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    Acneiform eruptions caused by vitamin B12: A report of five cases and review of the literature.
    J Cosmet Dermatol 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, 'Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
    We describe five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively. The eruption appeared from 1 week to 5 months after the beginning of the therapy with i.m. Read More

    Misuse of Topical Corticosteroids over Face: A Clinical Study.
    Indian Dermatol Online J 2017 May-Jun;8(3):186-191
    Department of Dermatology, Swami Dayanand Hospital, New Delhi, India.
    Introduction: Topical corticosteroids (TCS) have been widely used in various dermatological diseases. However, because of inadvertent use, TCS misuse has become a common problem faced by dermatologists in various parts of the world. Prolonged use over the face can cause various side effects such as steroid rosacea, acneiform eruptions, and hypertrichosis. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 May;37(suppl_1):S45-S58
    Dr Schlessinger is a dermatologist and cosmetic surgeon in private practice in Omaha, NE. Dr Gilbert is a dermatologist in private practice in Brooklyn, NY. Dr Cohen is a dermatologist in private practice in Greenwood Village, CO. Dr Kaufman is dermatologist in private practice in Miami, FL.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    AbobotulinumtoxinA: A 25-Year History.
    Aesthet Surg J 2017 May;37(suppl_1):S4-S11
    Dr Monheit is a Dermatologist, Departments of Dermatology and Ophthalmology, University of Alabama at Birmingham, Birmingham, AL. Dr Pickett is Director and Founder of Toxin Science Limited, Wrexham, UK; and an Adjunct Professor at the Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA.
    During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd. Read More

    Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats.
    Tissue Cell 2017 Apr 9;49(2 Pt B):203-208. Epub 2017 Mar 9.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Jun;18(3):333-341
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Effects of air pollution on the skin: A review.
    Indian J Dermatol Venereol Leprol 2017 Jul-Aug;83(4):415-423
    Department of Skin and STD, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India.
    The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study.
    Arch Dermatol Res 2017 Apr 8;309(3):159-167. Epub 2017 Feb 8.
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Apr;18(2):169-191
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria.
    Phytother Res 2017 Mar 26;31(3):410-417. Epub 2017 Jan 26.
    School of Pharmacy, De Montfort University, Leicester, UK.
    Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Read More

    Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
    Microbiol Immunol 2017 Jan;61(1):42-44
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
    The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. Read More

    Development and Sequential Analysis of a New Multi-Agent, Anti-Acne Formulation Based on Plant-Derived Antimicrobial and Anti-Inflammatory Compounds.
    Int J Mol Sci 2017 Jan 17;18(1). Epub 2017 Jan 17.
    Department of Botany-Microbiology, Research Institute of the University of Bucharest-ICUB, University of Bucharest, Faculty of Biology, SplaiulIndependenţei 91-95 Sector 5, 76201 Bucharest, Romania.
    The antibacterial and anti-inflammatory potential of natural, plant-derived compounds has been reported in many studies. Emerging evidence indicates that plant-derived essential oils and/or their major compounds may represent a plausible alternative treatment for acne, a prevalent skin disorder in both adolescent and adult populations. Therefore, the purpose of this study was to develop and subsequently analyze the antimicrobial activity of a new multi-agent, synergic formulation based on plant-derived antimicrobial compounds (i. Read More

    Results of a Phase 2, Randomized,Vehicle-Controlled Study Evaluating the Efficacy,Tolerability, and Safety of Daily or Twice Daily SB204 for the Treatment of Acne Vulgaris.
    J Drugs Dermatol 2016 Dec;15(12):1496-15027
    Objective: This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris.

    Methods: Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12). Read More

    Combination Therapy for Acne Scarring: Personal Experience and Clinical Suggestions.
    J Drugs Dermatol 2016 Nov;15(11):1413-1419
    Acne is one of the most prevalent skin conditions seen by dermatologists. The cosmetic sequelae of severe acne, including scarring and pigmentation, have a profound psychological impact on those in icted. Topical (eg, retinoids, antibiotics, dapsone, hydroxyacids) and oral treatments (eg, antibiotics and/or spironolactone) are often bene cial to control acne or in the instance of oral isotretinoin use, rid the acne permanently; however, these treatments have very little affect on the ultimate cosmetic outcome of the acne scarring and skin texture that results. Read More

    Acne Treatment With 3-Step Broadband Light Protocol.
    J Drugs Dermatol 2016 Nov;15(11):1382-1388
    Background And Objective: A new 3-step protocol using broadband light allows patients with moderate to severe in ammatory acne to avoid potential side effects of systemic acne treatments and the risks and uncertainties associated with laser and light treatments to date. The protocol also addresses acne scarring and, with appropriate modi cations, all skin types.

    Methods: The protocol consists of 6 to 8 treatments performed with a single device that allows the user to select wavelength, spot size, uence, and pulse duration. Read More

    Integrated Cooling-Vacuum-Assisted Non-Fractional 1540 nm Erbium:Glass Laser is Effective in Treating Acne Scars.
    J Drugs Dermatol 2016 Nov;15(11):1359-1363
    Introduction: Acne scars are a common result of in ammatory acne, affecting many patients worldwide. Among which, atrophic scars are the most prevalent form, presenting as dermal depressions caused by inflammatory degeneration of dermal collagen. Mid-infrared laser skin interaction is characterized by its modest absorption in water and nite penetration to the mid-dermis. Read More

    Comparison of the Cutaneous Thermal Signatures Over Twenty-Four Hours With a Picosecond Alexandrite Laser Using a Flat or Fractional Optic.
    J Drugs Dermatol 2016 Nov;15(11):1347-1352
    Introduction: This study explored immediate heat signatures with different passing techniques and the delayed thermal data points with the picosecond Alexandrite laser with the 6mm at and fractional optic during and after treatment. We sought to clarify the im- mediate effects of heating and understand the thermal and short term clinical difference when using these optics.

    Results: There were no immediate differences or a signi cant temperature rise with different passing techniques using the at or the fractional optic. Read More

    Spotlight on the Use of Nitric Oxide in Dermatology: What Is It? What Does It Do? Can It Become an Important Addition to the Therapeutic Armamentarium for Skin Disease?
    J Drugs Dermatol 2017 Jan;16(1):s4-s10
    Nitric oxide (NO) is a diatomic gas that is synthesized within and released by multiple host cell types functioning to provide a variety of physiologic and homeostatic effects. Nitric oxide exhibits a variety of effects that relate significantly with outcomes that can provide therapeutic benefit if properly formulated and released. These include anti-inflammatory, immunomodulatory, antimicrobial, vasodilatory properties, and effects that are beneficial to wound healing. Read More

    Multiple Activities of Punica granatum Linne against Acne Vulgaris.
    Int J Mol Sci 2017 Jan 12;18(1). Epub 2017 Jan 12.
    PhD Program for Clinical Drug Discovery of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. Read More

    Chemical pharmacotherapy options for managing adult acne.
    Expert Opin Pharmacother 2017 Feb 23;18(3):263-273. Epub 2017 Jan 23.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Read More

    Modern management of acne.
    Med J Aust 2017 Jan;206(1):41-45
    Royal North Shore Hospital, Sydney, NSW.
    Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production; altered keratinisation; bacterial colonisation of hair follicles on the face, neck, chest and back by Propionibacterium acnes; and an inflammatory response in the skin. The exact way these processes interact and the order in which they occur in the pathogenesis of acne are still unclear. Scarring that occurs from acne, particularly severe acne, can persist a lifetime and have long lasting psychosocial effects. Read More

    The Use of Cosmeceuticals in Acne: Help or Hoax?
    Am J Clin Dermatol 2017 Apr;18(2):159-163
    Department of Dermatology, Penn State/Hershey Medical Center, HU14, 500 University Drive, Hershey, PA, 17022, USA.
    The use of cosmeceuticals by patients with acne is common; however, their role is unclear and confusing, with many asking, "Do they really help acne?" Cosmeceuticals are intermediate products between prescription medications and cosmetics, available to consumers over the counter. These products are popular and may be used without the direct supervision of a dermatologist, creating a practice gap in educating patients. Herein, a variety of cosmeceuticals are discussed, including retinoids, niacinamide, and glycolic acid. Read More

    Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.
    J Am Acad Dermatol 2017 Jan 28;76(1):33-39. Epub 2016 Oct 28.
    Windsor Clinical Research Inc, Windsor, Ontario, Canada.
    Background: Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.

    Objectives: Safety and efficacy of OG 7. Read More

    Treatment of Acne Scars on Darker Skin Types Using a Noninsulated Smooth Motion, Electronically Controlled Radiofrequency Microneedles Treatment System.
    Dermatol Surg 2017 Jan;43 Suppl 1:S64-S69
    Department of Dermatology, Jubilee Mission Medical College, Thrissur, India and Pudukadan's Dermalaser Centre, Thrissur, India.
    Background: Noninvasive technologies for treating acne scars use radiofrequency (RF)-emitting microneedles for both mechanical disruption of fibrotic strands and heat-mediated collagen remodeling.

    Objective: Efficacy and safety evaluation of electronically controlled noninsulated RF microneedling system on acne scars in patients with dark skin.

    Methods: Nineteen patients, 24 to 51 years old, skin types III to V, with acne scars were enrolled in the study. Read More

    Fractional Erbium-Doped Yttrium Aluminum Garnet Laser Versus Microneedling in Treatment of Atrophic Acne Scars: A Randomized Split-Face Clinical Study.
    Dermatol Surg 2017 Jan;43 Suppl 1:S47-S56
    *National Institute of Laser Enhanced Sciences, Cairo University, Cairo, Egypt; †Department of Dermatology, Faculty of Medicine, Cairo University, Cairo, Egypt.
    Background: Ablative fractional erbium-doped yttrium aluminum garnet (Er:YAG) laser and microneedling have been popularized in recent years and their effectiveness and side effects individually reported. No previous study, however, has directly compared the efficacy and safety between the 2 different treatments.

    Objective: To compare the efficacy and safety of the ablative fractional Er:YAG laser and microneedling for the treatment of atrophic acne scars. Read More

    Laser Safety in Isotretinoin Use: A Survey of Expert Opinion and Practice.
    Dermatol Surg 2017 Mar;43(3):357-363
    *SkinCare Physicians, Chestnut Hill, Massachusetts; †Feinberg School of Medicine, Department of Dermatology, Northwestern University, Chicago, Illinois.
    Background: Reports of poor wound healing in the setting of isotretinoin treatment have created a conservative standard of care in which laser and phototherapy treatment of patients receiving isotretinoin is relatively contraindicated.

    Objective: A survey of 220 nationally recognized experts in cutaneous laser surgery was conducted to evaluate physician experience and opinion pertaining to laser and light procedures in patients treated with isotretinoin, including perceived risk and actual complications.

    Results: There was a 42% response rate. Read More

    Dapsone 7.5% Gel: A Review in Acne Vulgaris.
    Am J Clin Dermatol 2017 Feb;18(1):139-145
    Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
    Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. Read More

    Cutaneous Side Effects and Transepidermal Water Loss To Gefitinib: A Study of 11 Patients.
    Dermatol Ther (Heidelb) 2017 Mar 21;7(1):133-141. Epub 2016 Dec 21.
    Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran-Dr. Hasan Sadikin General Hospital, Bandung, Indonesia.
    Introduction: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor.

    Methods: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016. Read More

    Cutaneous Reactions in Children Treated with the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase Inhibitor Trametinib for Neural Tumors.
    Pediatr Dermatol 2017 Jan 16;34(1):90-94. Epub 2016 Dec 16.
    Division of Pediatric Dermatology, Department of Dermatology, University of Minnesota, Minneapolis, Minnesota.
    Background: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children.

    Methods: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. Read More

    Acne: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):710-716. Epub 2016 Jul 9.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; Department of Pediatrics, University of Connecticut Health Science Center, Farmington, CT.
    Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endocrine or hormonal tests are indicated. We also discuss age-dependent treatment considerations, including appropriate oral antimicrobial regimens and the proper dosing of isotretinoin in young children versus teenagers and adults. Read More

    Nutrition and skin: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):698-709. Epub 2016 Jul 9.
    Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA.
    There has been a surge of new data regarding the pathophysiology of skin diseases. We are appreciating the sophisticated interplay among the skin, the immune system, and the environment. More elegant and highly specific medicines have been designed to target certain immune mediators of the adaptive immune system. Read More

    Ethnic skin: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):690-697. Epub 2016 Jul 12.
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL. Electronic address:
    There are numerous skin conditions that occur commonly in children with ethnic skin, including vitiligo, progressive macular hypomelanosis, pityriasis alba, acne keloidalis nuchae, pseudofolliculitis barbae, and keloids. Though these conditions occur in both children and adults, children may have different patterns of clinical presentation and response to therapy. In caring for such patients, important treatment considerations include side effects of systemic medications and tolerability of invasive procedures. Read More

    Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes.
    Anaerobe 2017 Feb 5;43:61-68. Epub 2016 Dec 5.
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. Electronic address:
    Virulence enzymes and biofilm a play crucial role in the pathogenesis of Propionibacterium acnes, a major causative agent of acne vulgaris. In the present study, the effects of rhodomyrtone, a pure compound identified from Rhodomyrtus tomentosa (Aiton) Hassk. leaves extract against enzyme production and biofilm formation production by 5 clinical isolates and a reference strain were evaluated. Read More

    Cosmeceuticals in skin of color.
    Semin Cutan Med Surg 2016 Dec;35(4):233-237
    Baumann Cosmetic and Research Institute, Miami, Florida, USA.
    Patients with skin of color have similar skin care needs as lighter-skin patients. However, they are less likely to use sun protection on a daily basis, which leads to an increased risk of dyschromia, skin cancer, and other disorders. This article discusses the importance of a correct and consistent skin care regimen and the various cutaneous issues that should be considered when prescribing a skin care regimen for patients with darker skin types. Read More

    Combination therapy in skin of color including injectables, laser, and light devices.
    Semin Cutan Med Surg 2016 Dec;35(4):211-217
    Goldman, Butterwick, Groff, Fabi & Wu, Cosmetic Laser Dermatology, San Diego, California, USA.
    With the rapid increase in patients seeking cosmetic treatments, the variation in responses of lightly pigmented skin versus darkly pigmented skin has become increasingly apparent. Despite extensive treatment options in patients with skin of color, there is a paucity of well-designed studies performed on this patient population. The lack of research is concerning, as it is well documented that patients with darker skin types are at an increased risk of adverse events when treated with many of the available modalities used in cosmetic procedures. Read More

    The Critical and Multifunctional Roles of Antimicrobial Peptides in Dermatology.
    Dermatol Clin 2017 Jan;35(1):39-50
    Department of Dermatology, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address:
    Antimicrobial peptides are central effector molecules in skin immunology. The functions of antimicrobial peptides in skin diseases include the ability to act as cytokines or growth factors, driving disorders such as psoriasis and rosacea, as well as their action as natural antibiotics to control bacteria that influence diseases such as atopic dermatitis and acne. Read More

    Case Study: An intraoperative finding of black bone disease in a podiatric surgery patient.
    Foot (Edinb) 2016 Dec 20;29:6-10. Epub 2016 Sep 20.
    Department of Podiatric Surgery, Homerton University Hospital NHS Foundation Trust, Homerton Row, London, E9 6SR, United Kingdom.
    Black bone disease has been recognised as a potential consequence of long-term treatment with tetracycline antibiotics. Largely documented affecting structures in the head and skull, there are few reported cases of black bone disease in the foot and ankle. The case of a 55 years old patient, who as a teenager, had undergone treatment with minocycline hydrochloride for chronic acne, and was found to have bone discolouration consistent with minocycline induced black bone disease (MIBBD) during the course of hallux valgus corrective surgery some 40 years later, is presented. Read More

    The Utility of Text Message Reminders for Acne Patients: A Pilot Study.
    Am J Clin Dermatol 2017 Feb;18(1):133-137
    Southern California Permanente Medical Group, Los Angeles, CA, USA.
    Background: Acne vulgaris is one of the three most common cutaneous disorders, affecting approximately 50 million people in the US and many more throughout the world.

    Objective: We designed a pilot program to explore how patients may interact with cell phone technology to supplement medical care beyond patient reminders that would encompass education, interaction, and data capturing.

    Methods: Twenty-four patients completed a 3-month study in which participants received daily text message reminders for the first 2 weeks of the study, then once weekly thereafter, to take their oral medication or apply topical therapy either once or twice daily. Read More

    Primary cicatricial alopecia: Other lymphocytic primary cicatricial alopecias and neutrophilic and mixed primary cicatricial alopecias.
    J Am Acad Dermatol 2016 Dec;75(6):1101-1117
    Department of Dermatology, University of British Columbia, Vancouver, British Columbia, Canada; Department of Dermatology, New York University, New York, New York.
    Primary cicatricial alopecias can be frustrating for both patients and physicians. Proper diagnosis guides more successful management of these challenging conditions. Part II will cover the remaining lymphocytic primary cicatricial alopecias, which include pseudopelade of Brocq, central centrifugal cicatricial alopecia, alopecia mucinosa, and keratosis follicularis spinulosa decalvans. Read More

    Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women.
    Mol Med Rep 2016 Dec 4;14(6):5501-5506. Epub 2016 Nov 4.
    Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
    Acne is a disorder of the pilosebaceous unit, common among adolescents, which may be extended to adulthood. The aim of this study was to assess the prevalence of hormonal disorders in women with acne resistance to conventional therapy. We included 72 women aged between 15 and 36 years (divided in two age groups) who presented to our clinic between May and October 2014, suffering from moderate and severe forms of papulopustular and nodulocystic acne. Read More

    A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes.
    Int J Mol Sci 2016 Nov 9;17(11). Epub 2016 Nov 9.
    Department of Dermatology, School of Medicine, University of California, San Diego, CA 92093, USA.
    Acne dysbiosis happens when there is a microbial imbalance of the over-growth of Propionibacterium acnes (P. acnes) in the acne microbiome. In our previous study, we demonstrated that Staphylococcus epidermidis (S. Read More

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