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    Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.
    Nutr Metab (Lond) 2017 15;14:55. Epub 2017 Aug 15.
    Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Am Finkenhügel 7a, D-49076 Osnabrück, Germany.
    There is accumulating evidence that milk shapes the postnatal metabolic environment of the newborn infant. Based on translational research, this perspective article provides a novel mechanistic link between milk intake and milk miRNA-regulated gene expression of the transcription factor p53 and DNA methyltransferase 1 (DNMT1), two guardians of the human genome, that control transcriptional activity, cell survival, and apoptosis. Major miRNAs of milk, especially miRNA-125b, directly target TP53 and complex p53-dependent gene regulatory networks. Read More

    Dye Sensitizers for Photodynamic Therapy.
    Materials (Basel) 2013 Mar 6;6(3):817-840. Epub 2013 Mar 6.
    Fiber and Polymer Science Program, North Carolina State University, Raleigh, NC 27695-8301, USA.
    Photofrin(®) was first approved in the 1990s as a sensitizer for use in treating cancer via photodynamic therapy (PDT). Since then a wide variety of dye sensitizers have been developed and a few have been approved for PDT treatment of skin and organ cancers and skin diseases such as acne vulgaris. Porphyrinoid derivatives and precursors have been the most successful in producing requisite singlet oxygen, with Photofrin(®) still remaining the most efficient sensitizer (quantum yield = 0. Read More

    Sebocytes contribute to skin inflammation by promoting the differentiation of Th17 cells.
    Br J Dermatol 2017 Aug 11. Epub 2017 Aug 11.
    ZAUM - Center for Allergy and Environment, Technische Universität and Helmholtz Center Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
    Background: The main function of sebocytes is considered to be the lipid production for moisturizing the skin. However, it became recently apparent that sebocytes release chemokines and cytokines and respond to pro-inflammatory stimuli as well as presence of bacteria.

    Objectives: To analyze the functional communication between human sebocytes and T cells. Read More

    Propionibacterium acnes and the Th1/Th17 Axis, Implications in Acne Pathogenesis and Treatment.
    Indian J Dermatol 2017 Jul-Aug;62(4):392-394
    Department of Dermatology & STD, PGIMER and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
    Acne vulgaris is one of the most commonly seen conditions and the immunological link is a topic of active research. Recently, the Th17 pathway has been found to play a pivotal role in acne. The adaptive immune response toward Propionibacterium acnes leads to activation of Th17 axis. Read More

    The oral adverse effects of isotretinoin treatment in acne vulgaris patients: A prospective, case-control study.
    Niger J Clin Pract 2017 Jul;20(7):860-866
    Department of Operative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
    Background: Isotretinoin is the most effective therapy to treat severe acne vulgaris and its systemic adverse effects have been well documented, but little is known on dental side effects over the course of treatment.

    Objectives: This prospective case-control study aimed to evaluate the oral adverse effects of isotretinoin in Turkish patients with acne vulgaris; compare oral conditions between patients and normal controls; and investigate the association between salivary parameters and International Caries Detection and Assessment System (ICDAS) scores.

    Materials And Methods: For 6 months, the patients (n = 45) received isotretinoin daily (0. Read More

    Clinical efficacy and safety of benzoyl peroxide for acne vulgaris: Comparison between Japanese and Western patients.
    J Dermatol 2017 Aug 9. Epub 2017 Aug 9.
    Data Science Department, Maruho Co. Ltd, Kyoto, Japan.
    Benzoyl peroxide (BPO) has been well established as a common medication for acne vulgaris in many countries (e.g. in Europe and the USA), where clinical data have been accumulated over a long time. Read More

    Non-antibiotic Isotretinoin Treatment Differentially Controls Propionibacterium acnes on Skin of Acne Patients.
    Front Microbiol 2017 25;8:1381. Epub 2017 Jul 25.
    Joseph Banks Laboratories, School of Life Sciences, University of LincolnLincoln, United Kingdom.
    Emergence and potential transfer of antibiotic resistance in skin microorganisms is of current concern in medicine especially in dermatology contexts where long term treatment with antibiotics is common. Remarkably, non-antibiotic therapy in the form of isotretinoin - a non-antimicrobial retinoid is effective at reducing or eradicating the anaerobe Propionibacterium acnes which is causally involved in the complex pathogenesis of Acne vulgaris. This study measured the extent of colonization of P. Read More

    Type 2 Minocycline-induced hyperpigmentation successfully treated with the novel 755 nm picosecond alexandrite laser - a case report.
    Laser Ther 2017 Jun;26(2):137-144
    Department of Dermatology, Keio University School of Medicine.
    Background And Aim: Minocycline therapy for acne vulgaris is associated with the occasional induction of various types of unsightly and often persistent hyperpigmentation, which is frequently resistant to hydroquinone treatment. Pigment-specific lasers have achieved some success with multiple treatment sessions. Recently, the picosecond domain 755 nm alexandrite laser (ps-Alex) has attracted attention in tattoo removal. Read More

    Laser treatments of active acne.
    Lasers Med Sci 2017 Aug 4. Epub 2017 Aug 4.
    The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, 10016, USA.
    The utility of laser therapy is increasingly being recognized in the treatment of active acne vulgaris. We aimed to perform a narrative review of the medical literature on the use of laser therapy for the treatment of active acne vulgaris. We performed a PubMed literature search on September 1, 2016 using the search terms "active acne," "acne," "laser therapy," and "laser surgery. Read More

    Acne Fulminans: Treatment Experience from 26 Patients.
    Dermatology 2017 Jul 29. Epub 2017 Jul 29.
    Departments of Dermatology, Venereology, Allergology, and Immunology, Dessau Medical Center, Dessau, Germany.
    Background /Aim: Acne fulminans is a rare form of acne vulgaris with acute clinical deterioration including systemic signs. Etiopathogenesis and management remain largely unknown. Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics. Read More

    Evaluation of sequential effect of isotretinoin on the haematological parameters in patients with acne vulgaris.
    Cutan Ocul Toxicol 2017 Aug 9:1-4. Epub 2017 Aug 9.
    a Department of Dermatology, Faculty of Medicine , Celal Bayar University , Manisa , Turkey.
    Purpose: Isotretinoin is the most effective drug for acne with some side effects. Few studies exist regarding the effects of isotretinoin on haematological parameters with different results. Mostly, baseline values with a single value during or at the end of the treatment were compared. Read More

    Optimization of genotypic and biochemical methods to profile P. acnes isolates from a patient population.
    J Microbiol Methods 2017 Jul 18;141:17-24. Epub 2017 Jul 18.
    Microbiology Department, Faculty of Sciences, C/Fuentenueva s/n. University of Granada, 18071 Granada, Spain. Electronic address:
    Propionibacterium acnes is a key factor in the pathogenesis of acne vulgaris, although currently it is also being associated with medical-device infections. The aim of this work was to validate a safe and quick identification and typing of 24 clinical isolates of Propionibacterium acnes, applying a range of biochemical as well as genetic methods, and investigating the pathogenic potential to associate the different types with human health. RAPD-PCRs revealed the existence of two discernible clusters in correspondence with the phylogroups I and II, according to the PAtig gene polymorphism, leading them to be assigned as P. Read More

    Acne prevalence and associations with lifestyle: a cross-sectional online survey of adolescents/young adults in 7 European countries.
    J Eur Acad Dermatol Venereol 2017 Jul 14. Epub 2017 Jul 14.
    Pierre Fabre Dermatologie, Les Cauquillous, Lavaur, 81500, France.
    Background: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations.

    Objective: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne.

    Methods: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category. Read More

    The effect of personal, familial, and enviroinmental characteristics on acne vulgaris: a prospective, multicenter, case controlled study from Turkey.
    G Ital Dermatol Venereol 2017 Jul 11. Epub 2017 Jul 11.
    Ankara University, School of Medicine, Department of Dermatology, Ankara, Turkey.
    Background: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity.

    Methods: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. Read More

    Microneedling: Where do we stand now? A systematic review of the literature.
    J Plast Reconstr Aesthet Surg 2017 Jun 17. Epub 2017 Jun 17.
    Department of Plastic and Reconstructive Surgery - Burn Center, University Hospital of Ghent, De Pintelaan 185, 9000 Ghent, Belgium.
    Background: Patients who suffer from scars or wrinkles have several therapeutic options to improve the appearance of their skin. The available treatment modalities that provide desirable results are often overtly invasive and entail a risk of undesirable adverse effects. Microneedling has recently emerged as a non-ablative alternative for treating patients who are concerned with the aesthetic changes that result from injury, disease or ageing. Read More

    Treatment Response With Once-Daily Topical Dapsone Gel, 7.5% for Acne Vulgaris: Subgroup Analysis of Pooled Data from Two Randomized, Double-Blind Stu.
    J Drugs Dermatol 2017 Jun;16(6):591-598

    BACKGROUND: Acne vulgaris has varying physical and psychological effects in men and women of different ages, races, and ethnicities.

    OBJECTIVE: This analysis assessed the relationship of age, sex, and race to treatment response with once-daily topical dapsone gel, 7.5%. Read More

    Adapalene/Benzoyl Peroxide Gel 0.3%/2.5%: Effective Acne Therapy Regardless of Age or Gender.
    J Drugs Dermatol 2017 Jun;16(6):582-589

    BACKGROUND: Acne vulgaris affects a diverse group of people, and there is an increasingly wide variety of acne treatments. Because of the many options, clinicians have a better ability to individualize treatment; however, achieving optimal results relies on understanding how various agents perform in specific population segments. Fixed-combination adapalene plus benzoyl peroxide (A/BPO) is a first-line recommended acne therapy and is available in two adapalene concentrations (0. Read More

    The Efficacy and Safety of Azelaic Acid 15% Foam in the Treatment of Truncal Acne Vulgaris.
    J Drugs Dermatol 2017 Jun;16(6):534-538

    INTRODUCTION: Truncal acne is often associated with facial acne, but there are fewer options for an effective topical treatment on the trunk. Given the advent of foam formulations with enhanced percutaneous absorption and convenient application due to easy spreadability on skin, the previously held idea that effective treatment of truncal acne requires oral treatment is challenged. Azelaic acid cream has been previously approved for acne vulgaris, thus azelaic acid foam may be a viable treatment option for truncal acne. Read More

    Trends in prescribing behavior of systemic agents used in the treatment of acne among dermatologists and nondermatologists: A retrospective analysis, 2004-2013.
    J Am Acad Dermatol 2017 Sep 1;77(3):456-463.e4. Epub 2017 Jul 1.
    Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania; Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
    Background: Despite recommendations to limit the use of oral antibiotics and increasing support for hormonal agents in the treatment of acne, it is unclear whether there have been any significant changes in practice patterns.

    Objective: To characterize changes in prescribing behavior for systemic agents in the treatment of acne in the United States between 2004 and 2013.

    Methods: We conducted a retrospective analysis using the OptumInsight Clinformatics DataMart (Optum, Eden Prairie, MN). Read More

    Psychosocial Impact of Postinflammatory Hyperpigmentation in Patients with Acne Vulgaris.
    J Clin Aesthet Dermatol 2017 May 1;10(5):18-23. Epub 2017 May 1.
    Department of Dermatology, Saint Louis University School of Medicine, Saint Louis, Missouri.
    Background: Acne vulgaris is a common, often socially distressing skin condition primarily seen in young adults. Quality of life studies have shown that people with acne are more introverted with increased social setting anxiety compared to a control group. Unfortunately, patients with acne may have residual postinflammatory hyperpigmentation, amplifying impaired psychosocial effects. Read More

    Pressure- and dose-controlled transcutaneous pneumatic injection of hypertonic glucose solution for the treatment of atrophic skin disorders.
    J Cosmet Laser Ther 2017 Jun 30:1-6. Epub 2017 Jun 30.
    a Department of Dermatology and Cutaneous Biology Research Center, International St. Mary's Hospital , Catholic Kwandong University, College of Medicine , Incheon , Republic of Korea.
    Background: Needleless transcutaneous pneumatic injections (TPIs) are a minimally invasive way to deliver the solution into the skin for therapeutic purposes. The suggested action mechanisms of TPI therapy include mechanical stimulation, immediate tissue shrinkage and late wound healing.

    Methods: Thirteen Korean patients were treated with TPI for atrophic skin disorders, including acne scars, striae albae, post-furuncle, or carbuncle scars, and horizontal wrinkles with lipoatrophy. Read More

    Olumacostat Glasaretil, a Promising Topical Sebum-Suppressing Agent that Affects All Major Pathogenic Factors of Acne Vulgaris.
    J Invest Dermatol 2017 Jul;137(7):1405-1408
    Department of Dermatology, Environmental Medicine, Health Theory, Faculty of Human Sciences, University of Osnabrück, Osnabrück, Germany. Electronic address:
    Hunt et al. show that olumacostat glasaretil, an inhibitor of acetyl coenzyme A carboxylase, reduces saturated and monounsaturated fatty acyl chains in sebaceous lipids. Topical olumacostat glasaretil application decreases hamster ear sebaceous gland size and shows efficacy in treating patients with acne vulgaris. Read More

    Isotretinoin and lymecycline treatments modify the skin microbiota in acne.
    Exp Dermatol 2017 Jun 21. Epub 2017 Jun 21.
    Department of Dermatology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    Oral retinoids and tetracyclines have a major role in acne treatment. Here, we report for the first time the effect of isotretinoin and lymecycline therapy on the skin microbiota in cheek, back and armpit swab samples of acne vulgaris patients using 16S ribosomal RNA (16S rRNA) gene amplicon sequencing. Propionibacterium acnes was the most common in sebaceous areas of healthy and untreated acne skin and more abundant in back than cheek samples. Read More

    Oxidative stress and psychiatric morbidity in patients with facial acne.
    J Cosmet Dermatol 2017 Jun 20. Epub 2017 Jun 20.
    Faculty of Medicine, Department of Neuropsychiatry, Assiut University, Assiut, Egypt.
    Background: Acne vulgaris is a common cosmetic problem that is frequently associated with psychosocial disturbances as well as increased oxidative stress. However, oxidative stress and psychological aspects have been studied separately in acne.

    Objective: To evaluate the relationships between oxidative stress, anxiety, depression, and quality of life in acne patients. Read More

    Anti-acne drugs in phase 1 and 2 clinical trials.
    Expert Opin Investig Drugs 2017 Jul 19;26(7):813-823. Epub 2017 Jun 19.
    c Department of Venerology and Dermatology , Otto von Guericke University Magdeburg , Magdeburg , Germany.
    Introduction: Despite the impressive increase of knowledge on acne etiology accumulated during the last 20 years, few efforts have been overtaken to introduce new therapeutic regiments targeting the ideal treatment of acne. The increasing emergence of microbial resistance associated with antibiotics, teratogenicity, particularly associated with systemic isotretinoin, and the need for an adverse drug profile, which can be tolerated by the patient, make the need of new pathogenesis relevant anti-acne agents an emerging issue. Areas covered: A search for phase 1 and 2 acne treatment trials in the US National Institutes of Health database of clinical trials and the European Medicines Agency database with the key words 'acne' and 'treatment' was carried out, on 6 January 2017. Read More

    Effects of herbal medicine for dysmenorrhea treatment on accompanied acne vulgaris: a study protocol for a randomized controlled trial.
    BMC Complement Altern Med 2017 Jun 17;17(1):318. Epub 2017 Jun 17.
    Department of Ophthalmology & Otolaryngology & Dermatology of Korean Medicine, College of Korean Medicine, Kyung Hee University, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea.
    Background: The incidence of preadolescent acne among women is increasing. Acne deteriorates the quality of life; conventional treatment options are limited and have not been effective against acne, particularly acne associated with menstruation. Despite evidence that acne associated with menstruation abnormalities naturally improves when menstruation recovers to normal, there have only been few studies on the effects of dysmenorrhea treatment on acne. Read More

    Antimicrobial susceptibility and phylogenetic analysis of Propionibacterium acnes isolated from acne patients in Japan between 2013 and 2015.
    J Dermatol 2017 Jun 17. Epub 2017 Jun 17.
    Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
    The prevalence of antimicrobial-resistant Propionibacterium acnes strains isolated from acne patients has been increasing in Japan. Here, to estimate the current resistance rate, we tested antimicrobial susceptibility among P. acnes from acne patients having visited a specialized dermatology clinic between 2013 and 2015. Read More

    Evidence-based recommendations for the management of acne fulminans and its variants.
    J Am Acad Dermatol 2017 Jul;77(1):109-117
    University of California, San Diego, California; Rady Children's Hospital-San Diego, San Diego, California.
    Background: Acne fulminans (AF) is a severe variant of inflammatory acne. It typically manifests as an explosive worsening and ulceration of skin lesions, and can be associated with systemic symptoms. However, there is a paucity of evidence-based information and no clear guidelines concerning the classification and treatment of AF. Read More

    Epidemiology of Acne Vulgaris in 18-Year-Old Male Army Conscripts in a South Brazilian City.
    Dermatology 2017 Jun 14. Epub 2017 Jun 14.
    Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
    Background: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors.

    Objective: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. Read More

    Differences in Dietary Glycemic Load and Hormones in New York City Adults with No and Moderate/Severe Acne.
    J Acad Nutr Diet 2017 Jun 9. Epub 2017 Jun 9.
    Background: Glycemic index (GI) and glycemic load (GL) may be implicated in acne pathogenesis.

    Objective: This cross-sectional study examined differences between GI/GL and biological factors associated with acne among adults with and without moderate/severe acne. Secondary objectives included examining differences between food-aggravated acne beliefs and acne-specific quality of life among adults with and without moderate/severe acne. Read More

    A Polycation Antimicrobial Peptide Mimic without Resistance Buildup against Propionibacterium Acnes.
    Macromol Biosci 2017 Jun 12. Epub 2017 Jun 12.
    Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, 23219, USA.
    A preliminary study is reported for a polycation antimicrobial peptide (AMP) mimic against Propionibacterium acnes, which is associated with acne vulgaris, a common skin condition. Antibiotics are commonly used against P. acnes but buildup of resistance is well-known. Read More

    Mechanistic Analysis of Human Skin Distribution and Follicular Targeting of Adapalene-Loaded Biodegradable Nanospheres With an Insight Into Hydrogel Matrix Influence, In Vitro Skin Irritation, and In Vivo Tolerability.
    J Pharm Sci 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, Granada University, Granada, Spain.
    This work aimed at the development of a biocompatible, non-oily nanomedicine for follicular delivery of adapalene (AD) ameliorating its irritation potential for convenient localized topical treatment of acne vulgaris. AD was efficiently incorporated into poly-ε-caprolactone nanospheres (NS) with an encapsulation efficiency of 84.73% ± 1. Read More

    A Diagnostic Approach to Recurrent Orofacial Swelling: A Retrospective Study of 104 Patients.
    Mayo Clin Proc 2017 Jul 7;92(7):1053-1060. Epub 2017 Jun 7.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Objective: To identify patients evaluated in an outpatient setting at our institution with a presentation of recurrent orofacial swelling and to review the spectrum of causes to outline a diagnostic approach.

    Patients And Methods: A retrospective study of 104 patients with more than 1 episode of orofacial swelling lasting for more than 5 days identified through a keyword search of the electronic health record from January 2, 2000, through July 5, 2011.

    Results: Patients were categorized according to final cause of orofacial swelling: idiopathic orofacial granulomatosis, solid facial edema due to rosacea and acne vulgaris, Crohn disease, contact dermatitis, sarcoidosis, exfoliative cheilitis, lichen planus, actinic cheilitis, cheilitis glandularis, lymphedema, miscellaneous, and multifactorial. Read More

    Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic-Resistant Acne-Related Bacteria.
    Mar Drugs 2017 Jun 8;15(6). Epub 2017 Jun 8.
    Department of Food Science and Technology, Pukyong National University, Busan 48547, Korea.
    The object of this study was to discover an alternative therapeutic agent with fewer side effects against acne vulgaris, one of the most common skin diseases. Acne vulgaris is often associated with acne-related bacteria such as Propionibacteriumacnes, Staphylococcusepidermidis, Staphylococcusaureus, and Pseudomonasaeruginosa. Some of these bacteria exhibit a resistance against commercial antibiotics that have been used in the treatment of acne vulgaris (tetracycline, erythromycin, and lincomycin). Read More

    Genetic architecture of acne vulgaris.
    J Eur Acad Dermatol Venereol 2017 Jun 7. Epub 2017 Jun 7.
    Department of Dermatology, University Hospital of Zurich, Gloriastrasse 31, 8091, Zurich, Switzerland.
    Background: Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen-induced increased sebum production, altered keratinization and inflammation.

    Objective: Here we review our current understanding of the genetic architecture of this intriguing disease and want to show rare and corresponding diseases like PCOS with acne vulgaris.

    Methods: We conducted a data research identifying genome-wide association studies (GWAS), candidate genes studies as case reports for acne vulgaris. Read More

    Potential of IL-1, IL-18 and Inflammasome Inhibition for the Treatment of Inflammatory Skin Diseases.
    Front Pharmacol 2017 22;8:278. Epub 2017 May 22.
    Department of Dermatology, University Hospital ZurichZurich, Switzerland.
    In 2002, intracellular protein complexes known as the inflammasomes were discovered and were shown to have a crucial role in the sensing of intracellular pathogen- and danger-associated molecular patterns (PAMPs and DAMPs). Activation of the inflammasomes results in the processing and subsequent secretion of the pro-inflammatory cytokines IL-1β and IL-18. Several autoinflammatory disorders such as cryopyrin-associated periodic syndromes and Familial Mediterranean Fever have been associated with mutations of genes encoding inflammasome components. Read More

    Why Topical Retinoids Are Mainstay of Therapy for Acne.
    Dermatol Ther (Heidelb) 2017 Jun 5. Epub 2017 Jun 5.
    Gwinnett Dermatology, PC, and Gwinnett Clinical Research Center, Inc., Snellville, GA, USA.
    Acne-focused dermatology expert groups have consistently recommended that most patients with acne be treated with a combination of topical retinoid and antimicrobial therapy. This is based on clinical data as well as evidence that these drug classes have different and complementary mechanisms of action that target multiple aspects of acne's complex pathophysiology. Recent evidence-based guidelines for acne, including those from the American Academy of Dermatology (AAD) and the European Dermatology Forum (EDF), have agreed that retinoids have an essential role in this widespread disease. Read More

    In vitro modeling of unsaturated free fatty acid-mediated tissue impairments seen in acne lesions.
    Arch Dermatol Res 2017 May 31. Epub 2017 May 31.
    Department of Skin Biology and Pharmacology, The Johnson & Johnson Skin Research Center, Johnson & Johnson Consumer Inc., 199 Grandview Road, Skillman, NJ, 08558, USA.
    Acne vulgaris is a disease of pilosebaceous units with multifactorial pathogenesis, including hyperkeratinization, increased sebum secretion, and inflammation. Recently, it was suggested that acne subjects may have also impaired skin barrier. We hypothesized that excess unsaturated free fatty acids (UFFA) present in the sebum may cause barrier impairment associated with increased follicular stratum corneum (SC) thickening and inflammation seen in acne. Read More

    Endocrine disorders and hormonal therapy for adolescent acne.
    Curr Opin Pediatr 2017 Aug;29(4):455-465
    Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA.
    Purpose Of Review: Acne vulgaris is a global disease with increasing prevalence in adolescents. It has a profound impact on their quality of life, especially when endocrine disorders are also involved. Recent concerns regarding antibiotic stewardship, failures with antibiotic usage, and the development of antibiotic-resistant Propionibacterium acnes have led clinicians to consider other therapeutic options for acne treatment. Read More

    The age-old problem of acne.
    Int J Womens Dermatol 2017 Jun 2;3(2):71-76. Epub 2016 Dec 2.
    Department of Dermatology, Warwick Hospital, Lakin Road, Warwick, United Kingdom.
    Acne vulgaris is one of the top three most commonly encountered dermatological problems worldwide in both primary and secondary care. Acne diagnosis and treatment date back to ancient Greek and Egyptian times. This article explores acne through the ages and discusses past theories on etiology and treatment with particular focus on the discovery of retinoids and their impact on women's health. Read More

    Acne: morphologic and vascular study of lesions and surrounding skin by means of optical coherence tomography.
    J Eur Acad Dermatol Venereol 2017 May 30. Epub 2017 May 30.
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.
    Background: Acne vulgaris is a disease of the pilosebaceous unit, characterized by hyper-keratinization process, comedos formation and inflammatory reactions.

    Objective: The definition of the morphology and the vascularization of acne lesions by means of dynamic optical coherence tomography (D-OCT), to non-invasively define the alterations occurring during the acne development and patient therapeutic management.

    Methods: A set of standardized clinical pictures and D-OCT images were acquired from 114 acne lesions of 31 volunteers, presenting mild to moderate acne and evaluated by experts. Read More

    Microneedles in the clinic.
    J Control Release 2017 Aug 23;260:164-182. Epub 2017 May 23.
    Department of Pharmacy, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Hyderabad 500078, India. Electronic address:
    In general, there is a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical and biological properties, and their performance. Reduction in the dimensions of hypodermic needle to micron-scale size has gained tremendous interest among researchers. Research efforts and publications investigating the design, development and applications of microneedles have exponentially increased in the recent years. Read More

    Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris.
    An Bras Dermatol 2017 Mar-Apr;92(2):212-216
    Department of Biomedical Sciences and Therapeutics, Faculty of Medicine and Health Sciences, University Malaysia Sabah - Sabah, Malaysia.
    Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Read More

    Dermatology in Ghana: a retrospective review of skin disease at the Korle Bu Teaching Hospital Dermatology Clinic.
    Pan Afr Med J 2017 3;26:125. Epub 2017 Mar 3.
    The Ronald Perelman Department of Dermatology, New York University School of Medicine, USA.
    Introduction: Ghana is currently developing its provision of dermatology services. Epidemiologic studies of the skin diseases seen by Ghanaian dermatologists are needed to guide these efforts. We aimed to describe the skin conditions seen by and management practices of Ghanaian dermatologists in a specialized clinic. Read More

    A Retrospective Study of Multiple Sequential Light and Laser Sources to Activate Aminolevulinic Acid in the Treatment of Acne Vulgaris.
    Skinmed 2017 1;15(2):105-111. Epub 2017 Apr 1.
    Goldman, Butterwick, Fitzpatrick, Groff, and Fabi: Cosmetic Laser Dermatology, San Diego, CA.
    Reports of the sequential use of multiple light and laser sources for topical 5-aminolevulinic acid (ALA) activation in photodynamic therapy (PDT) of inflammatory acne vulgaris are lacking. The authors sought to retrospectively compare field-directed ALA-PDT with blue light only, blue light + pulsed dye laser (PDL), blue light + intense pulsed light (IPL), blue light + PDL + IPL, or blue light + red light + PDL + IPL for inflammatory acne of the face or upper trunk. Results showed a trend toward greater patient-reported improvement with comparable tolerability using multiple, sequential light sources in ALA-PDT for acne vulgaris, albeit not statistically significant. Read More

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