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    1 OF 227

    Multiple miliary osteoma cutis of the face associated with Albright hereditary osteodystrophy in the setting of acne vulgaris: a case report.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Internal Medicine, University of Central Florida College of Medicine, Orlando Florida.
    Osteoma cutis is a condition characterized by theformation of bone within the skin. Such aberrantossification of the skin and subcutaneous tissue isconsidered primary when it arises in the absence ofunderlying tissue damage or a preceding cutaneouslesion. Conversely, secondary osteoma cutis occurswhen skin ossification is the result of a pre-existingskin lesion, trauma, or inflammatory process [1,2]. Read More

    Retinoids: A Journey from the Molecular Structures and Mechanisms of Action to Clinical Uses in Dermatology and Adverse Effects.
    J Dermatolog Treat 2017 Mar 20:1-56. Epub 2017 Mar 20.
    c Department of Biochemistry and Molecular Genetics , American University of Beirut , Lebanon.
    Retinoids are a class of compounds derived from vitamin A or have structural and/or functional similarity with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. Read More

    Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the Unites States.
    J Drugs Dermatol 2017 Feb;16(2):97-102
    Although there have been few formal studies, scarring is a known bothersome companion of acne vulgaris. We performed a prospective study of subjects consulting a dermatologist for active acne to assess the frequency of acne scarring. Investigators performed a short questionnaire on all acne patients seen at their office for one consecutive 5-day work week to assess scar frequency. Read More

    Adverse effects of isotretinoin: A large, retrospective review.
    Dermatol Ther 2017 Mar 14. Epub 2017 Mar 14.
    Department of Geriatrics, Healthy Ageing Research Centre (HARC), Medical University of Lodz, Pl. Hallera 1, Lodz, 90-647, Poland.
    Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Read More

    Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Mar 11. Epub 2017 Mar 11.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. Read More

    The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.
    Am J Clin Dermatol 2017 Mar 8. Epub 2017 Mar 8.
    Department of Dermatology, University of Illinois at Chicago, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA.
    Background: Acne vulgaris is a highly prevalent skin disorder that affects almost all adolescents and can persist into adulthood. Photodynamic therapy (PDT) is an emerging treatment for acne that involves the use of a photosensitizer in combination with a light source and oxygen.

    Methods: We performed a systematic review of the literature and critically evaluated the studies. Read More

    Therapeutic approaches to reducing atrophic acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):190-194. Epub 2016 Oct 27.
    National and Kapodistrian University of Athens, Athens, Greece.
    Atrophic acne scars are a common and undesirable outcome of acne vulgaris related to both its severity and delay in treatment. Such scars can be classified according to the depth and shape of the collagen loss: ice pick, boxcar, or rolling. The presence of atrophic acne scars can compromise the self-esteem and psychologic well-being of patients, creating a challenge for both the patient and the dermatologist. Read More

    Laser and light-based treatments of acne and acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):183-189. Epub 2016 Oct 27.
    Dermatology and Laser Surgery Center, Yale University School of Medicine, New York, New York , 955 Park Avenue, New York, NY 10028. Electronic address:
    The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy. Read More

    Objective assessment of acne.
    Clin Dermatol 2017 Mar - Apr;35(2):147-155. Epub 2016 Oct 27.
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
    A precise and reliable assessment of acne severity is unarguably the most essential clinical method when it comes to monitoring and choosing optimal treatment in the daily practice. Since the early 1960s, different severity assessment systems have been described in the literature. The two commonly used concepts are global gradings and lesion counting. Read More

    Understanding the role of Propionibacterium acnes in acne vulgaris: The critical importance of skin sampling methodologies.
    Clin Dermatol 2017 Mar - Apr;35(2):118-129. Epub 2016 Oct 27.
    Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden. Electronic address:
    Acne vulgaris is a chronic inflammatory skin condition classified by the Global Burden of Disease Study as the eighth most prevalent disease worldwide. The pathophysiology of the condition has been extensively studied, with an increase in sebum production, abnormal keratinization of the pilosebaceous follicle, and an inflammatory immune response all implicated in its etiology. One of the most disputed points, however, is the role of the gram-positive anaerobic bacterium Propionibacterium acnes in the development of acne, particularly when this organism is also found in normal sebaceous follicles of healthy skin. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    The use of isotretinoin in low doses and unconventional treatment regimens in different types of acne: a literature review.
    Postepy Dermatol Alergol 2017 Feb 7;34(1):1-5. Epub 2017 Feb 7.
    Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
    High effectiveness of isotretinoin treatment for severe types of acne resistant to antibiotics has been widely recognized. However, the recommended doses in conventional therapy, according to consensus of the Polish Dermatological Society, may cause serious adverse effects. Thus, research into less stressful, alternative treatment regimens with the use of low doses of isotretinoin has been carried out. Read More

    Prevalence of acne vulgaris and its impact of the quality of life among secondary school-aged adolescents in Sohag Province, Upper Egypt.
    J Cosmet Dermatol 2017 Mar 2. Epub 2017 Mar 2.
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Upper Egypt, Sohag, Egypt.
    Background: Acne vulgaris is the most common dermatological condition encountered in adolescents.

    Aim: It was to determine the prevalence of acne vulgaris and its impact of the quality of life among adolescents attending secondary schools in Sohag Province, Upper Egypt.

    Patients And Methods: This was a cross-sectional study conducted in randomly selected governmental and technical secondary schools in Sohag Province, Upper Egypt. Read More

    Oral Antibacterial Therapy for Acne Vulgaris: An Evidence-Based Review.
    Am J Clin Dermatol 2017 Mar 2. Epub 2017 Mar 2.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, 11th Floor, New York, NY, 10016, USA.
    Background: To some degree, acne vulgaris affects nearly every individual worldwide. Oral antibiotic therapy is routinely prescribed for the treatment of moderate to severe inflammatory acne; however, long-term use of oral antibiotics for acne may have unintended consequences.

    Objective: The aim of this study was to provide a systematic evaluation of the scientific evidence on the efficacy and appropriate use of oral antibiotics in the treatment of acne. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Feb 28. Epub 2017 Feb 28.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Silk textile with antimicrobial AEM5772/5 (Dermasilk): a pilot study with positive influence on acne vulgaris on the back.
    Int J Dermatol 2017 Feb 27. Epub 2017 Feb 27.
    Center of Aesthetic Medicine, Department of Dermatology, Medical University Graz, Graz, Austria.
    Background: The use of special silk textiles (Dermasilk) has shown positive effects on chronic inflammatory diseases like lichen sclerosus et atrophicus, atopic dermatitis, diabetic ulcerations, and vulvovaginal candidiasis.

    Objective: Wearing T-shirts of this particular fabric could be useful in the management of patients with acne vulgaris on the back and trunk.

    Material And Methods: Dermasilk T-shirts were given to 14 patients with acne vulgaris papulopustulosa on the back. Read More

    Excessive serous retinal detachment during the use of isotretinoin.
    Int Ophthalmol 2017 Feb 25. Epub 2017 Feb 25.
    Ankara Ulucanlar Eye Education and Research Hospital, Ulucanlar Cd. No: 59, 06230, Altindag, Ankara, Turkey.
    Purpose: To report a case unilateral excessive subretinal fluid during the use of isotretinoin.

    Method: A case report. A patient who used isotretinoin orally for nodular-cystic acne vulgaris developed concurrent unilaterally excessive subretinal fluid and serous retinal detachment. Read More

    Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes.
    Front Microbiol 2017 8;8:164. Epub 2017 Feb 8.
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Department of Clinical Immunology, Transplantation Institute, Medical University of WarsawWarsaw, Poland.
    Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Read More

    Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes.
    Ann Dermatol 2017 Feb 3;29(1):20-25. Epub 2017 Feb 3.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
    Background: Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. Read More

    The role of nicotinamide in acne treatment.
    Dermatol Ther 2017 Feb 21. Epub 2017 Feb 21.
    Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
    Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent anti-inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. Read More

    Views of oral antibiotics and advice seeking about acne: a qualitative study of online discussion forums.
    Br J Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    University of Southampton.
    Background: Acne vulgaris is common and can significantly impair quality of life, yet little is known about patients' understanding of acne and its treatments. Oral antibiotics are widely used for acne, despite concerns about antibiotic resistance. People are increasingly turning to online discussion forums for advice and information on these sites may influence health beliefs and treatment adherence. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Emerging Issues in Adult Female Acne.
    J Clin Aesthet Dermatol 2017 Jan 1;10(1):37-46. Epub 2017 Jan 1.
    Dermatology Associates/Research, Coral Gables, Florida.
    Acne vulgaris (acne) is a common affliction in adolescence and is a growing problem in adult women. Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. The long-held dogma that acne in adult women develops on the lower one-third of the face has been recently challenged, and here the authors critically review data from available literature. Read More

    Oral Administration of the Japanese Traditional Medicine Keishibukuryogan-ka-yokuinin Decreases Reactive Oxygen Metabolites in Rat Plasma: Identification of Chemical Constituents Contributing to Antioxidant Activity.
    Molecules 2017 Feb 8;22(2). Epub 2017 Feb 8.
    Center for Advanced Kampo Medicine and Clinical Research, Juntendo Graduate School of Medicine, Tokyo 113-8421, Japan.
    Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Read More

    A Report of Two Cases of Solid Facial Edema in Acne.
    Dermatol Ther (Heidelb) 2017 Mar 6;7(1):167-174. Epub 2017 Feb 6.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Introduction: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published.

    Methods: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. Read More

    Acne vulgaris: Perceptions and beliefs of Saudi adolescent males.
    J Family Community Med 2017 Jan-Apr;24(1):34-43
    Department of Dermatology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
    Introduction: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal.

    Objectives: To evaluate the perceptions and beliefs of Saudi youth on acne.

    Materials And Methods: Three hundred twenty-nine male students (aged 13-22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Read More

    Papular Acne Scars of the Nose and Chin: An Under-recognised Variant of Acne Scarring.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):241-243
    Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
    Background: Scarring following acne vulgaris is common and can be of profound psychosocial consequence.

    Aims And Objectives: We have clinically noted a variant of acne scarring, overlooked by previous categorisation schemes, which we have denominated as papular acne scars of the nose and chin. We sought to characterise these novel entities further. Read More

    Hyaluronic acid decreases lipid synthesis in sebaceous glands.
    J Invest Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. Electronic address:
    Hyaluronic acid (HA) is the major glycosaminoglycan in the extracellular matrix and has been implicated in several functions in skin cells. However, evidence is lacking regarding the HA signaling in sebaceous glands, and its potential role needs to be clarified. We investigated the role of HA in lipid production in sebaceous glands in an experimental study of human sebocytes followed by a clinical study. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Apr;18(2):169-191
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Read More

    Acne and Rosacea.
    Dermatol Ther (Heidelb) 2017 Jan 1;7(Suppl 1):43-52. Epub 2017 Feb 1.
    University of Western Ontario, Windsor, ON, Canada.
    Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Read More

    Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy.
    Curr Eye Res 2017 Jan 31:1-5. Epub 2017 Jan 31.
    c Şanlıurfa Public Health Directorate , Şanlıurfa , Turkey.
    Purpose: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease.

    Method: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study. Read More

    The Role of Androgens and Estrogens in Hidradenitis Suppurativa - A Systematic Review.
    Acta Dermatovenerol Croat 2016 Dec;24(4):239-249
    Peter Theut Riis, MD, Department of Dermatology University Hospital Zealand, Køgevej 7-13, 4000 Roskilde, Denmark;
    Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. Read More

    Draft Genome Sequence of an Erythromycin-Resistant Propionibacterium acnes Isolate Recovered from Folliculitis of the Scalp.
    Genome Announc 2017 Jan 26;5(4). Epub 2017 Jan 26.
    Bacteriology and Hygiene department, Nantes University Hospital, Nantes, France
    Propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. Here, we report the draft genome sequence of an erythromycin-resistant P. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype IA1 and sequence type 18 (ST18). Read More

    A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria.
    Phytother Res 2017 Mar 26;31(3):410-417. Epub 2017 Jan 26.
    School of Pharmacy, De Montfort University, Leicester, UK.
    Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Read More

    Topical delivery of roxithromycin solid-state forms entrapped in vesicles.
    Eur J Pharm Biopharm 2017 Jan 21. Epub 2017 Jan 21.
    Centre of Excellence for Pharmaceutical Sciences (Pharmacen), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
    Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. Read More

    Treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease.
    Sci Rep 2017 Jan 24;7:41325. Epub 2017 Jan 24.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
    Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. Read More

    Efficacy of a twice-daily, 3-step, over-the-counter skincare regimen for the treatment of acne vulgaris.
    Clin Cosmet Investig Dermatol 2017 4;10:3-9. Epub 2017 Jan 4.
    Rodan + Fields, San Francisco, CA, USA.
    Background: Acne vulgaris (acne) is the most common skin disorder producing physical and emotional scars that can persist for years. An estimated 83% of acne sufferers self-treat, but there is lack of studies documenting the effectiveness of over-the-counter (OTC) acne treatment products.

    Objective: This study was conducted to determine the effectiveness of an OTC, 3-step, anti-acne skincare regimen in treating acne and improving the appearance of red/inflamed facial skin. Read More

    Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
    Microbiol Immunol 2017 Jan;61(1):42-44
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
    The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. Read More

    Morbihan disease complicated by dermatosis neglecta: An unique presentation.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Dermatopathology Division, Department of Pathology, Sylvester Comprehensive Cancer Center, Miami, Florida.
    Morbihan disease, also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases. Few cases have been described in the literature, as its first description by Robert Degos in 1957. Read More

    Results of a Phase 2, Randomized,Vehicle-Controlled Study Evaluating the Efficacy,Tolerability, and Safety of Daily or Twice Daily SB204 for the Treatment of Acne Vulgaris.
    J Drugs Dermatol 2016 Dec;15(12):1496-15027
    Objective: This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris.

    Methods: Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12). Read More

    Skin microbiome and acne vulgaris: staphylococcus, a new actor in acne.
    Exp Dermatol 2017 Jan 17. Epub 2017 Jan 17.
    La Roche-Posay Dermatological Laboratories, Asnières, France.
    Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Read More

    Multiple Activities of Punica granatum Linne against Acne Vulgaris.
    Int J Mol Sci 2017 Jan 12;18(1). Epub 2017 Jan 12.
    PhD Program for Clinical Drug Discovery of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. Read More

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