14,267 results match your criteria Acne Vulgaris

Adverse Events in Isotretinoin Therapy: A Single-Arm Meta-Analysis.

Int J Environ Res Public Health 2022 May 26;19(11). Epub 2022 May 26.

Department of Dermatology Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.

Isotretinoin (ISO) is an oral prescription-only retinoid, well known for its acne-treating effect. However, it affects a substantial number of human cell types, causing a broad spectrum of adverse effects. The purpose of this study is to establish the isotretinoin therapy adverse events among human clinical trials and their prevalence. Read More

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Development of a topical bacteriophage gel targeting for acne prone skin and results of a phase 1 cosmetic randomized clinical trial.

Skin Health Dis 2022 Jun 28;2(2):e93. Epub 2022 Jan 28.

BiomX Ltd Ness Ziona Israel.

Background: Topical antibiotics are frequently used to treat acne vulgaris. Their prolonged use, often for longer durations than recommended, has led to antibiotic resistance in , a bacterium implicated in acne pathophysiology. Bacteriophage (phage), which specifically target by a different mechanism of action and do not harm potentially beneficial bacteria, may offer an alternative approach for improvement of the appearance of acne prone skin. Read More

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Acne Vulgaris and Metabolic Syndrome: A Possible Association.

Cureus 2022 May 5;14(5):e24750. Epub 2022 May 5.

Radiology, Dr. D. Y. Patil Medical College, Research Centre and Hospital, Pune, IND.

Introduction Acne vulgaris is an androgen-dependent disorder with excessive sebum production and proliferation of Metabolic syndrome (MetS) is a multisystem disorder that increases the risk of diabetes mellitus, stroke, and cardiovascular diseases. ​This study aims to analyze the association of MetS with acne vulgaris. Methods A cross-sectional study was conducted with 65 cases of acne vulgaris and 65 age and sex-matched controls. Read More

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The Many Faces of Pediatric Acne: How to Tailor Nonprescription Acne Treatment and Skincare Using Cleansers and Moisturizers.

J Drugs Dermatol 2022 Jun;21(6):602-612

Background: Acne vulgaris (acne) is a common, complex, multifactorial disorder. Various expressions of acne in childhood can be categorized by age, severity, and pubertal status.

Objective: To improve pediatric acne patients’ outcomes, various expressions of pediatric acne to educate and tailor nonprescription acne treatment and skincare using cleansers and moisturizers were defined and discussed. Read More

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Hormonal Therapies in the Management of Acne Vulgaris.

J Drugs Dermatol 2022 Jun;21(6):618-623

Acne vulgaris is a multifactorial chronic disorder of the pilosebaceous unit. Established treatments include topical retinoids, antibiotics in mild cases, and oral antibiotics and isotretinoin in moderate to severe cases. Anti-androgens and other hormonal therapies constitute another group of drugs in the armamentarium of acne management. Read More

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Never Give Up! Continued Progress in Development of Topical Therapies for Acne Is a Good Thing.

James Del Rosso

J Drugs Dermatol 2022 Jun;21(6):571-572

In July 2022, I will reach the milestone of practicing dermatology for 36 years, with 30 years of experience also devoted to clinical research. My background in pharmacy before attending medical school set the stage for my strong interest in therapeutics with regular participation in educational initiatives at many meetings and in multiple peer-reviewed publications addressing several therapeutic areas. Ultimately, my primary interest is to translate important advances in our understanding of common chronic skin diseases and/or their management to dermatology clinicians who practice day-to-day in the trenches. Read More

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Advances in Topical Management of Adolescent Facial and Truncal Acne: A Phase 3 Pooled Analysis of Safety and Efficacy of Trifarotene 0.005% Cream.

J Drugs Dermatol 2022 Jun;21(6):582-586

Purpose: Acne vulgaris is very common among adolescents and young adults. It is important for clinicians who provide care to these patients to have a plan of action for assessing and managing acne in daily practice.

Methods: Post-hoc analysis of two large-scale phase 3 pivotal trials of trifarotene 0. Read More

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Oral Vitamin A for Acne Management: A Possible Substitute for Isotretinoin.

J Drugs Dermatol 2022 Jun;21(6):683-686

Background: Recent changes to the iPLEDGE platform left providers without the ability to prescribe isotretinoin to their patients. A potential substitute for isotretinoin could be beneficial when the drug is unavailable. Prior to the FDA approval of isotretinoin, a vitamin A derivative, vitamin A was studied for its use in acne management. Read More

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Tazarotene 0.045% Lotion for Females With Acne: Analysis of Two Adult Age Groups.

J Drugs Dermatol 2022 Jun;21(6):587-595

Background: Females aged ≥25 years may have acne with different etiology, presentation, burden, and treatment response than females 18–24 years. This post hoc analysis investigated efficacy and safety of tazarotene 0.045% lotion in females ≥18 years or ≥25 years of age. Read More

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A Prospective, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy, Safety, and Patient Satisfaction of Tretinoin 0.05% Lotion for Chest Rejuvenation.

J Drugs Dermatol 2022 Jun;21(6):645-652

Background: There is increasing interest in non-invasive options for chest rejuvenation with minimal to no downtime. Topical retinoids have long been used to correct photoaging due to their ability to promote epidermal hyperplasia, matrix metalloproteinase inhibition, collagen synthesis, and dispersion of melanin granules. Topical retinoid use is often limited by the ensuing irritation that occurs with initial use and resolves after about one month. Read More

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Imaging Manifestation of Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis Syndrome.

Sultan Qaboos Univ Med J 2022 May 26;22(2):306-308. Epub 2022 May 26.

Department of Radiology and Molecular Imaging, Sultan Qaboos University Hospital, Muscat, Oman.

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Retinoic acid inhibits the angiogenesis of human embryonic stem cell-derived endothelial cells by activating FBP1-mediated gluconeogenesis.

Stem Cell Res Ther 2022 Jun 7;13(1):239. Epub 2022 Jun 7.

Department of Cardiovascular Surgery of the First Affiliated Hospital & Institute for Cardiovascular Science, Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Suzhou Medical College, Soochow University, Suzhou, 215000, China.

Background: Endothelial cells are located in the inner lumen of blood and lymphatic vessels and exhibit the capacity to form new vessel branches from existing vessels through a process called angiogenesis. This process is energy intensive and tightly regulated. Glycolysis is the main energy source for angiogenesis. Read More

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Trifarotene: A Novel Therapeutic Option for Acne.

Piyu Parth Naik

Dermatol Res Pract 2022 27;2022:1504303. Epub 2022 May 27.

Department of dermatology, Saudi German hospital and clinic, Burj Al Arab, Dubai, UAE.

Acne vulgaris, or acne, is a prevailing cutaneous predicament that customarily crops up on the face, neck, and trunk in the forms of comedones, papules, pustules, and nodules. According to epidemiologic explorations, acne affects 9.4% of the global population, making it the eighth most common disease globally. Read More

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Evaluating resurfacing modalities in aesthetics.

Clin Dermatol 2022 May-Jun;40(3):274-282. Epub 2021 Feb 2.

Department of Dermatology, Alpert Medical School, Brown University, Providence, Rhode Island, USA; GK Dermatology, PC, South Weymouth, Massachusetts, USA; Department of Dermatology, Medical School of Jundiaí, São Paulo, Brazil. Electronic address:

Skin resurfacing for cutaneous rejuvenation has evolved with the development of a plethora of nonsurgical and minimally invasive modalities. We have highlighted the advances in laser therapy, chemical peels, radiofrequency, microneedling, and platelet-rich plasma therapy. We have also included studies providing head-to-head comparisons between procedures and discussed relevant debates in the field. Read More

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The influence of cosmetics dedicated to oily and acne-prone skin on skin parameters.

J Cosmet Dermatol 2022 Jun 6. Epub 2022 Jun 6.

Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Katowice, Poland.

Introduction: Patient compliance with care recommendations is closely related to the role of cosmetics in delaying or preventing the side effects of medications used to treat acne.

Methods: A total of 33 volunteers with symptoms of acne vulgaris were qualified for the study. The skin parameters were measured before the experiment, after the 4 and at the 8 weeks of use. Read More

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Patients' Awareness of the Ocular Side Effects of Isotretinoin Therapy: A Study From Saudi Arabia.

Cureus 2022 Apr 30;14(4):e24628. Epub 2022 Apr 30.

Dermatology, King Abdulaziz University Hospital, Jeddah, SAU.

Introduction Isotretinoin is one of the most commonly prescribed drugs among dermatologists because it's used in the treatment of Acne vulgaris. Despite having an adequate safety profile, isotretinoin-related adverse events are common, with ocular manifestations being one of them. Although being generally mild, ophthalmologic manifestations associated with isotretinoin may cause significant ocular morbidity. Read More

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Oral Isotretinoin for Acne in the US Military: How Accelerated Courses and Teledermatology Can Minimize the Duty-Limiting Impacts of Treatment.

Cutis 2022 Feb;109(2):75-78

Naval Medical Readiness and Training Command San Diego, California.

Acne vulgaris is a common dermatologic disease affecting 40 to 50 million individuals in the United States each year. It has a peak incidence in adolescents and young adults; however, for some patients, the disease may persist well into adulthood. These incidence peaks coincide with the age demographic of a large proportion of military service members. Read More

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February 2022

Removal of Isotretinoin Gender-Based Guidelines: Inclusivity Takes Precedence.

Sonali Nanda

Cutis 2022 Mar;109(3):E18-E20

University of Oklahoma, Oklahoma City.

The iPLEDGE Risk Evaluation and Mitigation Strategy (REMS) system recently underwent major structural changes. After many years of advocacy by physicians and patients, the program has changed to reflect more inclusivity in the enrollment process. Specifically, the risk categories of females of reproductive potential, females not of reproductive potential, and males were replaced by 2 categories: (1) people who can get pregnant, and (2) people who cannot get pregnant. Read More

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Investigation of systemic immune-inflammation index and systemic inflammation response index as an indicator of the anti-inflammatuary effect of isotretinoin in patients with acne vulgaris.

Cutan Ocul Toxicol 2022 Jun 5;41(2):174-178. Epub 2022 Jun 5.

Education and Research Hospital, Sakarya University, Sakarya, Turkey.

Purpose: Oral isotretinoin (ISO) can effect markers of inflammation in patients with acne vulgaris. Systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) were described as novel inflammatory and prognostic biomarkers. The present study aimed to evaluate the effectiveness of SII, SIRI, and other inflammatory markers in patients with acne vulgaris who receive isotretinoin therapy. Read More

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Correlation between Serum 25-Hydroxy Vitamin D Levels and the Severity of Acne Vulgaris: A Systematic Review.

Indian J Dermatol 2022 Jan-Feb;67(1):31-36

Department of Public Health and Preventive Medicine, Faculty of Medicine, Airlangga University, Kota SBY, Jawa Timur, Indonesia.

Background: Vitamin D is thought to play a role in the pathogenesis of acne, and its levels can change in patients with acne vulgaris. Several studies have revealed that serum 25-hydroxy vitamin D levels tend to be low and statistically significant in acne vulgaris patients. However, the relationship between vitamin D levels and acne severity is still poorly understood. Read More

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Insulin resistance in the course of acne - literature review.

Postepy Dermatol Alergol 2022 Apr 18;39(2):231-238. Epub 2021 Jun 18.

Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, Poznan, Poland.

is a very common skin disease being diagnosed in Westernized populations, however, its multifactorial etiopathogenesis still remains unclear. Recent research has demonstrated a possible linkage between acne and insulin resistance (IR), which is the topic of our review. In addition to an inappropriate diet, excessive androgen production or obesity, it is the IR which might be responsible for lack of efficacy of classical treatment strategy in acne. Read More

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Upadacitinib as induction and maintenance therapy for moderately to severely active ulcerative colitis: results from three phase 3, multicentre, double-blind, randomised trials.

Lancet 2022 06 26;399(10341):2113-2128. Epub 2022 May 26.

Inflammatory Bowel Disease Unit, Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB, Canada.

Background: There is a great unmet need for advanced therapies that provide rapid, robust, and sustained disease control for patients with ulcerative colitis. We assessed the efficacy and safety of upadacitinib, an oral selective Janus kinase 1 inhibitor, as induction and maintenance therapy in patients with moderately to severely active ulcerative colitis.

Methods: This phase 3, multicentre, randomised, double-blind, placebo-controlled clinical programme consisted of two replicate induction studies (U-ACHIEVE induction [UC1] and U-ACCOMPLISH [UC2]) and a single maintenance study (U-ACHIEVE maintenance [UC3]). Read More

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Trends in Office Visits for the Five Most Common Skin Diseases in the United States.

J Clin Aesthet Dermatol 2022 May;15(5):E82-E86

Ms. Peck is with the College of Medicine at the University of Cincinnati in Cincinnati, Ohio.

Objective: We sought to determine the outpatient visit rates for the five most common skin conditions among dermatologists and non-dermatologists.

Methods: We conducted a population-based, cross-sectional analysis using the National Ambulatory Medical Care Survey between 2007 and 2016, the most recent years available.

Results: The five most common skin diagnoses among all medical specialties were contact dermatitis, acne vulgaris, actinic keratosis, benign neoplasm of the skin, and epidermoid cyst, respectively. Read More

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KIEGLFN: A unified acne grading framework on face images.

Comput Methods Programs Biomed 2022 Jun 25;221:106911. Epub 2022 May 25.

Harbin Institute of Technology, Harbin, 150001, Heilongjiang China. Electronic address:

Background And Objective: Grading the severity level is an extremely important procedure for correct diagnoses and personalized treatment schemes for acne. However, the acne grading criteria are not unified in the medical field. This work aims to develop an acne diagnosis system that can be generalized to various criteria. Read More

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Mites in Relation to the Degree of among Egyptian Patients.

Pak J Biol Sci 2022 Jan;25(5):406-414

<b>Background and Objective:</b> <i>Demodex</i> mites are considered to play a pathogenic role in facial dermatoses as <i>Acne vulgaris</i>. In this study the association between <i>Acne vulgaris</i> and <i>Demodex</i> spp. intensity, kind and activity were investigated. Read More

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January 2022

Classification of clinical Cutibacterium acnes isolates at phylotype level by capillary electrophoretic methods in roughened fused silica capillary.

Talanta 2022 Sep 18;247:123565. Epub 2022 May 18.

Department of Fluid Phase Separations, Institute of Analytical Chemistry of the CAS, Veveří 97, 602 00, Brno, Czech Republic.

Despite being commensal bacterium involved in the maintenance of healthy skin, Cutibacterium acnes is also associated with inflammatory diseases. Since inflammatory and immunogenic properties vary between C. acnes phylotypes, reliable classification of clinical C. Read More

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September 2022

Phytopigment Alizarin Inhibits Multispecies Biofilm Development by , , and .

Pharmaceutics 2022 May 12;14(5). Epub 2022 May 12.

School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Korea.

Acne vulgaris is a common chronic inflammatory skin disease involving with other skin commensals such as and in the anaerobic and lipid-rich conditions of pilosebaceous units. These microbes readily form multispecies biofilms that are tolerant of traditional antibiotics as well as host immune systems. The phytopigment alizarin was previously found to prevent biofilm formation by and strains under aerobic conditions. Read More

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Ischemia-Modified Albumin-A Potential New Marker of Oxidative Stress in Dermatological Diseases.

Medicina (Kaunas) 2022 May 17;58(5). Epub 2022 May 17.

Department of Dermatology, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania.

There is growing evidence that oxidative stress is involved in the pathogenesis of numerous conditions, including dermatological diseases. Various markers are available to assess oxidative stress, but none of these can be considered the ideal marker. Recent studies have shown that ischemia-modified albumin (IMA) is not only an indicator of ischemia, but also a marker of oxidative stress. Read More

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Methods for the Improvement of Acne Scars Used in Dermatology and Cosmetology: A Review.

J Clin Med 2022 May 12;11(10). Epub 2022 May 12.

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, 50-368 Wrocław, Poland.

Acne vulgaris is a chronic skin disease that, depending on its course, is characterized by the occurrence of various skin eruptions such as open and closed comedones, pustules, papules, and cysts. Incorrectly selected treatment or the presence of severe acne vulgaris can lead to the formation of atrophic scars. In this review, we summarize current knowledge on acne scars and methods for their improvement. Read More

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