8,031 results match your criteria Achalasia


Clinical decision making and application of an active rehabilitation program for a person with the neuromuscular symptoms of Allgrove syndrome: a case report.

Authors:
Joseph T Adams

Physiother Theory Pract 2018 Dec 3:1-8. Epub 2018 Dec 3.

a Rusk Rehabilitation, Clinical Instructor, Department of Rehabilitation Medicine NYU School of Medicine , NYU Langone Health , New York , NY , USA.

Background: Allgrove syndrome is a multisystem disorder first described in 1978 and is classically associated with esophageal achalasia, alacrima, and adrenal insufficiency. Allgrove syndrome is caused by homozygous and/or compound heterozygous mutations on Chromosome 12q13, designated as "AAA" (Achalasia, Addisonianism Alacrima). AAA encodes the protein ALADIN (Alacrima, Achalasia, aDrenal Insufficiency Neurologic disorder), a member of the nuclear porin family forming the nuclear pore complex. Read More

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December 2018

Calcium Receptor and Nitric Oxide Synthase Expression in Circular Muscle of Lower Esophagus from Patients with Achalasia.

Chin Med J (Engl) 2018 Dec;131(23):2882-2885

Research Center, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, China.

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December 2018

Causing Empyema.

Case Rep Gastroenterol 2018 Sep-Dec;12(3):633-639. Epub 2018 Oct 24.

Division of Gastroenterology and Hepatology, St. Joseph's University Hospital Paterson, Paterson, New Jersey, USA.

Extraintestinal infection (CDI) is extremely uncommon. High mortality and poor outcomes have been observed among individuals with this rare medical condition. Empyema is one of the extraintestinal manifestations of CDI. Read More

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October 2018

Peroral Endoscopic Myotomy with Water Pump-Assisted Submucosal Tunnel Creation.

GE Port J Gastroenterol 2018 Nov 13;25(6):331-332. Epub 2018 Feb 13.

Serviço de Gastrenterologia, Centro Hospitalar de Lisboa Ocidental, Lisbon, Portugal.

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November 2018
2 Reads

Long-Term Efficacy of Peroral Endoscopic Myotomy for Patients with Achalasia: Outcomes with a Median Follow-Up of 36 Months.

Dig Dis Sci 2018 Nov 26. Epub 2018 Nov 26.

Department of Gastroenterology, First Affiliated Hospital of Zhejiang Chinese Medical University, 54 Youdian Road, Hangzhou, 310006, China.

Objective: This study aimed to evaluate the long-term efficacy of peroral endoscopic myotomy (POEM) for patients with achalasia.

Methods: Prospective data collected from 115 patients (median age 45 years; interquartile range 34-57) with achalasia who underwent POEM at the First Affiliated Hospital of ZheJiang Chinese Medical University with a median follow-up of 36 months were retrospectively analyzed. The Eckardt score and lower esophageal sphincter pressure changes were analyzed, and the gastroesophageal reflux was observed. Read More

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November 2018
1 Read

The dysphagia stress test for rapid assessment of swallowing difficulties in esophageal conditions.

Neurogastroenterol Motil 2018 Nov 25:e13512. Epub 2018 Nov 25.

Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Background: Esophageal dysphagia is a common symptom in gastroenterology practice. Current rapid assessment tools are limited to oropharyngeal dysphagia and do not translate well to esophageal conditions. We aim to create a novel tool, the dysphagia stress test (DST), to evaluate swallowing in patients with esophageal disease characterized by dysphagia. Read More

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November 2018
3 Reads

Preoperative Gastroesophageal Reflux Disorder Is Associated With Increased Morbidity in Patients Undergoing Abdominal Surgery.

J Surg Res 2018 Dec 8;232:587-594. Epub 2018 Aug 8.

Department of Surgery, University of Virginia, Charlottesville, Virginia.

Background: In North America, the prevalence of gastroesophageal reflux disorder ranges from 18.1% to 27.8%. Read More

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December 2018
2 Reads

Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia.

Clin Transl Gastroenterol 2018 Nov 19;9(11):208. Epub 2018 Nov 19.

Department of Microbiology and Immunology, Laboratory of Immunobiology, Rega Institute for Medical Research, KU Leuven, University of Leuven, Leuven, Belgium.

Objectives: Achalasia is a primary esophageal motility disorder resulting from selective loss of inhibitory neurons in the esophageal myenteric plexus, likely due to an autoimmune response with involvement of the adaptive immune system. Innate immune processes of the host constitute the bridge between environmental etiological factors and the adaptive immune system. Although these remain poorly investigated, they might be of diagnostic and therapeutic relevance. Read More

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November 2018
2 Reads

Mycobacterium fortuitum infection associated with achalasia.

Tunis Med 2018 May;96(5):311-313

The association achalasia and non tuberculous Mycobacteria lung infection is described in the literature. Most of the time Mycobacterium Fortuitum is responsible of aspiration pneumonia that didn't respond to usual antibiotic therapy. We report a new case about a 15 year-old woman with Allgrove's syndrome history. Read More

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May 2018
1 Read

Reintervention after Heller Myotomy for Achalasia: Is It Inevitable?

Ann Thorac Surg 2018 Nov 10. Epub 2018 Nov 10.

Department of Thoracic and Cardiovascular Surgery, Heart and Vascular Institute.

Background: Few studies of reintervention after Heller myotomy for achalasia set patients' expectations, assist therapeutic decision-making, and direct follow-up. Therefore, we investigated the frequency and type of symptoms and reinterventions post-myotomy based on achalasia type.

Methods: From 1/2006-3/2013, 248 patients who had preoperative high-resolution manometry and a timed barium esophagram (TBE) underwent Heller myotomy, 62 (25%) for type I, 162 (65%) type II, and 24 (10%) type III achalasia. Read More

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November 2018
6 Reads

Expanding the clinical phenotype of IARS2-related mitochondrial disease.

BMC Med Genet 2018 Nov 12;19(1):196. Epub 2018 Nov 12.

Genetics and Molecular Cell Sciences Research Centre, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

Background: IARS2 encodes a mitochondrial isoleucyl-tRNA synthetase, a highly conserved nuclear-encoded enzyme required for the charging of tRNAs with their cognate amino acid for translation. Recently, pathogenic IARS2 variants have been identified in a number of patients presenting broad clinical phenotypes with autosomal recessive inheritance. These phenotypes range from Leigh and West syndrome to a new syndrome abbreviated CAGSSS that is characterised by cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia, as well as cataract with no additional anomalies. Read More

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November 2018
7 Reads
2.080 Impact Factor

Intrasphincteric BoTox injections in Hirschsprung's disease: indications and outcome in 64 procedures over a ten-year period.

Minerva Pediatr 2018 Nov 7. Epub 2018 Nov 7.

Department of Pediatric Surgery, Giannina Gaslini Children's Hospital, Institute for Scientific Research, Genoa, Italy.

Background: Intrasphincteric Botulinum toxin (BoTox) injection for symptomatic postoperative anal achalasia in Hirschsprung's disease (HSCR) has found wide application in the last twenty years. The aim of this study is to describe effectiveness and functional outcome of a series of patients treated over a 10-year period.

Methods: All consecutive HSCR patients who received intrasphincteric BoTox injections between January 2007 and December 2016 were included. Read More

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November 2018
2 Reads

Peroral Endoscopic Myotomy for Complex Achalasia and the POEM Difficulty Score.

Dig Endosc 2018 Nov 12. Epub 2018 Nov 12.

Division of Gastroenterolgy, Showa University, Fujigaoka Hospital Fujigaoka1-30, Aoba-ku, Yokohama, 227-8501, Japan.

Background: Peroral endoscopic myotomy (POEM) for achalasia is technically more challenging to perform in patients with type III, multiple prior treatments, prior myotomy, and sigmoid-type. Here we present a series of consecutive patients with complex achalasia and introduce the POEM Difficulty Score (PDS).

Aim: To demonstrate the application and discuss the utility of the PDS, and present the feasibility, safety, and efficacy of POEM in complex achalasia patients. Read More

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November 2018
4 Reads

Transluminal Cancer Surgery.

Surg Oncol Clin N Am 2019 Jan 23;28(1):101-113. Epub 2018 Oct 23.

Department of Gastrointestinal Surgery, ICMDM, IDIBAPS, CIBEREHD, AIS Channel, Hospital Clínic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.

Transluminal surgery, also known as natural orifices endoluminal surgery, can be considered the most minimally invasive approach of gaining access to an organ. Although some approaches, such as transgastric or transvaginal cholecystectomy, have remained experimental, peroral endoscopic myotomy to treat achalasia and transanal total mesorectal excision to treat low rectal cancer have become accepted, safe, and feasible approaches by trained surgeons for selected patients. This article recapitulates the development of transluminal surgery from its experimental beginnings to the validated procedure it has become today. Read More

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January 2019
3 Reads

The Role of Botulinum Toxin Injections for Esophageal Motility Disorders.

Curr Treat Options Gastroenterol 2018 Dec;16(4):528-540

Gastroenterology Section, Department of Medicine, Lewis Katz School of Medicine at Temple University, 3401 N. Broad St., 8th floor Parkinson Pavilion, Philadelphia, PA, 19140, USA.

Purpose Of Review: The advancement of high-resolution esophageal manometry has led to improvement in the diagnosis of esophageal motility disorders. We reviewed the recent medical literature regarding the use of botulinum toxin (BTx) injections in the esophagus and the indications, current outcomes, and reported complications of this therapy.

Recent Findings: The response rates of BTx injection therapy vary depending on the esophageal motility disorder. Read More

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December 2018
5 Reads

Assessment of Clinical Outcomes after Peroral Endoscopic Myotomy via Esophageal Distensibility Measurements with the Endoluminal Functional Lumen Imaging Probe.

Gut Liver 2018 Oct 18. Epub 2018 Oct 18.

Department of Gastroenterology, Cha Bundang Medical Center, Cha University College of Medicine, Seongnam-si, Korea.

Background/aims: Endoluminal functional lumen imaging probe (EndoFLIP) is a modality that enables clinicians to measure volume-controlled distension of the esophagus. This study aimed to assess the utility of EndoFLIP in patients who had achalasia treated with peroral endoscopic myotomy (POEM). We hypothesized that improvement in the distensibility index (DI) is correlated with the postoperative clinical outcome of POEM. Read More

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October 2018
3 Reads

The Role of Botox in Colorectal Disorders.

Curr Treat Options Gastroenterol 2018 Dec;16(4):541-547

Sackler Faculty of Medicine, Tel Aviv University, P.O.B 39040, 69978, Ramat Aviv, Israel.

Purpose Of Review: To overview the current medical literature on the efficacy of botulism toxin treatment (BTX-A) for lower gastrointestinal disorders (GIT).

Recent Findings: BTX-A was found to have a short-term efficacy for the treatment of dyssynergic defecation. Surgical treatment was found to be more effective than BTX-A for the healing of chronic anal fissures, and BTX-A can be considered when surgery is undesirable. Read More

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December 2018
4 Reads

Bacteremia by Leuconostoc mesenteroides in an immunocompetent patient with chronic Chagas disease: a case report.

BMC Infect Dis 2018 Nov 3;18(1):547. Epub 2018 Nov 3.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes, s/n - Monte Alegre, Ribeirão Preto, SP, 14049-900, Brazil.

Background: The Leuconostoc mesenteroides are members of the Streptococcae family and currently has been recognized as potential pathogens. This case describes a bacteremia caused by L. mesenteroides in an immunocompetent patient affected by Chagas disease. Read More

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November 2018
3 Reads

Esophageal shortening after rapid drink test during esophageal high-resolution manometry: A relevant finding?

United European Gastroenterol J 2018 Nov 15;6(9):1323-1330. Epub 2018 Aug 15.

Digestive Physiology, Université de Lyon, France.

Background: Esophageal shortening (ES) might be observed during high-resolution manometry (HRM), in particular after the rapid drink test (RDT). We aimed to assess its diagnostic value in patients referred for HRM.

Methods: HRM of patients without previous esophagogastric surgery or endoscopic treatment was retrospectively reviewed using the Chicago Classification v3. Read More

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November 2018
4 Reads

Opioid-Induced Esophageal Dysfunction: An Emerging Entity with Sweeping Consequences.

Curr Treat Options Gastroenterol 2018 Dec;16(4):616-621

Center for Swallowing and Esophageal Disorders, Division of Gastroenterology, Hepatology, and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.

Adverse effects of opioids on the gastrointestinal tract are well known. However, with the rising epidemic of opioids, its detrimental effects on esophageal physiology are now being increasingly recognized. In this commentary, we briefly review the current evidence behind opioid-induced esophageal dysfunction with potential pathophysiology and treatment options. Read More

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December 2018
2 Reads

Triple A syndrome presenting as complicated hereditary spastic paraplegia.

Mol Genet Genomic Med 2018 Oct 31. Epub 2018 Oct 31.

Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.

Background: Hereditary spastic paraplegia (HSP) is a group of rare disorders characterized by spastic paraparesis and other symptoms. Often, other diseases can mimic HSP, which may delay diagnosis and treatment.

Methods: Whole exome sequencing was performed in families with clinically suspected HSP without a genetic diagnosis. Read More

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October 2018
4 Reads

Pneumatic dilation versus laparoscopic Heller's myotomy in the treatment of achalasia: systematic review and meta-analysis based on randomized controlled trials.

Dis Esophagus 2018 Oct 30. Epub 2018 Oct 30.

Gastroenterology Department, Endoscopy Unit, Hospital das Clínicas, School of Medicine, University of São Paulo, São Paulo, Brazil.

Achalasia is a primary esophageal motor disorder with a variety of causes. It is most common in Central and South America, where Chagas disease is endemic. In addition to the infectious etiology, achalasia can be idiopathic, autoimmune, or drug induced. Read More

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October 2018
2 Reads

[ACHALASIA: UPDATES ON DIAGNOSIS AND MANAGEMENT FROM THE LAST DECADE].

Harefuah 2018 Oct;157(10):668-671

Gastroenterology Institute, Nazareth EMMS hospital, affiliated to the Faculty of Medicine in the Galilee, Bar-Ilan University.

Introduction: Achalasia is a rare idiopathic disease, associated with significant morbidity and negative impact on life quality. The disorder is characterized by impairments in the esophageal motility and loss of the lower esophageal sphincter (LES) relaxation. Achalasia symptoms include dysphagia, regurgitations, chest pain, vomiting and weight loss. Read More

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October 2018
5 Reads

Peroral endoscopic myotomy leads to higher rates of abnormal esophageal acid exposure than laparoscopic Heller myotomy in achalasia.

Surg Endosc 2018 Oct 19. Epub 2018 Oct 19.

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Background And Aims: Peroral endoscopic myotomy (POEM) may be associated with higher rates of gastroesophageal reflux disease (GERD) than laparoscopic Heller's myotomy with fundoplication (LHM), since POEM is not combined with a fundoplication. However, peri-esophageal anti-reflux barriers are preserved in POEM, which might prevent GERD. Hence, we sought to compare the objective esophageal pH study findings in achalasia patients after POEM and LHM. Read More

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October 2018
1 Read

Neurotransmitter trafficking defect in a patient with clathrin (CLTC) variation presenting with intellectual disability and early-onset parkinsonism.

Parkinsonism Relat Disord 2018 Oct 11. Epub 2018 Oct 11.

Department of Human Neuroscience - Unit of Child Neurology and Psychiatry, Sapienza University, Rome, Italy. Electronic address:

Introduction: Clathrins play a key role in endocytosis, recycling, and trafficking as well as the generation of presynaptic vesicles. We report a new clinical condition associated with a de novo variant in the CLTC gene, which encodes the clathrin heavy polypeptide.

Case Report: This 30-year-old woman presented with a developmental disorder during childhood that progressed to mild cognitive decline in late childhood and relapsing-remitting hypokinetic-rigid syndrome with severe achalasia, weight loss, and mood disorder in adulthood. Read More

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October 2018
9 Reads

Preservation of the vagus nerves in subtotal esophagectomy without thoracotomy.

Acta Cir Bras 2018 Sep;33(9):834-841

PhD, Associate Professor, Division of Digestive Surgery, UFTM, Uberaba-MG, Brazil. Conception of the study, analysis and interpretation of data, manuscript writing, critical revision.

Purpose: To evaluate the outcome of transhiatal esophagectomy without thoracotomy and with preservation of the vagal trunks for the treatment of advanced megaesophagus.

Methods: Between March 2006 and September 2017, it was performed 136 transhiatal esophagectomies without thoracotomy by laparoscopy, with preservation of the vagus nerves. All patients were evaluated pre and postoperatively for respiratory and nutritional aspects Post operatively, some surgical aspects were evaluated like radiology and endoscopy of the digestive tract. Read More

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September 2018
3 Reads

Mycobacterium Fortuitum infection associated with achalasia.

Tunis Med 2018 Mar;96(3):227-229

The association between achalasia and no tuberculosis mycobacterial   lung infection is well described in the literature. MycobactériumFortuitum is often responsible, and the clinical's presentation   is an aspiration pneumonia resistant to usual antibiotic therapy. We report the case of a 15 year-old patient with the history of Allgrove syndrome. Read More

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March 2018
13 Reads

Can Eosinophilic Esophagitis Cause Achalasia and Other Esophageal Motility Disorders?

Am J Gastroenterol 2018 Nov 12;113(11):1594-1599. Epub 2018 Oct 12.

Division of Gastroenterology and Center for Esophageal Diseases, Baylor University Medical Center, and the Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, Texas, USA.

Eosinophilic esophagitis (EoE), a disorder identified by its esophageal mucosal features, often is associated with esophageal motility abnormalities, which are manifestations of esophageal muscle dysfunction. Those motility abnormalities sometimes normalize with treatments that reduce esophageal eosinophilia, suggesting that eosinophils can cause reversible esophageal motility disturbances, perhaps by releasing myoactive and neuroactive eosinophil products. Although achalasia uncommonly is associated with EoE as currently defined, most achalasia patients have evidence of an abnormal accumulation of eosinophils and/or their degranulation products in the esophageal muscularis propria, a location inaccessible to routine endoscopic evaluation. Read More

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November 2018
31 Reads

[High-resolution Manometry for Esophageal Motility Disorders].

Kyobu Geka 2018 Sep;71(10):894-899

Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan.

High-resolution manometry (HRM) has significant contribution in the field of esophageal motility disorders recently. The development of HRM has categorized various esophageal motility disorders focusing on patterns of esophageal motor function. Additionally, the Chicago classification criteria are widely used for manometric diagnosis. Read More

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September 2018
3 Reads

Bird's beak sign: Achalasia.

J Med Imaging Radiat Oncol 2018 Oct;62 Suppl 1:58

Department of Radiology, Concord Repatriation General Hospital, Concord, New South Wales, Australia.

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October 2018
1 Read

Occult Hiatal Hernia in Achalasia Patients: Its Incidence and Treatment Options.

Dig Surg 2018 Oct 10:1-8. Epub 2018 Oct 10.

Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Background: Achalasia patients occasionally coexist with esophageal hiatal hernias. The purpose of this study was to clarify the incidence and clinical features of achalasia cases concomitant with hiatal hernia, and to investigate whether our surgical technique was appropriate.

Methods: Consecutive achalasia patients who underwent laparoscopic Heller myotomy with Dor fundoplication (LHD) were extracted from the prospectively compiled surgical database, and the perioperative outcomes and the presence rate of hiatal hernia were obtained. Read More

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October 2018
2 Reads

ARE THE PERSISTENT SYMPTOMS TO PROTON PUMP INHIBITOR THERAPY DUE TO REFRACTORY GASTROESOPHAGEAL REFLUX DISEASE OR TO OTHER DISORDERS?

Arq Gastroenterol 2018 Nov 4;55Suppl 1(Suppl 1):85-91. Epub 2018 Oct 4.

Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Departamento de Gastroenterologia, São Paulo, SP, Brasil.

Background: Gastroesophageal reflux disease (GERD) is a clinical condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications. Transient lower esophageal sphincter relaxation is the main pathophysiological mechanism of GERD. Symptoms and complications can be related to the reflux of gastric contents into the esophagus, oral cavity, larynx and/or the lung. Read More

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November 2018
2 Reads

An Esophagogram or Tracheobronchogram? A Review of Barium Sulfate Aspiration.

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618802872. Epub 2018 Oct 4.

State University of New York Downstate Medical Center, Brooklyn, NY, USA.

The barium swallow is an important radiological investigation used for the diagnosis of upper gastrointestinal anatomical disorders like esophageal cancer, diverticulum, achalasia, foreign body, among others. Generally, it is believed to be a safe technique with rare complications, but few cases of barium sulfate aspiration have been reported in the literature with multiple complications. We are reporting a case of an elderly male who underwent esophagogram for the workup of chronic dysphagia, aspirated barium sulfate, and went into respiratory failure and circulatory shock several hours later. Read More

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October 2018
2 Reads

Peroral endoscopic myotomy (POEM) is effective in treatment of noncardiac chest pain caused by hypercontractile esophageal motility disorders: results of the POEM-HYPE-Study.

Z Gastroenterol 2018 Nov 8;56(11):1337-1342. Epub 2018 Oct 8.

Department of Internal Medicine and Gastroenterology, Elisabeth-Krankenhaus Essen, Essen, Germany.

Background: Noncardiac chest pain (NCCP) is recurrent angina pectoris-like pain without evidence of coronary heart disease in conventional diagnostic evaluation. In gastroenterology, managing of patients with NCCP is ambiguous to detect gastroesophageal reflux and hypercontractile esophageal motility disorders. Recently, peroral endoscopic myotomy (POEM) was established as treatment option in achalasia. Read More

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November 2018
7 Reads

Surgical Management of Gastroesophageal Reflux Disease in Patients with Severe Esophageal Dysmotility.

J Gastrointest Surg 2018 Oct 4. Epub 2018 Oct 4.

Center for Advanced Surgical Technology, University of Nebraska Medical Center, 986246 Nebraska Medical Center, Omaha, NE, 68198-6246, USA.

Background: Gastroesophageal reflux disease (GERD) and esophageal dysmotility are often disqualifying criteria for fundoplication due to dysphagia complications. A tailored partial fundoplication may improve GERD in patients with severe esophageal motility disorders. We evaluate this approach on GERD improvement in non-achalasia esophageal dysmotility patients. Read More

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October 2018
6 Reads

Gastro-oesophageal fistula in an achalasia patient following myotomy as an unusual cause of heartburn.

Authors:
G L Falk S C Little

Ann R Coll Surg Engl 2018 Oct 5:e1-e3. Epub 2018 Oct 5.

Sydney Heartburn Clinic , Lindfield , Australia.

We report a case of delayed presentation of a gastro-oesophageal fistula following a Heller myotomy and anterior fundoplication for achalasia in a 28-year-old man. After a period of symptom resolution following initial operation, dysphagia and severe heartburn commenced temporarily, related to non-steroidal anti-inflammatory drug (NSAID) use. Endoscopy demonstrated a secondary opening in the lower oesophagus and a barium swallow showed an oesophageal fistula to the stomach. Read More

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October 2018
1 Read

Peroral Endoscopic Myotomy in Diffuse Thickened Esophageal Wall in an Adolescent.

Case Rep Gastroenterol 2018 May-Aug;12(2):497-503. Epub 2018 Aug 23.

Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation.

Achalasia is an extremely rare pathology in children. Peroral endoscopic myotomy (POEM) is the gold standard for the surgical treatment of achalasia in adults, but only a limited number of cases of achalasia treatment using POEM in children have been published in the literature. Sometimes, high-resolution manometry signs of achalasia can mimic diffuse esophageal leiomyoma. Read More

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August 2018
2 Reads

Utility of Esophageal High-Resolution Manometry in Clinical Practice: First, Do HRM.

Dig Dis Sci 2018 Dec;63(12):3178-3186

Gastroenterology Section, Department of Medicine, Lewis Katz School of Medicine, Temple University School of Medicine, Philadelphia, PA, USA.

Esophageal high-resolution manometry (HRM) has advanced the understanding of esophageal motor function and the ability to diagnose and manage disorders of esophageal motility. In this review, we describe the indications for and the technical performance of HRM. The Chicago classification of esophageal motor function, now in its third iteration, streamlines and standardizes the nomenclature and basic interpretation of HRM data depicted as Clouse topographic plots. Read More

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December 2018
9 Reads

The Role of Novel Functional Probes in the Evaluation and Treatment of Esophageal Disease.

Thorac Surg Clin 2018 Nov;28(4):555-566

Foregut Surgeon, The Oregon Clinic, 4805 Northeast Glisan Street, Suite 6N60, Portland, OR 97213, USA.

The understanding of esophageal function and dysfunction in a variety of disease states has been driven largely by the introduction of a variety of measurement technologies. Included in these are contrast esophagram, computed tomography, high-resolution manometry, and 24-hour pH monitoring. Two novel measurement technologies, the functional lumen imaging probe (FLIP) and mucosal impedance (MI) catheter have recently introduced and studied. Read More

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November 2018
5 Reads

Peroral Endoscopic Myotomy for Achalasia.

Thorac Surg Clin 2018 Nov;28(4):499-506

Department of Cardiothoracic Surgery, University of Pittsburgh Medical Center, UPMC Presbyterian, Suite C-800, 200 Lothrop Street, Pittsburgh, PA 15213, USA. Electronic address:

Peroral endoscopic myotomy surgery is an incisionless, minimally invasive, natural orifice technique used to treat the symptoms of achalasia and other spastic disorders of the esophagus. Recent experience demonstrates that it can be performed safely by experienced esophageal surgeons and there are very good short-term outcomes comparable to laparoscopic myotomy. The rapid worldwide adoption of this technique demonstrates its potential to replace the current therapies available for achalasia. Read More

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November 2018
13 Reads

The effect of prior treatment on clinical outcomes in patients with achalasia undergoing peroral endoscopic myotomy.

Endoscopy 2018 Sep 27. Epub 2018 Sep 27.

Endoscopy Center and Endoscopy Research Institute, Zhongshan Hospital, Fudan University, Shanghai, China.

Background:  Peroral endoscopic myotomy (POEM) is a treatment option for patients with previous surgical or endoscopic treatment. We aimed to evaluate the influence of prior treatment on perioperative and follow-up outcomes in patients undergoing POEM.

Methods:  From August 2010 to December 2014, a total of 1384 patients with achalasia underwent POEM at our center. Read More

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September 2018
8 Reads

Effects of preoperative endoscopic pneumatic balloon dilatation on postoperative achalasia symptoms after Heller esophageal myotomy plus Dor fundoplication.

Turk J Gastroenterol 2018 09;29(5):543-548

Department of Gastroenterological Surgery, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.

Background/aims: Currently, forceful endoscopic pneumatic balloon dilatation (PBD), laparoscopic Heller myotomy (LHM) with or without an anti-reflux procedure, and peroral endoscopic myotomy are the preferred treatment options for achalasia. The aim of the present study was to retrospectively compare postoperative outcomes after LHM plus Dor fundoplication (DF) between patients who underwent prior endoscopic balloon dilatation and those who did not.

Materials And Methods: Sixty-five patients who underwent HM+DF between January 2008 and December 2016 were retrospectively analyzed. Read More

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September 2018
9 Reads

Routine esophageal manometry is not useful in patients with normal videoesophagram.

Surg Endosc 2018 Sep 24. Epub 2018 Sep 24.

Division of Upper GI and General Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, 1510 San Pablo St. #514, Los Angeles, CA, 90033, USA.

Background: Videoesophagram (VEG) and esophageal manometry (EM) are components of the preoperative evaluation for foregut surgery. EM is able to identify motility disorders and diminished contractility that may alter surgical planning. However, there are no clearly defined criteria to guide this. Read More

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September 2018
1 Read

Heterotopic ossification of the anterior abdominal wall.

Turk J Surg 2018 Sep 13:1-3. Epub 2018 Sep 13.

Department of General Surgery, İstanbul University-Cerrahpaşa, Cerrahpaşa School of Medicine, İstanbul, Turkey.

Heterotopic ossification is the formation of bone tissues in areas other than the skeletal system. It is more often seen as a complication of orthopedic surgery; however, it is a pathological condition that might be observed during the healing of abdominal incisions in the midline. The aim of this study is to present a case of a 63-year-old male patient with complaints of induration and pain on the region of his previous incision through which he had been operated for achalasia. Read More

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September 2018
1 Read

A Thousand and One Laparoscopic Heller Myotomies for Esophageal Achalasia: a 25-Year Experience at a Single Tertiary Center.

J Gastrointest Surg 2018 Sep 20. Epub 2018 Sep 20.

Clinica Chirurgica 3, Department of Surgical, Oncological and Gastroenterological Sciences, Università ed Azienda Ospedaliera di Padova, 2, via Giustiniani, 35128, Padua, Italy.

Background: The aim of this study was to assess the long-term outcome of laparoscopic Heller-Dor (LHD) myotomy to treat achalasia at a single high-volume institution in the past 25 years.

Methods: Patients undergoing LHD from 1992 to 2017 were prospectively registered in a dedicated database. Those who had already undergone surgical or endoscopic myotomy were ruled out. Read More

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September 2018
5 Reads

Achalasia and esophageal cancer: risks and links.

Clin Exp Gastroenterol 2018 6;11:309-316. Epub 2018 Sep 6.

Digestive Physiology and Motility Laboratory, Medical Biological Research Institute, Universidad Veracruzana, Veracruz, Mexico,

Esophageal cancer affects more than 4,50,000 persons worldwide, and its incidence has increased in recent years. It is the eighth most common cancer across the globe. The main histologic types are esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EA), and their associated risk factors are well known. Read More

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September 2018
2 Reads