5,455 results match your criteria Acm Transactions On Database Systems[Journal]

Enriched Random Forest for High Dimensional Genomic Data.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 15;PP. Epub 2021 Jun 15.

Ensemble methods such as random forest works well on high-dimensional datasets. However, when the number of features is extremely large compared to the number of samples and the percentage of truly informative feature is very small, performance of traditional random forest decline significantly. To this end, we develop a novel approach that enhance the performance of traditional random forest by reducing the contribution of trees whose nodes are populated with less informative features. Read More

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Genome editing in cardiovascular diseases.

Indra Mani

Prog Mol Biol Transl Sci 2021 22;181:289-308. Epub 2021 Feb 22.

Department of Microbiology, Gargi College, University of Delhi, New Delhi, India. Electronic address:

Genetic modification at the molecular level in somatic cells, germline, and animal models requires for different purposes, such as introducing desired mutation, deletion of alleles, and insertion of novel genes in the genome. Various genome-editing tools are available to accomplish these alterations, such as zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR associated (Cas) system. CRISPR-Cas system is an emerging technology, which is being used in biological and medical sciences, including in the cardiovascular field. Read More

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February 2021

Alkaline Phosphatase-to-Albumin Ratio as a Novel Predictor of Long-Term Adverse Outcomes in Coronary Artery Disease Patients Who underwent PCI.

Biosci Rep 2021 Jun 14. Epub 2021 Jun 14.

Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: Alkaline phosphatase (ALP) and albumin (ALB) have been shown to be associated with coronary artery disease (CAD), and it has been reported that alkaline phosphatase-to-albumin ratio (AAR) is associated with the liver damage and poorer prognosis of patients with digestive system malignancy. Moreover, several previous studies showed that there was a higher incidence of malignancy in CAD patients. However, to our knowledge, the relationship between AAR and long-term adverse outcomes in CAD patients after undergoing percutaneous coronary intervention (PCI) has not been investigated. Read More

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The genetic architecture of Plakophilin 2 cardiomyopathy.

Genet Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.

Purpose: The genetic architecture of Plakophilin 2 (PKP2) cardiomyopathy can inform our understanding of its variant pathogenicity and protein function.

Methods: We assess the gene-wide and regional association of truncating and missense variants in PKP2 with arrhythmogenic cardiomyopathy (ACM), and arrhythmogenic right ventricular cardiomyopathy (ARVC) specifically. A discovery data set compares genetic testing requisitions to gnomAD. Read More

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IMCHGAN: Inductive Matrix Completion with Heterogeneous Graph Attention Networks for Drug-Target Interactions Prediction.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 11;PP. Epub 2021 Jun 11.

Computational approaches for prediction of drug-target interactions (DTIs) are highly desired in comparison to traditional biological experiments as its fast and low price. We present a novel Inductive Matrix Completion with Heterogeneous Graph Attention Network approach (IMCHGAN) for predicting DTIs. IMCHGAN first adopts a two-level neural attention mechanism approach to learn drug and target latent feature representations from the DTI heterogeneous network respectively. Read More

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Using Artificial Neural Networks to Model Errors in Biochemical Manipulation of DNA Molecules.

Jiaxiang Guo Hao Qi

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 11;PP. Epub 2021 Jun 11.

In recent years, the non-biological applications of DNA molecules have made considerable progress; most of these applications were performed in vitro, involving biochemical operations such as synthesis, amplification and sequencing. Because errors may occur with specific sequence patterns or experimental instruments, these biochemical operations are not completely reliable. Modeling errors in these biochemical procedures is an interesting research topic. Read More

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Shaking the beta-bulges.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 11;PP. Epub 2021 Jun 11.

-bulges are irregularities inside the -sheets. They represent more than 3% of the protein residues, i.e. Read More

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Use of artificial intelligence as an instrument of evaluation after stroke: a scoping review based on international classification of functioning, disability and health concept.

Top Stroke Rehabil 2021 Jun 11:1-16. Epub 2021 Jun 11.

Department of Neurology, Psychology and Psychiatry, Botucatu Medical School, Brazil.

: To understand the current practices in stroke evaluation, the main clinical decision support system and artificial intelligence (AI) technologies need to be understood to assist the therapist in obtaining better insights about impairments and level of activity and participation in persons with stroke during rehabilitation. : This scoping review maps the use of AI for the functional evaluation of persons with stroke; the context involves any setting of rehabilitation. Data were extracted from CENTRAL, MEDLINE, EMBASE, LILACS, CINAHL, PEDRO Web of Science, IEEE Xplore, AAAI Publications, ACM Digital Library, MathSciNet, and arXiv up to January 2021. Read More

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Universal approach for full endoscopic decompression and percutaneous transpedicular fixation of the lumbar spine: A medial central approach (ACM).

Medicine (Baltimore) 2021 Jun;100(23):e26310

Instituto de Columna Newro Spine.

Abstract: Cohort study.This study aimed to determine the effectiveness of the universal approach of full endoscopy and percutaneous transpedicular fixation via a medial central approach (ACM) performed to surgically treat patients with lumbar degenerative surgical pathologies.Alternatives to interventionist treatments available to patients with lumbar degenerative surgical pathologies are related to recovery from minimally invasive surgery. Read More

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Computing with many spaces: Generalizing projections for the digital geohumanities and GIScience.

Proc 1st ACM SIGSPATIAL Workshop Geospat Humanit (2017) 2017 Nov 7;2017:31-38. Epub 2017 Nov 7.

University of California, Berkeley, Berkeley, California.

The digital geohumanities-and geographic computation generally-have advanced greatly by representing phenomena within geographic coordinate systems. More specifically, most visualizations and analyses only proceed once data are rendered into a single coordinate system via geolocation and one or more projections. But does it follow that geographic computation should require all phenomena to be represented in Euclidean or spherical geometry in a singular, absolute, Newtonian space? We suggest an approach to pluralizing available to geographic computation. Read More

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November 2017

Translational and Rotational Arrow Cues (TRAC) Navigation Method for Manual Alignment Tasks.

ACM Trans Appl Percept 2020 Mar 10;17(1):1-19. Epub 2020 Feb 10.

University of Utah.

Many tasks in image-guided surgery require a clinician to manually position an instrument in space, with respect to a patient, with five or six degrees of freedom (DOF). Displaying the current and desired pose of the object on a 2D display such as a computer monitor is straightforward. However, providing guidance to accurately and rapidly navigate the object in 5-DOF or 6-DOF is challenging. Read More

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Sparse Deconvolution of Pulsatile Growth Hormone Secretion in Adolescents.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 10;PP. Epub 2021 Jun 10.

Growth hormone (GH) is secreted by cells in the anterior pituitary on two time scales: discrete pulses over minutes that occur within a 24-hr pattern. Secretion reflects the balance of stimulatory and inhibitory inputs from the hypothalamus and is influenced by gonadal steroids, stress, nutrition, and sleep/wake states. We propose a novel approach for the analysis of GH data and use this approach to quantify (i) the timing, amplitude and the number of GH pulses and (ii) GH infusion, clearance and basal secretion (i. Read More

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RNPredATC: a deep residual learning-based model with applications to the prediction of drug-ATC code association.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 10;PP. Epub 2021 Jun 10.

The ATC (Anatomical Therapeutic Chemical) code of a drug is a classification system designated by the World Health Organization Collaborating Center for Drug Statistics Methodology. Correctly identifying the potential ATC codes for drugs can accelerate drug development and reduce the cost of experiments. Several classifiers have been proposed in this regard. Read More

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Alternative and Augmentative Communication Technologies for Supporting Adults With Mild Intellectual Disabilities During Clinical Consultations: Scoping Review.

JMIR Rehabil Assist Technol 2021 Jun 9;8(2):e19925. Epub 2021 Jun 9.

Department of Computer and Information Sciences, University of Strathclyde, Glasgow, United Kingdom.

Background: People with intellectual disabilities (IDs) face significant communication barriers when accessing health care services; they find it difficult to identify and describe conditions clearly enough to support practitioners in making an accurate diagnosis. In addition, medical professionals generally have little knowledge and understanding of the needs of people with ID, which may result in the use of consultation techniques that do not cater to their patients' skills.

Objective: This review aims to identify and synthesize the literature on alternative and augmentative communication technologies that are used to support adults with mild ID during the exchange of information with medical practitioners. Read More

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Automated Detection of Stressful Conversations Using Wearable Physiological and Inertial Sensors.

Proc ACM Interact Mob Wearable Ubiquitous Technol 2020 Dec;4(4)

University of Memphis, Computer Science, Memphis, TN, USA.

Stressful conversation is a frequently occurring stressor in our daily life. Stressors not only adversely affect our physical and mental health but also our relationships with family, friends, and coworkers. In this paper, we present a model to automatically detect stressful conversations using wearable physiological and inertial sensors. Read More

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December 2020

Pathogenesis-based preexposure prophylaxis associated with a low risk of SARS-CoV-2 infection in healthcare workers at a designated COVID-19 hospital: a pilot study.

BMC Infect Dis 2021 Jun 7;21(1):536. Epub 2021 Jun 7.

North-Western State Medical University named after I.I. Mechnikov of Ministry of Health of Russian Federation, 41 Kirochnaya str, 191015, St. Petersburg, Russia.

Background: At present, no agents are known to be effective at preventing COVID-19. Based on current knowledge of the pathogenesis of this disease, we suggest that SARS-CoV-2 infection might be attenuated by directly maintaining innate pulmonary redox, metabolic and dilation functions using well-tolerated medications that are known to serve these functions, specifically, a low-dose aerosolized combination of glutathione, inosine and potassium.

Methods: From June 1 to July 10, 2020, we conducted a pilot, prospective, open-label, single-arm, single-center study to evaluate the safety and efficacy of preexposure prophylaxis (PrEP) with aerosolized combination medication (ACM) on the incidence of SARS-CoV-2 positivity in 99 healthcare workers (HCWs) at a hospital designated for treating COVID-19 patients. Read More

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Effect of hypoxia and nitrate supplementation on different high-intensity interval-training sessions.

Eur J Appl Physiol 2021 Jun 7. Epub 2021 Jun 7.

ISSUL, Institute of Sport Sciences and Physical Education (ISSEP), University of Lausanne, Lausanne, Switzerland.

Purpose: To test the hypothesis that interval-training (IHT) would be impaired by hypoxia to a larger extent than repeated-sprint training (RSH) and that dietary nitrate (NO) would mitigate the detrimental effect of hypoxia to a larger extent during IHT than RSH.

Methods: Thirty endurance-trained male participants performed IHT (6 × 1 min at 90%∆ with 1 min active recovery) and RSH (2 sets of 6 × 10 s "all-out" efforts with 20 s active recovery) on a cycle ergometer, allocated in one of three groups: normobaric hypoxia (~ 13% FO) + NO - HNO, n = 10; normobaric hypoxia + placebo - HPL, n = 10; normoxia (20.9% FO) + placebo - CON, n = 10. Read More

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Phenotypic Variability of a Pathogenic Mutation in an Italian Family Affected by Arrhythmogenic Cardiomyopathy and Juvenile Sudden Death: Considerations From Molecular Autopsy to Sport Restriction.

Front Cardiovasc Med 2021 20;8:635141. Epub 2021 May 20.

Cardiovascular Department, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Arrhythmogenic cardiomyopathy (ACM) is a genetic disorder with an estimated prevalence between 1:2,000 and 1:5,000 and is characterized by the fibrofatty replacement of cardiomyocytes that predisposes to malignant arrhythmias, heart failure, and sudden cardiac death. The diagnosis is based on the 2010 Task Force Criteria including family history, electrocardiographic traits and arrhythmogenic pattern, specific gene mutations, and structural and/or histological abnormalities. Most ACMs display an autosomal dominant mode of inheritance often with incomplete penetrance and variable expressivity. Read More

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MatchMaker: A Deep Learning Framework for Drug Synergy Prediction.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 4;PP. Epub 2021 Jun 4.

Drug combination therapies have been a viable strategy for the treatment of complex diseases such as cancer due to increased efficacy and reduced side effects. However, experimentally validating all possible combinations for synergistic interaction even with high-throughout screens is intractable due to vast combinatorial search space. Computational techniques can reduce the number of combinations to be evaluated experimentally by prioritizing promising candidates. Read More

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Adjuvant Versus Early Salvage Radiation Therapy for Men at High Risk for Recurrence Following Radical Prostatectomy for Prostate Cancer and the Risk of Death.

J Clin Oncol 2021 Jun 4:JCO2003714. Epub 2021 Jun 4.

Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA.

Purpose: Adjuvant compared with early salvage radiation therapy (sRT) following radical prostatectomy (RP) has not been shown to reduce progression-free survival in randomized controlled trials. However, these trials might have missed a benefit in men with adverse pathology at RP given that these men were under-represented and immortal time bias might have been present; herein, we investigate this possibility.

Methods: We evaluated the impact of adjuvant versus early sRT on all-cause mortality (ACM) risk in men with adverse pathology defined as positive pelvic lymph nodes (pN1) or pGleason score 8-10 prostate cancer (PC) and disease extending beyond the prostate (pT3/4). Read More

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Assessing the appropriateness of the Moving Epidemic Method and WHO Average Curve Method for the syndromic surveillance of acute respiratory infection in Mauritius.

PLoS One 2021 3;16(6):e0252703. Epub 2021 Jun 3.

World Health Organization Country Office for Mauritius, Port Louis, Republic of Mauritius.

Introduction: Mauritius introduced Acute respiratory infection (ARI) syndromic surveillance in 2007. The Moving Epidemic Method (MEM) and the World Health Organization Average Curve Method (WHO ACM) have been used widely in several countries to establish thresholds to determine the seasonality of acute respiratory infections. This study aimed to evaluate the appropriateness of these tools for ARI syndromic surveillance in Mauritius, where two or more waves are observed. Read More

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LUNAR Drug Screening for Novel Coronavirus Based on Representation Learning Graph Convolutional Network.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 3;PP. Epub 2021 Jun 3.

An outbreak of COVID-19 that began in late 2019 was caused by a novel coronavirus(SARS-CoV-2). It has become a global pandemic. As of June 9, 2020, it has infected nearly 7 million people and killed more than 400,000, but there is no specific drug. Read More

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Friends from the Future: A Scoping Review of Research into Robots and Computer Agents to Combat Loneliness in Older People.

Clin Interv Aging 2021 24;16:941-971. Epub 2021 May 24.

Department of Psychological Medicine, The University of Auckland, Auckland, New Zealand.

Background And Aim: Loneliness is a common problem in older adults and contributes to poor health. This scoping review aimed to synthesize and report evidence on the effectiveness of interventions using social robots or computer agents to reduce loneliness in older adults and to explore intervention strategies.

Methods: The review adhered to the Arksey and O'Malley process for conducting scoping reviews. Read More

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Document-level Chemical-induced Disease Relation Extraction via Hierarchical Representation Learning.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 2;PP. Epub 2021 Jun 2.

Over the past decades, Chemical-induced Disease (CID) relations have attracted extensive attention in biomedical community, reflecting wide applications in biomedical research and healthcare field. However, prior efforts fail to make full use of the interaction between local and global contexts in biomedical document, and the derived performance needs to be improved accordingly. In this paper, we propose a novel framework for document-level CID relation extraction. Read More

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A Parallelizable Model for Analyzing Cancer Tissue Heterogeneity.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 2;PP. Epub 2021 Jun 2.

The heterogeneous nature of a cell population creates a lot of challenges in cancer study. Determining the compositional breakup of a cell population from gene expression measurements efficiently is critical in cancer study. This paper presents a new model for analyzing heterogeneity in cancer tissue using Markov chain Monte Carlo (MCMC) algorithms; we aim to compute the proportion wise breakup of the cell population on a GPU. Read More

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An Alkyne Metathesis Based Approach to the Synthesis of the Anti-malarial Macrodiolide Samroiyotmycin A.

Angew Chem Int Ed Engl 2021 Jun 2. Epub 2021 Jun 2.

The University of Edinburgh, EaStCHEM School of Chemistry, David Brewster Road, EH9 3FJ, Edinburgh, UNITED KINGDOM.

We report the first total synthesis of samroiyotmycin A (1), a C2-symmetric 20-membered anti-malarial macrodiolide isolated from Streptomyces sp. The convergent synthetic strategy orchestrates bisalkyne fragment-assembly using an unprecedented Schӧllkopf-type condensation on a substituted β-lactone and an ambitious late-stage one-pot alkyne cross metathesis - ring-closing metathesis (ACM-RCAM) reaction. The demanding alkyne metathesis sequence is achieved using the latest generation of molybdenum alkylidynes endowed with a tripodal silanolate ligand framework. Read More

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Variants in Gene Cause Arrhythmogenic Cardiomyopathy.

Genes (Basel) 2021 May 22;12(6). Epub 2021 May 22.

Cardiology Unit, Department of Emergency and Critical Care, Tor Vergata Hospital, 00133 Rome, Italy.

Background: Arrhythmogenic Cardiomyopathy (ACM) is a disease of the cardiac muscle, characterized by frequent ventricular arrhythmias and functional/ structural abnormalities, mainly of the right ventricle. To date, 20 different genes have been associated with ACM and the majority of them encode for desmosomal proteins. In this study, we describe the characterization of two novel variants in gene, segregating in two ACM families. Read More

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Arrhythmogenic Left Ventricular Cardiomyopathy: Genotype-Phenotype Correlations and New Diagnostic Criteria.

J Clin Med 2021 May 20;10(10). Epub 2021 May 20.

Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy.

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease characterized by loss of ventricular myocardium and fibrofatty replacement, which predisposes to scar-related ventricular arrhythmias and sudden cardiac death, particularly in the young and athletes. Although in its original description the disease was characterized by an exclusive or at least predominant right ventricle (RV) involvement, it has been demonstrated that the fibrofatty scar can also localize in the left ventricle (LV), with the LV lesion that can equalize or even overcome that of the RV. While the right-dominant form is typically associated with mutations in genes encoding for desmosomal proteins, other (non-desmosomal) mutations have been showed to cause the biventricular and left-dominant variants. Read More

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An Ensemble of U-Net Models for Kidney Tumor Segmentation with CT images.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 1;PP. Epub 2021 Jun 1.

We present here the Arkansas AI-Campus solution method for the 2019 Kidney Tumor Segmentation Challenge (KiTS19). Our Arkansas AI-Campus team participated the KiTS19 Challenge for four months, from March to July of 2019. This paper provides a summary of our methods, training, testing and validation results for this grand challenge in biomedical imaging analysis. Read More

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CRCF: A Method of Identifying Secretory Proteins of Malaria Parasites.

IEEE/ACM Trans Comput Biol Bioinform 2021 Jun 1;PP. Epub 2021 Jun 1.

Malaria is a mosquito-borne disease that results in millions of cases and deaths annually. The development of a fast computational method that identifies secretory proteins of the malaria parasite is important for research on antimalarial drugs and vaccines. Thus, a method was developed to identify the secretory proteins of malaria parasites. Read More

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