AAPS PharmSciTech 2021 Apr 6;22(3):125. Epub 2021 Apr 6.
Department of Food and Environment Engineering, Heilongjiang East University, 1 Hanan Road, Harbin, 150086, People's Republic of China.
The main objective of the study was to prepare the microemulsions containing adapalene (MEs-Ap) to enhance epidermal penetration, dermal retention, and local bioavailability compared with the commercial preparation. The optimal formulations were selected by solubility experiments, pseudo-ternary phase diagram, and percutaneous permeation experiments and the physiochemical properties were also investigated. Then, the study of permeability, retention, safety, pharmacodynamics, and pharmacokinetics in the skin for MEs-Ap compared with the commercial preparation were researched. Read More