Search Our Scientific Publications & Authors

J Thorac Cardiovasc Surg 2018 Nov 8. Epub 2018 Nov 8.

Department of Cardiac Surgery, Boston Children's Hospital, Boston, Mass; Department of Surgery, Harvard Medical School, Boston, Mass. Electronic address:

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide. Despite the substantial advancement in understanding the molecular mechanisms and management of BC, it remains the leading cause of cancer death in women. One of the main reasons for this obstacle is that we have not been able to find the Achilles heel for the BC as a highly heterogeneous disease. Read More

Tech Coloproctol 2018 Dec 8. Epub 2018 Dec 8.

Department of Surgery, ASS-5 Friuli Venezia Giulia, San Vito al Tagliamento, 33078, Italy.

Background: Laser closure is a novel sphincter-saving technique for the treatment of anal fistula. The aim of this study was to report middle term results of laser treatment without closure of the internal orifice and to identify prognostic factors to improve selection criteria and maximize healing.

Methods: A retrospective observational study was conducted on patients treated with laser for transphinteric anal fistula. Read More

Orthop J Sports Med 2018 Nov 28;6(11):2325967118810772. Epub 2018 Nov 28.

Department of Orthopaedics, New York Presbyterian, Columbia University Medical Center, New York, New York, USA.

Background: The majority of Achilles tendon ruptures are sports related; however, no investigation has examined the impact of surgical repair for complete ruptures on professional soccer players.

Purpose: To examine the return to play, playing time, and performance of professional soccer players following Achilles tendon repair.

Study Design: Cohort study; Level of evidence, 3. Read More

Case Rep Orthop 2018 11;2018:6207024. Epub 2018 Nov 11.

Klinik für Unfall und Wiederherstellungschirurgie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

Avulsion fractures of the calcaneal tuberosity represent a rare injury pattern that is caused by a powerful tension force from the Achilles tendon and is usually seen following minor trauma, especially in elderly patients. The objective of this study is to describe a surgical technique using cerclage wiring through cannulated screws in the treatment of extra- and intra-articular avulsion fractures of the calcaneal tuberosity and to present our results in a small patient's cohort. Through a 5. Read More

J Biomech 2018 Nov 16. Epub 2018 Nov 16.

School of Human Sciences, University of Western Australia, Perth, Australia. Electronic address:

The effectiveness of the plantarflexor muscle group to generate desired plantarflexion moments is modulated by the geometry of the Achilles tendon moment arm (ATMA). Children with cerebral palsy (CP) frequently have reduced plantarflexion function, which is commonly attributed to impaired muscle structure and function, however little attention has been paid to the potential contribution of ATMA geometry. The use of musculoskeletal modelling for the simulation of gait and understanding of gait mechanics, rely on accuracy of ATMA estimates. Read More

Eur J Radiol 2018 Dec 5;109:1-7. Epub 2018 Oct 5.

Department of Ultrasonography, Capital Medical University Affiliated Beijing Anzhen Hospital, 2 Anzhen Road St, Chaoyang District, Beijing, 100029, China.

Objective: To investigate the feasibility of grayscale ultrasound and quantitative shear wave elastography (SWE) for assessing the image features and stiffness of the Achilles tendon in patients with familial hypercholesterolemia (FH) compared with healthy controls.

Methods: A total of 38 Achilles tendons from healthy control participants and 94 from patients with FH were examined with grayscale ultrasound and SWE. Each Achilles tendon examination was performed on 3 different segments (proximal, middle, and distal). Read More

Z Orthop Unfall 2018 Dec 6. Epub 2018 Dec 6.

Zentrum für Sportorthopädie, European SportsCare Network (ESN), Wiesbaden-Nordenstadt.

Background: Reattachment of the distal Achilles tendon to the posterior calcaneus following distal Achilles tendon tears/avulsions or after excision of large posterior heel spurs is a challenging task for the orthopaedic surgeon.

Patients/material And Methods: Between 2005 and the end of 2015, 22 patients who underwent repair/reconstruction of a lesion of the distal Achilles tendon were identified from our electronic records. Calcaneal reinsertions were performed following distal Achilles tendon tears/avulsions (n = 15) or following excision of a large symptomatic posterior heel spur (n = 7). Read More

Acta Bioeng Biomech 2018 ;20(4):77-87

Institute of Bioengineering, Zhejiang Academy of Medical Sciences, Hangzhou, Zhejiang Province, China.

A scaffold knit with natural sericin-free silk fibroin fiber possesses desirable mechanical properties, biocompatibility, ease of fabrication, and slow degradability. However, regenerated silk fibroin degrades faster than natural silk. In this study, natural silk fibroin fiber mesh-like scaffolds were prepared by a weft-knitting method and the pores were filled with sponge-like regenerated silk fibroin-collagen I. Read More

Orthop J Sports Med 2018 Nov 26;6(11):2325967118808238. Epub 2018 Nov 26.

Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University, Providence, Rhode Island, USA.

Background: Achilles tendon (AT) ruptures are one of the most common tendon ruptures, but there have been no studies investigating these injuries in the United States (US) using data representative of the entire US population.

Purpose/hypothesis: The purpose of this study was to determine the incidence and risk factors for AT ruptures in the US. We hypothesized that male sex, older age, and sport participation would increase the risk for AT ruptures. Read More

J Clin Lipidol 2018 Nov 7. Epub 2018 Nov 7.

Department of Medicine, Centre for Heart and Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Achilles tendon xanthoma (ATX) results from tendon thickening and subclinical inflammation triggered by hypercholesterolemia, and is associated with more severe coronary artery disease and a higher risk of cardiovascular events. The ability to detect ATX by clinical examination is limited, and diagnostic imaging, for instance, using ultrasonography or magnetic resonance imagine (MRI), may improve the identification of ATX. However, the accuracy of ultrasound (US) imaging or MRI in identifying ATX in people with familial hypercholesterolemia (FH) has not been systematically reviewed. Read More

PLoS One 2018 5;13(12):e0208175. Epub 2018 Dec 5.

Bern University of Applied Sciences, Department of Health Professions, Division of Physiotherapy, Bern, Switzerland.

Introduction: The translation of the navicular bone is thought to be a representative surrogate measure to assess foot pronation and hence foot function; however, it is not known how it is related to multi-segment foot kinematics.

Methods: Cranio-caudal (NCC) and medio-lateral (NML) navicular translation and multi-segment foot kinematics from the Oxford Foot Model (OFM) were simultaneously assessed during the stance phase of walking in 20 healthy adults. Relationships to forefoot to hindfoot (FFtoHF), hindfoot to tibia (HFtoTBA) and global hindfoot (HFL) motion were explored by cross-correlations at zero phase shift. Read More

J Bone Joint Surg Am 2018 Dec;100(23):2004-2014

Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Background: To our knowledge, there are no reports of the Ponseti method initiated after walking age and with >10 years of follow-up. Our goal was to report the clinical findings and patient-reported outcomes for children with a previously untreated idiopathic clubfoot who were seen when they were between 1 and 5 years old, were treated with the Ponseti method, and had a minimum follow-up of 10 years.

Methods: A retrospective review of medical records was supplemented by a follow-up evaluation of physical findings (alignment and range of motion) and patient-reported outcomes using the Oxford Ankle Foot Questionnaire for Children (OxAFQ-C). Read More

Foot Ankle Spec 2018 Dec 5:1938640018816376. Epub 2018 Dec 5.

Department of Orthopaedics, Miller School of Medicine, University of Miami, Miami, Florida.

Introduction: Obesity is an increasingly common comorbidity that may negatively affect outcomes following orthopaedic surgery. It is valuable to determine whether obese patients are vulnerable for postoperative complications. The purpose of this study was to analyze data from the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) to determine the effect of obesity on surgical treatment of Achilles tendon ruptures. Read More

Musculoskelet Sci Pract 2018 Nov 15;39:67-72. Epub 2018 Nov 15.

Orthopaedic Department, AMBU HB, Swansea, UK.

Background: Achilles tendinopathy is a common pathology that is considered difficult to treat. At a time of austerity in the NHS it is essential to have carefully designed pathways that are monitored in terms of cost and effectiveness. However, a paucity of evidence exists for what the "best value" dedicated "joined up" pathway of care is for this difficult condition. Read More

Psychiatry Clin Neurosci 2018 12;72(12):854-855

Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.

Stem Cells Int 2018 28;2018:2613821. Epub 2018 Oct 28.

Center for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518000, China.

Tendinopathy is prevalent in athletic and many occupational populations; nevertheless, the pathogenesis of tendinopathy remains unclear. Tendon-derived stem cells (TDSCs) were regarded as the key culprit for the development of tendinopathy. However, it is uncertain how TDSCs differentiate into adipocytes, chondrocytes, or osteocytes in the degenerative microenvironment of tendinopathy. Read More

Int J Nanomedicine 2018 8;13:7217-7227. Epub 2018 Nov 8.

Department of Physical and Rehabilitation Medicine, Stem Cell and Regenerative Medicine Institute, Samsung Medical Center, Seoul, Republic of Korea,

Background: Tendon-derived stem cells (TDSCs) are key factors associated with regeneration and healing in tendinopathy. The aim of this study was to investigate the effects of mechanical stiffness and topographic signals on the differentiation of TDSCs depending on age and pathological conditions.

Materials And Methods: We compared TDSCs extracted from normal tendon tissues with TDSCs from tendinopathic Achilles tendon tissues of Sprague Dawley rats in vitro and TDSCs cultured on nanotopographic cues and substrate stiffness to determine how to control the TDSCs. Read More

Curr Top Med Chem 2018 Nov 30. Epub 2018 Nov 30.

Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, NM. United States.

Malaria continues to impinge heavily on mankind, with five continents still under its clasp. Wide spread and rapid emergence of drug resistance in the Plasmodium parasite to current therapies, accentuate the quest for novel drug targets and antimalarial compounds. Plasmodium parasites, maintain a non-photosynthetic relict organelle known as Apicoplast. Read More

Cancer Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan.

Glioblastoma (GBM) is a highly aggressive form of cancer that is resistant to standard therapy with concurrent radiation and temozolomide, two agents that work by inducing DNA damage. An underlying cause of this resistance may be a subpopulation of cancer stem-like cells that display a heightened DNA damage response (DDR). Although this DDR represents an attractive therapeutic target for overcoming the resistance of GBMs to radiotherapy, until now, the cause of this DDR upregulation has not been understood. Read More

J Hum Evol 2018 Nov 26. Epub 2018 Nov 26.

Florida Museum of Natural History, University of Florida, P.O. Box 117800, Gainesville, FL 32611-7800, USA. Electronic address:

Omomyiform primates are among the most basal fossil haplorhines, with the oldest classified in the genus Teilhardina and known contemporaneously from Asia, Europe, and North America during the Paleocene-Eocene Thermal Maximum (PETM) ∼56 mya. Characterization of morphology in this genus has been limited by small sample sizes and fragmentary fossils. A new dental sample (n = 163) of the North American species Teilhardina brandti from PETM strata of the Bighorn Basin, Wyoming, documents previously unknown morphology and variation, prompting the need for a systematic revision of the genus. Read More

BMC Musculoskelet Disord 2018 Nov 30;19(1):426. Epub 2018 Nov 30.

Department of Integrative Medical Biology, Section for Anatomy, Umeå University, Johan Bures väg 12, 901 87, Umeå, Sweden.

Background: Tendon disorders are common and lead to significant disability and pain. Our knowledge of the 'tennis elbow', the 'jumpers knee', and Achilles tendinosis has increased over the years, but changes in denervated tendons is yet to be described in detail. The aim of the present study was to investigate the morphological and biochemical changes in tendon tissue following two weeks of denervation using a unilateral sciatic nerve transection model in rat Achilles tendons. Read More

J Virol 2018 Nov 28. Epub 2018 Nov 28.

Department of Biological Sciences, University of North Carolina at Charlotte, Charlotte North Carolina, USA

Vesicular stomatitis virus (VSV, a rhabdovirus) and its variant VSV-ΔM51 are widely used model systems to study mechanisms of virus-host interactions. Here, we investigated how cell cycle affects replication of these viruses using an array of cell lines with different levels of impairment of antiviral signaling, and a panel of chemical compounds arresting cell cycle at different phases. We observed that all compounds inducing cell cycle arrest in G2/M phase strongly enhanced replication of VSV-ΔM51 in cells with functional antiviral signaling. Read More

J Anat 2018 Nov 28. Epub 2018 Nov 28.

Department of Biomedical Engineering, University of Delaware, Newark, USA.

Rodent tendons are widely used to study human pathologies such as tendinopathy and repair, and to address fundamental physiological questions about development, growth, and remodeling. However, how the gross morphology and multi-scale hierarchical structure of rat tendons, such as the tail, plantaris, and Achilles tendons, compare with that of human tendons are unknown. In addition, there remains disagreement about terminology and definitions. Read More

Am J Orthop (Belle Mead NJ) 2018 Oct;47(10)

The Orlin & Cohen Orthopedic Group, 45 Crossways Park Drive, Woodbury, NY 11797, USA. Email:

In this study, we determine the in vivo effects of injecting sub-populations of leukocytes into normal rat Achilles tendons via a controlled laboratory study. Allogenic monocytes, granulocytes, or plasma were injected into 24 healthy rat Achilles tendons. Treated and contralateral un-treated control tendons then assessed for cellularity, histologic morphology, and vascularity after 7 and 14 days. Read More

J Bone Joint Surg Am 2018 Nov;100(22):1969-1981

Dipartimento di Scienze Biomediche e Neuromotorie (DIBINEM), University of Bologna, Bologna, Italy.

Background: There is no consensus on the optimal technique for repairing an acute Achilles tendon rupture. The purpose of this meta-analysis was to compare the complications, subjective outcomes, and functional results between minimally invasive surgery and open repair of an Achilles tendon rupture.

Methods: A systematic literature search of MEDLINE/PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), EBSCOhost, and ClinicalTrials. Read More

Psychol Belg 2018 Jul 26;58(1):166-171. Epub 2018 Jul 26.

Faculty of Psychology and Educational Sciences, KU Leuven, BE.

This manuscript is part of a special issue to commemorate professor Paul Eelen, who passed away on August 21, 2016. Paul was a clinically oriented scientist, for whom learning principles (Pavlovian or operant) were more than salivary responses and lever presses. His expertise in learning psychology and his enthusiasm to translate this knowledge to clinical practice inspired many inside and outside academia. Read More

J Biomech 2018 Nov 15. Epub 2018 Nov 15.

Kennesaw State University, Georgia Institute of Technology. Electronic address:

Currently, noninvasive cost-effective techniques capable of quantifying non-uniform degradation of tendon's mechanical and structural properties associated with localized tendon injuries are not readily available. This study demonstrates the applicability of a simple surface-wave elastography (SURF-E) method for assessing the stiffness of the Achilles Tendon by measuring the propagation velocity of surface waves along the tendon in a much broader range of values than currently available Ultrasound-based or MRI-based elastography methods do. Results from this study confirm the non-uniform stiffening of the AT during passive ankle dorsiflexions. Read More

J Clin Lipidol 2018 Oct 29. Epub 2018 Oct 29.

Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan; Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

Background: Tendon xanthomas are accumulations of collagen and macrophages, which contain cholesterol esters and a marker of high risk for coronary artery disease (CAD).

Objective: The aim of the article was to clarify whether the presence of Achilles tendon thickening (ATT) was associated with disease severity and plaque vulnerability in patients with CAD.

Methods: A total of 241 consecutive patients who underwent percutaneous coronary intervention and ATT assessment were analyzed. Read More

Eur J Surg Oncol 2018 Nov 15. Epub 2018 Nov 15.

Department of General, Visceral and Thoracic Surgery, University Hospital Hamburg-Eppendorf, Germany.

Several patients' and pathological characteristics in rectal surgery can significantly complicate surgical loco regional tumor clearance. The main factors are obesity, short tumor distance from anal verge, bulky tumors, and narrow pelvis, which have been shown to be associated to poor surgical results in open and laparoscopic approaches. Minimally invasive surgery has the potential to reduce perioperative morbidity with equivalent short- and long-term oncological outcomes compared to conventional open approach. Read More

J Clin Med 2018 Nov 21;7(11). Epub 2018 Nov 21.

Research, Health and Podiatry Unit, Department of Health Sciences, Faculty of Nursing and Podiatry, Universidade da Coruña, 15403 Ferrol, Spain.

Objective: To assess clinical differences in the Achilles tendons of runners with ankle equinus wearing either compressive or standard stockings.

Design: Case⁻control study.

Methods: In this study, we conducted clinical examinations of 98 sportsmen (runners) with equinus, before and after 30 min of running on a treadmill; 49 runners wore compressive stockings and 49 wore standard stockings. Read More

Clin Drug Investig 2018 Nov 21. Epub 2018 Nov 21.

Pharmacovigilance and Epidemiology Department, European Medicines Agency, London, UK.

Background And Objective: Tendon rupture can result from fluoroquinolone exposure. The objective of this study was to quantify relative and absolute risk and determine how risk is affected by timing of exposure.

Methods: The UK Health Improvement Network primary care database was used to perform a nested case-control study measuring the association between fluoroquinolone exposure and tendon rupture. Read More

Bone Joint Res 2018 Oct 3;7(10):561-569. Epub 2018 Nov 3.

Department of Orthopedic Surgery, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, Beijing Key Lab of Regenerative Medicine in Orthopedics, Chinese PLA General Hospital, Beijing, China.

Objectives: The incidence of acute Achilles tendon rupture appears to be increasing. The aim of this study was to summarize various therapies for acute Achilles tendon rupture and discuss their relative merits.

Methods: A PubMed search about the management of acute Achilles tendon rupture was performed. Read More

Sci Rep 2018 Nov 20;8(1):17064. Epub 2018 Nov 20.

Luoyang Orthopedic Hospital of Henan Province, Orthopedic Hospital of Henan Province, Luoyang, China.

The purposes of this study were to compare Young's modulus values determined by shear wave ultrasound elastography (SWUE) with stiffness index obtained using a hand-held MyotonPRO device on the resting stiffness of gastrocnemius muscle belly and Achilles tendon; and to examine the test-retest reliability of those stiffness measurement using hand-held MyotonPRO. Twenty healthy volunteers participated in the study. The measurement values of muscle and tendon was determined in dominant legs. Read More

MBio 2018 Nov 20;9(6). Epub 2018 Nov 20.

Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, California, USA

The genus has at least five members, four of which are known to cause deadly disease in humans. An ideal therapy or a vaccine would protect against all ebolaviruses, but identifying a common weakness in all of them has remained elusive. West et al. Read More

J Clin Lipidol 2018 Oct 24. Epub 2018 Oct 24.

Department of Internal Medicine V (Nephrology, Rheumatology, Hypertensiology, Endocrinolgy, Diabetology), Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany; Mannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, University of Heidelberg, Mannheim, Germany. Electronic address:

A 33-year-old female had suffered from spontaneously recurrent bursitis and tendosynovitis/enthesitis of the patellar and Achilles tendons for about 10 years. The episodes of immobilization increased. Ultrasound imaging of the swollen and painful tendons showed chronic inflammation with neoangiogenesis within the tendons and hypoechoic lesions. Read More

J Bone Miner Res 2018 Nov 20. Epub 2018 Nov 20.

Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Heterotopic ossification is the abnormal formation of mineralized bone in skin, muscle, tendon, or other soft tissues. Tendon ossification often occurs from acute tendon injury or chronic tendon degeneration, of which current treatment relies heavily on surgical removal of the ectopic bony tissues. Unfortunately, surgery creates additional trauma, which often causes recurrence of heterotopic ossification. Read More

NMR Biomed 2018 Nov 20:e4034. Epub 2018 Nov 20.

Department of Radiology, University of California, San Diego, CA, USA.

Entheses are regions where tendons and ligaments attach to bone, and are the primary target in seronegative and other diseases of the musculoskeletal (MSK) system. MRI has been widely used for visualizing features of inflammatory and degenerative MSK disease; however, normal tendons and entheses have short transverse relaxation times (T ), and show little or no signal with conventional clinical MRI pulse sequences, making it difficult to investigate their MR properties. In this study we examined the normal MR morphology of the cadaveric Achilles tendon and enthesis at 3 T using novel three-dimensional ultrashort echo time (3D UTE) Cones sequences, and at 11. Read More

Child Neurol Open 2018 14;5:2329048X18811452. Epub 2018 Nov 14.

Shriners Hospitals for Children, Jefferson School of Health Professions, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: This pilot study evaluated the outcomes of tendon Achilles lengthening in 12 children (mean age: 11.2 years) with spastic hemiplegia.

Methods: Cerebral Palsy Computer Adaptive Tests, the timed up-and-go, the Gross Motor Function Measure, the Gillette Functional Assessment Questionnaire, and the Pediatric Outcomes Data Collection Instrument were administered at baseline and at 6, 12, and 24 months postsurgery. Read More

Foot Ankle Surg 2018 Nov 5. Epub 2018 Nov 5.

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 North Caroline Street, Baltimore, MD 21287, United States.

Background: Clinical assessment of hindfoot alignment (HA) in adult acquired flatfoot deformity (AAFD) can be challenging and weightbearing (WB) cone beam CT (CBCT) may potentially better demonstrate this three-dimensional (3D) deformity. Therefore, we compared clinical and WB CBCT assessment of HA in patients with AAFD.

Methods: In this prospective study, we included 12 men and 8 women (mean age: 52. Read More

BMC Pulm Med 2018 Nov 19;18(1):170. Epub 2018 Nov 19.

Centre for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.

Background: Non-Tuberculous Mycobacterial-pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requiring prolonged antibiotic therapy. Read More

Eur J Rheumatol 2018 Nov 16:1-5. Epub 2018 Nov 16.

Division of Rheumatology, University of California David Geffen School of Medicine, Los Angeles, USA.

Alkaptonuria (AKU) is a rare autosomal recessive disorder that results from the deficient activity of homogentisate 1,2-dioxygenase and leads to increased levels of homogentisic acid (HGA) and its oxidized product benzoquinone acetic acid (BQA). Both HGA and BQA form polymerized deposits that lead to a bluish-black discoloration of the cartilage as well as degeneration, inflammation, and calcification of the tendons, ligaments, intervertebral discs, and large joints and increased bone resorption. A brittle and fragmented cartilage forms and leads to aberrant loading of the subchondral bone. Read More

Aging Cell 2018 Nov 19:e12875. Epub 2018 Nov 19.

Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

Cellular senescence is a typical tumor-suppressive mechanism that restricts the proliferation of premalignant cells. However, mounting evidence suggests that senescent cells, which also persist in vivo, can promote the incidence of aging-related disorders principally via the senescence-associated secretory phenotype (SASP), among which cancer is particularly devastating. Despite the beneficial effects of the SASP on certain physiological events such as wound healing and tissue repair, more studies have demonstrated that senescent cells can substantially contribute to pathological conditions and accelerate disease exacerbation, particularly cancer resistance, relapse and metastasis. Read More

J Foot Ankle Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore. Electronic address:

The loss of Achilles tendon results in reduced plantar flexion strength; however, in patients who are not fit for major reconstructive surgery, with soft-tissue defects overlying the tendon, Achilles tendon excision is a useful adjunct procedure for wound closure. We report 3 patients with infections around the Achilles tendons needing debridement procedures who underwent Achilles tendon excision for the purpose of wound closure. Local healing was achieved in all patients; all returned to their premorbid ambulatory status, and 2 could perform heel raise. Read More

Clin Podiatr Med Surg 2019 Jan 25;36(1):141-151. Epub 2018 Oct 25.

DeKalb Medical Center, 2701 North Decatur Road, Decatur, GA 30033, USA.

Obese patients are at higher risk for surgical complications and consist of a large portion of podiatric patients. Obese patients are additionally at increased risk of developing specific podiatric conditions, and it is important to be able to identify and appropriately treat these conditions accordingly. Initially, conservative treatment is adequate for a variety of pathologic conditions related to obesity. Read More

Angew Chem Int Ed Engl 2018 Nov 14. Epub 2018 Nov 14.

ETH Zurich, Department of Chemistry, Vladimir-Prelog-Weg 2, CH-8093, Zurich, SWITZERLAND.

Modern pentafluorosulfanyl (SF5) chemistry has an Achilles heel: synthetic accessibility. Herein, we present the first approach to aryl-SF4Cl compounds (key intermediates in state-of-the-art aryl-SF5 synthesis) that overcomes the reliance on hazardous fluorinating reagents and/or gas reagents (e.g. Read More

Phys Sportsmed 2018 Nov 14:1-6. Epub 2018 Nov 14.

a Department of Medicine and Science of Aging , University G. d'Annunzio , Chieti Scalo , Italy.

Objectives: The efficacy of platelet rich plasma in the treatment of Achilles tendinopathy is controversial. Despite positive results observed in open studies, randomized controlled trials failed to show difference against saline or rehabilitation. Aims of this retrospective observational study were to compare the efficacy of platelet-rich plasma and dry needling and to assess possible differences age and sex-related. Read More

J Biomech 2018 Oct 28. Epub 2018 Oct 28.

Menzies Health Institute Queensland, Griffith University, Gold Coast Campus, Australia.

Achilles tendon material properties and geometry are altered in Achilles tendinopathy. The purpose of this study was to determine the relative contributions of altered material properties and geometry to free Achilles tendon stress distribution during a sub-maximal contraction in tendinopathic relative to healthy tendons. Tendinopathic (n = 8) and healthy tendons (n = 8) were imaged at rest and during a sub-maximal voluntary isometric contraction using three-dimensional freehand ultrasound. Read More

Pediatr Exerc Sci 2018 Nov 14:1-10. Epub 2018 Nov 14.

1 University of Graz.

Purpose: The purpose of this study was to investigate the effects of functional progressive resistance training (PRT) and high-intensity circuit training (HICT) on the mechano-morphological properties of the plantar flexor muscle-tendon unit in children with spastic cerebral palsy.

Methods: Twenty-two children (12.8 [2. Read More