16,136 results match your criteria Acinetobacter
Water Res 2018 Nov 14;149:596-606. Epub 2018 Nov 14.
State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; National Engineering Laboratory for VOCs Pollution Control Material & Technology, University of Chinese Academy of Sciences, Beijing, 101408, China. Electronic address:
Wastewater treatment plants (WWTPs) are major sources of airborne bacteria, which could pose health risks to WWTP workers and surrounding residents. In this study, air samples were collected from various treatment facilities of a typical WWTP. Community compositions of airborne bacteria were identified by high-throughput sequencing technique. Read More
PLoS One 2018 6;13(12):e0208468. Epub 2018 Dec 6.
Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, Thailand.
Conjugation is a type of horizontal gene transfer (HGT) that serves as the primary mechanism responsible for accelerating the spread of antibiotic resistance genes in Gram-negative bacteria. The present study aimed to elucidate the mechanisms underlying the conjugation-mediated gene transfer from the extensively drug-resistant Acinetobacter baumannii (XDR-AB) and New Delhi Metallo-beta-lactamase-1-producing Acinetobacter baumannii (NDM-AB) to environmental isolates of Acinetobacter spp. Conjugation experiments demonstrated that resistance to ticarcillin and kanamycin could be transferred from four donors to two sodium azide-resistant A. Read More
Curr Opin Infect Dis 2018 Dec 4. Epub 2018 Dec 4.
Medical and infectious diseases ICU (MI2) APHP Bichat University Hospital.
Purpose Of Review: We reviewed recent data about epidemiology of Acinetobacter baumannii, resistance mechanisms, and therapeutic options for severe infections caused by multidrug-resistant strains.
Recent Findings: A. baumannii is a major cause of nosocomial infections affecting mainly to debilitating patients in the ICU, although the spread to regular wards and to long-term care facilities is increasing. Read More
Analyst 2018 Dec 6. Epub 2018 Dec 6.
Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan. and Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan and Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan.
Periprosthetic joint infections (PJIs) are among the most severe complications emerging from prosthetic joint replacement surgeries. In order to possess a rapid means of diagnosing PJIs, an integrated microfluidic system was developed herein for detecting and identifying bacteria in human synovial fluid (HSF). The entire molecular diagnostic process, including (1) sample treatment, (2) bacterial isolation, (3) bacterial lysis, (4) nucleic acid amplification (via polymerase chain reaction (PCR)), and (5) optical detection, could be automated on a single chip. Read More
Gut Pathog 2018 29;10:49. Epub 2018 Nov 29.
7Physics Department, Boston University, Boston, USA.
Background: The role of microbiota in Crohn's disease (CD) is increasingly recognized. However, most of the reports are from Western populations. Considering the possible variation from other populations, the aim of this study was to describe the microbiota profile in children with CD in Saudi Arabia, a non-Western developing country population. Read More
Infect Drug Resist 2018 13;11:2249-2255. Epub 2018 Nov 13.
Department of Emergency, Shengjing Hospital Affiliated to China Medical University, Heping District, Shenyang, Liaoning Province 110004, People's Republic of China,
Purpose: To study the distribution of pathogenic bacteria in ventilator-associated pneumonia (VAP), and epidemiological characteristics of extended-spectrum β lactamase (ESBL)-producing bacteria.
Patients And Methods: Lower respiratory tract secretions from 156 patients with mechanical ventilation were collected using a protective specimen brush (PSB), with quantitative bacterial culture carried out and antibiotic sensitivity measured. ESBLs produced by Gram-negative bacilli were detected using the double disk diffusion method and monitored by plasmid profiles. Read More
Infect Drug Resist 2018 8;11:2187-2197. Epub 2018 Nov 8.
Victor Babeș University of Medicine and Pharmacy, Timisoara, Romania,
Purpose: The purpose of this study was to identify risk factors for extensively drug-resistant (XDR) (AB) and XDR association in the largest intensive care unit (ICU) in Western Romania.
Materials And Methods: This retrospective case-controlled study was conducted between January 2016 and December 2016 in the ICU of the "Pius Brînzeu" County Emergency Clinical Hospital of Timi oara. Data were collected, in strict confidentiality, from the electronic database of the Microbiology Laboratory and the hospital's electronic medical records. Read More
Microb Pathog 2018 Nov 30. Epub 2018 Nov 30.
School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China. Electronic address:
Purpose: The study aims to explore the characteristic microorganisms of the common tongue coatings in patients with gastric cancer (GC).
Methods: A total of 115 GC patients were assigned to four groups: White-thin coating (W-thin) group, White-thick coating (W-thick) group, Yellow-thin coating (Y-thin) group and Yellow-thick coating (Y-thick) group. Thirty-five healthy volunteers with White-thin coating were recruit as controls. Read More
Microb Drug Resist 2018 Dec 1. Epub 2018 Dec 1.
1 Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, Faculty of Science and Medicine, University of Fribourg , Fribourg, Switzerland .
Objectives: Owing to the emergence of colistin resistance in nonfermenting Gram negative bacteria, reliable and rapid techniques for testing colistin susceptibility are needed. We evaluated the performances of the Rapid Polymyxin Acinetobacter and Pseudomonas tests using a collection of Acinetobacter baumannii and Pseudomonas aeruginosa clinical isolates.
Methods: Colistin susceptibility of A. Read More
Antimicrob Resist Infect Control 2018 26;7:145. Epub 2018 Nov 26.
1Institute of Hygiene, University Hospital I of Witten/Herdecke, Cologne Merheim Medical Centre, Cologne, Germany.
Background: is a common nosocomial pathogen known for its high transmission potential. A high rate of carbapenem-susceptible (ACB)-complex in clinical specimens led to the implementation of a pathogen-based surveillance on a 32-bed surgical intensive care unit (SICU) in a German tertiary care centre.
Methods: Between April 2017 and March 2018, ACB-complex isolates with an epidemiological link to the SICU were further assessed. Read More
Front Microbiol 2018 16;9:2780. Epub 2018 Nov 16.
School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China.
Cobalamin deficiency is believed to be related to disturbances in cell division, neuropathy, nervous system disease and pernicious anemia. Elderly people are usually advised to supplement their diets with cobalamin. As cobalamin has several forms, the effects of different forms of cobalamin on gut microbiota were investigated in this study. Read More
Front Microbiol 2018 16;9:2776. Epub 2018 Nov 16.
Biomedicine Discovery Institute, Infection and Immunity Program, Department of Microbiology, Monash University, Clayton, VIC, Australia.
Polymyxins are a last-line class of antibiotics against multidrug-resistant ; however, polymyxin resistance can emerge with monotherapy. Therefore, synergistic combination therapy is a crucial strategy to reduce polymyxin resistance. This study conducted untargeted metabolomics to investigate metabolic responses of a multidrug-resistant (MDR) clinical isolate, AB090342, to colistin and aztreonam alone, and their combination at 1, 4, and 24 h. Read More
Saudi J Biol Sci 2018 Nov 29;25(7):1369-1374. Epub 2018 May 29.
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
The objectives of this research were to identify certain chemical compounds that may be used as fingerprints of Saudi honey and to evaluate their antioxidant and antibacterial activities. Eleven Saudi 'monofloral' honey samples were analyzed and evaluated. Non-phenolic compounds, such as 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, methyl 3-hydroxyhexanaote and 5-hydroxymethyl-2-furancarboxaldehyde were present in different types of tested honey samples. Read More
Microb Pathog 2018 Nov 29. Epub 2018 Nov 29.
Department of Pharmaceutics and Pharmaceutical Technology, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah, 30078, Saudi Arabia; Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, 35516, Egypt. Electronic address:
High incidence of antibiotic resistance among bacterial clinical isolates necessitates the discovery of new targets for inhibition of microbial pathogenicity without stimulation of microbial resistance. This could be achieved by targeting virulence determinants which cause host damage and disease. Many pathogenic bacteria elaborate signaling molecules for cellular communication. Read More
Am J Infect Control 2018 Nov 29. Epub 2018 Nov 29.
AP-HP, GH St-Louis-Lariboisière, Department of Anesthesiology and Critical Care and Burn Unit, Paris, France; Université Paris Diderot, Paris, France; UMR INSERM 942, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France; F-CRIN, INICRCT Network, Paris, France.. Electronic address:
Background: Multidrug-resistant (MDR) bacteria outbreaks represent a major threat in intensive care units. Patients may then be exposed to drug-related direct toxicity during such outbreaks. The objective of this study was to explore the impact of an outbreak of imipenem-resistant Acinetobacter baumannii (IR-AB) on renal outcomes. Read More
Biochem Biophys Res Commun 2018 Nov 27. Epub 2018 Nov 27.
Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea; Catholic Photomedicine Research Institute, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. Electronic address:
Nanoparticles have been widely used as drug carriers, and finding new materials for them is important for efficient drug delivery. Herein, we developed a new nanoparticle using emulsan and flax seed oil. Emulsan is one of the representative biosurfactants obtained from Acinetobacter calcoaceticus RAG-1. Read More
Arh Hig Rada Toksikol 2017 Jun;68(2):99-108
University of Zagreb, Faculty of Science, Department of Biology,Split, Croatia.
The aim of this study was to determine the susceptibility of hospital and environmental Acinetobacter baumannii isolate biofilms on ceramics and glass to common disinfectants benzalkonium chloride and chlorhexidine. For this purpose we developed a new method for biofilm cultivation and quantification on ceramics. The biofilm bacteria were more resistant to disinfectants than the planktonic populations, as more than 50 % of the biofilm population and none of the planktonic population survived 5-minute exposure. Read More
J Med Microbiol 2018 Dec 5. Epub 2018 Dec 5.
1College of Medicine, Júlio Muller Hospital University, Federal University of Mato Grosso, Mato Grosso State, Brazil.
Purpose: Acinetobacter baumannii is a major cause of multidrug-resistant nosocomial infections. The characteristics of A. baumannii at two hospitals in a city in Central Brazil are described by analysing the phenotypes and molecular profiles of isolates recovered from 87 patients. Read More
Front Microbiol 2018 20;9:2804. Epub 2018 Nov 20.
Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, OH, United States.
Biofilm formation is a common strategy utilized by bacterial pathogens to establish persistence in a host niche. serovar Typhi, the etiological agent of Typhoid fever, relies on biofilm formation in the gallbladder to chronically colonize asymptomatic carriers, allowing for transmission to uninfected individuals. serovar Typhimurium utilizes biofilms to achieve persistence in human and animal hosts, an issue of both clinical and agricultural importance. Read More
Microorganisms 2018 Dec 3;6(4). Epub 2018 Dec 3.
School of Biomedical Science, The University of Western Australia, Crawley, WA, 6009, Australia.
Essential oils from the Western Australian (WA) mallee species , , and subsp. and subsp. were hydrodistilled from the leaves and then analysed by gas chromatography⁻mass spectrometry in addition to a commercial oil and 1,8-cineole. Read More
Microb Pathog 2018 Dec 1. Epub 2018 Dec 1.
Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Electronic address:
Bacterial infections caused by antibiotic resistant bacteria are the leading cause of morbidity and mortality after burn injuries. This issue has driven the need for promising antimicrobial drugs to eradication of bacterial pathogens. Accordingly, we aimed to determine the therapeutic value of melittin, as a natural Antimicrobial peptide (AMP), in eradication of extensively drug-resistant (XDR) Acinetobacter spp. Read More
Acta Crystallogr F Struct Biol Commun 2018 Dec 16;74(Pt 12):765-769. Epub 2018 Nov 16.
Department of Biotechnology, HungKuang University, Taichung, Taiwan.
Undecaprenyl pyrophosphate (UPP) is an important carrier of the oligosaccharide component in peptidoglycan synthesis. Inhibition of UPP synthase (UPPS) may be an effective strategy in combating the pathogen Acinetobacter baumannii, which has evolved to be multidrug-resistant. Here, A. Read More
World J Microbiol Biotechnol 2018 Dec 3;34(12):189. Epub 2018 Dec 3.
Department of Microbiology and Immunology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt.
Acinetobacter baumannii is an opportunistic pathogen that has been held responsible for a lot of infections worldwide. Infections caused by this pathogen are difficult to control because of the widespread of antimicrobial resistance mechanisms. The aim of the present study is to assess the prevalence of extended spectrum β-lactamases (ESBLs) and AmpC β-lactamases among isolates of A. Read More
Front Microbiol 2018 19;9:2698. Epub 2018 Nov 19.
Institute of Animal Nutrition and Functional Plant Compounds, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Vienna, Austria.
There is a great interest to understand the impact of the gut microbiota on host's nutrient use and FE in chicken production. Both chicken's feed intake and gut bacterial microbiota differ between high and low-feed efficient chickens. To evaluate the impact of the feed intake level on the feed efficiency (FE)-associated variation in the chicken intestinal microbiota, differently feed efficient chickens need to eat the same amount of feed, which can be achieved by feeding chickens restrictively. Read More
Lancet Infect Dis 2018 Dec 25;18(12):1319-1328. Epub 2018 Oct 25.
Shionogi & Co Ltd, Osaka, Japan.
Background: Carbapenem-resistant Gram-negative bacteria represent the highest priority for addressing global antibiotic resistance. Cefiderocol (S-649266), a new siderophore cephalosporin, has broad activity against Enterobacteriaceae and non-fermenting bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, including carbapenem-resistant strains. We assessed the efficacy and safety of cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infection in patients at risk of multidrug-resistant Gram-negative infections. Read More
BMC Infect Dis 2018 Dec 3;18(1):610. Epub 2018 Dec 3.
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
Background: Environmental disinfection with continuously antimicrobial surfaces could offer superior control of surface bioburden. We sought to decide the efficacy of photocatalyst antimicrobial coating in reducing methicillin-resistant Staphylococcus aureus (MRSA) acquisition in high incidence setting.
Methods: We performed prospective cohort study involving patients hospitalized in medical intensive care unit. Read More
BMC Infect Dis 2018 Dec 4;18(1):614. Epub 2018 Dec 4.
Department of Laboratory Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080, Guangdong, China.
Background: Acinetobacter baumannii is a nosocomial pathogen which is reported as a major cause of morbidity and mortality in intensive care units (ICUs). However, there is a lack of analysis focused on multidrug-resistant Acinetobacter baumannii (MDRAB) infection among patients from pediatric intensive care unit (PICU) in China. The aim of this study was to investigate the molecular characterization of MDRAB isolated from PICU. Read More
Bioresour Technol 2018 Oct 23;274:56-64. Epub 2018 Oct 23.
Key Laboratory of Coal Science and Technology, Ministry of Education and Shanxi Province, Taiyuan University of Technology, Taiyuan 030024, Shanxi, China. Electronic address:
A new acid-resistant bacterium Acinetobacter sp. JR1 was isolated, and its feasibility in nitrogen removal was investigated under acidic condition. Results show that JR1 indicated excellent ammonium and nitrate removal abilities with no accumulation of intermediates, and the maximum ammonium and nitrate removal efficiencies were 98. Read More
Avian Pathol 2018 Nov 30:1-29. Epub 2018 Nov 30.
a Department of Veterinary Sciences , University of Torino , Largo Braccini 2, 10095 Grugliasco (Torino) , Italy.
Macrorhabdus ornithogaster is an opportunistic yeast that colonizes the gastric mucosa of many avian species. Until now, no studies have been focused on about the influence of a gastric infection on the balance of the intestinal microbiota of birds. In this study, 44 fecal samples from individual canaries, with and without M. Read More
J Lab Physicians 2018 Oct-Dec;10(4):432-436
Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Antimicrobial resistance is an increasing problem worldwide especially among the surgical site infections (SSIs). SSI is becoming more serious due to hospital-acquired infections/nosocomial infections, which further leads to the overuse of broad-spectrum antibiotics. To investigate the antimicrobial resistance patterns among Gram-negative bacteria in SSI in in- and out-patients the present study was designed. Read More
J Lab Physicians 2018 Oct-Dec;10(4):426-431
Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Introduction: Bloodstream infections (BSIs) can lead to life-threatening sepsis and are globally associated with high morbidity and mortality. Although BSIs require immediate antimicrobial treatment, their prevalence, etiology, and antimicrobial susceptibilities differ from one country to other. There is a dearth of such data from India. Read More
J Lab Physicians 2018 Oct-Dec;10(4):406-409
Division of Trauma Surgery and Critical Care, JPNATC, AIIMS, New Delhi, India.
Introduction: Device-associated infections constitute the majority of health-care infections in Intensive Care Units (ICUs). Trauma patients are more prone to acquire such infections; ventilator-associated pneumonia (VAP) being the most common Health care associated infections (HAI) in ICU has serious implications such as increased morbidity, prolonged hospital stay, and mortality. This study aims to compare the clinicomicrobiological profile of VAP and non-VAP trauma patients at Level I trauma center. Read More
Microbiome 2018 Nov 29;6(1):213. Epub 2018 Nov 29.
Computational and Systems Biology, Genome Institute of Singapore, Singapore, 138672, Singapore.
Background: Even though human sweat is odorless, bacterial growth and decomposition of specific odor precursors in it is believed to give rise to body odor in humans. While mechanisms of odor generation have been widely studied in adults, little is known for teenagers and pre-pubescent children who have distinct sweat composition from immature apocrine and sebaceous glands, but are arguably more susceptible to the social and psychological impact of malodor.
Results: We integrated information from whole microbiome analysis of multiple skin sites (underarm, neck, and head) and multiple time points (1 h and 8 h after bath), analyzing 180 samples in total to perform the largest metagenome-wide association study to date on malodor. Read More
Microb Pathog 2018 Nov 26. Epub 2018 Nov 26.
Institute of Chemistry and Biological Engineering, Department of Biological Technology, University of Science and Technology Beijing, Beijing, 100083, People's Republic of China. Electronic address:
Acinetobacter johnsonii LXL_C1, a cyprodinil degrader, was isolated and purified from cyprodinil-contaminated agricultural soil. Here, we report the complete genome sequence of LXL_C1. The genome comprises one 3,398,706 bp circular chromosome with 41. Read More
PLoS One 2018 29;13(11):e0198050. Epub 2018 Nov 29.
Environmental Science Research Centre (ESRC), Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.
Microbial Enhanced Oil Recovery (MEOR) is a promising strategy to improve recovery of residual oil in reservoirs, which can be performed by promoting specific indigenous microorganisms. In this study, we performed preliminary evaluation of the possibility of conducting MEOR at Mae Soon reservoir, an onshore reservoir in Northern Thailand. The reservoir's physicochemical characteristics, including the characteristics of the wells, the oil-bearing sandstone cores, and the reservoir's produced water, were determined. Read More
J Appl Microbiol 2018 Nov 29. Epub 2018 Nov 29.
Departamento de Física e Ciências Interdiciplinares, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos, São Paulo, Brazil.
Aims: Characterization of the bacterial community composition and functionality and their impact on substrate biodegradation as well as mushroom yield.
Methods And Results: Bacterial diversity, composition, and functionality were accessed by DNA-derived analysis for a sugarcane straw-based substrate composted for either 5, 10 or 15 days. In addition, carbon and nitrogen losses, carbohydrates conversion as well as mushroom yields were measured for the different treatments. Read More
Medicina (Kaunas) 2018 Nov 26;54(6). Epub 2018 Nov 26.
"Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Street, No. 2, 300041 Timișoara, Romania.
Bacterial multidrug resistance is particularly common in Gram-negative bacilli (GNB), with important clinical consequences regarding their spread and treatment options. The aim of this study was to investigate the trend of multidrug-resistant GNB (MDR-GNB) in high-risk hospital departments, between 2000⁻2015, in intervals of five years, with the intention of improving antibiotic therapy policies and optimising preventive and control practices. This is an observational, retrospective study performed in three departments of the most important tertiary healthcare unit in the southwestern part of Romania: the Intensive Care Unit (ICU), the General Surgery Department (GSD), and the Nutrition and Metabolic Diseases Department (NMDD). Read More
Photochem Photobiol 2018 Nov 28. Epub 2018 Nov 28.
Laboratorio de Investigaciones Microbiológicas de Lagunas Andinas (LIMLA), Planta Piloto de Procesos Industriales y Microbiológicos (PROIMI), CCT, CONICET, Tucumán, Argentina.
"High-Altitude Andean Lakes" (HAAL) are pristine environments harboring poly-extremophilic microbes that show combined adaptations to physical and chemical stress such as large daily ambient thermal amplitude, extreme solar radiation levels, intense dryness, alkalinity, high concentrations of arsenic (up to 200 ppm) and dissolved salts. In this work, we compared the UV resistance profiles, pigment content and photoreactivation abilities of three UV-resistant bacteria isolated from distinct niches from HAAL's: i.e. Read More
Can J Microbiol 2018 Nov 28. Epub 2018 Nov 28.
University of Manitoba, Biosystems Engineering , E2-376 EITC , Winnipeg, Manitoba, Canada , R3T 5V6 ;
We have characterized the ability of eight bacterial strains to utilize powdered low-density polyethylene (LDPE) plastic (un-treated and without any additives) as a sole carbon source. Cell mass production on LDPE containing medium after 21 days of incubation varied between 0.083 ± 0. Read More
Iran J Basic Med Sci 2018 Nov;21(11):1100-1108
College of Medicine, AL-Nahrain University, Medical Microbiology Department, Baghdad, Iraq.
Objectives: Phage therapy is a potential alternative treatment for infections caused by , a significant nosocomial pathogen, which has evolved resistance to almost all conventional antimicrobial drugs in poor hygiene and conflicts areas such as Iraq.
Materials And Methods: Bacteriophages were isolated to highly resistant isolates of to form therapeutic phage cocktail, and to extract and evaluate native endolysin activity. Bacterial samples were collected in Al-Imamein Al-kadhimein Medical City Hospital. Read More
Med Sci Monit 2018 Nov 28;24:8602-8607. Epub 2018 Nov 28.
Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (mainland).
BACKGROUND Antimicrobial resistance of nosocomial pathogens has become a worldwide problem that leads to major healthcare and economic burdens. Regional antimicrobial resistance profiles are needed to inform selection of proper antimicrobial agents. MATERIAL AND METHODS In collaboration with the Hospital Infection Control Office at our hospitals, we analyzed the constitution of nosocomial pathogens and the corresponding drug-resistance profiles. Read More
Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):802-808
State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.
To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens. Read More
Cell Physiol Biochem 2018 Nov 27;51(3):1327-1339. Epub 2018 Nov 27.
Background/aims: Acinetobacter baumannii is an aerobic and Gram-negative bacterial pathogen with high morbidity and mortality. It remains a serious public health problem arising from its multidrug-resistant and extensive antibiotic resistance spectrum.
Methods: In the present study, iTRAQ coupled with 2D LC-MS/MS was used to evaluate the proteome in standard Acinetobacter baumannii standard strains and tigecycline-resistant strains. Read More
Health Secur 2018 ;16(S1):S76-S86
Kiersten Kugeler, PhD, MPH, is an Epidemiologist, Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO.
Global health security depends on effective surveillance for infectious diseases. In Uganda, resources are inadequate to support collection and reporting of data necessary for an effective and responsive surveillance system. We used a cross-cutting approach to improve surveillance and laboratory capacity in Uganda by leveraging an existing pediatric inpatient malaria sentinel surveillance system to collect data on expanded causes of illness, facilitate development of real-time surveillance, and provide data on antimicrobial resistance. Read More
Antimicrob Resist Infect Control 2018 21;7:140. Epub 2018 Nov 21.
5McGill University, Montreal, QC Canada.
Background: The standard epidemiologic investigation of outbreaks typically relies on spatiotemporal data and pulsed-field gel electrophoresis (PFGE), but whole genome sequencing (WGS) is becoming increasingly used. This investigation aimed to characterize a carbapenemase-producing (CPAb) nosocomial outbreak using WGS compared to a standard outbreak investigation.
Methods: The CPAb outbreak occurred in a single center between 2012 and 2014. Read More
Antimicrob Resist Infect Control 2018 19;7:137. Epub 2018 Nov 19.
2State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Medicine School, Zhejiang University, 79 Qingchun Road, Hangzhou, China.
Background: This study aimed to investigate the relationship between the rate of carbapenem-resistant Gram-negative bacteria and antibiotic consumption intensity in 153 tertiary hospitals from China in 2014.
Methods: A retrospective study using national surveillance data from 2014 was conducted. Data on the annual consumption of each antibiotic, as well as the rate of carbapenem-resistant Gram-negative bacteria, were collected from each participating hospital, and the correlation between antibiotic consumption and carbapenem- resistant rate was analyzed. Read More
Antimicrob Agents Chemother 2018 Dec 26;62(12). Epub 2018 Nov 26.
Biological Defense Research Directorate, Naval Medical Research Center, Frederick, Maryland, USA.
J Bacteriol 2018 Nov 26. Epub 2018 Nov 26.
Department of Chemistry, State University of New York, College of Environmental Science and Forestry, Syracuse, New York, USA
Dimethylsulfide (DMS) is a volatile sulfur compound produced mainly from the degradation of dimethylsulfoniopropionate (DMSP) in marine environments. DMS undergoes oxidation to form dimethylsulfoxide (DMSO), dimethylsulfone (DMSO) and methanesulfonate (MSA), all of which occur in terrestrial environments and are accessible for consumption by various microorganisms. The purpose of the current study was to determine how the enhancer-binding proteins SfnR1 and SfnR2 contribute to the utilization of DMS and its derivatives in PAO1. Read More
J Glob Antimicrob Resist 2018 Nov 23. Epub 2018 Nov 23.
Division of Pulmonology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
Objectives: We aimed to confirm the synergistic effects of colistin and rifampin combination therapy compared to colistin monotherapy in pneumonia caused by colistin-resistant Acinetobacter baumannii (CoRAB). In addition, we aimed to assess the utility of the Epsilometer-test (E-test).
Methods: We enrolled 9 subjects who had pneumonia caused by CoRAB from July 20, 2016 to June 21, 2018. Read More