12,228 results match your criteria Acneiform Eruptions


Observation for clinical effect of acupuncture combined with conventional therapy in the treatment of acne vulgaris.

Medicine (Baltimore) 2020 May;99(18):e19764

Department of Dermatology, Huabei Petroleum General Hospital, China.

Introduction: Acne vulgaris is a chronic inflammatory disease of the sebaceous glands that occurs in adolescent men and women. In recent years, the incidence of acne has increased year by year, so it is of great significance to find a precise and effective treatment and further explore its possible mechanism of action. The purpose of this study will be to explore a treatment method that has both traditional Chinese medicine characteristics and significant effects, and provides a higher level of evidence for acupuncture for acne vulgaris. Read More

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http://dx.doi.org/10.1097/MD.0000000000019764DOI Listing

Propranolol-induced acneiform eruptions: revisiting a rare cutaneous side effect.

Postgrad Med J 2020 Apr 17. Epub 2020 Apr 17.

Department of Psychiatry, RG Kar Medical College and Hospital, Kolkata, India.

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http://dx.doi.org/10.1136/postgradmedj-2020-137756DOI Listing
April 2020
1.549 Impact Factor

Poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Wiad Lek 2020 ;73(2):289-292

Sumy State University, Sumy, Ukraine.

Objective: The aim of the study was to evaluate the role of poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Patients And Methods: Materials and methods: The study included 140 people with a diagnosis of moderate acne: group 1 - patients with AV, group 2 - patients with AV + Demodicosis, group3- AV + Demodicosis + functional gallbladder disorder (FGD). Biochemical analysis of lipid profile and liver enzymes, bilirubin was performed with semi-automatic analyzer HUMALYZER 3000. Read More

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Follicular occlusion triad: an isotopic response or adverse effect of rituximab?

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Department of Dermatology, University of Illinois at Chicago, Chicago, IL.

Follicular occlusion triad is a symptom complex of three conditions with a similar pathophysiology including hidradenitis suppurativa (HS), dissecting cellulitis of the scalp, and acne conglobata. Although the exact pathogenesis of the triad is unknown, it appears to be related to follicular occlusion in areas with apocrine glands. Wolf isotopic response refers to the occurrence of a new dermatosis at the site of another, unrelated, previously healed dermatosis. Read More

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February 2020

Acne Vulgaris: Treatment Made Easy for the Primary Care Physician.

Pediatr Ann 2020 Mar;49(3):e109-e115

Acne is the most common skin condition observed in adolescent and preadolescent patients. Pediatric providers are on the forefront of managing the disease, often as a secondary concern in a busy practice. Therefore, every provider needs to have an acne treatment plan that is effective, easy to communicate, and simple to follow. Read More

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http://dx.doi.org/10.3928/19382359-20200211-01DOI Listing

Twelve cases of acneiform eruptions while on anti-CTLA4 therapy.

Support Care Cancer 2020 Jun 9;28(6):2499-2502. Epub 2020 Mar 9.

University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, FCT 11.5000, Unit 1452, Houston, TX, 77030-4009, USA.

We present the first detailed report of acneiform eruptions in patients on CTLA-4 inhibitor therapy. Acneiform eruptions commonly occur (up to 75-100%) as a cutaneous adverse event associated with EGFR inhibition; however, acneiform eruptions have not been highly reported as a cutaneous adverse event associated with CTLA-4 inhibitor therapy. We conducted a retrospective chart review of our institution's database to assess cutaneous adverse events associated with ipilimumab and tremelimumab, identifying 12 patients with acneiform eruptions (2 on tremelimumab and 10 on ipilimumab). Read More

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http://dx.doi.org/10.1007/s00520-020-05381-5DOI Listing

Dosages of androgenic hormones in adolescent patients with severe acne.

Rev Assoc Med Bras (1992) 2020 Jan;66(1):36-41

. Laboratório de Análises Clínicas da Faculdade de Medicina do ABC, Av. Príncipe de Gales, 821, CEP 09060-650, Santo André, SP, Brasil.

Objective: Acne vulgaris in female adolescents, when severe or accompanied by other signs of androgenization, may represent a sign of hyperandrogenemia often underdiagnosed, which will have harmful consequences for adult life. The objective of this cross-sectional and retrospective study was to demonstrate the incidence of hormonal changes in the cases of female adolescents with severe or extensive acne, with or without other signs of hyperandrogenism, and propose a hormonal research pattern which should be indicated in order to detect early hyperandrogenemia.

Methods: The medical records of 38 female patients aged between 9 and 15 years old with grade II and/or III acne were analyzed. Read More

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http://dx.doi.org/10.1590/1806-9282.66.1.36DOI Listing
January 2020

Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis.

An Bras Dermatol 2020 Mar - Apr;95(2):187-193. Epub 2020 Feb 12.

Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey.

Background: Demodex mites are found on the skin of many healthy individuals. Demodex mites in high densities are considered to play a pathogenic role.

Objective: To investigate the association between Demodex infestation and the three most common facial dermatoses: acne vulgaris, rosacea and seborrheic dermatitis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175027PMC

PsAPASH: a rare and recent autoinflammatory syndrome associated with hidradenitis suppurativa.

An Bras Dermatol 2020 Mar - Apr;95(2):203-206. Epub 2020 Jan 21.

Department of Dermatology, Hospital Universitário Lauro Wanderley, João Pessoa, PB, Brazil.

Hidradenitis suppurativa is a chronic inflammatory skin disease, which affects 1% of the population, being more common in young, obese and smokers, and mainly affects armpits and groin, with formation of pustules, nodules, abscesses, scars and fistulas. Recently, its association with other autoimmune diseases such as psoriasis, psoriatic arthritis, pyoderma gangrenosum, pyogenic arthritis and ulcerative colitis have been reported. These associated forms are usually resistant to standard treatment, with immunobiologicals as promising therapy. Read More

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http://dx.doi.org/10.1016/j.abd.2019.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175036PMC

High-throughput sequencing reveals the diversity of TCR β chain CDR3 repertoire in patients with severe acne.

Mol Immunol 2020 04 8;120:23-31. Epub 2020 Feb 8.

Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, PR China; Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, PR China. Electronic address:

Acne is a common chronic inflammatory skin disease, and the inflammation immune response runs through all stages of acne lesions. In this study, we use a combination of multiplex-PCR and high-throughput sequencing technologies to analyze T cell receptor β chain CDR3 (complementarity-determining region 3) in peripheral blood isolated from severe acne patients. Once compared with healthy controls, we propose to identify acne-relevant CDR3 peptides. Read More

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http://dx.doi.org/10.1016/j.molimm.2020.01.024DOI Listing

Acne Vulgaris in an Undergraduate Population in Nigeria.

West Afr J Med 2020 Jan-Mar;37(1):62-66

Department of Medicine, Lagos University Teaching Hospital, Lagos, Nigeria.

Background: Acne vulgaris is a chronic inflammatory disease of the pilo-sebaceous unit. It affects teenagers and young adults. Factors which can provoke or aggravate acne include cosmetic agents, medications, and sunlight. Read More

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When bugs and drugs conspire: driving acneiform skin toxicity.

J Clin Invest 2020 Mar;130(3):1090-1092

Therapy with antineoplastic agents that inhibit EGFR and MEK is frequently limited by cutaneous adverse reactions, most commonly acne-like eruptions. In this issue of the JCI, Satoh et al. define a mechanism for acneiform skin toxicity wherein EGFR/MEK inhibitors cooperate with the skin commensal Cutibacterium acnes to induce IL-36γ in keratinocytes via the combined actions of Krüppel-like factor 4 and NF-κB transcription factors at the IL-36γ promoter, resulting in neutrophil recruitment. Read More

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http://dx.doi.org/10.1172/JCI133787DOI Listing

Trifarotene (Aklief) - a new topical retinoid for acne.

Authors:

Med Lett Drugs Ther 2019 Dec;61(1587):195-197

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December 2019

Integrated targeted serum metabolomic profile and its association with gender, age, disease severity, and pattern identification in acne.

PLoS One 2020 17;15(1):e0228074. Epub 2020 Jan 17.

Department of Ophthalmology & Otolaryngology & Dermatology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of Korea.

Background: Westernized diet and nutritional metabolism are important in acne pathogenesis, especially in adult patients. However, clinical and basic data are lacking. Pattern identification (PI) is a tool that results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs in traditional medicine. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228074PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968861PMC

Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris.

AAPS PharmSciTech 2020 Jan 8;21(2):61. Epub 2020 Jan 8.

Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University), Deralakatte, Mangaluru, Karnataka, 575018, India.

Adapalene-loaded transfersome gel containing vitamin C as a combination therapy for the management of acne vulgaris was developed in the present study. The transfersome was prepared by reverse-phase evaporation, and the effect of various process parameters were investigated by the Design of Experiment (DOE) approach and optimized based on the particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE). The selected tranfersomes were further evaluated for their thermal behavior and morphology by transmission electron microscopy and turbidity measurements and incorporated into a gel with/without vitamin C. Read More

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https://www.researchgate.net/publication/338472471_Developme
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http://dx.doi.org/10.1208/s12249-019-1518-5DOI Listing
January 2020
1.776 Impact Factor

Cutaneous Adverse Drug Reactions to Targeted Chemotherapeutic Drugs: A Clinico-Epidemiological Study.

Indian J Dermatol 2019 Nov-Dec;64(6):471-475

Department of Dermatology, B.J. Medical College and Civil Hospital, Ahmedabad, Gujarat, India.

Background: Targeted chemotherapeutic drugs have led to a remarkable improvement in the survival of cancer patients but also have resulted in the increased incidence of uncommon but specific muco-cutaneous adverse effects.

Aims: This study aimed to highlight the spectrum of such cutaneous adverse drug reactions and to derive a causal association.

Materials And Methods: A hospital-based, descriptive study was carried out in the dermatology outpatient department between August 2016 and July 2018, on patients referred from the state cancer institute, who developed muco-cutaneous lesions after the initiation of targeted chemotherapeutic drugs. Read More

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http://dx.doi.org/10.4103/ijd.IJD_491_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6862361PMC
January 2020

The Fate of Active Acne and Acne Scars Following Treatment With Fractional Radiofrequency

Authors:
Bruce E. Katz

J Drugs Dermatol 2019 Dec;18(12):1268-1272

INTRODUCTION: Acne vulgaris (AV) is a common skin disorder that may result in long-lasting acne scars. Techniques such as delivering fractional radiofrequency (RF) energy through miniature pins or needles have been utilized to manage active acne and acne scars. Skin restoration through dermal remodeling, neo-collagenesis, neo-elastogenesis, and epidermal re-newal are typical results of such treatments. Read More

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December 2019

Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate and Severe Acne Vulgaris in Females: Effect of Age on Efficacy and Tolerability

J Drugs Dermatol 2019 Dec;18(12):1218-1225

BACKGROUND: While it is generally considered to be a disease of adolescence, acne affects an increasing number of adults, especially women. Although data exist on the use of retinoids in adult females, there is no universal agreement as to the age of onset of adult female acne, or data on the efficacy and tolerability dependent on age. A novel tretinoin 0. Read More

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December 2019

Truncal Acne: A Neglected Entity

J Drugs Dermatol 2019 Dec;18(12):205-1208

Truncal acne – acne vulgaris involving the chest, back, or shoulders – is thought to be present in more than half of patients with acne. Because the study of acne has been focused on the face, there are sparse data in the literature about the clinical characteristics and management options for truncal acne. It is thought that the pathogenic process is similar between the face and the back, suggesting that treatments studied on the face may be suitable for use on the back. Read More

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December 2019

Facing Crohn's: A Rare Association.

Gastroenterology 2020 03 13;158(4):829-830. Epub 2019 Dec 13.

Department of Medicine, Division of Gastroenterology, NYU Langone Health, New York, New York.

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http://dx.doi.org/10.1053/j.gastro.2019.11.300DOI Listing

Proteomic and Phosphoproteomic Analysis Reveals that Neurokinin-1 Receptor (NK1R) Blockade with Aprepitant in Human Keratinocytes Activates a Distinct Subdomain of EGFR Signaling: Implications for the Anti-Pruritic Activity of NK1R Antagonists.

Medicines (Basel) 2019 Dec 9;6(4). Epub 2019 Dec 9.

Department of Anesthesiology, Duke University, Durham, NC 27710, USA.

: Epidermal growth factor receptor (EGFR) inhibitors can cause serious cutaneous toxicities, including pruritus and papulopustular acneiform skin eruptions. Increasingly, the neurokinin-1 receptor (NK1R) antagonist aprepitant is being utilized as an anti-pruritic agent in the treatment of EGFR-inhibitor induced pruritus. Aprepitant is believed to reduce itching by blocking NK1R on the surface of dermal mast cells. Read More

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http://dx.doi.org/10.3390/medicines6040114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963385PMC
December 2019

Chloracne and Hyperpigmentation Caused by Exposure to Hazardous Aryl Hydrocarbon Receptor Ligands.

Int J Environ Res Public Health 2019 12 3;16(23). Epub 2019 Dec 3.

Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashiku, Fukuoka 812-8582, Japan.

Dioxins and dioxin-like compounds are environmental pollutants that are hazardous to human skin. They can be present in contaminated soil, water, and air particles (such as ambient PM). Exposure to a high concentration of dioxins induces chloracne and hyperpigmentation. Read More

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http://dx.doi.org/10.3390/ijerph16234864DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926551PMC
December 2019

From genome-wide association to biological explanation.

Br J Dermatol 2019 12;181(6):1113-1114

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

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http://dx.doi.org/10.1111/bjd.18462DOI Listing
December 2019

Adolescents' self perceived acne-related beliefs: from myth to science.

An Bras Dermatol 2019 Nov - Dec;94(6):684-690. Epub 2019 Oct 26.

Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Acne vulgaris is recognized as the third most prevalent skin disease worldwide, with highest prevalence among adolescents. Beliefs and perceptions of adolescents about acne are incoherent in the literature.

Objectives: To assess the most frequently reported acne-related beliefs in adolescents in order to focus on misconceptions and develop proper recommendations. Read More

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http://dx.doi.org/10.1016/j.abd.2019.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939091PMC
January 2020

Chronic antibiotic use for severe acne might increase breast cancer risk.

Authors:
Kadri Altundag

J BUON 2019 Sep-Oct;24(5):2206-2207

MKA Breast Cancer Clinic, Tepe Prime, Cankaya, 06800 Ankara, Turkey.

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Topical Calcium Channel Blockers: A Potential New Treatment for Acne.

Authors:
Farnoosh Nozari

Skinmed 2019;17(5):347-348. Epub 2019 Sep 1.

Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

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Essential oils as topical anti-infective agents: A systematic review and meta-analysis.

Complement Ther Med 2019 Dec 24;47:102224. Epub 2019 Oct 24.

Department of Pharmacology, Mbarara University of Science and Technology, Mbarara, P.O.Box 1410, Uganda. Electronic address:

Objective: This study summarized evidence on the efficacy and safety of essential oils (EOs) in the treatment of topical infections.

Design And Setting: Systematic review of clinical trials conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. Electronic databases of the Cochrane, PubMed, EMBASE, Web of Science, and Scopus were searched from inception to November 2018. Read More

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http://dx.doi.org/10.1016/j.ctim.2019.102224DOI Listing
December 2019

Epidermal growth factor receptor (EGFR) inhibitor induced purpuric drug eruption: Three case reports.

Medicine (Baltimore) 2019 Nov;98(47):e18112

Department of Dermatology, Kaohsiung Veterans General Hospital.

Introduction: Purpuric drug eruption (PDE) is an uncommon, clinically distinct side effect of epidermal growth factor receptor (EGFR) inhibitors.

Patient Concerns: Unlike acneiform eruption, which arises from hair follicles mainly in the head and neck area, PDE starts from xerosis cutis, primarily in the lower extremities and is not associated with hair follicles. Herein, we report 3 cases of 3 patients who had received EGFR inhibitor and were hospitalized for PDE later. Read More

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http://dx.doi.org/10.1097/MD.0000000000018112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6882566PMC
November 2019
5 Reads

Anti-acne vulgaris effect including skin barrier improvement and 5α-reductase inhibition by tellimagrandin I from Carpinus tschonoskii.

BMC Complement Altern Med 2019 Nov 21;19(1):323. Epub 2019 Nov 21.

Laboratory of Pharmacognosy and Natural Product derived Medicine, College of Pharmacy, Chung-Ang University, Seoul, 156-756, Republic of Korea.

Background: Carpinus tschonoskii (CT) has been previously studied for various activities in the improvement of skin diseases. In the present study, we examined the in vitro anti-acne vulgaris (AV) effect of CT leaves (CTL) and tellimagrandin I (TI), one of the main ellagitannins from CT, including skin barrier improvement and 5α-reductase inhibitory activity.

Methods: To test the anti-AV activities of CTL and TI, firstly, anti-oxidative and anti-inflammatory activities including DPPH radical scavenging activity, nitric oxide (NO) inhibitory activity, and cytokines [interleukin (IL)-6 and IL-8] were tested. Read More

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http://dx.doi.org/10.1186/s12906-019-2734-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6869165PMC
November 2019

Efficacy and Tolerability of a Novel Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate or Severe Acne Vulgaris in Adult Females

J Drugs Dermatol 2019 Nov;18(11):1147-1154

Background: A novel tretinoin 0.05% lotion formulation has been shown to be efficacious and well-tolerated, and especially effective in adult female acne patients. While it is perhaps counter-intuitive that patients with more severe disease would show clinically significant improvement with topical monotherapy, topical retinoids have been shown to offer realistic treatment options in these patients. Read More

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November 2019

A Cohort Study Using a Facial Cleansing Brush With Acne Cleansing Brush Head and a Gel Cleanser in Subjects With Mild-to-Moderate Acne and Acne-Prone Skin

J Drugs Dermatol 2019 Nov;18(11):1140-1145

Introduction: Acne vulgaris is a highly prevalent skin condition that can adversely affect the quality of life. Acne-predisposed skin is in a state of subclinical inflammation leading to skin barrier dysfunction. A multi-center cohort study was designed to evaluate clinical efficacy and safety of twice daily facial cleansing using an oscillatory sonic brush, acne brush head, and cleansing gel for 4 weeks. Read More

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November 2019

Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris: Impact of Gender and Race on Efficacy and Safety

J Drugs Dermatol 2019 Nov;18(11):1128-1138

Background: There has been an increasing interest in gender and racial differences both in the pathogenesis and treatment of acne vulgaris (acne), and postinflammatory hyperpigmentation (PIH) is a major concern in patients of color. Female acne patients report more anxiety and depression with acne improvement positively influencing Quality of Life (QoL) than their male counterparts, and there are differences in acne presentation. The first lotion formulation of tretinoin was developed using novel polymeric emulsion technology to provide an important alternative option to treat these acne patients, especially those who may be sensitive to the irritant effects of other tretinoin formulations. Read More

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November 2019

Combined 400-600nm and 800-1200nm Intense Pulsed Phototherapy of Facial Acne Vulgaris

J Drugs Dermatol 2019 Nov;18(11):1116-1122

Background and Objective: Laser and light-based therapies are relatively new treatment options for acne vulgaris patients. Intense pulsed light (IPL) is believed to exploit the photosensitivity of P. acnes residing in the pilosebaceous units at lower wavelengths and induce anti-inflammatory effects by influencing cytokine release at higher wavelengths. Read More

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November 2019

Safety and Effectiveness of Microfocused Ultrasound With Visualization for the Correction of Moderate to Severe Atrophic Acne Scars

J Drugs Dermatol 2019 Nov;18(11):1109-1114

Objective: To assess the effectiveness of microfocused ultrasound with visualization (MFU-V) for treating moderate to severe atrophic acne scars. Design: Healthy subjects (N=20) seeking correction of moderate to severe atrophic acne scars on the cheeks and/or temples were enrolled. Scars were predominantly rolling- and boxcar-type, affecting an area ≥5. Read More

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November 2019
5 Reads

Critical analysis of features and quality of applications for clinical management of acne.

Dermatol Online J 2019 10 15;25(10). Epub 2019 Oct 15.

Schulich School of Medicine and Dentistry-Western University, London, Ontario University of Windsor, Windsor, Ontario.

Background: Mobile medical applications (apps) for clinical management of medical conditions are increasing in prevalence. Our aim was to identify features and overall quality of acne apps that could facilitate clinical management.

Methods: We established 10 pertinent features (6 essential and 4 desirable) for an acne app through literature search and nominal group discussion. Read More

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October 2019

Efficacy of Isotretinoin and Antihistamine versus Isotretinoin Alone in the Treatment of Moderate to Severe Acne: A Randomised Control Trial.

Authors:
D Pandey S Agrawal

Kathmandu Univ Med J (KUMJ) 2019 Jan.-Mar;17(65):14-19

Department of Dermatology and Venereology, BP Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal.

Background Acne vulgaris has considerable impact on physical and psychological health. Isotretinoin is considered most effective drug available for acne therapy but with limited acceptance because of its adverse effects. Antihistamine inhibits inflammatory mediators, Propionibacterium acne induced itching, reduction of squalene and sebum in sebocyte, reduces anxiety and further lessens hormonal derangement and inhibits mast cell induced fibrosis and scars. Read More

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February 2020

Use of a monofilament debridement pad in the treatment of acne vulgaris.

J Wound Care 2019 Nov;28(11):780-783

Lohmann & Rauscher GmbH & Co. KG, Irlicher Str. 55, 56567 Neuwied, Germany.

Objective: Acne vulgaris (acne) presents with increased oil-sebum secretion and subsequent formation of comedones, papules, pustules and nodules. Skin cleansing is part of the daily routine to improve skin condition. A monofilament debridement pad has shown to be effective when used for wound debridement and skin cleansing in dermatological conditions. Read More

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http://dx.doi.org/10.12968/jowc.2019.28.11.780DOI Listing
November 2019
1.110 Impact Factor

Sarecycline hydrochloride for the treatment of acne vulgaris.

Drugs Today (Barc) 2019 Oct;55(10):615-625

Division of Microbiology, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh, India.

Sarecycline hydrochloride (Seysara) is a novel, narrow-spectrum tetracycline derivative approved by the U.S. Food and Drug Administration (FDA) in October 2018 for the treatment of inflammatory non-nodular moderate to severe acne vulgaris. Read More

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http://dx.doi.org/10.1358/dot.2019.55.10.3045040DOI Listing
October 2019

Trifarotene: First Approval.

Authors:
Lesley J Scott

Drugs 2019 Nov;79(17):1905-1909

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Topical trifarotene (Aklief) is a first-in-class, fourth-generation retinoid [selective retinoic acid receptor (RAR)-γ agonist] being developed by Galderma Research and Development LLC for the treatment of acne vulgaris. In October 2019 trifarotene received its first global approval in the USA for the topical treatment of acne vulgaris in patients 9 years of age and older. This article summarizes the milestones in the development of trifarotene leading to its first global approval for acne vulgaris. Read More

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http://dx.doi.org/10.1007/s40265-019-01218-6DOI Listing
November 2019

Oesophageal ulceration in adult patients treated with doxycycline for acne vulgaris.

J Int Med Res 2019 Dec 10;47(12):6404-6409. Epub 2019 Nov 10.

Department of Gastroenterology, The Third People's Hospital of Hangzhou, Hangzhou, China.

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http://dx.doi.org/10.1177/0300060519881272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045682PMC
December 2019

Use of oral isotretinoin to treat acne in the public system: a hospital-based retrospective cohort.

Sao Paulo Med J 2019;137(4):363-368. Epub 2019 Oct 31.

MD, PhD. Dermatologist and Associate Professor, Department of Dermatology, Escola Paulista de Medina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

Background: Acne needs to be treated early to prevent negative psychosocial impacts. In severe or moderate forms, which tend to leave scars, oral isotretinoin is the first-line therapy. However, concern about its adverse events, especially in developed countries, delays effective treatment. Read More

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http://dx.doi.org/10.1590/1516-3180.2018.054405072019DOI Listing

Atopic dermatitis in adolescents with skin of color.

Cutis 2019 Sep;104(3):164-168

Department of Dermatology, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Atopic dermatitis (AD) is a common chronic inflammatory dermatosis of childhood that typically improves during adolescence but can be lifelong. Black children are at 6-times greater risk for severe AD than white children, and AD may lead to a greater negative impact on quality of life (QOL) in patients with skin of color. For these reasons, it is important for dermatologists to consider the various issues associated with AD that adolescents with skin of color may face. Read More

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September 2019
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Establishment of an Anti-acne Vulgaris Evaluation Method Based on TLR2 and TLR4-mediated Interleukin-8 Production.

In Vivo 2019 Nov-Dec;33(6):1929-1934

Cell-Based Drug and Health Product Development Research Unit, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand

Background/aim: To date, no cell-based assay that focuses on the prime cause of acne initiation through activation of toll-like receptor2 and 4 and interleukin-8 (IL-8) production exists. Herein, we present an assay that evaluates acne by determining TLR2 and 4 expression and activation.

Materials And Methods: Viability of keratinocytes was determined by the MTT assay. Read More

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http://dx.doi.org/10.21873/invivo.11687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899138PMC

Comment on 'The effects of isotretinoin therapy on serum homocysteine, folate and vitamin B12 levels in patients with acne': may retinoids be useful to treat hyperhomocysteinemia found in patients affected by hidradenitis suppurativa?

J Eur Acad Dermatol Venereol 2020 03 19;34(3):e120-e121. Epub 2019 Nov 19.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Via Pansini 5, Napoli, Italy.

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http://dx.doi.org/10.1111/jdv.16039DOI Listing

Analysis of acne-related judicial precedents from 1997 to 2018 in South Korea.

J Dermatol 2019 Dec 23;46(12):1210-1214. Epub 2019 Oct 23.

Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.

Medicolegal disputes are increasing in practical medicine. Medications or procedures related to acne could lead to medical malpractice. This study analyzed medical litigation associated with acne in South Korea. Read More

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http://dx.doi.org/10.1111/1346-8138.15119DOI Listing
December 2019

Follicular occlusion disorders in Down syndrome patients.

Pediatr Dermatol 2020 Jan 18;37(1):219-221. Epub 2019 Oct 18.

Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.

Disorders involving follicular occlusion, such as hidradenitis suppurativa, folliculitis, acneiform eruptions, and pilonidal cysts, have shown an increased prevalence in the Down syndrome (DS) population, but there are limited published data examining this association. We conducted a retrospective chart review of 243 DS patients presenting to a pediatric dermatology clinic to further examine the prevalence of disorders of follicular occlusion in DS patients. Our study showed high rates of disorders of follicular occlusion in DS patients, with prevalent disorders including folliculitis (21. Read More

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http://dx.doi.org/10.1111/pde.14012DOI Listing
January 2020
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Acne Vulgaris: Diagnosis and Treatment.

Am Fam Physician 2019 10;100(8):475-484

Louisiana State University Health Sciences Center-University Hospital and Clinics, Lafayette, LA, USA.

Acne vulgaris is the most prevalent chronic skin disease in the United States, affecting nearly 50 million people per year, mostly adolescents and young adults. Potential sequelae of acne, such as scarring, dyspigmentation, and low self-esteem, may result in significant morbidity. Typical acne lesions involve the pilosebaceous follicles and the interrelated processes of sebum production, Cutibacterium acnes (previously called Propionibacterium acnes) colonization, and inflammation. Read More

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October 2019
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Difficulties in emotion regulation and quality of life in patients with acne.

Qual Life Res 2020 Feb 11;29(2):431-438. Epub 2019 Oct 11.

Dermatology Department, Bozok University School of Medicine, Yozgat, Turkey.

Background: The psychological factors associated with the impairment of the quality of life (QoL) in acne vulgaris have not been fully elucidated, yet. The aim of the present study was to evaluate the performance of the difficulties in emotion regulation (DER) in predicting the QoL of patients with acne vulgaris and to examine the relationship between acne vulgaris and common psychopathologies, such as anxiety and depression.

Methods: A total of 141 patients were administered the difficulties in emotion regulation scale (DERS-Brief Form) (DERS-16), Hospital Anxiety and Depression Scale (HADS), and Acne Quality of Life (AQOL) Scale, while the control group including 102 participants was administered all scales other than the AQOL. Read More

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http://dx.doi.org/10.1007/s11136-019-02318-2DOI Listing
February 2020
2 Reads