18,681 results match your criteria Acinetobacter


Bacteriological water quality and biofilm formation in the treatment system of the hemodialysis unit in Tlemcen, Algeria.

Semin Dial 2020 Jul 11. Epub 2020 Jul 11.

Laboratoire de Microbiologie Appliquée à l'Agroalimentaire, au Biomédical et à l'Environnement (LAMAABE), Faculty of Nature and Life, Earth and Universe Sciences, University of Tlemcen, Tlemcen, Algeria.

Objective: To evaluate and compare the microbiological quality of osmosis water at the distribution loop, at the dialysis generator inlet and to study the prevalence of biofilm in the tubing.

Methods: Microbiological analysis of 20 water loop samples, 10 water samples were taken at the machine entry and 10 pipe segments from tubing connecting the machines to the loop was done.

Results: The bacterial enumeration results of the loop water vary from 90 to 150 CFU/mL, while the average number of bacteria at the entry of the machines was 182 CFU/mL. Read More

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http://dx.doi.org/10.1111/sdi.12898DOI Listing

Regulation of growth, intestinal microflora composition and expression of immune-related genes by dietary supplementation of Streptococcus faecalis in blunt snout bream (Megalobrama amblycephala).

Fish Shellfish Immunol 2020 Jul 8. Epub 2020 Jul 8.

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing, 210095, People's Republic of China.

A 10-week feeding trial was performed to investigate the effects of Streptococcus faecalis on the growth, intestinal microflora composition and expression of immune-related genes of blunt snout bream (Megalobrama amblycephala). Fish (46.32 ± 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2020.07.011DOI Listing

Structure and diversity of native bacterial communities in soils contaminated with polychlorinated biphenyls.

AMB Express 2020 Jul 10;10(1):124. Epub 2020 Jul 10.

Tecnológico Nacional de México/IT de Tuxtla Gutiérrez, Carretera Panamericana Km, 1080, CP 29050, Tuxtla Gutiérrez, Chiapas, Mexico.

Persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs) are a group of high-risk synthetic substances for human and environmental health. Currently, the study of sites contaminated by the spillage of equipment PCBs containing have been considered targeted areas for the study of bacterial communities with potential for PCBs degradation. There in isolation of bacterial strains is vital for use in biodegradable processes, such as bacterial bioaugmentation, which accelerates the development of phenomena such as natural attenuation of contaminated sites. Read More

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http://dx.doi.org/10.1186/s13568-020-01058-8DOI Listing

Pollution profiles of antibiotic resistance genes associated with airborne opportunistic pathogens from typical area, Pearl River Estuary and their exposure risk to human.

Environ Int 2020 Jul 6;143:105934. Epub 2020 Jul 6.

Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

To reveal the selective pressures of near-shore human activities on marine and continental bioaerosols, the pollution profile and potential exposure risk of airborne pathogens and antibiotic-resistance genes (ARGs) in Pearl River Estuaries (113.52 E, 22.69 N), a transitional zone between marine and continental environments, were fully explored. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105934DOI Listing

Disinfection of N95 masks artificially contaminated with SARS-CoV-2 and ESKAPE bacteria using hydrogen peroxide plasma: impact on the reutilization of disposable devices.

Am J Infect Control 2020 Jul 6. Epub 2020 Jul 6.

División de Investigación, Hospital Juárez de México, Ciudad de México. Electronic address:

Introduction: One of the serious consequences of the SARS-CoV-2 pandemic is the shortage of protective equipment for health personnel. N95 masks are considered one of the essential protective equipment in the management of patients with COVID-19. The shortage of N95 masks implies potential health risks for health personnel and significant economic losses for the health institution. Read More

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http://dx.doi.org/10.1016/j.ajic.2020.06.216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336929PMC

Detection of New Delhi Metallo-β-lactamase 1 and Cephalosporin Resistance Genes Among Carbapenem-Resistant Enterobacteriaceae in Water Bodies Adjacent to Hospitals in India.

Curr Microbiol 2020 Jul 8. Epub 2020 Jul 8.

Department of Aquatic Animal Health Management, Kerala University of Fisheries and Ocean Studies, Kochi, Kerala, India.

The prevalence of carbapenem resistance among bacterial isolates from selected water bodies receiving hospital effluents and adjoining aquaculture farms in Kerala, India, was studied. Klebsiella pneumoniae followed by Escherichia coli, Klebsiella oxytoca, Enterobacter aerogenes and Acinetobacter baumannii were the predominant isolates. Antibiotic sensitivity of these isolates was determined by Kirby-Bauer disc diffusion method. Read More

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http://dx.doi.org/10.1007/s00284-020-02107-yDOI Listing

Antimicrobial peptides-loaded smart chitosan hydrogel: Release behavior and antibacterial potential against antibiotic resistant clinical isolates.

Int J Biol Macromol 2020 Jul 5. Epub 2020 Jul 5.

Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

In this study, we synthesized thermo-responsive chitosan (TCTS) hydrogels, and loaded with different concentrations of antimicrobial peptide (AMP) (0, 4, 8 and 16 μg·ml) to fabricate an antibacterial wound dressing against resistant clinical isolates. Physico-chemical properties, release behavior, cytobiocompatibility and antibacterial activity of the AMP-TCTS hydrogels against standard strain and resistant Acinetobacter baumannii were fully determined in vitro. The TCTS-40% β-glycerolphosphate hydrogels showed a gelation time of 15 min at 37 °C. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.07.011DOI Listing

Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study.

Allergy Asthma Immunol Res 2020 Sep;12(5):792-805

Institute of MD Healthcare Inc., Seoul, Korea.

Purpose: Associations between a wide variety of diseases and the microbiome have been extensively verified. Recently, there has been a rising interest in the role the microbiome plays in atopic dermatitis (AD). Furthermore, metagenomic analysis of microbe-derived extracellular vesicles (EVs) has revealed the importance and relevance of microbial EVs in human health. Read More

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http://dx.doi.org/10.4168/aair.2020.12.5.792DOI Listing
September 2020
3.084 Impact Factor

Data retrieved from evaluation of vaccine potential of ZnuD protein in .

Data Brief 2020 Aug 20;31:105892. Epub 2020 Jun 20.

Department of Biotechnology, Semnan University, Semnan, Iran.

The nosocomial is one of the most opportunistic pathogens that resists almost a broad range of antibiotics. Some bacterial metal acquisition systems are introduced as potential virulence factors in pathogen-host interaction.  Bacterial zinc uptake (Znu) systems are critical transporters that play a major role in the survival of the pathogen and the establishment of infections. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327815PMC

Efficacy of Acacia nilotica aqueous extract in treating biofilm-forming and multidrug resistant uropathogens isolated from patients with UTI syndrome.

Sci Rep 2020 Jul 7;10(1):11125. Epub 2020 Jul 7.

Department of Botany and Microbiology, Faculty of Science, South Valley University, Qena, 83523, Egypt.

Escherichia coli is the dominant bacterial cause of UTI among the uropathogens in both developed and developing countries. This study is to investigate the effect of Acacia nilotica aqueous extract on the survival and biofilm of isolated pathogens to reduce UTIs diseases. A total of 170 urine samples were collected from Luxor general hospital and private medical analysis laboratories in Luxor providence, Egypt. Read More

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http://dx.doi.org/10.1038/s41598-020-67732-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7341837PMC

Assembly and regulation of the chlorhexidine-specific efflux pump AceI.

Proc Natl Acad Sci U S A 2020 Jul 7. Epub 2020 Jul 7.

Physical and Theoretical Chemistry Laboratory, Department of Chemistry, University of Oxford, Oxford OX1 3QZ, United Kingdom

Few antibiotics are effective against , one of the most successful pathogens responsible for hospital-acquired infections. Resistance to chlorhexidine, an antiseptic widely used to combat , is effected through the proteobacterial antimicrobial compound efflux (PACE) family. The prototype membrane protein of this family, AceI ( chlorhexidine efflux protein I), is encoded for by the gene and is under the transcriptional control of AceR ( chlorhexidine efflux protein regulator), a LysR-type transcriptional regulator (LTTR) protein. Read More

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http://dx.doi.org/10.1073/pnas.2003271117DOI Listing

Amiodarone that has antibacterial effect against human pathogens may represent a novel catheter lock.

Acta Microbiol Immunol Hung 2020 Jul 6. Epub 2020 Jul 6.

1Department of Medical Microbiology, Medical School, University of Pecs, Pecs, Hungary.

Infection is one of the most feared hospital-acquired complications. Infusion therapy is frequently administered through a central line. Infusions facilitating bacterial growth may be a source of central line-associated bloodstream infections. Read More

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http://dx.doi.org/10.1556/030.2020.01144DOI Listing

Coupling 16s rDNA and untargeted mass spectrometry for milk microbial composition and metabolites from dairy cows with clinical and subclinical mastitis.

J Agric Food Chem 2020 Jul 6. Epub 2020 Jul 6.

The internal environment of the cow's udder directly affects the udder health and milk quality. The 16S rDNA sequencing and liquid chromatography-mass spectrometry (LC-MS) methods were used to investigate the significant differences in milk microbial diversity and metabolites among healthy (H), subclinical mastitis (SM) and clinical mastitis (CM) cows. Results uncovered more than 16 and 192 differently abundant microbiota in phyla and genera level, respectively, and 673 different levels of metabolites enriched in 20 pathways in milk among the 3 groups. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c03738DOI Listing

Dynamics of the lung microbiome in intensive care patients with chronic obstructive pulmonary disease and community-acquired pneumonia.

Sci Rep 2020 Jul 6;10(1):11046. Epub 2020 Jul 6.

Department of Life Sciences, National Chung Hsing University, 145 Xingda Rd., South Dist., Taichung, 402, Taiwan.

Little is known about the composition and clinical implications of lung microbiome in patients with chronic obstructive pulmonary disease (COPD) and community-acquired pneumonia requiring invasive mechanical ventilation and intensive care unit admission. Therefore, this study aimed to explore the longitudinal changes in microbial airway composition and its variations between COPD patients with different weaning outcomes. Fifty-one endotracheal aspirate samples from 21 participants and 5 saline samples were collected as the patient and control group, respectively. Read More

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http://dx.doi.org/10.1038/s41598-020-68100-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338533PMC

The first nationwide multicenter study of Acinetobacter baumannii recovered in Serbia: emergence of OXA-72, OXA-23 and NDM-1-producing isolates.

Antimicrob Resist Infect Control 2020 Jul 6;9(1):101. Epub 2020 Jul 6.

Institute of Microbiology and Immunology, Medical Faculty, University of Belgrade, Doktora Subotica starijeg 1, Belgrade, 11000, Serbia.

Background: The worldwide emergence and clonal spread of carbapenem-resistant Acinetobacter baumannii (CRAB) is of great concern. The aim of this nationwide study was to investigate the prevalence of CRAB isolates in Serbia and to characterize underlying resistance mechanisms and their genetic relatedness.

Methods: Non-redundant clinical samples obtained from hospitalized patients throughout Serbia were included in the prospective, observational, multicenter study conducted from January to June 2018. Read More

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http://dx.doi.org/10.1186/s13756-020-00769-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338125PMC

Antimicrobial and Antifungal Activity of Rare Substituted 1,2,3-Thiaselenazoles and Corresponding Matched Pair 1,2,3-Dithiazoles.

Antibiotics (Basel) 2020 Jul 1;9(7). Epub 2020 Jul 1.

Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

We report our investigations into the underlying differences between 1,2,3-dithiazole and their ultra-rare counterpart, 1,2,3-thiaselenazole. This rare 1,2,3-thiaselenazole chemotype was afforded by sulfur extrusion and selenium insertion into the preconstructed 1,2,3-dithiazoles. We built a library of matched paired compounds to compare and contrast the two ring systems. Read More

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http://dx.doi.org/10.3390/antibiotics9070369DOI Listing

Emerging Resistance of Gram Negative Pathogens in Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 6;41(4):480-495. Epub 2020 Jul 6.

Division of Pulmonary Diseases and Critical Care Medicine, University of Texas Health, San Antonio, San Antonio, Texas.

In recent decades, there has been a growing interest about the role of gram negative bacteria in community-acquired pneumonia (CAP), especially , , and . The prevalence of these pathogens differs largely according to the local ecology and the geographical location. Identifying gram negative bacteria, and in particular resistant gram negative bacteria, is of paramount importance in patients with CAP because these pathogens are associated with higher clinical severity and unfavorable outcomes. Read More

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http://dx.doi.org/10.1055/s-0040-1709137DOI Listing

Spinal arachnoiditis followed by intrathecal tigecycline therapy for central nervous system infection by extremely drug-resistant .

J Int Med Res 2020 Jul;48(7):300060520920405

Department of Neonatology, Zhongshan City People's Hospital, Zhongshan, China.

In prior research, intrathecal tigecycline was successfully used to treat central nervous system infection by extensively drug-resistant . However, little is known about its safe dose and adverse reactions. This study reports the case of a 28-year-old male patient who was diagnosed with central nervous system infection by extensively drug-resistant after the removal of a ventriculoperitoneal shunt. Read More

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http://dx.doi.org/10.1177/0300060520920405DOI Listing

Green Synthesis of AuNPs by sp. GWRVA25: Optimization, Characterization, and Its Antioxidant Activity.

Front Chem 2020 18;8:474. Epub 2020 Jun 18.

Department of Microbiology, Savitribai Phule Pune University, Pune, India.

Bacteriogenic synthesis of metal nanoparticles is ecofriendly and greatly influenced by physico-chemical reaction parameters with respect to shape and size. Thus, present work aimed to synthesize and optimization of bacteriogenic gold nanoparticles (AuNPs) and study their antioxidant activity. sp. Read More

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http://dx.doi.org/10.3389/fchem.2020.00474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314902PMC

Linking Short-Chain N-Acyl Homoserine Lactone-Mediated Quorum Sensing and Replant Disease: A Case Study of .

Front Plant Sci 2020 17;11:787. Epub 2020 Jun 17.

College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, China.

, a perennial medicinal plant, suffers from severe replant disease under consecutive monoculture. The rhizosphere microbiome is vital for soil suppressiveness to diseases and for plant health. Moreover, N-acyl homoserine lactone (AHL)-mediated quorum sensing (QS) regulates diverse behavior in rhizosphere-inhabiting and plant pathogenic bacteria. Read More

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http://dx.doi.org/10.3389/fpls.2020.00787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311668PMC
June 2020
3.637 Impact Factor

Structure and Evolution of Plasmids.

Front Microbiol 2020 18;11:1283. Epub 2020 Jun 18.

Programa de Genómica Evolutiva, Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico.

is an emergent bacterial pathogen that provokes many types of infections in hospitals around the world. The genome of this organism consists of a chromosome and plasmids. These plasmids vary over a wide size range and many of them have been linked to the acquisition of antibiotic-resistance genes. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315799PMC

Antibacterial and Synergistic Effects of Herbal Extracts in Combination with Amikacin and Imipenem Against Multidrug-Resistant Isolates of Acinetobacter.

Curr Microbiol 2020 Jul 4. Epub 2020 Jul 4.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Acinetobacter species are defined as multidrug-resistant pathogens and the development of resistance against antimicrobials is a major problem in the treatment of infections caused by them. This study aimed to evaluate the antibacterial activity of aqueous and methanol extracts of Salvia chorassanica and Artemisia khorassanica on multidrug-resistant Acinetobacter isolates and also examining the interaction of the methanol extract of the plants with the combination of amikacin and imipenem. First, the presence of adeI and adeB genes in bacterial isolates was investigated. Read More

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http://dx.doi.org/10.1007/s00284-020-02105-0DOI Listing

sp. nov. and sp. nov., isolated from raw meat.

Int J Syst Evol Microbiol 2020 Jul 3. Epub 2020 Jul 3.

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy of the University of Gothenburg, Gothenburg, Sweden.

The taxonomic status of six strains of obtained from meat samples, collected from supermarkets in Porto, Portugal, was investigated using polyphasic analysis. Partial sequence similarities lower than 95 % to other species with validly published names led to the hypothesis that these strains represented novel species. This was confirmed based on comparative multilocus sequence analysis, which included the , and 16S rRNA genes, revealing that these strains represented two coherent lineages that were distinct from each other and from all known species. Read More

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http://dx.doi.org/10.1099/ijsem.0.004311DOI Listing

Detecting carbapenem-resistant (CRAB) carriage: Which body site should be cultured?

Infect Control Hosp Epidemiol 2020 Jun 19:1-3. Epub 2020 Jun 19.

National Institute for Antibiotic Resistance and Infection Control, Ministry of Health, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

We compared the yield of culturing various body sites to detect carriage of carbapenem-resistant Acinetobacter baumannii (CRAB). Culturing the skin using a premoistened sponge, with overnight enrichment and plating on CHROMagar MDR Acinetobacter, had the highest yield: 92%. Skin is satisfactory as a single site for active surveillance of CRAB. Read More

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http://dx.doi.org/10.1017/ice.2020.197DOI Listing

Trehalose-6-phosphate mediated phenotypic change in Acinetobacter baumannii.

Environ Microbiol 2020 Jul 2. Epub 2020 Jul 2.

Department of Molecular Microbiology & Bioenergetics, Institute of Molecular Biosciences, Goethe-University Frankfurt am Main, Germany.

The stress protectant trehalose is synthesized in Acinetobacter baumannii from UPD-glucose and glucose-6-phosphase via the OtsA/OtsB pathway. Previous studies proved that deletion of otsB led to a decreased virulence, the inability to grow at 45 °C and a slight reduction of growth at high salinities indicating that trehalose is the cause of these phenotypes. We have questioned this conclusion by producing ∆otsA and ∆otsBA mutants and studying their phenotypes. Read More

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http://dx.doi.org/10.1111/1462-2920.15148DOI Listing

Bacteria from industrial waste: potential producers of polyhydroxyalkanoates (PHAs) in Manizales, Colombia.

Environ Monit Assess 2020 Jul 2;192(7):480. Epub 2020 Jul 2.

Grupo de Investigación GEBIOME, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas y Naturales, Universidad de Caldas, Calle 65 No. 26-10 Apartado Aéreo 275 Manizales, Caldas, Colombia.

Polymers are currently used in the industry as raw material, yet they are rapidly eliminated and largely contaminate the environment. To address this issue, there is a special interest in biodegradable polymers, namely, polyhydroxyalkanoates (PHAs), produced by microorganisms. This study identifies PHA-producing bacteria from two industrial wastewaters of Manizales, Colombia. Read More

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http://dx.doi.org/10.1007/s10661-020-08461-5DOI Listing

Emergence of multidrug-resistant non-fermentative gram negative bacterial infection in hospitalized patients in a tertiary care center of Nepal.

BMC Res Notes 2020 Jul 2;13(1):319. Epub 2020 Jul 2.

Department of Clinical Microbiology, Institute of Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.

Objective: This study was designed for the characterization and establishment of antibiotic susceptibility profiles of non-fermentative gram negative bacteria isolated from hospitalized patients in a tertiary care hospital of Nepal.

Results: A total of 402 non-fermentative gram negative bacteria was isolated in 1486 culture-positive cases from 6216 different clinical samples obtained from hospitalized patients. Among total non-fermentative gram negative bacterial isolates, the highest number was recovered from specimens collected from lower respiratory tract infections (n = 173, 43. Read More

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http://dx.doi.org/10.1186/s13104-020-05163-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330544PMC

Colistin heteroresistance in carbapenem-resistant Acinetobacter baumannii clinical isolates from a Thai university hospital.

World J Microbiol Biotechnol 2020 Jul 1;36(7):102. Epub 2020 Jul 1.

Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.

Colistin is the last resort for the treatment of infections with carbapenem-resistant (CR) Gram-negative bacteria particularly Acinetobacter baumannii (CRAB). Currently, both colistin-resistant and -heteroresistant A. baumannii isolates have been reported globally. Read More

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http://dx.doi.org/10.1007/s11274-020-02873-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327205PMC

Molecular Detection of Carbapenemase-Encoding Genes in Multidrug-Resistant Clinical Isolates in South Africa.

Int J Microbiol 2020 13;2020:7380740. Epub 2020 Jun 13.

School of Chemistry and Physics, College of Agriculture Engineering and Science, University of KwaZulu-Natal, 2nd Floor, Francis Stock Building, Howard College Campus, UKZN, Durban 4041, South Africa.

Introduction: Carbapenem-resistant has been responsible for an increasing number of hospital-acquired infections globally. The study investigated the prevalence of carbapenemase-encoding genes in clinical multidrug-resistant strains.

Materials And Methods: A total of 100 nonduplicate multidrug-resistant strains were cultured from clinical samples obtained from healthcare facilities in the O. Read More

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http://dx.doi.org/10.1155/2020/7380740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306865PMC

Phylogeographical Analyses and Antibiotic Resistance Genes of Highlight Its Clinical Relevance.

mSphere 2020 Jul 1;5(4). Epub 2020 Jul 1.

Laboratorio de Investigación en Agentes Antibacterianos, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulating within single countries; notably, clinical and nonclinical strains are not well differentiated from one another. Importantly, in this species recombination is a significant source of single nucleotide polymorphisms. Read More

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http://dx.doi.org/10.1128/mSphere.00581-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333577PMC

Multidrug Resistance (MDR) and Collateral Sensitivity in Bacteria, with Special Attention to Genetic and Evolutionary Aspects and to the Perspectives of Antimicrobial Peptides-A Review.

Pathogens 2020 Jun 29;9(7). Epub 2020 Jun 29.

Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, H-1581 Budapest, P.O. Box 22, Hungary.

Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are discussed. Arguments for, and against, pessimistic forecasts on a fatal "post-antibiotic era" are evaluated. Read More

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http://dx.doi.org/10.3390/pathogens9070522DOI Listing

Physicochemical, in-vitro therapeutic activity and biomolecular interaction studies of Mn(II), Ni(II) and Cu(II) complexes tethered with ON ligand backbone.

Spectrochim Acta A Mol Biomol Spectrosc 2020 Jun 20;241:118613. Epub 2020 Jun 20.

Centre for Nano and Material Sciences, Jain University, Jain Global Campus, Bengaluru 562112, Karnataka, India. Electronic address:

Two major health crisis of today's world are antimicrobial drug resistance and type II diabetes. To tackle them, there is an immediate requirement for the development of new and safer drugs and the present work is one such quest for novel and efficient drug candidates. We have developed three trace metal coordination compounds tethered with a reduced salen ligand {H(hpdbal)-an} (L), namely, a manganese-salan complex, [Mn(HO){(hpdbal)-an}] (1), a nickel-salan complex, [Ni{(hpdbal)-an}] (2) and a copper-salan complex, [Cu{(hpdbal)-an}] (3). Read More

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http://dx.doi.org/10.1016/j.saa.2020.118613DOI Listing
June 2020
2.353 Impact Factor

[Structural Characteristics of Microbial Communities in the Sediments of the Niyang River in Tibet].

Huan Jing Ke Xue 2020 Jul;41(7):3249-3256

College of Environment, Hohai University, Nanjing 210098, China.

The Niyang River is an important tributary of the Yarlong Zangbo River, which is also an important water source in the Gongbujiangda and Linzhi areas of Tibet. In this study, water and sediment samples from 18 sites in the Niyang River were collected. The physical and chemical properties, concentrations of 12 heavy metals, and the microbial community in the sediments were determined. Read More

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http://dx.doi.org/10.13227/j.hjkx.201912150DOI Listing

[Nitrogen Removal Performance and Nitrogen/Carbon Balance of Oligotrophic Aerobic Denitrifiers].

Huan Jing Ke Xue 2020 May;41(5):2339-2348

Key Laboratory of Northwest Water Resource, Environment and Ecology, Ministry of Education, Xi'an University of Architecture and Technology, Xi'an 710055, China.

Due to the problems of low nitrogen removal efficiency and unclear electron transfer during biological denitrification treatment of an oligotrophic drinking water reservoir, the nitrogen removal characteristics, environmental adaptability, and electron transfer during denitrification were systematically studied using the aerobic denitrifier ZMF5, which has efficient nitrogen removal ability. The results showed that:① Strain ZMF5 exhibited efficient heterotrophic nitrification and aerobic denitrification ability, with an ammonia removal rate of 0.211 mg·(L·h) and a nitrate removal rate of 0. Read More

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http://dx.doi.org/10.13227/j.hjkx.201911201DOI Listing

Recent advances in tackling microbial multidrug resistance with essential oils: combinatorial and nano-based strategies.

Crit Rev Microbiol 2020 Jul 1:1-20. Epub 2020 Jul 1.

Department of Pharmacognosy, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania.

The emergence of multidrug resistant pathogens is a great challenge to the medical field and a major global health threat requiring novel therapeutic strategies. Among plant products, essential oils have significant antimicrobial properties that make them promising agents in the fight against drug resistant human pathogens. The aim of the present review was to highlight the most important essential oil-based antimicrobial strategies as revealed by recent studies. Read More

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http://dx.doi.org/10.1080/1040841X.2020.1782339DOI Listing

Increased Antimicrobial Resistance among Sputum Pathogens from Patients with Hyperglycemia.

Infect Drug Resist 2020 11;13:1723-1733. Epub 2020 Jun 11.

Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: Glucose management is of great significance. Infection and hyperglycemia are a vicious circle. This study was conducted to describe distribution and antimicrobial resistance of bacteria isolated from patients with normoglycemia, hyperglycemia, or diabetes on admission. Read More

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http://dx.doi.org/10.2147/IDR.S243732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295332PMC

Trend and Characteristics of Infections in Patients Attending Universal College of Medical Sciences, Bhairahawa, Western Nepal: A Longitudinal Study of 2018.

Infect Drug Resist 2020 8;13:1631-1641. Epub 2020 Jun 8.

Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Background: is one of the major organisms causing nosocomial infections and is intrinsically resistant to multiple classes of antibiotics. The main objective of this study was to investigate the trend and characteristics of infections including its resistance pattern among patients attending Universal College of Medical Sciences, Teaching Hospital (UCMSTH) in Western Nepal, between January and December 2018.

Patients And Methods: A total of 4862 clinical samples received at the microbiology laboratory of UCMSTH over a period of a year were analyzed. Read More

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http://dx.doi.org/10.2147/IDR.S257851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293404PMC

Gonococcal resistance can be viewed productively as part of a syndemic of antimicrobial resistance: an ecological analysis of 30 European countries.

Antimicrob Resist Infect Control 2020 Jun 30;9(1):97. Epub 2020 Jun 30.

HIV/STI Unit, Institute of Tropical Medicine, 2000, Antwerp, Belgium.

Background: It is unclear how important bystander selection is in the genesis of antimicrobial resistance (AMR) in Neisseria gonorrhoeae.

Methods: We assessed bystander selection in a novel way. Mixed-effects linear regression was used to assess if country-level prevalence of gonococcal AMR in 30 European countries predicts homologous AMR in other bacteria. Read More

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http://dx.doi.org/10.1186/s13756-020-00764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325135PMC

Design and synthesis of 4-[4-formyl-3-(2-naphthyl)pyrazol-1-yl]benzoic acid derivatives as potent growth inhibitors of drug-resistant Staphylococcus aureus.

J Antibiot (Tokyo) 2020 Jun 29. Epub 2020 Jun 29.

Department of Chemistry and Physics, College of Science and Mathematics, Arkansas State University, Jonesboro, AR, 72467, USA.

We report the synthesis and antimicrobial studies of a new series of naphthyl-substituted pyrazole-derived hydrazones. Many of these novel compounds are potent growth inhibitors of several strains of drug-resistant bacteria. These potent compounds have inclined growth inhibitory properties for planktonic Staphylococcus aureus and Acinetobacter baumannii, and its drug-resistant variants with minimum inhibitory concentration (MIC) as low as 0. Read More

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http://dx.doi.org/10.1038/s41429-020-0341-2DOI Listing

Type I pili, CsuA/B and FimA induce a protective immune response against Acinetobacter baumannii.

Vaccine 2020 Jun 27. Epub 2020 Jun 27.

Department of Biology, Shahed University, Tehran Iran; Molecular Microbiology Research Center, Shahed University, Tehran Iran. Electronic address:

Background: Acinetobacter baumannii, a nosocomial pathogen, is considered as a common cause of hospital and community-acquired infections. Emerging multidrug-resistance in this pathogen followed by subsequent problems in treatment has been increasing to alarming levels that warrant investigation of new therapeutic approaches. One strategy to reduce antibiotic resistance is to use of vaccines. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.052DOI Listing

Nosocomial infections due to multidrug-resistant bacteria in cancer patients: a six-year retrospective study of an oncology Center in Western China.

BMC Infect Dis 2020 Jun 29;20(1):452. Epub 2020 Jun 29.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 Yanta West Road, Xi'an, Shaanxi, 710061, People's Republic of China.

Background: Bacterial infections are the most frequent complications in patients with malignancy, and the epidemiology of nosocomial infections among cancer patients has changed over time. This study aimed to evaluate the characteristics, antibiotic resistance patterns, and prognosis of nosocomial infections due to multidrug-resistant (MDR) bacteria in cancer patients.

Methods: This retrospective observational study analyzed cancer patients with nosocomial infections caused by MDR from August 2013 to May 2019. Read More

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http://dx.doi.org/10.1186/s12879-020-05181-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324970PMC

Colistin heteroresistance in Acinetobacter spp; systematic review and meta-analysis of the prevalence and discussion of the mechanisms and potential therapeutic implications.

Int J Antimicrob Agents 2020 Jun 26:106065. Epub 2020 Jun 26.

Internal Medicine Department, General Hospital of Heraklion Venizeleio, Heraklion, Crete, Greece, postal code 71409.

Background: ; Colistin is one of the few remaining options for carbapenem-resistant A. baumannii but emergence of resistance from heteroresistant populations is possible. The aim of this review is to systematically search and consolidate the literature on the prevalence, mechanisms and therapeutic implications of colistin heteroresistance in Acinetobacter spp. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106065DOI Listing

Pandrug-resistant Acinetobacter baumannii treatment: still a debatable topic with no definite solutions.

J Antimicrob Chemother 2020 Jun 29. Epub 2020 Jun 29.

University Hospital of Ioannina, Intensive Care Unit, Stavros Niarchos Avenue, 45500 Ioannina, Greece.

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http://dx.doi.org/10.1093/jac/dkaa264DOI Listing

Gut Microbiota-Based Algorithms in the Prediction of Metachronous Adenoma in Colorectal Cancer Patients Following Surgery.

Front Microbiol 2020 12;11:1106. Epub 2020 Jun 12.

Department of Oncological and Endoscopic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

Evaluating the risk of colorectal metachronous adenoma (MA), which is a precancerous lesion, is necessary for metachronous colorectal cancer (CRC) precaution among CRC patients who had underwent surgical removal of their primary tumor. Here, discovery cohort ( = 41) and validation cohort ( = 45) of CRC patients were prospectively enrolled in this study. Mucosal and fecal samples were used for gut microbiota analysis by sequencing the 16S rRNA genes. Read More

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http://dx.doi.org/10.3389/fmicb.2020.01106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7303296PMC
June 2020
3.941 Impact Factor

Clinical Utilization of Blood and Urine Cultures and Incidences of Bacteremia and Bacteriuria in a Hospital in Thailand.

Med Sci Monit Basic Res 2020 Jun 29;26:e924204. Epub 2020 Jun 29.

Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand.

BACKGROUND To effectively treat sepsis and urinary tract infection (UTI), blood and urine cultures should be used appropriately and relative to incidences of bacteremia and bacteriuria. This study aimed to investigate the use of blood and urine cultures and incidences of bacteremia and bacteriuria in a hospital in Thailand. MATERIAL AND METHODS Medical records of patients admitted from 2016 to 2018 were randomly selected and data in the records were anonymously extracted for investigation. Read More

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http://dx.doi.org/10.12659/MSMBR.924204DOI Listing

Mobilisation of pdif modules in Acinetobacter: a novel mechanism for antibiotic resistance gene shuffling?

Mol Microbiol 2020 Jun 28. Epub 2020 Jun 28.

University of Newcastle, Biological Sciences, School of Environmental and Life Sciences, allaghan, NSW, 2308, Australia.

XerCD-dif site-specific recombination is a well characterised system, found in most bacteria and archaea. Its role is resolution of chromosomal dimers that arise from homologous recombination. Xer-mediated recombination is also used by several plasmids for multimer resolution to enhance stability and by some phage for integration into the chromosome. Read More

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http://dx.doi.org/10.1111/mmi.14563DOI Listing

Healthcare-associated infections in burn patients: Timeline and risk factors.

Burns 2020 May 16. Epub 2020 May 16.

Burn Unit, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

Background: Healthcare-associated infections (HAIs) remain a major challenge in burn research and care. We aimed to describe the epidemiology and timeline of HAIs and to estimate the association of demographics and clinical characteristics with time to HAI among burn patients.

Methods: A prospective cohort study was conducted in a referral burn unit in southwestern Colombia. Read More

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http://dx.doi.org/10.1016/j.burns.2020.04.031DOI Listing

AcGI1, a novel genomic island carrying antibiotic resistance integron In687 in multidrug resistant Achromobacter xylosoxidans in a teaching hospital in Thailand.

FEMS Microbiol Lett 2020 Jun 27. Epub 2020 Jun 27.

Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, UK.

This study investigated the genetic basis of multidrug resistance in two strains of Achromobacter xylosoxidans isolated from patients attending a hospital in Thailand in 2012. These isolates were highly resistant to cephalosporins, aminoglycosides, fluoroquinolones, co-trimoxazole and carbapenems. Whole genome sequencing revealed that the two isolates were not clonally related and identified a carbapenem resistance gene-habouring integron (In687), residing in a novel genomic island, AcGI1. Read More

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http://dx.doi.org/10.1093/femsle/fnaa109DOI Listing

Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli.

J Antimicrob Chemother 2020 Jun 26. Epub 2020 Jun 26.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing 100044, China.

Background: SPR206 is a novel polymyxin analogue. Activity against clinical isolates is little documented.

Methods: A collection of 200 MDR, carbapenem-resistant, tigecycline-resistant, colistin-resistant and non-MDR clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Enterobacter cloacae and Stenotrophomonas maltophilia was obtained from 50 centres across China (2016-17). Read More

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http://dx.doi.org/10.1093/jac/dkaa217DOI Listing

Primary and secondary succession mediates the accumulation of biogenic amines during industrial semidry Chinese rice wine fermentation.

Appl Environ Microbiol 2020 Jun 26. Epub 2020 Jun 26.

The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, P. R. China.

The exogenous functional microorganisms to regulate the biogenic amines (BAs) content is a common approach in fermentation systems. Here, to better understand the microbial traits of succession trajectories in resource-based and biotic interference system, the BAs-related primary and secondary succession were tracked during industrial semidry Chinese rice wine (CRW) fermentation. Dominant abundance and BAs-associated microbial functionality based on PICRUSt indicated that , , and were prominently contributed to decarboxylase gene family in CRW. Read More

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http://dx.doi.org/10.1128/AEM.01177-20DOI Listing