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Arch Microbiol 2022 Jun 24;204(7):422. Epub 2022 Jun 24.

Nitte (Deemed to Be University), Nitte University Centre for Science Education and Research, Paneer Campus, Deralakatte, Mangaluru, Karnataka, 575018, India.

Over the last decade, Acinetobacter baumannii has emerged as one of the main causes of infections acquired in the hospital setting. Outbreaks associated with this pathogen are caused mainly due to contamination and transmission in hospital territories. However, the natural habitats of A. Read More

Bioresour Technol 2022 Jun 21:127506. Epub 2022 Jun 21.

School of Chemistry and Chemical Engineering, Chongqing University of Technology, Chongqing 40054, China. Electronic address:

To enhance the performance of moving bed biofilm reactor (MBBR) inoculated with heterotrophic nitrification-aerobic denitrification (HN-AD) bacteria, bioaugmentation with Acinetobacter sp. TAC-1 was firstly employed and then the treatment performance for real swine wastewater was presented in this study. Results indicated that NH-N and TN removal rates of bioaugmented reactor were significantly improved from 16. Read More

Talanta 2022 Jun 16;249:123696. Epub 2022 Jun 16.

Biomedical Device Technology Program, Vocational School of Health Services, Izmir Democracy University, Izmir 35140, Turkey; Department of Analytical Chemistry, Faculty of Pharmacy, Ege University, Izmir 35100, Turkey. Electronic address:

A new genosensor, which allows sensitive and selective detection of Acinetobacter baumannii gene sequence was developed herein. In this assay, capture probe of Acinetobacter baumannii was immobilized on the surface of chitosan modified single-use pencil graphite electrodes (c-PGEs) to obtain Acinetobacter baumannii genosensor. Then, Acinetobacter baumannii target DNA sequence was recognized after solid-state hybridization on c-PGE genosensor by measuring guanine signal via differential pulse voltammetry (DPV). Read More

Nat Prod Res 2022 Jun 24:1-9. Epub 2022 Jun 24.

Department of Chemistry, University of Education, Ho Chi Minh City, Vietnam.

is a tropical plant that is widely used in folk medicine. Little is known about the chemical constituents of flowers of this plant. From flowers of the native plant in Vietnam, 12 compounds were isolated and elucidated, including one new compound tecomastane () and eleven known compounds, (3,5,6,7)-5,6-epoxy-3-hydroxy-7-megastigmane-9-one (), bosciallin (), chakyunglupulin B (), (2,6)-2,6-dimethyloctane-1,8-diol (), cleroindicin F (), rengyoxide (), 3,4-dihydroxybenzoic acid (), methyl 3,4-dihydrobenzoate (), 3,5-dihydroxybenzoic acid (), luteolin (), and indole-3-carboxylic acid (). Read More

Anal Chem 2022 Jun 24. Epub 2022 Jun 24.

Key Laboratory of Luminescence Analysis and Molecular Sensing (Ministry of Education), College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

As a multidrug-resistant pathogen, has long been identified as one of the most common nosocomial bacteria. High-performance recognition probes for wide-spectrum detection of are highly desired to achieve efficient diagnosis and timely treatment of infectious diseases induced by this pathogen. An engineering tail fiber protein (ETFP) named as Gp50 encoded by lytic phage Abp9 was expressed in and identified as a binding protein for . Read More

Arch Microbiol 2022 Jun 24;204(7):421. Epub 2022 Jun 24.

Chair of Microbiology, Department of Laboratory Medicine, Immunology and Laboratory Medicine, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, 70-111, Szczecin, Poland.

The growing interest in bacteriophages and antibiotics' combined use poses new challenges regarding this phenomenon's accurate description. This study aimed to apply the PhageScore methodology to assess the phage-antibiotic combination activity in liquid bacterial culture. For this purpose, previously described Acinetobacter infecting phages vB_AbaP_AGC01, Aba-1, and Aba-4 and antibiotics (gentamicin, ciprofloxacin, meropenem, norfloxacin, and fosfomycin) were used to obtain a lysis curve of bacteriophages under antibiotic pressure. Read More

Front Microbiol 2022 7;13:911777. Epub 2022 Jun 7.

Department of Medical Microbiology, School of Biology and Basic Medical Science, Medical College of Soochow University, Suzhou, China.

Red swamp crayfish () have become one of the favorite aquatic products in China. The modern farming mode which uses antibiotics to prevent diseases could impact the bacteria in crayfish intestines. Here, we determined the distribution and antimicrobial resistance phenotypes of the selected culturable bacteria in crayfish intestines and characterized an isolate with last-line antibiotic resistance determinant. Read More

Viruses 2022 Jun 7;14(6). Epub 2022 Jun 7.

Institute of Medical Sciences, Tzu Chi University, No. 701, Sec. 3, Zhongyang Rd., Hualien 97004, Taiwan.

Multidrug-resistant (MDRAB) is a pathogen recognized as antimicrobial-resistant bacteria involved in healthcare-associated infections. Resistance to antibiotics has made alternative therapies necessary. Bacteriophage therapy is considered a potential solution to treat MDRAB. Read More

Pharmaceutics 2022 Jun 14;14(6). Epub 2022 Jun 14.

Epidemiology Research Group of Infectious Disease (ERGID), Chiang Mai University, Chiang Mai 50200, Thailand.

Carbapenem-resistant   (CRAB) is becoming more widely recognized as a serious cause of nosocomial infections, and colistin has been reintroduced in recent years for the treatment of CRAB infection. Combinations of colistin and meropenem or imipenem have been found to be effective against CRAB isolates, whereas clinical investigations have not definitively demonstrated the theoretical benefits of colistin combined therapy in patients with CRAB infections. The objective of this study was to compare the primary outcome (30-day survival rate) and secondary outcomes (clinical response, microbiological response and nephrotoxicity) between patients who received loading dose (LD) colistin-meropenem and LD colistin-imipenem for the treatment of CRAB infection. Read More

Pharmaceutics 2022 May 31;14(6). Epub 2022 May 31.

Saint-Petersburg Pasteur Institute, Street Mira, 14, 197101 St. Petersburg, Russia.

Bacterial infections have accompanied humanity throughout its history and became vitally important in the pandemic area. The most pathogenic bacteria are multidrug-resistant strains, which have become widespread due to their natural biological response to the use of antibiotics, including uncontrolled use. The current challenge is finding highly effective antibacterial agents of natural origin, which, however, have low solubility and consequently poor bioavailability. Read More

Pathogens 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Human Pathology, University of Messina, 98125 Messina, Italy.

Infections caused by bacteria have a major impact on public health-related morbidity and mortality. Despite major advances in the prevention and treatment of bacterial infections, the latter continue to represent a significant economic and social burden worldwide. The WHO compiled a list of six highly virulent multidrug-resistant bacteria named ESKAPE (, , , , , and species) responsible for life-threatening diseases. Read More

Microorganisms 2022 Jun 15;10(6). Epub 2022 Jun 15.

Department of Bacteriology, Microbial Ecology and Parasitology, Chair of Microbiology, Jagiellonian University Medical College, 31-121 Cracow, Poland.

Many difficult-to-treat human infections related to catheters and other indwelling devices are caused by bacteria residing in biofilms. One of the key properties of microorganisms residing in a biofilm is decreased susceptibility towards antimicrobial agents. Therefore, many different approaches have been researched to destroy or inhibit biofilm production by bacteria. Read More

Microorganisms 2022 Jun 11;10(6). Epub 2022 Jun 11.

Department of Plant Sciences, North Dakota State University, Fargo, ND 58102, USA.

Histamine is a toxic biogenic amine commonly found in seafood products or their derivatives. This metabolite is produced by histamine-producing bacteria (HPB) such as , , , , , , , , spp., , , , , , , , , , spp. Read More

Microorganisms 2022 Jun 2;10(6). Epub 2022 Jun 2.

Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

The effects of organic fertilizer application on the soil microbial community in grassland systems have been extensively studied. However, the effects of organic fertilizers on the structure of rhizosphere microbial communities are still limited. In this study, the diversity and composition of rhizosphere microbial communities of a gramineous grass under organic fertilizer treatment were studied in an artificial pasture on Qinghai-Tibet Plateau. Read More

J Clin Med 2022 Jun 7;11(12). Epub 2022 Jun 7.

Head, Infection Prevention and Control-Infectious Disease Service, Foundation University Hospital Campus Bio-Medico, 00128 Rome, Italy.

is a frequent cause of difficult-to-treat healthcare-associated infections. The use of a novel beta-lactamase inhibitor, durlobactam, has been proposed against multidrug-resistant . A systematic review of studies assessing the efficacy and safety of durlobactam in the treatment of multidrug-resistant infections was carried out. Read More

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Almazov National Medical Research Centre, 197341 Saint Petersburg, Russia.

Metformin is a first-line drug for DM2 treatment and prevention, but its complex effect on impaired glucose tolerance (IGT), including its influence on myocardial resistance to ischemia-reperfusion injury, is not completely studied. We aimed to evaluate the influence of metformin on the intestinal microbiota (IM), metabolism, and functional and morphological characteristics of myocardium in rats with IGT. IGT was modelled in SPF Wistar rats with a high-fat diet and streptozotocin and nicotinamide injection. Read More

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Laboratorio de Investigación Clínica y Ambiental, Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación de Carpio y Plan de Ayala s/n, Col. Casco de Santo Tomas, Miguel Hidalgo, Ciudad de Mexico 11340, Mexico.

is a Gram-negative bacillus that causes multiple infections that can become severe, mainly in hospitalized patients. Its high ability to persist on abiotic surfaces and to resist stressors, together with its high genomic plasticity, make it a remarkable pathogen. Currently, the isolation of strains with high antimicrobial resistance profiles has gained relevance, which complicates patient treatment and prognosis. Read More

Diagnostics (Basel) 2022 Jun 17;12(6). Epub 2022 Jun 17.

Department of Laboratory Medicine, Ewha Womans University College of Medicine, Seoul 07985, Korea.

Performances of the colistin antimicrobial susceptibility testing (AST) systems of vary depending on the manufacturer, and data on colistin-resistant are limited. We evaluated the VITEK2 and Sensititre systems to determine colistin resistance and minimum inhibitory concentration (MIC) for isolated from a clinical microbiology laboratory. A total of 213 clinical isolates were tested, including 81 colistin-resistant . Read More

Antibiotics (Basel) 2022 Jun 20;11(6). Epub 2022 Jun 20.

Clinic of Infectious Diseases, Department of Infectious Diseases, University of Modena, 41124 Modena, Italy.

The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application of antimicrobial stewardship (AS) models and infection prevention and control (IPC) programs. We aimed to evaluate the impact of COVID-19 on antimicrobial consumption (AC) and antimicrobial resistance (AMR) in the University Hospital of Modena. A time series analysis with an autoregressive integrated moving average model was conducted from January 2015 to October 2021 to evaluate the AC in the whole hospital and the intensive care unit (ICU), the incidence density (ID) of bloodstream infections (BSIs) due to the main multidrug-resistant organisms, and of infections (CDIs). Read More

Antibiotics (Basel) 2022 Jun 14;11(6). Epub 2022 Jun 14.

Key Laboratory of Clinical Pharmacology of Antibiotics, National Population and Family Planning Commission, Shanghai 200040, China.

Colistin methanesulfonate (CMS) is an important treatment option for infections caused by carbapenem-resistant Gram-negative organisms (CROs). This study evaluated the pharmacokinetic/pharmacodynamic (PK/PD) profiles and safety of CMS in Chinese subjects following a recommended dosage. A total of 12 healthy Chinese subjects received CMS injections at 2. Read More

Antibiotics (Basel) 2022 Jun 8;11(6). Epub 2022 Jun 8.

Department of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Hnevotinska 3, 779 00 Olomouc, Czech Republic.

This observational retrospective study aimed to analyze whether/how the spectrum of bacterial pathogens and their resistance to antibiotics changed during the worst part of the COVID-19 pandemic (1 November 2020 to 30 April 2021) among intensive care patients in University Hospital Olomouc, Czech Republic, as compared with the pre-pandemic period (1 November 2018 to 30 April 2019). A total of 789 clinically important bacterial isolates from 189 patients were cultured during the pre-COVID-19 period. The most frequent etiologic agents causing nosocomial infections were strains of (17%), (11%), (10%), coagulase-negative staphylococci (9%), (8%), (6%), (5%), (5%) and (5%). Read More

Antibiotics (Basel) 2022 Jun 7;11(6). Epub 2022 Jun 7.

Food Safety Unit, Department of Agricultural and Food Sciences Alma Mater Studiorum, University of Bologna, 40064 Ozzano dell'Emilia, Italy.

This study is focused on resistance to carbapenems and third-generation cephalosporins in Gram-negative microorganisms isolated from swine, whose transmission to humans via pork consumption cannot be excluded. In addition, the common carriage of carbapenem-resistant (CR) bacteria between humans and pigs was evaluated. Sampling involved 300 faecal samples collected from slaughtered pigs and 300 urine samples collected from 187 hospitalised patients in Parma Province (Italy). Read More

Antibiotics (Basel) 2022 Jun 7;11(6). Epub 2022 Jun 7.

Department of Pharmacy, School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.

Solutions are needed to inform antimicrobial stewardship (AMS) regarding balancing the access to effective antimicrobials with the need to control antimicrobial resistance. Theoretical and mathematical models suggest a non-linear relationship between antibiotic use and resistance, indicating the existence of thresholds of antibiotic use beyond which resistance would be triggered. It is anticipated that thresholds may vary across populations depending on host, environment, and organism factors. Read More

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Section of Microbiology, Department of Biomedical and Biotechnological Sciences (BIOMETEC), University of Catania, 95123 Catania, Italy.

The World Health Organization has identified antimicrobial resistance as a public health emergency and developed a global priority pathogens list of antibiotic-resistant bacteria that can be summarized in the acronym ESKAPE (, , , , and species), reminding us of their ability to escape the effect of antibacterial drugs. We previously tested new heteroaryl-ethylene compounds in order to define their spectrum of activity and antibacterial capability. Now, we focus our attention on PB4, a compound with promising MIC and MBC values in all conditions tested. Read More

Antibiotics (Basel) 2022 May 27;11(6). Epub 2022 May 27.

Institute of Food Sciences, CNR-ISA, Via Roma, 64, 83100 Avellino, Italy.

This work aimed to evaluate the chemical composition of the essential oils (EOs) of two cultivars of and their antibiofilm activity against the food pathogens , , , and . The crystal violet assay ascertained the susceptibility of the bacterial biofilms, while the MTT assay let to evaluations of the metabolic changes occurring in the bacterial cells within biofilms. Their chemical composition indicated some sulfuric compounds (i. Read More

Animals (Basel) 2022 Jun 14;12(12). Epub 2022 Jun 14.

Changchun Veterinary Research Institute, Chinese Academy of Agriculture Sciences, Changchun 130122, China.

With the development of modern pig raising technology, the increasing density of animals in pig houses leads to the accumulation of microbial aerosols in pig houses. It is an important prerequisite to grasp the characteristics of bacteria in aerosols in different pig houses to solve the problems of air pollution and disease prevention and control in different pig houses. This work investigated the effects of growth stages on bacterial aerosol concentrations and bacterial communities in pig houses. Read More

J Hazard Mater 2022 Aug 6;436:129284. Epub 2022 Jun 6.

College of Environmental Science and Engineering, Beijing Forestry University, Beijing 100083, China. Electronic address:

Defluorination is a key factor in reducing biologically accumulated carcinogenic and teratogenic toxicity of fluoroglucocorticoids (FGCs). To enhance defluorination efficiency, a highly efficient defluorination-degrading strain Acinetobacter. pittii C3 was isolated, and the promotion mechanism through humic acid (HA)-mediated biotransformation was investigated. Read More

J Hazard Mater 2022 Aug 3;436:129247. Epub 2022 Jun 3.

College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China.

Soil serves as a major reservoir of both antibiotic resistance genes (ARGs) and microplastics. However, the characteristics of the antibiotic resistome in the soil plastisphere remain largely unknown. In this study, we used metagenomic approaches to reveal the changing patterns of ARGs and the bacterial community and their associations in response to three types of microplastics (light density polyethylene, LDPE; polypropylene, PP; polystyrene, PS) using particles 550 µm or 75 µm in diameter. Read More

J Hazard Mater 2022 Aug 19;436:129185. Epub 2022 May 19.

LEPABE, Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal; ALiCE - Associate Laboratory in Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, 4200-465 Porto, Portugal. Electronic address:

Musk fragrances have been detected in drinking water (DW) at trace concentrations. However, their impact on the microbial quality of DW has been disregarded. This work provides a pioneer evaluation of the effects of two synthetic musks contaminants, tonalide (AHTN) and galaxolide (HHCB), in microbial biofilms formed on two different surfaces, polyvinyl chloride (PVC) and stainless steel AISI 316 (SS316). Read More

J Hazard Mater 2022 May 9;430:128455. Epub 2022 Feb 9.

Key Laboratory for Technology in Rural Water Management of Zhejiang Province, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China; College of Water Conservancy and Environmental Engineering, Zhejiang University of Water Resources and Electric Power, Hangzhou 310018, China. Electronic address:

Submerged macrophytes and their epiphytic biofilms are important media for metal transport/transformation in aquatic environment. However, the bacterial community structure and the contribution of the epiphytic biofilm to the heavy metal accumulation remain unclear. Therefore, in this study, water, sediment, submerged macrophyte (Potamogeton crispus L. Read More