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    1 OF 234

    Clinical significance of neutrophil gelatinase-associated lipocalin and galectin-7 in tape-stripped stratum corneum of acne vulgaris.
    J Dermatol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Dermatology, Toho University Ohashi Medical Center, Tokyo, Japan.
    The usefulness of stratum corneum neutrophil gelatinase-associated lipocalin and stratum corneum galectin-7 as biomarkers of acne vulgaris was studied. A comparison of neutrophil gelatinase-associated lipocalin levels on the cheeks of patients with acne vulgaris at the start of the study and at the time of symptom improvement showed a significant decrease. On the other hand, the galectin-7 levels at the time of symptom improvement were significantly higher than those at the start of the study. Read More

    Evaluation the Efficacy of Trichloroacetic Acid (TCA) 33% in Treatment of Oral Retinoid-Induced Cheilitis Compared with Placebo (Vaseline): A Randomized Pilot study.
    J Dermatolog Treat 2018 Feb 21:1-16. Epub 2018 Feb 21.
    a Tehran University of medical sciences , Tehran , Iran.
    Background: Oral Isotretinoin (13-cis-retinoic acid)is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication.we designed this novel study to investigate the therapeutic effect of Trichloroacetic Acid(TCA) 33% as compared with placebo to treat cheilitis.

    Methods: In this pilot study, 90 acne vulgaris patients between 18 to 50 years, who refered dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015,with data analysis in 2016. Read More

    Efficacy, Safety, and Tolerability of Topical Dapsone Gel, 7.5% for Treatment of Acne Vulgaris by Fitzpatrick Skin Phototype.
    J Drugs Dermatol 2018 Feb;17(2):160-167
    Background: Acne vulgaris (acne) is prevalent in individuals with skin of color, often with more frequent sequelae than in patients with lighter skin color. It is important to determine if there are also differences in response to medications.

    Objective: This study evaluated the efficacy and tolerability of once-daily dapsone gel, 7. Read More

    Clinical evidence for washing and cleansers in acne vulgaris: A systematic review.
    J Dermatolog Treat 2018 Feb 20:1-21. Epub 2018 Feb 20.
    a The Ronald O. Perelman Department of Dermatology , NYU School of Medicine ; 240 E 38th St. , New York , NY 10016.
    Purpose: Washing and over-the-counter cleansers are common interventions in acne vulgaris (AV), but the clinical evidence for their benefit is poorly understood. This systematic review presents clinical studies of washing and cleanser efficacy in acne vulgaris to guide treatment recommendations of dermatologists.

    Materials And Methods: We surveyed English-language articles indexed in MEDLINE (1951-March 2017) and EMBASE (1974-March 2017). Read More

    Vitamin D levels in acne vulgaris patients treated with oral isotretinoin.
    J Cosmet Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qina, Egypt.
    Background/objectives: Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. Read More

    Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
    Exp Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany.
    Sebocytes, the major cell type in sebaceous glands (SGs), are differentiated epithelial cells that gradually accumulate lipids and eventually disrupt, releasing their content (sebum) in a secretory process known as holocrine secretion. Via the hair canal, sebum reaches the skin surface, where it has several known or postulated functions, including pheromonal, thermoregulatory, antimicrobial and antioxidant activities. Altered sebum secretion and/or structural SG changes have also been involved in the pathogenesis of skin diseases, such as acne vulgaris and some forms of alopecia. Read More

    Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Lincoln Memorial University-DeBusk College of Osteopathic Medicine.
    The purpose of this literature review is to evaluate the use of metformin as an adjunct therapy in the treatment of moderate-to-severe acne in those not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors conducted independent literature searches. Results were limited to clinical trials and randomized controlled trials. Read More

    The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis.
    J Eur Acad Dermatol Venereol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. Read More

    Formulation And In-Vitro And Ex-Vivo Evaluation Of Tretinoin Loaded Cubosomal Gel For Acne Treatment.
    Recent Pat Drug Deliv Formul 2018 Feb 13. Epub 2018 Feb 13.
    Smriti College of Pharmaceutical Education, Dewas Naka, Indore, Madhya Pradesh 452010 . India.
    Objective: The current work was attempted to formulate and evaluate the topical sustained release delivery systems potential of bicontinuous cubic monoglyceride -water phases - 'cubosomes' containing Tretinoin with an opinion to sustain the release of drug in the acne treatment.

    Methods: Tretinoin loaded cubosomes were prepared by bottom-up technique, by varying the concentration of lipid and surfactant and keeping the drug concentration constant, made a total of nine formulations of tretinoin as TCF. These preparations were evaluated for its surface charge, particle size, particle morphology, encapsulation efficiency, in-vivo and in-vitro release studies of gel enriched with cubosome dispersion. Read More

    A Qualitative Investigation of the Impact of Acne on Health-Related Quality of Life (HRQL): Development of a Conceptual Model.
    Dermatol Ther (Heidelb) 2018 Mar 12;8(1):85-99. Epub 2018 Feb 12.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Introduction: The negative impact of acne on aspects of health-related quality of life (HRQL) has been demonstrated in many quantitative studies; however, there has been relatively little qualitative research exploring the impact of acne and the use of topical treatment. The study aimed to explore the impact of moderate-severe acne on HRQL in adolescents and adults with inflammatory and non-inflammatory lesions and to develop a conceptual model to illustrate the impact. In addition, the study aimed to identify the attributes of topical acne treatments that are most important for patients. Read More

    Comparing the Efficacy of Low Dose and Conventional Dose of Oral Isotretinoin in Treatment of Moderate and Severe Acne Vulgaris.
    J Res Pharm Pract 2017 Oct-Dec;6(4):233-238
    Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.

    Methods: This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment groups: 0. Read More

    Efficacy of Intense-pulsed Light Therapy with Topical Benzoyl Peroxide 5% versus Benzoyl Peroxide 5% Alone in Mild-to-moderate Acne Vulgaris: A Randomized Controlled Trial.
    J Res Pharm Pract 2017 Oct-Dec;6(4):199-205
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients' social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) with and without concomitant intense-pulsed light (IPL) therapy in mild-to-moderate acne vulgaris. Read More

    Topical 5-aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: A spilit face, randomized, prospective study.
    Dermatoendocrinol 2017 13;9(1):e1375634. Epub 2017 Oct 13.
    Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
    5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been an effective method for treating acne vulgaris. Red light is the most widely used light source while Intense pulsed lights (IPL) is reported effective and well-tolerated. The purpose of this study was to evaluate the efficacy and adverse reactions of ALA-PDT with red light on acne compared with ALA-PDT with IPL. Read More

    Propionibacterium acnes-derived extracellular vesicles promote acne-like phenotypes in human epidermis.
    J Invest Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
    Acne vulgaris is an inflammatory disease occurring in the pilosebaceous unit and is the most common skin condition in young people. A gram-positive bacterium, Propionibacterium acnes (P. acnes), has been suspected to contribute to the development of acne. Read More

    A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing.
    Skin Pharmacol Physiol 2018 Feb 7;31(2):107-113. Epub 2018 Feb 7.
    Department of Dermatology, The General Hospital of Air Force, Beijing, China.
    Background/aims: There is increasing evidence that exposure to air pollutants, including particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. Read More

    Plasma exeresis for active acne vulgaris: Clinical and in vivo microscopic documentation of treatment efficacy by means of reflectance confocal microscopy.
    Skin Res Technol 2018 Feb 6. Epub 2018 Feb 6.
    Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

    Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life.
    Medicine (Baltimore) 2017 Dec;96(51):e9366
    Department of Dermatology.
    Background: Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL).

    Methods: Ninety-five patients with moderate to severe facial acne (Investigator Global Assessment [IGA] score 3-4) were randomly treated with PDT and minocycline (n = 48) or minocycline alone (n = 47). Read More

    Epidermal Growth Factor Attenuated the Expression of Inflammatory Cytokines in Human Epidermal Keratinocyte Exposed to.
    Ann Dermatol 2018 Feb 26;30(1):54-63. Epub 2017 Dec 26.
    Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Background: While the beneficial effects of topical epidermal growth factor (EGF) on wound healing have been repeatedly reported, there are few reports about the effects of EGF on inflammatory skin diseases including acne.

    Objective: To clarify the effects of EGF on acne, it was investigated whether recombinant human EGF (rhEGF) signalling can affect-induced cytokine expression in human epidermal keratinocytes.

    Methods: The cultured normal human epidermal keratinocytes (NHK) were co-treated withand rhEGF, and mRNA levels of interleukin (IL)-1α, IL-8 and tumor necrosis factor (TNF)-α; toll-like receptor 2 (TLR2); and nuclear factor kappa B (NF-κB) were determined. Read More

    Erythema-directed digital photography for the enhanced evaluation of topical treatments for acne vulgaris.
    Skin Res Technol 2018 Jan 31. Epub 2018 Jan 31.
    Dermatology Clinic, University of Catania, Catania, Italy.
    Background: Erythema-directed digital photography is a novel method for evaluating the efficacy and tolerability of topical acne treatments. Here, we describe three case reports in which erythema-directed digital photography was used to evaluate acne before and after up to 12 weeks of treatment with clindamycin 1%/tretinoin 0.025% (Clin-RA). Read More

    Case report: remarkable remission of SAPHO syndrome in response to Tripterygium wilfordii hook f treatment.
    Medicine (Baltimore) 2017 Nov;96(47):e8903
    Department of Traditional Chinese Medicine.
    Rationale: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an autoinflammatory disease with no standardized treatment. Tripterygium wilfordii hook f (TwHF) is a Chinese herb with immunosuppressive effects and has been used to treat some chronic inflammatory diseases. However, it has not been reported as a therapeutic option in SAPHO syndrome. Read More

    Management of comedonal acne vulgaris with fixed-combination topical therapy.
    J Cosmet Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Valeant Pharmaceuticals, Bridgewater, NJ, USA.
    Background: Acne vulgaris (acne) is the most common skin disease we see in dermatology practice. Clinically, it is characterized by a combination of open and closed comedones (formally referred to as noninflammatory lesions) and inflammatory papules and pustules. Comedonal acne is more typical in young adolescents, but can occur in combination with inflammatory papules and pustules at any time. Read More

    The influence of exposome on acne.
    J Eur Acad Dermatol Venereol 2018 Jan 29. Epub 2018 Jan 29.
    Laboratoires Vichy, Levallois Perret, France.
    Background: Acne vulgaris is one of the main reasons for dermatological consultations. Severity and response to treatment may be impacted by various external factors or exposome.

    Aim: To assess the impact of environmental factors on acne and to provide a comprehensive overview of the acne exposome. Read More

    A Review on the Cosmeceutical and External Applications of.
    J Trop Med 2017 22;2017:7092514. Epub 2017 Nov 22.
    Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, State of Palestine.
    It is estimated by the World Health Organization (WHO) that most of the world's population depends on herbal medicine for their health care.also known as black-caraway and as "Kalonji," is a well-known seed all over the world. It is one of the most common medicinal plants worldwide and contains many useful chemical constituents that we can find in its fixed oil, such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellimine, nigellicine, nigellidine, and alpha-hederin. Read More

    Light-emitting diodes in dermatology: A systematic review of randomized controlled trials.
    Lasers Surg Med 2018 Jan 22. Epub 2018 Jan 22.
    Department of Dermatology, Downstate Medical Center, State University of New York, Brooklyn, New York.
    Objective: In dermatology, patient and physician adoption of light-emitting diode (LED) medical technology continues to grow as research indicates that LEDs may be used to treat skin conditions. The goal of this systematic review is to critically analyze published randomized controlled trials (RCTs) and provide evidence-based recommendations on the therapeutic uses of LEDs in dermatology based on published efficacy and safety data.

    Methods: A systematic review of the published literature on the use of LED treatments for skin conditions was performed on September 13th 2017. Read More

    Acne Scarring-Pathogenesis, Evaluation, and Treatment Options.
    J Clin Aesthet Dermatol 2017 Sep 1;10(9):12-23. Epub 2017 Sep 1.
    Drs. Connolly, Vu, and Saedi are with the Department of Dermatology and Cutaneous Biology at Thomas Jefferson University Hospital in Philadelphia, Pennsylvania.
    Acne vulgaris is a ubiquitous problem affecting 80 percent of people ages 11 to 30 years, with many patients experiencing some degree of scarring. This review focuses on atrophic scars, the most common type of acne scar. We briefly address the cellular sequelae that lead to scar formation and the initial evaluation of patients with acne scars. Read More

    Ablative Fractional CO2 Laser for Facial Atrophic Acne Scars.
    Facial Plast Surg 2018 Jan 5. Epub 2018 Jan 5.
    Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    Ablative fractional carbon dioxide laser resurfacing is a well-established treatment for acne scars. However, there are limited consensus and guidelines regarding the procedure, such as its treatment plan, efficacy, and safety. In this study, we performed a systematic review to assess the efficacy and safety of the fractional carbon dioxide laser treatment procedure, and to provide evidence-based recommendations concerning its practical use on atrophic acne scars. Read More

    Association of the CYP17 MSP AI (T-34C) and CYP19 codon 39 (Trp/Arg) polymorphisms with susceptibility to acne vulgaris.
    Clin Exp Dermatol 2018 Mar 28;43(2):183-186. Epub 2017 Dec 28.
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
    The aim of this study was to detect the association of the cytochrome P450 (CYP) 17 T-34C and CYP19 TRead More

    Dapsone for topical use in extemporaneous preparations.
    J Dtsch Dermatol Ges 2018 Jan 27;16(1):34-40. Epub 2017 Dec 27.
    Institute for Applied Dermatopharmacy, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
    Background: The sulfone dapsone has an established role in systemic therapy. Its pharmacological and toxicological properties are well known. Topically, dapsone is used in a gel formulation for the treatment of acne vulgaris. Read More

    Selective delivery of adapalene to the human hair follicle under finite dose conditions using polymeric micelle nanocarriers.
    Nanoscale 2018 Jan;10(3):1099-1110
    School of Pharmaceutical Sciences, University of Geneva & University of Lausanne, 1 Rue Michel Servet, 1211 Geneva, Switzerland.
    Drug delivery systems that target the pilosebaceous unit (PSU) selectively could improve the clinical management of diseases that originate in the hair follicle. The aims of this study were (i) to prepare polymeric micelles using d-α-tocopheryl polyethylene glycol succinate diblock copolymer that incorporated adapalene (ADA), a retinoid indicated for Acne vulgaris, and (ii) to investigate the feasibility of delivering ADA preferentially to the PSU under finite dose conditions - thereby better approximating actual conditions of use by patients. Incorporation of ADA into spherical micelles (d<20 nm) increased aqueous solubility by ∼50 000-fold (from <4 ng mLto 0. Read More

    Acne in South African black adults: A retrospective study in the private sector.
    S Afr Med J 2017 Nov 27;107(12):1106-1109. Epub 2017 Nov 27.
    Department of Dermatology, School of Clinical Medicine, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
    Background: Acne vulgaris is the most common skin disorder affecting teenagers and young adults, and is becoming increasingly common in middle-aged women. It affects all skin types and ethnic groups, but dark-skinned individuals are burdened by post-inflammatory hyperpigmentation (PIH) as a sequela. PIH causes distress in acne patients even after the inflammatory lesions have resolved. Read More

    Using Network Oriented Research Assistant (NORA) Technology to Compare Digital Photographic With In-Person Assessment of Acne Vulgaris.
    JAMA Dermatol 2018 Feb;154(2):188-190
    Science 37, Inc, Los Angeles, California.
    Importance: Teledermatology has undergone exponential growth in the past 2 decades. Many technological innovations are becoming available without necessarily undergoing validation studies for specific dermatologic applications.

    Objective: To determine whether patient-taken photographs of acne using Network Oriented Research Assistant (NORA) result in similar lesion counts and Investigator's Global Assessment (IGA) findings compared with in-person examination findings. Read More

    The association between stress and acne among female medical students in Jeddah, Saudi Arabia.
    Clin Cosmet Investig Dermatol 2017 5;10:503-506. Epub 2017 Dec 5.
    Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
    Introduction: Although there is widespread acceptance of a relationship between stress and acne, not many studies have been performed to assess this relationship. The objective of this study was to determine the relationship between stress and acne severity.

    Methods: A cross-sectional study was conducted among 144 6th year female medical students 22 to 24 years in age attending the medical faculty at King Abdulaziz University. Read More

    Gynecologic and andrologic dermatology and the metabolic syndrome.
    Clin Dermatol 2018 Jan - Feb;36(1):72-80. Epub 2017 Sep 8.
    Department of Dermatology,Warren Alpert Medical School of Brown University, Providence, RI; Department of Dermatology, Medical School of Jundiaí, Jundiaí, SP, Brazil, Brazil* GK Dermatology, South Weymouth, MA. Electronic address:
    The relationship of sex hormones to obesity and inflammation has been extensively studied. Research on endogenous and exogenous sex steroids, including studies on animal models of metabolic syndrome (MetS), has indicated that sex hormones are involved in metabolic pathways relevant to MetS. Lower testosterone levels in men and higher levels in women increase risks of MetS and type 2 diabetes mellitus (T2DM). Read More

    Acne vulgaris: The metabolic syndrome of the pilosebaceous follicle.
    Clin Dermatol 2018 Jan - Feb;36(1):29-40. Epub 2017 Sep 8.
    Department of Dermatology, Environmental Medicine and Health Theory, Faculty of Human Sciences, University of Osnabrück, Osnabrück, Germany. Electronic address:
    Acne vulgaris is an epidemic inflammatory disease of the human sebaceous follicle and represents the most common skin disease affecting about 85% of adolescents in Westernized populations. Acne vulgaris is primarily a disease of wealthy countries and exhibits higher prevalence rates in developed compared with developing countries. No acne has been found in non-Westernized populations still living under Paleolithic dietary conditions constraining hyperglycemic carbohydrates, milk, and dairy products. Read More

    Long-term administration of oral macrolides for acne treatment increases macrolide-resistant Propionibacterium acnes.
    J Dermatol 2017 Dec 13. Epub 2017 Dec 13.
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
    Macrolide-resistant Propionibacterium acnes are frequently isolated from patients with acne vulgaris, and the most resistant isolates (>90% resistance) have the 23S rRNA mutation. An increase in resistant P. acnes with this mutation is thought to be caused by the inappropriate use of antimicrobials. Read More

    Calcifying Acne: An Unusual Extraoral Radiographic Finding.
    Case Rep Dent 2017 2;2017:3514936. Epub 2017 Nov 2.
    Bristol Dental School, Lower Maudlin Street, Bristol, BS1 2LY, UK.
    Calcinosis cutis is a condition of accumulation of calcium salts within the dermis leading to the formation of a calcified mass. This complication has been reported in acne vulgaris and other systemic metabolic disorders. This paper presents a rare case of calcinosis cutis in a 14-year-old male which was found at a routine orthodontic assessment. Read More

    Immunohistochemical Expression of Cyclo-oxygenase 2 and Liver X Receptor-α in Acne Vulgaris.
    J Clin Diagn Res 2017 Sep 1;11(9):WC01-WC07. Epub 2017 Sep 1.
    Dermatology Specialist, Faculty of Medicine, Menoufiya University, Shibeen El Koom, Egypt.
    Introduction: Acne Vulgaris (AV) is a common inflammatory disease of pilosebaceous units. Liver X Receptor-α (LXR-α) is a ligand activated transcription factor. It controls transcription of genes involved in lipid and fatty acid synthesis. Read More

    Acne in late adolescence and risk of prostate cancer.
    Int J Cancer 2018 Apr 14;142(8):1580-1585. Epub 2017 Dec 14.
    Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
    Accumulating evidence suggest that Propionibacterium acnes may play a role in prostate carcinogenesis, but data are so far limited and inconclusive. The aim of this population-based cohort study was therefore to test whether presence of acne vulgaris during late adolescence is associated with an increased risk of prostate cancer later in life. We identified a large cohort of young men born in Sweden between 1952 and 1956, who underwent mandatory assessment for military conscription around the age of 18 (n = 243,187). Read More

    Prevalence of Flp Pili-Encoding Plasmids inIsolates Obtained from Prostatic Tissue.
    Front Microbiol 2017 16;8:2241. Epub 2017 Nov 16.
    Department of Biomedicine, Aarhus University, Aarhus, Denmark.
    Inflammation is one of the hallmarks of prostate cancer. The origin of inflammation is unknown, but microbial infections are suspected to play a role. In previous studies, the Gram-positive, low virulent bacterium(formerly)was frequently isolated from prostatic tissue. Read More

    G2A AttenuatesInduction of Inflammatory Cytokines in Human Monocytes.
    Ann Dermatol 2017 Dec 30;29(6):688-698. Epub 2017 Oct 30.
    Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
    Background: Acne vulgaris is a disease of the pilosebaceous unit characterized by increased sebum production, hyperkeratinization, and immune responses to(PA). Here, we explore a possible mechanism by which a lipid receptor, G2A, regulates immune responses to a commensal bacterium.

    Objective: To elucidate the inflammatory properties of G2A in monocytes in response to PA stimulation. Read More

    Evaluation of the effects of acne vulgaris on quality of life in Turkey by using TAQLI.
    J Cosmet Dermatol 2017 Dec 4;16(4):485-490. Epub 2016 Nov 4.
    Department of Statistics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
    Background: Acne vulgaris (AV) is a chronic, inflammatory skin disease that may cause various psychiatric and/or psychological problems.

    Objective: In this study, we aimed to determine the effect of AV on the quality of life in the Turkish population using the Turkish Acne Quality of Life Index (TAQLI).

    Methods: A total of 960 patients with AV who attended the dermatology department were included in the study. Read More

    The role of zinc in the treatment of acne: A review of the literature.
    Dermatol Ther 2018 Jan 28;31(1). Epub 2017 Nov 28.
    Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
    Acne vulgaris is a chronic disease of the pilosebaceous units presenting as inflammatory or noninflammatory lesions in individuals of all ages. The current standard of treatment includes topical formulations in the forms of washes, gels, lotions, and creams such as antibiotics, antibacterial agents, retinoids, and comedolytics. Additionally, systemic treatments are available for more severe or resistant forms of acne. Read More

    A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability.
    An Bras Dermatol 2017 May-Jun;92(3):350-355
    Institute of Dermatology and Venereology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital - Chengdu, China.
    Background: Photodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment.

    Objectives: To compare the efficacy and tolerability of optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional ALA-PDT in treatment of acne vulgaris in rabbit models. Read More

    Dermatologic manifestations of endocrine disorders.
    Transl Pediatr 2017 Oct;6(4):300-312
    The Ohio State University College of Medicine, Columbus, OH, USA.
    The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. Read More

    Clinical behavior of a cohort of adult women with facial acne treated with combined oral contraceptive: ethinylestradiol 20 µg/dienogest 2 mg.
    Int J Womens Health 2017 16;9:835-842. Epub 2017 Nov 16.
    Support for Research, Academic, Scientific and Technological Services (SEACIT), Cali, Colombia.
    Acne vulgaris is the most common skin disease. It affects the young adult female population and generates great impact on physical and mental health. One of the treatments with good results for affected women is combined oral contraceptive pills (COCPs). Read More

    Novel device-based acne treatments: comparison of a 1450-nm diode laser and microneedling radiofrequency on mild-to-moderate acne vulgaris and seborrhoea in Korean patients through a 20-week prospective, randomized, split-face study.
    J Eur Acad Dermatol Venereol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
    Background: While device-based acne treatments are widely applied for patients not tolerating conventional medications, related controlled studies have been still limited. Recently, non-ablative 1450-nm diode laser (DL) and fractional microneedling radiofrequency (FMR) have been effectively used for acne, in addition to well-recognized dermal remodelling effects.

    Objective: To compare the clinical course of acne treatment between DL and FMR. Read More

    Algorithm for acne treatment: Ibero-Latin American consensus.
    An Bras Dermatol 2017 Sep-Oct;92(5):689-693
    Department of Dermatology, School of Medicine. Universidad de Buenos Aires, Argentina.
    Acne is a chronic, immune-mediated, inflammatory disease with high prevalence among adolescents. By compromising face, thorax and back, with the risk of permanent scars, it has a negative impact on the quality of life. Effective, safe and early treatment is the key to remission, while decreasing the risk of physical and/or emotional sequelae. Read More

    Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris.
    J Cosmet Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Background: Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA) has been widely used in clinical practice, its pH ranges from 0.08-2. Read More

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