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    1 OF 221

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Feb 28. Epub 2017 Feb 28.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Feb 7. Epub 2017 Feb 7.
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study.
    Arch Dermatol Res 2017 Apr 8;309(3):159-167. Epub 2017 Feb 8.
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. Read More

    Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
    Microbiol Immunol 2017 Jan;61(1):42-44
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
    The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. Read More

    Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds.
    Int J Mol Sci 2017 Jan 17;18(1). Epub 2017 Jan 17.
    Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania.
    The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i. Read More

    Multiple Activities of Punica granatum Linne against Acne Vulgaris.
    Int J Mol Sci 2017 Jan 12;18(1). Epub 2017 Jan 12.
    PhD Program for Clinical Drug Discovery of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. Read More

    Chemical pharmacotherapy options for managing adult acne.
    Expert Opin Pharmacother 2017 Feb 23;18(3):263-273. Epub 2017 Jan 23.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Read More

    Modern management of acne.
    Med J Aust 2017 Jan;206(1):41-45
    Royal North Shore Hospital, Sydney, NSW.
    Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects. Read More

    Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.
    J Am Acad Dermatol 2017 Jan 28;76(1):33-39. Epub 2016 Oct 28.
    Windsor Clinical Research Inc, Windsor, Ontario, Canada.
    Background: Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.

    Objectives: Safety and efficacy of OG 7. Read More

    Treatment of Acne Scars on Darker Skin Types Using a Noninsulated Smooth Motion, Electronically Controlled Radiofrequency Microneedles Treatment System.
    Dermatol Surg 2017 Jan;43 Suppl 1:S64-S69
    Department of Dermatology, Jubilee Mission Medical College, Thrissur, India and Pudukadan's Dermalaser Centre, Thrissur, India.
    Background: Noninvasive technologies for treating acne scars use radiofrequency (RF)-emitting microneedles for both mechanical disruption of fibrotic strands and heat-mediated collagen remodeling.

    Objective: Efficacy and safety evaluation of electronically controlled noninsulated RF microneedling system on acne scars in patients with dark skin.

    Methods: Nineteen patients, 24 to 51 years old, skin types III to V, with acne scars were enrolled in the study. Read More

    Fractional Erbium-Doped Yttrium Aluminum Garnet Laser Versus Microneedling in Treatment of Atrophic Acne Scars: A Randomized Split-Face Clinical Study.
    Dermatol Surg 2017 Jan;43 Suppl 1:S47-S56
    *National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt; †Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: Ablative fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser and microneedling have been popularized in recent years and their effectiveness and side effects individually reported. No previous study, however, has directly compared the efficacy and safety between the 2 different treatments.

    Objective: To compare the efficacy and safety of the ablative fractional Er:YAG laser and microneedling for the treatment of atrophic acne scars. Read More

    Dapsone 7.5% Gel: A Review in Acne Vulgaris.
    Am J Clin Dermatol 2017 Feb;18(1):139-145
    Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
    Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2017 Mar 21;7(1):133-141. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors.
    Pediatr Dermatol 2017 Jan 16;34(1):90-94. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children.

    Methods: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. Read More

    Cosmeceuticals in skin of color.
    Semin Cutan Med Surg 2016 Dec;35(4):233-237
    Baumann Cosmetic and Research Institute, Miami, Florida, USA.
    Patients with skin of color have similar skin care needs as lighter-skin patients. However, they are less likely to use sun protection on a daily basis, which leads to an increased risk of dyschromia, skin cancer, and other disorders. This article discusses the importance of a correct and consistent skin care regimen and the various cutaneous issues that should be considered when prescribing a skin care regimen for patients with darker skin types. Read More

    Combination therapy in skin of color including injectables, laser, and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):211-217
    Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California, USA.
    With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Read More

    The Critical and Multifunctional Roles of Antimicrobial Peptides in Dermatology.
    Dermatol Clin 2017 Jan;35(1):39-50
    Department of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:
    Antimicrobial peptides are central effector molecules in skin immunology. The functions of antimicrobial peptides in skin diseases include the ability to act as cytokines or growth factors, driving disorders such as psoriasis and rosacea, as well as their action as natural antibiotics to control bacteria that influence diseases such as atopic dermatitis and acne. Read More

    The Utility of Text Message Reminders for Acne Patients: A Pilot Study.
    Am J Clin Dermatol 2017 Feb;18(1):133-137
    Southern California Permanente Medical Group, Los Angeles, CA, USA.
    Background: Acne vulgaris is one of the three most common cutaneous disorders, affecting approximately 50 million people in the US and many more throughout the world.

    Objective: We designed a pilot program to explore how patients may interact with cell phone technology to supplement medical care beyond patient reminders that would encompass education, interaction, and data capturing.

    Methods: Twenty-four patients completed a 3-month study in which participants received daily text message reminders for the first 2 weeks of the study, then once weekly thereafter, to take their oral medication or apply topical therapy either once or twice daily. Read More

    Primary cicatricial alopecia: Other lymphocytic primary cicatricial alopecias and neutrophilic and mixed primary cicatricial alopecias.
    J Am Acad Dermatol 2016 Dec;75(6):1101-1117
    Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Dermatology, New York University, New York, New York.
    Primary cicatricial alopecias can be frustrating for both patients and physicians. Proper diagnosis guides more successful management of these challenging conditions. Part II will cover the remaining lymphocytic primary cicatricial alopecias, which include pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. Read More

    Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women.
    Mol Med Rep 2016 Dec 4;14(6):5501-5506. Epub 2016 Nov 4.
    Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
    Acne is a disorder of the pilosebaceous unit, common among adolescents, which may be extended to adulthood. The aim of this study was to assess the prevalence of hormonal disorders in women with acne resistance to conventional therapy. We included 72 women aged between 15 and 36 years (divided in two age groups) who presented to our clinic between May and October 2014, suffering from moderate and severe forms of papulopustular and nodulocystic acne. Read More

    A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes.
    Int J Mol Sci 2016 Nov 9;17(11). Epub 2016 Nov 9.
    Department of Dermatology, School of Medicine, University of California, San Diego, CA 92093, USA.
    Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes) in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. Read More

    Survivin as a Novel Biomarker in the Pathogenesis of Acne Vulgaris and Its Correlation to Insulin-Like Growth Factor-I.
    Dis Markers 2016 10;2016:7040312. Epub 2016 Oct 10.
    Department of Dermatology, Faculty of Medicine, Sohag University, P.O. Box 82524, Sohag, Egypt.
    Survivin, a member of the inhibitor of apoptosis protein family, has an important role in cell cycle regulation. Insulin-like growth factor-I (IGF-I) is a polypeptide hormone with wide range of biologic effects including stimulation of lipogenesis in sebaceous glands. Their overexpression in some fibrotic disorders suggests a possible implication of both IGF-I and survivin in the pathogenesis of acne and/or acne scars. Read More

    Assessment of demodex presence in acne-like rash associated with cetuximab.
    Cutan Ocul Toxicol 2016 Nov 16:1-4. Epub 2016 Nov 16.
    b Medical Oncology Department, School of Medicine, Karadeniz Technical University , Trabzon , Turkey , and.
    Context: Cetuximab is an epidermal growth factor receptor inhibitor. It is frequently used in the treatment of solid tumors. However, it has a high potential to cause acne-like rash. Read More

    In vitro antimicrobial susceptibility patterns of Propionibacterium acnes isolated from patients with acne vulgaris.
    J Infect Dev Ctries 2016 Oct 31;10(10):1140-1145. Epub 2016 Oct 31.
    Vardhman Mahavir Medical College and Safdarjang Hospital, New Delhi, India.
    Introduction: Propionibacterium acnes has been implicated in the development of acne vulgaris. Rampant use of topical and systemic antibiotics for acne vulgaris has led to resistance due to selective pressure. This study aimed to determine antibiotic resistance of P. Read More

    Emergence of fluoroquinolone-resistant Propionibacterium acnes caused by amino acid substitutions of DNA gyrase but not DNA topoisomerase IV.
    Anaerobe 2016 Dec 26;42:166-171. Epub 2016 Oct 26.
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. Electronic address:
    With the aim of elucidating the mechanisms of fluoroquinolones resistance in Propionibacterium acnes, we determined the susceptibility of fluoroquinolones in 211 isolates from patients with acne vulgaris. We identified five isolates (2.4%) with reduced susceptibility to nadifloxacin (minimum inhibitory concentration ≥ 4 μg/ml). Read More

    Sox9 facilitates proliferation, differentiation and lipogenesis in primary cultured human sebocytes.
    J Dermatol Sci 2017 Jan 13;85(1):44-50. Epub 2016 Oct 13.
    Department of Dermatology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China. Electronic address:
    Background: The transcription factor Sox9 is pivotal in the morphogenesis of hair follicles, but its role in sebocytes is poorly understood.

    Objective: We investigated the effect of Sox9 on human sebocyte proliferation, differentiation and lipogenesis.

    Methods: Sox9 expression was detected by immunohistochemistry in normal skin and acne lesion. Read More

    Epidemiology of post-adolescence acne and adolescence acne in Singapore: a 10-year retrospective and comparative study.
    J Eur Acad Dermatol Venereol 2016 Oct 12;30(10):1790-1793. Epub 2016 Jul 12.
    The National Skin Centre (NSC), 1 Mandalay Rd, 308205, Singapore.
    Introduction: Acne vulgaris commonly affects adolescents. But recent reports suggest a rising prevalence of post-adolescence acne. While there are few reports on post-adolescence acne, there are even fewer reports comparing adolescence acne and post-adolescence. Read More

    Inflammatory facial acne during uncomplicated pregnancy and post-partum in adult women: a preliminary hospital-based prospective observational study of 35 cases from Taiwan.
    J Eur Acad Dermatol Venereol 2016 Oct 22;30(10):1787-1789. Epub 2016 Apr 22.
    IZZ Immunologie-Zentrum Zürich, Zurich, Switzerland.
    Background: Pregnancy is associated with significant changes in hormones and metabolism which can also exert impact on the skin.

    Objectives: The study was aimed to evaluate the facial acne severity during pregnancy and post-partum period and to identify risk factors for acne in pregnancy.

    Methods: A hospital-based prospective study on pregnant women at age ≥18 years was conducted during their routine maternal examination. Read More

    Side effects of retinoid therapy on the quality of vision.
    Acta Pharm 2016 Dec;66(4):471-478
    Retinoids are compounds chemically related to vitamin A, which are frequently used in dermatological practice (1). They are characterized by numerous mechanisms of action leading to normalization of keratinocyte proliferation and maturation. They have anti-seborrhoeic, immunomodulatory and anti-inflammatory effects (1, 2). Read More

    Safety and Pharmacokinetics of Once-Daily Dapsone Gel, 7.5% in Patients With Moderate Acne Vulgaris.
    J Drugs Dermatol 2016 Oct;15(10):1250-1259
    Background: Reducing the dosing frequency of topical acne treatments to once daily may improve adherence.

    Objective: Evaluate pharmacokinetics (PK), safety, and tolerability of 3 formulations of once-daily dapsone gel, 7.5% and of twice-daily dapsone gel, 5% over 28 days in patients with moderate acne vulgaris. Read More

    Therapeutic Synergy, Neutrality, and Antagonism: Combination Treatment in Dermatology.
    J Drugs Dermatol 2016 Oct;15(10):1203-1207
    Dermatologists frequently employ combination therapy to treat various diseases, but the evidence to support the use of such combinations is often lacking. Synergy is an appealing although somewhat ambiguous concept in medicine. Utilizing synergy allows clinicians to provide the most efficacious combination of treatments to patients, while potentially minimizing adverse effects and reducing the development of drug resistance. Read More

    Stratum Corneum Abnormalities and Disease-Affected Skin: Strategies for Successful Outcomes in Inflammatory Acne.
    J Drugs Dermatol 2016 Oct;15(10):1170-1173
    Stratum corneum (SC) abnormalities are associated with disease-affected skin conditions such as inflammatory acne. Current topical acne treatment options including benzoyl peroxide and retinoids can worsen the barrier dysfunctions by increasing transepidermal water loss, depleting SC vitamin E levels, and relatively decreasing SC thickness. However, strategies exist to employ these treatments in a more effective manner and lessen barrier function disruption including use of less irritating vehicles or concomitant application of moisturizers. Read More

    Effect of Dermabrasion and ReCell(®) on Large Superficial Facial Scars Caused by Burn, Trauma and Acnes(△).
    Chin Med Sci J 2016 Sep;31(3):173-179
    Department of Dermatology, Peking Xiang-Yun Dermatological Hospital, Beijing 100068, China.
    Objective To explore the effects of dermabrasion combined with ReCell(®) on large superficial facial scars caused by burn, trauma and acnes.Methods Nineteen patients with large superficial facial scars were treated by the same surgeon with dermabrasion combined with ReCell(®). According to the etiology, patients were classified into post-burning group (n=5), post-traumatic group (n=7) and post-acne group (n=7). Read More

    Single Session Treatment of Rolling Acne Scars Using Tumescent Anesthesia, 20% Trichloracetic Acid Extensive Subcision, and Fractional CO2 Laser.
    Dermatol Surg 2017 Jan;43 Suppl 1:S70-S74
    *Gateway Aesthetic Institute and Laser Center, Salt Lake City, Utah; †Goldman, Butterwick, Fitzpatrick, Groff & Fabi, Cosmetic Laser Dermatology, San Diego, California.
    Background: Successful treatment of acne scars is challenging. Many modalities have been used with marginal success.

    Objective: The authors describe a combination of a superficial chemical peel, subcision, and fractional carbon dioxide (CO2) laser resurfacing in a single-treatment session as a novel treatment approach for rolling acne scars. Read More

    Impact of acne vulgaris on quality of life and self-esteem.
    Cutis 2016 Aug;98(2):121-4
    Department of Psychiatry, Oxford Medical College, Hospital & Research Center, Bangalore, India.
    The psychological impact of acne is determined by various factors including age, sex, personality, grade of disease, scarring, and environmental and ethnic background. Apart from managing the clinical manifestations of acne, clinicians also have to deal with the psychological aspects of the disease by assessing patients' quality of life (QOL) and self-esteem. These measures will aid in better management of acne patients. Read More

    Significant reduction of inflammation and sebaceous glands size in acne vulgaris lesions after intense pulsed light treatment.
    Dermatol Ther 2017 Jan 9;30(1). Epub 2016 Sep 9.
    Dermatology Department, Samalout Hospital, Minia, Egypt.
    Intense pulsed light (IPL) has been used for years in treatment of acne vulgaris. However, quantitative evaluation of histopathological changes after its use as a sole therapy was poorly investigated. Accordingly, this study aims to objectively evaluate inflammatory infiltrate and sebaceous glands in acne vulgaris after IPL. Read More

    Are topical retinoids teratogenic?
    G Ital Dermatol Venereol 2016 Dec 6;151(6):700-705. Epub 2016 Sep 6.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy -
    Retinoic acid is a physiological compound of human blood. Blood levels range from 1000 to 7000 pg/mL (usually 1500-5000 pg/mL). Results of studies on absorption of topical retinoic acid in laboratory animals, although rather conflicting, demonstrate that it induces plasma concentrations which are well below concentrations caused by non-teratogenic oral doses. Read More

    Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne.
    Benef Microbes 2016 Nov 6;7(5):625-630. Epub 2016 Sep 6.
    2 2E Science, Via Monte Grappa, 13, 27038 Robbio (PV), Italy.
    Systemic supplementation with probiotics is increasingly being explored as a potential treatment strategy for skin disorders. Because both the gut-skin axis and dysregulation of insulin signalling have been implicated in the pathogenesis of adult acne, we designed the current study to evaluate the effect of supplementation with the probiotic strain Lactobacillus rhamnosus SP1 (LSP1) on skin expression of genes involved in insulin signalling and acne improvement in adult subjects. A pilot, randomised, double-blinded, placebo-controlled study was conducted with 20 adult subjects (14 females and 6 males; mean age: 33. Read More

    Rosacea fulminans or acute rosacea? Report of 5 cases and review of the literature.
    G Ital Dermatol Venereol 2016 Oct;151(5):553-7
    Section of Dermatology, Department of Medical Sciences, S. Anna Hospital, Ferrara University Hospitals, Ferrara, Italy -
    Rosacea fulminans, previously called pyoderma faciale, is an inflammatory disease considered a dramatic form of rosacea rather than of acne. Typical features are: exclusive facial involvement of young women, sudden onset of large nodules without other signs of acne, remission without scarring or with minimal scars, no recurrences or systemic symptoms. Oral isotretinoin associated with a short course of systemic and topical corticosteroids represent the recommended treatment. Read More

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