12,817 results match your criteria Acne Vulgaris


Cognitive behavioral therapy as an adjuvant therapy in Acne excoriée: a randomized controlled clinical trial.

J Dermatolog Treat 2020 Jun 5:1-23. Epub 2020 Jun 5.

Mashhad University of Medical Sciences, Mashhad, Iran.

: Acne excoriée (AE) is a difficult challenge in dermatology practice. AE is mostly associated with some psychiatric disorders particularly mood disorders. Thus, patients generally continue to manipulate their lesions. Read More

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http://dx.doi.org/10.1080/09546634.2020.1776207DOI Listing

ARAZLO (Tazarotene 0.045%) Lotion for Topical Treatment of Acne Vulgaris.

Skinmed 2020 1;18(2):102-105. Epub 2020 Mar 1.

Department of Medicine, Baylor University Medical Center, Houston, TX.

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Treatment of acne vulgaris using 1,565 nm non-ablative fractional laser in combination with isotretinoin and pricking blood therapy.

J Dermatolog Treat 2020 Jun 5:1-20. Epub 2020 Jun 5.

Department of Dermatology, Xijing Hospital, the Fourth Military Medical University, Xian, Shaanxi 710032, China.

We aimed to evaluate the efficacy and safety of the 1,565 nm non-ablative fractional laser (NAFL) in combination with isotretinoin and pricking blood therapy (PBT) for treatment of AV. A retrospective analysis of 60 patients with moderate-to-severe AV was performed. Four groups (n = 15) were evaluated: 1,565nm NAFL alone, oral isotretinoin alone, double therapy (NAFL + isotretinoin) and triple therapy (NAFL + isotretinoin + PBT). Read More

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http://dx.doi.org/10.1080/09546634.2020.1773383DOI Listing

Selenium levels and skin diseases: systematic review and meta-analysis.

J Trace Elem Med Biol 2020 May 20;62:126548. Epub 2020 May 20.

Department of Dermatology, The Central Hospital of Enshi Autonomous Prefecture, Enshi 445000, China. Electronic address:

Background: Several studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.

Objective: This systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.

Methods: A systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126548DOI Listing

Novel Rifampicin and Indocyanine Green Co-Loaded Perfluorocarbon Nanodroplets Provide Effective Photo-Chemo-Probiotic Antimicrobility against Pathogen of Acne Vulgaris .

Nanomaterials (Basel) 2020 Jun 1;10(6). Epub 2020 Jun 1.

Department of Biomedical Sciences and Engineering, National Central University. No. 300, Jhongda Rd., Taoyuan City 32001, Taiwan.

Acne vulgaris is one of the most prevalent dermatological diseases among adolescents and is often associated with overgrowth of () in the pilosebaceous units. In this study, we aimed to develop novel rifampicin (RIF) and indocyanine green (ICG) co-loaded perfluorocarbon nanodroplets named RIPNDs which can simultaneously provide photo-, chemo-, and probiotic-antimicrobility, and explore their efficacy in treatment of and . The RIPNDs were first characterized as being spherical in shape, with a size of 238. Read More

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http://dx.doi.org/10.3390/nano10061095DOI Listing

Antibiotic resistance in acne: changes, consequences and concerns.

J Eur Acad Dermatol Venereol 2020 May 31. Epub 2020 May 31.

Department of Dermatology and Cutaneous Biology and Jefferson Center for International Dermatology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Antibiotic resistance in acne was first observed in the 1970s and has been a major concern in dermatology since the 1980s. The resistance rates and types of antimicrobials have subsequently shown great variations in regions and countries. Illustrative of this is the resistance to topical erythromycin and clindamycin which continues to be a problem worldwide, while resistance to systemic treatment with tetracyclines has remained low during the past decade. Read More

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http://dx.doi.org/10.1111/jdv.16686DOI Listing

Risk of keratinocyte carcinoma among patients with hidradenitis suppurativa.

Br J Dermatol 2020 May 30. Epub 2020 May 30.

Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disorder of the pilosebaceous units. To date, studies on the risk of keratinocyte carcinoma (KC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), among HS patients have been limited. We performed a case-control study comparing the incidence of BCC and SCC in HS patients (cases) to that in acne vulgaris patients (controls), which is also an inflammatory disorder of the pilosebaceous unit. Read More

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http://dx.doi.org/10.1111/bjd.19256DOI Listing

Topical Minocycline Foam 4%: A Review in Acne Vulgaris.

Authors:
Julia Paik

Am J Clin Dermatol 2020 Jun;21(3):449-456

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Topical minocycline foam 4% (Amzeeq™) is approved in the USA for the treatment of inflammatory lesions of non-nodular, moderate to severe acne vulgaris (acne) in patients aged ≥ 9 years. It was developed to minimize systemic minocycline absorption and toxicity, and its high lipid content allows efficient drug movement through sebum and into affected sites. The favorable in vitro resistance profile of oral minocycline seen in Cutibacterium acnes (C. Read More

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http://dx.doi.org/10.1007/s40257-020-00523-1DOI Listing

In Vitro Antibacterial and Anti-Inflammatory Effects of Novel Insect Fungus Extract and Its Constituents against .

Antibiotics (Basel) 2020 May 25;9(5). Epub 2020 May 25.

Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.

plays an important role in the pathophysiology of acne vulgaris, the most common chronic inflammatory skin disease of the pilosebaceous unit. This study was conducted to investigate whether the entomopathogenic fungus components have antibacterial and anti-inflammatory effects against that may serve for acne treatment. A chemical study by spectroscopic analysis resulted in the identification of seven known compounds. Read More

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http://dx.doi.org/10.3390/antibiotics9050274DOI Listing

The relationship between acne vulgaris and irritable bowel syndrome: A preliminary study.

J Cosmet Dermatol 2020 May 28. Epub 2020 May 28.

Department of Dermatology, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.

Background: Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by chronic abdominal pain and changes in bowel movements without underlying organic pathology. Many skin diseases have been reported to be more common in individuals with functional bowel diseases.

Aims: In this study, we aimed to investigate a possible relationship between acne vulgaris (AV) and IBS. Read More

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http://dx.doi.org/10.1111/jocd.13481DOI Listing

Comparing clinical acne vulgaris severity to adolescent and parent perceptions of acne severity and impact on quality of life.

Pediatr Dermatol 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background/objectives: Little research has compared clinician acne severity assessment with either adolescent- or parent-rated scales of acne severity or impact on quality of life (QOL). We sought to assess how adolescents and their parents perceive the severity and impact of acne on the adolescent's QOL and correlate this with clinical severity.

Methods: Each adolescent and a parent completed a validated QOL survey regarding the adolescent's acne and rated the adolescent's acne severity and QOL impact using a Likert scale. Read More

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http://dx.doi.org/10.1111/pde.14034DOI Listing

Influence of Contraception Class on Incidence and Severity of Acne Vulgaris.

Obstet Gynecol 2020 Jun;135(6):1306-1312

Departments of Dermatology and Biostatistics, Epidemiology & Informatics, University of Pennsylvania, Philadelphia, Pennsylvania; the Department of Obstetrics, Gynecology & Reproductive Sciences, Bixby Center for Global Reproductive Health, University of California, San Francisco, San Francisco, California; the Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts; and the Department of Dermatology, University of California San Francisco, San Francisco, California.

Objective: To evaluate the association of different contraceptive methods on the incidence and severity of acne.

Methods: Using a de-identified commercial claims database, we performed a retrospective cohort study evaluating the incidence of clinical encounters for acne in the first year after initiation of contraception among female patients aged 12-40 years who were new contraceptive users. To evaluate the association of contraception class with acne severity, a subgroup analysis was performed among a cohort of patients with a history of acne examining the incidence of treatment escalation from topical acne medications to an oral tetracycline-class antibiotic in the year after initiation of contraception. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263356PMC

Knowledge levels and concerns about oral isotretinoin treatment in the parents of adolescent acne patients.

Dermatol Ther 2020 May 27. Epub 2020 May 27.

Department of Dermatology, Medeniyet University, Göztepe Training and Research, Istanbul.

Oral isotretinoin is frequently used in the treatment of young acne patients. However, knowledge levels and attitudes about this treatment have not been studied in the parents previously. We aimed to investigate the knowledge levels and concerns about oral isotretinoin in the parents of adolescent acne patients. Read More

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http://dx.doi.org/10.1111/dth.13669DOI Listing

[Medicaments and oral healthcare. Hyperpigmentation of oral soft tissues due to afamelanotide].

Ned Tijdschr Tandheelkd 2020 Apr;127(4):237-243

The medicament afamelanotide is an analogue of endogenous ?-melanocyte-stimulating hormone. It promotes cutaneous pigmentation, providing protection from sunlight. In dermatology, afamelanotide seems to establish therapeutic results for polymorphic light eruption, solar urticaria, erythropoietic protoporphyria, Hailey-Hailey disease, vitiligo and acne vulgaris. Read More

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http://dx.doi.org/10.5177/ntvt.2020.04.19115DOI Listing

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Esophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic esophagitis, lichen planus, and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic esophagitis is an emerging chronic atopic disease with esophageal dysfunction as the typical presentation, and esophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

Conventional versus daylight photodynamic therapy for acne vulgaris: A randomized and prospective clinical study in China.

Photodiagnosis Photodyn Ther 2020 May 23:101796. Epub 2020 May 23.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Background: Photodynamic therapy (PDT) is an effective and safe treatment modality for acne vulgaris, and a variety of light sources have been investigated. Sunlight has been used as a PDT light source in limited acne studies over the past years. However, to date, a comparative study of conventional PDT (C-PDT) and daylight PDT (DL-PDT) on acne is still lacking. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101796DOI Listing

Contrasting the efficacy of pulsed dye laser and photodynamic methylene blue nanoemulgel therapy in treating acne vulgaris.

Arch Dermatol Res 2020 May 24. Epub 2020 May 24.

Department of Dermatology, Electricity Hospital, Cairo, Egypt.

The treatment of acne remains a challenge for dermatologists. A variety of conventional therapies are available for acne treatment such as topical and systemic medications. Although many of these traditional acne treatments are effective, the wide-spread nature of the disease and its sometimes resistant nature delineate the need for alternative therapies. Read More

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http://dx.doi.org/10.1007/s00403-020-02093-yDOI Listing

Efficacy and safety of Jessner's solution peel in comparison with salicylic acid 30% peel in the management of patients with acne vulgaris and postacne hyperpigmentation with skin of color: a randomized, double-blinded, split-face, controlled trial.

Int J Dermatol 2020 May 24. Epub 2020 May 24.

Dermatology Unit, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Objective: Antibiotics and retinoids have been used for acne vulgaris for decades. Though effective, each has its own drawbacks. Chemical peels have been used for treatment of acne vulgaris with inadequate clinical evidence. Read More

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http://dx.doi.org/10.1111/ijd.14948DOI Listing

Modulation of skin androgenesis and sebum production by a dermocosmetic formulation.

J Cosmet Dermatol 2020 May 20. Epub 2020 May 20.

Kosmoscience Group, Campinas, Brazil.

Background: Excessive androgenesis in the skin promotes sebaceous hyperproduction which is the onset of acne vulgaris pathogenesis. Free fatty acids and lipid accumulation in the glandular infundibulum culminates in microbiota imbalance, triggering inflammatory response and follicular hyperkeratinization.

Aims: The purpose of this work was to present an alternative cosmetic treatment for acne skin care, focusing on the prevention of sebaceous gland dysregulation. Read More

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http://dx.doi.org/10.1111/jocd.13503DOI Listing

The Canadian Dermatology Association's Top Five Choosing Wisely Canada Recommendations.

J Cutan Med Surg 2020 May 20:1203475420928904. Epub 2020 May 20.

2129 Division of Dermatology, Department of Medicine, University of Calgary, AB, Canada.

Introduction: In this article, we present the Canadian Dermatology Association's (CDA) Choosing Wisely Canada (CWC) list of top "Five Things Physicians and Patients Should Question in Dermatology" and the evidence in support of each recommendation.

Methods: Using a nominal technique, the CDA Working Group and Task Force generated an initial list based on literature review and expert consultation. After several rounds of list refinement via a modified Delphi process, a final list of recommendations was generated. Read More

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http://dx.doi.org/10.1177/1203475420928904DOI Listing

Non-Prescription Acne Vulgaris Treatments: Their Role in our Treatment Armementarium: An International Panel Discussion.

J Cosmet Dermatol 2020 May 19. Epub 2020 May 19.

Department of Clinical Medicine and Surgery, Dermatology, Section of Dermatology, University of Naples Federico II, Naples, Italy.

Background: Acne vulgaris (Acne), a common inflammatory skin disorder, has its peak incidence between 14 - 19 years of age, with girls, frequently developing acne earlier than boys. Over recent years persistent acne is becoming more prevalent in adult women.

Objectives: This review and panel discussion addresses challenges in acne management, particularly in adult women. Read More

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http://dx.doi.org/10.1111/jocd.13497DOI Listing

Characterization of acne patients carrying clindamycin-resistant Cutibacterium acnes: A Japanese multicenter study.

J Dermatol 2020 May 18. Epub 2020 May 18.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Use of antimicrobials for acne treatment is correlated with an increased occurrence of antimicrobial-resistant Cutibacterium acnes. To clarify the role of antimicrobial use on the resistance and to investigate the characteristics of resistant strains, we conducted a multicenter study in dermatological clinics frequently visited by new patients with acne vulgaris. We collected specimens in 264 acne patients and tested 164 C. Read More

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http://dx.doi.org/10.1111/1346-8138.15397DOI Listing

The investigation of the amounts and expressions of epidermal growth factor, epidermal growth factor receptor and epidermal growth factor receptor gene polymorphisms in acne vulgaris.

J Cosmet Dermatol 2020 May 18. Epub 2020 May 18.

İstanbul University, Cerrahpaşa Faculty of Medicine, Department of Medical Biology.

Aim: Epidermal growth factor receptor inhibitors (EGFRI) used in cancer chemotherapy cause acneiform folliculitis in 70-100% of patients in a dose-dependent manner. Acneiform folliculitis is considered to be caused by an inflammatory process due to follicular hyperkeratosis and subsequently a set of changes both in epidermis and hair follicles as a result of epidermal growth factor receptor (EGFR) blockade. Both acne vulgaris and acneiform folliculitis due to EGFRIs show similar changes in the pilosebaceous unit. Read More

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http://dx.doi.org/10.1111/jocd.13498DOI Listing

Incidence of low back pain and sacroiliitis in military families with acne vulgaris under isotretinoin therapy.

Am J Clin Exp Immunol 2020 15;9(2):6-9. Epub 2020 Apr 15.

School of Pharmacy, Islamic Azad University of Tehran Tehran, Iran.

Background: Acne vulgaris is a common complication that patients referred to dermatologist, also there are medications to manage of this such as isotretinoin, and incidence of low back pain in these patients is more than general population, so in this study we aimed to evaluate of Incidence of low back pain and sacroiliitis in military families with acne vulgaris under isotretinoin therapy.

Methods: This cross-sectional study was performed on 113 acne vulgaris patients treated with isotretinoin (at least 3 months) referred to dermatology clinic of Imam Reza Hospital of Army Medical Sciences, Tehran, Iran during 2018 to 2019. All data of patients such as dosage and duration of medication, severity of acne, incidence of low back pain, sacroiliitis and inflammatory back pain and lab data were recorded. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218680PMC

Efficacy of acne vulgaris treatment protocols according to its clinical forms.

Dermatol Ther 2020 May 17:e1361. Epub 2020 May 17.

Central Michigan University, Saginaw, Michigan, USA.

To compare results of different treatment regimens based on stratification of acne to prescribe the right treatment protocol according to clinical form and grade of acne. A transversal, cohort study conducted in 230 patients with acne vulgaris. Patients were divided into three groups according to acne severity and the results of each protocol determined in 0, 4, 6, 8, 12, 18 and 24 weeks. Read More

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http://dx.doi.org/10.1111/dth.13611DOI Listing
May 2020
1.478 Impact Factor

Tissue expression of IL-17A and FOXP3 in acne vulgaris patients.

J Cosmet Dermatol 2020 May 15. Epub 2020 May 15.

Dermatology, Andrology and STDs Department, Faculty of Medicine, Menoufia University, Shebin ElKom, Egypt.

Background/objectives: CD4  T helper (Th) cells through its pro-inflammatory cell type, interleukin-17 (IL-17)-generating cells and its anti-inflammatory category forkhead box P3-positive (FOXP3 ) regulatory T (Treg) cells, play a vital role in the immune balance in inflammatory disorders. Therefore, assessment of both IL-17 and FOXP3 in acne vulgaris (AV), a chronic inflammatory disease of the pilosebaceous unit, could be of value in understanding AV pathogenesis. This study aimed to investigate the immunohistochemical expression of IL-17A and FOXP3 in acne vulgaris lesions versus normal skin. Read More

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http://dx.doi.org/10.1111/jocd.13485DOI Listing

A patient with chronic sacroiliitis undiagnosed for three years after isotretinoin use.

BMC Musculoskelet Disord 2020 May 14;21(1):300. Epub 2020 May 14.

Department of Physical Medicine and Rehabilitation, Health Sciences University Ankara Training and Research Hospital, Ankara, Turkey.

Background: Isotretinoin (ISO) is a synthetic vitamin A derivative which has been used for treatment-resistant acne vulgaris. Although most musculoskeletal side effects of ISO are common, including myalgia, arthralgia, and back pain, sacroiliitis is one of the uncommon side effects. ISO-induced sacroiliitis usually completely resolves within a few months by the cessation of the drug. Read More

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http://dx.doi.org/10.1186/s12891-020-03290-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227041PMC

Evaluation of reliability and validity of the patient health questionnaire-9 in patients with acne.

Dermatol Ther 2020 May 14:e13584. Epub 2020 May 14.

Department of Dermatology, The First Affiliated Hospital of WenZhou Medical University, WenZhou, China.

To evaluate the reliability and validity of the Patient Health Questionnaire-9(PHQ-9) in patients with acne. 300 acne patients were enrolled from January 2019 to December 2019.PHQ-9 and Hamilton Depression Scale(HAMD) survey was conducted to evaluate their depression status. Read More

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http://dx.doi.org/10.1111/dth.13584DOI Listing

A young male with epitheliolysis in the small bowel and colon.

Scand J Gastroenterol 2020 May 12:1-3. Epub 2020 May 12.

Department of Medicine, Haukeland University Hospital, Bergen, Norway.

Toxic epidermal necrolysis (TEN) is characterized by epidermal necrosis of various degree, and can affect the entire body surface. Affection of small bowel and colon is a rare manifestation of TEN. We present a case with an unusual appearance of epitheliolysis of the small bowel and colon due to a toxic reaction. Read More

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http://dx.doi.org/10.1080/00365521.2020.1760344DOI Listing

A retrospective assessment and comparison of the effectiveness of benzoyl peroxide, the combination of topical niacinamide, gallic acid and lauric acid and the combination of benzoyl peroxide and erythromycin in acne vulgaris.

Dermatol Ther 2020 May 10. Epub 2020 May 10.

Dermatology Department, Cumhuriyet University School of Medicine, Sivas, Turkey.

Acne vulgaris is a chronic inflammatory skin disease that mostly develops during adolescence and continues throughout adulthood. It affects the face, the main location of cosmetic appearance. Despite many developments in acne treatment, various combination therapies are needed to create the best option. Read More

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http://dx.doi.org/10.1111/dth.13534DOI Listing

An overview of treatment options for mild-to-moderate acne based on American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology guidelines.

Dermatol Ther 2020 May 8:e13548. Epub 2020 May 8.

Dermatology Section, Department of Plastic, Reconstructive and Cosmetic Surgery, Campus Biomedico University Hospital, Rome, Italy.

Acne is a common inflammatory skin disorder affecting the pilosebaceous unit. Patients with mild-to-moderate acne can be treated with a combination of topical, systemic, and physical therapeutic approaches, with different results depending on patient, disease, and treatment characteristics. Herein we describe and discuss the common and alternative treatment options used for mild-to-moderate acne, by comparing three widely distributed guidelines (American Academy of Dermatology, European Academy of Dermatology and Venereology, and Italian Society of Dermatology and Venereology. Read More

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http://dx.doi.org/10.1111/dth.13548DOI Listing

The efficacy and safety of a 577-nm high-power optically pumped semiconductor laser in the treatment of postacne erythema.

J Cosmet Dermatol 2020 May 8. Epub 2020 May 8.

Carol Davila University of Medicine and Pharmacy, Bucharest, ROMANIA.

Background: Postacne erythema (PAE) is a common sequela of inflammatory acne vulgaris. Treatment of which has been challenging due to limited options available and the variability of results for each modality. Recently, a 577-nm high-power optically pumped semiconductor laser (HOPSL) initially developed for vascular lesions, has shown promising results for the treatment of PAE. Read More

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http://dx.doi.org/10.1111/jocd.13474DOI Listing

Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of by Anti-Inflammatory Activity and 5α-Reductase Inhibition.

Molecules 2020 May 5;25(9). Epub 2020 May 5.

Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.

(QM)-a member of the Fagaceae family-has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). Read More

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http://dx.doi.org/10.3390/molecules25092154DOI Listing

Skin disorders among children living in orphanage centres in Dar es Salaam, Tanzania.

Trop Med Health 2020 30;48:29. Epub 2020 Apr 30.

2Department of Internal Medicine, School of Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.

Background: Skin conditions contribute significantly to the global burden of diseases and are among the leading causes of non-fatal disease burden. Children living in orphanage centres are vulnerable to several conditions including dermatological disorders, and there is limited data on the burden of these conditions among orphans in Tanzania. This study was carried out to determine the pattern of dermatological conditions and contributing factors among orphans in Dar es Salaam, Tanzania. Read More

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http://dx.doi.org/10.1186/s41182-020-00216-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191825PMC

Modified 5-aminolevulinic acid photodynamic therapy to reduce pain in the treatment of moderate to severe acne vulgaris: A prospective, randomized split-face study.

J Am Acad Dermatol 2020 May 3. Epub 2020 May 3.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.146DOI Listing

Development and Evaluation of Azelaic Acid-Loaded Microemulsion for Transfollicular Drug Delivery Through Guinea Pig Skin: A Mechanistic Study.

Adv Pharm Bull 2020 Jun 18;10(2):239-246. Epub 2020 Feb 18.

Department of Physics, University of Zabol, Zabol, Iran.

Azelaic acid is a natural keratolytic, comedolytic, and antibacterial drug that is used to treat acne. The topical application of azelaic acid is associated with problems such as irritation and low permeability. For dissolving, the problem is that microemulsion (ME) is used as a drug carrier. Read More

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http://dx.doi.org/10.34172/apb.2020.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191225PMC

High-Frequency Ultrasonography and Scoring of Acne at 20 MHz and 50 MHz.

J Eur Acad Dermatol Venereol 2020 May 5. Epub 2020 May 5.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.

Effective management of acne vulgaris requires accurate assessment. High-frequency ultrasonography (HF-USG) provides an objective and non-invasive evaluation in comparison with naked-eye evaluation or pathological examination. To explore the ultrasonographic features of acne vulgaris and assess the role of HF-USG in the classification of acne. Read More

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http://dx.doi.org/10.1111/jdv.16584DOI Listing

pH-Dependent Antibacterial Activity of Glycolic Acid: Implications for Anti-Acne Formulations.

Sci Rep 2020 May 4;10(1):7491. Epub 2020 May 4.

School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue 639798, Singapore, Singapore.

Glycolic acid is the smallest alpha hydroxy acid and widely used for skincare applications, including to treat acne vulgaris. Oftentimes, high concentrations of glycolic acid (~20-50 vol%) are incorporated into chemical peels to reduce acne-related inflammation while there is an outstanding need to determine to what extent glycolic acid can potently inhibit Cutibacterium acnes (formerly known as Propionibacterium acnes), which is a Gram-positive bacterium implicated in acne pathogenesis. Herein, we report that glycolic acid exhibits pH-dependent antibacterial activity against C. Read More

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http://dx.doi.org/10.1038/s41598-020-64545-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198592PMC

Antibacterial PEGylated Solid Lipid Microparticles for Cosmeceutical Purpose: Formulation, Characterization, and Efficacy Evaluation.

Materials (Basel) 2020 Apr 30;13(9). Epub 2020 Apr 30.

Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF) Università degli Studi di Palermo, 90128 Palermo, Italy.

The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against infections responsible for many skin disorders, such as acne vulgaris. In this study, solid lipid microparticles are designed as composite vehicles capable of encapsulating a high amount of trans-RSV and enhancing its absorption through the stratum corneum. Read More

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http://dx.doi.org/10.3390/ma13092073DOI Listing

Treatment-seeking behavior, knowledge and beliefs about Acne Vulgaris among adolescents: A cross-sectional study in high school students in Tirana, Albania.

Dermatol Ther 2020 May 2. Epub 2020 May 2.

Central Michigan University, Saginaw, Michigan, USA.

Acne vulgaris is a common adolescents' disorder. Nevertheless, there is lack of knowledge about acne among adolescents. To evaluate the adolescents' knowledge and beliefs about acne, to investigate help-seeking behavior and treatment preferences. Read More

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http://dx.doi.org/10.1111/dth.13500DOI Listing

Observation for clinical effect of acupuncture combined with conventional therapy in the treatment of acne vulgaris.

Medicine (Baltimore) 2020 May;99(18):e19764

Department of Dermatology, Huabei Petroleum General Hospital, China.

Introduction: Acne vulgaris is a chronic inflammatory disease of the sebaceous glands that occurs in adolescent men and women. In recent years, the incidence of acne has increased year by year, so it is of great significance to find a precise and effective treatment and further explore its possible mechanism of action. The purpose of this study will be to explore a treatment method that has both traditional Chinese medicine characteristics and significant effects, and provides a higher level of evidence for acupuncture for acne vulgaris. Read More

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http://dx.doi.org/10.1097/MD.0000000000019764DOI Listing

Current Issues in the Treatment of Acne Vulgaris.

Pediatrics 2020 May;145(Suppl 2):S225-S230

Department of Dermatology, The Johns Hopkins Hospital, Baltimore, Maryland

Acne vulgaris is an extraordinarily common skin condition in adolescents. The mainstays of acne treatment have remained largely unchanged over recent years. In the context of increasing antibiotic resistance worldwide, there is a global movement away from antibiotic monotherapy toward their more restrictive use. Read More

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http://dx.doi.org/10.1542/peds.2019-2056LDOI Listing

Open-Label, Long-Term Extension Study to Evaluate the Safety of Clascoterone (CB-03-01) Cream, 1% BID in Subjects with Acne Vulgaris.

J Am Acad Dermatol 2020 Apr 26. Epub 2020 Apr 26.

Cassiopea S.p.A., Via Cristoforo Colombo 1, 20020 Lainate, Italy.

Background: Androgens foster acnegenic pathways.

Objective: To assess the long-term safety of an androgen receptor inhibitor clascoterone cream, 1%, in subjects who participated in Phase 3 studies.

Methods: Clascoterone cream was applied twice daily for up to nine months to the face and/or trunk. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.04.087DOI Listing

Adverse events related to topical drug treatments for acne vulgaris.

Expert Opin Drug Saf 2020 Apr;19(4):513-521

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

: Acne vulgaris is a widespread skin disease. Topical therapy is a standard treatment for mild to moderate acne. Given the complex pathophysiology of acne, various agents with complementary action are nowadays frequently combined to increase the efficacy of therapy. Read More

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http://dx.doi.org/10.1080/14740338.2020.1757646DOI Listing

A retrospective evaluation of routine isotretinoin laboratory monitoring in patients above 35 years old.

J Am Acad Dermatol 2020 Apr 25. Epub 2020 Apr 25.

Department of Dermatology, Brigham and Women's Hospital, Boston MA. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.106DOI Listing

High levels of Helicobacter pylori antigens and antibodies in patients with severe acne vulgaris.

J Cosmet Dermatol 2020 Apr 25. Epub 2020 Apr 25.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Background: Helicobacter pylori (H pylori) may play a role in the pathogenesis of extra-intestinal disorders including dermatological diseases.

Aims: This study aimed to assess the levels of H pylori antigen and antibody in patients with acne vulgaris (AV).

Methods: This cross-sectional study compared the levels of fecal H pylori antigen and serum H pylori antibody in 100 patients with AV and 100 age and sex-matched healthy volunteers. Read More

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http://dx.doi.org/10.1111/jocd.13409DOI Listing
April 2020
1.000 Impact Factor

Segmentation methods for acne vulgaris images: Proposal of a new methodology applied to fluorescence images.

Skin Res Technol 2020 Apr 24. Epub 2020 Apr 24.

Department of Graphics Engineering, Centro de Investigación en Tecnologías Gráficas (CITG), Universitat Politècnica de València (UPV), Valencia, Spain.

Background: Acne vulgaris is one of the most common human pathologies worldwide. Its prevalence causes a high healthcare expenditure. Acne healthcare costs and effects on individuals' quality of life lead to the need of analysing current acne evaluation, treatment and monitoring methods. Read More

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http://dx.doi.org/10.1111/srt.12865DOI Listing

Hidradenitis suppurativa in pediatric patients: a retrospective monocentric study in Germany and review of the literature.

J Eur Acad Dermatol Venereol 2020 Apr 23. Epub 2020 Apr 23.

Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany.

Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, debilitating skin disease of the hair follicle affecting apocrine glands-rich areas of the body. The disease usually occurs after puberty leading to painful nodules, abscesses, tunnels and scarring. Although uncommonly, HS can also occur in children and adolescents. Read More

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http://dx.doi.org/10.1111/jdv.16520DOI Listing

A novel homozygous c.67C>T variant in retinol binding protein 4 (RBP4) associated with retinitis pigmentosa and childhood acne vulgaris.

Ophthalmic Genet 2020 Apr 23:1-5. Epub 2020 Apr 23.

Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

: The retinol binding protein 4 (RBP4) is essential in delivering retinol to the retinal pigment epithelium and normal functioning of the visual cycle. Homozygous mutations in the RBP4 gene lead to severe retinitis pigmentosa that is phenotypically indistinguishable from retinitis pigmentosa caused by other recessive mutations.: Case Report. Read More

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http://dx.doi.org/10.1080/13816810.2020.1755985DOI Listing

Prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population.

Arch Dermatol Res 2020 Apr 22. Epub 2020 Apr 22.

Institute for Health Services Research in Dermatology and Nursing (IVDP), University Medical Center Hamburg-Eppendorf (UKE), Martinistraße 52, 20246, Hamburg, Germany.

The association of hidradenitis suppurativa with other skin diseases has not yet been investigated in larger studies based on dermatological exams. The objectives of this study are to determine the prevalence and cutaneous comorbidities of hidradenitis suppurativa in the German working population. Between 2014 and 2017, 20,112 people in 343 German companies were examined for the presence of clinical features of hidradenitis suppurativa within the framework of a cross-sectional epidemiological study based on whole-body examinations. Read More

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http://dx.doi.org/10.1007/s00403-020-02065-2DOI Listing