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    Psychosocial impact of acne and postinflammatory hyperpigmentation.
    An Bras Dermatol 2017 Jul-Aug;92(4):505-509
    Department of Psychiatry and Behavioral Sciences; University of Miami Miller School of Medicine - Miami (FL), USA.
    Background:: Acne is one of the most common skin diseases. It has significant effect on self-image and negative impact on quality of life. Postinflammatory hyperpigmentation is an acquired hypermelanosis that occurs after a skin injury or cutaneous inflammation. Read More

    Dietary Supplements, Isotretinoin, and Liver Toxicity in Adolescents: A Retrospective Case Series.
    Pediatrics 2017 Oct 1;140(4). Epub 2017 Sep 1.
    University of California, San Diego/Rady Children's Hospital, San Diego, California.
    Isotretinoin is the most effective acne therapy available, but has the potential for a number of adverse side effects, including transaminitis. The iPLEDGE isotretinoin program recommends avoiding some herbals and supplements due to potential side effects. However, little is known about the effects of protein supplements on the liver, particularly in patients taking isotretinoin. Read More

    Chronic cutaneous lupus erythematosus presenting as atypical acneiform and comedonal plaque: case report and literature review.
    Lupus 2017 Jan 1:961203317726377. Epub 2017 Jan 1.
    Hospital do Servidor Público Municipal de São Paulo (HSPM), São Paulo, Brazil.
    Introduction Chronic cutaneous lupus erythematosus (CCLE) usually presents as characteristic erythematous patches and infiltrated coin-shaped plaques. However, there are some atypical clinical variants that may mimic other dermatological conditions. Haroon et al. Read More


    Treatment of Facial Acne Scarring With Fractional Carbon Dioxide Laser in Asians, a Retrospective Analysis of Efficacy and Complications.
    Dermatol Surg 2017 Sep;43(9):1137-1143
    *All authors are affiliated with the National Skin Centre, Singapore.
    Background: Fractional carbon dioxide (CO2) laser resurfacing unites the idea of fractional photothermolysis with an ablative 10,600-nm wavelength. This technology permits effective treatment of acne scarring, with shorter recovery and a decreased side effect profile as compared to traditional CO2 laser resurfacing.

    Objective: The aims of this study were to study the efficacy and safety of fractional CO2 laser for acne scars in Asian patients. Read More

    Trends in prescribing behavior of systemic agents used in the treatment of acne among dermatologists and nondermatologists: A retrospective analysis, 2004-2013.
    J Am Acad Dermatol 2017 Sep 1;77(3):456-463.e4. Epub 2017 Jul 1.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
    Background: Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns.

    Objective: To characterize changes in prescribing behavior for systemic agents in the treatment of acne in the United States between 2004 and 2013.

    Methods: We conducted a retrospective analysis using the OptumInsight Clinformatics DataMart (Optum, Eden Prairie, MN). Read More

    Psychiatric disorders, acne and systemic retinoids: comparison of risks.
    Expert Opin Drug Saf 2017 Sep 12;16(9):989-995. Epub 2017 Jul 12.
    c INSERM UMR 1246 , University of Nantes and Tours , Nantes et Tours , France.
    Background: The link between isotretinoin, treatment of a severe form of acne, and psychiatric disorders remains controversial, as acne itself could explain the occurrence of psychiatric disorders. This study aims at assessing the disproportionality of psychiatric adverse events reported with isotretinoin in the French National PharmacoVigilance Database, compared with other systemic acne treatments and systemic retinoids.

    Materials And Methods: Data were extracted from the French National PharmacoVigilance Database for systemic acne treatments, systemic retinoids and drugs used as comparators. Read More

    Prescription patterns and costs of acne/rosacea medications in Medicare patients vary by prescriber specialty.
    J Am Acad Dermatol 2017 Sep 23;77(3):448-455.e2. Epub 2017 Jun 23.
    Department of Internal Medicine, Division of Dermatology, The Ohio State University Wexner Medical Center, Columbus, Ohio. Electronic address:
    Background: Prescription patterns for acne/rosacea medications have not been described in the Medicare population, and comparisons across specialties are lacking.

    Objective: To describe the medications used for treating acne/rosacea in the Medicare population and evaluate differences in costs between specialties.

    Methods: A cross-sectional study was performed of the 2008 and 2010 Centers for Medicare and Medicaid Services Prescription Drug Profiles, which contains 100% of Medicare part D claims. Read More

    Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris.
    J Invest Dermatol 2017 Jul;137(7):1405-1408
    Department of Dermatology, Environmental Medicine, Health Theory, Faculty of Human Sciences, University of Osnabrück, Osnabrück, Germany. Electronic address:
    Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Read More

    Antibiotic Resistance in Acne Treatment.
    JAMA Dermatol 2017 Aug;153(8):810-811
    Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles.
    Clinical Question: What is the evidence for antibiotic resistance in acne, and how does resistance affect treatment?

    Bottom Line: Use of topical and systemic antibiotics for acne is associated with formation of resistance in Propionibacterium acnes and other bacteria, with clinical consequences. Guidelines recommend resistance reduction strategies including avoidance of antibiotic monotherapy, combination treatment with topical modalities, and limiting the duration of oral antibiotic use. Read More

    Anti-acne drugs in phase 1 and 2 clinical trials.
    Expert Opin Investig Drugs 2017 Jul 19;26(7):813-823. Epub 2017 Jun 19.
    c Department of Venerology and Dermatology , Otto von Guericke University Magdeburg , Magdeburg , Germany.
    Introduction: Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue. Areas covered: A search for phase 1 and 2 acne treatment trials in the US National Institutes of Health database of clinical trials and the European Medicines Agency database with the key words 'acne' and 'treatment' was carried out, on 6 January 2017. Read More

    Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial.
    BMC Complement Altern Med 2017 Jun 17;17(1):318. Epub 2017 Jun 17.
    Department of Ophthalmology & Otolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
    Background: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Read More


    Evidence-based recommendations for the management of acne fulminans and its variants.
    J Am Acad Dermatol 2017 Jul;77(1):109-117
    University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
    Background: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. Read More

    ECTOPIC CUSHING SYNDROME: A 10-YEAR EXPERIENCE FROM A TERTIARY CARE CENTER IN SOUTHERN INDIA.
    Endocr Pract 2017 Aug 14;23(8):907-914. Epub 2017 Jun 14.
    Objective: Ectopic adrenocorticotropic hormone (ACTH) secretion is a less common cause of Cushing syndrome and is seen in 5 to 10% of cases with endogenous hypercortisolemia. We hereby describe our experience of patients with ectopic ACTH syndrome, who have been managed over the past 10 years at a tertiary care center in Southern India.

    Methods: The inpatient and outpatient records of patients from 2006 to 2015 were retrospectively reviewed. Read More

    Differences in Dietary Glycemic Load and Hormones in New York City Adults with No and Moderate/Severe Acne.
    J Acad Nutr Diet 2017 Sep 9;117(9):1375-1383. Epub 2017 Jun 9.
    Background: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis.

    Objective: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. Read More

    Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
    J Cosmet Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, 'Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    Refining the ideas of "ethnic" skin.
    An Bras Dermatol 2017 Mar-Apr;92(2):221-225
    Department of Dermatology, University of Buenos Aires - Buenos Aires, Argentina.
    Skin disease occur worldwide, affecting people of all nationalities and all skin types. These diseases may have a genetic component and may manifest differently in specific population groups; however, there has been little study on this aspect. If population-based differences exist, it is reasonable to assume that understanding these differences may optimize treatment. Read More

    Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.
    An Bras Dermatol 2017 Mar-Apr;92(2):212-216
    Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah - Sabah, Malaysia.
    Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Read More

    Effects of isotretinoin on the olfactory function in patients with acne.
    An Bras Dermatol 2017 Mar-Apr;92(2):191-195
    Department of Dermatology and Venereology - Erciyes University Faculty of Medicine - Kayseri, Turkey.
    Background:: Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice.

    Objective:: This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy. Read More

    Evolution of some indicators of systemic immunity in patients with acne while using laser therapy.
    Wiad Lek 2017;70(2):196-199
    DANYLO HALYTSKY LVIV NATIONAL MEDICAL UNIVERSITY, LVIV, UKRAINE.
    Introduction: One of the important problems in modern dermatology is to improve treatment efficiency of acne being a common cause for cicatricial skin changes, loss of performance capability and social activity and negatively affects the psycho-emotional state of patients and their quality of life. The topicality of the disease is due to the high degree of its proliferation, chronic and recurrent course, and resistance to existing therapies. Reducing the effectiveness of skin diseases treatment, including that of acne, at present, is associated with developing resistance to drugs, which causes the use of non-drug methods in dermatology nowadays, including low-intensity laser therapy. Read More

    Improvement of Atrophic Acne Scars in Skin of Color Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study.
    J Drugs Dermatol 2017 Apr;16(4):322-326

    BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.

    OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color. Read More


    Clindamycin phosphate-tretinoin combination gel revisited: status report on a specific formulation used for acne treatment.
    Cutis 2017 Mar;99(3):179-183
    JDR Dermatology Research LLC/Thomas Dermatology, Las Vegas and Henderson, Nevada, and Touro University Nevada, Henderson, USA.
    Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Read More

    Oral contraceptives for acne treatment: US Dermatologists' knowledge, comfort, and prescribing practices.
    Cutis 2017 Mar;99(3):195-201
    Permanente Medical Group, Pleasanton, California, USA.
    The use of oral contraceptive pills (OCPs), which can be an effective treatment of acne in women, is poorly understood among many dermatologists. In this study, we surveyed 116 US dermatologists about their knowledge, comfort, and prescribing practices pertaining to the use of OCPs. The majority of respondents had previously prescribed OCPs and believed they were an effective treatment of acne in women. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 05;37(suppl_1):S45-S58
    Dermatologist in private practice in Miami, FL, USA.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    AbobotulinumtoxinA: A 25-Year History.
    Aesthet Surg J 2017 05;37(suppl_1):S4-S11
    Director and Founder of Toxin Science Limited, Wrexham, UK.
    During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd. Read More

    Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats.
    Tissue Cell 2017 Apr 9;49(2 Pt B):203-208. Epub 2017 Mar 9.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. Read More

    Multiple miliary osteoma cutis of the face associated with Albright hereditary osteodystrophy in the setting of acne vulgaris: a case report.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Internal Medicine, University of Central Florida College of Medicine, Orlando Florida.
    Osteoma cutis is a condition characterized by theformation of bone within the skin. Such aberrantossification of the skin and subcutaneous tissue isconsidered primary when it arises in the absence ofunderlying tissue damage or a preceding cutaneouslesion. Conversely, secondary osteoma cutis occurswhen skin ossification is the result of a pre-existingskin lesion, trauma, or inflammatory process [1,2]. Read More

    Bromoderma in an infant.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):17-19
    Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA) - Porto Alegre (RS), Brazil.
    Bromoderma is a cutaneous eruption caused by the absorption of bromide. Clinical manifestations include acneiform and vegetative lesions. We report the case of an infant with bromoderma caused by the use of syrup for abdominal colic containing calcium bromide. Read More

    Isotretinoin treatment for acne and risk of depression: A systematic review and meta-analysis.
    J Am Acad Dermatol 2017 Jun 11;76(6):1068-1076.e9. Epub 2017 Mar 11.
    Department of Psychiatry, Cardinal Tien Hospital, New Taipei City, Taiwan; Department of Public Health and Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
    Background: The relationship between isotretinoin treatment for acne and depression is controversial. Quantitative analysis has not yet been conducted.

    Objective: To conduct a meta-analysis, evidence-based examination of the relationship between isotretinoin and depression. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Inhibition of Sebum Production with the Acetyl Coenzyme A Carboxylase Inhibitor Olumacostat Glasaretil.
    J Invest Dermatol 2017 Jul 1;137(7):1415-1423. Epub 2017 Mar 1.
    Dermira, Inc., Menlo Park, California, USA. Electronic address:
    Olumacostat glasaretil (OG) is a small molecule inhibitor of acetyl coenzyme A (CoA) carboxylase (ACC), the enzyme that controls the first rate-limiting step in fatty acid biosynthesis. Inhibition of ACC activity in the sebaceous glands is designed to substantially affect sebum production, because over 80% of human sebum components contain fatty acids. OG inhibits de novo lipid synthesis in primary and transformed human sebocytes. Read More

    Characteristics of premenstrual acne flare-up and benefits of a dermocosmetic treatment: a double-blind randomised trial.
    Eur J Dermatol 2017 Apr;27(2):144-149
    Dermatology department, Nantes University Hospital, 1 place A. Ricordeau, 44093 Nantes, France, CRCNA, Inserm U892, CNRS 6299, 9 quai Moncousu, 44093 Nantes Cedex 1, France.
    To date, facial acne flare-ups in adult women during the luteal phase of the menstrual cycle have been poorly investigated. To clinically characterize premenstrual acne flare-up in adult women and investigate the effect of a dermocosmetic treatment. This single-centre study included 32 young adult women with declared premenstrual acne flares and was composed of two phases: (1) an observational phase (two menstrual cycles) and (2) an interventional phase (one menstrual cycle) in a controlled, randomised, double-blind, intra-individual (half-face) setting in which a dermocosmetic (containing lipohydroxyacid, nicotinamide, and piroctone-olamine) and placebo were compared. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Jun;18(3):333-341
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Mothers' attitude to the use of a combined oral contraceptive pill by their daughters for menstrual disorders or contraception.
    Hong Kong Med J 2017 Apr 24;23(2):150-7. Epub 2017 Feb 24.
    Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
    Introduction: Mothers' attitude may affect use of combined oral contraceptive pills by their daughters. We explored Chinese mothers' knowledge of and attitudes towards the use of combined oral contraceptive pills by their daughters for menstrual disorders or contraception, and evaluate the factors affecting their attitude.

    Methods: This survey was conducted from October 2012 to March 2013, and recruited Chinese women who attended a gynaecology clinic or accompanied their daughter to a gynaecology clinic, and who had one or more daughters aged 10 to 18 years. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):415-423
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

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