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    Randomized, controlled trial split-faced study of 595-nm pulsed dye laser in the treatment of acne vulgaris and acne erythema in adolescents and early adulthood.
    Int J Dermatol 2017 Apr 26. Epub 2017 Apr 26.
    Department of Pediatrics, Chulalongkorn University, Bangkok, Thailand.
    The high prevalence of acne vulgaris in teenagers has increased comorbidities. Lasers offer alternative options for acne treatment because they have rapid action, low systemic adverse effects, and do not require everyday treatment. To study the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood, we designed a blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm(3) pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study in patients with mild to moderate acne by comparing the laser-treated and non-treated side. Read More

    Prioritising treatment outcomes: how people with acne vulgaris decide if their treatment is working.
    J Evid Based Med 2017 Apr 26. Epub 2017 Apr 26.
    National Institute for Health and Clinical Effectiveness, City Tower, Piccadilly Plaza, Manchester, UK.
    Aim: To collect information about how people with acne make day-to-day decisions concerning the effectiveness of their treatment.

    Methods: Between May and August 2013, an optional question was embedded in the James Lind Alliance Acne Priority Setting Partnership's online survey to collect treatment uncertainties. The question asked people with acne to 'Tell us in your own words how you decide if your treatment has been effective'. Read More

    Over-the-counter and Prescription Medications for Acne: A Cross-Sectional Survey in a Sample of University Students in Saudi Arabia.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):120-123
    Department of Dermatology, College of Medicine, King Faisal University, Saudi Arabia.
    Introduction And Background: Acne is a very common dermatological condition found among the adolescent population in Saudi Arabia. Many patients with acne try various forms of self-medication, over the counter medicines (OTC), and prescription medicines for the same.

    Materials And Methods: This was a cross-sectional study among university students in the Kingdom of Saudi Arabia (KSA). Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    Improvement of Atrophic Acne Scars in Skin of Color Using Topical Synthetic Epidermal Growth Factor (EGF) Serum: A Pilot Study.
    J Drugs Dermatol 2017 Apr;16(4):322-326

    BACKGROUND: Atrophic scarring in skin of color is a common, permanent, and distressing result of uncontrolled acne vulgaris. Ablative lasers and chemical peels are frequently used to improve the appearance of atrophic scars, primarily through the stimulation of collagen and elastin; however, these treatment modalities are associated with risks, such as dyspigmentation and hypertrophic scarring, especially in patients with darker skin.

    OBJECTIVE: We evaluated the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color. Read More


    Clindamycin phosphate-tretinoin combination gel revisited: status report on a specific formulation used for acne treatment.
    Cutis 2017 Mar;99(3):179-183
    JDR Dermatology Research LLC/Thomas Dermatology, Las Vegas and Henderson, Nevada, and Touro University Nevada, Henderson, USA.
    Topical agents, including retinoids and antibiotics, are commonly used to treat acne vulgaris (AV) and remain as components of acne treatment guidelines. Approved topical combination formulations offer the advantages of established efficacy, decreased frequency of application, and improved convenience for patients. This article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Read More

    Bactericidal activity and post-antibiotic effect of ozenoxacin against Propionibacterium acnes.
    J Infect Chemother 2017 Apr 4. Epub 2017 Apr 4.
    Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Japan.
    Ozenoxacin, a novel non-fluorinated topical quinolone, is used for the treatment of acne vulgaris in Japan. We investigated bactericidal activity and post-antibiotic effect (PAE) of ozenoxacin against Propionibacterium acnes, a major causative bacterium of acne vulgaris. The minimum inhibitory concentrations (MICs) of ozenoxacin against 3 levofloxacin-susceptible strains (MIC of levofloxacin; ≤4 μg/mL) and 3 levofloxacin-resistant strains (MIC of levofloxacin; ≥8 μg/mL) ranged from 0. Read More

    A randomized, double-blind, placebo-controlled trial to determine the efficacy and safety of lactoferrin with vitamin E and zinc as an oral therapy for mild to moderate acne vulgaris.
    Int J Dermatol 2017 Mar 30. Epub 2017 Mar 30.
    Research and Development Division, United Laboratories, Inc., Mandaluyong City, Philippines.
    Lactoferrin is an iron-binding milk-derived protein that has shown antibacterial and anti-inflammatory effects in vitro and in vivo. The objective of this study was to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris. In this randomized, double-blind, placebo-controlled trial, 168 subjects aged 13-40 years old were randomly assigned to take either a capsule formulation containing lactoferrin with vitamin E and zinc or placebo twice a day for 3 months. Read More

    Light therapies for acne: abridged Cochrane systematic review including GRADE assessments.
    Br J Dermatol 2017 Mar 24. Epub 2017 Mar 24.
    Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
    We undertook a Cochrane review of randomized controlled trials (RCTs) evaluating the effects of light-based interventions for acne vulgaris. We searched the Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, LILACS, ISI Web of Science, and grey literature sources (September 2015). We used the Grading of Recommendations Assessment, Development and Evaluation Working Group approach to assess the quality of evidence (QE). Read More

    ALA-PDT suppressing the cell growth and reducing the lipogenesis in human SZ95 sebocytes by mTOR signaling pathway in vitro.
    Photodiagnosis Photodyn Ther 2017 Mar 19. Epub 2017 Mar 19.
    Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, PR China. Electronic address:
    Background: 5-Aminolevulinic acid mediated -photodynamic therapy (ALA-PDT) is known to be effective in treating acne vulgaris and other sebaceous gland-related diseases. However, thetherapeutic mechanisms of ALA-PDT still remain undetermined. In this study, we aimed to investigate theeffects and mechanisms of ALA-PDTon the cell growth and lipogenesis of human SZ95 sebocytes. Read More

    Multiple miliary osteoma cutis of the face associated with Albright hereditary osteodystrophy in the setting of acne vulgaris: a case report.
    Dermatol Online J 2017 Mar 15;23(3). Epub 2017 Mar 15.
    Department of Internal Medicine, University of Central Florida College of Medicine, Orlando Florida.
    Osteoma cutis is a condition characterized by theformation of bone within the skin. Such aberrantossification of the skin and subcutaneous tissue isconsidered primary when it arises in the absence ofunderlying tissue damage or a preceding cutaneouslesion. Conversely, secondary osteoma cutis occurswhen skin ossification is the result of a pre-existingskin lesion, trauma, or inflammatory process [1,2]. Read More

    Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effects.
    J Dermatolog Treat 2017 Apr 2:1-13. Epub 2017 Apr 2.
    b Department of Dermatology , American University of Beirut , Beirut , Lebanon.
    Retinoids are a class of compounds derived from vitamin A or having structural and/or functional similarities with vitamin A. They are classified into three generations based on their molecular structures. Inside the body, retinoids bind to several classes of proteins including retinoid-binding proteins and retinoid nuclear receptors. Read More

    Prevalence and Risk Factors of Acne Scarring Among Patients Consulting Dermatologists in the Unites States.
    J Drugs Dermatol 2017 Feb;16(2):97-102
    Although there have been few formal studies, scarring is a known bothersome companion of acne vulgaris. We performed a prospective study of subjects consulting a dermatologist for active acne to assess the frequency of acne scarring. Investigators performed a short questionnaire on all acne patients seen at their office for one consecutive 5-day work week to assess scar frequency. Read More

    Adverse effects of isotretinoin: A large, retrospective review.
    Dermatol Ther 2017 Mar 14. Epub 2017 Mar 14.
    Department of Geriatrics, Healthy Ageing Research Centre (HARC), Medical University of Lodz, Pl. Hallera 1, Lodz, 90-647, Poland.
    Acne is a very common and disfiguring disease that affects mostly adolescents and, to some extent, adults. The objective of our study was to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris in a 5-year observation. Retrospective, comparative study was carried out in Poland and Romania from January 2012 to August 2016. Read More

    Twelve-week, multicenter, placebo-controlled, randomized, double-blind, parallel-group, comparative phase II/III study of benzoyl peroxide gel in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Mar 11. Epub 2017 Mar 11.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    A placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study was conducted to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris. Efficacy was evaluated by counting all inflammatory and non-inflammatory lesions. Safety was evaluated based on adverse events, local skin tolerability scores and laboratory test values. Read More

    The Role of Photodynamic Therapy in Acne: An Evidence-Based Review.
    Am J Clin Dermatol 2017 Mar 8. Epub 2017 Mar 8.
    Department of Dermatology, University of Illinois at Chicago, 808 S. Wood St., Suite 380, Chicago, IL, 60612, USA.
    Background: Acne vulgaris is a highly prevalent skin disorder that affects almost all adolescents and can persist into adulthood. Photodynamic therapy (PDT) is an emerging treatment for acne that involves the use of a photosensitizer in combination with a light source and oxygen.

    Methods: We performed a systematic review of the literature and critically evaluated the studies. Read More

    Therapeutic approaches to reducing atrophic acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):190-194. Epub 2016 Oct 27.
    National and Kapodistrian University of Athens, Athens, Greece.
    Atrophic acne scars are a common and undesirable outcome of acne vulgaris related to both its severity and delay in treatment. Such scars can be classified according to the depth and shape of the collagen loss: ice pick, boxcar, or rolling. The presence of atrophic acne scars can compromise the self-esteem and psychologic well-being of patients, creating a challenge for both the patient and the dermatologist. Read More

    Laser and light-based treatments of acne and acne scarring.
    Clin Dermatol 2017 Mar - Apr;35(2):183-189. Epub 2016 Oct 27.
    Dermatology and Laser Surgery Center, Yale University School of Medicine, New York, New York , 955 Park Avenue, New York, NY 10028. Electronic address:
    The treatment of acne and acne scarring with lasers and light-based and energy-based technologies has become an integral component of our therapeutic arsenal. Lasers including infrared wavelengths and pulsed dye lasers; light devices including blue light, red light, and broadband light; and photodynamic therapy with aminolevulinic acid and methylaminolevulinic acid have been shown to be effective in the treatment of acne vulgaris. The optimal outcomes are achieved with photodynamic therapy combined with medical therapy. Read More

    Objective assessment of acne.
    Clin Dermatol 2017 Mar - Apr;35(2):147-155. Epub 2016 Oct 27.
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
    A precise and reliable assessment of acne severity is unarguably the most essential clinical method when it comes to monitoring and choosing optimal treatment in the daily practice. Since the early 1960s, different severity assessment systems have been described in the literature. The two commonly used concepts are global gradings and lesion counting. Read More

    Understanding the role of Propionibacterium acnes in acne vulgaris: The critical importance of skin sampling methodologies.
    Clin Dermatol 2017 Mar - Apr;35(2):118-129. Epub 2016 Oct 27.
    Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden. Electronic address:
    Acne vulgaris is a chronic inflammatory skin condition classified by the Global Burden of Disease Study as the eighth most prevalent disease worldwide. The pathophysiology of the condition has been extensively studied, with an increase in sebum production, abnormal keratinization of the pilosebaceous follicle, and an inflammatory immune response all implicated in its etiology. One of the most disputed points, however, is the role of the gram-positive anaerobic bacterium Propionibacterium acnes in the development of acne, particularly when this organism is also found in normal sebaceous follicles of healthy skin. Read More

    Alexithymia in different dermatologic patients.
    Asian J Psychiatr 2017 Feb 12;25:42-45. Epub 2016 Oct 12.
    Department of Industrial Management, University of Tehran, Tehran, Iran.
    Alexithymia is a personality trait characterized by difficulties in differentiating and describing feelings. Research indicates that alexithymia can be considered as a possible risk factor for a variety of medical conditions. The purpose of our study was to compare and assess the prevalence of alexithymia in patients with psoriasis, alopecia areata, vitiligo and acne vulgaris. Read More

    The use of isotretinoin in low doses and unconventional treatment regimens in different types of acne: a literature review.
    Postepy Dermatol Alergol 2017 Feb 7;34(1):1-5. Epub 2017 Feb 7.
    Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland.
    High effectiveness of isotretinoin treatment for severe types of acne resistant to antibiotics has been widely recognized. However, the recommended doses in conventional therapy, according to consensus of the Polish Dermatological Society, may cause serious adverse effects. Thus, research into less stressful, alternative treatment regimens with the use of low doses of isotretinoin has been carried out. Read More

    Prevalence of acne vulgaris and its impact of the quality of life among secondary school-aged adolescents in Sohag Province, Upper Egypt.
    J Cosmet Dermatol 2017 Mar 2. Epub 2017 Mar 2.
    Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Upper Egypt, Sohag, Egypt.
    Background: Acne vulgaris is the most common dermatological condition encountered in adolescents.

    Aim: It was to determine the prevalence of acne vulgaris and its impact of the quality of life among adolescents attending secondary schools in Sohag Province, Upper Egypt.

    Patients And Methods: This was a cross-sectional study conducted in randomly selected governmental and technical secondary schools in Sohag Province, Upper Egypt. Read More

    Oral Antibacterial Therapy for Acne Vulgaris: An Evidence-Based Review.
    Am J Clin Dermatol 2017 Mar 2. Epub 2017 Mar 2.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, 240 East 38th Street, 11th Floor, New York, NY, 10016, USA.
    Background: To some degree, acne vulgaris affects nearly every individual worldwide. Oral antibiotic therapy is routinely prescribed for the treatment of moderate to severe inflammatory acne; however, long-term use of oral antibiotics for acne may have unintended consequences.

    Objective: The aim of this study was to provide a systematic evaluation of the scientific evidence on the efficacy and appropriate use of oral antibiotics in the treatment of acne. Read More

    Global Skin Disease Morbidity and Mortality: An Update From the Global Burden of Disease Study 2013.
    JAMA Dermatol 2017 Mar 1. Epub 2017 Mar 1.
    Institute for Health Metrics and Evaluation, University of Washington, Seattle.
    Importance: Disability secondary to skin conditions is substantial worldwide. The Global Burden of Disease Study 2013 includes estimates of global morbidity and mortality due to skin diseases.

    Objective: To measure the burden of skin diseases worldwide. Read More

    Review and Management of Acneiform Eruptions in Patients with Immune Disorders.
    Am J Clin Dermatol 2017 Feb 28. Epub 2017 Feb 28.
    Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA.
    Immune disorders are associated with acne or acneiform lesions secondary to the occurrence of acne vulgaris or acneiform eruptions arising as a result of immunosuppressive medication or infection. In this review, we aim to provide an overview of acne and acneiform eruptions that can arise in the immunosuppressed host. Tips for differentiating between various acneiform entities are discussed, as well as a brief overview of treatment considerations. Read More

    Silk textile with antimicrobial AEM5772/5 (Dermasilk): a pilot study with positive influence on acne vulgaris on the back.
    Int J Dermatol 2017 May 27;56(5):589-591. Epub 2017 Feb 27.
    Center of Aesthetic Medicine, Department of Dermatology, Medical University Graz, Graz, Austria.
    Background: The use of special silk textiles (Dermasilk) has shown positive effects on chronic inflammatory diseases like lichen sclerosus et atrophicus, atopic dermatitis, diabetic ulcerations, and vulvovaginal candidiasis.

    Objective: Wearing T-shirts of this particular fabric could be useful in the management of patients with acne vulgaris on the back and trunk.

    Material And Methods: Dermasilk T-shirts were given to 14 patients with acne vulgaris papulopustulosa on the back. Read More

    Excessive serous retinal detachment during the use of isotretinoin.
    Int Ophthalmol 2017 Feb 25. Epub 2017 Feb 25.
    Ankara Ulucanlar Eye Education and Research Hospital, Ulucanlar Cd. No: 59, 06230, Altindag, Ankara, Turkey.
    Purpose: To report a case unilateral excessive subretinal fluid during the use of isotretinoin.

    Method: A case report. A patient who used isotretinoin orally for nodular-cystic acne vulgaris developed concurrent unilaterally excessive subretinal fluid and serous retinal detachment. Read More

    Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes.
    Front Microbiol 2017 8;8:164. Epub 2017 Feb 8.
    Bacteriophage Laboratory, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Phage Therapy Unit, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of SciencesWroclaw, Poland; Department of Clinical Immunology, Transplantation Institute, Medical University of WarsawWarsaw, Poland.
    Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Read More

    Insulin-Like Growth Factor-1 Increases the Expression of Inflammatory Biomarkers and Sebum Production in Cultured Sebocytes.
    Ann Dermatol 2017 Feb 3;29(1):20-25. Epub 2017 Feb 3.
    Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea.
    Background: Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. Read More

    The role of nicotinamide in acne treatment.
    Dermatol Ther 2017 Feb 21. Epub 2017 Feb 21.
    Department of Dermatology & Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.
    Safe and effective treatment options for acne vulgaris are needed to address side effects and increasing rates of antibiotic resistance from current treatments. Nicotinamide is a vitamin with potent anti-inflammatory properties that could offer a potential treatment option. We aim to summarize the relevant literature on the role of nicotinamide in acne vulgaris and discuss the next steps necessary to move this approach into clinical practice. Read More

    Views of oral antibiotics and advice seeking about acne: a qualitative study of online discussion forums.
    Br J Dermatol 2017 Feb 20. Epub 2017 Feb 20.
    University of Southampton.
    Background: Acne vulgaris is common and can significantly impair quality of life, yet little is known about patients' understanding of acne and its treatments. Oral antibiotics are widely used for acne, despite concerns about antibiotic resistance. People are increasingly turning to online discussion forums for advice and information on these sites may influence health beliefs and treatment adherence. Read More

    Propionibacterium acnes is developing gradual increase in resistance to oral tetracyclines.
    J Med Microbiol 2017 Jan;66(1):8-12
    1​Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
    Propionibacterium acnes is an anaerobic bacterium that causes deep infection in organs and prosthetic joints, in addition to acne vulgaris. Many tetracycline-resistant P. acnes strains have been isolated because oral tetracyclines are frequently used as an acne treatment against P. Read More

    Emerging Issues in Adult Female Acne.
    J Clin Aesthet Dermatol 2017 Jan 1;10(1):37-46. Epub 2017 Jan 1.
    Dermatology Associates/Research, Coral Gables, Florida.
    Acne vulgaris (acne) is a common affliction in adolescence and is a growing problem in adult women. Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. The long-held dogma that acne in adult women develops on the lower one-third of the face has been recently challenged, and here the authors critically review data from available literature. Read More

    Oral Administration of the Japanese Traditional Medicine Keishibukuryogan-ka-yokuinin Decreases Reactive Oxygen Metabolites in Rat Plasma: Identification of Chemical Constituents Contributing to Antioxidant Activity.
    Molecules 2017 Feb 8;22(2). Epub 2017 Feb 8.
    Center for Advanced Kampo Medicine and Clinical Research, Juntendo Graduate School of Medicine, Tokyo 113-8421, Japan.
    Insufficient detoxification and/or overproduction of reactive oxygen species (ROS) induce cellular and tissue damage, and generated reactive oxygen metabolites become exacerbating factors of dermatitis. Keishibukuryogan-ka-yokuinin (KBGY) is a traditional Japanese medicine prescribed to treat dermatitis such as acne vulgaris. Our aim was to verify the antioxidant properties of KBGY, and identify its active constituents by blood pharmacokinetic techniques. Read More

    Association between Acne and Serum Pro-inflammatory Cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in Mustard Gas-Exposed Patients: Sardasht-Iran Cohort Study.
    Arch Iran Med 2017 Feb;20(2):86-91
    Department of Biostatistics and Social Medicine, Zanjan University of Medical Sciences, Zanjan, I.R. Iran.
    Background: Acne vulgaris is a very common chronic inflammatory disorder, yet its pathogenesis is not clearly understood. As part of the SICS, this study was conducted to evaluate the association between the incidence of acne vulgaris in SM-exposed subjects (20 years after the exposure) and serum levels of proinflammatory cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) in an attempt to better understand the pathogenesis of long-term skin disorders of these individuals.

    Methods: Serum concentrations of cytokines (IL-1α, IL-1β, IL-1Ra, IL-6, IL-8, IL-12 and RANTES) were measured using sandwich ELISA technique. Read More

    Friends or Foes? Host defense (antimicrobial) peptides and proteins in human skin diseases.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    Atopy (Allergy) Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
    Host defense peptides/proteins (HDPs), also known as antimicrobial peptides/proteins (AMPs), are key molecules in the cutaneous innate immune system. AMPs/HDPs historically exhibit broad-spectrum killing activity against bacteria, enveloped viruses, fungi and several parasites. Recently, AMPs/HDPs were shown to have important biological functions, including inducing cell proliferation, migration and differentiation; regulating inflammatory responses; controlling the production of various cytokines/chemokines; promoting wound healing; and improving skin barrier function. Read More

    Polyphenol-rich apple extract inhibits dexamethasone-induced sebaceous lipids production by regulating SREBP1 expression.
    Exp Dermatol 2017 Feb 13. Epub 2017 Feb 13.
    R&I Center, Cosmax Co. Ltd., Seongnam, South Korea.
    Sebum production and excretion is a primary function of the sebaceous glands, but abnormally increased sebum production is a major cause of acne vulgaris. To identify a new candidate that regulates sebum production, we investigated the possible inhibitory effects of apple polyphenols (APP) purified from unripe apples on primary cultured human sebocytes and in patients with acne vulgaris. Dexamethasone (Dex) increased lipid synthesis and expression of the sterol response element-binding protein 1 (SREBP 1) and its target enzymes, acetyl-CoA carboxylase (ACC) and fatty acid synthase (FAS), in the sebocytes. Read More

    Measuring acne using Coproporphyrin III, Protoporphyrin IX, and lesion-specific inflammation: an exploratory study.
    Arch Dermatol Res 2017 Apr 8;309(3):159-167. Epub 2017 Feb 8.
    Department of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. Read More

    A Report of Two Cases of Solid Facial Edema in Acne.
    Dermatol Ther (Heidelb) 2017 Mar 6;7(1):167-174. Epub 2017 Feb 6.
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
    Introduction: Solid facial edema (SFE) is a rare complication of acne vulgaris. To examine the clinical features of acne patients with solid facial edema, and to give an overview on the outcome of previous topical and systemic treatments in the cases so far published.

    Methods: We report two cases from Switzerland, both young men with initially papulopustular acne resistant to topical retinoids. Read More

    Acne vulgaris: Perceptions and beliefs of Saudi adolescent males.
    J Family Community Med 2017 Jan-Apr;24(1):34-43
    Department of Dermatology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia.
    Introduction: Although acne vulgaris is common in adolescents, information on their understanding of acne is minimal.

    Objectives: To evaluate the perceptions and beliefs of Saudi youth on acne.

    Materials And Methods: Three hundred twenty-nine male students (aged 13-22 years) from 6 secondary schools in the Eastern Saudi Arabia completed a self-reported questionnaire on knowledge, causation, exacerbating and relieving factors of acne. Read More

    Papular Acne Scars of the Nose and Chin: An Under-recognised Variant of Acne Scarring.
    J Cutan Aesthet Surg 2016 Oct-Dec;9(4):241-243
    Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester, United Kingdom.
    Background: Scarring following acne vulgaris is common and can be of profound psychosocial consequence.

    Aims And Objectives: We have clinically noted a variant of acne scarring, overlooked by previous categorisation schemes, which we have denominated as papular acne scars of the nose and chin. We sought to characterise these novel entities further. Read More

    Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.
    Am J Clin Dermatol 2017 Apr;18(2):169-191
    Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
    Background: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required.

    Objective: Our aim was to conduct a hybrid systematic review of the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. Read More

    Open-label, randomized, multicenter, phase III study to evaluate the safety and efficacy of benzoyl peroxide gel in long-term use in patients with acne vulgaris: A secondary publication.
    J Dermatol 2017 Feb 2. Epub 2017 Feb 2.
    Medical Writing Group, Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    An open-label, randomized, multicenter study was conducted to evaluate the safety and efficacy of long-term use of 2.5% and 5% benzoyl peroxide (BPO) gels administrated once daily for 52 weeks to Japanese patients with acne vulgaris. The efficacy of the study drugs was evaluated by counting inflammatory lesions and non-inflammatory lesions. Read More

    Acne and Rosacea.
    Dermatol Ther (Heidelb) 2017 Jan 1;7(Suppl 1):43-52. Epub 2017 Feb 1.
    University of Western Ontario, Windsor, ON, Canada.
    Acne, one of the most common skin diseases, affects approximately 85% of the adolescent population, and occurs most prominently at skin sites with a high density of sebaceous glands such as the face, back, and chest. Although often considered a disease of teenagers, acne is occurring at an increasingly early age. Rosacea is a chronic facial inflammatory dermatosis characterized by flushing (or transient facial erythema), persistent central facial erythema, inflammatory papules/pustules, and telangiectasia. Read More

    Comparison of Autologous Serum Versus Preservative Free Artificial Tear in Patients with Dry Eyes Due to Systemic Isotretinoin Therapy.
    Curr Eye Res 2017 Jan 31:1-5. Epub 2017 Jan 31.
    c Şanlıurfa Public Health Directorate , Şanlıurfa , Turkey.
    Purpose: To investigate dry eye development in the patients receiving systemic retinoic acid therapy and to compare effectiveness of Autologous Serum (AS) and preservative free artificial tear (PFAT) in the patients with dry eye disease.

    Method: This prospective, crossover, double blind study was conducted on patients who have dry eyes due to systemic isotretinoin treatment for different indications. Patients detected as having dry eye during systemic isotretinoin treatment were included to our study. Read More

    The Role of Androgens and Estrogens in Hidradenitis Suppurativa - A Systematic Review.
    Acta Dermatovenerol Croat 2016 Dec;24(4):239-249
    Peter Theut Riis, MD, Department of Dermatology University Hospital Zealand, Køgevej 7-13, 4000 Roskilde, Denmark;
    Hidradenitis suppurativa (HS) is an inflammatory skin disease. Several observations imply that sex hormones may play a role in its pathogenesis. HS is more common in women, and the disease severity appears to vary in intensity according to the menstrual cycle. Read More

    Draft Genome Sequence of an Erythromycin-Resistant Propionibacterium acnes Isolate Recovered from Folliculitis of the Scalp.
    Genome Announc 2017 Jan 26;5(4). Epub 2017 Jan 26.
    Bacteriology and Hygiene department, Nantes University Hospital, Nantes, France
    Propionibacterium acnes is now well-known and recognized for its implication in the pathogenesis of acne vulgaris. Here, we report the draft genome sequence of an erythromycin-resistant P. acnes strain isolated from a case of folliculitis of the scalp belonging to phylotype IA1 and sequence type 18 (ST18). Read More

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