 2018 Dec 7. Epub 2018 Dec 7.

Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905.

Introduction: Decremental responses in repetitive nerve stimulation (RNS) have been reported in a few hereditary myopathies. We examined the frequency of decrement in a cohort of myopathy patients.

Methods: We reviewed all patients referred for myopathy who underwent RNS between January 2007 and May 2017. Read More

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December 2018

Bioaccessibility of carotenoids from plant and animal foods.

J Sci Food Agric 2018 Dec 7. Epub 2018 Dec 7.

Institute of Food Science and Biotechnology, Chair Plant Foodstuff Technology and Analysis, University of Hohenheim, Garbenstrasse 25, D-70599 Stuttgart, Germany.

The frequent consumption of carotenoid-rich foods has been associated with numerous health benefits such as the supply of provitamin A. In order to exert these health benefits, carotenoids need to be efficiently liberated from the food matrix, micellized in the small intestine, taken up by the enterocytes, and absorbed to the human blood stream. Enormous efforts have been made to better understand these processes. Read More

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December 2018

Spectral analysis of the EBT3 radiochromic films for clinical photon and electron beams.

Med Phys 2018 Dec 8. Epub 2018 Dec 8.

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO, 63110.

Purpose: To investigate the spectral response of the EBT3 radiochromic films to different beam qualities for radiation therapy dosimetry. Dose, dose rate, and inter-batch dependencies on the spectral response of the films are investigated as well.

Methods: Pieces of EBT3 films placed between layers of solid water phantoms were irradiated with 6 and 15 MV photon beams, 6 and 10 MV-FFF photon beams, and 6 and 20 MeV electron beams at dose levels between 0. Read More

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December 2018

Evaluation of oral tranexamic acid in the treatment of melasma.

J Cosmet Dermatol 2018 Dec 9. Epub 2018 Dec 9.

Universidade de Mogi das Cruzes, Dermatology, Mogi das Cruzes, Brazil.

Background: Melasma is an acquired, chronic, recurrent hypermelanosis that occurs exclusively in areas exposed to the sun. Its treatment can be very challenging. Tranexamic acid (TA) is an inhibitor of plasmin, and it is a synthetic derivative of the amino acid lysine that reversibly blocks binding sites on the plasminogen molecule, inhibiting the plasminogen activator from converting plasminogen to plasmin. Read More

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December 2018

Hypermutagenesis in untreated adult gliomas due to inherited mismatch mutations.

Int J Cancer 2018 Dec 11. Epub 2018 Dec 11.

Institute for Refractory Cancer Research.

Hypermutagenesis refers to marked increase in the number of mutations due to continuous mutagenic process. Hypermutated tumors, have being found in several tumor types, are associated with inherited or acquired alterations in DNA repair pathways. Hypermutation has been observed in a subset of adult glioma patients as a direct result of temozolomide(TMZ)-induced mutagenesis. Read More

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December 2018

Autologous cord blood transplantation in children with acquired severe aplastic anemia.

Pediatr Transplant 2018 Dec 9:e13325. Epub 2018 Dec 9.

BeiJing Children's Hospital, Capital Medical University, Beijing, China.

Objective: To investigate the efficacy of ACBT for acquired SAA in children.

Methods: Four patients including three girls and one boy were diagnosed with acquired SAA. Their ages were 5, 3, 1, and 3 years, respectively. Read More

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December 2018

Prescribing trends and revisit rates following a pharmacist-driven protocol change for community-acquired pneumonia in an emergency department.

Int J Pharm Pract 2018 Dec 11. Epub 2018 Dec 11.

University of Pittsburgh Medical Center - Mercy Hospital, Pittsburgh, PA, USA.

Objective: To compare pharmacist-led prescribing changes and associated 30-day revisit rates across different regimens for patients discharged from an emergency department (ED) with a diagnosis of community-acquired pneumonia (CAP).

Methods: An observational, retrospective cohort analysis was conducted of patients who were discharged from an ED over a 4-year period with a diagnosis of CAP. Patient demographics, clinical characteristics, antibiotic selection and comorbidity and condition severity scores were collected for two cohorts: 2012-13 (before protocol change) and 2014-15 (post-protocol change). Read More

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December 2018

A three microRNA-based prognostic signature for small cell lung cancer overall survival.

J Cell Biochem 2018 Dec 9. Epub 2018 Dec 9.

Department of Oncology, Institute of Integrative Oncology, Tianjin Union Medicine Center, Tianjin, China.

Background: Small-cell lung cancer (SCLC) is one of the most aggressive cancers with mechanisms far from understood.

Objective: We proposed to identify valuable prognostic signature for SCLC prognosis prediction.

Methods: microRNA (miRNA) expression profiles of 42 SCLC patients were acquired from the Gene Expression Omnibus. Read More

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December 2018

A novel biomarker of serum Histidine-Rich Glycoprotein (HRG) for diagnosing and predicting prognosis of ventilator-associated pneumonia (VAP): a pilot study.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7920-7927

Department of Respiratory Medicine, Huzhou 3rd Hospital, Huzhou, Zhejiang, China.

Objective: Histidine-Rich Glycoprotein (HRG) has been reported to be associated with idiopathic pulmonary fibrosis, cancer, and sepsis as a novel biomarker. However, there is limited evidence regarding its value in diagnosing or prognosis evaluating of ventilator-associated pneumonia (VAP).

Patients And Methods: A total of 186 patients intubated in ICU and 65 healthy volunteers were enrolled in this study. Read More

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November 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

Interpretation errors in focused cardiac ultrasound by novice pediatric emergency medicine fellow sonologists.

Crit Ultrasound J 2018 Dec 9;10(1):33. Epub 2018 Dec 9.

Department of Emergency Medicine and Trauma Services, Children's National Medical Center, Washington, DC, USA.

Background: Focused cardiac ultrasound (FOCUS) is a core competency for pediatric emergency medicine (PEM) fellows. The objectives of this study were (1) to evaluate test characteristics of PEM-fellow-performed FOCUS for pericardial effusion and diminished cardiac function and (2) to assess image interpretation independent of image acquisition.

Methods: PEM fellows performed and interpreted FOCUS on patients who also received cardiology service echocardiograms, the reference standard. Read More

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December 2018

A retrospective evaluation of the risk of bias in perioperative temperature metrics.

J Clin Monit Comput 2018 Dec 8. Epub 2018 Dec 8.

Department of Anesthesiology, Vanderbilt University Medical Center, 1211 21st Avenue South, MAB 422F, Nashville, TN, 37212, USA.

The prevention and treatment of hypothermia is an important part of routine anesthesia care. Avoidance of perioperative hypothermia was introduced as a quality metric in 2010. We sought to assess the integrity of the perioperative hypothermia metric in routine care at a single large center. Read More

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December 2018
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Computed tomography pulmonary angiography and venography with a low dose of contrast medium.

Radiol Phys Technol 2018 Dec 10. Epub 2018 Dec 10.

Department of Radiology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan.

The authors developed a method to ensure sufficient opacification of pulmonary vasculature for separate depiction of arteries and veins in three-dimensional form with a small dose of contrast medium utilizing a test injection to determine optimal timing of computed tomography (CT) scanning. The dose was determined by a simulation based on a pharmacokinetic model. The contrast medium was administered at a rate of 5. Read More

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December 2018

Research Progress in MRI of the Visual Pathway in Diabetic Retinopathy.

Curr Med Sci 2018 Dec 7;38(6):968-975. Epub 2018 Dec 7.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

With an increasing incidence, diabetic retinopathy is one of the most important complications of diabetes mellitus (DM) and is also known as one of the major reasons of adult acquired blindness. It is widely accepted that the visual impairment of diabetic patients results from retinal microvascular changes. However, recent clinical experimental and neuroimaging studies suggest that the visual impairment of diabetic patients is also related to the pathophysiological changes of different parts of the visual pathway in diabetic retinopathy. Read More

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December 2018

Outcomes and resource utilization in surgery for Chiari I malformation in a national network of children's hospitals.

Childs Nerv Syst 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, Baylor College of Medicine, Division of Pediatric Neurosurgery, Texas Children's Hospital, Houston, TX, USA.

Introduction: Chiari malformation type 1 (CM-1) is a common congenital or acquired malformation of the posterior fossa. We aimed to characterize preoperative risk factors, perioperative complications, and postoperative outcomes related to CM-1 surgery in pediatric populations across a nationwide network of pediatric hospitals in the United States (US).

Methods: The Children's Hospital Association's Pediatric Health Information System (PHIS) database was used to examine patients < 21 years old in the US-based nationwide database who underwent inpatient surgery for CM-1 from 2007 to 2015. Read More

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December 2018

Predictors of cognitive function in the acute phase after aneurysmal subarachnoid hemorrhage.

Acta Neurochir (Wien) 2018 Dec 8. Epub 2018 Dec 8.

Department of Neurosurgery, Oslo University Hospital, Rikshospitalet, P.B. 4950, Nydalen, 0424, Oslo, Norway.

Background: Cognitive dysfunction is the most common form of neurological impairment after aneurysmal subarachnoid hemorrhage (aSAH) in the chronic phase. Cognitive deficits in the acute phase after aSAH, however, remain scarcely investigated. The aim of the present study was to test cognitive function and to identify medical predictors of cognitive deficits in the acute phase of aSAH. Read More

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December 2018

Predictive power of the post-treatment scans after the initial or first two courses of [Lu]-DOTA-TATE.

EJNMMI Phys 2018 Dec 10;5(1):36. Epub 2018 Dec 10.

Department of Nuclear Medicine & Biophysics, Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Background: The aim of this study was to evaluate the predictive power of the absorbed dose to kidneys after the first course of treatment with [Lu]-DOTA-TATE for neuroendocrine tumors (NETs) on the cumulative kidney absorbed dose after 3 or 4 cycles of treatment. Post-treatment scans (PTS) are acquired after each cycle of peptide receptor radionuclide therapy (PRRT) with [Lu]-DOTA-TATE for personalized radiation dosimetry in order to ensure a cumulative absorbed dose to kidneys under a safety threshold of 25 Gy. One hundred eighty-seven patients who completed treatment with [Lu]-DOTA-TATE and underwent PTS for dosimetry calculation were included in this retrospective study. Read More

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December 2018

Schema-related cognitive load influences performance, speech, and physiology in a dual-task setting: A continuous multi-measure approach.

Cogn Res Princ Implic 2018 Dec 7;3(1):46. Epub 2018 Dec 7.

Psychology of Learning with Digital Media, Institute for Media Research, Faculty of Humanities, TU Chemnitz, Straße der Nationen 12, 09111, Chemnitz, Germany.

Schema acquisition processes comprise an essential source of cognitive demands in learning situations. To shed light on related mechanisms and influencing factors, this study applied a continuous multi-measure approach for cognitive load assessment. In a dual-task setting, a sample of 123 student participants learned visually presented symbol combinations with one of two levels of complexity while memorizing auditorily presented number sequences. Read More

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December 2018

Targeting retinoblastoma protein phosphorylation in combination with EGFR inhibition in pancreatic cancer cells.

Int J Oncol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biology, Pace University, Pleasantville, NY 10570, USA.

Pancreatic ductal adenocarcinoma (PDAC) remains a particularly lethal disease that is resistant to targeted therapies. Tyrosine kinase inhibitors (TKIs), including erlotinib and gefitinib, which block the action of the human epidermal growth factor receptor type 1 receptor, provide small increases in patient survival when administered with gemcitabine. The retinoblastoma (Rb) tumor suppressor protein is an additional target in pancreatic cancer, due to its documented inactivation in PDAC. Read More

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December 2018

DeepIsoFun: A deep domain adaptation approach to predict isoform functions.

Bioinformatics 2018 Dec 10. Epub 2018 Dec 10.

Department of Computer Science and Engineering, University of California, Riverside, CA.

Motivation: Isoforms are mRNAs produced from the same gene locus by alternative splicing and may have different functions. Although gene functions have been studied extensively, little is known about the specific functions of isoforms. Recently, some computational approaches based on multiple instance learning have been proposed to predict isoform functions from annotated gene functions and expression data, but their performance is far from being desirable primarily due to the lack of labeled training data. Read More

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December 2018

European consensus-based recommendations for the diagnosis and treatment of Kawasaki disease - the SHARE initiative.

Rheumatology (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

Objectives: The European Single Hub and Access point for paediatric Rheumatology in Europe initiative aimed to optimize care for children with rheumatic diseases. Kawasaki disease (KD) is the most common cause of acquired heart disease in children and an important cause of long-term cardiac disease into adulthood. Prompt diagnosis and treatment of KD is difficult due to the heterogeneity of the disease but is crucial for improving outcome. Read More

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December 2018

Determining the origins of HIV-1 drug-resistant minority variants in people who are recently infected using phylogenetic reconstruction.

Clin Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Institute for Global Health, University College London, London, UK.

Background: Drug-resistant minority variants (DRMinVs) detected in patients who recently acquired HIV-1 can be transmitted, generated de novo through virus replication, or technical errors. The first are likely to persist and result in treatment failure while the latter two could be stochastic and transient.

Methods: Ultra-deep sequencing of plasma samples from 835 individuals with recent HIV-1 infection in the UK was performed to detect DRMinVs at mutation frequency between 2-20%. Read More

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December 2018

Cross-Species Immune Recognition Between Plasmodium vivax Duffy Binding Protein Antibodies and the Plasmodium falciparum Surface Antigen VAR2CSA.

J Infect Dis 2019 Jan;219(1):110-120

School of Public Health, University of Alberta, Edmonton, Canada.

Background: In pregnancy, Plasmodium falciparum parasites express the surface antigen VAR2CSA, which mediates adherence of red blood cells to chondroitin sulfate A (CSA) in the placenta. VAR2CSA antibodies are generally acquired during infection in pregnancy and are associated with protection from placental malaria. We observed previously that men and children in Colombia also had antibodies to VAR2CSA, but the origin of these antibodies was unknown. Read More

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January 2019

Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children's and Non-Children's Hospitals.

JAMA Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Division of Infectious Diseases, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia.

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December 2018

Epidemiology of Bloodstream Infections in Hospitalized Children in the United States, 2009-2016.

Clin Infect Dis 2018 Dec 9. Epub 2018 Dec 9.

Pediatric Emergency Medicine, Chief of Critical Care Services, Children's Minnesota, Minneapolis, MN, USA.

Background: Bloodstream infections (BSIs) cause significant morbidity and mortality in children. Recent pediatric epidemiological data may inform prevention strategies and empiric antimicrobial therapy selection.

Methods: We conducted a retrospective cohort study from 2009-2016 utilizing demographic and microbiology data on inpatients <19 years using the Premier Healthcare Database. Read More

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December 2018

[Syphilis epidemiological report. Chile, 2016].

Rev Chilena Infectol 2018 ;35(3):284-296

División de Planificación Sanitaria, Ministerio de Salud de Chile, Chile.

Syphilis is produced by Treponema pallidum, which is acquired mainly through sexual contact and transplacental, but can also be acquired by transfusion of contaminated human blood and direct accidental inoculation. The natural history of the infection is characterized by three symptomatic clinical stages: primary, secondary and tertiary syphilis; these last two are preceded by asymptomatic or latent stages of the disease: early latent syphilis and late latent syphilis. This report presents the epidemiological situation of syphilis in Chile up to 2016, using as a method the descriptive analysis of cases that entered surveillance. Read More

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January 2018

[Nosocomial urinary tract infection: an analysis beyond urinary catheterization].

Rev Chilena Infectol 2018 ;35(3):246-252

Servicio de Medicina Interna, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.

Introduction: Nosocomially acquired urinary tract infections (NAUTI) represent an important public health issue, but its characteristics when they are not catheter associated (CA-UTI) or when they take place outside intensive care units (ICU) are poorly understood.

Objectives: To determine the patients' characteristics, etiology and antimicrobial susceptibility of NAUTI, both CA-UTI and no CA-UTI, in general ward and ICU.

Methods: We conducted a retrospective analytic cross-sectional study, between 2009 and 2013, in a third level universitary hospital. Read More

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January 2018

[Bacteremic pneumococcal pneumonia in adults admitted to a general hospital. Experience in 60 cases].

Rev Med Chil 2018 Jul;146(7):839-845

Facultad de Medicina, Universidad San Sebastián, Patagonia, Chile.

Background: Bacteremic pneumococcal pneumonia (BPP) is a preventable disease with high morbimortality.

Aim: To evaluate clinical aspects and mortality on BPP patients admitted to a Chilean regional hospital.

Patients And Methods: We looked for adult patients with Streptococcus pneumoniae isolated from blood cultures between 2010 and 2014 years and reviewed clinical records of those who were admitted with pneumonia. Read More

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[Porphyria cutanea tarda. Case report].

Rev Med Chil 2018 Aug;146(8):943-946

Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Porphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. Read More

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Osseointegration of zirconium dental implants three months after insertion in rabbit femur. Histopathological study.

Rom J Morphol Embryol 2018 ;59(3):781-786

Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Romania;

Implantology is a highly researched field with a constant concern in finding and studying new implant materials. Lately, zirconium has become a very attractive alternative to the detriment of titanium, but the research results were sometimes contradictory. Thus, we considered as opportune to study the osseointegration of zirconium dental implants in rabbit femur, three months after insertion. Read More

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January 2018

Ultrasound for kidney access in percutaneous nephrolithotomy: a contemporary review.

Med Ultrason 2018 Dec;20(4):508-514

Center for Uronephrology and Renal Transplantation, Fundeni Clinical Institute, Bucharest, Romania, Urologic Surgery, Fundeni Clinical Institute,"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Nowadays percutaneous nephrolithotomy (PCNL) is the standard of care for renal staghorn calculus or large (>20 mm) pelvic or caliceal stones, as well as for the failure of other treatment options. This review aims to evaluate the contemporary use of ultrasound imaging in PCNL, by comparing it to conventional fluoroscopy, reviewing data regarding the complication and success rate of nephrostomy tract creation and stone free rate (SFR), as well as data concerning the learning curve for these procedures and cost indicators. The evidence acquired shows that the ultrasound guided access (USGA) is a comparable method with the classic fluoroscopic guided access (FGA), with a similar safety profile, with a significant reduction in radiation exposure, up to radiation free complete PCNL. Read More

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December 2018

Screening for Humoral Immunodefi ciency in Patients with Community-Acquired Pneumonia.

J Hosp Med 2018 Nov 28. Epub 2018 Nov 28.

Rochester Regional Health, Rochester, New York, USA.

Background: Immunodeficiency is an underrecognized risk factor for infections, such as community-acquired pneumonia (CAP).

Objective: We evaluated patients admitted with CAP for humoral immunodeficiency.

Design: Prospective Cohort Study. Read More

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November 2018

Panoramic azimuthal Schlumberger Vertical Electrical Sounding for fracture orientation and anisotropy quantification.

Heliyon 2018 Dec 1;4(12):e00998. Epub 2018 Dec 1.

Department of Applied Geophysics, The Federal University of Technology Akure, PMB 704, Ondo State, Nigeria.

Vertical electrical sounding (VES) data acquired with the Schlumberger configuration is popularly used to image the electrical resistivity variation with depth at a single azimuth. Apart from the random subjective choice of the single azimuthal direction by the field geophysicists, important hydrological information such as fracture orientation and anisotropic coefficients needed for understanding resultant groundwater flow direction are by design lost in the process. Panoramic (0°-360°) azimuthal VES data were acquired at two data points at the Federal University of Technology, Akure (FUTA) at angular step of 15°, making a total of 24 data sets per data point. Read More

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December 2018

A Study of Machine-Learning Classifiers for Hypertension Based on Radial Pulse Wave.

Biomed Res Int 2018 11;2018:2964816. Epub 2018 Nov 11.

Department of Basic Medical College, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Pudong New Area, Shanghai 201203, China.

Objective: In this study, machine learning was utilized to classify and predict pulse wave of hypertensive group and healthy group and assess the risk of hypertension by observing the dynamic change of the pulse wave and provide an objective reference for clinical application of pulse diagnosis in traditional Chinese medicine (TCM).

Method: The basic information from 450 hypertensive cases and 479 healthy cases was collected by self-developed H20 questionnaires and pulse wave information was acquired by self-developed pulse diagnostic instrument (PDA-1). H20 questionnaires and pulse wave information were used as input variables to obtain different machine learning classification models of hypertension. Read More

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November 2018

Severe tinnitus in a patient with acquired deafness for over 50 years: a case report.

Biopsychosoc Med 2018 26;12:17. Epub 2018 Nov 26.

2Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinamomachi, Shinjuku, Tokyo, 1608582 Japan.

Background: There have been many reports on the treatment effect of cochlear implantation and hearing aids in the treatment of tinnitus in patients with severe hearing loss. However, as far as we are aware, there are no reports of investigation of treatment approaches for the tinnitus of deaf patients whose communication is solely carried out in sign language due to a long duration of deafness.

Case Presentation: We experienced a case of severe tinnitus with bilateral deafness for more than 50 years. Read More

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November 2018

Differences in Neural Recovery From Acute Stress Between Cortisol Responders and Non-responders.

Front Psychiatry 2018 26;9:631. Epub 2018 Nov 26.

Research Division of Mind and Brain, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Adaptive recovery from a stressor fosters resilience. So far, however, few studies have examined brain functional connectivity in the aftermath of stress, with inconsistent results reported. Focusing on the immediate recovery from psychosocial stress, the current study compared amygdala resting-state functional connectivity (RSFC) before and immediately after psychosocial stress between cortisol responders and non-responders. Read More

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November 2018