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Bioorg Chem 2019 Apr 16;88:102931. Epub 2019 Apr 16.

Department of Chemistry, Faculty of Science, Atatürk University, 25240-Erzurum, Turkey.

Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods. in vitro antibacterial susceptibility of Acinetobacter baumannii, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus strains to synthesized substances were evaluated with agar well-diffusion method by comparison with commercially available drugs. Most of the bacteria were multidrug resistant. Read More

Leuk Lymphoma 2019 Apr 24:1-6. Epub 2019 Apr 24.

b Sackler School of Medicine , Tel-Aviv University , Tel-Aviv , Israel.

Carbapenem resistant Acinetobacter baumannii (CRAB) is a significant cause of hospital acquired bloodstream infections in patients with hematological malignancies. Data regarding outcomes in this group of patients are limited. We retrospectively analyzed mortality risk factors of hospitalized hematological patients with CRAB bacteremia in our center. Read More

Antibiotics (Basel) 2019 Apr 12;8(2). Epub 2019 Apr 12.

Department of Internal Medicine; Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

The manuscripts contained in this special edition of Antibiotics represent a current review of the polymyxins as well as highlights from the 3rd International Polymyxin Conference, which was held in Madrid, Spain, April 25 to 26, 2018. The role of the polymyxin antibiotics has evolved over time based on the availability of alternative agents. After high rates of nephrotoxicity caused the drug class to fall out of favor, polymyxins were once against utilized in the 21st century to combat drug-resistant pathogens. Read More

Iran J Pharm Res 2018 ;17(Suppl2):206-213

Department of Clinical Pharmacy, school of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Due to the emerging antibiotic resistance of Acinetobacter, which is the leading cause of ventilator-associated pneumonia (VAP) in critically ill patients, there is an urgent need for studies comparing various antibiotic regimens for its treatment. In this single blinded randomized clinical trial, adult patients with VAP due to multi drug resistant Acinetobacter (MDRA), were randomly assigned to receive 9×10 unit loading dose of colistin followed by 4.5×10 unit intravenously twice daily plus 750 mg intravenous levofloxacin daily or continuous infusion of ampicillin/sulbactam, 24g daily plus 750mg IV levofloxacin daily. Read More

J Interferon Cytokine Res 2019 Apr 23. Epub 2019 Apr 23.

Department of Pathology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey.

is an emerging opportunistic pathogen that has risen to become a serious global threat, prevalent in health care settings and the community, which results in high morbidity and mortality rates. Its alarming expansion of antibiotic resistance is one of the most problematic traits of and as so, this bacterium has been classified as a serious threat and high priority target by the CDC. The most common types of infections induced by this pathogen include pneumonia (both hospital and community acquired), bacteremia, skin and soft tissue, urinary tract infections, endocarditis, and meningitis. Read More

Crit Rev Microbiol 2019 Apr 23:1-19. Epub 2019 Apr 23.

a Department of Biotechnology , Dayananda Sagar College of Engineering , Bangalore , India.

Acinetobacter baumannii (AB) is one of the most notorious and opportunistic pathogens, which caused high morbidity and mortality rate and World Health Organization (WHO) declared this bacterium as priority-1 pathogen in 2017. The current antibacterial agents, such as colistins, carbapenems, and tigecyclines have limited applications, which necessitate novel and alternative therapeutic remedies. Thus, the understanding of recent perspectives on the virulent factors and antibiotic resistance mechanism exhibited by the bacteria are extremely important. Read More

Antimicrob Agents Chemother 2019 Apr 22. Epub 2019 Apr 22.

JMI Laboratories, North Liberty, Iowa, USA.

Bloodstream infection (BSI) organisms were consecutively collected from >200 medical centers in 45 nations between 1997 and 2016. Species identification and susceptibility testing followed Clinical and Laboratory Standards Institute broth microdilution methods at a central laboratory. Clinical data and isolates from 264,901 BSI episodes were collected. Read More

Microb Drug Resist 2019 Apr 22. Epub 2019 Apr 22.

Presented in part at ID Week 2016, New Orleans, Louisiana.

Multidrug-resistant (MDR) is a difficult pathogen due to its propensity to develop resistance to antibiotics. Antisense nucleic acid analogs have been proposed as a potential alternative anti-infective approach. We developed a peptide nucleic acid (PNA) compound that targets the essential gene . Read More

J Laryngol Otol 2019 Apr 22:1-5. Epub 2019 Apr 22.

Advanced Head and Neck Oncology and Microvascular Reconstruction, Thyroid and Parathyroid Surgery, Foothills Medical Centre, Faculty of Medicine; Department of Surgery, Section of Otolaryngology-Head and Neck Surgery,University of Calgary,Calgary, Alberta,Canada.

Background: Medical equipment can transmit pathogenic bacteria to patients. This single-institution point prevalence study aimed to characterise the types and relative amount of bacteria found on surgical loupes, headlights and their battery packs.

Method: Surgical loupes, headlights and battery packs of 16 otolaryngology staff and residents were sampled, cultured and quantified. Read More

Scand J Immunol 2019 Apr 21:e12769. Epub 2019 Apr 21.

Institute of Immunology and Molecular Biology, North Sichuan Medical College, Nanchong, 637000, People's Republic of China.

Acinetobacter baumannii (A. baumannii) is an emerging nosocomial pathogenic bacterium which leads to hospital infections. The increase of drug-resistant A. Read More

Sci Rep 2019 Apr 19;9(1):6300. Epub 2019 Apr 19.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Despite strengthened antimicrobial therapy, biofilm infections of Acinetobacter baumannii are associated with poor prognosis and limited therapeutic options. Assessing antibiotics on planktonic bacteria can result in failure against biofilm infections. Currently, antibiotics to treat biofilm infections are administered empirically, usually without considering the susceptibility of the biofilm objectively before beginning treatment. Read More

J Infect Chemother 2019 Apr 16. Epub 2019 Apr 16.

Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Microbiology, Fujita Health University, Aichi, Japan.

Post-surgical intra-abdominal infections (IAIs) due to carbapenem-resistant Acinetobacter baumannii (CRAB) are difficult to treat due to suboptimal peritoneal penetrations of several antimicrobial agents. Tigecycline has favorable outcomes of treating IAIs due to multidrug-resistant organisms but occurrence of breakthrough bacteremia has been observed because this agent has low serum level. Colistin has in vitro activity against CRAB but data on treatment of IAIs is limited due to poor peritoneal penetration. Read More

Am J Infect Control 2019 Apr 16. Epub 2019 Apr 16.

Department of Respiratory Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) tops the list of threats to human health. Studies exploring predictors of mortality in patients with CRAB infection produced conflicting results.

Methods: A systematic search of the PubMed, Embase, and the Cochrane Library databases was performed from inception to June 2018 to identify studies reporting mortality predictors in patients infected with CRAB. Read More

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Laboratory of Molecular Biology, Genomics and Bioinformatics, Faculty of Nature and Life Science, Hassiba Benbouali University, Chlef, Hay Essalam, 02000, Algeria.

A new exopolysaccharide (EPS) was produced by the Lactococcus lactis F-mou strain (LT898177.1) isolated from the Sahrawi camel milk in the Bir-Naam region, Algeria. The most influential production parameters were screened by the Plackett-Burman design for enhancing EPS yield utilizing the Mech-Degla juice as a low-cost raw material. Read More

ACS Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

In 2016, the World Health Organization deemed antibiotic resistance one of the biggest threats to global health, food security, and development. The need for new methods to combat infections caused by antibiotic resistant pathogens will require a variety of approaches to identifying effective new therapeutic strategies. One approach is the identification of small molecule adjuvants that potentiate the activity of antibiotics of demonstrated utility, whose efficacy is abated by resistance, both acquired and intrinsic. Read More

Sci Rep 2019 Apr 18;9(1):6266. Epub 2019 Apr 18.

Antimicrobial Research Unit, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. The aim of this study was to characterize ESBL-producing K. pneumoniae detected within and between two hospitals in uMgungundlovu district, South Africa, using whole genome sequencing (WGS). Read More

J Infect Public Health 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesia, Lady Hardinge Medical College, New Delhi, India.

Background: Throughout the world multi drug resistant nosocomial infections are one of the leading causes of death and morbidity among hospitalized patients. Antimicrobial resistance [AMR] has become a major problem in treatment of such infections. High consumption of antimicrobials particularly in ICUs is often described as the most important factor leading to AMR. Read More

Food Res Int 2019 Jun 14;120:668-678. Epub 2018 Nov 14.

Chinese Academy of Inspection and Quarantine, No.11, Ronghua South Street, Daxing District, Beijing 100176, China. Electronic address:

Prepared foods have received increasing attention owing to their convenience, rapidness, and ease of processing in a fast-paced life. The bacterial diversity and composition vary among different prepared foods and are closely related to food safety and human health. However, the knowledge on the bacterial community in prepared foods is still limited. Read More

Microb Drug Resist 2019 Apr 17. Epub 2019 Apr 17.

2 Department of Medical, Oral and Biotechnological Sciences, and Center of Excellence on Aging and Translational Medicine (CeSI-MeT), "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

The main goal of this study was to identify Gram-negative bacteria resistant to antibiotics, in particular β-lactams, in stream waters and effluents from urban wastewater treatment plants draining into Fino, Tavo, and Saline rivers of the Abruzzo region, Italy. Eight sampling sites were selected because they were the most contaminated by coliforms during previous sampling campaign. One sample for each site was collected for the detection of total and fecal coliforms, and species by Colilert-18 and Enterolert-E Quanti-Tray/2000. Read More

J Infect Public Health 2019 Apr 13. Epub 2019 Apr 13.

Research Center, King Fahad Medical City, Riyadh, Saudi Arabia. Electronic address:

Aim: To identify the risk factors, laboratory profile, microbial profile, mortality and complications, mortality causing organisms and antimicrobial susceptibility patterns of neonatal sepsis at a tertiary care hospital.

Methods: A retrospective study was conducted using the neonatal intensive care unit (NICU) database in King Fahad Medical City (KFMC), Riyadh, Saudi Arabia. All neonates born in KFMC with clinically diagnosed sepsis in the NICU were included in this study. Read More

Nat Prod Res 2019 Apr 16:1-5. Epub 2019 Apr 16.

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering , Lanzhou University , Lanzhou , People's Republic of China.

A new isopimarane-type diterpenoid, crolaevinoid A, along with four known analogues was isolated from the twigs and leaves of Croton laevigatus. The structures of the isolated compounds were established on the basis of NMR and MS spectroscopic analyses. The isolated compounds were examined the antibacterial activities. Read More

Zhongguo Zhong Yao Za Zhi 2019 Mar;44(6):1145-1150

College of Biological and Pharmaceutical Engineering,West Anhui University Lu'an 237012,China Anhui Province Traditional Chinese Medicine Resource Protection and Sustainable Utilization Engineering Laboratory Lu'an 237012,China.

In order to explore endophytes diversity and difference in Dendrobium huoshanense,in this paper,the metagenomics method was used to analyze the endophytic bacteria and fungi community of 5 groups include 30 samples in different growth years. The results indicate that 3 540 bacterial OTUs were identified from D. huoshanense,and there are 138 OTUs in 5 groups simultaneously;2 168 fungal OTUs were identified,and 143 OTUs exist in 5 groups simultaneously. Read More

Mol Biol Rep 2019 Apr 12. Epub 2019 Apr 12.

Infectious Disease Unit, 3rd Department of Pediatrics, Medical Faculty, Aristotle University School of Health Sciences, Hippokration General Hospital, Konstantinoupoleos 49, 546 42, Thessaloniki, Greece.

We report a predominance (64.7%) of polyclonal carbapenem-resistant Acinetobacter baumannii (CRAB) strains concurrently producing OXA-23 and OXA-58 carbapenemases in a pediatric intensive care unit in an endemic area. This is the first report of emergence of such double-OXA CRAB strains in a single unit worldwide. Read More

Curr Microbiol 2019 Apr 15. Epub 2019 Apr 15.

Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.

Successful clones of Acinetobacter baumannii cause a variety of nosocomial infections through serum resistance, biofilm formation, and antimicrobial resistance as virulence capabilities. Fifty clinical isolates of multidrug-resistant (MDR) A. baumannii were analyzed for clonal relatedness, serum resistance, biofilm formation, and in vivo assays. Read More

Int J Crit Illn Inj Sci 2019 Jan-Mar;9(1):16-20

Department of Anaesthesiology and Critical Care, Smt. Kashibai Navale Medical College, Pune, Maharashtra, India.

Aims: This study aims to study the incidence, microbiological and antibiotic sensitivity and resistance profile and impact on intensive care units (ICUs) stay and mortality of nosocomial infections in patients admitted to surgical ICU of our hospital.

Methods: A retrospective analysis of all patients admitted, over the course of 1 year, in the surgical ICU was undertaken. All patients who developed nosocomial infections were included in the study. Read More

Front Microbiol 2019 1;10:539. Epub 2019 Apr 1.

Department of Microbiology, Savitribai Phule Pune University, Pune, India.

The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance and virulence: , and spp. Persistent use of antibiotics has provoked the emergence of multidrug resistant (MDR) and extensively drug resistant (XDR) bacteria, which render even the most effective drugs ineffective. Extended spectrum β-lactamase (ESBL) and carbapenemase producing Gram negative bacteria have emerged as an important therapeutic challenge. Read More

Plants (Basel) 2019 Apr 4;8(4). Epub 2019 Apr 4.

Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore 54590, Pakistan.

The main objective of this study was to evaluate the genetic diversity and agricultural significance of bacterial communities associated with the surfaces of selected agronomic plants (carrot, cabbage and turnip). The bacterial diversity of fresh agricultural produce was targeted to identify beneficial plant microflora or opportunistic human pathogens that may be associated with the surfaces of plants. Bacterial strains were screened in vitro for auxin production, biofilm formation and antibiotic resistance. Read More

J Hosp Infect 2019 Apr 12. Epub 2019 Apr 12.

Department of Immunology, Microbiology and Parasitology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU) Leioa, Spain; Research Centre for Experimental Marine Biology and Biotechnology (PIE-UPV/EHU), Plentzia, Spain.

Background: While being a cause of healthcare-associated infections, Acinetobacter baumannii possesses considerable potential to survive on inanimate hospital surfaces under hostile conditions (e.g. disinfection or desiccation). Read More

PLoS One 2019 15;14(4):e0215177. Epub 2019 Apr 15.

Department of Medical Microbiology, School of Biomedical and laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Infections caused by extended-spectrum beta-lactamases (ESBL) producing Gram-negative bacteria has emerge as a global threat in clinical practices. The treat is more serious in developing countries due to inappropriate use, poor adherence, use of counterfeit, sub-standard antibiotics and poor infection control practices. Data on ESBL producing Gram-negative bacteria are limited in developing countries including Ethiopia. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15139

Department of Infectious Disease.

Rationale: The treatment of intracranial Acinetobacter baumannii infections is made difficult by multidrug-resistance poor drug penetration through the blood-brain barrier (BBB). Although tigecycline appears to be effective against A baumannii, it is only administered intravenously because it does not readily cross the BBB. The addition of intraventricular (IVT) or intrathecal infusions of tigecycline could revolutionize clinical therapy for intracranial A baumannii infections. Read More

Front Microbiol 2019 29;10:632. Epub 2019 Mar 29.

Laboratory of Molecular Genetics of Microorganisms, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia.

The /Xer system of site-specific recombination allows resolution of chromosomal dimers during bacterial DNA replication. Recently, it was also shown to be involved in horizontal transfer of a few known Xer-dependent mobile elements. Here, we show that plasmids of various species, including clinically important strains, often contain multiple p sites that are mainly located within their accessory regions. Read More

J Lab Physicians 2019 Jan-Mar;11(1):58-62

Department of Surgery, Government Medical College and Hospital, Chandigarh, India.

Aims: Diabetic foot ulcer is a dreaded complication of diabetes. Diabetic foot ulcer patients are often infected with multidrug resistant organism (MDRO) due to chronic course of the wound, inappropriate antibiotics treatment, frequent hospital admission, neuropathy, nephropathy, and peripheral vascular disease.

Materials And Methods: This prospective study was conducted in our 750 bedded hospital for a period of 6 months. Read More

J Lab Physicians 2019 Jan-Mar;11(1):34-38

Department of Laboratory Medicine, JPNATC, AIIMS, New Delhi, India.

Introduction: spp. has emerged as a major cause of nosocomial outbreaks. Multiple antibiotic resistance is an important problem in isolates in recent years. Read More

J Lab Physicians 2019 Jan-Mar;11(1):23-28

Department of Microbiology, Government Medical College, Srinagar, Jammu and Kashmir, India.

Background: species are typical nosocomial pathogens causing infections and high mortality, almost exclusively in compromised hospitalized patients. sp. are intrinsically less susceptible to antibiotics and have propensity to acquire resistance. Read More

J Chemother 2019 Apr 14:1-6. Epub 2019 Apr 14.

d Intensive Care Unit , King Saud Medical City , Riyadh , Saudi Arabia.

We conducted a two-phase retrospective study to investigate the impact of a short-term carbapenem restriction on the incidence of non-pseudomonal multidrug-resistant (MDR) Gram-negative bacilli in our intensive care unit (ICU). The first phase of the study (before carbapenem restriction) was conducted between May and July 2016, and the second phase (implementation of carbapenem restriction) between September and November 2016. The incidence of all non-pseudomonal MDR Gram-negative bacilli (extended-spectrum β-lactamase-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae and MDR Acinetobacter baumannii) decreased significantly after carbapenem restriction. Read More

Plasmid 2019 Apr 11;103:36-44. Epub 2019 Apr 11.

School of Life and Environmental Sciences, The University of Sydney, NSW 2006, Australia. Electronic address:

Most Acinetobacter plasmids are genus specific but their properties have not been investigated. Small plasmids with Rep_3 family replication initiation proteins and iterons are common in Acinetobacter baumannii and often carry antibiotic resistance genes and toxin-antitoxin systems. A RepAci1 plasmid, carrying the carbapenem resistance gene oxa23 in Tn2006 and a RepAci2 plasmid carrying the amikacin (kanamycin and neomycin) resistance gene aphA6 in TnaphA6 were identified. Read More

Bioresour Technol 2019 Jul 25;284:456-465. Epub 2019 Mar 25.

School of Energy Science and Engineering, Central South University, Changsha 410083, PR China.

It was found in this study that the presence of sophorolipid (SL) enhanced the production of short-chain fatty acid (SCFA) from anaerobic fermentation of waste activated sludge (WAS). Experimental results showed that with an increase of SL addition from 0 to 0.1 g/g TSS, the maximal SCFA yield increased from 50. Read More

J Glob Antimicrob Resist 2019 Apr 10. Epub 2019 Apr 10.

Centre for cellular and Molecular Biology, Uppal Road, Habsiguda, Hyderabad, Telangana 500007, India.

Microb Pathog 2019 Apr 10;131:186-196. Epub 2019 Apr 10.

Department of Microbiology and Immunology, University of Belgrade, Faculty of Pharmacy, Vojvode Stepe 450, 11221, Belgrade, Serbia. Electronic address:

Acinetobacter baumannii and Pseudomonas aeruginosa are frequent multiresistant nosocomial pathogens that cause wound and pulmonary infections in hospitalized patients. As being increasingly resistant to most clinically available antibiotics, there is a constant need for exploration of new substances that could kill them or inhibit their growth, or alternatively inhibit some of their essential virulence factors. Chalcones are chemical compounds with well-documented antimicrobial potential. Read More

Transfusion 2019 Apr;59(S2):1479-1489

U.S. Army Institute of Surgical Research, Coagulation and Blood Research Task Area, Texas.

Introduction: Due to high risk of septic transfusion reactions arising from bacterial contamination, US Food and Drug Administration regulations currently limit platelet storage to 5 days at room temperature (RT). However, blood culturing methods can take up to 7 days to detect bacteria, allowing transfusion of potentially contaminated units. Thus, cold storage (CS) may be a viable means of extending shelf life and improving safety. Read More

New Microbes New Infect 2019 May 8;29:100526. Epub 2019 Mar 8.

Facultad de Ciencias Químicas, Universidad Central del Ecuador, Quito, Pichincha, Ecuador.

Objectives: To describe a clinical case of sequence type (ST) 32 harbouring a New Delhi metallo-β-lactamase (NDM) in Ecuador.

Methods: We used multilocus sequence typing (MLST) to confirm the bacterial species and the sequence type of an isolate. We used synergy with the imipenem-EDTA disc method and the carbapenem inactivation method (CIM) to determine carbapenemase production; the presence of a carbapenemase gene was confirmed by PCR amplification and amplicon sequencing. Read More

Antimicrob Resist Infect Control 2019 29;8:61. Epub 2019 Mar 29.

1Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, No.1, Youyi Road, Yuzhong District, Chongqing, 400016 People's Republic of China.

Background: ESKAPEEc contribute to a majority of bloodstream infections (BSIs) and their antibiogram have changed overtime, while data concerning about these alterations are lacking in China. Added that a paucity of studies referred to ESKAPEEc in pediatric BSIs, our study aimed to demonstrate the longitudinal alterations of ESKAPEEc distribution and antibiogram in adult and pediatric BSIs in Southwest China.

Methods: A multicenter retrospective surveillance study was launched from 2012 to 2017. Read More

Int J Mol Sci 2019 Apr 10;20(7). Epub 2019 Apr 10.

Department of Oral Biology, Rady Faculty of Health Sciences, University of Manitoba, 780 Bannatyne Ave, Winnipeg, MB R3E 0J9, Canada.

Gram-negative pathogens such as , , and are the leading cause of nosocomial infections throughout the world. One commonality shared among these pathogens is their ubiquitous presence, robust host-colonization and most importantly, resistance to antibiotics. A significant number of two-component systems (TCSs) exist in these pathogens, which are involved in regulation of gene expression in response to environmental signals such as antibiotic exposure. Read More

Antibiotics (Basel) 2019 Apr 10;8(2). Epub 2019 Apr 10.

Medicine Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA.

Polymyxins have been a mainstay for the treatment of extensively drug resistant (XDR) Gram-negative bacteria for the past two decades. Many questions regarding the clinical use of polymyxins have been answered, but whether the administration of polymyxins in combination with other antibiotics leads to better outcomes remains unknown. This review discusses the limitations of observational studies that suggest a benefit of combinations of colistin and carbapenems to treat infections caused by carbapenem-resistant Enterobacteriaceae (CRE), especially carbapenemase (KPC)-producing , and summarizes the results of randomized controlled trials in which treatment with colistin in combination with meropenem or rifampin does not lead to better clinical outcomes than colisitn monotherapy in infections caused by carbapenem-resistant (CRAB). Read More

Toxins (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Laboratory of Immunopathology of infectious diseases, Department of Immunology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, Rua 235, Goiania, 74605-050 Goiás, Brazil.

Intravascular stent infection is a rare complication with a high morbidity and high mortality; bacteria from the hospital environment form biofilms and are often multidrug-resistant (MDR). Antimicrobial peptides (AMPs) have been considered as alternatives to bacterial infection treatment. We analyzed the formation of the bacterial biofilm on the vascular stents and also tested the inhibition of this biofilm by AMPs to be used as treatment or coating. Read More

Drugs 2019 Apr 10. Epub 2019 Apr 10.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, 100, Taiwan.

A gradual rise in drug-resistant trends among Gram-negative organisms, especially carbapenem-resistant (CR) Enterobacteriaceae (CRE), CR-Pseudomonas aeruginosa, and extensively-drug-resistant (XDR) Acinetobacter baumannii, poses an enormous threat to healthcare systems worldwide. In the last decade, many pharmaceutical companies have devoted enormous resources to the development of new potent antibiotics against XDR Gram-negative pathogens, particularly CRE. Some of these novel antibiotics against CRE strains are β-lactam/β-lactamase-inhibitor combination agents, while others belong to the non-β-lactam class. Read More

Front Microbiol 2019 26;10:559. Epub 2019 Mar 26.

Department of Laboratory Medicine, Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea.

spp. have emerged as significant pathogens causing nosocomial infections. Treatment of these pathogens has become a major challenge to clinicians worldwide, due to their increasing tendency to antibiotic resistance. Read More

Clin Lab 2019 Apr;65(4)

Background: Acinetobacter baumannii (Ab) is an important opportunistic pathogen in a hospital setting. The virulence varies among different clinical isolates, which can be measured by cytotoxicity assay or Galleria mellonella killing assay. However, these measurements are not suitable for routine clinical laboratory application. Read More

Biomater Sci 2019 Apr 10. Epub 2019 Apr 10.

College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.

Multiple drug resistance and the increase in the appearance of superbugs together with the exceedingly scant development of new potent antibiotic drugs pose an urgent global medical threat and imminent public security crisis. In the present study, we fabricated well-dispersed tocopherol polyethylene glycol succinate (TPGS)-capped silver nanoparticles (AgNPs) of about 10 nm in size. The hollow structure of the TPGS-capped AgNPs (TPGS/AgNPs) was confirmed and applied to load antibiotics. Read More

Front Microbiol 2019 22;10:593. Epub 2019 Mar 22.

Laboratorio de Referencia e Investigación en Taxonomía, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.

Our objective was to improve current knowledge of sporadic (Spo) nosocomial (Acb) complex populations, and thus better understand the epidemiology of Spo and endemoepidemic (EE) strains. Between 1999 and 2010, 133 isolates of Spo Acb complex were obtained from a single hospital. Species were identified by B-PCR, and via B- and B-sequencing. Read More