1,802 results match your criteria Achlorhydria


Survival Times of Patients With Menetrier's Disease and Risk of Gastric Cancer.

Clin Gastroenterol Hepatol 2020 Mar 14. Epub 2020 Mar 14.

Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Faculty of Health and Medicine, University of Newcastle, Callaghan, New South Wales, Australia. Electronic address:

Background & Aims: Menetrier's disease is a rare acquired disorder associated with giant gastric folds along with protein-losing enteropathy, hypochlorhydria or achlorhydria, and histologic features of massive foveolar hyperplasia. Little is known about the etiology, clinical features, or epidemiology of this disorder, including risk of gastric cancer. We investigated the outcomes and characteristics of patients with Menetrier's disease, including development of gastric cancer and survival times. Read More

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http://dx.doi.org/10.1016/j.cgh.2020.03.017DOI Listing

Netazepide Inhibits Expression of Pappalysin 2 in Type 1 Gastric Neuroendocrine Tumors.

Cell Mol Gastroenterol Hepatol 2020 Jan 28;10(1):113-132. Epub 2020 Jan 28.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; Liverpool University Hospitals, National Health Service Foundation Trust, Liverpool, United Kingdom. Electronic address:

Background & Aims: In patients with autoimmune atrophic gastritis and achlorhydria, hypergastrinemia is associated with the development of type 1 gastric neuroendocrine tumors (gNETs). Twelve months of treatment with netazepide (YF476), an antagonist of the cholecystokinin B receptor (CCKBR or CCK2R), eradicated some type 1 gNETs in patients. We investigated the mechanisms by which netazepide induced gNET regression using gene expression profiling. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215182PMC
January 2020

[Use of a somatostatin analog to improve a patient's condition and the subsequent diagnosis of pancreatic VIPoma:a case report].

Nihon Shokakibyo Gakkai Zasshi 2020 ;117(1):84-91

Department of Pathology, Fukuyama City Hospital.

A 68-year-old woman with an 11-day history of sudden abdominal pain and severe watery diarrhea was transferred to our hospital due to an exacerbation of renal function despite hydration. After treatment for dehydration and acidemia was provided in our intensive care unit, patient's renal function improved. Contrast-enhanced abdominal computed tomography was finally performed, revealing a hypervascular pancreatic mass with multiple hepatic masses. Read More

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http://dx.doi.org/10.11405/nisshoshi.117.84DOI Listing
January 2020

Dynamic characterization of intestinal metaplasia in the gastric corpus mucosa of Atp4a-deficient mice.

Biosci Rep 2020 Feb;40(2)

Guangzhou University of Chinese Medicine, 232 Waihuan Dong Road, Panyu District, Guangzhou 510405, China.

Parietal cells of the gastric mucosa contain a complex and extensive secretory membrane system that harbors gastric H+, K+-adenosine triphosphatase (ATPase), the enzyme primarily responsible for gastric lumen acidification. Here, we describe the characterization of mice deficient in the H+, K+-ATPase α subunit (Atp4a-/-) to determine the role of this protein in the biosynthesis of this membrane system and the biology of the gastric mucosa. Atp4a-/- mice were produced by gene targeting. Read More

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http://dx.doi.org/10.1042/BSR20181881DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040465PMC
February 2020
2.637 Impact Factor

Influence of opefera on the colon motility of rats in the conditions of prolonged gastric juice hypoacidity.

Wiad Lek 2019 ;72(11 cz 1):2104-2107

Pavlo Tychyna Uman State Pedagogical University, Uman, Ukraine.

Objective: Introduction: Gastric hypohlorhydria is the result of inflammatory process in the intestine caused by dysbiosis. Multiprobiotics significantly improve the colon's motility. Not only probiotics, but also synbiotics are used to eliminate dysbiosis. Read More

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January 2020

The Phylogeny and Biological Function of Gastric Juice-Microbiological Consequences of Removing Gastric Acid.

Int J Mol Sci 2019 Nov 29;20(23). Epub 2019 Nov 29.

Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), 7006 Trondheim, Norway.

Gastric juice is a unique combination of hydrochloric acid (HCl), lipase, and pepsin. Acidic gastric juice is found in all vertebrates, and its main function is to inactivate microorganisms. The phylogenetic preservation of this energy-consuming and, at times, hazardous function (acid-related diseases) reflects its biological importance. Read More

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http://dx.doi.org/10.3390/ijms20236031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928904PMC
November 2019

Marked Hypergastrinemia with G-cell Hyperplasia in Two Autoimmune Gastritis Patients.

Intern Med 2020 Mar 29;59(6):799-803. Epub 2019 Nov 29.

Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Japan.

Gastrin regulates gastric acid secretion, and gastrin secretion itself is regulated by the negative feedback system of gastric acidity. Autoimmune gastritis (AG) is a disease where parietal cells are destroyed, resulting in decreased acid production and an elevated serum gastrin level. We herein report 2 AG cases with marked hypergastrinemia (>5,000 pg/mL). Read More

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http://dx.doi.org/10.2169/internalmedicine.3009-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118375PMC

Successful Treatment of Hypokalemic Rhabdomyolysis Caused by a Pancreatic VIPoma: A Case Report.

Am J Case Rep 2019 Nov 22;20:1723-1727. Epub 2019 Nov 22.

Department of Pathology, Orlando Regional Healthcare, Orlando, FL, USA.

BACKGROUND VIPomas are rare neuroendocrine tumors typically located in the pancreas. The majority of cases autonomously secret vasoactive intestinal polypeptide (VIP), which can result in profuse, refractory, watery diarrhea. The fluid and electrolyte imbalance can progress to dehydration and profound hypokalemia, resulting in the watery diarrhea, hypokalemia, achlorhydria (WDHA) syndrome. Read More

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http://dx.doi.org/10.12659/AJCR.918213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6883984PMC
November 2019

Prevalence of Diagnostic Methods and Treatment Modalities in Vipoma Patients: A Rare Cause of Hormone-Mediated Diarrhea.

Indian J Endocrinol Metab 2019 May-Jun;23(3):318-325

Imam Khomeini Hospital Complex, Faculty of Medicine, National Tehran University of Medical Sciences, Tehran, Iran.

Introduction: VIPoma is a neuroendocrine tumor that secrets vasoactive intestinal peptide and produces a well-defined clinical syndrome characterized by watery diarrhea, hypokalemia, hypochlorhydria and metabolic acidosis. The aim of this study to investigate clinical studies about diagnostic and therapeutic modalities of vipoma patients. In this retrospective study, all patients of vipoma were investigated. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_105_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683692PMC
October 2019
2 Reads

Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger-Ellison Syndrome.

Int J Mol Sci 2019 Oct 16;20(20). Epub 2019 Oct 16.

Digestive Diseases Branch, NIDDK, NIH, Bethesda, MD 20892-1804, USA.

The use of proton pump inhibitors (PPIs) over the last 30 years has rapidly increased both in the United States and worldwide. PPIs are not only very widely used both for approved indications (peptic ulcer disease, gastroesophageal reflux disease (GERD), Helicobacter pylori eradication regimens, stress ulcer prevention), but are also one of the most frequently off-label used drugs (25-70% of total). An increasing number of patients with moderate to advanced gastroesophageal reflux disease are remaining on PPI indefinitely. Read More

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http://dx.doi.org/10.3390/ijms20205128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829234PMC
October 2019
1 Read

[A Case of WDHA Water Diarrhea Hypokalemia Achlorhydria Syndrome that Developed after Multimodal Therapy for Retroperitoneal Paraganglioma].

Hinyokika Kiyo 2019 Jul;65(7):277-282

The Department of Urology, Hokkaido University Hospital.

A 45-year-old woman visited a local clinic with left-flank abdominal pain. Abdominal computed tomography (CT) revealed a tumor 20 cm in diameter in the left adrenal gland. She was referred to our hospital for further treatment. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_6_277DOI Listing
July 2019
5 Reads

A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours.

Gastric Cancer 2020 01 27;23(1):52-63. Epub 2019 Jun 27.

Human Genetics Group, Spanish National Cancer Research Center (CNIO), Melchor Fernández Almagro, 3, 28029, Madrid, Spain.

Background: Type I gastric neuroendocrine tumors (gNETs) arise from hypergastrinemia in patients with autoimmune chronic atrophic gastritis. According to the classical model, the gastric H+/K+ ATPase was the causative autoantigen recognized by CD4+ T cells in chronic autoimmune scenario that secretes IL-17 and correlates with parietal cell (PC) atrophy, which drives to gastric achlorhydria and increases the risk for gastric neoplasms. However, the mechanism by which the inflammatory response correlates with PC atrophy is not clearly defined. Read More

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http://dx.doi.org/10.1007/s10120-019-00982-4DOI Listing
January 2020
7 Reads

Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified.

World J Gastroenterol 2019 Jun;25(22):2706-2719

Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University of Rome, Rome 00161, Italy.

Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the treatment of several acid-related disorders. PPIs are generally well tolerated but, through the long-term reduction of gastric acid secretion, can increase the risk of an imbalance in gut microbiota composition (. Read More

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https://www.wjgnet.com/1007-9327/full/v25/i22/2706.htm
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http://dx.doi.org/10.3748/wjg.v25.i22.2706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580352PMC
June 2019
3 Reads

Somatostatinoma Presented as Double-Duct Sign.

Case Rep Gastrointest Med 2019 9;2019:9506405. Epub 2019 May 9.

Division of Gastroenterology, Providence-Providence Park Hospital and Medical Center, Michigan State University/College of Human Medicine, Southfield, Michigan, USA.

Somatostatinoma is a rare neuroendocrine tumor with an incidence rate of 1 in 40 million people. It presents mostly as asymptomatic tumor diagnosed incidentally on imaging or surgery when evaluating or treating possible causes of abdominal pain. It also can present with vague symptoms, or as a clinical triad of glucose intolerance, steatorrhea, and achlorhydria. Read More

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http://dx.doi.org/10.1155/2019/9506405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6532322PMC
May 2019
18 Reads

HIV related hypochlorhydria does not appear to respond to anti-retroviral therapy in Zambian adults: a case control study.

Pan Afr Med J 2018 22;31:128. Epub 2018 Oct 22.

Tropical Gastroenterology & Nutrition Group, Department of Internal Medicine, University of Zambia School of Medicine, Nationalist Road, Lusaka, Zambia.

Introduction: Human Immunodeficiency Virus (HIV) infection is associated with hypochlorhydria but the mechanism is unknown. The objective of this study was to determine effects of anti-retroviral therapy (ART) on gastric physiology as measured by validated markers.

Methods: We studied HIV infected individuals who were either ART-naïve or on treatment with undetectable viral loads. Read More

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http://www.panafrican-med-journal.com/content/article/31/128
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http://dx.doi.org/10.11604/pamj.2018.31.128.11850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462371PMC
May 2019
26 Reads

Gastric Neuroendocrine Tumors (Carcinoids).

Curr Gastroenterol Rep 2019 Mar 12;21(4):13. Epub 2019 Mar 12.

Division of Gastroenterology and Hepatology, Hospital of the University of Pennsylvania, Perelman School of Medicine, 3400 Civic Center Boulevard, Philadelphia, PA, 19104, USA.

Purpose Of Review: The diagnosis of gastric neuroendocrine tumors (NETs) is being made with increased frequency likely as a result of more upper endoscopies being done for unrelated reasons. It is therefore vital that gastroenterologists become familiar with the basic work-up and management of patients found to have these tumors. This review describes the classification, pathophysiology, clinical characteristics, and treatment options of the different gastric NETs. Read More

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http://dx.doi.org/10.1007/s11894-019-0684-7DOI Listing
March 2019
5 Reads

Subacute Combined Degeneration, Pernicious Anemia and Gastric Neuroendocrine Tumor Occured Simultaneously Caused by Autoimmune Gastritis.

Front Neurosci 2019 25;13. Epub 2019 Jan 25.

Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.

Subacute combined degeneration (SCD) is a relatively rare myelopathy mainly caused by vitamin B (VitB12) deficiency. There are many causes contributing to VitB12 deficiency. Autoimmune gastritis might lead to severe VitB12 malabsorption and in its advanced stage pernicious anemia (PA) may occur. Read More

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http://dx.doi.org/10.3389/fnins.2019.00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355687PMC
January 2019
15 Reads

The changing face of chronic autoimmune atrophic gastritis: an updated comprehensive perspective.

Autoimmun Rev 2019 Mar 11;18(3):215-222. Epub 2019 Jan 11.

Division of Gastroenterology and Center for Autoimmune Liver Diseases, ASST San Gerardo Hospital, Department of Medicine and Surgery, University of Milan Bicocca, Monza, Italy.

Chronic autoimmune atrophic gastritis (CAAG) is an organ-specific autoimmune disease, which affects the corpus-fundus gastric mucosa. Although it has been described for several years, the real pathophysiological mechanisms, the natural history and the possible neoplastic complications are not completely known. Atrophy of the gastric mucosa is the endpoint of the chronic processes, with the loss of glandular cells and their replacement by intestinal-type epithelium, pyloric-type glands, and fibrous tissue. Read More

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http://dx.doi.org/10.1016/j.autrev.2018.08.011DOI Listing
March 2019
18 Reads

Clinical manifestations of chronic atrophic gastritis.

Acta Biomed 2018 12 17;89(8-S):88-92. Epub 2018 Dec 17.

Endoscopy Unit, Departement of Surgery, ULSS7-Pedemontana, Santorso Hospital, Santorso (VI), Italy.

Although the actual prevalence of chronic atrophic gastritis is unknown and it is probable that this entity goes largely underdiagnosed, patients in whom diagnosis is established usually present advanced stages of disease. Destruction of parietal cells, either autoimmune-driven or as a consequence of Helicobacter pylori infection, determines reduction or abolition of acid secretion. Hypo/achloridia causes an increase in serum gastrin levels, with an increased risk of the development of neuroendocrine tumors. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502219PMC
December 2018
17 Reads

Non-invasive method for the assessment of gastric acid secretion.

Acta Biomed 2018 12 17;89(8-S):53-57. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Methods for the measure of gastric acid secretion include invasive and non-invasive tests. The gold-standard to measure the acid output is the collection of gastric after in basal condition (Basal Acid Output, B.A. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6502207PMC
December 2018
3 Reads

Iron deficiency workup reveals high incidence of autoimmune gastritis with parietal cell antibody as reliable screening test.

Semin Hematol 2018 10 7;55(4):256-261. Epub 2018 Aug 7.

Division of Gastroenterology and Hepatology, Medical University of Vienna, Austria; Loha for life, Center of Excellence for Iron Deficiency, Vienna, Austria. Electronic address:

Iron deficiency (ID) workup is a common challenge for gastrointestinal endoscopy. In premenopausal women current guidelines recommend serologic evaluation of coeliac disease only. Here we systematically tested serologic screening for autoimmune gastritis (AIG) in a large cohort of patients with ID. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00371963183005
Publisher Site
http://dx.doi.org/10.1053/j.seminhematol.2018.07.003DOI Listing
October 2018
39 Reads

Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):862-868

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i14.862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264997PMC
November 2018
12 Reads

Relevance of vitamin D deficiency in patients with chronic autoimmune atrophic gastritis: a prospective study.

BMC Gastroenterol 2018 Nov 8;18(1):172. Epub 2018 Nov 8.

Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Chronic autoimmune atrophic gastritis (CAAG) is an autoimmune disease characterized by hypo/achlorhydria. A role of CAAG in the pathogenesis of nutritional deficiencies has been reported, therefore we hypothesized a possible association between CAAG and 25-OH-Vitamin D [25(OH)D] deficiency. Aim of the present study is to evaluate the prevalence of 25(OH)D deficiency in CAAG patients. Read More

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https://bmcgastroenterol.biomedcentral.com/articles/10.1186/
Publisher Site
http://dx.doi.org/10.1186/s12876-018-0901-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225568PMC
November 2018
21 Reads

Pancreatic VIPomas from China: Case reports and literature review.

Pancreatology 2019 Jan 26;19(1):44-49. Epub 2018 Oct 26.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) are rare neuroendocrine tumors that often present as watery diarrhea, hypokalemia, and achlorhydria or hypochlorhydria. In this study, we present our institutional experience of diagnosis and treatment of VIPomas, along with a review of the Chinese literature since 1980. Patient #1, diagnosed in 1984 and with intact clinical records, shows the natural history of this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183070
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http://dx.doi.org/10.1016/j.pan.2018.10.007DOI Listing
January 2019
31 Reads

Conventional Treatment of Hypoparathyroidism.

Endocrinol Metab Clin North Am 2018 12;47(4):889-900

Endocrine Research Unit, Department of Medicine, San Francisco Department of Veterans Affairs Medical Center, University of California, San Francisco, 111N, 1700 Owens Street, 3rd Floor Room 369, San Francisco, CA 94158, USA. Electronic address:

Conventional therapy of hypoparathyroidism consists of oral calcium and either activated vitamin D or vitamin D supplements at varying doses. Although adjusting dosing of calcium and/or activated vitamin D or vitamin D itself, the serum calcium should be obtained weekly or monthly depending on the clinical situation. Calcium supplementation in hypoparathyroidism usually consists of calcium carbonate because it is 40% elemental calcium by weight. Read More

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http://dx.doi.org/10.1016/j.ecl.2018.07.012DOI Listing
December 2018
9 Reads

Chronic Atrophic Gastritis: A Review.

J Environ Pathol Toxicol Oncol 2018 ;37(3):241-259

Department of Gastrointestinal Colorectal, and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.

Chronic atrophic gastritis is a generally asymptomatic condition of great importance because it develops into gastric cancer in a number of patients. It is described as an atrophy of the gastric mucosa. There are two types of atrophic gastritis: a gastric body predominant type in patients with infection of Helicobacter pylori, and an autoimmune type, limited to the gastric body and fundus. Read More

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http://dx.doi.org/10.1615/JEnvironPatholToxicolOncol.2018026839DOI Listing
October 2018
51 Reads

Physiologically based pharmacokinetic modelling to guide drug delivery in older people.

Adv Drug Deliv Rev 2018 10 4;135:85-96. Epub 2018 Sep 4.

Simcyp Ltd (a Certara company), Blades Enterprise Centre, John Street, Sheffield, UK; Centre for Applied Pharmacokinetic Research (CAPKR), University of Manchester, Manchester, UK.

Older patients are generally not included in Phase 1 clinical trials despite being the population group who use the largest number of prescription medicines. Physiologically based pharmacokinetic (PBPK) modelling provides an understanding of the absorption and disposition of drugs in older patients. In this review, PBPK models used for the prediction of absorption and exposure of drugs after parenteral, oral and transdermal administration are discussed. Read More

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http://dx.doi.org/10.1016/j.addr.2018.08.013DOI Listing
October 2018
9 Reads
15.038 Impact Factor

Mucolipidosis type IV in a child.

J AAPOS 2018 Dec 16;22(6):469-471. Epub 2018 Aug 16.

Department of Ophthalmology, Centre hospitalier universitaire Sainte-Justine, Montréal. Electronic address:

Mucolipidosis type IV is a rare autosomal recessive lysosomal storage disorder with psychomotor developmental delay, visual impairment, and achlorhydria. A mutation in the MCOLN1 gene causes an alteration of the protein mucolipin-1 that results in the accumulation of lipids and proteins in cytoplasmic vacuoles derived from lysosomes. Visual impairment results mainly from corneal clouding and retinal degeneration. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.04.011DOI Listing
December 2018
17 Reads

Diagnostic accuracy of a pH stick, modified to detect gastric lipase, to confirm the correct placement of nasogastric tubes.

BMJ Open Gastroenterol 2018 31;5(1):e000218. Epub 2018 Jul 31.

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Objective: The correct placement of a nasogastric feeding tube is usually confirmed by establishing that an aspirate is acidic using a pH stick. However, antacid medication and achlorhydria can cause false negative pH tests that may delay feeding and increase resource use. The purpose of this study was to evaluate a modified pH stick designed to detect gastric lipase and therefore reduce false negative tests. Read More

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http://bmjopengastro.bmj.com/lookup/doi/10.1136/bmjgast-2018
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http://dx.doi.org/10.1136/bmjgast-2018-000218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089299PMC
July 2018
50 Reads

High incidence of autoimmune gastritis in patients misdiagnosed with two or more failures of H. pylori eradication.

Aliment Pharmacol Ther 2018 08 19;48(3):370-377. Epub 2018 Jun 19.

First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.

Background: Although autoimmune gastritis (AIG) is generally considered relatively rare, we frequently encounter AIG among patients at to our hospital who have experienced at least two episodes of Helicobacter pylori eradication failure.

Aims: We investigated the incidence of AIG in consecutive patients who consulted our department for H. pylori eradication with reference to eradication history. Read More

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http://dx.doi.org/10.1111/apt.14849DOI Listing
August 2018
29 Reads

A case of Metaplastic atrophic gastritis in immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) syndrome.

BMC Pediatr 2018 06 15;18(1):191. Epub 2018 Jun 15.

Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background: Autoimmune metaplastic atrophic gastritis is a chronic progressive inflammatory condition. The clinical spectrum includes pernicious anemia, atrophic gastritis, antibodies to parietal cell antigens and intrinsic factor, achlorhydria, hypergastrinemia and carcinoma. It is rare in paediatric cohorts. Read More

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http://dx.doi.org/10.1186/s12887-018-1169-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002972PMC
June 2018
24 Reads

Physiologically Based Absorption Modeling of Salts of Weak Bases Based on Data in Hypochlorhydric and Achlorhydric Biorelevant Media.

AAPS PharmSciTech 2018 Oct 5;19(7):2851-2858. Epub 2018 Jun 5.

Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis, 15784, Zografou, Greece.

Physiologically based absorption modeling has been attracting increased attention to study the interactions of weakly basic drug compounds with acid-reducing agents like proton-pump inhibitors and H2 blockers. Recently, standardized gastric and intestinal biorelevant media to simulate the achlorhydric and hypochlorhydric stomach were proposed and solubility and dissolution data for two model compounds were generated. In the current manuscript, for the first time, we report the utility of these recently proposed biorelevant media as input into physiologically based absorption modeling. Read More

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http://dx.doi.org/10.1208/s12249-018-1059-3DOI Listing
October 2018
64 Reads

Amorphous solid dispersions of carvedilol along with pH-modifiers improved pharmacokinetic properties under hypochlorhydoria.

Biopharm Drug Dispos 2018 Apr;39(4):232-242

Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.

Carvedilol (CAR) belongs to biopharmaceutics classification system class-II drugs, with poor aqueous solubility and pH-dependent solubility. The present study aimed to develop a novel amorphous solid dispersion (ASD) of CAR with acidic counter ions for pH modifications in microenvironment to improve the pharmacokinetic properties under hypochlorhydric conditions. CAR-ASD was prepared by freeze-drying in combination with counter ions and hydroxypropyl cellulose, and their physicochemical properties including dissolution behavior, storage stability, and photostability were characterized. Read More

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http://dx.doi.org/10.1002/bdd.2129DOI Listing
April 2018
25 Reads

HIGH-RISK GASTRIC PATHOLOGY AND PREVALENT AUTOIMMUNE DISEASES IN PATIENTS WITH PERNICIOUS ANEMIA.

Endocr Pract 2017 Nov;23(11):1297-1303

Objective: Pernicious anemia (PA) develops from atrophic gastritis due to autoimmune destruction of parietal cells and results in achlorhydria, vitamin B12 and iron deficiencies, anemia, neurologic deficits, and premalignant and malignant stomach lesions. We report the presentation, diagnosis and gastric complications of PA in patients from an endocrinology practice.

Methods: Thirty-four patients (31 female, 3 male) with PA who underwent esophagogastroduodenoscopy (EGD) or gastrectomy were identified. Read More

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http://dx.doi.org/10.4158/EP-2017-0056DOI Listing
November 2017
34 Reads

The risk of infection in patients with pernicious anaemia: a retrospective cohort study using primary care database.

United European Gastroenterol J 2017 Nov 21;5(7):959-966. Epub 2017 Feb 21.

Department of Epidemiology and Public Health, University of Nottingham, Nottingham, UK.

Background: Studies have found an association between proton pump inhibitor (PPI) use and infection. The purpose of this study was to determine whether the mechanism by which PPIs induce an increased risk of infection is supported by the same mechanism acting in another cause of achlorhydria, pernicious anaemia.

Methods: Using a database of anonymised primary care records between 1990 and 2013, we selected exposed patients with a diagnosis of pernicious anaemia treated with vitamin B12 therapy. Read More

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http://dx.doi.org/10.1177/2050640617695697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5676549PMC
November 2017
39 Reads

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.

PLoS Pathog 2017 Nov 2;13(11):e1006653. Epub 2017 Nov 2.

Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UNITED KINGDOM.

Several conditions associated with reduced gastric acid secretion confer an altered risk of developing a gastric malignancy. Helicobacter pylori-induced atrophic gastritis predisposes to gastric adenocarcinoma, autoimmune atrophic gastritis is a precursor of type I gastric neuroendocrine tumours, whereas proton pump inhibitor (PPI) use does not affect stomach cancer risk. We hypothesised that each of these conditions was associated with specific alterations in the gastric microbiota and that this influenced subsequent tumour risk. Read More

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http://dx.doi.org/10.1371/journal.ppat.1006653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5667734PMC
November 2017
42 Reads

High prevalence of gastric intestinal metaplasia detected by confocal laser endomicroscopy in Zambian adults.

PLoS One 2017 8;12(9):e0184272. Epub 2017 Sep 8.

Tropical Gastroenterology & Nutrition group, Department of Internal Medicine, University of Zambia School of Medicine, Lusaka, Zambia.

Background: Confocal laser endomicroscopy (CLE) may increase the detection of gastric premalignant lesions, and facilitate targeted biopsies for histology. The study aim was to analyse premalignant lesions in Zambian adults using CLE.

Methods: Using CLE and histology we analysed the antral mucosa for gastric premalignant lesions in asymptomatic adults living with HIV and in HIV seronegative adults. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0184272PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590914PMC
October 2017
26 Reads

Biorelevant Dissolution Models for a Weak Base To Facilitate Formulation Development and Overcome Reduced Bioavailability Caused by Hypochlordyria or Achlorhydria.

Mol Pharm 2017 10 8;14(10):3577-3587. Epub 2017 Sep 8.

Pfizer Korea, Pfizer Tower, 110, Toegye-ro, Jung-gu, Seoul 04631, Korea.

In this study, two dissolution models were developed to achieve in vitro-in vivo relationship for immediate release formulations of Compound-A, a poorly soluble weak base with pH-dependent solubility and low bioavailability in hypochlorhydric and achlorhydric patients. The dissolution models were designed to approximate the hypo-/achlorhydric and normal fasted stomach conditions after a glass of water was ingested with the drug. The dissolution data from the two models were predictive of the relative in vivo bioavailability of various formulations under the same gastric condition, hypo-/achlorhydric or normal. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00593DOI Listing
October 2017
49 Reads

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation-dependent effect of achlorhydria.

Eur J Pharm Sci 2017 Nov 1;109:111-120. Epub 2017 Aug 1.

Centre for Applied Pharmacokinetic Research, Division of Pharmacy & Optometry, University of Manchester, Manchester, UK; Simcyp Limited (A Certara Company), Sheffield, UK.

Majority of bioequivalence studies are conducted in healthy volunteers. It has been argued that bioequivalence may not necessarily hold true in relevant patient populations due to a variety of reasons which affect one formulation more than the other for instance in achlorhydric patients where elevated gastric pH may lead to differential effects on formulations which are pH-sensitive with respect to release or dissolution. We therefore examined achlorhydria-related disparity in bioequivalence of levothyroxine and nifedipine formulations using virtual bioequivalence within a physiologically-based pharmacokinetic (PBPK) modelling framework. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987173043
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http://dx.doi.org/10.1016/j.ejps.2017.07.035DOI Listing
November 2017
81 Reads

A Case of Severe Iron Deficiency Anemia Associated with Long-Term Proton Pump Inhibitor Use.

Curr Ther Res Clin Exp 2017;84:1-3. Epub 2017 Jan 21.

Department of Internal Medicine, Boonshoft School of Medicine, Wright State University, Dayton, Ohio.

The use of proton pump inhibitors (PPIs) in the treatment of gastrointestinal diseases has evolved over recent years. Initially intended for short-term use, PPIs are increasingly being used, often inappropriately, as long-term maintenance medications. The mechanism of action of PPIs is suppression of gastric basal and stimulated acid secretion by inhibiting the parietal cell H/K ATP pump with a resultant increase in gastric pH and hypo- or achlorhydria. Read More

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http://dx.doi.org/10.1016/j.curtheres.2017.01.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522969PMC
January 2017
59 Reads

Verner-Morrison syndrome. Literature review.

Rom J Morphol Embryol 2017 ;58(2):371-376

Department of Pediatric Surgery, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Department of Neonatology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;

Chronic diarrhea in infants is a common condition for addressability to pediatric gastroenterologists. The causes are multiple and the delay in reaching the final diagnosis can lead to complications in the general condition of the child. The purpose of this review is to present the bio-clinical and histogenetic particularities of a rare clinical entity, characterized by tumoral causes of chronic diarrhea. Read More

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April 2018
72 Reads

Hunger and microbiology: is a low gastric acid-induced bacterial overgrowth in the small intestine a contributor to malnutrition in developing countries?

Microb Biotechnol 2017 09 17;10(5):1025-1030. Epub 2017 Jul 17.

Nutrition and Health Institute, Gut Ecosystem Department, Host- Microbe Interaction Group, Nestlé Research Centre, CH-1000, Lausanne 26, Switzerland.

Underproduction of hydrochloric acid into the stomach is frequently encountered in subjects from developing countries. We explore the hypothesis that hypochlorhydria compromises the gastric barrier and favours bacterial overgrowth in the proximal parts of the small intestine where nutrient absorption takes place. Food calories are thus deviated into bacterial metabolism. Read More

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http://dx.doi.org/10.1111/1751-7915.12780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609274PMC
September 2017
25 Reads

TRPML1: The Caretaker of the lysosome.

Cell Calcium 2018 01 24;69:112-121. Epub 2017 Jun 24.

Telethon Institute of Genetics and Medicine (TIGEM), Via Campi Flegrei 34, 80078 Pozzuoli ,NA, Italy. Electronic address:

Efficient functioning of lysosome is necessary to ensure the correct performance of a variety of intracellular processes such as degradation of cargoes coming from the endocytic and autophagic pathways, recycling of organelles, and signaling mechanisms involved in cellular adaptation to nutrient availability. Mutations in lysosomal genes lead to more than 50 lysosomal storage disorders (LSDs). Among them, mutations in the gene encoding TRPML1 (MCOLN1) cause Mucolipidosis type IV (MLIV), a recessive LSD characterized by neurodegeneration, psychomotor retardation, ophthalmologic defects and achlorhydria. Read More

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http://dx.doi.org/10.1016/j.ceca.2017.06.006DOI Listing
January 2018
26 Reads

A cumulative effect involving malfunction of the PTH1R and ATP4A genes explains a familial gastric neuroendocrine tumor with hypothyroidism and arthritis.

Gastric Cancer 2017 Nov 4;20(6):998-1003. Epub 2017 May 4.

Human Genetics Group, Spanish National Cancer Research Center (CNIO), Melchor Fernández Almagro 3, 28029, Madrid, Spain.

Background: Type I gastric neuroendocrine tumors (gNETs) classically arise because of hypergastrinemia and involve destruction of parietal cells, which are responsible for gastric acid secretion through the ATP4A proton pump and for intrinsic factor production.

Methods: By whole exome sequencing, we studied a family with three members with gNETs plus hypothyroidism and rheumatoid arthritis to uncover their genetic origin.

Results: A heterozygous missense mutation in the ATP4A gene was identified. Read More

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http://dx.doi.org/10.1007/s10120-017-0723-8DOI Listing
November 2017
80 Reads

Autoimmune gastritis: relationships with anemia and Helicobacter pylori status.

Scand J Gastroenterol 2017 Jun - Jul;52(6-7):674-677. Epub 2017 Feb 17.

h Gastroenterology and Hepatology Section, Department of Medicine , University of Perugia School of Medicine , Perugia , Italy.

Background: Autoimmune gastritis (AIG) is a gastric pathologic condition affecting the mucosa of the fundus and the body and eventually leading to hypo-achlorhydria.

Aims: We report our clinical and pathological experience with AIG.

Methods: Data from patients with a diagnosis of AIG seen in the period January 2002-December 2012 were retrieved. Read More

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http://dx.doi.org/10.1080/00365521.2017.1288758DOI Listing
October 2017
32 Reads

The impact of reduced gastric acid secretion on dissolution of salts of weak bases in the fasted upper gastrointestinal lumen: Data in biorelevant media and in human aspirates.

Eur J Pharm Biopharm 2017 Jun 16;115:94-101. Epub 2017 Feb 16.

Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Zografou, Greece. Electronic address:

Purpose: To propose media for simulating the intragastric environment under reduced gastric acid secretion in the fasted state at three levels of simulation of the gastric environment and evaluate their usefulness in evaluating the intragastric dissolution of salts of weak bases. To evaluate the importance of bicarbonate buffer in biorelevant in vitro dissolution testing when using Level II biorelevant media simulating the environment in the fasted upper small intestine, regardless of gastric acid secretions.

Methods: Media for simulating the hypochlorhydric and achlorhydric conditions in stomach were proposed using phosphates, maleates and bicarbonates buffers. Read More

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http://dx.doi.org/10.1016/j.ejpb.2017.02.009DOI Listing
June 2017
49 Reads