12,222 results match your criteria Acne Vulgaris


Nonvascular uses of pulsed dye laser in clinical dermatology.

J Cosmet Dermatol 2019 Apr 19. Epub 2019 Apr 19.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.

Lasers are fast becoming the vogue of dermatology ranging from ablative, nonablative, fractional photothermolysis to vascular lasers. There are a range of vascular lasers including potassium titanyl phosphate (KTP 532 nm), pulsed dye laser (PDL -595 nm), diode (810 nm), and Nd:YAG (1064 nm). PDL is a laser that emits yellow light using Rhodamine dye as it is lasing medium. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12924DOI Listing

Clinical assessment of topical erythromycin gel with and without zinc acetate for treating mild to moderate acne vulgaris.

J Dermatolog Treat 2019 Apr 18:1-23. Epub 2019 Apr 18.

b Department of Dermatology , School of Medicine, Shiraz University of Medical Sciences , Shiraz , Iran.

Erythromycin is an effective topical antibiotic for treating mild to moderate inflammatory acne vulgaris, especially papules acne during puberty as well as papules - pustular acne in adult women. Erythromycin is a macrolide antibiotic that has long been used as a topical dosage form to treat acne. It has favorable effects in resolving inflammatory acne lesions not only by reducing Propioni bacterium acnes density, but also by directly inhibiting neutrophil chemotactic factors and reactive oxygen species (ROS) production (1- 3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1606394DOI Listing

A curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager.

Authors:
Sergio U Dani

Swiss Med Wkly 2019 Apr 17;149:w20071. Epub 2019 Apr 17.

Medawar Institute for Medical and Environmental Research, Acangau Foundation, Paracatu, MG, Brazil, and PizolCare Praxis Sargans, Switzerland.

Arsenic is a toxicant that has no dose threshold below which exposures are not harmful. Here I report a curious association of chronic homeopathic arsenic ingestion with nonspecific symptoms in a Swiss teenager. For about 4 years she had taken globules of a freely purchasable homeopathic remedy containing inorganic arsenic (iAs), infinitesimally diluted to D6 (average arsenic content per single globule: 0. Read More

View Article

Download full-text PDF

Source
https://doi.emh.ch/smw.2019.20071
Publisher Site
http://dx.doi.org/10.4414/smw.2019.20071DOI Listing
April 2019
2 Reads

Treatment of Moderate-to-severe Facial Acne Vulgaris with Solid-state Fractional 589/1,319-nm Laser.

J Clin Aesthet Dermatol 2019 Mar 1;12(3):28-31. Epub 2019 Mar 1.

Drs. Kang and Herrmann are with the Division of Dermatology, Harbor-UCLA Medical Center in Torrance, California.

The objectives of this study were to evaluate the efficacy, safety and patient satisfaction of a unique combination of wavelengths 589nm and 1,319nm for the treatment of facial acne vulgaris. This was a small, randomized, prospective, split-face, single-blinded study of patients with moderate-to-severe acne vulgaris. The study took place at a single outpatient center study in Torrance, California. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440707PMC

Facial cleansing with a sonic brush-A review of the literature and current recommendations.

J Cosmet Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, University of Miami, Miller School of Medicine, Miami, Florida.

Introduction: Skin cleansing is important for removal of dirt, debris, and sebum and plays an important role in reduction of pollution-induced skin aging. Cleansing is an established part of treatment recommendations and procedures in dermatology. Different methods for facial skin cleansing are established but recommendations on use of special devices are not fully integrated into clinical practice. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/jocd.12906
Publisher Site
http://dx.doi.org/10.1111/jocd.12906DOI Listing
April 2019
3 Reads

The Effects of Isotretinoin on Affective and Cognitive Functions are Disparate in Adolescent Acne Vulgaris Patients.

J Dermatolog Treat 2019 Apr 15:1-17. Epub 2019 Apr 15.

b Department of Child and Adolescent Psychiatry , Ankara University, School of Medicine , Ankara , Turkey.

Background: The vulnerable brain regions to isotretinoin are represented as hippocampus and prefrontal cortex, involved in mood regulation as well as coordination of cognitive functions. Adolescence is a critical period with dynamic alterations in neurocognition. Isotretinoin brought concerns about its possible effects on executive functions, attention and memory. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1606396DOI Listing

Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations.

Aims: The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12940DOI Listing
April 2019
5 Reads

Prevalence of cutaneous comorbidities in psoriatic patients and their impact on quality of life.

Eur J Dermatol 2019 Apr 10. Epub 2019 Apr 10.

Dermatology Department, Catholic University of the Sacred Heart, Rome.

In contrast to the evidence for systemic co-morbidities, relatively few studies have examined the prevalence of cutaneous inflammatory co-morbidities in psoriatic patients. We conducted an observational multi-site study to measure the prevalence of cutaneous co-morbidities in adult patients with plaque psoriasis and to assess the relative impact on quality of life (QOL). Each patient attending one of the study clinics over a period of six months was evaluated to assess the presence of any concomitant skin inflammatory disease other than psoriasis at the time of the visit. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1684/ejd.2019.3529DOI Listing
April 2019
2 Reads

Salicylic acid treats acne vulgaris by suppressing AMPK/SREBP1 pathway in sebocytes.

Exp Dermatol 2019 Apr 11. Epub 2019 Apr 11.

Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, P. R. China.

Acne vulgaris is a prevalent cutaneous disease characterized by a multifactorial pathogenic process including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes as well as Propionibacterium acnes (P. acnes) overgrowth. Salicylic acid (SA), a beta-hydroxy acid, is frequently used in the treatment of acne. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/exd.13934DOI Listing
April 2019
3 Reads

Serum interleukin-17 as a novel biomarker in patients with acne vulgaris.

J Cosmet Dermatol 2019 Apr 9. Epub 2019 Apr 9.

Department of Medical Biochemistry, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Acne vulgaris is a common chronic inflammatory skin disease involving pilosebaceous units. Both innate and adaptive immunity, especially the T helper 17 pathway, may contribute to the inflammatory response in acne.

Objectives: We aimed at evaluation of serum interleukin-17 (IL-17) level in patients with acne vulgaris in order to assess its role in disease pathogenesis and its clinical significance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12934DOI Listing

Association between circulating adipokines and acne vulgaris: A systematic review and meta-analysis.

Australas J Dermatol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ajd.13035DOI Listing
April 2019
0.982 Impact Factor

Treatment of the facial basal cell carcinoma with the use of photodynamic therapy: A case report.

Dent Med Probl 2019 Jan-Mar;56(1):105-110

Department of Oral Surgery, Faculty of Dentistry, Wrocław Medical University, Poland.

Basal cell carcinoma (BCC) is the most common skin cancer. It accounts for approx. 80% of human skin cancers and belongs to the group of non-melanoma skin cancers (NMSC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17219/dmp/100507DOI Listing
April 2019
1 Read

Quality-of-Life Research in Acne Vulgaris: Current Status and Future Directions.

Am J Clin Dermatol 2019 Apr 4. Epub 2019 Apr 4.

Department of Psychology, University of Zaragoza, C/Pedro Cerbuna 12, 50009, Saragossa, Spain.

Acne patients may have significant quality-of-life (QoL) impairment, therefore assessment of health-related QoL (HRQoL) in acne patients is recommended by several national and international guidelines as an integral part of acne management. The inclusion of QoL assessment in core outcome sets is now a popular idea. Several acne-specific QoL questionnaires are available but none cover all topics presented in other instruments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40257-019-00438-6DOI Listing
April 2019
1 Read

Review on Characteristics and Analytical Methods of Tazarotene: An Update.

Crit Rev Anal Chem 2019 Apr 3:1-7. Epub 2019 Apr 3.

a School of Pharmacy and Technology Management , NMIMS , Shirpur , Maharashtra , India.

Tazarotene (TZR) is the first topical receptor-selective retinoid prodrug derived from vitamin A used for management of plaque psoriasis and efficacious in dealing of acne vulgaris, and photo aging. As per US food and drug administration (FDA), 0.1% strength of TZR is permitted for the treatment of acne. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10408347.2019.1586519DOI Listing
April 2019
3 Reads

Evaluation of Toll-like receptor expression profile in patients with psoriasis vulgaris.

Gene 2019 Mar 29;702:166-170. Epub 2019 Mar 29.

Department of Medical Biology, Bozok University School of Medicine, Yozgat, Turkey. Electronic address:

TLRs are thought to play a role in the pathophysiology of such dermatological diseases as leprosy, acne and psoriasis. The study included 20 patients with plaque psoriasis, as well as 20 healthy age- and gender-matched control subjects. Real-time polymerase chain reaction evaluation was made of the messenger RNA expression of TLRs 1-10 in lesional tissue and peripheral blood mononuclear cell samples in psoriasis patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gene.2019.03.058DOI Listing
March 2019
5 Reads

Novel tretinoin 0.05% lotion for the once-daily treatment of moderate-to-severe acne vulgaris: assessment of safety and tolerability in subgroups.

J Dermatolog Treat 2019 Apr 2:1-8. Epub 2019 Apr 2.

e Bausch Health Americas, Inc , Petaluma , CA , USA.

Background: Topical tretinoin's role in acne has been established through evidence-based guidelines. Cutaneous irritation and potential to cause or exacerbate postinflammatory hyperpigmentation (PIH) may limit use.

Objective: Evaluate safety and tolerability of novel polymeric formulation of tretinoin 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1587884DOI Listing
April 2019
3 Reads

Short lipopeptides specifically inhibit the growth of Propionibacterium acnes with antibacterial and anti-inflammatory dual action.

Br J Pharmacol 2019 Mar 30. Epub 2019 Mar 30.

Group of peptides and natural products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, P.R. China.

Background And Purpose: Propionibacterium acnes (P. acnes) is a Gram-positive bacterium associated with the skin disorder acne. In this study, considering the importance of fatty acids in the life habitat of P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bph.14680DOI Listing
March 2019
1 Read

755 nm picosecond laser for facial atrophic scar-Case reports of long-term clinical efficacy following up.

J Cosmet Dermatol 2019 Mar 28. Epub 2019 Mar 28.

P-Skin Professional Clinic, Kaohsiung, Taiwan.

Introduction: Acne vulgaris is one of the most common dermatological problems in Asia. While the disease itself is self-limited and temporary, the dystrophic texture changes after the inflammatory process are often a serious aesthetic concern. Many energy-based devices have seen good results in treating atrophic acne scars, and the picosecond laser with specific lens is one of the newer options, and lack reports on its long-term efficacy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.12925DOI Listing

Prospects of acne vaccines targeting secreted virulence factors of Cutibacterium acnes.

Expert Rev Vaccines 2019 Mar 28:1-5. Epub 2019 Mar 28.

a Department of Life Sciences , National Central University , Taoyuan , Taiwan.

Introduction: Acne vulgaris afflicts many people, and despite the multitude of the anti-acne products on the market, there is still no effective treatment that can prevent and cure this disease. The severity of acne vulgaris is highly associated with the inflammatory response to Propionibacterium acnes (P. acnes) now referred to as Cutibacterium acnes (C. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14760584.2019.1
Publisher Site
http://dx.doi.org/10.1080/14760584.2019.1593830DOI Listing
March 2019
2 Reads
4.210 Impact Factor

Significant reduction in bilirubin levels in a patient with Gilbert's Syndrome under isotretinoin treatment for acne vulgaris: A new area of use for isotretinoin?

Dermatol Ther 2019 Mar 28:e12884. Epub 2019 Mar 28.

Selcuk University Faculty of Medicine, Department of Dermatology, Konya, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12884DOI Listing

Propionibacterium acnes susceptibility to low-level 449 nm blue light photobiomodulation.

Lasers Surg Med 2019 Mar 28. Epub 2019 Mar 28.

The Johnson and Johnson Skin Research Center, Johnson and Johnson Consumer Inc. Skillman, Skillman, New Jersey.

Background And Objective: Recent advances in low-level light devices have opened new treatment options for mild to moderate acne patients. Light therapies have been used to treat a variety of skin conditions over the years but were typically only available as treatments provided by professional clinicians. Clinical application of blue light has proven to be effective for a broader spectral range and at lower fluences than previously utilized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lsm.23087DOI Listing

Effects of Intradermal Radiofrequency Treatment and Intense Pulsed Light Therapy in an Acne-induced Rabbit Ear Model.

Sci Rep 2019 Mar 25;9(1):5056. Epub 2019 Mar 25.

Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.

Acne vulgaris is a common condition that can have psychologically deleterious effects. Since current treatments carry the risks of antibiotic resistance or teratogenicity, novel treatment modalities are under investigation. Our study investigated the efficacy of intradermal radiofrequency treatment (RF) and intense pulsed light (IPL) in the treatment of acne vulgaris in a rabbit ear model. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41598-019-41322-x
Publisher Site
http://dx.doi.org/10.1038/s41598-019-41322-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434013PMC
March 2019
3 Reads

Treating Acne With Topical Antibiotics: Current Obstacles and the Introduction of Topical Minocycline as a New Treatment Option

J Drugs Dermatol 2019 Mar;18(3):240-244

Oral antibiotics are well established treatments for acne vulgaris but are associated with undesirable side effects. Topical antibiotics offer an improved safety profile but have led to an alarming rise in worldwide P. acnes resistance. Read More

View Article

Download full-text PDF

Source
March 2019
1 Read

Adapalene Gel 0.1% Versus Placebo as Prophylaxis for Anti-Epidermal Growth Factor Receptor-Induced Acne-Like Rash: A Randomized Left-Right Comparative Evaluation (APPEARANCE).

Oncologist 2019 Mar 19. Epub 2019 Mar 19.

Division of Medical Oncology and Hematology, Kobe University Graduate School of Medicine, Kobe, Japan.

Lessons Learned: The results of the APPEARANCE trial indicate that adapalene does not prevent acne-like rash over placebo when added to topical moisturizer and oral minocycline but instead may have a detrimental effect. Therefore, adapalene is not recommended as prophylaxis against acne-like rash induced by anti-epidermal growth factor receptor therapies.Given that acne-like rash was completely controlled with placebo in approximately half of patients, predictive measures to identify patients needing intensive prophylaxis are required. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1634/theoncologist.2019-0156DOI Listing
March 2019
2 Reads

Inner thigh friction as a cause of acne mechanica.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Department of Dermatology, Childrens National Medical Center, Washington, District of Columbia.

Acne mechanica is defined as being any acneiform eruption in areas of friction, pressure, stretching, rubbing, pinching, or occlusion of the skin in any individual, regardless of preexisting acne. Various causes have been reported, including prolonged back rest against a chair or bed, occlusive clothing, pressure from a prosthetic limb, and others. This is the first reported case of bilateral open comedones caused by inner thigh friction. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.13817DOI Listing

Large prospective study on adult acne in Latin America and the Iberian Peninsula: risk factors, demographics, and clinical characteristics.

Int J Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Private Practice, Mexico City, Mexico.

Background: Acne vulgaris is a chronic, multifactorial inflammatory skin disease involving the pilosebaceous unit. The prevalence of acne is high during adolescence and is known to persist into adulthood; however, the characteristics of adult acne have not been well established. In the adult population, acne has been associated with psychosocial repercussions impacting the quality of life of those who suffer it, especially in female patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ijd.14441DOI Listing

Serum levels of androgens in acne & their role in acne severity.

Pak J Med Sci 2019 Jan-Feb;35(1):146-150

Dr. Nakhshab Choudhry, PhD. Professor & Chairman, Department of Biochemistry, King Edward Medical University, Lahore, Pakistan.

Objectives: To correlate acne severity with elevated androgen levels and to compare androgen levels between cases and controls.

Methods: This case-control study was carried out in the Department of Dermatology, Mayo Hospital, Lahore from March 2016 - March 2017. Two hundred and seventy patients and eighty age and gender-matched controls were recruited after ethical approval and informed consent and categorized into mild, moderate and severe acne. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12669/pjms.35.1.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408631PMC
March 2019
1 Read

Indirect clinical markers for the detection of anabolic steroid abuse beyond the conventional doping control in athletes.

Eur J Sport Sci 2019 Mar 18:1-11. Epub 2019 Mar 18.

a Laboratory of Sports Medicine, Sports Medicine Division , Aristotle University of Thessaloniki , Thessaloniki , Greece.

Growing analytical challenges have arisen for the detection of misuse of androgenic anabolic steroids (AAS) in athletes the last years. Therefore, consideration of additional indirect markers can substantially aid the efforts to detect AAS abuse in athletes. Moreover, this approach can also help physicians to suspect AAS abuse when treating athletes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17461391.2019.1587522DOI Listing
March 2019
2 Reads

Propionibacterium acnes is a causative agent in periprosthetic infections - important implications for the treatment of acne vulgaris.

J Dtsch Dermatol Ges 2019 04 15;17(4):454-455. Epub 2019 Mar 15.

Department of Dermatology and Venereology, University Medical Center, Martin Luther University of Halle-Wittenberg, Halle (Saale), Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/ddg.13806DOI Listing

Perceptions about oral isotretinoin treatment.

Dermatol Ther 2019 Mar 13:e12873. Epub 2019 Mar 13.

Department of Dermatology, Health Science University, Ankara Oncology Training and Research Hospital, Ankara, Turkey.

There are some studies on the knowledge, beliefs, and perceptions of patients about acne vulgaris, however, there is no sufficient data on patients' beliefs about oral isotretinoin treatment (OIT). The aim of this study was to assess the knowledge, beliefs, and perceptions of the patients with acne vulgaris about the therapy of OIT and its side effects. A total of 214 patients with acne vulgaris in our outpatient clinic were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/dth.12873DOI Listing
March 2019
5 Reads

Willingness-to-pay and benefit-cost analysis of chemical peels for acne treatment in China.

Patient Prefer Adherence 2019 22;13:363-370. Epub 2019 Feb 22.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China,

Background: There have been few studies on economic evaluation of acne treatments. Chemical peel (CP), a treatment approach primarily aimed at removing acne hyperpigmentation and scarring, is gradually accepted in the Chinese market.

Objectives: This study aimed to detect willingness-to-pay (WTP) and to conduct a benefit-cost analysis for CP treatment among Chinese acne patients. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/willingness-to-pay-and-benefit-cos
Publisher Site
http://dx.doi.org/10.2147/PPA.S194615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391120PMC
February 2019
3 Reads
1.491 Impact Factor

From pathogenesis of acne vulgaris to anti-acne agents.

Arch Dermatol Res 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, West China Hospital, Sichuan University, 37 Guo Xue Xiang, Chengdu, 610041, Sichuan, People's Republic of China.

Acne vulgaris is a cutaneous chronic inflammatory disorder with complex pathogenesis. Four factors play vital roles in acne pathophysiology: hyperseborrhea and dysseborrhea, altered keratinization of the pilosebaceous duct, Cutibacterium acnes (C. acnes) and inflammation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-019-01908-xDOI Listing
March 2019
3 Reads

New indications for topical ivermectin 1% cream: a case series study.

Postepy Dermatol Alergol 2019 Feb 22;36(1):58-62. Epub 2019 Feb 22.

Evimed Medical Center, Warsaw, Poland.

Introduction: Topical ivermectin is an effective treatment for inflammatory papulopustular rosacea in adults. Positive therapeutic effects of ivermectin due to its potential anti-inflammatory properties could be achieved in the other facial dermatoses.

Aim: To assess the efficacy of topical ivermectin 1% cream therapy in mild and moderate perioral dermatitis (PD), seborrheic dermatitis (SD) and acne vulgaris (AV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5114/ada.2019.82825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409879PMC
February 2019
2 Reads

The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study.

Clin Cosmet Investig Dermatol 2019 19;12:151-161. Epub 2019 Feb 19.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand,

Background: Acne vulgaris is a common and chronic disease that impacts on physical and psychological perceptions. Cosmeceutical products are widely used as adjunct therapy to standard treatments.

Objective: To evaluate the efficacy of cosmeceutical products comprising glycolic acid, salicylic acid, gluconolactone, and licochalcone A as adjunct therapy to adapalene in mild-to-moderate acne vulgaris. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/CCID.S193730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386354PMC
February 2019
1 Read

A Review and Update of Treatment Options Using the Acne Scar Classification System.

Dermatol Surg 2019 Mar;45(3):411-422

Department of Dermatology, Northwestern Feinberg School of Medicine, Chicago, Illinois.

Background: An unfortunate consequence of acne vulgaris is residual scarring that can negatively affect a patient's quality of life.

Objective: Jacob and colleagues have previously described an acne scar classification system based on acne scar pathology that divided atrophic acne scars into icepick, rolling, and boxcar scars, and this review will evaluate new and developing treatment options for acne scarring.

Methods: A Medline search was performed on the various treatments for acne scars, and particular attention was placed on articles that used the acne scar classification system of icepick, rolling, and boxcar scars. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DSS.0000000000001765DOI Listing

What does acne genetics teach us about disease pathogenesis?

Br J Dermatol 2019 Mar 10. Epub 2019 Mar 10.

Skin Research Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore.

Background: Acne vulgaris is a highly prevalent inflammatory skin disorder with a complex pathogenesis, characterized by comedones, papules, pustules and nodules. Familial preponderance clearly indicates a genetic basis for acne vulgaris, but until recently solid genetic associations were lacking.

Results: The advent of high-resolution genotyping array technologies has allowed for large-scale studies with both family-based and cross-sectional designs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.17721DOI Listing

New and emerging drugs for the treatment of acne vulgaris in adolescents.

Expert Opin Pharmacother 2019 Mar 8:1-16. Epub 2019 Mar 8.

a Department of Dermatology , ABC Hospital , Mexico City , Mexico.

Introduction: Acne vulgaris is the most common skin disease worldwide, yet current treatment options, although effective, are associated with unwanted side effects, chronicity, relapses and recurrences. The adequate control of the four pathogenic mechanisms involved in the appearance of acne lesions is key to treatment success. This paper aims to discuss the novel treatment modalities that have surfaced in consequence of new knowledge obtained in acne pathogenesis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14656566.2019.1584182DOI Listing
March 2019
1 Read

Propionibacterium acnes-induced immunopathology correlates with health and disease association.

JCI Insight 2019 Mar 7;4(5). Epub 2019 Mar 7.

Division of Pediatric Infectious Diseases and Research Division of Immunology, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Genomic studies revealed the existence of health- and acne-associated P. acnes strains and suggested novel approaches for broadening understanding of acne vulgaris. However, clinical association of P. Read More

View Article

Download full-text PDF

Source
https://insight.jci.org/articles/view/124687
Publisher Site
http://dx.doi.org/10.1172/jci.insight.124687DOI Listing
March 2019
7 Reads

Minimise the regular laboratory monitoring during the systemic isotretinoin treatment: data of 704 patients with acne vulgaris.

J Dermatolog Treat 2019 Mar 6:1-15. Epub 2019 Mar 6.

a Department of Dermatology , Ankara Numune Training and Research Hospital , Ankara , Turkey.

Backround: Despite extensive usage of systemic isotretinoin in patients with acne for many years, laboratory monitoring protocols for adverse effects depend on the centers and there is no standardized practice for frequency and type of laboratory testing. We aimed to decrease unnecessary monitoring and to standardize our general clinical practice of our department as well as to provide patient comfort and cost saving.

Material And Method: The medical charts of 704 acne patients treated with systemic isotretinoin were reviewed retrospectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/09546634.2019.1591578DOI Listing
March 2019
4 Reads

Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography.

Lasers Surg Med 2019 Mar 5. Epub 2019 Mar 5.

Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, DK-2400, Copenhagen, Denmark.

Introduction: Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA-cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non-invasively visualize GMPs and describe photothermal tissue effects.

Objectives: To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser-mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/lsm.23076DOI Listing
March 2019
2 Reads

The Clinical Relevance and Therapeutic Benefit of Established Active Ingredients Incorporated into Advanced Foam Vehicles: Vehicle Characteristics Can Influence and Improve Patient Outcomes

J Drugs Dermatol 2019 Feb;18(2s):s100-s107

Topical delivery of therapeutic agents for skin diseases is a major advantage in dermatology. However, the efficacy and tolerability of topically applied therapies is dependent on several characteristics, including percutaneous penetration and permeation of active ingredient and lack of side effects, especially local tolerability reactions. Importantly, the ultimate performance of a topical product includes collectively the effects of the active ingredient and the impact that specific additives have on vehicle characteristics, such as penetration, permeation, epidermal barrier properties, relative irritancy, allergenicity potential, and patient acceptance/preference of the vehicle formulation used. Read More

View Article

Download full-text PDF

Source
February 2019
1 Read

Novel Tretinoin 0.05% Lotion for the Once-daily Treatment of Moderate-to-Severe Acne Vulgaris in an Adult and Adolescent Female Population

J Drugs Dermatol 2019 Feb;18(2):178-188

Background: Acne vulgaris (acne) is a common dermatological condition typically associated with adolescents, affecting about 85% of young people. However, it is also prevalent and persistent into adulthood, particularly in females. The efficacy of tretinoin in acne is well documented with large pivotal studies. Read More

View Article

Download full-text PDF

Source
February 2019
7 Reads

Efficacy of Autologous Platelet-Rich Plasma Combined With Ablative Fractional Carbon Dioxide Laser for Acne Scars: A Systematic Review and Meta-Analysis.

Aesthet Surg J 2019 Feb 27. Epub 2019 Feb 27.

Department of Dermatology, Taipei Medical University Hospital, Taipei, Taiwan.

Background: Acne scars are common and challenging clinical complications of acne vulgaris. Ablative fractional carbon dioxide (CO2) laser is a well-established treatment for acne scars; however, some postlaser adverse effects have been noted. Autologous platelet-rich plasma (PRP) can improve tissue regeneration. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/asj/advance-article/doi/10.1093/asj
Publisher Site
http://dx.doi.org/10.1093/asj/sjz048DOI Listing
February 2019
2 Reads

Shiunko and Chuoko, topical Kampo medicines, inhibit the expression of gehA encoding the extracellular lipase in Cutibacterium acnes.

J Dermatol 2019 Apr 25;46(4):308-313. Epub 2019 Feb 25.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.

Antimicrobial agents have been used for eradication of Cutibacterium (formerly Propionibacterium) acnes that is an exacerbation factor of the skin disease acne vulgaris. However, the use of antibiotics is associated with an increased risk of promoting the emergence of resistant bacteria and leading to skin dysbiosis. Traditional Japanese Kampo medicines, such as Keigairengyoto, are used to treat acne. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1346-8138.14810DOI Listing

Randomized Phase 3 Evaluation of Trifarotene 50 μG/G Cream Treatment Of Moderate Facial And Truncal ACNE.

J Am Acad Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Detroit, MI, USA.

Background: Acne vulgaris often affects the face, shoulders, chest, and back but treatment of non-facial acne has not been rigorously studied.

Objectives: Assess the safety/efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate facial and truncal acne.

Methods: Two phase III double-blind, randomized, vehicle-controlled, 12-week studies of once-daily trifarotene cream vs vehicle in subjects aged ≥9 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.02.044DOI Listing
February 2019

Platelet-rich plasma, a powerful tool in dermatology.

J Tissue Eng Regen Med 2019 Feb 22. Epub 2019 Feb 22.

Cellular and Functional Biology and Biomolecules Engineering Group, School of Science, Universidad Antonio Nariño, Bogotá, Colombia.

Platelet-rich plasma (PRP), a platelet concentrate contained in a small volume of plasma, has become a promising option in the last decade to treat different diseases related to the skin due to its high concentration of growth factors. When it is of autologous origin, it decreases the probability of suffering adverse reactions and transfusion-transmitted infections, thus it is an optimal and safe therapy for the patient. PRP has been used in the treatment of several dermatological conditions such as acne, alopecia, and skin ulcers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/term.2832DOI Listing
February 2019
6 Reads

Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts.

J Dermatol Sci 2019 Jan 26. Epub 2019 Jan 26.

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, 980-8575, Japan. Electronic address:

Background: The main pathogenesis of acne vulgaris is increase in sebum production and abnormal keratinization of the hair infundibulum. The androgens are involved in acne pathogenesis by modulating sebaceous glands to enhance sebum production. However, the molecular mechanisms of abnormal keratinization of the hair infundibulum are not fully elucidated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdermsci.2019.01.007DOI Listing
January 2019
1 Read

A Novel Combined Light-Based Treatment of Acne Vulgaris With 1,450-nm Diode Laser and 450-nm Blue Light.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.

Background: Nonablative 1,450-nm diode laser (DL) and visible blue light (BL) have been effectively used for acne with superior safety profiles.

Objective: To evaluate synergistic effects of sequential DL and BL application for acne.

Methods: A 20-week, randomized split-face study was conducted to compare clinical courses between 2 facial sides either receiving sequential application of DL and BL or BL alone in 24 patients with mild to moderate facial acne vulgaris. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/DSS.0000000000001815DOI Listing
February 2019

Dermatologic Surgical Care for Transgender Individuals.

Dermatol Surg 2019 Mar;45(3):446-457

George Washington University School of Medicine and Health Sciences, Washington, DC.

Background: Transgender individuals experience common and unique dermatologic concerns from severe acne associated with testosterone therapy in transmen to complications due to illicit silicone injections in transwomen. Currently, 2 survey studies and 4 reviews have addressed the dermatologic care of transgender individuals. However, none of them provide a focus on the dermatologic surgeon. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=00042728-201903000-0001
Publisher Site
http://dx.doi.org/10.1097/DSS.0000000000001718DOI Listing
March 2019
1 Read