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Dermatol Ther 2022 Jun 15:e15637. Epub 2022 Jun 15.

Department of Dermatology, Hospital Universitario 12 de Octubre, I+12 Research Institute, Universidad Complutense, Madrid, Spain.

Case Rep Dermatol 2022 May-Aug;14(2):112-116. Epub 2022 May 9.

Section of Dermatology, Department of Health Sciences, University of Genoa, IRCCS, Genoa, Italy.

Acne fulminans (AF) is a rare and severe form of inflammatory acne that typically occurs in male adolescents with acne vulgaris and is characterized by the sudden onset of painful, bleeding, and ulcerated lesions. It has been described very rarely in association with hidradenitis suppurativa (HS). Its onset may be induced by drugs, particularly isotretinoin. Read More

Pediatr Dermatol 2022 May 18. Epub 2022 May 18.

Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital San Diego, San Diego, California, USA.

Background: Acne vulgaris varies in clinical severity, from minimal comedonal disease to severe hemorrhagic and ulcerative lesions with scarring. While a family history confers a higher risk for developing acne, the correlation between heritability and clinical severity remains unclear.

Objective: To examine the natural history and heritability of severe acne with scarring in patients undergoing isotretinoin therapy. Read More

J Eur Acad Dermatol Venereol 2022 Apr 24. Epub 2022 Apr 24.

Department of Dermatology and Allergy, Ludwig-Maximilian-University of Munich, Munich, Germany.

In the late 1960s, palmoplantar pustulosis (PPP) with sternocostoclavicular arthropathy was first described in Japan, predominantly affecting women in the perimenopausal age. In the 1970s, the chronic non-bacterial osteomyelitis and chronic recurrent multifocal osteomyelitis were initially observed in paediatric patients with approximately 70% girls. Acne fulminans accompanied by polyarthralgia have been observed since early 1970s, which almost exclusively occurs in adolescent boys. Read More

JAAD Case Rep 2022 Mar 6;21:32-34. Epub 2022 Jan 6.

Department of Dermatology, University of Rochester Medical Center, Rochester, New York.

Photodermatol Photoimmunol Photomed 2021 Dec 17. Epub 2021 Dec 17.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Napoli, Italy.

J Cutan Med Surg 2021 Sep 9:12034754211045379. Epub 2021 Sep 9.

536164 Ankara Bilkent City Hospital, Turkey.

Cutis 2021 Jul;108(1):51-54

Mr. Ranpariya is from Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey. Dr. Baldwin is from Acne Treatment and Research Center, Morristown, New Jersey.

Rosacea fulminans (RF) is a rare facial dermatosis that typically affects women with a fulminating course that presents with superficial and deep-seated papules, pustules, and nodules, as well as an intense reddish or cyanotic erythema localized to the face. Although the etiology of RF remains unknown, immunologic, hormonal, and vascular factors have been implicated. We describe a case of a 32-year-old pregnant woman presenting with RF. Read More

Skin Appendage Disord 2021 Jun 30;7(4):329-332. Epub 2021 Mar 30.

National and Kapodistrian University of Athens, Faculty of Medicine, 1st department of Dermatology-Venereology, Andreas Sygros Hospital, Athens, Greece.

The coexistence of hidradenitis suppurativa (HS) and acne fulminans (AF) has only recently been reported in the literature. We present a case of a 17-year-old man who presented with a 2 years history of severe acne and HS. He was initially started on oral clindamycin and rifampicin for 3 months with no clinical improvement. Read More

Skin Appendage Disord 2021 Feb 21;7(2):115-119. Epub 2021 Jan 21.

Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.

Acne fulminans (AF) is a rare, acute, and severe form of acne vulgaris often associated with systemic symptoms. Its treatment is challenging and controversial. We report a case of isotretinoin-induced AF (IIAF) in a 12-year-old boy resistant to traditional therapies (oral steroids and isotretinoin). Read More

J Cosmet Dermatol 2021 Jul 22;20(7):2036-2039. Epub 2021 Feb 22.

Dermatological Surgery & Laser Unit, St John's Institute of Dermatology, Guy's Hospital Cancer Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Background: Sixty years ago, Ross discussed the use of oral dapsone in the treatment of acne vulgaris. Ross was fundamental in demonstrating the importance of this medication in dermatology. Following this, topical formulations have been used for the treatment of acne vulgaris which has not responded to traditional therapies. Read More

Dermatol Online J 2020 Dec 15;26(12). Epub 2020 Dec 15.

Department of Dermatology, Université Libre de Bruxelles, Queen Fabiola University Hospital for Children, Brussels.

Acne fulminans is a rare complication of classic acne. Less than 200 cases have been reported. It usually affects adolescent males with pre-existing acne vulgaris. Read More

J Dermatol 2021 Feb 22;48(2):e120-e121. Epub 2020 Nov 22.

Department of Dermatology, Graduate school of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.

Ital J Pediatr 2020 Nov 13;46(1):169. Epub 2020 Nov 13.

Department of Health Science, University of Florence, Florence, Italy.

Background: SAPHO (synovitis, acne, pustolosis, hyperostosis and osteitis) syndrome is a rare autoinflammatory chronic disorder, presenting with non-infectious osteitis, sterile joint inflammation and skin manifestations including palmoplantar pustolosis and severe acne. It could be often misdiagnosed for its heterogeneous clinical presentation. Treatment is challenging and, due to the rarity of this syndrome, no randomized controlled clinical trials have been conducted. Read More

G Ital Dermatol Venereol 2020 Dec 21;155(6):711-718. Epub 2020 Oct 21.

Dermatology Clinic, University of Catania, Catania, Italy -

Acne fulminans (AF) is a rare and severe form of inflammatory acne presenting clinically with an abrupt outburst of painful, hemorrhagic pustules and ulceration, that may or may not be associated with systemic symptoms, such as fever, polyarthritis, and laboratory abnormalities. It typically affects male teenagers with a pre-existing acne. Although the pathogenetic mechanism has not been established yet, a role of genetic, abnormal immunologic response, drugs intake, hormonal imbalance and viral infection, as causal factors, has been identified. Read More

Dis Mon 2021 Apr 9;67(4):101103. Epub 2020 Oct 9.

Department of Pediatric and Adolescent Medicine, Western Michigan University, Homer Stryker M.D. School of Medicine, 1000 Oakland Drive, Kalamazoo, MI 49008-1284, United States.

Acne vulgaris is a chronic, inflammatory, skin condition that involves the pilosebaceous follicles and is influenced by a variety of factors including genetics, androgen-stimulation of sebaceous glands with abnormal keratinization, colonization with Cutibacterium acnes (previously called Propionibacterium acnes), and pathological immune response to inflammation. Acne can occur at all ages and this discussion focuses on the first three decades of life. Conditions that are part of the differential diagnosis and/or are co-morbid with acne vulgaris are also considered. Read More

Pediatr Dermatol 2020 Nov 1;37(6):1169-1170. Epub 2020 Oct 1.

Department of Dermatovenereology, Rare Disease Center, West China Hospital, Sichuan University, Chengdu, China.

Acne fulminans is a severe form of acne vulgaris accompanied by systemic symptoms. A 17-year-old Chinese boy presented with an outbreak of necrotic lesions on his face eight days after the onset of palpable purpura, arthralgia, fever, abdominal pain, and proteinuria. He was successfully treated with oral prednisolone and isotretinoin. Read More

Dermatol Online J 2020 Aug 15;26(8). Epub 2020 Aug 15.

McGovern Medical School at University of Texas Health Houston, Houston, TX.

Multiple prescription medications may cause or aggravate acne. A number of dietary supplements have also been linked to acne, including those containing vitamins B6/B12, iodine, and whey, as well as "muscle building supplements" that may be contaminated with anabolic-androgenic steroids (AAS). Acne linked to dietary supplements generally resolves following supplement discontinuation. Read More

Dermatology 2021 16;237(5):827-834. Epub 2020 Sep 16.

Dermatology Clinic, Strasbourg University and Strasbourg University Hospitals, Strasbourg, France.

Background: Acne is a common condition. Sometimes acne or acne-like features are a part of autoinflammatory diseases such as PAPA spectrum disorders. Our objective wasto determine whether acne in PAPA spectrum disorders has specific phenotypic traits. Read More

J Rheumatol 2020 12 1;47(12):1793-1799. Epub 2020 Apr 1.

A. Faye, MD, PhD, Department of General Pediatrics, Pediatric Infectious Diseases and Pediatric Rheumatology, Hôpital Robert Debré, AP-HP, National Reference Centre for Rare Pediatric Inflammatory Rheumatisms and Systemic Auto-immune diseases (RAISE), and Biology and Genetics of Bacterial Cell Wall Unit, Institut Pasteur, Paris.

Objective: Acne fulminans (AF) is a rare, explosive systemic form of acne. Chronic nonbacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO) is a primarily pediatric autoinflammatory disorder characterized by sterile osteolytic bone lesions. Concomitant occurrence of CNO/CRMO and AF is very rare, and little is known about the epidemiological and clinical particularities of this association. Read More

Photodiagnosis Photodyn Ther 2020 Mar 20;29:101630. Epub 2019 Dec 20.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:

In this work, we present a case of deteriorative acne that occurred during methylprednisolone and danazol treatment of idiopathic thrombocytopenic purpura (ITP). Treatment of the patient with a combination of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) and isotretinoin was satisfactory, though the patient had platelets as low as 4-10 × 10/L during treatment. We consider that the combination of oral isotretinoin and ALA-PDT was effective in this patient may be due to the synergetic effect of these treatments. Read More

J Eur Acad Dermatol Venereol 2020 Apr 16;34(4):827-833. Epub 2020 Jan 16.

Department of Dermatology, CHU Nantes, Nantes, France.

Background: Acne fulminans (AF) is a rare and severe form of inflammatory acne. It is characterized by a sudden worsening of acne with appearance of ulceronecrotic lesions, which can be associated with systemic signs. Its pathophysiology and the best therapeutic strategy are only partially known. Read More

Acta Derm Venereol 2020 Jan 23;100(1):adv00036. Epub 2020 Jan 23.

Department of Dermatology and Venerology, University Hospital of Brest, FR-29200 Brest, France.

Cutis 2019 Jun;103(6):E20-E21

Department of Dermatology, Venereology, and Allergology, Medical University of Gdańsk, Poland.

Indian J Dermatol Venereol Leprol 2020 Nov-Dec;86(6):669-673

One Center for Rheumatology and Genetics, Trivia Complex, Natubhai Circle, Vadodara, Gujarat, India.

A 19-year-old man with granulomatosis with polyangiitis (Wegener's disease) presented with hemorrhagic facial nodules mimicking severe inflammatory acne (acne fulminans) as one of the first symptoms of the disease. The lesions were earlier treated as nodulocystic acne with isotretinoin without any benefit. Complete resolution was seen with pulsed methylprednisolone and oral prednisolone and mycophenolate mofetil thereafter. Read More

Eur J Dermatol 2019 Aug;29(4):438-439

Dermatology Department, Amiri Hospital-Ministry of health, Kuwait Omariya-, P.O box:49185, 85152 Kuwait.

JAAD Case Rep 2019 Jun 8;5(6):525-528. Epub 2019 Jun 8.

Institut Pasteur, Centre Médical de l'Institut Pasteur, Paris, France.

J Dtsch Dermatol Ges 2019 08 6;17(8):837-838. Epub 2019 May 6.

Department of Dermatology, University Hospital of Jena, Jena, Germany.