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    Evaluation of Adolescents Diagnosed with Acne Vulgaris for Quality of Life and Psychosocial Challenges.
    Indian J Dermatol 2018 Mar-Apr;63(2):131-135
    Department of Child and Adolescent Psychiatry, Mardin Public Hospital, 47200 Mardin, Turkey.
    Background: Acne vulgaris is a common skin condition which affects most adolescents. It has a major impact on quality of life and psychosocial well-being.

    Aims: The aims of the study were to examine the psychosocial effects of acne on adolescents and changes in quality of life, and to reveal any difference in the possible effect between genders. Read More

    A Low Glycemic Index and Glycemic Load Diet Decreases Insulin-like Growth Factor-1 among Adults with Moderate and Severe Acne: A Short-Duration, 2-Week Randomized Controlled Trial.
    J Acad Nutr Diet 2018 Apr 21. Epub 2018 Apr 21.
    Background: A high glycemic index (GI) and glycemic load (GL) diet may stimulate acne proliferative pathways by influencing biochemical factors associated with acne. However, few randomized controlled trials have examined this relationship, and this process is not completely understood.

    Objective: This study examined changes in biochemical factors associated with acne among adults with moderate to severe acne after following a low GI and GL diet or usual eating plan for 2 weeks. Read More

    Tumor necrosis factor α-308 G/A and interleukin 1 β-511 C/T gene polymorphisms in patients with scarring acne.
    J Cosmet Dermatol 2018 Apr 19. Epub 2018 Apr 19.
    Pediatric Immunology, Hacettepe University School of Medicine, Ankara, Turkey.
    Background: Acne is a chronic inflammatory skin disorder which may heal with scarring. Tumor necrosis factor alpha (TNF α) and interleukin 1 β (IL-1β) are considered as the main responsible proinflammatory mediators of acne pathogenesis. Oversecretion of these cytokines was found to be associated with TNF α-308 G>A and IL-1β-511 CRead More

    Treatment of atrophic acne scarring with fractional micro-plasma radio-frequency in Chinese patients: A prospective study.
    Lasers Surg Med 2018 Apr 16. Epub 2018 Apr 16.
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China.
    Background: Acne scarring is a common disfiguring sequela of acne vulgaris which can lead to serious psychosocial problems and have a negative effect on patients' quality of life. Although a variety of approaches can be used to treat atrophic acne scars, disadvantages such as long-healing time, dyspigmentation, infections, and prolonged erythema make these treatments unsatisfactory especially for Asians. Fractional micro-plasma radio-frequency is a novel technology that produces minor ablation to the epidermis to promote rapid re-epithelialization, while the radio-frequency evoked thermal effect can stimulate regeneration and remodeling of dermal fibroblasts. Read More

    A comparison of combined oral contraceptives containing chlormadinone acetate versus drospirenone for the treatment of acne and dysmenorrhea: a randomized trial.
    Contracept Reprod Med 2018 10;3. Epub 2018 Apr 10.
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330 Thailand.
    Background: Oral contraceptives (OCs), aside from contraceptive efficacy, have been widely known for their non-contraceptive benefits. Different progestogens component of the OCs have been shown to improve the skin, hair, menstrual cycle related disorders and dysmenorrhoeic pain. Thus, we compared the efficacy of OCs containing ethinyl estradiol (EE) and chlormadinone acetate (CMA) versus OCs containing EE and drospirenone (DRSP) for the treatment of acne and dysmenorrhea. Read More

    Efficacy and Safety Evaluation of High-density Intense Pulsed Light in the Treatment of Grades II and IV Acne Vulgaris as Monotherapy in Dark-skinned Women of Child Bearing Age.
    J Clin Aesthet Dermatol 2018 Apr 1;11(4):43-48. Epub 2018 Apr 1.
    Dr. Deshpande is with the Maharashtra Medical Foundation Joshi Hospital in Pune, India.
    Acne vulgaris is a self-limiting, chronic inflammatory disorder of the pilosebaceous unit characterized by exacerbations and remissions. It is often the early manifestation of puberty, and in girls it appears relatively early. In women, acne tends to become aggravated during the menstrual period, pregnancy, and in those who are on progesterone. Read More

    S1-Leitlinie - Dermatosen bei dermaler Lymphostase.
    J Dtsch Dermatol Ges 2018 Apr;16(4):512-524
    ehemalige Klinik Sanaderm für Dermatologie, Allergologie, Phlebologie, Lymphologie, Bad Mergentheim.
    Das Ziel dieser S1-Leitlinie ist es, aktuelles Wissen über dermatologisch relevante Krankheitsbilder bei lokal begrenzter dermaler Lymphostase an allen Lokalisationen des Hautorgans zu vermitteln, um diese frühzeitig zu erkennen, diagnostisch zu sichern und gezielt zu behandeln. Wann immer möglich, sollte diese Therapie anhand klar definierter Algorithmen stadiengerecht erfolgen. Die im klinischen Alltag häufig auftauchenden differenzialdiagnostischen und therapeutischen Fragen lassen eine aktuelle Leitlinie notwendig erscheinen. Read More

    An Automatic Diagnosis Method of Facial Acne Vulgaris Based on Convolutional Neural Network.
    Sci Rep 2018 Apr 11;8(1):5839. Epub 2018 Apr 11.
    Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, HangZhou, 310027, China.
    In this paper, we present a new automatic diagnosis method for facial acne vulgaris which is based on convolutional neural networks (CNNs). To overcome the shortcomings of previous methods which were the inability to classify enough types of acne vulgaris. The core of our method is to extract features of images based on CNNs and achieve classification by classifier. Read More

    Optimizing the use of topical retinoids in Asian acne patients.
    J Dermatol 2018 Apr 3. Epub 2018 Apr 3.
    Jose R. Reyes Memorial Medical Center, Manila, Philippines.
    Acne vulgaris is a common disease among people in Asia. International guidelines and treatment recommendations emphasize the central role of topical retinoids in the management of acne. However, topical retinoids remain underutilized in clinical practise, which may be in part due to fear of retinoid-associated dermatitis/lack of experience, particularly in Asian patients. Read More

    Indicators of phagocytosis in women with acne during comprehensive treatment that included immunotherapy and probiotics.
    Wiad Lek 2018 ;71(1 pt 2):144-147
    Danylo Halytsky Lviv National Medical University, Lviv, Ukraine.
    Objective: Introduction: Acne is one of the most common dermatological diseases. It may have a chronic course, leaving permanent marks, and in last years has been tending to have more and more severe clinical course with widespread skin lesions. According to recent studies, the development of acne is due to the combined effect of endogenous and exogenous factors, among which endocrine diseases (quite a significant aspect), disorders of metabolic processes, reduced systemic immunity and phagocytic ability of mononuclear phagocytes and granulocytes at various stages of phagocytosis of pyogenic cocci, which contributes to more severe clinical course, and frequent relapse of this diseases. Read More

    Emerging Therapies for Acne Vulgaris.
    Am J Clin Dermatol 2018 Mar 29. Epub 2018 Mar 29.
    Department of Dermatology, University of California, Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
    As we gain a greater understanding of acne pathogenesis, both new agents as well as new uses for established drugs are being considered for the treatment of acne vulgaris. Multiple clinical trials assessing new formulations or combinations of established acne treatments have been conducted, and novel uses of antimicrobials such as modified diallyl disulfide oxide and nitric oxide are being assessed in clinical trials. There are also a multitude of new therapies currently being studied that target the inflammatory cascade of acne pathogenesis, including sebosuppressive and anti-inflammatory phytochemicals, and  small molecule inhibitors targeting sebaceous glands and enzymes, among others. Read More

    No evidence for follicular keratinocyte hyperproliferation in acne lesions as compared to autologous healthy hair follicles.
    Exp Dermatol 2018 Mar 27. Epub 2018 Mar 27.
    Department of Pathology, Umeå University, Umeå.
    Abnormal hyperkeratinization in sebaceous hair follicles has long been believed to play an important role in acne pathogenesis. Several early reports purported to provide histological evidence for hyperproliferation of keratinocytes in acne lesions by showing a higher expression of the Ki67 as well as certain keratins. The evidence is, however, not robust and a number of methodological and technical pitfalls can be identified in these studies. Read More

    Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients.
    G Ital Dermatol Venereol 2018 Apr;153(2):161-164
    Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy.
    Background: Acne vulgaris is a chronic inflammatory skin disease that manifests as open and closed comedones as well as inflammatory papules, pustules, and nodules localized on face and trunk. Oral isotretinoin demonstrated to be effective in controlling seborrhea, inflammation, Propionibacterium Acnes hyperproliferation and reducing scarring, nevertheless muco-cutaneous side effects, particularly dryness, itching, bruising are commonly seen in patients under treatment with isotretinoin reducing the compliance to the treatment. We conducted a randomized controlled trial to evaluate the efficacy of a cream compound formulated in order to reduce the oral isotretinoin side effects (redness, dryness, itching) in patients affected by severe acne of the face. Read More

    Phototherapy with Light Emitting Diodes: Treating a Broad Range of Medical and Aesthetic Conditions in Dermatology.
    J Clin Aesthet Dermatol 2018 Feb 1;11(2):21-27. Epub 2018 Feb 1.
    Dr. Ablon is with the Ablon Skin Institute and Research Center in Manhattan Beach, California.
    Within the field of dermatology, advances in the use of light emitting diodes (LEDs) have led to their clinical application for a variety of medical and cosmetic uses. Of note, one phototherapy device has demonstrated beneficial effects over a range of clinical applications (Omnilux™; GlobalMed Technologies, Glen Ellen, California). The study included a literature review of published studies. Read More

    Efficacy and Safety of Sarecycline, a Novel, Once-Daily, Narrow Spectrum Antibiotic for the Treatment of Moderate to Severe Facial Acne Vulgaris: Results of a Phase 2, Dose-Ranging Study.
    J Drugs Dermatol 2018 Mar;17(3):333-338
    Background: There is a need for new oral antibiotics for acne with improved safety profiles and targeted antibacterial spectra. Sarecycline is a novel, tetracycline-class antibiotic specifically designed for acne, offering a narrow spectrum of activity compared with currently available tetracyclines, including less activity against enteric Gram-negative bacteria. This phase 2 study evaluated the efficacy and safety of three doses of sarecycline for moderate to severe facial acne vulgaris. Read More

    Efficacy and Safety of Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel Plus Oral Doxycycline in Subjects With Severe Inflammatory Acne Who Are Candidates for Oral Isotretinoin.
    J Drugs Dermatol 2018 Mar;17(3):264-273
    Introduction: Acne treatment guidelines suggest a combination approach with topical therapy including a topical retinoid, benzoyl peroxide and an oral antibiotic, or oral isotretinoin (OI), as first-line treatment options for severe acne vulgaris (AV). This study evaluated the efficacy and safety of a daily regimen of 0.3% adapalene and 2. Read More

    A comparative review of the isotretinoin pregnancy risk management programs across four continents.
    Int J Dermatol 2018 Mar 6. Epub 2018 Mar 6.
    The University of Sydney, Sydney, NSW, Australia.
    Isotretinoin has revolutionized the treatment of severe acne vulgaris, a condition which if left untreated may result in significant socio-psychological implications for those affected. Timely access to isotretinoin therapy is important to avoid the risks of potential physical and emotional scarring. However, due to its high risks of teratogenicity, isotretinoin must be used with care in females of childbearing potential. Read More

    IL1A (-889) gene polymorphism is associated with the effect of diet as a risk factor in Acne Vulgaris.
    J Cosmet Dermatol 2018 Mar 1. Epub 2018 Mar 1.
    Resident at Hehia Central Hospital, Benha, Egypt.
    Background: Despite the several studies suggesting the genetic basis of acne vulgaris, the exact genetic architecture of this very common condition is not yet clear.

    Aim Of The Work: This study aimed to investigate the association between IL-1A (-889) gene polymorphism and acne vulgaris in a sample of patients.

    Subjects And Method: Blood samples from 100 patients with acne vulgaris and 100 healthy age, sex, and BMI matched controls were obtained. Read More

    C1-C2 arthrodesis after spontaneous spondylodiscitis: Case report and literature analysis.
    Surg Neurol Int 2018 22;9:14. Epub 2018 Jan 22.
    GSpine4, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
    Background: () is a microaerophilic anaerobic Gram-positive rod responsible for acne vulgaris. Although it is often considered to be a skin contaminant, it may act as a virulent agent in implant-associated infections. Conversely, spontaneous infectious processes have been rarely described. Read More

    ADT-G as a promising biomarker for peripheral hyperandrogenism in adult female acne.
    Dermatoendocrinol 2017 13;9(1):e1361571. Epub 2017 Oct 13.
    Escola Paulista de Medicina-Universidade Federal de São Paulo (EPM-Unifesp), Brazil.
    Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and present some clinical differences compared to adolescent acne. Read More

    Cleanser use could decrease numbers of Demodex Folliculorum in mild to moderate acne patients.
    Dermatoendocrinol 2017 4;9(1):e1348444. Epub 2017 Oct 4.
    Department of Dermatology, Research and Studies Center on the Integument (CERT), Clinical Investigation Center (CIC INSERM 1431), Besançon University Hospital; INSERM UMR1098, FED4234 IBCT, University of Franche-Comté, Besançon, France.
    This study was to verify if the skin cleanser could help decrease the infection ratio of Demodex Folliculorum in acne patients. 132 participants with mild to moderate vulgaris acne participated in this monocentric, prospective, double-blind study. Dermatologists grading and Standardized Skin Surface Biopsy were performed in baseline and after using cleanser only 7 d later. Read More

    The effect on acne quality of life of topical azelaic acid 15% gel versus a combined oral contraceptive in adult female acne: A randomized trial.
    Dermatoendocrinol 2017 13;9(1):e1361572. Epub 2017 Oct 13.
    Escola Paulista de Medicina - Universidade Federal de São Paulo (EPM-Unifesp), Brazil.
    Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. Recent studies have shown an increasing number of cases of acne in adult women. These cases are predominantly normoandrogenic and have show some clinical differences compared to adolescent acne. Read More

    Modulation of Toll Like Receptor-2 on sebaceous gland by the treatment of adult female acne.
    Dermatoendocrinol 2017 4;9(1):e1361570. Epub 2017 Oct 4.
    Department of Dermatology, Department of Preventive Medicine, Universidade Federal de São Paulo, São Paulo, Brazil.
    Adult female acne is a chronic inflammatory, immune-mediated disease that affects the pilosebaceous unit in women in their 20s to 40s, and is considered different from acne vulgaris. is recognized by TLR-2, resulting in activation of this receptor and an inflammatory response through the B pathway. This therapeutic, interventional, open, randomized, evaluator-blinded and comparative trial included 38 adult women with moderate facial acne and 10 age-matched controls, all aged between 26 and 44 years. Read More

    Special types of folliculitis which should be differentiated from acne.
    Dermatoendocrinol 2017 27;9(1):e1356519. Epub 2017 Sep 27.
    Department of Dermatology, Beijing Hospital, National Center of Gerontology, Dongdan, Dongcheng District, Beijing, China.
    Because both acne vulgaris and folliculitis can present as inflammatory erythematous papules, pustules or nodules, they are often hard to distinguish. The importance to distinguish between these 2 shall be stressed as their pathogenesis and therapies are different and misdiagnosis or missed diagnosis may lead to improper treatment. We will introduce several special types of folliculitis that should be differentiated from acne to increase our knowledge of the disorders with an acne-like manifestation. Read More

    Dermatological indications for the use of isotretinoin beyond acne.
    J Dermatolog Treat 2018 Mar 14:1-8. Epub 2018 Mar 14.
    b Dermatological Surgery & Laser Unit , St John's Institute of Dermatology, Guy's Cancer Centre, Guy's and St Thomas' NHS Foundation Trust , London , UK.
    While the use of isotretinoin has revolutionized the treatment of acne vulgaris, isotretinoin is increasingly recognized as a useful therapeutic option for many other cutaneous conditions. We review the evidence underlying the use of isotretinoin for a variety of dermatological indications including hidradenitis suppurativa, sebaceous gland pathology, rosacea, scarring alopecia, cosmetic dermatology, and non-melanoma skin cancer prophylaxis amongst other uses, and thus consider alternative uses within dermatology practice. The studies found benefit of isotretinoin, however most trials lacked statistical power and in many cases the use was limited to case series. Read More

    Clinical significance of neutrophil gelatinase-associated lipocalin and galectin-7 in tape-stripped stratum corneum of acne vulgaris.
    J Dermatol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Dermatology, Toho University Ohashi Medical Center, Tokyo, Japan.
    The usefulness of stratum corneum neutrophil gelatinase-associated lipocalin and stratum corneum galectin-7 as biomarkers of acne vulgaris was studied. A comparison of neutrophil gelatinase-associated lipocalin levels on the cheeks of patients with acne vulgaris at the start of the study and at the time of symptom improvement showed a significant decrease. On the other hand, the galectin-7 levels at the time of symptom improvement were significantly higher than those at the start of the study. Read More

    An confocal Raman spectroscopic investigation of salicylic acid penetration: Variation with formulation parameters.
    J Cosmet Sci 2017 Jan/Feb;68(1):55-58
    Consumer Science, Ashland Specialty Ingredients.
    Salicylic acid (SA) is widely used in leave-on antiacne formulations, typically at a 2% level. As a β-hydroxy acid, it is a milder active ingredient than either α-hydroxy acids or benzoyl peroxide. SA is a keratolytic agent, a bacteriocide, and a comedolytic agent. Read More

    Evaluation the efficacy of trichloroacetic acid (TCA) 33% in treatment of oral retinoid-induced cheilitis compared with placebo (Vaseline): a randomized pilot study.
    J Dermatolog Treat 2018 Mar 6:1-4. Epub 2018 Mar 6.
    b Kassir Dermatology , Dallas , TX , USA.
    Background: Oral Isotretinoin (13-cis-retinoic acid) is a gold standardtreatment for severe forms of acne with cheilitis as a most frequent complication. We designed this novel study to investigate the therapeutic effect of trichloroacetic acid (TCA) 33% as compared with placebo to treat cheilitis.

    Methods: In this pilot study, 90 acne vulgaris patients between 18 and 50 years, who referred dermatologic clinic with cheilitis, were assigned to either case (TCA) or control (Vaseline) group using permuted-block randomization from 2013 to 2015 with data analysis in 2016. Read More

    Efficacy, Safety, and Tolerability of Topical Dapsone Gel, 7.5% for Treatment of Acne Vulgaris by Fitzpatrick Skin Phototype.
    J Drugs Dermatol 2018 Feb;17(2):160-167
    Background: Acne vulgaris (acne) is prevalent in individuals with skin of color, often with more frequent sequelae than in patients with lighter skin color. It is important to determine if there are also differences in response to medications.

    Objective: This study evaluated the efficacy and tolerability of once-daily dapsone gel, 7. Read More

    Clinical evidence for washing and cleansers in acne vulgaris: a systematic review.
    J Dermatolog Treat 2018 Feb 25:1-6. Epub 2018 Feb 25.
    a The Ronald O. Perelman Department of Dermatology , NYU School of Medicine , New York , NY , USA.
    Purpose: Washing and over-the-counter cleansers are common interventions in acne vulgaris (AV), but the clinical evidence for their benefit is poorly understood. This systematic review presents clinical studies of washing and cleanser efficacy in acne vulgaris to guide treatment recommendations of dermatologists.

    Materials And Methods: We surveyed English-language articles indexed in MEDLINE (1951-March 2017) and EMBASE (1974-March 2017). Read More

    Vitamin D levels in acne vulgaris patients treated with oral isotretinoin.
    J Cosmet Dermatol 2018 Feb 20. Epub 2018 Feb 20.
    Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qina, Egypt.
    Background/objectives: Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. Read More

    Primary sebocytes and sebaceous gland cell lines for studying sebaceous lipogenesis and sebaceous gland diseases.
    Exp Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodore Fontane, Dessau, Germany.
    Sebocytes, the major cell type in sebaceous glands, are differentiated epithelial cells that gradually accumulate lipids and eventually disrupt, releasing their content (sebum) in a secretory process known as holocrine secretion. Via the hair canal, sebum reaches the skin surface, where it has several known or postulated functions, including pheromonal, thermoregulatory, antimicrobial and antioxidant activities. Altered sebum secretion and/or structural sebaceous gland changes have also been involved in the pathogenesis of skin diseases, such as acne vulgaris and some forms of alopecia. Read More

    Pyoderma gangrenosum, acne, and suppurative hidradenitis syndrome in end-stage renal disease successfully treated with adalimumab.
    Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.
    Division of Dermatology, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa.
    PASH syndrome (pyoderma gangrenosum, acne, and suppurative hidradenitis) forms part of the spectrum of autoinflammatory diseases. We report an unusual case of PASH syndrome in a patient with end-stagerenal disease (ESRD) who was successfully treated with the tumor necrosis factor inhibitor, adalimumab. The case underscores the challenges associatedwith the treatment of PASH syndrome as well as the ongoing search to establish a genetic basis for the syndrome. Read More

    Metformin as an adjunct therapy for the treatment of moderate to severe acne vulgaris.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    Lincoln Memorial University-DeBusk College of Osteopathic Medicine.
    The purpose of this literature review is to evaluate the use of metformin as an adjunct therapy in the treatment of moderate-to-severe acne in those not diagnosed with polycystic ovary syndrome (PCOS) or androgen excess. The authors conducted independent literature searches. Results were limited to clinical trials and randomized controlled trials. Read More

    The efficacy and safety of non-pharmacological therapies for the treatment of acne vulgaris: A systematic review and best-evidence synthesis.
    J Eur Acad Dermatol Venereol 2018 Feb 14. Epub 2018 Feb 14.
    Department of Dermatology, Radboud University Medical Center, Nijmegen, The Netherlands.
    Background: Acne vulgaris is a multifaceted skin disorder, affecting more than 85% of young individuals worldwide. Pharmacological therapy is not always desirable because of the development of antibiotic resistance or the potential risk of adverse effects. Non-pharmacological therapies can be viable alternatives for conventional therapies. Read More

    Formulation And In-Vitro And Ex-Vivo Evaluation Of Tretinoin Loaded Cubosomal Gel For Acne Treatment.
    Recent Pat Drug Deliv Formul 2018 02 13. Epub 2018 Feb 13.
    Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
    Objective: The current work was attempted to formulate and evaluate the topical sustained release delivery systems called cubosomes containing Tretinoin for the acne treatment. The recent patents on various formulations of tretinoin (EP0408370A2) helped in selecting a new formulation and evaluation.

    Methods: Tretinoin loaded cubosomes were prepared by bottom-up technique, using varying the concentration of lipid and surfactant and keeping the drug concentration constant, a total of nine formulations of tretinoin was developed. Read More

    A Qualitative Investigation of the Impact of Acne on Health-Related Quality of Life (HRQL): Development of a Conceptual Model.
    Dermatol Ther (Heidelb) 2018 Mar 12;8(1):85-99. Epub 2018 Feb 12.
    Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
    Introduction: The negative impact of acne on aspects of health-related quality of life (HRQL) has been demonstrated in many quantitative studies; however, there has been relatively little qualitative research exploring the impact of acne and the use of topical treatment. The study aimed to explore the impact of moderate-severe acne on HRQL in adolescents and adults with inflammatory and non-inflammatory lesions and to develop a conceptual model to illustrate the impact. In addition, the study aimed to identify the attributes of topical acne treatments that are most important for patients. Read More

    Comparing the Efficacy of Low Dose and Conventional Dose of Oral Isotretinoin in Treatment of Moderate and Severe Acne Vulgaris.
    J Res Pharm Pract 2017 Oct-Dec;6(4):233-238
    Department of Epidemiology and Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: This study was conducted to compare the effect of low-dose isotretinoin with its conventional dose in patients with moderate and severe acne.

    Methods: This was a clinical trial conducted on 60 male and female patients with moderate and severe acne vulgaris. The patients were divided into two treatment groups: 0. Read More

    Efficacy of Intense-pulsed Light Therapy with Topical Benzoyl Peroxide 5% versus Benzoyl Peroxide 5% Alone in Mild-to-moderate Acne Vulgaris: A Randomized Controlled Trial.
    J Res Pharm Pract 2017 Oct-Dec;6(4):199-205
    Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
    Objective: Acne vulgaris is a disease of pilosebaceous unit with multifactorial pathogenesis and threats patients' social functioning. There is a growing research to find faster, more effective, and easy to use treatments. The aim of this study is to evaluate the efficacy of benzoyl peroxide 5% (BP) with and without concomitant intense-pulsed light (IPL) therapy in mild-to-moderate acne vulgaris. Read More

    Topical 5-aminolevulinic photodynamic therapy with red light vs intense pulsed light for the treatment of acne vulgaris: A spilit face, randomized, prospective study.
    Dermatoendocrinol 2017 13;9(1):e1375634. Epub 2017 Oct 13.
    Shanghai Skin Disease Hospital, Institute of Photomedicine, Tongji University School of Medicine, Shanghai, China.
    5-Aminolevulinic acid photodynamic therapy (ALA-PDT) has been an effective method for treating acne vulgaris. Red light is the most widely used light source while Intense pulsed lights (IPL) is reported effective and well-tolerated. The purpose of this study was to evaluate the efficacy and adverse reactions of ALA-PDT with red light on acne compared with ALA-PDT with IPL. Read More

    Propionibacterium acnes-Derived Extracellular Vesicles Promote Acne-Like Phenotypes in Human Epidermis.
    J Invest Dermatol 2018 Jan 31. Epub 2018 Jan 31.
    Basic Research & Innovation Division, R&D Unit, AmorePacific Corporation, Yongin, Republic of Korea. Electronic address:
    Acne vulgaris is an inflammatory disease occurring in the pilosebaceous unit and is the most common skin condition in young people. A gram-positive bacterium, Propionibacterium acnes, has been suspected to contribute to the development of acne. Here, we report that P. Read More

    A Time-Series Study of the Effect of Air Pollution on Outpatient Visits for Acne Vulgaris in Beijing.
    Skin Pharmacol Physiol 2018 7;31(2):107-113. Epub 2018 Feb 7.
    Department of Dermatology, The General Hospital of Air Force, Beijing, China.
    Background/aims: There is increasing evidence that exposure to air pollutants, including particulate matter (PM2.5, PM10), nitrogen dioxide (NO2), and sulfur dioxide (SO2), might aggravate preexisting skin diseases such as eczema and urticaria. Here we investigated if a possible link exists between air pollution and acne vulgaris. Read More

    Plasma exeresis for active acne vulgaris: Clinical and in vivo microscopic documentation of treatment efficacy by means of reflectance confocal microscopy.
    Skin Res Technol 2018 Feb 6. Epub 2018 Feb 6.
    Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

    Different Toxicity of Cetuximab and Panitumumab in Metastatic Colorectal Cancer Treatment: A Systematic Review and Meta-Analysis.
    Oncology 2018 23;94(4):191-199. Epub 2018 Jan 23.
    Oncology Unit, Oncology Department, ASST Ospedale di Cremona, Cremona, Italy.
    Background: Over the last few years only one large randomized phase III study has tried to prospectively assess the safety of cetuximab and panitumumab in a head-to-head comparison. Despite the similar overall toxicity profile, cetuximab and panitumumab retain peculiar safety characteristics that deserve to be deeply investigated.

    Methods: We conducted a systematic review for randomized trials in PubMed, the Cochrane Central Register of Controlled Trials, SCOPUS, Web of Science, and EMBASE using the terms ("cetuximab" or "panitumumab") AND ("colorectal cancer" OR "colorectal carcinoma"). Read More

    Efficacy of photodynamic therapy combined with minocycline for treatment of moderate to severe facial acne vulgaris and influence on quality of life.
    Medicine (Baltimore) 2017 Dec;96(51):e9366
    Department of Dermatology.
    Background: Acne vulgaris is a prevalent skin disorder impairing both physical and psychosocial health. This study was designed to investigate the effectiveness of photodynamic therapy (PDT) combined with minocycline in moderate to severe facial acne and influence on quality of life (QOL).

    Methods: Ninety-five patients with moderate to severe facial acne (Investigator Global Assessment [IGA] score 3-4) were randomly treated with PDT and minocycline (n = 48) or minocycline alone (n = 47). Read More

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