5,379 results match your criteria Acm Transactions On Software Engineering And Methodology[Journal]

Toward Multimodal Modeling of Emotional Expressiveness.

Proc ACM Int Conf Multimodal Interact 2020 Oct;2020:548-557

Carnegie Mellon University.

Emotional expressiveness captures the extent to which a person tends to outwardly display their emotions through behavior. Due to the close relationship between emotional expressiveness and behavioral health, as well as the crucial role that it plays in social interaction, the ability to automatically predict emotional expressiveness stands to spur advances in science, medicine, and industry. In this paper, we explore three related research questions. Read More

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October 2020

Enhanced Segmentation of Inflamed ROI to Improve the Accuracy of Identifying Benign and Malignant Cases in Breast Thermogram.

J Oncol 2021 21;2021:5566853. Epub 2021 Apr 21.

Radiation Oncology, Harshamitra Super Speciality Cancer Centre and Research Institute, Trichy, India.

Effective analysis of breast thermography needs an accurate segmentation of the inflamed region in Infrared Breast Thermal Images (IBTI) which helps in the diagnosis of breast cancer. However, IBTI suffers from intensity inhomogeneity, overlapping regions of interest, poor contrast, and low signal-to-noise ratio (SNR) due to the imperfect image acquisition process. To mitigate this, this work proposes an enhanced segmentation of the inflamed Region of Interest (ROI) using an active contour method driven by the multiscale local and global fitted image (MLGFI) model. Read More

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Whether to transfer mosaic embryos: a cytogenetic view of true mosaicism by amniocentesis.

Reprod Biomed Online 2021 Mar 6. Epub 2021 Mar 6.

Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Research Question: Preimplantation genetic testing for aneuploidies has increasingly been employed for embryo selection, resulting in a recent surge in mosaic embryos. According to the cytogenetic results, which types of mosaic embryo survive early pregnancy, progress to the second trimester and finally result in a live birth?

Design: This study evaluated 30,587 pregnant women undergoing amniocentesis from January 2004 to March 2020 at the cytogenic centre of Kaohsiung Chang Gung Memorial Hospital. Samples from amniocentesis were cultured using the in-situ method. Read More

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Learning Prognostic Models using DiseaseProgression Patterns: Predicting the Need forNon-Invasive Ventilation in Amyotrophic LateralSclerosis.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 7;PP. Epub 2021 May 7.

Amyotrophic Lateral Sclerosis is a devastating neurodegenerative disease causing rapid degeneration of motor neurons and usually leading to death by respiratory failure. Since there is no cure, treatment's goal is to improve symptoms and prolong survival. Non-invasive Ventilation (NIV) is an effective treatment, leading to extended life expectancy and improved quality of life. Read More

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Computational modeling of gene-specific transcriptional repression, activation and chromatin interactions in leukemogenesis by LASSO-regularized logistic regression.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 7;PP. Epub 2021 May 7.

Many physiological and pathological pathways are dependent on gene-specific on/off regulation of transcription. Some genes are repressed, while others are activated. Although many previous studies have analyzed the mechanisms of gene-specific repression and activation, these studies are mainly based on the use of candidate genes, which are either repressed or activated, without simultaneously comparing and contrasting both groups of genes. Read More

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Netpro2vec: a Graph Embedding Framework for Biomedical Applications.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 7;PP. Epub 2021 May 7.

The ever-increasing importance of structured data in different applications, especially in the biomedical field, has driven the need for reducing its complexity through projections into a more manageable space. The latest methods for learning features on graphs focus mainly on the neighborhood of nodes and edges. Methods capable of providing a representation that looks beyond the single node neighborhood are kernel graphs. Read More

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Model for End-Stage Liver Disease Score Predicts the Mortality of Patients with Coronary Heart Disease Who Underwent Percutaneous Coronary Intervention.

Cardiol Res Pract 2021 17;2021:6401092. Epub 2021 Apr 17.

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Coronary heart disease (CHD) is caused by the blockage or spasm of coronary arteries. Evidence shows that liver disease is related to CHD. However, the correlation between the Model for End-Stage Liver Disease (MELD) score and outcomes in patients after percutaneous coronary intervention (PCI) was unclear. Read More

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Drug-target interaction prediction using multi-head self-attention and graph attention network.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 6;PP. Epub 2021 May 6.

Identifying drug-target interactions (DTIs) is an important step in the process of new drug discovery and drug repositioning. Accurate predictions for DTIs can improve efficiency in drug discovery and development. Although rapid advances in deep learning technologies have generated various computational methods, it is still appealing to further investigate how to design efficient networks for predicting DTIs. Read More

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Unsupervised manifold alignment for single-cell multi-omics data.

ACM BCB 2020 Sep;2020:1-10

Department of Genome Sciences, University of Washington, Paul G. Allen School of Computer Science and Engineering, University of Washington.

Integrating single-cell measurements that capture different properties of the genome is vital to extending our understanding of genome biology. This task is challenging due to the lack of a shared axis across datasets obtained from different types of single-cell experiments. For most such datasets, we lack corresponding information among the cells (samples) and the measurements (features). Read More

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September 2020

Echocardiography Predictors of Survival in Hypertensive Patients With Left Ventricular Hypertrophy.

Am J Hypertens 2021 May 5. Epub 2021 May 5.

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.

Background: Left ventricular hypertrophy (LVH) is a well-known target organ damage. Concentric hypertrophy is the strongest predictor of increased risk of cardiovascular events, but the predictive value of individual echocardiographic parameters remains unclear.The aim of this study was to search for echocardiographic and hemodynamic variables associated with concentric and eccentric remodeling and their association with long-term cardiovascular outcomes. Read More

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Artificial Intelligence Applications for COVID-19 in Intensive Care and Emergency Settings: A Systematic Review.

Int J Environ Res Public Health 2021 04 29;18(9). Epub 2021 Apr 29.

Duke-NUS Medical School, National University of Singapore, Singapore 169857, Singapore.

: Little is known about the role of artificial intelligence (AI) as a decisive technology in the clinical management of COVID-19 patients. We aimed to systematically review and critically appraise the current evidence on AI applications for COVID-19 in intensive care and emergency settings. : We systematically searched PubMed, Embase, Scopus, CINAHL, IEEE Xplore, and ACM Digital Library databases from inception to 1 October 2020, without language restrictions. Read More

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Fast Optimal Circular Clustering and Applications on Round Genomes.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 4;PP. Epub 2021 May 4.

Round genomes are found in bacteria, plant chloroplasts, and mitochondria. Genetic or epigenetic marks can present biologically interesting clusters along a circular genome. The circular data clustering problem groups N points on a circle into K clusters to minimize the within-cluster sum of squared distances. Read More

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Sorting Permutations by Intergenic Operations.

IEEE/ACM Trans Comput Biol Bioinform 2021 May 4;PP. Epub 2021 May 4.

Genome Rearrangements are events that affect large stretches of genomes during evolution. Many mathematical models have been used to estimate the evolutionary distance between two genomes based on genome rearrangements. However, most of them focused on the (order of the) genes of a genome, disregarding other important elements in it. Read More

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Supervised Prediction of Aging-Related Genes from a Context-Specific Protein Interaction Subnetwork.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 30;PP. Epub 2021 Apr 30.

Human aging is linked to many prevalent diseases. The aging process is highly influenced by genetic factors. Hence, it is important to identify human aging-related genes. Read More

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Optimal Employee Recruitment in Organizations under Attribute-Based Access Control.

ACM Trans Manag Inf Syst 2021 Jan;12(1)

Rutgers University, USA.

For any successful business endeavor, recruitment of required number of appropriately qualified employees in proper positions is a key requirement. For effective utilization of human resources, reorganization of such workforce assignment is also a task of utmost importance. This includes situations when the under-performing employees have to be substituted with fresh applicants. Read More

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January 2021

Tissue-Engineering the Fibrous Pancreatic Tumour Stroma Capsule in 3D Tumouroids to Demonstrate Paclitaxel Response.

Int J Mol Sci 2021 Apr 20;22(8). Epub 2021 Apr 20.

Centre for 3D Models of Health and Disease, Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, Charles Bell House, 43-45 Foley Street, London W1W 7TS, UK.

Pancreatic cancer is a unique cancer in that up to 90% of its tumour mass is composed of a hypovascular and fibrotic stroma. This makes it extremely difficult for chemotherapies to be delivered into the core of the cancer mass. We tissue-engineered a biomimetic 3D pancreatic cancer ("tumouroid") model comprised of a central artificial cancer mass (ACM), containing MIA Paca-2 cells, surrounded by a fibrotic stromal compartment. Read More

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Pilot Demonstration of a Strengthening Method for Steel-Bolted Connections Using Pre-Formable Carbon Fiber Cloth with VaRTM.

Materials (Basel) 2021 Apr 24;14(9). Epub 2021 Apr 24.

Department of Architecture and Civil Engineering, Toyohashi University of Technology, 1-1 Hibarigaoka, Tempaku-cho, Toyohashi, Aichi 441-8580, Japan.

In recent years, many seismic retrofitting methods have been performed to improve the structural performance and prevent the brittle failure of structural members. In the case of steel structures, slender seismic braces have been widely used for buildings, towers, and bridges. The brace connections should resist the full plastic axial tension load to ensure adequate plastic deformation performance for vibration energy absorption. Read More

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A Pilot Metabolomic Study on Myocardial Injury Caused by Chronic Alcohol Consumption-Alcoholic Cardiomyopathy.

Molecules 2021 Apr 9;26(8). Epub 2021 Apr 9.

Department of Forensic Pathology, School of Forensic Medicine, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang 110122, China.

Chronic alcohol consumption leads to myocardial injury, ventricle dilation, and cardiac dysfunction, which is defined as alcoholic cardiomyopathy (ACM). To explore the induced myocardial injury and underlying mechanism of ACM, the Liber-DeCarli liquid diet was used to establish an animal model of ACM and histopathology, echocardiography, molecular biology, and metabolomics were employed. Hematoxylin-eosin and Masson's trichrome staining revealed disordered myocardial structure and local fibrosis in the ACM group. Read More

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Hemi- and Homozygous Loss-of-Function Mutations in DSG2 (Desmoglein-2) Cause Recessive Arrhythmogenic Cardiomyopathy with an Early Onset.

Int J Mol Sci 2021 Apr 6;22(7). Epub 2021 Apr 6.

Erich and Hanna Klessmann Institute, Heart and Diabetes Center NRW, University Hospital of the Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.

About 50% of patients with arrhythmogenic cardiomyopathy (ACM) carry a pathogenic or likely pathogenic mutation in the desmosomal genes. However, there is a significant number of patients without positive familial anamnesis. Therefore, the molecular reasons for ACM in these patients are frequently unknown and a genetic contribution might be underestimated. Read More

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The Role of Speckle Tracking Echocardiography in the Evaluation of Common Inherited Cardiomyopathies in Children and Adolescents: A Systematic Review.

Diagnostics (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Population Health Sciences Department, University of Bristol, Bristol BS8 2PS, UK.

Speckle tracking echocardiography (STE) has gained importance in the evaluation of adult inherited cardiomyopathies, but its utility in children is not well characterized. We conducted a systematic review to evaluate the role of STE in pediatric inherited cardiomyopathies. PubMed, EMBASE, Web of Science, Scopus, CENTRAL and CINAHL databases were searched up to May 2020, for terms related to inherited cardiomyopathies and STE. Read More

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Detection of binding sites on SARS-CoV-2 Spike protein receptor-binding domain by molecular dynamics simulations in mixed solvents.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 29;PP. Epub 2021 Apr 29.

The novel SARS-CoV-2 uses the ACE2 (Angiotensin-Converting Enzyme 2) receptor as an entry point. Insights on S protein receptor-binding domain (RBD) interaction with ACE2 receptor and drug repurposing has accelerated drug discovery for the novel SARS-CoV-2 infection. Finding small molecule binding sites in the S protein and ACE2 interface is crucial in the search of effective drugs to prevent viral entry. Read More

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Echocardiographic diagnosis of atrial cardiomyopathy allows outcome prediction following pulmonary vein isolation.

Clin Res Cardiol 2021 Apr 29. Epub 2021 Apr 29.

Division of Cardiology and Angiology II, University Heart Center Freiburg-Bad Krozingen, Suedring 15, 79189, Bad Krozingen, Germany.

Background: Relevant atrial cardiomyopathy (ACM), defined as a left atrial (LA) low-voltage area ≥ 2 cm at 0.5 mV threshold on endocardial contact mapping, is associated with new-onset atrial fibrillation (AF), higher arrhythmia recurrence rates after pulmonary vein isolation (PVI), and an increased risk of stroke. The current study aimed to assess two non-invasive echocardiographic parameters, LA emptying fraction (EF) and LA longitudinal strain (LAS, during reservoir (LASr), conduit (LAScd) and contraction phase (LASct)) for the diagnosis of ACM and prediction of arrhythmia outcome after PVI. Read More

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Two Decades of the International Association for Cannabinoid Medicines: 20 Years of Supporting Research and Activities Toward the Medicinal Use of Cannabis and Cannabinoids.

Cannabis Cannabinoid Res 2021 Apr 15;6(2):82-87. Epub 2021 Apr 15.

International Association for Cannabinoid Medicines (IACM), Steinheim, Germany.

Emerged from the German Association for Cannabis as Medicine (ACM), a handful of enthusiastic medical doctors from Germany, Switzerland, and Austria supported by experts from other countries established the International Association for Cannabinoid Medicines (IACM) in March 2000. During the past 20 years until today, it evolved toward the most important scientific society for clinical research in the field of cannabis-based medicines. The overarching aim of the IACM is to advance the knowledge on cannabis, cannabinoids, the endocannabinoid system, and related topics especially with regard to their therapeutic potential, which would allow more patients to profit from a treatment with cannabis-based medicines and ease legislators to adopt their policies. Read More

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PAN: Personalized Annotation-based Networks for the Prediction of Breast Cancer Relapse.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 28;PP. Epub 2021 Apr 28.

The classification of clinical samples based on gene expression data is an important part of precision medicine. In this manuscript, we show how transforming gene expression data into a set of personalized (sample-specific) networks can allow us to harness existing graph-based methods to improve classifier performance. Existing approaches to personalized gene networks have the limitation that they depend on other samples in the data and must get re-computed whenever a new sample is introduced. Read More

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Association between varying cut-points of intermediate hyperglycemia and risk of mortality, cardiovascular events and chronic kidney disease: a systematic review and meta-analysis.

BMJ Open Diabetes Res Care 2021 Apr;9(1)

Rollins School of Public Health, Hubert Department of Global Health, Emory University, Atlanta, Georgia, USA.

Introduction: We conducted a systematic review and meta-analysis to evaluate the updated evidence regarding prediabetes for predicting mortality, macrovascular and microvascular outcomes.

Research Design And Methods: We identified English language studies from MEDLINE, PubMed, OVID and Cochrane database indexed from inception to January 31, 2020. Paired reviewers independently identified 106 prospective studies, comprising nearly 1. Read More

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Long-Term and Short-Term Prognostic Value of Circulating Soluble Suppression of Tumorigenicity-2 Concentration in Chronic Heart Failure: A Systematic Review and Meta-Analysis.

Cardiology 2021 Apr 26:1-8. Epub 2021 Apr 26.

School of Acupuncture and Tuina, Nanjing University of CM, Nanjing, China.

Introduction: Soluble suppression of tumorigenicity-2 (sST2) has been considered as a prognostic factor of cardiovascular disease. However, the prognostic value of sST2 concentration in chronic heart failure remains to be summarized.

Methods: We searched PubMed, Embase, and Web of Science for eligible studies up to January 1, 2020. Read More

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A Target HbA1c Between 7 and 7.7% Reduces Microvascular and Macrovascular Events in T2D Regardless of Duration of Diabetes: a Meta-Analysis of Randomized Controlled Trials.

Diabetes Ther 2021 Apr 24. Epub 2021 Apr 24.

Nightingale Hospital, Kolkata, India.

Introduction: The target glycated haemoglobin (HbA1c) at which micro- and macrovascular benefits may be derived in type 2 diabetes (T2D) has never been clearly outlined. This meta-analysis was conducted on 15 randomized controlled trials to highlight the association of HbA1c range with outcomes.

Methods: The association of different HbA1c cluster (intention-to-treat (ITT) and end-of-study [EOS]) ranges (≤ 6. Read More

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Preliminary Risk assessment for Acrylamide and Peripheral Neuropathy.

Robert M Park

Neurotoxicology 2021 Apr 20;85:10-17. Epub 2021 Apr 20.

U.S. National Institute for Occupational Safety and Health, Cincinnati, USA. Electronic address:

Acrylamide (ACM) is a high-volume industrial chemical with diverse uses in manufacturing, construction and laboratory research. ACM is a well-established neurotoxic agent causing peripheral neuropathy with impairment in the arms and legs of exposed workers, most thoroughly studied in Swedish tunnel workers exposed to ACM grouting. A quantitative risk assessment was performed to assess ACM risk to workers. Read More

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Network-based analysis of fatal comorbidities of COVID-19 and potential therapeutics.

IEEE/ACM Trans Comput Biol Bioinform 2021 Apr 23;PP. Epub 2021 Apr 23.

COVID-19 is a highly contagious disease caused by the SARS coronavirus 2 (SARS-CoV-2). The case-fatality rate is significantly higher in older patients and those with diabetes, cancer or cardiovascular disorders. The human proteins, angiotensin-converting enzyme 2 (ACE2), transmembrane protease serine 2 (TMPRSS2) and basigin (BSG), are involved in high-confidence host-pathogen interactions with SARS-CoV-2 proteins. Read More

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Effectiveness of medication in cluster headache.

BMC Neurol 2021 Apr 22;21(1):174. Epub 2021 Apr 22.

Institute of Information Systems, University of Applied Sciences Hof, Hof, Germany.

Background: The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up the possibility of investigating the effectiveness of acute medication on the basis of a large number of individual attacks instead of a simple survey of patients.

Methods: Data from 8369 cluster headache attacks, containing information about acute medication taken and the assessment of its effect, were collected from 133 participants using an online platform and a smartphone app. Read More

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