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    Anti-acne drugs in phase 1 and 2 clinical trials.
    Expert Opin Investig Drugs 2017 Jul 19;26(7):813-823. Epub 2017 Jun 19.
    c Department of Venerology and Dermatology , Otto von Guericke University Magdeburg , Magdeburg , Germany.
    Introduction: Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue. Areas covered: A search for phase 1 and 2 acne treatment trials in the US National Institutes of Health database of clinical trials and the European Medicines Agency database with the key words 'acne' and 'treatment' was carried out, on 6 January 2017. Read More

    Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial.
    BMC Complement Altern Med 2017 Jun 17;17(1):318. Epub 2017 Jun 17.
    Department of Ophthalmology & Otolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
    Background: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Read More

    Evidence-based recommendations for the management of acne fulminans and its variants.
    J Am Acad Dermatol 2017 Jul;77(1):109-117
    University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
    Background: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. Read More

    Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
    J Cosmet Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, 'Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    Evolution of some indicators of systemic immunity in patients with acne while using laser therapy.
    Wiad Lek 2017;70(2):196-199
    DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY, LVIV, UKRAINE.
    Introduction: One of the important problems in modern dermatology is to improve treatment efficiency of acne being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects the psycho-emotional state of patients and their quality of life. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies. Reducing the effectiveness of skin diseases treatment, including that of acne, at present, is associated with developing resistance to drugs, which causes the use of non-drug methods in dermatology nowadays, including low-intensity laser therapy. Read More

    Clindamycin phosphate-tretinoin combination gel revisited: status report on a specific formulation used for acne treatment.
    Cutis 2017 Mar;99(3):179-183
    JDR Dermatology Research LLC/Thomas Dermatology, Las Vegas and Henderson, Nevada, and Touro University Nevada, Henderson, USA.
    Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Read More

    Oral contraceptives for acne treatment: US Dermatologists' knowledge, comfort, and prescribing practices.
    Cutis 2017 Mar;99(3):195-201
    Permanente Medical Group, Pleasanton, California, USA.
    The use of oral contraceptive pills (OCPs), which can be an effective treatment of acne in women, is poorly understood among many dermatologists. In this study, we surveyed 116 US dermatologists about their knowledge, comfort, and prescribing practices pertaining to the use of OCPs. The majority of respondents had previously prescribed OCPs and believed they were an effective treatment of acne in women. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 05;37(suppl_1):S45-S58
    Dermatologist in private practice in Miami, FL, USA.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    AbobotulinumtoxinA: A 25-Year History.
    Aesthet Surg J 2017 05;37(suppl_1):S4-S11
    Director and Founder of Toxin Science Limited, Wrexham, UK.
    During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd. Read More

    Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats.
    Tissue Cell 2017 Apr 9;49(2 Pt B):203-208. Epub 2017 Mar 9.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. Read More

    Bromoderma in an infant.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):17-19
    Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) - Porto Alegre (RS), Brazil.
    Bromoderma is a cutaneous eruption caused by the absorption of bromide. Clinical manifestations include acneiform and vegetative lesions. We report the case of an infant with bromoderma caused by the use of syrup for abdominal colic containing calcium bromide. Read More

    Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Jun 11;76(6):1068-1076.e9. Epub 2017 Mar 11.
    Department of Psychiatry, Cardinal Tien Hospital, New Taipei City, Taiwan; Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
    Background: The relationship between isotretinoin treatment for acne and depression is controversial. Quantitative analysis has not yet been conducted.

    Objective: To conduct a meta-analysis, evidence-based examination of the relationship between isotretinoin and depression. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Jun;18(3):333-341
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):415-423
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study.
    Arch Dermatol Res 2017 Apr 8;309(3):159-167. Epub 2017 Feb 8.
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Apr;18(2):169-191
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    Monogenic Auto-inflammatory Syndromes: A Review of the Literature.
    Iran J Allergy Asthma Immunol 2016 Dec;15(6):430-444
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Auto-inflammatory syndromes are a new group of distinct hereditable disorders characterized by episodes of seemingly unprovoked inflammation (most commonly in skin, joints, gut, and eye), the absence of a high titer of auto-antibodies or auto-reactive T cells, and an inborn error of innate immunity. A narrative literature review was carried out of studies related to auto-inflammatory syndromes to discuss the pathogenesis and clinical manifestation of these syndromes. This review showed that the main monogenic auto-inflammatory syndromes are familial Mediterranean fever (FMF), mevalonate kinase deficiency (MKD), Blau syndrome, TNF receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), and pyogenic arthritis with pyoderma gangrenosum and acne (PAPA). Read More

    A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria.
    Phytother Res 2017 Mar 26;31(3):410-417. Epub 2017 Jan 26.
    School of Pharmacy, De Montfort University, Leicester, UK.
    Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Read More

    Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
    Microbiol Immunol 2017 Jan;61(1):42-44
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
    The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. Read More

    Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds.
    Int J Mol Sci 2017 Jan 17;18(1). Epub 2017 Jan 17.
    Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania.
    The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i. Read More

    Results of a Phase 2, Randomized,Vehicle-Controlled Study Evaluating the Efficacy,Tolerability, and Safety of Daily or Twice Daily SB204 for the Treatment of Acne Vulgaris.
    J Drugs Dermatol 2016 Dec;15(12):1496-15027
    Objective: This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris.

    Methods: Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12). Read More

    Combination Therapy for Acne Scarring: Personal Experience and Clinical Suggestions.
    J Drugs Dermatol 2016 Nov;15(11):1413-1419
    Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results. Read More

    Acne Treatment With 3-Step Broadband Light Protocol.
    J Drugs Dermatol 2016 Nov;15(11):1382-1388
    Background And Objective: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avoid potential side effects of systemic acne treatments and the risks and uncertainties associated with laser and light treatments to date. The protocol also addresses acne scarring and, with appropriate modi cations, all skin types.

    Methods: The protocol consists of 6 to 8 treatments performed with a single device that allows the user to select wavelength, spot size, uence, and pulse duration. Read More

    Integrated Cooling-Vacuum-Assisted Non-Fractional 1540 nm Erbium:Glass Laser is Effective in Treating Acne Scars.
    J Drugs Dermatol 2016 Nov;15(11):1359-1363
    Introduction: Acne scars are a common result of in ammatory acne, affecting many patients worldwide. Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of dermal collagen. Mid-infrared laser skin interaction is characterized by its modest absorption in water and nite penetration to the mid-dermis. Read More

    Comparison of the Cutaneous Thermal Signatures Over Twenty-Four Hours With a Picosecond Alexandrite Laser Using a Flat or Fractional Optic.
    J Drugs Dermatol 2016 Nov;15(11):1347-1352
    Introduction: This study explored immediate heat signatures with different passing techniques and the delayed thermal data points with the picosecond Alexandrite laser with the 6mm at and fractional optic during and after treatment. We sought to clarify the im- mediate effects of heating and understand the thermal and short term clinical difference when using these optics.

    Results: There were no immediate differences or a signi cant temperature rise with different passing techniques using the at or the fractional optic. Read More

    Spotlight on the Use of Nitric Oxide in Dermatology: What Is It? What Does It Do? Can It Become an Important Addition to the Therapeutic Armamentarium for Skin Disease?
    J Drugs Dermatol 2017 Jan;16(1):s4-s10
    Nitric oxide (NO) is a diatomic gas that is synthesized within and released by multiple host cell types functioning to provide a variety of physiologic and homeostatic effects. Nitric oxide exhibits a variety of effects that relate significantly with outcomes that can provide therapeutic benefit if properly formulated and released. These include anti-inflammatory, immunomodulatory, antimicrobial, vasodilatory properties, and effects that are beneficial to wound healing. Read More

    Multiple Activities of Punica granatum Linne against Acne Vulgaris.
    Int J Mol Sci 2017 Jan 12;18(1). Epub 2017 Jan 12.
    PhD Program for Clinical Drug Discovery of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. Read More

    Chemical pharmacotherapy options for managing adult acne.
    Expert Opin Pharmacother 2017 Feb 23;18(3):263-273. Epub 2017 Jan 23.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Read More

    Modern management of acne.
    Med J Aust 2017 Jan;206(1):41-45
    Royal North Shore Hospital, Sydney, NSW.
    Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects. Read More

    Performing Skin Microbiome Research: A Method to the Madness.
    J Invest Dermatol 2017 Mar 4;137(3):561-568. Epub 2017 Jan 4.
    Institute of Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München-German Research Center for Environmental Health, Augsburg, Germany; Christine Kühne Center for Allergy Research and Education, Davos, Switzerland.
    Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis. The need for common language, effective study design, and validated methods is critical for high-quality standardized research. Features, unique to skin, pose particular challenges when conducting microbiome research. Read More

    The Use of Cosmeceuticals in Acne: Help or Hoax?
    Am J Clin Dermatol 2017 Apr;18(2):159-163
    Department of Dermatology, Penn State/Hershey Medical Center, HU14, 500 University Drive, Hershey, PA, 17022, USA.
    The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid. Read More

    Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.
    J Am Acad Dermatol 2017 Jan 28;76(1):33-39. Epub 2016 Oct 28.
    Windsor Clinical Research Inc, Windsor, Ontario, Canada.
    Background: Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.

    Objectives: Safety and efficacy of OG 7. Read More

    Treatment of Acne Scars on Darker Skin Types Using a Noninsulated Smooth Motion, Electronically Controlled Radiofrequency Microneedles Treatment System.
    Dermatol Surg 2017 Jan;43 Suppl 1:S64-S69
    Department of Dermatology, Jubilee Mission Medical College, Thrissur, India and Pudukadan's Dermalaser Centre, Thrissur, India.
    Background: Noninvasive technologies for treating acne scars use radiofrequency (RF)-emitting microneedles for both mechanical disruption of fibrotic strands and heat-mediated collagen remodeling.

    Objective: Efficacy and safety evaluation of electronically controlled noninsulated RF microneedling system on acne scars in patients with dark skin.

    Methods: Nineteen patients, 24 to 51 years old, skin types III to V, with acne scars were enrolled in the study. Read More

    Fractional Erbium-Doped Yttrium Aluminum Garnet Laser Versus Microneedling in Treatment of Atrophic Acne Scars: A Randomized Split-Face Clinical Study.
    Dermatol Surg 2017 Jan;43 Suppl 1:S47-S56
    *National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt; †Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: Ablative fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser and microneedling have been popularized in recent years and their effectiveness and side effects individually reported. No previous study, however, has directly compared the efficacy and safety between the 2 different treatments.

    Objective: To compare the efficacy and safety of the ablative fractional Er:YAG laser and microneedling for the treatment of atrophic acne scars. Read More

    Laser Safety in Isotretinoin Use: A Survey of Expert Opinion and Practice.
    Dermatol Surg 2017 Mar;43(3):357-363
    *SkinCare Physicians, Chestnut Hill, Massachusetts; †Feinberg School of Medicine, Department of Dermatology, Northwestern University, Chicago, Illinois.
    Background: Reports of poor wound healing in the setting of isotretinoin treatment have created a conservative standard of care in which laser and phototherapy treatment of patients receiving isotretinoin is relatively contraindicated.

    Objective: A survey of 220 nationally recognized experts in cutaneous laser surgery was conducted to evaluate physician experience and opinion pertaining to laser and light procedures in patients treated with isotretinoin, including perceived risk and actual complications.

    Results: There was a 42% response rate. Read More

    Dapsone 7.5% Gel: A Review in Acne Vulgaris.
    Am J Clin Dermatol 2017 Feb;18(1):139-145
    Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
    Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2017 Mar 21;7(1):133-141. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors.
    Pediatr Dermatol 2017 Jan 16;34(1):90-94. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children.

    Methods: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. Read More

    Acne: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):710-716. Epub 2016 Jul 9.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; Department of Pediatrics, University of Connecticut Health Science Center, Farmington, CT.
    Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endocrine or hormonal tests are indicated. We also discuss age-dependent treatment considerations, including appropriate oral antimicrobial regimens and the proper dosing of isotretinoin in young children versus teenagers and adults. Read More

    Nutrition and skin: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):698-709. Epub 2016 Jul 9.
    Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA.
    There has been a surge of new data regarding the pathophysiology of skin diseases. We are appreciating the sophisticated interplay among the skin, the immune system, and the environment. More elegant and highly specific medicines have been designed to target certain immune mediators of the adaptive immune system. Read More

    Ethnic skin: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):690-697. Epub 2016 Jul 12.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:
    There are numerous skin conditions that occur commonly in children with ethnic skin, including vitiligo, progressive macular hypomelanosis, pityriasis alba, acne keloidalis nuchae, pseudofolliculitis barbae, and keloids. Though these conditions occur in both children and adults, children may have different patterns of clinical presentation and response to therapy. In caring for such patients, important treatment considerations include side effects of systemic medications and tolerability of invasive procedures. Read More

    Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes.
    Anaerobe 2017 Feb 5;43:61-68. Epub 2016 Dec 5.
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. Electronic address:
    Virulence enzymes and biofilm a play crucial role in the pathogenesis of Propionibacterium acnes, a major causative agent of acne vulgaris. In the present study, the effects of rhodomyrtone, a pure compound identified from Rhodomyrtus tomentosa (Aiton) Hassk. leaves extract against enzyme production and biofilm formation production by 5 clinical isolates and a reference strain were evaluated. Read More

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