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IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 10;PP. Epub 2022 Aug 10.

General-purpose protein structure embedding can be used for many important protein biology tasks, such as protein design, drug design and binding affinity prediction. Recent researches have shown that attention-based encoder layers are more suitable to learn high-level features. Based on this key observation, we propose a two-level general-purpose protein structure embedding neural network, called ContactLib-ATT. Read More

Adv Rheumatol 2022 Aug 9;62(1):31. Epub 2022 Aug 9.

Immunology Service of HUPES-UFBA, Post-Graduation Program in Health Science of the Federal University of Bahia, Praça Ramos de Queirós, s/n - Largo do Terreiro de Jesus, Salvador, Bahia, CEP 40026-010, Brazil.

Background: Joint pain in the absence or with little synovitis is observed in a large percentage of HTLV-1 infected subjects. As the virus infect CD4 + and CD8 + positive, macrophages and B cells an exaggerated production of pro-inflammatory cytokines is detected in these patients. However, the possible association of HTLV-1 infection with autoimmune diseases has not been documented definitively and the clinical characteristics of HTLV-1 associated arthropathy has not been defined. Read More

Vaccine 2022 Jun 27. Epub 2022 Jun 27.

CDC COVID-19 Response, 1600 Clifton Road NE, Atlanta, GA 30333, USA.

Introduction: Employer vaccination requirements have been used to increase vaccination uptake among healthcare personnel (HCP). In summer 2021, HCP were the group most likely to have employer requirements for COVID-19 vaccinations as healthcare facilities led the implementation of such requirements. This study examined the association between employer requirements and HCP's COVID-19 vaccination status and attitudes about the vaccine. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 8;PP. Epub 2022 Aug 8.

The drug discovery and development process is a long and expensive one, costing over 1 billion USD on average per drug and taking 10-15 years. To reduce the high levels of attrition throughout the process, there has been a growing interest in applying machine learning methodologies to various stages of drug discovery and development in the recent decade, especially at the earliest stage - identification of druggable disease genes. In this paper, we have developed a new tensor factorisation model to predict potential drug targets (genes or proteins) for treating diseases. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 8;PP. Epub 2022 Aug 8.

Protein-protein interactions (PPIs) play an essential role for most of biological processes in cells. Many computational algorithms have thus been proposed to predict PPIs. However, most of them heavily rest on the biological information of proteins while ignoring the latent structural features of proteins presented in a PPI network. Read More

BMC Cardiovasc Disord 2022 08 6;22(1):359. Epub 2022 Aug 6.

Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Background: Arrhythmogenic cardiomyopathy (ACM) is a heritable cardiac disease with two main features: electric instability and myocardial fibro-fatty replacement. There is no defined treatment except for preventing arrhythmias and sudden death. Detecting causative mutations helps identify the disease pathogenesis and family members at risk. Read More

Science 2022 08 5;377(6606):eabo1984. Epub 2022 Aug 5.

Heart and Diabetes Center NRW, Clinic for Thoracic and Cardiovascular Surgery, University Hospital of the Ruhr-University, 32545 Bad Oeynhausen, Germany.

Pathogenic variants in genes that cause dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) convey high risks for the development of heart failure through unknown mechanisms. Using single-nucleus RNA sequencing, we characterized the transcriptome of 880,000 nuclei from 18 control and 61 failing, nonischemic human hearts with pathogenic variants in DCM and ACM genes or idiopathic disease. We performed genotype-stratified analyses of the ventricular cell lineages and transcriptional states. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 4;PP. Epub 2022 Aug 4.

Growing studies have shown that miRNAs are inextricably linked with many human diseases, and a great deal of effort has been spent on identifying their potential associations. Compared with traditional experimental methods, computational approaches have achieved promising results. In this article, we propose a graph representation learning method to predict miRNA-disease associations. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 3;PP. Epub 2022 Aug 3.

Health monitoring embedded with intelligence is the demand of the day. In this era of a large population with the emergence of a variety of diseases, the demand for healthcare facilities is high. Yet there is scarcity of medical experts, technicians for providing healthcare to the people affected with some medical problem. Read More

Front Rehabilit Sci 2022 ;3

Rehabilitation Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Background: There is increased interest in using artificial intelligence (AI) to provide participation-focused pediatric re/habilitation. Existing reviews on the use of AI in participation-focused pediatric re/habilitation focus on interventions and do not screen articles based on their definition of participation. AI-based assessments may help reduce provider burden and can support operationalization of the construct under investigation. Read More

ACM Trans Access Comput 2022 ;15

University of Maryland, College Park, Maryland, USA.

Clinical researchers have identified sensory changes people with age-related cognitive changes, such as dementia and mild cognitive impairment, experience that are different from typical age-related sensory changes. Technology designers and researchers do not yet have an understanding of how these unique sensory changes affect technology use. This work begins to bridge the gap between the clinical knowledge of sensory changes and technology research and design through interviews with people with mild to moderate dementia, mild cognitive impairment, subjective cognitive decline, and healthcare professionals. Read More

Int J Obes (Lond) 2022 Aug 1. Epub 2022 Aug 1.

Charles Perkins Centre, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, NSW, Australia.

Background: The relationship between joint changes in physical activity and adiposity with mortality is not well understood. We examined the association of changes in these two established risk factors with all-cause (ACM), cardiovascular disease (CVD), and cancer mortality.

Methods: We used longitudinal data from Taiwan's MJ Cohort, comprising 116,228 general population adults recruited from 1998-2013 with repeated measures 4. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 1;PP. Epub 2022 Aug 1.

In the area of medical image segmentation, the spatial information can be further used to enhance the image segmentation performance. And the 3D convolution is mainly used to better utilize the spatial information. However, how to better utilize the spatial information in the 2D convolution is still a challenging task. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 1;PP. Epub 2022 Aug 1.

With the development of plant phenomics, the identification of plant diseases from leaf images has become an effective and economic approach in plant disease science. Among the methods of plant diseases identification, the convolutional neural network (CNN) is the most popular one for its superior performance. However 5, CNN's representation power is still a challenge in dealing with small datasets, which greatly affects its popularization. Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Aug 1;PP. Epub 2022 Aug 1.

MicroRNAs (miRNAs) are short endogenous non-encoding RNA molecules (22nt) that have a vital role in many biological and molecular processes inside the human body. Abnormal and dysregulated expressions of miRNAs are correlated with many complex disorders. Time-consuming wet-lab biological experiments are costly and labour-intensive. Read More

PLoS One 2022 1;17(8):e0266263. Epub 2022 Aug 1.

Vetsuisse Faculty, Division of Neurological Sciences, Department of Clinical Research and Veterinary Public Health, University of Bern, Bern, Switzerland.

Equine insect bite hypersensitivity (IBH) is the most common skin disease affecting horses. It is described as an IgE-mediated, Type I hypersensitivity reaction to salivary gland proteins of Culicoides insects. Together with Th2 cells, epithelial barrier cells play an important role in development of Type I hypersensitivities. Read More

Sci Total Environ 2022 Jul 26:157275. Epub 2022 Jul 26.

Thermal Physics, Acoustics and Environment Department in Building Research Institute (ITB), st. Filtrowa 1, Warsaw 00-611, Poland. Electronic address:

The results of a quantitative analysis of asbestos content in the ground with varying degrees of concentration of this mineral as a result of natural phenomena such as rock weathering, contamination by the manufacture of asbestos and cement products, and the many years of use of "eternit roofs" are presented. Preliminary thermal treatment, soil grinding and sieving were used for the determinations, followed by electrostatic separation in order to obtain the concentration of asbestos in a smaller volume. It was used for microscopic preparations for the identification and planimetry of asbestos. Read More

Pharm Res 2022 Jul 29. Epub 2022 Jul 29.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, 201203, People's Republic of China.

Purpose: Recently, docetaxel (DTX) micelles based on retinoic acid derivative surfactants showed lower systemic toxicity and bioequivalence to polysorbate-solubilized docetaxel (Taxotere®) in a phase II clinical study. However, the poor stability of these surfactants in vitro and in vivo led to extremely harsh storage conditions with methanol, and the formed micelles were quickly disintegrated with rapid drug burst release in vivo. To further enhance the stability and accumulation in tumors of DTX micelles, a novel surfactant based on acitretin (ACMeNa) was synthesized and used to prepare DTX micelles to improve anti-tumor efficiency. Read More

Prof Case Manag 2022 Sep-Oct 01;27(5):248-249

Marianne McHale Ramey, RN, ACM, CPUR, is the senior partner of Phoenix Medical Management, Inc., Flagstaff, AZ. She began her career as a practicing nurse and held several leadership positions in hospital nursing departments and case management programs. With her strength in case management interim leadership, Marianne has successfully led care management transformation projects in New Hampshire, Arizona, Tennessee, California, New York, Michigan, and Kansas hospitals. Before joining Phoenix, Marianne served as a management consultant with Johnson & Johnson in their Resource Management Consulting and Services division. Marianne is coauthor of the text The Leader's Guide to Hospital Case Management.

JMIR Diabetes 2022 Jul 28;7(3):e28153. Epub 2022 Jul 28.

Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield, United Kingdom.

Background: Most diabetes management involves self-management. Effective self-management of the condition improves diabetes control, reduces the risk of complications, and improves patient outcomes. Mobile apps for diabetes self-management (DSM) can enhance patients' self-management activities. Read More

JMIR Res Protoc 2022 Jul 28;11(7):e35749. Epub 2022 Jul 28.

College of Information Sciences and Technology, The Pennsylvania State University, University Park, PA, United States.

Background: Substance use and use disorders in the United States have had significant and devastating impacts on individuals and communities. This escalating substance use crisis calls for urgent and innovative solutions to effectively detect and provide interventions for individuals in times of need. Recent mobile health (mHealth)-based approaches offer promising new opportunities to address these issues through ubiquitous devices. Read More

BMJ Open 2022 07 27;12(7):e057562. Epub 2022 Jul 27.

Center for Clinical Research, Vasteras, Faculty of Medicine, Uppsala University, Uppsala, Sweden

Objective: To assess the impact of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) on long-term all-cause mortality (ACM) in patients with acute myocardial infarction (AMI) and controls.

Design: Matched case-control study with 8-year follow-up.

Setting: Vastmanland County Hospital, Vasteras, Sweden. Read More

Sensors (Basel) 2022 Jul 20;22(14). Epub 2022 Jul 20.

Institute of Remote Sensing Satellite, China Academy of Space Technology, Beijing 100094, China.

Nowadays low Earth orbit (LEO) Earth observation (EO) satellites commonly use constant coding modulation (CCM) or variable coding modulation (VCM) schemes for data transmission to ground stations (G/S). Compared with CCM and VCM, the adaptive coding modulation (ACM) could further improve the data throughput of the link by making full use of link resource and the time-varying characteristics of atmospheric attenuation. In order to comprehensively study the data transmission performance, one new index which could be utilized as a quantitative index for the satellite-to-ground data transmission scheme selection, the transmission efficiency factor (TEF) of LEO satellites is proposed and defined as "the product of the link availability and the average useful data rate". Read More

IEEE/ACM Trans Comput Biol Bioinform 2022 Jul 26;PP. Epub 2022 Jul 26.

The Industrial Internet of Things (IIoT) has been introduced in an era of increasingly broad potentials in the medical industry. In recent years, IIoT-based healthcare applications have grown in popularity, with the majority of them relying on Wireless Body Area Network (WBAN) for flexibility. There have been a few recent works that have investigated SDN-based fog architecture for constructing smart healthcare systems. Read More

J Big Data 2022 20;9(1):96. Epub 2022 Jul 20.

Graduate School of Applied Statistics, National Institute of Development Administration (NIDA), 148 SeriThai Rd., Bangkapi, Bangkok, 10240 Thailand.

Introduction: The emergence of automated machine learning or AutoML has raised an interesting trend of no-code and low-code machine learning where most tasks in the machine learning pipeline can possibly be automated without support from human data scientists. While it sounds reasonable that we should leave repetitive trial-and-error tasks of designing complex network architectures and tuning a lot of hyperparameters to AutoML, leading research using AutoML is still scarce. Thereby, the overall purpose of this case study is to investigate the gap between current AutoML frameworks and practical machine learning development. Read More

BJU Int 2022 Jul 25. Epub 2022 Jul 25.

Department of Urology, La Jolla, CA; UC San Diego School of Medicine, La Jolla, USA; 2Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan; 3Department of Urology, Emory University School of Medicine, Atlanta, USA.

Objectives: To evaluate effects of worsening surgically induced chronic kidney disease (CKD-S) on oncologic and non-oncologic survival outcomes in renal cell carcinoma (RCC).

Methods: We performed a retrospective analysis of patients who underwent Partial (PN) or Radical Nephrectomy (RN) and were free of preoperative CKD (eGFR≥60 mL/min/1.73m2). Read More

J Environ Manage 2022 Jul 18;319:115716. Epub 2022 Jul 18.

Urban Analytics and Complex Systems (UACS) Consulting, Queensland, Australia; Griffith School of Engineering and Built Environment, Griffith University, Australia.

Asbestos has been used by automobile, construction, manufacturing, power, and chemical industries for many years due to its particular properties, i.e. high tensile strength, non-flammable, thermal and electrical resistance and stability, and chemical resistance. Read More

JMIR Diabetes 2022 Jul 21;7(3):e34699. Epub 2022 Jul 21.

Department of Electrical & Computer Engineering, Hellenic Mediterranean University, Heraklion, Greece.

Background: Diabetes is a chronic condition that necessitates regular monitoring and self-management of the patient's blood glucose levels. People with type 1 diabetes (T1D) can live a productive life if they receive proper diabetes care. Nonetheless, a loose glycemic control might increase the risk of developing hypoglycemia. Read More

J Glob Health 2022 Jul 30;12:04041. Epub 2022 Jul 30.

Department of Cardiovascular Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.

Background: Alcoholic cardiomyopathy (ACM) remains a significant public health issue with a growing global burden. The burden of ACM in China and different regions remains poorly understood.

Methods: Data on ACM deaths, disability-adjusted life years (DALYs), the corresponding global age-standardized death rate (ASDR), age-standardized DALY rate and estimated annual percentage change (EAPC) were analysed based on age, sex, socio-demographic index (SDI) quintiles, different regions and in China from the Global Burden of Disease (GBD) study 2019. Read More

Adv Sci (Weinh) 2022 Jul 20:e2201696. Epub 2022 Jul 20.

Department of Anesthesiology and Intensive Care Unit, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200092, China.

Acute lung injury (ALI) is a significant contributor to the morbidity and mortality of sepsis. Characterized by uncontrolled inflammation and excessive inflammatory cells infiltration in lung, ALI has been exacerbated by impaired efferocytosis (clearance of apoptotic cells by macrophages). Through specific receptor recognition and activation of downstream signaling, efferocytic macrophages promote resolution of inflammation by efficiently engulfing dying cells, avoiding the consequent release of cellular inflammatory contents. Read More