16,424 results match your criteria Acinetobacter


Spatial and seasonal variation of the airborne microbiome in a rapidly developing city of China.

Sci Total Environ 2019 Feb 3;665:61-68. Epub 2019 Feb 3.

Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China; Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, China. Electronic address:

Exposure to airborne microbes (AM) can affect the human microbiome and has various consequences for human health. Investigating the profiles of AM and the potential bacterial pathogens within, along with the factors influencing their community, is pivotal for understanding the impact of AM on human health. In this study, we collected AM during spring and summer from 11 sites with various levels of urbanization in the city of Xiamen, China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.367DOI Listing
February 2019

Environmental Aspects of the Use of Extract in Bioremediation Process.

Microorganisms 2019 Feb 5;7(2). Epub 2019 Feb 5.

Institute of Chemical Technology and Engineering, Poznan University of Technology, Berdychowo 4, 60-965 Poznan, Poland.

This paper analyzes the impact of saponins from English ivy leaves on the properties of environmental bacterial strains and hydrocarbon degradation ability. For this purpose, two bacterial strains, M03 and M1B, have been used in toluene, 4-chlorotoluene, and α,α,α-trifluorotoluene biodegradation supported by extract. Moreover, theeffects of ivy exposition on cell properties and extract toxicity were investigated. Read More

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http://www.mdpi.com/2076-2607/7/2/43
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http://dx.doi.org/10.3390/microorganisms7020043DOI Listing
February 2019
1 Read

Carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA genes with an upstream ISAba1: The first report of a novel OXA subclass from Iran.

J Glob Antimicrob Resist 2019 Feb 11. Epub 2019 Feb 11.

Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Objectives: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates. Read More

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http://dx.doi.org/10.1016/j.jgar.2018.12.011DOI Listing
February 2019

Signal Transduction Proteins in : Role in Antibiotic Resistance, Virulence, and Potential as Drug Targets.

Front Microbiol 2019 30;10:49. Epub 2019 Jan 30.

Department of Microbiology, University of Manitoba, Winnipeg, MB, Canada.

is a notorious pathogen in health care settings around the world, primarily due to high resistance to antibiotics. also shows an impressive capability to adapt to harsh conditions in clinical settings, which contributes to its persistence in such conditions. Following their traditional role, the wo omponent ystems (TCSs) present in play a crucial role in sensing and adapting to the changing environmental conditions. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363711PMC
January 2019

Whole Genome Sequencing and Comparative Genomics Analyses of sp. XY-2, a New Species Capable of Biodegrade Tetracycline.

Front Microbiol 2019 29;10:33. Epub 2019 Jan 29.

School of Minerals Processing and Bioengineering, Central South University, Changsha, China.

Few bacteria are resistant to tetracycline and can even biodegrade tetracycline in the environment. In this study, we isolated a bacterium sp. XY-2, which could biodegrade 74% tetracycline at pH 7. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361800PMC
January 2019

A mycophenolic acid derivative from the fungus Penicillium sp. SCSIO sof101.

Nat Prod Res 2019 Feb 13:1-7. Epub 2019 Feb 13.

a Chongqing Center For Drug Safety Evaluation , Chongqing Academy of Chinese Materia Medica , Chongqing , China.

Mycophenolic acid (MPA) is a group of metabolite derived from several species of Penicillium, which shows potent bioactivity. In this study, a new derivative of MPA compound named penicacid D (1), was isolated from the marine derived fungus Penicillium sp. SCSIO sof101, along with seven known compounds (2-8). Read More

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http://dx.doi.org/10.1080/14786419.2018.1553881DOI Listing
February 2019

Eradication of persister cells of Acinetobacter baumannii through combination of colistin and amikacin antibiotics.

J Antimicrob Chemother 2019 Feb 12. Epub 2019 Feb 12.

Department of Molecular Cell Biology and Samsung Medical Center, Sungkyunkwan University School of Medicine, Suwon, South Korea.

Objectives: Persister cells following antibiotic exposure may cause failure of antibiotic treatment. The synergistic effects of antibiotic combinations with respect to eliminating persister cells were investigated based on their characteristics.

Methods: For Acinetobacter baumannii clinical isolates, persister assays were performed using colistin, amikacin, imipenem and ciprofloxacin in various ways, including exposure to antibiotics in combination and sequentially. Read More

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https://academic.oup.com/jac/advance-article/doi/10.1093/jac
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http://dx.doi.org/10.1093/jac/dkz034DOI Listing
February 2019
1 Read

Biofilm contamination of high-touched surfaces in intensive care units: epidemiology and potential impacts.

Lett Appl Microbiol 2019 Feb 13. Epub 2019 Feb 13.

Surgical Infection Research Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, Australia.

The aim of this study was to determine the epidemiology (location, microbial load, microbiome, presence/absence of biofilm, and pathogens, including ESKAPE - Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species, and antimicrobial susceptibility profiles) of the bacterial contamination on intensive care units (ICUs) surfaces. Fifty-seven high-touched surfaces were collected from adult, paediatric and neonatal ICUs from two large public Brazilian hospitals from central and north regions. Samples (~4cm ) were subjected to culture (qualitative), qPCR targeting 16s rRNA gene (microbial load - bacteria/cm ), 16s rRNA amplicon sequencing (microbiome analysis) and scanning electron (SEM) or confocal laser scanning microscopy (CLSM) (biofilm presence). Read More

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http://dx.doi.org/10.1111/lam.13127DOI Listing
February 2019

Current trends in the treatment of pneumonia due to multidrug-resistant Gram-negative bacteria.

F1000Res 2019 30;8. Epub 2019 Jan 30.

Department of Medicine, University of North Carolina, Chapel Hill, NC, 27514, USA.

Pneumonia is one of the most common infections worldwide. Morbidity, mortality, and healthcare costs increase substantially when pneumonia is caused by multidrug-resistant Gram-negative bacteria (MDR-GNB). The ongoing spread of antimicrobial resistance has made treating MDR-GNB pneumonia increasingly difficult. Read More

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http://dx.doi.org/10.12688/f1000research.16517.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354321PMC
January 2019

Metabolic Responses to Polymyxin Treatment in ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling.

mSystems 2019 Jan-Feb;4(1). Epub 2019 Feb 5.

Infection & Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Australia.

Multidrug-resistant (MDR) Acinetobacter baumannii has emerged as a very problematic pathogen over the past decades, with a high incidence in nosocomial infections. Discovered in the late 1940s but abandoned in the 1970s, polymyxins (i.e. Read More

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http://dx.doi.org/10.1128/mSystems.00157-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365644PMC
February 2019

Dose Optimization of Colistin Combinations against Carbapenem-Resistant from Chinese Hospital-acquired Pneumonia Patients Using PK/PD Model.

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Institute of Antibiotics, Huashan Hospital, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission & National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, 200040, China

Colistin-based combination therapy has become an important strategy to combat the carbapenem-resistant (CRAB). However, the optimal dosage regimen selection for the combination with the maximum efficacy is challenging. Checkerboard assay was employed to evaluate the synergy of colistin in combination with meropenem, rifampicin, fosfomycin and minocycline against nine carbapenem-resistant (Minimum inhibitory concentration of meropenem [MIC]≥32 mg/L) isolated from Chinese hospital-acquired pneumonia (HAP) patients. Read More

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http://dx.doi.org/10.1128/AAC.01989-18DOI Listing
February 2019
1 Read

Bacterial Cytological Profiling (BCP) as a tool to study mechanism of action of antibiotics that are active against .

Antimicrob Agents Chemother 2019 Feb 11. Epub 2019 Feb 11.

Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand

An increasing number of multidrug-resistant (MDR-) infections have been reported worldwide, posing a threat to public health. The establishment of methods to elucidate the mechanism of action (MOA) of -specific antibiotics is needed to develop novel antimicrobial therapeutics with activity against MDR- We previously developed bacterial cytological profiling (BCP) to understand the MOA of compounds in and Given how distantly related is to these species, it was unclear to what extent it could be applied. Here we implemented bacterial cytological profiling (BCP) as an antibiotic MOA discovery platform for We found that the BCP platform can distinguish among six major antibiotic classes and can also sub-classify antibiotics that inhibit the same cellular pathway but have different molecular targets. Read More

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http://dx.doi.org/10.1128/AAC.02310-18DOI Listing
February 2019

2-hydroxylation of lipid A contributes to virulence.

Infect Immun 2019 Feb 11. Epub 2019 Feb 11.

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom

causes a wide range of nosocomial infections. This pathogen is considered a threat to human health due to the increasing isolation of multidrug resistant strains. There is a major gap in knowledge on the infection biology of , and only few virulence factors have been characterized including the lipopolysaccharide. Read More

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http://dx.doi.org/10.1128/IAI.00066-19DOI Listing
February 2019

Enhancement of nitrogen removal by supplementing fluidized-carriers into the aerobic tank in a full-scale A/O system.

Sci Total Environ 2019 Apr 7;660:817-825. Epub 2019 Jan 7.

Faculty of Architectural, Civil Engineering and Environment, Ningbo University, Ningbo 315211, China.

Fluidized-carriers were supplemented into the aerobic tank of a full-scale wastewater treatment plant (WWTP) using an anaerobic/anoxic/aerobic (A/O) system to improve the nitrogen removal efficiency in effluents. The effects of carrier supplementation on denitrification ability and the bacterial community structures were investigated over 10 months. The results showed that the average effluent concentration of total nitrogen (TN) was maintained at 9. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.01.046DOI Listing

Piggery wastewater treatment by Acinetobacter sp. TX5 immobilized with spent mushroom substrate in a fixed-bed reactor.

Sci Total Environ 2018 Dec 23;644:1460-1468. Epub 2018 Jul 23.

College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Gutian Edible Fungi Research Institute, Fujian Agriculture and Forestry University, Gutian, Fujian, China.

Acinetobacter sp. TX5 immobilized with spent Hypsizygus marmoreus substrate (SHMS) was used to treat the raw piggery wastewater (RPW). In batch experiments, NH-N in the diluted RPW decreased from initial 34. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2018.07.076DOI Listing
December 2018

Bridging antimicrobial resistance knowledge gaps: The East African perspective on a global problem.

PLoS One 2019 11;14(2):e0212131. Epub 2019 Feb 11.

Microbiology Laboratory, Kenyatta National Hospital, Nairobi, Kenya.

Background: There is worldwide concern of rapidly increasing antimicrobial resistance (AMR). However, there is paucity of resistance surveillance data and updated antibiograms in Africa in general. This study was undertaken in Kenyatta National Hospital (KNH) -the largest public tertiary referral centre in East & Central Africa-to help bridge existing AMR knowledge and practice gaps. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212131PLOS
February 2019

The high prevalence of antibiotic heteroresistance in pathogenic bacteria is mainly caused by gene amplification.

Nat Microbiol 2019 Feb 11. Epub 2019 Feb 11.

Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.

When choosing antibiotics to treat bacterial infections, it is assumed that the susceptibility of the target bacteria to an antibiotic is reflected by laboratory estimates of the minimum inhibitory concentration (MIC) needed to prevent bacterial growth. A caveat of using MIC data for this purpose is heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells. We investigated the prevalence and mechanisms of heteroresistance in 41 clinical isolates of the pathogens Escherichia coli, Salmonella enterica, Klebsiella pneumoniae and Acinetobacter baumannii against 28 different antibiotics. Read More

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http://dx.doi.org/10.1038/s41564-018-0342-0DOI Listing
February 2019

Nitro Sulfonyl Fluorides are a new pharmacophore for the development of antibiotics.

Mol Syst Des Eng 2018 Aug 7;3(4):599-603. Epub 2018 Jun 7.

Department of Bioengineering, University of California, Berkeley, California, 94720, USA.

The development of antibiotics against Gram-negative bacteria is a central problem in drug discovery. In this report, we demonstrate that aromatic sulfonyl fluorides with a nitro group in their ortho position have remarkable antibacterial activity and are active against drug-resistant pathogens, such as methicillin-resistant Staphylococcus aureus (MRSA), multidrug resistant Acinetobacter baumannii, and Pseudomonas aeruginosa. Read More

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http://dx.doi.org/10.1039/C8ME00011EDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366622PMC

Fe(II)-dosed ceramic membrane bioreactor for wastewater treatment: Nutrient removal, microbial community and membrane fouling analysis.

Sci Total Environ 2019 Feb 2;664:116-126. Epub 2019 Feb 2.

Research Institute of Environmental Engineering & Nano-Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China; Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental Safety, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, Guangdong, China; School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

Ferrous dosing is used to reduce phosphorus concentration and alleviate polymeric membrane fouling in membrane bioreactor (MBR). However, limited studies have been conducted to investigate the impacts of ferrous dosing on ceramic membrane fouling, nutrient removal efficiency and microbial community. Accordingly, the aim of this study was to investigate the effect of intermittent ferrous dosing with Fe/P molar ratios of 2 and 1 (with a dosing frequency of every two days) on the overall nutrient removal, functional microbial changes and membrane fouling in ceramic membrane bioreactors (CMBR) in treatment of wastewater. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.019DOI Listing
February 2019

A cryogel-based bioreactor for water treatment applications.

Water Res 2019 Apr 31;153:324-334. Epub 2019 Jan 31.

School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, UK.

The aim of this study was to develop and test a non-diffusion limited, high cell density bioreactor for biodegradation of various phenol derivatives. The bioreactor was obtained using a straightforward one-step preparation method using cryostructuration and direct cross-linking of bacteria into a 3D structured (sponge-like) macroporous cryogel composite material consisting of 11.6% (by mass) cells and 1. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.028DOI Listing
April 2019
5.528 Impact Factor

Feces from wild Triatoma dimidiata induces local inflammation and specific immune response in a murine model

Ann Parasitol 2018 ;64(4):367-377

Centro de Investigaciones Biomédicas, Universidad Autonoma de Campeche, Patrico Trueba s/n, Campeche 24090, Mexico

In endemic regions for Triatoma dimidiata the vector for Chagas disease, subjects can be in contact with insect`s feces several times through a lifetime. The triatomine’s digestive tract is colonized by diverse but few dominant genera of microorganisms. The immune responses to microbiota feces are poorly known in mammal hosts. Read More

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January 2018

Characteristics of infectious complications in critically ill patients.

Wiad Lek 2018 ;71(9):1784-1792

National Pirogov Memorial Medical University, Vinnytsya, Ukraine.

Objective: Introduction: Patients, undergoing treatment in the intensive care units (ICU) often (51&) suffer from the infections and predominantly (71&) receive antibiotics. The aim: We aimed to review scientific literature, that highlights recent developments in etiology and emerge problems of struggling infectious complications in critically ill.

Patients And Methods: Materials and methods: We performed a search of literature from 1994 to 2018 years in Google Scholar, PubMed, MedLine, Embase, Cochrane. Read More

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January 2018

Ten-year surveillance study of ventilator-associated pneumonia at a tertiary care center in Lebanon.

J Infect Public Health 2019 Feb 5. Epub 2019 Feb 5.

Division of Infectious Diseases, American University of Beirut Medical Center, Beirut, Lebanon; Infection Control and Prevention Program, American University of Beirut Medical Center, Beirut, Lebanon. Electronic address:

Background: Ventilator-associated pneumonia (VAP) is associated with significant adverse outcomes in critically-ill patients admitted to the Intensive Care Unit (ICU). Systematic data from Lebanon on VAP are not available and large epidemiological studies from the region are scarce.

Methods: We conducted a retrospective study over a 10-year period at the American University of Beirut Medical Center (AUBMC), a tertiary referral center in Lebanon in order to describe the incidence, microbiology, and temporal trends of VAP in the medical/surgical ICU. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.01.057DOI Listing
February 2019
1 Read

Monitoring Cr toxicity and remediation processes - combining a whole-cell bioreporter and Cr isotope techniques.

Water Res 2019 Apr 21;153:295-303. Epub 2019 Jan 21.

Department of Engineering Science, University of Oxford, Parks Road, Oxford, OX1 3PJ, United Kingdom.

Bioremediation is a sustainable and cost-effective means of contaminant detoxification. Although Cr(VI) is toxic at high concentrations, various microbes can utilise it as an electron accepter in the bioremediation process, and reduce it to the less toxic form Cr(III). During remediation, it is important to monitor the level of toxicity and effectiveness of Cr(VI) reduction in order to optimize the conditions. Read More

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http://dx.doi.org/10.1016/j.watres.2019.01.009DOI Listing

[Polyresistent microflora in the structure of microorganisms divided from blood of patients of the general hospital.]

Klin Lab Diagn 2018 ;63(9):574-578

Samara State Medical University, 43099, Samara, Russia.

The aim of our research was to evaluate the structure and the determination of the phenotypes of antibiotic resistance of microflora isolated from patients' blood in a multidisciplinary hospital during the period from 2013 to 2017. The material was taken into BacT / ALERT bottles containing nutrient media, followed by incubation of blood. In case of a positive result, the material from the vials was dispersed into dense nutrient media. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-9-574-578DOI Listing
January 2018

Pneumonia in hospitalized neurologic patients: trends in pathogen distribution and antibiotic susceptibility.

Antimicrob Resist Infect Control 2019 1;8:25. Epub 2019 Feb 1.

1Department of Neurology, Laboratory for Neurotherapeutics, Biomedical Research Institute, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744 South Korea.

Background: Bed-ridden state, dysphagia, altered mental state, or respiratory muscle weakness are common in neurologic patients and increase the risk of pneumonia. The major causes of pneumonia in neurologic patients may differ from those in the general population, resulting in a different pathogen distribution. We investigated the trends of pathogen distribution in culture-positive pneumonia in hospitalized neurologic patients and the related antibiotic resistance in those with hospital-acquired pneumonia (HAP). Read More

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http://dx.doi.org/10.1186/s13756-019-0475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359823PMC
February 2019
1 Read

Antibacterial activity of soil bacteria isolated from Kochi, India and their molecular identification.

J Genet Eng Biotechnol 2018 Dec 14;16(2):287-294. Epub 2018 Jun 14.

Optimurz Bio & IT Solutions, Shenoy Nagar West, Chennai 600 030, Tamil Nadu, India.

The present study, deal about the antibiosis activity of soil bacteria, isolated from 10 different locations of rhizosphere and diverse cultivation at Kochi, Kerala, India. The bacteria were isolated by standard serial dilution plate techniques. Morphological characterization of the isolate was done by Gram's staining and found that all of them gram positive. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353780PMC
December 2018

Study the antibacterial and antibiofilm activity of Carum copticum against antibiotic-resistant bacteria in planktonic and biofilm forms.

Microb Pathog 2019 Feb 4;129:99-105. Epub 2019 Feb 4.

Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.

Objectives: Microbial biofilms has attracted interest in the recent years because they has become the most important cause of nosocomial infections. This study was aimed to examine the antibacterial activities of Carum copticum extracts on the development of microbial biofilms and planktonic form of six pathogenic bacteria.

Methods: Antimicrobial activity of the crude extracts against the planktonic form of six pathogenic bacteria: Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumonia was evaluated by using the disc diffusion method. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.02.002DOI Listing
February 2019
2 Reads

Outcome Following the Treatment of Ventriculitis Caused by Multi/Extensive Drug Resistance Gram Negative Bacilli; and .

Front Neurol 2018 23;9:1174. Epub 2019 Jan 23.

Neurosurgery Department, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.

CNS ventriculitis is a serious complication following an intracranial insult that demands immediate treatment with broad-spectrum antibiotics in a critical care setting. Infections due to multi/extensive drug resistance (MDR/XDR) microorganisms are very challenging, which may demand an additional approach to the ongoing practice; intravenous and intraventricular administration of antibiotics. To study the efficacy and safety of thorough ventricular irrigation followed by daily intraventricular antibiotic administration in patients with MDR/XDR ventriculitis. Read More

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http://dx.doi.org/10.3389/fneur.2018.01174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352847PMC
January 2019
1 Read

AHLs-produced bacteria in refrigerated shrimp enhanced the growth and spoilage ability of .

J Food Sci Technol 2019 Jan 8;56(1):114-121. Epub 2018 Nov 8.

College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, 266003 China.

is the predominant bacteria in spoiled shrimp (), however, the spoilage ability and the mechanism of is still unknown. can't produce the signal molecule of acyl-homoserine-lactones (AHLs), so the aim of this study was to investigate how wild type SA03 (WT SA03) eavesdrop exogenous AHLs to enhance its spoilage ability through LuxR receptor. The results indicated that spp. Read More

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http://link.springer.com/10.1007/s13197-018-3464-8
Publisher Site
http://dx.doi.org/10.1007/s13197-018-3464-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342784PMC
January 2019
4 Reads

[Late onset neonatal sepsis in an intensive care neonatal unit: etiological agents and most frequent location].

Rev Chilena Infectol 2018 ;35(5):547-552

Ministerio de Salud Pública y Bienestar Social, Hospital Nacional de Itaugua Guazu, Itaugua, Paraguay.

Introduction: Nosocomial neonatal sepsis (NNS) is a frequent entity in intensive care units, causing great morbidity and mortality. The most frequent site is blood, followed by lungs and urine.

Objective: To know the etiology and most frequent localization of infection in the NNS. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500547DOI Listing
January 2018

Diversity of Ocular Surface Bacterial Microbiome Adherent to Worn Contact Lenses and Bacterial Communities Associated With Care Solution Use.

Eye Contact Lens 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology (M.A.R, P.K.M., M.A.G.), Center for Medical Mycology, Case Western Reserve University, Cleveland, OH; Department of Ophthalmology and Visual Sciences (L.S.-F.), University Hospitals Eye Institute, University Hospitals Cleveland Medical Center, Cleveland, OH; and Department of Population and Quantitative Health Sciences (S.D., S.K.I., B.R., M.C.), Case Western Reserve University, Cleveland, OH.

Purpose: This study assessed microbiome adherent to contact lenses and defined the bacterial communities associated with use of lens care solutions.

Methods: Among 84 lenses screened for adherent ocular surface bacterial microbiome using 16S rRNA molecular amplification, 63 (75%) generated bacterial-specific amplicons processed using the Ion Torrent Personal Genome Machine workflow. Data were stratified by solution use (peroxide vs. Read More

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http://dx.doi.org/10.1097/ICL.0000000000000578DOI Listing
February 2019
1 Read

Plazomicin: A Novel Aminoglycoside for the Treatment of Resistant Gram-Negative Bacterial Infections.

Drugs 2019 Feb 6. Epub 2019 Feb 6.

Department of Pharmacy Services, Sinai-Grace Hospital, Detroit Medical Center, Wayne State University of School of Medicine, Detroit, MI, USA.

Plazomicin is a novel semisynthetic parenteral aminoglycoside that inhibits bacterial protein synthesis. It was approved by the United States Food and Drug Administration for use in adults with complicated urinary tract infections (cUTI), including pyelonephritis. Plazomicin displays potent in vitro activity against Enterobacteriaceae, including both extended-spectrum β-lactamase-producing and carbapenem-resistant isolates. Read More

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http://dx.doi.org/10.1007/s40265-019-1054-3DOI Listing
February 2019

Identification of Novel Host Fatty Acid Stress Adaptation Strategies.

MBio 2019 Feb 5;10(1). Epub 2019 Feb 5.

Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia

Free fatty acids hold important immune-modulatory roles during infection. However, the host's long-chain polyunsaturated fatty acids, not commonly found in the membranes of bacterial pathogens, also have significant broad-spectrum antibacterial potential. Of these, the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid decosahexaenoic acid (DHA) are highly abundant; hence, we investigated their effects on the multidrug-resistant human pathogen Our analyses reveal that AA and DHA incorporate into the bacterial membrane and impact bacterial fitness and membrane integrity, with DHA having a more pronounced effect. Read More

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http://dx.doi.org/10.1128/mBio.02056-18DOI Listing
February 2019

Clinical and laboratory-induced colistin-resistance mechanisms in Acinetobacter baumannii.

Microb Genom 2019 Feb 5. Epub 2019 Feb 5.

2​Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

The increasing incidence and emergence of multi-drug resistant (MDR) Acinetobacter baumannii has become a major global health concern. Colistin is a historic antimicrobial that has become commonly used as a treatment for MDR A. baumannii infections. Read More

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http://dx.doi.org/10.1099/mgen.0.000246DOI Listing
February 2019

To assess the stethoscope cleaning practices, microbial load and efficacy of cleaning stethoscopes with alcohol-based disinfectant in a tertiary care hospital.

J Infect Prev 2019 Jan 7;20(1):46-50. Epub 2018 Nov 7.

All India Institute of Medical Sciences, Bhopal, India.

Background: The objectives of our study were to study the stethoscope cleaning practices of medical personnel and to assess the microbial load on stethoscopes and efficacy of cleaning stethoscopes with alcohol-based disinfectant.

Methodology: A questionnaire-based cross-sectional study was conducted among medical personnel at a tertiary care hospital in India to assess their knowledge and cleaning practices regarding stethoscope disinfection. Samples from the stethoscopes were collected before and after cleaning with alcohol-based disinfectant. Read More

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http://dx.doi.org/10.1177/1757177418802353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346325PMC
January 2019

Treatment of severe ventriculitis caused by extensively drug-resistant by intraventricular lavage and administration of colistin.

Infect Drug Resist 2019 21;12:241-247. Epub 2019 Jan 21.

Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China,

Background: Severe ventriculitis (SV) caused by multidrug-resistant bacteria is associated with high morbidity and mortality in neurosurgical patients. This study assessed the outcomes of patients with SV caused by who were treated by intraventricular (IVT) lavage and colistin administration.

Methods: This retrospective study included consecutive patients with SV caused by who were admitted at the Neurosurgical Department of Shanghai Tenth People's Hospital from January 2014 to September 2017. Read More

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http://dx.doi.org/10.2147/IDR.S186646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345184PMC
January 2019
1 Read

Oil-Spill Triggered Shift in Indigenous Microbial Structure and Functional Dynamics in Different Marine Environmental Matrices.

Sci Rep 2019 Feb 4;9(1):1354. Epub 2019 Feb 4.

National Centre for Sustainable Coastal Management (NCSCM), Ministry of Environment, Forest and Climate Change (MoEFCC), Chennai, 600025, India.

Microbial degradation has long been recognized as the key rescue mechanism in shaping the oil polluted marine environments and the role of indigenous populations or their functional genomics have never been explored from Indian marine environments, post an oil spill event. In the current study, high throughput metagenomic analysis, PLFA profiling and mass spectrophotometric analysis was performed in combination with metabolomics to capture signature variations among the microbial communities in sediment, water and laboratory enrichments. Contrary to the previous reports, the bloom of Pseudomonadales (specifically genus Acinetobacter) in oiled sediment and Methylococcales in oiled water outnumbered the relative abundance of Alcanivorax in response to hydrocarbon contamination. Read More

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http://dx.doi.org/10.1038/s41598-018-37903-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361881PMC
February 2019

The contribution of active iron-uptake to pathogenicity.

Infect Immun 2019 Feb 4. Epub 2019 Feb 4.

Department of Science, Roma Tre University, Rome, Italy

is an important nosocomial pathogen. Mechanisms that allow to cause human infection are still poorly understood. Iron is an essential nutrient for bacterial growth , and the multiplicity of iron-uptake systems in suggests that iron acquisition contributes to the ability of to cause infection. Read More

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http://dx.doi.org/10.1128/IAI.00755-18DOI Listing
February 2019
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Novel Antimicrobial Indolepyrazines A and B from the Marine-Associated sp. ZZ1275.

Mar Drugs 2019 Feb 1;17(2). Epub 2019 Feb 1.

Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China.

Two new alkaloids indolepyrazines A () and B () were isolated from the marine-derived sp. ZZ1275. Their structures were elucidated through extensive nuclear magnetic resonance (NMR) spectroscopic analyses, high resolution electrospray ionization mass spectroscopy (HRESIMS) data, and electronic circular dichroism (ECD) calculation. Read More

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http://dx.doi.org/10.3390/md17020089DOI Listing
February 2019
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Cefiderocol: A Siderophore Cephalosporin with Activity Against Carbapenem-Resistant and Multidrug-Resistant Gram-Negative Bacilli.

Drugs 2019 Feb 2. Epub 2019 Feb 2.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

Cefiderocol is an injectable siderophore cephalosporin discovered and being developed by Shionogi & Co., Ltd., Japan. Read More

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http://dx.doi.org/10.1007/s40265-019-1055-2DOI Listing
February 2019
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The fates of microbial populations on pig carcasses during slaughtering process, on retail cuts after slaughter, and intervention efficiency of lactic acid spraying.

Int J Food Microbiol 2019 Jan 25;294:10-17. Epub 2019 Jan 25.

National Institute of Animal Science, Rural Development Administration, Wanju 55365, Republic of Korea. Electronic address:

This study was conducted to detect and identify microbial populations on pig carcasses at different slaughtering stages and on retail pork cuts at 24 h after slaughter as well as to evaluate the intervention efficiency of sprays containing different concentrations (2% and 4%) of lactic acid. The sprays were applied to the carcass surfaces at the end of the slaughter line. Microbial samples were collected from carcass surfaces after bleeding and after eviscerating, and from retail cuts at 24 h after chilling/spraying. Read More

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http://dx.doi.org/10.1016/j.ijfoodmicro.2019.01.015DOI Listing
January 2019
3.082 Impact Factor

Investigation of multidrug-resistant ST2 Acinetobacter baumannii isolated from Saint George hospital in Lebanon.

BMC Microbiol 2019 Feb 2;19(1):29. Epub 2019 Feb 2.

Aix Marseille Univ, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19-21 boulevard Jean Moulin, 13385, Marseille, Cedex 05, France.

Background: Acinetobacter baumannii is an opportunistic pathogen causing various nosocomial infections. The spread of multidrug-resistant A. baumannii is a major public health problem. Read More

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http://dx.doi.org/10.1186/s12866-019-1401-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359860PMC
February 2019
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Bacteriologic Profile and Susceptibility Pattern of Mechanically - Ventilated Pediatric Patients with Pneumonia.

J Glob Antimicrob Resist 2019 Jan 30. Epub 2019 Jan 30.

Department of Pediatrics, Alexandria University, Faculty of Medicine, El-Shatby Hospital, Alexandria, Egypt. Electronic address:

Purpose: Therapy of severe pneumonia is very challenging in view of the current widespread bacterial resistance to many antibiotics especially extended spectrum ß-lactams, carbapenems, and anti-pseudomonal drugs. The current study aimed at assessing antimicrobial sensitivity pattern and optimization of the antibiotic stewardship program applied in a university affiliated pediatric intensive care unit (PICU).

Subjects And Methods: This prospective cohort study included all patients aged 1 month to 12 years, admitted to the PICU with severe pneumonia episodes indicated for mechanical ventilation, and were followed up and investigated. Read More

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http://dx.doi.org/10.1016/j.jgar.2019.01.028DOI Listing
January 2019
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Colistin Use in Patients with Extreme Renal Function: From Dialysis to Augmented Clearance.

Medicina (Kaunas) 2019 01 31;55(2). Epub 2019 Jan 31.

Department of Pharmacology, Riga Stradins University, Pilsonu Street 13, Riga, LV-1002, Latvia.

Colistin is used for the treatment of multidrug-resistant (MDR) Gram-negative bacteria infection in critically ill patients. It is recommended to adjust the dose in cases of renal impairment but not in cases of augmented renal clearance (ARC). The aim of this study was to determine colistin use pattern in patients with different renal functional states. Read More

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http://dx.doi.org/10.3390/medicina55020033DOI Listing
January 2019

ESCMID-EUCIC clinical guidelines on decolonisation of multidrug-resistant Gram-negative bacteria carriers.

Clin Microbiol Infect 2019 Jan 29. Epub 2019 Jan 29.

Division of Infectious Diseases, Microbiology and Preventive Medicine, Hospital Universitario Virgen Macarena / Department of Medicine, University of Seville / Biomedicine Institute of Seville (IBiS), Seville, Spain.

Scope: The aim of these guidelines is to provide recommendations for decolonising regimens targeting multidrug-resistant Gram-negative bacteria (MDR-GNB) carriers in all settings.

Methods: These evidence-based guidelines were produced after a systematic review of published studies on decolonisation interventions targeting the following MDR-GNB: third-generation cephalosporin-resistant Enterobacteriaceae (3GCephRE), carbapenem-resistant Enterobacteriaceae (CRE), aminoglycoside-resistant Enterobacteriaceae (AGRE), fluoroquinolone-resistant Enterobacteriaceae (FQRE), extremely drug-resistant Pseudomonas aeruginosa (XDRPA), carbapenem-resistant Acinetobacter baumannii (CRAB), cotrimoxazole-resistant Stenotrophomonas maltophilia (CRSM), colistin-resistant Gram-negative organisms (CoRGNB), pan-drug-resistant Gram-negative organisms (PDRGNB). The recommendations are grouped by MDR-GNB species. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.01.005DOI Listing
January 2019

Biosynthesis of Ag and Cu NPs by secondary metabolites of usnic acid and thymol with biological macromolecules aggregation and antibacterial activities against multi drug resistant (MDR) bacteria.

Int J Biol Macromol 2019 Jan 29. Epub 2019 Jan 29.

Department of Nanobiotechnology, Faculty of Science, Razi University, Kermanshah, Iran; Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran. Electronic address:

Thymol and usnic acid as the important secondary metabolites of respectively Artemisia haussknechtii and Protoparmeliopsis muralis were used for reduction and stabilizing of AgNO and CuSO in metal nanoparticles (MNPs) biosynthesis process. Antibacterial effects of prepared Ag-thymol (ATNPs), Ag-usnic acid (AUNPs), Cu-thymol (CTNPs), and Cu-usnic acid (CUNPs) on multi drug resistant (MDR) bacteria including methicillin-resistant Staphylococcus aureus (MRSA) (gram positive), Acinetobacter baumannii (A52), and Klebsiella pneumonia (K38) (gram negative) were compared with thymol, usnic acid, AgNO, CuSO, and tetracycline. Results of this study showed higher antibacterial activities of usnic acid, CUNPs, and CTNPs with MIC/MBC values (20, 40, and 40 μg/mL, respectively) than ATNPs and AUNPs against MRSA bacteria. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.01.177DOI Listing
January 2019
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Acinetobacter baumannii Biofilm Biomass Mediates Tolerance to Cold Plasma Exposure.

Lett Appl Microbiol 2019 Feb 1. Epub 2019 Feb 1.

Biofilm Research Group, School of Pharmacy, Queen's University Belfast, BT9 7BL, UK.

Acinetobacter baumannii is an intrinsically multi-drug resistant pathogen that, when existing as a biofilm, confers increased environmental tolerance to desiccation, nutrient starvation as well as increased tolerance to antimicrobials. Outbreaks of A. baumannii infections within the clinical setting are often associated with the biofilm phenotype. Read More

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http://dx.doi.org/10.1111/lam.13122DOI Listing
February 2019

The Water Hyacinth Microbiome: Link Between Carbon Turnover and Nutrient Cycling.

Microb Ecol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, MG, 31270-901, Brazil.

Water hyacinth (WH), a large floating plant, plays an important role in the biogeochemistry and ecology of many freshwaters globally. Its biogeochemical impact on wetland functioning is strongly mediated by the microbiome associated with its roots. However, little is known about the structure and function of this WH rhizobiome and its relation to wetland ecosystem functioning. Read More

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http://dx.doi.org/10.1007/s00248-019-01331-9DOI Listing
February 2019

A Porcine Wound Model of Infection.

Adv Wound Care (New Rochelle) 2019 Jan 5;8(1):14-27. Epub 2019 Jan 5.

Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland.

To better understand pathogenesis and to advance drug discovery against this pathogen, we developed a porcine, full-thickness, excisional, monospecies infection wound model. The research was facilitated with AB5075, a previously characterized, extensively drug-resistant . isolate. Read More

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http://dx.doi.org/10.1089/wound.2018.0786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350066PMC
January 2019
4 Reads