12,140 results match your criteria Acne Vulgaris


Platelet-Rich Plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group. School of Science, Antonio Nariño University, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia and skin ulcers. Read More

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http://dx.doi.org/10.1002/term.2832DOI Listing
February 2019

Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts.

J Dermatol Sci 2019 Jan 26. Epub 2019 Jan 26.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan. Electronic address:

Background: The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2019.01.007DOI Listing
January 2019

A Novel Combined Light-Based Treatment of Acne Vulgaris With 1,450-nm Diode Laser and 450-nm Blue Light.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Background: Nonablative 1,450-nm diode laser (DL) and visible blue light (BL) have been effectively used for acne with superior safety profiles.

Objective: To evaluate synergistic effects of sequential DL and BL application for acne.

Methods: A 20-week, randomized split-face study was conducted to compare clinical courses between 2 facial sides either receiving sequential application of DL and BL or BL alone in 24 patients with mild to moderate facial acne vulgaris. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001815DOI Listing
February 2019

Dermatologic Surgical Care for Transgender Individuals.

Dermatol Surg 2019 Feb 14. Epub 2019 Feb 14.

George Washington University School of Medicine and Health Sciences, Washington, DC.

Background: Transgender individuals experience common and unique dermatologic concerns from severe acne associated with testosterone therapy in transmen to complications due to illicit silicone injections in transwomen. Currently, 2 survey studies and 4 reviews have addressed the dermatologic care of transgender individuals. However, none of them provide a focus on the dermatologic surgeon. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001718DOI Listing
February 2019

Antibiotic susceptibility of isolated from patients with acne in a public hospital in Southwest China: prospective cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e022938. Epub 2019 Feb 19.

Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, China.

Objective: Antibiotics have been routinely used for several decades against (), but antibiotic resistance of is becoming a global problem. Only one related Chinese study is available. The aim of this study was to assess the antibiotic susceptibility of obtained from patients with acne in Southwest China. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022938DOI Listing
February 2019

Second joint position paper: Use of isotretinoin in severe acne

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):441-446. Epub 2019 Jan 28.

SPRIM Américas México, Gerencia de Investigación Clínica. Ciudad de México, México

Background: The use of isotretinoin is indicated in the treatment of severe acne; however, its adverse effects are important.

Objective: To update the first Mexican Consensus on the use of isotretinoin in severe acne vulgaris, which took place in 2009.

Methods: It was carried out a literature search between June 2009, and February 2015, in order to evaluate topics to be discussed; materials were sent to the experts to promote the debate among participants. Read More

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January 2019

Role of 11β HSD 1, rs12086634, and rs846910 single-nucleotide polymorphisms in metabolic-related skin diseases: a clinical, biochemical, and genetic study.

Clin Cosmet Investig Dermatol 2019 23;12:91-102. Epub 2019 Jan 23.

Department of Chemistry, Biochemistry Division, Faculty of Science, Menoufia University, Shibin El Kom, Egypt.

Background: 11β HSD1 generates cortisol from cortisone. 11β HSD1 single-nucleotide polymorphism (SNP) was associated with metabolic syndrome (MeTS). Although the relation of acne vulgaris (AV) and skin tags (STs) with MeTS has been reported, the relationship between 11β HSD 1 SNP and cortisol activity in those patients has not studied till now. Read More

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http://dx.doi.org/10.2147/CCID.S193156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350638PMC
January 2019

The effect of isotretinoin on insulin resistance and adipocytokine levels in acne vulgaris patients

Turk J Med Sci 2019 Feb 11;49(1):238-244. Epub 2019 Feb 11.

Background/aim: Recent data draw attention to the effect of body composition, insulin resistance, and adipocytokines to acne vulgaris (AV) development. The aim of this study was to assess the association of AV with insulin resistance and adipocytokine levels and to evaluate the effect of isotretinoin on insulin resistance and adipocytokine levels.

Materials And Methods: In 29 AV patients and 29 healthy volunteers, body mass index (BMI) and body fat mass (BFM), lipid, adiponectin, leptin, resistin, retinol binding protein-4 (RBP4), and insulin levels were measured and insulin resistance was assessed by HOMA-IR index in serum samples taken twice from patients before and after isotretinoin treatment. Read More

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http://dx.doi.org/10.3906/sag-1806-44DOI Listing
February 2019

Association of Systemic Antibiotic Treatment of Acne With Skin Microbiota Characteristics.

JAMA Dermatol 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Johns Hopkins School of Medicine, Baltimore, Maryland.

Importance: Given the widespread use of systemic antibiotics for treatment of moderate to severe acne, it is important to understand the associations of such antibiotic use with changes not only in Cutibacterium acnes (formerly Propionibacterium acnes) but also in the complete bacterial community of the skin.

Objective: To examine the composition, diversity, and resilience of skin microbiota associated with systemic antibiotic perturbation in individuals with acne.

Design, Setting, And Participants: This longitudinal cohort study conducted at an academic referral center in Maryland from February 11 to September 23, 2014, included 4 female participants who had received a recent diagnosis of acne vulgaris, showed comedonal and inflammatory acne on the face, were at least 18 years old, and had no recent use of systemic or topical treatments for acne, including antibiotics and retinoids. Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5221DOI Listing
February 2019
7 Reads

Microneedling Therapy for Atrophic Acne Scar: Effectiveness and Safety in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 29;7(2):293-297. Epub 2019 Jan 29.

University of Rome G. Marconi, Rome, Italy.

Aim: To evaluate the effectiveness and safety of micro-needling therapy in atrophic acne scar treatment.

Method: A prospective, single centred study was implemented in a total of 31 patients suffering from atrophic acne scar grade 2 to 4 of Goodman and Baron scaring grading system was recruited. They were treated by microneedle derma roller every week in 3 months. Read More

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http://dx.doi.org/10.3889/oamjms.2019.098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364723PMC
January 2019

Efficacy of Oral Low-Dose Isotretinoin in the Treatment of Acne Vulgaris in Vietnam.

Open Access Maced J Med Sci 2019 Jan 20;7(2):279-282. Epub 2019 Jan 20.

University of Rome G. Marconi, Rome, Italy.

Background: Oral isotretinoin is an effective therapy for acne. However, isotretinoin can induce hyperhomocysteinemia and decreased serum folic acid level, which may be a risk for cardiovascular disease and thrombosis, as well as psychoses. Besides, many recent types of research emphasise the safety and effects of the low dose isotretinoin therapy. Read More

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http://dx.doi.org/10.3889/oamjms.2019.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364726PMC
January 2019

Efficacy of Oral Isotretinoin in Combination with Desloratadine in the Treatment of Common Vulgaris Acne in Vietnamese Patients.

Open Access Maced J Med Sci 2019 Jan 25;7(2):217-220. Epub 2019 Jan 25.

University of Rome G. Marconi, Rome, Italy.

Aim: To evaluate the efficacy of oral isotretinoin used alone and in combination with desloratadine in the treatment of moderate acne vulgaris.

Methods: A comparative clinical trial was undertaken to evaluate the efficacy of oral isotretinoin alone and in combination with desloratadine in the treatment of 62 moderate acne vulgaris patients. Patients were randomised into two groups with 31 patients in each group. Read More

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http://dx.doi.org/10.3889/oamjms.2019.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364732PMC
January 2019

Short-Chain Fatty Acids from Activate Both a Canonical and Epigenetic Inflammatory Response in Human Sebocytes.

J Immunol 2019 Feb 8. Epub 2019 Feb 8.

Department of Dermatology, University of California, San Diego, La Jolla, CA 92093; and

The regulation of cutaneous inflammatory processes is essential for the human skin to maintain homeostasis in the presence of the dense communities of resident microbes that normally populate this organ. Forming the hair follicle-associated sebaceous gland, sebocytes are specialized lipid-producing cells that can release inflammatory mediators. Cytokine and chemokine expression by pilosebaceous epithelial cells (i. Read More

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http://dx.doi.org/10.4049/jimmunol.1800893DOI Listing
February 2019
1 Read

Insights on an in vivo model for postinflammatory hyperpigmentation.

Br J Dermatol 2019 Feb 6. Epub 2019 Feb 6.

Department of Dermatology, Henry Ford Hospital, Detroit, MI.

Postinflammatory hyperpigmentation (PIH) can occur following a multitude of inflammatory skin conditions including acne vulgaris. It is more common in darker Fitzpatrick phototypes and represents a common skin complaint in dermatology offices. Despite its common occurrence, treatment options for PIH remain limited. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17746
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http://dx.doi.org/10.1111/bjd.17746DOI Listing
February 2019
4 Reads

Minocycline-induced transient depersonalization: A case report.

SAGE Open Med Case Rep 2019 17;7:2050313X18823827. Epub 2019 Jan 17.

Division of Dermatology, McGill University, Montreal, QC, Canada.

Minocycline is a medication commonly used for the treatment of acne vulgaris. The central nervous system-induced side effects of minocycline include headaches, pseudotumor cerebri, ataxia, and vestibular dysfunction. Many minocycline-related side effects have been presented in the literature, however, reports of depersonalization symptoms induced by the medication are rare. Read More

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http://dx.doi.org/10.1177/2050313X18823827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349971PMC
January 2019
1 Read

Is there an association between isotretinoin therapy and adverse mood changes? A prospective study in a cohort of acne patients.

J Dermatolog Treat 2019 Feb 5:1-6. Epub 2019 Feb 5.

c Kinghorn Dermatology Unit , Royal United Hospital , Bath , UK.

Background: Treatment with isotretinoin has been associated with adverse mood changes. However, even though a number of studies support this association, others refute it, and a concrete causal link has yet to be proven. Acne itself is associated with depressive symptoms, thus making studies on the topic difficult to design and interpret. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577545DOI Listing
February 2019

Over-the-counter light therapy for acne: a cross-sectional retrospective analysis.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

Case Western Reserve University School of Medicine, Cleveland.

Acne vulgaris affects a large portion of the population and drives many patients to seek over-the-counter (OTC) treatments. Light-emitting diode (LED) therapy has recently emerged as a potential therapeutic option for inflammatory acne. We used the U. Read More

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January 2019
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Studying the efficacy of a new radical treatment for acne vulgaris using a surgical technique.

J Dermatolog Treat 2019 Feb 1:1-21. Epub 2019 Feb 1.

b Department of Plastic Reconstructive Surgery , Yamate Clinic , Kiguchi Bldg. 5F, 1-4-4 Sannomiyacho, Chuo-ku , Kobe-shi , Hyogo 650-0021 , Japan.

Background: Despite the numerous treatments available for acne vulgaris, not all are efficacious, and many patients experience psychological distress and various side effects from medications used to treat this condition. The objective of this study was to develop a new surgical technique for the treatment of acne.

Methods: This surgical technique utilizes tweezers to widen the hair follicle to discharge comedo and pus completely and quickly from the acne. Read More

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http://dx.doi.org/10.1080/09546634.2019.1577948DOI Listing
February 2019

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample.

Clin Exp Dermatol 2019 Jan 31. Epub 2019 Jan 31.

Departments of Dermatology, Preventative Medicine, and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Little is known about the mental health (MH) hospitalization among patients with acne and rosacea.

Aims: To determine the MH disorders and cost burden associated with acne and rosacea.

Methods: Data were examined from the 2002-2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions). Read More

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http://dx.doi.org/10.1111/ced.13919DOI Listing
January 2019
1 Read

Clinical efficacy of 0.5% topical mangosteen extract in nanoparticle loaded gel in treatment of mild-to-moderate acne vulgaris: A 12-week, split-face, double-blinded, randomized, controlled trial.

J Cosmet Dermatol 2019 Jan 27. Epub 2019 Jan 27.

Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.

Background: Acne vulgaris is the most common inflammatory sebaceous gland disorder in young adults. The resistant strains of Propionibacterium acnes (P. acnes) are of increasing concern in the treatment of acne. Read More

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http://dx.doi.org/10.1111/jocd.12856DOI Listing
January 2019
1 Read

Novel Tretinoin 0.05% Lotion for Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris in a Hispanic Population

J Drugs Dermatol 2019 01;18(1):32-38

Background: Acne vulgaris (acne) is the most common dermatologic disease seen in a racially, geographically, politically, culturally, and socioeconomically diverse Hispanic population. Despite their growing demographics in the US, there are few studies evaluating acne treatment in this population. Potential for skin irritation and dryness, as well as pigmentary changes are key concerns. Read More

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January 2019
1 Read

Survivin and insulin-like growth factor-I: potential role in the pathogenesis of acne and post-acne scar.

Scars Burn Heal 2019 Jan-Dec;5:2059513118818031. Epub 2019 Jan 10.

Faculty of Medicine, Fayoum University, Fayoum, Egypt.

Backgrounds/objectives: Acne is an inflammatory disease of the pilosebaceous unit (PSU). The over-expression of survivin and insulin-like growth factor (IGF)-I in some fibrotic disorders suggests a possible implication in the pathogenesis of acne and or post-acne scar. We aimed to evaluate their potential role in pathogenesis in acne and post-acne scar. Read More

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http://dx.doi.org/10.1177/2059513118818031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330724PMC
January 2019

Models for acne: A comprehensive study.

Drug Discov Ther 2018 ;12(6):329-340

Department of Pharmaceutical Sciences, Dr. Harisingh Gour University.

Acne vulgaris (AV) is the familiar chronic skin ailment affecting most of the individuals. This multifarious, disease involves the bacterium gram-positive, anaerobic Propionibacterium acnes (P. acnes) which resides on skin microflora, and participated in acne inflammation and acne lesions. Read More

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http://dx.doi.org/10.5582/ddt.2018.01079DOI Listing
January 2018

Topical Retinoids in Acne Vulgaris: A Systematic Review.

Am J Clin Dermatol 2019 Jan 23. Epub 2019 Jan 23.

Department of Dermatology, Center for Dermatology Research, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157-1071, USA.

Background: Topical retinoids are a first-line treatment for acne vulgaris.

Objective: This systematic review aims to evaluate the efficacy, safety, and tolerability of topical retinoids approved in the United States for the treatment of acne vulgaris.

Methods: A PubMed and Embase search was conducted using the search terms 'adapalene,' 'tretinoin,' 'tazarotene,' and 'acne vulgaris. Read More

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http://link.springer.com/10.1007/s40257-019-00423-z
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http://dx.doi.org/10.1007/s40257-019-00423-zDOI Listing
January 2019
3 Reads

Sarecycline: First Global Approval.

Authors:
Emma D Deeks

Drugs 2019 Jan 18. Epub 2019 Jan 18.

Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Sarecycline (Seysara™) is an oral, once-daily, tetracycline-class drug for which a tablet formulation is approved in the USA for the treatment of inflammatory lesions of non-nodular moderate to severe acne vulgaris in patients aged ≥ 9 years. The drug was developed by Paratek and Allergen and later acquired by Almirall S.A. Read More

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http://dx.doi.org/10.1007/s40265-019-1053-4DOI Listing
January 2019

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris in a preadolescent population.

Pediatr Dermatol 2019 Jan 18. Epub 2019 Jan 18.

Dow Pharmaceutical Sciences Inc., Petaluma, California.

Background: Acne vulgaris (acne) is a common skin condition in children and adolescents. Efficacy of tretinoin is well documented in studies that included pediatric patients (12-18 years of age). With acne routinely presenting in younger patients, data are needed in this important group. Read More

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http://dx.doi.org/10.1111/pde.13744DOI Listing
January 2019

Association of interleukin-6 gene promoter polymorphism with acne vulgaris and its severity.

Clin Exp Dermatol 2019 Jan 16. Epub 2019 Jan 16.

Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Background: Acne vulgaris (AV) is an inflammatory disorder with a possible genetic background. Different cytokines and mediators are involved in its pathogenesis.

Aim: Our aim was to investigate the interleukin (IL)-6 572 polymorphism in patients with AV and its relation to patient sex and acne severity. Read More

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http://dx.doi.org/10.1111/ced.13864DOI Listing
January 2019
1 Read

Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action.

Br J Pharmacol 2019 Jan 14. Epub 2019 Jan 14.

Group of peptides and natural products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, P.R. China.

Background And Purpose: Propionibacterium acnes (P. acnes) is a Gram-positive bacterium associated with the skin disorder acne. In this study, considering the importance of fatty acids in the life habitat of P. Read More

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http://dx.doi.org/10.1111/bph.14571DOI Listing
January 2019
2 Reads

[Advancement in phodynamic therapy for non-neoplastic skin diseases].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Dec;43(12):1380-1383

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.

Photodynamic therapy is mainly used in dermatology to treat skin tumors, precancerous lesions, and condyloma acuminatum. Due to its excellent tissue selectivity, easy operation and good cosmetic effect, it has been gradually applied to the treatment of various non-neoplastic skin diseases, such as verruca acuminata, acne, rosacea, chronic skin ulcer, fungal diseases, keloid, and so on. Here is the review on the advancement in photodynamic therapy for non-neoplastic skin diseases. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2018.12.016DOI Listing
December 2018
1 Read

Acne, the Skin Microbiome, and Antibiotic Treatment.

Am J Clin Dermatol 2019 Jan 10. Epub 2019 Jan 10.

Department of Molecular and Medical Pharmacology, Crump Institute for Molecular Imaging, David Geffen School of Medicine, University of California, Los Angeles, 4339 CNSI, 570 Westwood Plaza, Building 114, Los Angeles, CA, 90095, USA.

Acne vulgaris is a chronic skin disorder involving hair follicles and sebaceous glands. Multiple factors contribute to the disease, including skin microbes. The skin microbiome in the follicle is composed of a diverse group of microorganisms. Read More

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http://link.springer.com/10.1007/s40257-018-00417-3
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http://dx.doi.org/10.1007/s40257-018-00417-3DOI Listing
January 2019
8 Reads

Acne Vulgaris.

Authors:
Fei Han

N Engl J Med 2019 01;380(2):199

Suqian First Hospital, Suqian, China

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http://dx.doi.org/10.1056/NEJMc1814789DOI Listing
January 2019

Acne Vulgaris.

N Engl J Med 2019 01;380(2):199-200

Penn State Hershey Medical Center, Hershey, PA

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http://dx.doi.org/10.1056/NEJMc1814789DOI Listing
January 2019

Metabolic syndrome in dermatology: Treatment and Management for Dermatologists.

Dermatol Ther 2019 Jan 8:e12812. Epub 2019 Jan 8.

Department of Dermatology and Venerology, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkey.

Metabolic syndrome, a commonly observed pathology and a global health issue, is closely related to the skin and thus dermatologists. The skin contributes to the development of metabolic syndrome and it is an end organ for it. Metabolic dysfunction is related to many skin disorders, some of which with high association and some of which with lower association. Read More

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http://doi.wiley.com/10.1111/dth.12812
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http://dx.doi.org/10.1111/dth.12812DOI Listing
January 2019
3 Reads

Abnormal plasma lipids profile in women with post-adolescent acne.

Postepy Dermatol Alergol 2018 Dec 13;35(6):605-608. Epub 2018 Nov 13.

Department of Cosmetology and Esthetic Dermatology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.

Introduction: Acne vulgaris is a multifactorial chronic inflammatory disease that is increasingly recognized in adult women.

Aim: To investigate a relationship between plasma lipids profile and acne in women and a correlation between selected clinical features of acne (severity, age of onset, location of lesions and the presence of comedones) and lipids profile.

Material And Methods: Sixty-four adult women with post-adolescent acne and 20 healthy controls were included in the study. Read More

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http://dx.doi.org/10.5114/ada.2018.77612DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320488PMC
December 2018

Topical application of phenolic compounds suppresses Propionibacterium acnes-induced inflammatory responses in mice with ear edema.

Naunyn Schmiedebergs Arch Pharmacol 2019 Jan 7. Epub 2019 Jan 7.

Programa de Pós-Graduação em Ciência e Biotecnologia, Universidade do Oeste de Santa Catarina - UNOESC, Campus Videira, Rua Paese 180, Videira, SC, 89560-000, Brazil.

Acne vulgaris (AV), a severe chronic inflammatory dermatosis, commonly treated with systemic or topical antibiotics that exacerbate bacterial resistance and pose adverse side effects, new approaches for suppressing or reducing Propionibacterium acnes-induced inflammatory responses and thereby treating AV remain necessary. In response, the goal of our study was to investigate the therapeutic potential of phenolic compounds in the in vivo inflammatory process induced by P. acnes. Read More

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http://dx.doi.org/10.1007/s00210-018-01604-zDOI Listing
January 2019
1 Read

A review of the FDA's 510(k) approvals process for electromagnetic devices used in body contouring.

J Dermatolog Treat 2019 Jan 7:1-9. Epub 2019 Jan 7.

c Department of Dermatology , University Hospitals Cleveland Medical Center , USA.

Introduction: Greater demand for noninvasive techniques to reduce cellulite and contour the body have led to the growth of electromagnetic and radiofrequency devices. In this study, we aimed to characterize the evolution and safety of electromagnetic devices marketed in the U.S. Read More

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http://dx.doi.org/10.1080/09546634.2019.1566589DOI Listing
January 2019
13 Reads

Adipose Stem Cells with Conditioned Media for Treatment of Acne Vulgaris Scar.

Tissue Eng Regen Med 2018 Feb 16;15(1):49-61. Epub 2018 Jan 16.

1Department of Plastic and Reconstructive Surgery, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591 Republic of Korea.

This study was to investigate the effect of subcutaneous injection of the adipose stem cells (ASCs) with conditioned media (CM) in the treatment of acne vulgaris scar. We used Adult male New Zealand white rabbit ears as an animal model and induced acne formation by Kignman method. Adipose tissue was isolated and harvested from the scapula of rabbits, and ASCs were cultured and expanded until passage 1. Read More

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http://link.springer.com/10.1007/s13770-017-0105-7
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http://dx.doi.org/10.1007/s13770-017-0105-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171636PMC
February 2018
13 Reads

BPX-01 Minocycline Topical Gel Shows Promise for the Treatment of Moderate-to-severe Inflammatory Acne Vulgaris.

J Clin Aesthet Dermatol 2018 Nov 1;11(11):25-35. Epub 2018 Nov 1.

Dr. Alexis is with Mount Sinai St. Luke's in New York, New York.

Acne vulgaris is a highly prevalent and multifactorial skin disorder that can adversely impact health-related quality of life. Factors that contribute to the pathogenesis of acne include pilosebaceous proliferation of proinflammatory () bacteria, presence of circulating androgens, excess sebum production, abnormal follicular keratinization, and multiple inflammatory cascades. Oral tetracyclines-especially doxycycline and minocycline-are frequently prescribed for the treatment of moderate-to-severe acne, given their anti-inflammatory properties and their effect on reduction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303111PMC
November 2018
1 Read

Treatment of acne with a combination of propolis, tea tree oil, and compared to erythromycin cream: two double-blind investigations.

Clin Pharmacol 2018 13;10:175-181. Epub 2018 Dec 13.

Skinlab, Department of Biomedical Sciences, University of Sassari, Sassari, Italy,

Introduction: Antibiotics that suppress are the standard treatment for acne but are becoming less effective, due to the appearance of antibiotic-resistant strains. Many plants are known to have innate antimicrobial action and can be used as alternatives to antibiotics; thus, it is necessary to prove their effectiveness in vivo. This study aimed to evaluate the anti-acne efficacy of a new cream based on three natural extracts, comparing it to erythromycin cream and placebo. Read More

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https://www.dovepress.com/treatment-of-acne-with-a-combinati
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http://dx.doi.org/10.2147/CPAA.S180474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6298394PMC
December 2018
5 Reads

Retinoids in Acne Management: Review of Current Understanding, Future Considerations, and Focus on Topical Treatments

Authors:
Anna Chien

J Drugs Dermatol 2018 Dec;17(12):s51-55

Acne vulgaris is the most common skin condition affecting adolescents and young adults with a tremendous psychosocial impact. Its pathogenic hallmarks include follicular dyskeratosis, increased sebum production, and inflammation induced by Cutibacterium (formerly Propionibacterium) acnes within the follicle. Retinoids, derived from vitamin A, are the mainstays of acne treatment given they address the key pathogenic pathways of acne. Read More

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December 2018
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Retinoids in Acne Management: Review of Current Understanding, Future Considerations, and Focus on Topical Treatments

Authors:
Anna Chien

J Drugs Dermatol 2018 Dec;17(12):s51-55

Acne vulgaris is the most common skin condition affecting adolescents and young adults with a tremendous psychosocial impact. Its pathogenic hallmarks include follicular dyskeratosis, increased sebum production, and inflammation induced by Cutibacterium (formerly Propionibacterium) acnes within the follicle. Retinoids, derived from vitamin A, are the mainstays of acne treatment given they address the key pathogenic pathways of acne. Read More

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December 2018
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Evaluation, Prevention, and Management of Acne Scars: Issues, Strategies, and Enhanced Outcomes

J Drugs Dermatol 2018 Dec;17(12):s44-48

Acne is a common disease affecting a high percentage of the younger population. Without appropriate and effective primary prevention of scarring, post-acne scars occur in about 80-95% of all patients. Acne scarring is the result of an alteration of the healing process and it can have deep psychosocial implications for patients. Read More

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December 2018
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Acne and Scarring: Facing the Issue to Optimize Outcomes

Authors:
Jerry Tan

J Drugs Dermatol 2018 Dec;17(12):s43

This supplement summarize recent advances in the scientific understanding of acne pathogenesis as it relates to effective treatment acne in patients of all skin types and describes the role of retinoids in the management of acne and effective treatment and prevention strategies for hypertrophic and atrophic acne scarring in all skin types. Read More

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December 2018
4 Reads

A Microtube Array Membrane (MTAM) Encapsulated Live Fermenting Staphylococcus epidermidis as a Skin Probiotic Patch against Cutibacterium acnes.

Int J Mol Sci 2018 Dec 20;20(1). Epub 2018 Dec 20.

Department of Biomedical Sciences and Engineering, National Central University, Taoyuan 32001, Taiwan.

Antibiotics without selectivity for acne treatment may destroy the beneficial microbes in the human microbiome that helps to fight Cutibacterium acnes (C. acnes), a bacterium associated with inflammatory acne vulgaris. Probiotic treatment by direct application of live () onto the open acne lesions may run the risk of bloodstream infections. Read More

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http://dx.doi.org/10.3390/ijms20010014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337527PMC
December 2018
4 Reads

Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.

Nat Commun 2018 12 12;9(1):5075. Epub 2018 Dec 12.

Department of Medical and Molecular Genetics, School of Basic & Medical Biosciences, King's College London, London, SE1 9RT, UK.

Acne vulgaris is a highly heritable common, chronic inflammatory disease of the skin for which five genetic risk loci have so far been identified. Here, we perform a genome-wide association study of 3823 cases and 16,144 controls followed by meta-analysis with summary statistics from a previous study, with a total sample size of 26,722. We identify 20 independent association signals at 15 risk loci, 12 of which have not been previously implicated in the disease. Read More

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http://dx.doi.org/10.1038/s41467-018-07459-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290788PMC
December 2018
2 Reads

Propionibacterium (Cutibacterium) acnes Bacteriophage Therapy in Acne: Current Evidence and Future Perspectives.

Dermatol Ther (Heidelb) 2019 Mar 11;9(1):19-31. Epub 2018 Dec 11.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.

Acne vulgaris is the most common dermatological disorder worldwide. It is a multifactorial disease that involves increased sebum production, hyperkeratinization of the pilosebaceous unit, Propionibacterium acnes (Cutibacterium acnes) colonization, and inflammation. The human skin microbiome hosts a wide variety of microorganisms, including bacteria, viruses, and fungi. Read More

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http://dx.doi.org/10.1007/s13555-018-0275-9DOI Listing
March 2019
3 Reads

Draft Genome Sequence of Propionibacterium acnes subsp. elongatum Strain Asn12.

Microbiol Resour Announc 2018 Jul 19;7(2). Epub 2018 Jul 19.

Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Szeged, Hungary.

Propionibacterium acnes, a non-spore-forming anaerobic Gram-positive bacterium, has been linked to a wide range of opportunistic human infections and conditions, most notably acne vulgaris. Here, we present the draft genome sequence of P. acnes subsp. Read More

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http://dx.doi.org/10.1128/MRA.00801-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211360PMC

Expression of Three Adipokines (Adiponectin, Leptin and Resistin) in Normal Canine Skin: a Pilot Study.

J Comp Pathol 2018 Nov 28. Epub 2018 Nov 28.

Dermatology/Parasitology/Mycology Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes, France; NP3 Unit, School of Veterinary Medicine-ONIRIS, University of Nantes, CS 40706, Nantes 44307, France. Electronic address:

Adipokines are biologically active cytokines that are mainly produced in adipose tissue. There is evidence, in man and mice, that some adipokines may be secreted in other tissues including the vascular endothelium, epithelia and sebaceous glands. Moreover, modified serum levels of adipokines have been detected in people with acne vulgaris or psoriasis; it is suspected that adipokines could contribute to local and systemic inflammatory conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219975183027
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http://dx.doi.org/10.1016/j.jcpa.2018.10.179DOI Listing
November 2018
16 Reads

Enhanced skin targeting of retinoic acid spanlastics: in vitro characterization and clinical evaluation in acne patients.

J Liposome Res 2019 Feb 5:1-8. Epub 2019 Feb 5.

c Department of Dermatology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Acne vulgaris is the most common dermatological disorder affecting millions of individuals. Acne therapeutic solutions include topical treatment with retinoic acid (RA) which showed a good efficacy in treatment of mild and moderate cases. However, the high prevalence of adverse events, such as skin dryness, shedding and skin irritation affects the patient convenience and obstruct the acne treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/08982104.2018.1
Publisher Site
http://dx.doi.org/10.1080/08982104.2018.1552706DOI Listing
February 2019
11 Reads