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    11275 results match your criteria Acne Vulgaris

    1 OF 226

    Emerging Issues in Adult Female Acne.
    J Clin Aesthet Dermatol 2017 Jan 1;10(1):37-46. Epub 2017 Jan 1.
    Dermatology Associates/Research, Coral Gables, Florida.
    Acne vulgaris (acne) is a common affliction in adolescence and is a growing problem in adult women. Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. The long-held dogma that acne in adult women develops on the lower one-third of the face has been recently challenged, and here the authors critically review data from available literature. Read More

    Oral Administration of the Japanese Traditional Medicine Keishibukuryogan-ka-yokuinin Decreases Reactive Oxygen Metabolites in Rat Plasma: Identification of Chemical Constituents Contributing to Antioxidant Activity.
    Molecules 2017 Feb 8;22(2). Epub 2017 Feb 8.
    Center for Advanced Kampo Medicine and Clinical Research, Juntendo Graduate School of Medicine, Tokyo 113-8421, Japan.
    Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Read More

    A Report of Two Cases of Solid Facial Edema in Acne.
    Dermatol Ther (Heidelb) 2017 Feb 6. Epub 2017 Feb 6.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Introduction: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published.

    Methods: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. Read More

    Acne vulgaris: Perceptions and beliefs of Saudi adolescent males.
    J Family Community Med 2017 Jan-Apr;24(1):34-43
    Department of Dermatology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
    Introduction: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal.

    Objectives: To evaluate the perceptions and beliefs of Saudi youth on acne.

    Materials And Methods: Three hundred twenty-nine male students (aged 13-22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Read More

    Papular Acne Scars of the Nose and Chin: An Under-recognised Variant of Acne Scarring.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):241-243
    Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
    Background: Scarring following acne vulgaris is common and can be of profound psychosocial consequence.

    Aims And Objectives: We have clinically noted a variant of acne scarring, overlooked by previous categorisation schemes, which we have denominated as papular acne scars of the nose and chin. We sought to characterise these novel entities further. Read More

    Hyaluronic acid decreases lipid synthesis in sebaceous glands.
    J Invest Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. Electronic address:
    Hyaluronic acid (HA) is the major glycosaminoglycan in the extracellular matrix and has been implicated in several functions in skin cells. However, evidence is lacking regarding the HA signaling in sebaceous glands, and its potential role needs to be clarified. We investigated the role of HA in lipid production in sebaceous glands in an experimental study of human sebocytes followed by a clinical study. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Read More

    Acne and Rosacea.
    Dermatol Ther (Heidelb) 2017 Jan 1;7(Suppl 1):43-52. Epub 2017 Feb 1.
    University of Western Ontario, Windsor, ON, Canada.
    Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Read More

    Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy.
    Curr Eye Res 2017 Jan 31:1-5. Epub 2017 Jan 31.
    c Şanlıurfa Public Health Directorate , Şanlıurfa , Turkey.
    Purpose: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease.

    Method: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study. Read More

    The Role of Androgens and Estrogens in Hidradenitis Suppurativa - A Systematic Review.
    Acta Dermatovenerol Croat 2016 Dec;24(4):239-249
    Peter Theut Riis, MD, Department of Dermatology University Hospital Zealand, Køgevej 7-13, 4000 Roskilde, Denmark;
    Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. Read More

    Draft Genome Sequence of an Erythromycin-Resistant Propionibacterium acnes Isolate Recovered from Folliculitis of the Scalp.
    Genome Announc 2017 Jan 26;5(4). Epub 2017 Jan 26.
    Bacteriology and Hygiene department, Nantes University Hospital, Nantes, France
    Propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. Here, we report the draft genome sequence of an erythromycin-resistant P. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype IA1 and sequence type 18 (ST18). Read More

    A Multifactorial Comparison of Ternary Combinations of Essential Oils in Topical Preparations to Current Antibiotic Prescription Therapies for the Control of Acne Vulgaris-Associated Bacteria.
    Phytother Res 2017 Jan 26. Epub 2017 Jan 26.
    School of Pharmacy, De Montfort University, Leicester, UK.
    Acne vulgaris, a chronic condition associated with overgrowth of Propionibacterium acnes and Staphylococcus epidermidis, is commonly treated with antibiotics. However, the emergence of antibiotic resistance has resulted in a need for alternative therapies. The aim of this study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria and assess its efficacy against prescription therapies Dalacin T and Stiemycin. Read More

    Topical delivery of roxithromycin solid-state forms entrapped in vesicles.
    Eur J Pharm Biopharm 2017 Jan 21. Epub 2017 Jan 21.
    Centre of Excellence for Pharmaceutical Sciences (Pharmacen), North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. Electronic address:
    Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. Read More

    Treatment effects of lysozyme-shelled microbubbles and ultrasound in inflammatory skin disease.
    Sci Rep 2017 Jan 24;7:41325. Epub 2017 Jan 24.
    Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
    Acne vulgaris is the most common skin disorder, and is caused by Propionibacterium acnes (P. acnes) and can induce inflammation. Antibiotic therapy often needs to be administered for long durations in acne therapy, which results in extensive antibiotic exposure. Read More

    Efficacy of a twice-daily, 3-step, over-the-counter skincare regimen for the treatment of acne vulgaris.
    Clin Cosmet Investig Dermatol 2017 4;10:3-9. Epub 2017 Jan 4.
    Rodan + Fields, San Francisco, CA, USA.
    Background: Acne vulgaris (acne) is the most common skin disorder producing physical and emotional scars that can persist for years. An estimated 83% of acne sufferers self-treat, but there is lack of studies documenting the effectiveness of over-the-counter (OTC) acne treatment products.

    Objective: This study was conducted to determine the effectiveness of an OTC, 3-step, anti-acne skincare regimen in treating acne and improving the appearance of red/inflamed facial skin. Read More

    Inhibition of Propionibacterium acnes lipase activity by the antifungal agent ketoconazole.
    Microbiol Immunol 2017 Jan;61(1):42-44
    Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
    The common skin disease acne vulgaris is caused by Propionibacterium acnes. A lipase secreted by this microorganism metabolizes sebum and the resulting metabolites evoke inflammation in human skin. The antifungal drug ketoconazole inhibits P. Read More

    Morbihan disease complicated by dermatosis neglecta: An unique presentation.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Dermatopathology Division, Department of Pathology, Sylvester Comprehensive Cancer Center, Miami, Florida.
    Morbihan disease, also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases. Few cases have been described in the literature, as its first description by Robert Degos in 1957. Read More

    Results of a Phase 2, Randomized,Vehicle-Controlled Study Evaluating the Efficacy,Tolerability, and Safety of Daily or Twice Daily SB204 for the Treatment of Acne Vulgaris.
    J Drugs Dermatol 2016 Dec;15(12):1496-15027
    Objective: This randomized, double-blind, placebo-controlled, Phase 2 study compared efficacy, tolerability, and safety of SB204 once or twice daily to vehicle in the treatment of acne vulgaris.

    Methods: Eligible subjects were to be between 12 and 40 years old, have facial acne vulgaris with 25 to 70 non-inflammatory lesions, 20 to 40 inflammatory lesions, no more than 2 nodules, and a baseline Investigator's Global Assessment (IGA) score of moderate or severe. The co-primary efficacy endpoints were the absolute change in inflammatory and non-inflammatory lesion counts and IGA success rate (baseline to week 12). Read More

    Skin microbiome and acne vulgaris: staphylococcus, a new actor in acne.
    Exp Dermatol 2017 Jan 17. Epub 2017 Jan 17.
    La Roche-Posay Dermatological Laboratories, Asnières, France.
    Propionibacterium acnes (P. acnes), the sebaceous gland and follicular keratinocytes are considered the three actors involved in the development of acne. This exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. Read More

    Multiple Activities of Punica granatum Linne against Acne Vulgaris.
    Int J Mol Sci 2017 Jan 12;18(1). Epub 2017 Jan 12.
    PhD Program for Clinical Drug Discovery of Chinese Herbal Medicine, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
    Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. Read More

    Analysis of the Surface, Secreted, and Intracellular Proteome of Propionibacterium acnes.
    EuPA Open Proteom 2015 Dec 16;9:1-7. Epub 2015 Jun 16.
    Division of Dermatology and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA; Department of Dermatology, Greater Los Angeles Healthcare System Veterans Affairs, Los Angeles, CA.
    Propionibacterium acnes , plays an important role in acne vulgaris and other diseases. However, understanding of the exact mechanisms of P. acnes pathogenesis is limited. Read More

    Clinical characteristics and epidermal barrier function of papulopustular rosacea: A comparison study with acne vulgaris.
    Pak J Med Sci 2016 Nov-Dec;32(6):1344-1348
    Ji Li, Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To evaluate the clinical characteristics and epidermal barrier function of papulopustular rosacea by comparing with acne vulgaris.

    Methods: Four hundred and sixty-three papulopustular rosacea patients and four hundred and twelve acne vulgaris patients were selected for the study in Xiangya Hospital of Central South University from March 2015 to May 2016. They were analyzed for major facial lesions, self-conscious symptoms and epidermal barrier function. Read More

    Chemical pharmacotherapy options for managing adult acne.
    Expert Opin Pharmacother 2017 Feb 23;18(3):263-273. Epub 2017 Jan 23.
    a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
    Introduction: The incidence of adult acne is increasing worldwide. Despite clinical overlap with conventional acne, it has distinct features. Areas covered: A literature search of English-language review articles, randomized control studies and retrospective studies conducted over the past 30 years was performed using PubMed and Google Scholar. Read More

    The effect of systemic isotretinoin treatment on skin biophysicalparameters among patients with acne vulgaris.
    Turk J Med Sci 2016 Dec 20;46(6):1641-1644. Epub 2016 Dec 20.
    Department of Dermatology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Background/aim: Systemic isotretinoin has been widely considered an effective and safe medical treatment for severe and refractory acne for nearly 3 decades. However, it also appears to cause undesirable cutaneous side effects. The aim of this study was to prospectively measure biophysical parameters of skin function among patients with acne vulgaris before and after 3 months of isotretinoin therapy, including pH, temperature, sebum content, skin hydration, and transepidermal water loss. Read More

    Evaluation of Structural Isomers, Molecular Interactions, Reactivity Descriptors, and Vibrational Analysis of Tretinoin.
    Anal Sci 2017 ;33(1):83-87
    Department of Physics, University of Lucknow.
    Tretinoin is known to be a pharmaceutical drug for treating acne vulgaris, keratosis pilaris, and acute promyelocytic leukemia. In order to reveal the possible conformers of tretinoin, the energies of all the conformers through rotational bonds have been evaluated by systematic rotor search analysis. The intramolecular interactions ranging from strong hydrogen bonds to weak van der Waals forces present in tretinoin have been distinguished with the help of electron density mapping and wavefunction analysis. Read More

    Adult Acne: Prevalence and Portrayal in Primary Healthcare Patients, in the Greater Porto Area, Portugal.
    Acta Med Port 2016 Sep 30;29(9):507-513. Epub 2016 Sep 30.
    Centro de Investigação Interdisciplinar em Saúde. Universidade Católica do Porto. Porto. Portugal.
    Introduction: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. Read More

    Use of nicotinamide in dermatology.
    Clin Exp Dermatol 2017 Mar 4;42(2):137-144. Epub 2017 Jan 4.
    Dermatological Surgery and Laser Unit, St John's Institute of Dermatology, St Thomas' Hospital, London, UK.
    Nicotinamide (niacinamide) is the water-soluble, amide form of vitamin B3. We review the evidence underlying the use of nicotinamide for various dermatological indications, including nonmelanoma cancer prophylaxis, blistering disorders, acne vulgaris and cosmetic indications, and speculate upon its future role in dermatological practice. Read More

    Green Tea and Other Tea Polyphenols: Effects on Sebum Production and Acne Vulgaris.
    Antioxidants (Basel) 2016 Dec 29;6(1). Epub 2016 Dec 29.
    Department of Dermatology, University of California-Davis, Sacramento, CA 95816, USA.
    Polyphenols are antioxidant molecules found in many foods including nuts, fruits, vegetables, chocolate, wine, and tea. Polyphenols have antimicrobial, anti-inflammatory, and antineoplastic properties. Recent studies suggest that tea polyphenols may be used for reducing sebum production in the skin and for treatment of acne vulgaris. Read More

    Olumacostat glasaretil, a novel topical sebum inhibitor, in the treatment of acne vulgaris: A phase IIa, multicenter, randomized, vehicle-controlled study.
    J Am Acad Dermatol 2016 Oct 28. Epub 2016 Oct 28.
    Windsor Clinical Research Inc, Windsor, Ontario, Canada.
    Background: Olumacostat glasaretil (OG) inhibits acetyl-coenzyme A carboxylase, the enzyme responsible for the first, rate-limiting step in de novo fatty acid synthesis. OG inhibited in vitro human sebocyte lipid production and reduced in vivo sebaceous gland size in hamster ears.

    Objectives: Safety and efficacy of OG 7. Read More

    Decreased eicosapentaenoic acid levels in acne vulgaris reveals the presence of a proinflammatory state.
    Prostaglandins Other Lipid Mediat 2016 Dec 23;128-129:1-7. Epub 2016 Dec 23.
    Department of Medical Biochemistry, Akdeniz University Medical Faculty, Antalya, Turkey. Electronic address:
    This study aimed to determine circulating levels of polyunsaturated fatty acids (PUFAs), secretory phospholipase A2 (sPLA2), lipoprotein lipase (LPL) and measure circulating protein levels of angiopoietin-like protein 3 (ANGPTL3), ANGPTL4, cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in patients with acne vulgaris. Serum from 21 control subjects and 31 acne vulgaris patients were evaluated for levels of arachidonic acid (AA, C20:4n- 6), dihomo-gamma-linolenic acid (DGLA, C20:3n-6), eicosapentaenoic acid (EPA, C20:5n-3) and docosahexaenoic acid (DHA, C22:6n-3). PUFA levels were determined by an optimized multiple reaction monitoring (MRM) method using ultra fast-liquid chromatography (UFLC) coupled with tandem mass spectrometry (MS/MS). Read More

    Recognition of Propionibacterium acnes by human TLR2 heterodimers.
    Int J Med Microbiol 2016 Dec 12. Epub 2016 Dec 12.
    Freie Universität Berlin, Institute of Pharmacy (Pharmacology and Toxicology), Berlin, Germany. Electronic address:
    Propionibacterium acnes has been considered as a crucial contributor to the pathogenesis of acne vulgaris. The interaction between P. acnes and the host is mainly mediated by Toll like receptor (TLR) 2 recognition. Read More

    Dapsone 7.5% Gel: A Review in Acne Vulgaris.
    Am J Clin Dermatol 2017 Feb;18(1):139-145
    Springer, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
    Dapsone 7.5% gel (Aczone(®)) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. Read More

    Content Validity of Patient-Reported Outcome Instruments Used With Pediatric Patients With Facial Differences: A Systematic Review.
    Cleft Palate Craniofac J 2016 Dec 21. Epub 2016 Dec 21.
    Objective:   The aim of this systematic review was to identify patient-reported outcome (PRO) instruments used in research with children/youth with conditions associated with facial differences to identify the health concepts measured.

    Design:   MEDLINE, EMBASE, CINAHL, and PsycINFO were searched from 2004 to 2016 to identify PRO instruments used in acne vulgaris, birthmarks, burns, ear anomalies, facial asymmetries, and facial paralysis patients. We performed a content analysis whereby the items were coded to identify concepts and categorized as positive or negative content or phrasing. Read More

    Biological and Pharmacological Evaluation of Dimethoxycurcumin: A Metabolically Stable Curcumin Analogue with a Promising Therapeutic Potential.
    J Cell Physiol 2016 Dec 20. Epub 2016 Dec 20.
    Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
    Dimethoxycurcumin (DiMC) is a synthetic analogue of curcumin with superior inter-related pro-oxidant and anti-cancer activity, and metabolic stability. Numerous studies have shown that DiMC reserves the biologically beneficial features, including anti-inflammatory, anti-carcinogenic and cytoprotective properties, almost to the same extent as curcumin exhibits. DiMC lacks the phenolic-OH groups as opposed to curcumin, dimethoxycurcumin, and bis-demethoxycurcumin that all vary in the number of methoxy groups per molecule, and has drawn the attentions of researchers who attempted to discover the structure-activity relationship (SAR) of curcumin. Read More

    Verantwortlicher Umgang mit Antibiotika: Notwendigkeit der Antibiotikareduktion in der Aknetherapie.
    J Dtsch Dermatol Ges 2016 Dec;14(12):1319-1327
    Der übermäßige oder unkritische weltweite Einsatz von Antibiotika in der Medizin hat die Ausbreitung von Antibiotikaresistenzen beschleunigt. In einigen Bereichen sind viele Antibiotika bei bakteriellen Infektionen, die zuvor noch gut auf antibakterielle Wirkstoffe reagierten, mittlerweile wirkungslos geworden. Dermatologen/Venerologen setzten orale und topische Antibiotika bei der Behandlung von Acne vulgaris routinemäßig ein, obwohl Akne weder eine infektiöse Erkrankung ist noch alleine durch das Propionibacterium getriggert wird. Read More

    Azelainsäure 20 % Creme: Auswirkung auf Lebensqualität und Krankheitsaktivität bei erwachsenen Patientinnen mit Acne vulgaris.
    J Dtsch Dermatol Ges 2016 Dec;14(12):1249-1260
    Hautarztpraxis, 9020, Klagenfurt, Österreich.
    Hintergrund: Zur Wirksamkeit von Aknetherapien und deren Auswirkungen auf die Lebensqualität erwachsener Patienten liegen kaum Daten vor. ZIEL: Erhebung der Wirkung von Azelainsäure 20 % Creme (Skinoren(®) ) auf Akne-Schweregrad und krankheitsbedingte Lebensqualität.

    Patienten Und Methodik: Nichtinterventionelle Studie bei erwachsenen Patientinnen mit leichter bis mittelschwerer Akne. Read More

    Acne: Kids are not just little people.
    Clin Dermatol 2016 Nov - Dec;34(6):710-716. Epub 2016 Jul 9.
    Department of Dermatology, University of Connecticut School of Medicine, Farmington, CT; Department of Pediatrics, University of Connecticut Health Science Center, Farmington, CT.
    Acne vulgaris is a common inflammatory disease of the pilosebaceous follicles that affects patients of all ages, from neonates to adults. We have compared and contrasted the clinical presentation of acne in neonates, infants, children, teenagers, and young adults and review the scenarios in which further systemic endocrine or hormonal tests are indicated. We also discuss age-dependent treatment considerations, including appropriate oral antimicrobial regimens and the proper dosing of isotretinoin in young children versus teenagers and adults. Read More

    Rhodomyrtone inhibits lipase production, biofilm formation, and disorganizes established biofilm in Propionibacterium acnes.
    Anaerobe 2017 Feb 5;43:61-68. Epub 2016 Dec 5.
    Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand; Excellence Research Laboratory on Natural Products, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla, 90112, Thailand. Electronic address:
    Virulence enzymes and biofilm a play crucial role in the pathogenesis of Propionibacterium acnes, a major causative agent of acne vulgaris. In the present study, the effects of rhodomyrtone, a pure compound identified from Rhodomyrtus tomentosa (Aiton) Hassk. leaves extract against enzyme production and biofilm formation production by 5 clinical isolates and a reference strain were evaluated. Read More

    Comparison of pulsed dye laser versus combined pulsed dye laser and Nd:YAG laser in the treatment of inflammatory acne vulgaris.
    J Cosmet Laser Ther 2017 Feb 2:1-11. Epub 2017 Feb 2.
    b Helwan University Hospital , Cairo , Egypt.
    Background: Both pulsed dye laser and combined 585/1064-nm (sequential dual-wavelength PDL and Nd:YAG) laser improves inflammatory skin disorders including acne vulgaris.

    Objective: To compare the efficacy of 585-nm pulsed dye laser versus sequential dual-wavelength PDL and Nd:YAG in treatment of acne vulgaris.

    Patients And Method: Thirty patients with acne vulgaris were treated by PDL alone on half of the face while contra lateral half was treated by combined 585/1064 nm laser. Read More

    Comparison the effectiveness of pyruvic acid 50% and salicylic acid 30% in the treatment of acne.
    J Res Med Sci 2016 9;21:31. Epub 2016 May 9.
    Department of Biostatistics and Epidemiology, Skin Diseases and Leishmaniasis Research Center, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.
    Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles and one of the most common skin diseases. The peeling method has been recently found to be effective for acne treatment. This study aimed to compare the efficacy of pyruvic acid 50% and salicylic acid 30% peeling in the treatment of mild to moderate acne. Read More

    Azelaic acid 20 % cream: effects on quality of life and disease severity in adult female acne patients.
    J Dtsch Dermatol Ges 2016 Dec 29;14(12):1249-1259. Epub 2016 Nov 29.
    Dermatology Practice, 9020, Klagenfurt, Austria.
    Background: Data on the efficacy of acne treatments and their impact on quality of life (QoL) in adult patients is sketchy.

    Objective: Assessment of the efficacy of azelaic acid 20 % cream (Skinoren(®) ) on acne severity and disease-related QoL.

    Patients And Methods: Noninterventional study in adult female patients with mild to moderate acne. Read More

    Not every patient needs triglyceride check, but all can get pancreatitis: A systematic review and clinical characterization of Isotretinoin associated Pancreatitis.
    Br J Dermatol 2016 Nov 28. Epub 2016 Nov 28.
    Division of Dermatology, Department of Medicine, J.H. Stroger Hospital of Cook County, Chicago, Illinois, USA.
    Isotretinoin is a medication to treat primarily nodulocystic acne vulgaris. A serious complication is pancreatitis, either idiosyncratic, and not preventable or predictable; or due to elevated triglycerides. Triglyceride are elevated in practically all patients on isotretinoin, but may not be abnormal, or too minimally elevated to pose a pancreatitis risk. Read More

    Anti-Acne Activity of Italian Medicinal Plants Used for Skin Infection.
    Front Pharmacol 2016 10;7:425. Epub 2016 Nov 10.
    Department of Dermatology, Emory University School of MedicineAtlanta, GA, USA; Center for the Study of Human Health, Emory University College of Arts and SciencesAtlanta, GA, USA; Antibiotic Resistance Center, Emory UniversityAtlanta, GA, USA.
    Propionibacterium acnes is implicated in the pathogenesis of acne vulgaris, which impacts >85% of teenagers. Novel therapies are in high demand and an ethnopharmacological approach to discovering new plant sources of anti-acne therapeutics could contribute to filling this void in effective therapies. The aims of our study were two-fold: (1) To determine if species identified in ethnopharmacological field studies as having traditional uses for skin and soft tissue infection (SSTI) exhibit significantly more activity against P. Read More

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