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    Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris.
    J Invest Dermatol 2017 Jul;137(7):1405-1408
    Department of Dermatology, Environmental Medicine, Health Theory, Faculty of Human Sciences, University of Osnabrück, Osnabrück, Germany. Electronic address:
    Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Read More

    Isotretinoin and lymecycline treatments modify the skin microbiota in acne.
    Exp Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Read More

    Oxidative stress and psychiatric morbidity in patients with facial acne.
    J Cosmet Dermatol 2017 Jun 20. Epub 2017 Jun 20.
    Faculty of Medicine, Department of Neuropsychiatry, Assiut University, Assiut, Egypt.
    Background: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne.

    Objective: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. Read More

    Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial.
    BMC Complement Altern Med 2017 Jun 17;17(1):318. Epub 2017 Jun 17.
    Department of Ophthalmology & Otolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
    Background: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Read More

    Antimicrobial susceptibility and phylogenetic analysis of Propionibacterium acnes isolated from acne patients in Japan between 2013 and 2015.
    J Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
    The prevalence of antimicrobial-resistant Propionibacterium acnes strains isolated from acne patients has been increasing in Japan. Here, to estimate the current resistance rate, we tested antimicrobial susceptibility among P. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. Read More

    Evidence-based recommendations for the management of acne fulminans and its variants.
    J Am Acad Dermatol 2017 Jul;77(1):109-117
    University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
    Background: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. Read More

    Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City.
    Dermatology 2017 Jun 14. Epub 2017 Jun 14.
    Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
    Background: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors.

    Objective: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. Read More

    Differences in Dietary Glycemic Load and Hormones in New York City Adults with No and Moderate/Severe Acne.
    J Acad Nutr Diet 2017 Jun 9. Epub 2017 Jun 9.
    Background: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis.

    Objective: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. Read More

    A Polycation Antimicrobial Peptide Mimic without Resistance Buildup against Propionibacterium Acnes.
    Macromol Biosci 2017 Jun 12. Epub 2017 Jun 12.
    Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23219, USA.
    A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Read More

    Mechanistic analysis of human skin distribution and follicular targeting of adapalene loaded biodegradable nanospheres with an insight into hydrogel matrix influence, in-vitro skin irritation and in-vivo tolerability.
    J Pharm Sci 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Granada University, Granada, Spain.
    This work aimed at the development of a biocompatible, non-oily nanomedicine for follicular delivery of adapalene (AD) ameliorating its irritation potential for convenient localized topical treatment of acne vulgaris. AD was efficiently incorporated into poly-Ԑ-caprolactone nanospheres (NS) with an encapsulation efficiency of (84.73± 1. Read More

    A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.
    Mayo Clin Proc 2017 Jun 7. Epub 2017 Jun 7.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach.

    Patients And Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011.

    Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Read More

    Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic-Resistant Acne-Related Bacteria.
    Mar Drugs 2017 Jun 8;15(6). Epub 2017 Jun 8.
    Department of Food Science and Technology, Pukyong National University, Busan 48547, Korea.
    The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, one of the most common skin diseases. Acne vulgaris is often associated with acne-related bacteria such as Propionibacteriumacnes, Staphylococcusepidermidis, Staphylococcusaureus, and Pseudomonasaeruginosa. Some of these bacteria exhibit a resistance against commercial antibiotics that have been used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). Read More

    Genetic architecture of acne vulgaris.
    J Eur Acad Dermatol Venereol 2017 Jun 7. Epub 2017 Jun 7.
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.
    Background: Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation.

    Objective: Here we review our current understanding of the genetic architecture of this intriguing disease and want to show rare and corresponding diseases like PCOS with acne vulgaris.

    Methods: We conducted a data research identifying genome-wide association studies (GWAS), candidate genes studies as case reports for acne vulgaris. Read More

    Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.
    Front Pharmacol 2017 22;8:278. Epub 2017 May 22.
    Department of Dermatology, University Hospital ZurichZurich, Switzerland.
    In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components. Read More

    Why Topical Retinoids Are Mainstay of Therapy for Acne.
    Dermatol Ther (Heidelb) 2017 Jun 5. Epub 2017 Jun 5.
    Gwinnett Dermatology, PC, and Gwinnett Clinical Research Center, Inc., Snellville, GA, USA.
    Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease. Read More

    In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesions.
    Arch Dermatol Res 2017 May 31. Epub 2017 May 31.
    Department of Skin Biology and Pharmacology, The Johnson & Johnson Skin Research Center, Johnson & Johnson Consumer Inc., 199 Grandview Road, Skillman, NJ, 08558, USA.
    Acne vulgaris is a disease of pilosebaceous units with multifactorial pathogenesis, including hyperkeratinization, increased sebum secretion, and inflammation. Recently, it was suggested that acne subjects may have also impaired skin barrier. We hypothesized that excess unsaturated free fatty acids (UFFA) present in the sebum may cause barrier impairment associated with increased follicular stratum corneum (SC) thickening and inflammation seen in acne. Read More

    Endocrine disorders and hormonal therapy for adolescent acne.
    Curr Opin Pediatr 2017 May 27. Epub 2017 May 27.
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
    Purpose Of Review: Acne vulgaris is a global disease with increasing prevalence in adolescents. It has a profound impact on their quality of life, especially when endocrine disorders are also involved. Recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant Propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. Read More

    The age-old problem of acne.
    Int J Womens Dermatol 2017 Jun 2;3(2):71-76. Epub 2016 Dec 2.
    Department of Dermatology, Warwick Hospital, Lakin Road, Warwick, United Kingdom.
    Acne vulgaris is one of the top three most commonly encountered dermatological problems worldwide in both primary and secondary care. Acne diagnosis and treatment date back to ancient Greek and Egyptian times. This article explores acne through the ages and discusses past theories on etiology and treatment with particular focus on the discovery of retinoids and their impact on women's health. Read More

    Acne: morphologic and vascular study of lesions and surrounding skin by means of optical coherence tomography.
    J Eur Acad Dermatol Venereol 2017 May 30. Epub 2017 May 30.
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Acne vulgaris is a disease of the pilosebaceous unit, characterized by hyper-keratinization process, comedos formation and inflammatory reactions.

    Objective: The definition of the morphology and the vascularization of acne lesions by means of dynamic optical coherence tomography (D-OCT), in order to non-invasively define the alterations occurring during the acne development and patient therapeutic management.

    Methods: A set of standardized clinical pictures and D-OCT images were acquired from 114 acne lesions of 31 volunteers, presenting mild to moderate acne and evaluated by experts. Read More

    Microneedles in the clinic.
    J Control Release 2017 May 23;260:164-182. Epub 2017 May 23.
    Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, India. Electronic address:
    In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Read More

    Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.
    An Bras Dermatol 2017 Mar-Apr;92(2):212-216
    Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah - Sabah, Malaysia.
    Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Read More

    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    A Retrospective Study of Multiple Sequential Light and Laser Sources to Activate Aminolevulinic Acid in the Treatment of Acne Vulgaris.
    Skinmed 2017 1;15(2):105-111. Epub 2017 Apr 1.
    Goldman, Butterwick, Fitzpatrick, Groff, and Fabi: Cosmetic Laser Dermatology, San Diego, CA.
    Reports of the sequential use of multiple light and laser sources for topical 5-aminolevulinic acid (ALA) activation in photodynamic therapy (PDT) of inflammatory acne vulgaris are lacking. The authors sought to retrospectively compare field-directed ALA-PDT with blue light only, blue light + pulsed dye laser (PDL), blue light + intense pulsed light (IPL), blue light + PDL + IPL, or blue light + red light + PDL + IPL for inflammatory acne of the face or upper trunk. Results showed a trend toward greater patient-reported improvement with comparable tolerability using multiple, sequential light sources in ALA-PDT for acne vulgaris, albeit not statistically significant. Read More

    Edible Plants and Their Influence on the Gut Microbiome and Acne.
    Int J Mol Sci 2017 May 17;18(5). Epub 2017 May 17.
    Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA.
    Acne vulgaris affects most people at some point in their lives. Due to unclear etiology, likely with multiple factors, targeted and low-risk treatments have yet to be developed. In this review, we explore the multiple causes of acne and how plant-based foods and supplements can control these. Read More

    Non-ablative fractional laser-assisted daylight photodynamic therapy with topical methyl aminolevulinate for moderate to severe facial acne vulgaris: Results of a randomized and comparative study.
    Photodermatol Photoimmunol Photomed 2017 May 13. Epub 2017 May 13.
    Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
    Background: Photodynamic therapy (PDT) has been reported as an effective alternative treatment for patients with acne.

    Purpose: To evaluate the efficacy and safety of DL-PDT in moderate to severe acne and to compare outcomes with those of laser-assisted daylight photodynamic therapy.

    Methods: Patients were randomly assigned to either a DL-PDT group (D group) or a fractional laser-assisted DL-PDT group (F group). Read More

    A Review of hormone-based therapies to treat adult acne vulgaris in women.
    Int J Womens Dermatol 2017 Mar 30;3(1):44-52. Epub 2017 Mar 30.
    Department of Dermatology, University of California San Francisco, San Francisco, CA.
    Hormone-based therapies including combined oral contraceptive medications and spironolactone are considered effective therapies to treat adult acne in women. Our objective is to provide a concise and comprehensive overview of the types of hormonal therapy that are available to treat acne and comment on their efficacy and safety profiles for clinical practice. A systematic search using the PubMed Database was conducted to yield 36 relevant studies for inclusion in the review and several conclusions were drawn from the literature. Read More

    Randomized, controlled trial split-faced study of 595-nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood.
    Int J Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
    The high prevalence of acne vulgaris in teenagers has increased comorbidities. Lasers offer alternative options for acne treatment because they have rapid action, low systemic adverse effects, and do not require everyday treatment. To study the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood, we designed a blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm(3) pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study in patients with mild to moderate acne by comparing the laser-treated and non-treated side. Read More

    Prioritizing treatment outcomes: How people with acne vulgaris decide if their treatment is working.
    J Evid Based Med 2017 Apr 26. Epub 2017 Apr 26.
    National Institute for Health and Clinical Effectiveness, City Tower, Piccadilly Plaza, Manchester, UK.
    Objective: To collect information about how people with acne make day-to-day decisions concerning the effectiveness of their treatment.

    Methods: Between May and August 2013, an optional question was embedded in the James Lind Alliance Acne Priority Setting Partnership's online survey to collect treatment uncertainties. The question asked people with acne to "Tell us in your own words how you decide if your treatment has been effective. Read More

    Over-the-counter and Prescription Medications for Acne: A Cross-Sectional Survey in a Sample of University Students in Saudi Arabia.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):120-123
    Department of Dermatology, College of Medicine, King Faisal University, Saudi Arabia.
    Introduction And Background: Acne is a very common dermatological condition found among the adolescent population in Saudi Arabia. Many patients with acne try various forms of self-medication, over the counter medicines (OTC), and prescription medicines for the same.

    Materials And Methods: This was a cross-sectional study among university students in the Kingdom of Saudi Arabia (KSA). Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Improvement of Atrophic Acne Scars in Skin of Color Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study.
    J Drugs Dermatol 2017 Apr;16(4):322-326

    BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.

    OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color. Read More

    Clindamycin phosphate-tretinoin combination gel revisited: status report on a specific formulation used for acne treatment.
    Cutis 2017 Mar;99(3):179-183
    JDR Dermatology Research LLC/Thomas Dermatology, Las Vegas and Henderson, Nevada, and Touro University Nevada, Henderson, USA.
    Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Read More

    Bactericidal activity and post-antibiotic effect of ozenoxacin against Propionibacterium acnes.
    J Infect Chemother 2017 Jun 4;23(6):374-380. Epub 2017 Apr 4.
    Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Japan.
    Ozenoxacin, a novel non-fluorinated topical quinolone, is used for the treatment of acne vulgaris in Japan. We investigated bactericidal activity and post-antibiotic effect (PAE) of ozenoxacin against Propionibacterium acnes, a major causative bacterium of acne vulgaris. The minimum inhibitory concentrations (MICs) of ozenoxacin against 3 levofloxacin-susceptible strains (MIC of levofloxacin; ≤4 μg/mL) and 3 levofloxacin-resistant strains (MIC of levofloxacin; ≥8 μg/mL) ranged from 0. Read More

    New Uses of AbobotulinumtoxinA in Aesthetics.
    Aesthet Surg J 2017 May;37(suppl_1):S45-S58
    Dr Schlessinger is a dermatologist and cosmetic surgeon in private practice in Omaha, NE. Dr Gilbert is a dermatologist in private practice in Brooklyn, NY. Dr Cohen is a dermatologist in private practice in Greenwood Village, CO. Dr Kaufman is dermatologist in private practice in Miami, FL.
    BotulinumtoxinA (BoNT-A) is now widely established for the main approved indication of reducing glabellar lines, and is also widely used off-label to improve the appearance of wrinkles and lines in other parts of the face. The number of aesthetic procedures continues to increase as the patient population becomes more diverse, in particular with increasing numbers of people of color and men. Further developments in treatment may continue to expand the audience for BoNT-A by making procedures more comfortable and by delivering a more natural, less static appearance. Read More

    AbobotulinumtoxinA: A 25-Year History.
    Aesthet Surg J 2017 May;37(suppl_1):S4-S11
    Dr Monheit is a Dermatologist, Departments of Dermatology and Ophthalmology, University of Alabama at Birmingham, Birmingham, AL. Dr Pickett is Director and Founder of Toxin Science Limited, Wrexham, UK; and an Adjunct Professor at the Botulinum Research Center, Institute of Advanced Sciences, Dartmouth, MA.
    During the late 1960s and early 1970s, Alan Scott showed that intramuscular injections of botulinum toxin (BoNT) corrected nonaccommodative strabismus without resorting to surgery. The UK doctors who trained with Scott soon realized the significant potential offered by BoNT type A as a therapeutic option for several difficult-to-treat diseases. This led to a collaboration between these pioneering clinicians and the Centre for Applied Microbiology and Research at Porton Down, United Kingdom, and, in turn, to the development and commercialization of abobotulinumtoxinA as Dysport (Dystonia/Porton Down; Ipsen Biopharm Ltd. Read More

    A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
    Int J Dermatol 2017 Jun 30;56(6):686-690. Epub 2017 Mar 30.
    Research and Development Division, United Laboratories, Inc., Mandaluyong City, Philippines.
    Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months. Read More

    Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats.
    Tissue Cell 2017 Apr 9;49(2 Pt B):203-208. Epub 2017 Mar 9.
    Department of Structural and Functional Biology, Biology Institute, State University of Campinas, Campinas, SP, Brazil.
    Acne is the most common skin disorder and can directly affect the patients' self-esteem. Systemic treatment has been indicated for nodular, cystic or persistent acne rather than another type of treatment, such as a topic one. Isotretinoin is an analogue of vitamin A and by suppressing the sebaceous glands the disease can be controlled. Read More

    Light therapies for acne: abridged Cochrane systematic review including GRADE assessments.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
    We undertook a Cochrane review of randomized controlled trials (RCTs) evaluating the effects of light-based interventions for acne vulgaris. We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, ISI Web of Science, and grey literature sources (September 2015). We used the Grading of Recommendations Assessment, Development and Evaluation Working Group approach to assess the quality of evidence (QE). Read More

    ALA-PDT suppressing the cell growth and reducing the lipogenesis in human SZ95 sebocytes by mTOR signaling pathway in vitro.
    Photodiagnosis Photodyn Ther 2017 Jun 19;18:295-301. Epub 2017 Mar 19.
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, PR China. Electronic address:
    Background: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, the therapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate the effects and mechanisms of ALA-PDT on the cell growth and lipogenesis of human SZ95 sebocytes. Read More

    Multiple miliary osteoma cutis of the face associated with Albright hereditary osteodystrophy in the setting of acne vulgaris: a case report.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Internal Medicine, University of Central Florida College of Medicine, Orlando Florida.
    Osteoma cutis is a condition characterized by theformation of bone within the skin. Such aberrantossification of the skin and subcutaneous tissue isconsidered primary when it arises in the absence ofunderlying tissue damage or a preceding cutaneouslesion. Conversely, secondary osteoma cutis occurswhen skin ossification is the result of a pre-existingskin lesion, trauma, or inflammatory process [1,2]. Read More

    Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects.
    J Dermatolog Treat 2017 Apr 2:1-13. Epub 2017 Apr 2.
    b Department of Dermatology , American University of Beirut , Beirut , Lebanon.
    Retinoids are a class of compounds derived from vitamin A or having structural and/or functional similarities with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. Read More

    Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the Unites States.
    J Drugs Dermatol 2017 Feb;16(2):97-102
    Although there have been few formal studies, scarring is a known bothersome companion of acne vulgaris. We performed a prospective study of subjects consulting a dermatologist for active acne to assess the frequency of acne scarring. Investigators performed a short questionnaire on all acne patients seen at their office for one consecutive 5-day work week to assess scar frequency. Read More

    Adverse effects of isotretinoin: A large, retrospective review.
    Dermatol Ther 2017 Mar 14. Epub 2017 Mar 14.
    Department of Geriatrics, Healthy Ageing Research Centre (HARC), Medical University of Lodz, Pl. Hallera 1, Lodz, 90-647, Poland.
    Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Read More

    Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Mar 11. Epub 2017 Mar 11.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. Read More

    The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.
    Am J Clin Dermatol 2017 Jun;18(3):311-321
    Department of Dermatology, University of Illinois at Chicago, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA.
    Background: Acne vulgaris is a highly prevalent skin disorder that affects almost all adolescents and can persist into adulthood. Photodynamic therapy (PDT) is an emerging treatment for acne that involves the use of a photosensitizer in combination with a light source and oxygen.

    Methods: We performed a systematic review of the literature and critically evaluated the studies. Read More

    Therapeutic approaches to reducing atrophic acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):190-194. Epub 2016 Oct 27.
    National and Kapodistrian University of Athens, Athens, Greece.
    Atrophic acne scars are a common and undesirable outcome of acne vulgaris related to both its severity and delay in treatment. Such scars can be classified according to the depth and shape of the collagen loss: ice pick, boxcar, or rolling. The presence of atrophic acne scars can compromise the self-esteem and psychologic well-being of patients, creating a challenge for both the patient and the dermatologist. Read More

    Laser and light-based treatments of acne and acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):183-189. Epub 2016 Oct 27.
    Dermatology and Laser Surgery Center, Yale University School of Medicine, New York, New York , 955 Park Avenue, New York, NY 10028. Electronic address:
    The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy. Read More

    Objective assessment of acne.
    Clin Dermatol 2017 Mar - Apr;35(2):147-155. Epub 2016 Oct 27.
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
    A precise and reliable assessment of acne severity is unarguably the most essential clinical method when it comes to monitoring and choosing optimal treatment in the daily practice. Since the early 1960s, different severity assessment systems have been described in the literature. The two commonly used concepts are global gradings and lesion counting. Read More

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