70,727 results match your criteria Accounts of Chemical Research [Journal]


Health risk assessment on N-nitrosodimethylamine in drinking water and food in major cities of China with disability-adjusted life years (DALYs).

Ecotoxicol Environ Saf 2018 Dec 11;170:412-417. Epub 2018 Dec 11.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.

In this study, a health risk assessment of N-nitrosodimethylamine (NDMA) in drinking water and food was conducted using disability-adjusted life years (DALYs) in major cities of China. Considering the numerous non-detected values found in drinking water samples, a zero-inflated model was employed to obtain a more precise NDMA concentration distribution function in drinking water. With exogenous chronic daily intake of 1. Read More

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December 2018

ER stress promotes antitumor effects in BRAFi/MEKi resistant human melanoma induced by natural compound 4-nerolidylcathecol (4-NC).

Pharmacol Res 2018 Dec 11. Epub 2018 Dec 11.

Skin Biology Group, Clinical Chemistry and Toxicology Department, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Electronic address:

Melanoma accounts for only 4% of malignant neoplasms of the skin, but is considered the most serious because it is highly deadly. Mutations in the MAPK (Ras-Raf-MEK-ERK) pathway is closely linked to the lack of control of cell proliferation. Especially in melanoma, this pathway has become a target for the development of oncogene-targeted therapies, such as the potent inhibitors of v-Raf murine sarcoma viral oncogene homolog B (BRAFi) and mitogen-activated protein kinase kinase (MEKi). Read More

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December 2018
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Centennial records of cadmium and lead in NE China lake sediments.

Sci Total Environ 2018 Nov 28;657:548-557. Epub 2018 Nov 28.

EcoLab - Laboratoire Ecologie Fonctionnelle et Environnement, Université de Toulouse, CNRS, INPT, UPS, 31000 Toulouse, France.

Cores (15 to 40 cm of depth) were collected from 11 lakes of the Songnen Plain in northeastern China to reconstruct changes in potentially harmful trace element (PHTE) inputs as tracers of human activities. In each profile, most PHTE enrichment factors do not differ significantly from the pre-industrial values (EF < 1.5), except for Cd (EF = 2-5. Read More

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November 2018

Cell Biology and Dynamics of Neuronal Na/K-ATPase in Health and Diseases.

Neuropharmacology 2018 Dec 11. Epub 2018 Dec 11.

CNRS Neurodegenerative Diseases Laboratory (UMR9199), MiRCen, CEA Fontenay-aux-Roses, 18 route du Panorama, 92265, France.

Neuronal Na/K-ATPase is responsible for the maintenance of ionic gradient across plasma membrane. In doing so, in a healthy brain, Na/K-ATPase activity accounts for nearly half of total brain energy consumption. The α3-subunit containing Na/K-ATPase expression is restricted to neurons. Read More

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December 2018

Social identity mediates the positive effect of globalization on individual cooperation: Results from international experiments.

PLoS One 2018 14;13(12):e0206819. Epub 2018 Dec 14.

School of Psychology, University of New South Wales, Sydney, Australia.

Globalization is defined for individuals as their connectivity in global networks. Social identity is conceptualized as attachment and identification with a group. We measure individual involvement with global networks and local, national, and global social identity through a questionnaire. Read More

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December 2018

Electoral fortunes reverse, mindsets do not.

PLoS One 2018 14;13(12):e0208653. Epub 2018 Dec 14.

Department of Anthropology and Center for Behavior, Evolution and Culture, University of California Los Angeles, Los Angeles, California, United States of America.

Conservatives and liberals have previously been shown to differ in the propensity to view socially-transmitted information about hazards as more plausible than that concerning benefits. Given differences between conservatives and liberals in threat sensitivity and dangerous-world beliefs, correlations between political orientation and negatively-biased credulity may thus reflect endogenous mindsets. Alternatively, such results may owe to the political hierarchy at the time of previous research, as the tendency to see dark forces at work is thought to be greater among those who are out of political power. Read More

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December 2018

Validity and measurement invariance of the Unified Multidimensional Calling Scale (UMCS): A three-wave survey study.

PLoS One 2018 14;13(12):e0209348. Epub 2018 Dec 14.

Department of Political and Juridical Sciences and International Studies, University of Padova, Padova, Italy.

The accumulation of scientific knowledge on calling is limited by the absence of a common theoretical and measurement framework. Many different models of calling have been proposed, and we do not know how much research results that refer to a specific model are generalizable to different theoretical accounts of calling. In this article, we investigate whether two leading models of calling tackle the same construct. Read More

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December 2018

Motion fluency and object preference: Robust perceptual but fragile memory effects.

J Exp Psychol Learn Mem Cogn 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

In 8 experiments, we investigated motion fluency effects on object preference. In each experiment, distinct objects were repeatedly seen moving either fluently (with a smooth and predictable motion) or disfluently (with sudden and unpredictable direction changes) in a task where participants were required to respond to occasional brief changes in object appearance. Results show that (a) fluent objects are preferred over disfluent objects when ratings follow a moving presentation, (b) there is some evidence that object-motion associations can be learned with repeated exposures, (c) sufficiently potent motions can yield preference for fluent objects after a single viewing, and (d) learned associations do not transfer to situations where ratings follow a stationary presentation, even after deep levels of encoding. Read More

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December 2018

Preference for attractive faces is species-specific.

J Comp Psychol 2018 Dec 13. Epub 2018 Dec 13.

Universite Grenoble Alpes.

Studies on facial attractiveness in human adults, infants, and newborns have consistently reported a visual preference for faces rated as attractive compared with faces rated as unattractive. Biological accounts of facial attractiveness have typically presented such preferences as arising from adaptations for mate choice or as by-products of general sensory bias. In this cross-species study, we examined whether explicit ratings of attractiveness made by human judges would predict implicit visual preferences in other humans and also in rhesus macaques and, if they do, whether such preferences would extend beyond conspecific faces. Read More

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December 2018

Splenic marginal zone lymphoma leads to sinistral portal hypertension.

J Dig Dis 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.

Sinistral portal hypertension (SPH), also known as left-sided portal hypertension, accounts for 5% of all portal hypertension (PH) cases. SPH is commonly secondary to acute or chronic pancreatitis and pancreatic cancer and rarely secondary to peritoneal inflammatory disease, abdominal tumors or diseases of the spleen . Splenic marginal zone lymphoma (SMZL) is a rare type of non-Hodgkin's lymphoma that originates from the lymphocytes of the splenic white pulp. Read More

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December 2018
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Vestibular atelectasis: Decoding pressure and sound-induced nystagmus with bilateral vestibulopathy.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otorhinolaryngology, County General and Veterans Hospital Vukovar, Vukovar, Croatia.

We present the case of a 27-year-old male who presented with vertigo when pressing the entrance of his right auditory meatus and exposing his right ear to loud noise. A diagnostic procedure revealed bilateral labyrinth weakness, which was confirmed by caloric and rotational testing. The ocular vestibular evoked myogenic potentials investigation demonstrated a significant weakness of the right utriculus, whereas the cervical vestibular evoked myogenic potentials were normal, indicating preservation of the saccular response. Read More

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December 2018

The right to exit and skilled labour emigration: Ethical considerations for compulsory health service programmes.

Authors:
Yusuf Yuksekdag

Dev World Bioeth 2018 Dec 12. Epub 2018 Dec 12.

Compulsory (health) service contracts have recently received considerable attention in the normative literature. The service contracts are considered and offered as a permissible and liberal alternative to emigration restrictions if individuals relinquish their right to exit via contract in exchange for the state-funded tertiary education. To that end, the recent normative literature on the service programmes has particularly focused on discussing the circumstances or conditions in which the contracts should be signed, so that they are morally binding on the part of the skilled workers. Read More

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December 2018

Sexual coercion, consent and negotiation: processes of change amongst couples participating in the Indashyikirwa programme in Rwanda.

Cult Health Sex 2018 Dec 14:1-16. Epub 2018 Dec 14.

a Gender, Violence and Health Centre, London School of Hygiene and Tropical Medicine , London , UK.

Sexual coercion among married or cohabitating couples is a complex phenomenon with few effective strategies for prevention. This paper explores sexual coercion among couples from rural Rwanda who participated in Indashyikirwa, a 4-year intimate partner violence prevention programme that included a 5-month couples curriculum to promote equalitarian, non-violent relationships. Drawing on three rounds of longitudinal qualitative interviews with partners from 14 couples (28 individuals), this paper explores processes of change in experiences and conceptualisations of coerced sex over the course of the intervention and 1 year after. Read More

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December 2018

Essay: Half a Century of the Standard Model*,†.

Authors:
Steven Weinberg

Phys Rev Lett 2018 Nov;121(22):220001

Theory Group, Department of Physics, University of Texas at Austin.

The standard model is a quantum field theory that successfully accounts for the strong, weak, and electromagnetic interactions of the known elementary particles. In this essay I reminisce about the forerunners of the standard model, the beginnings of the model half a century ago, and its development and confirmation from then to the present. Read More

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November 2018

High-dose flecainide with low-dose β-blocker therapy in catecholaminergic polymorphic ventricular tachycardia: A case report and review of the literature.

J Cardiol Cases 2015 Jan 26;11(1):10-13. Epub 2014 Sep 26.

Department of Cardiology and Angiology I, Heart Center, University of Freiburg, Freiburg, Germany.

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is characterized by recurrent syncopes and sudden cardiac death triggered by sympathetic activation in young individuals without structural heart disease and a normal baseline electrocardiogram. There is reason to question whether the current expert consensus treatment recommendation, tolerated β-blockade alone or in combination with low-dose flecainide, is the antiarrhythmic treatment strategy in CPVT, as high doses of β-blockers may eventually lead to adverse side effects and β-blocker discontinuation. Indeed, β-blocker non-compliance accounts for around 5% of sudden cardiac deaths in CPVT patients. Read More

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January 2015

A rare presentation of appendicitis inside the femoral canal: case report and literature review.

Surg Case Rep 2018 Dec 13;4(1):143. Epub 2018 Dec 13.

Department of General surgery, Redcliffe Hospital, Redcliffe, QLD, 4020, Australia.

Background: Femoral hernia accounts for 3% of all the hernias, and in 0.5-5% of cases, the appendix can migrate through the femoral hernia and is called de Garengeot hernia. It is a very rare condition, and the incidence of appendicitis in this type of hernia is as low as 0. Read More

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December 2018

Nasopharyngeal angiofibroma in an elderly female patient: A rare case report.

Mol Clin Oncol 2018 Dec 5;9(6):702-704. Epub 2018 Oct 5.

Department of Sense Organs, Sapienza University of Rome, I-00186 Rome, Italy.

'Juvenile' nasopharyngeal angiofibroma, which accounts for <1% of all head and neck neoplasms, occurs predominantly in males between 10 and 18 years of age. The small number of patients older than 30 years confirms that presentation after this age is exceptional. Only rare cases of nasopharyngeal angiofibroma in female patients have been documented to date, and some authors believe that sex chromosome studies are indicated in such cases. Read More

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December 2018

Beneficial effect of additional treatment with widely available anticancer agents in advanced small lung cell carcinoma: A case report.

Authors:
Piotr J Kruk

Mol Clin Oncol 2018 Dec 5;9(6):647-650. Epub 2018 Oct 5.

Department of Family Medicine, Rząśnia Community-Based Health Center, 98-332 Rząśnia, Poland.

Small-cell lung carcinoma is a type of lung cancer characterized by very poor prognosis, as the majority of the patients have already developed metastases at initial diagnosis. Small-cell lung cancer accounts for ~15% of all lung cancer cases. The present study reports the case of a female patient with advanced-stage small-cell lung cancer. Read More

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December 2018

Radiotherapy-associated intra-abdominal angiosarcoma after prostatic adenocarcinoma: Case reports.

Mol Clin Oncol 2018 Dec 5;9(6):592-596. Epub 2018 Oct 5.

Pathology Service, University Hospital of Saint Joan, Faculty of Medicine, IISPV, 'Rovira i Virgili' University, Reus, 43204 Tarragona, Spain.

Angiosarcoma is a rare soft tissue neoplasm, which accounts for <1% of all soft tissue tumours. It has been previously reported that the incidence rate of angiosarcomas increases following radiotherapy. The present study reports two cases of intra-abdominal angiosarcoma associated with previous radiotherapy treatment. Read More

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December 2018
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Chromosome instability in neuroblastoma.

Oncol Lett 2018 Dec 3;16(6):6887-6894. Epub 2018 Oct 3.

Neuroblastoma Laboratory, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, I-35127 Padua, Italy.

Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low- and intermediate-risk classes, have favorable outcomes and display several numerical CNVs. Read More

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December 2018

The Structural Effects of Modality on the Rise of Symbolic Language: A Rebuttal of Evolutionary Accounts and a Laboratory Demonstration.

Front Psychol 2018 28;9:2300. Epub 2018 Nov 28.

Laboratoire de Sciences Phonétiques, Département de Linguistique, Université de Montréal, Montreal, QC, Canada.

Why does symbolic communication in humans develop primarily in an oral medium, and how do theories of language origin explain this? Non-human primates, despite their ability to learn and use symbolic signs, do not develop symbols as in oral language. This partly owes to the lack of a direct cortico-motoneuron control of vocalizations in these species compared to humans. Yet such modality-related factors that can impinge on the rise of symbolic language are interpreted differently in two types of evolutionary storylines. Read More

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November 2018

Managing stake and accountability in Prime Ministers' accounts of the "refugee crisis": A longitudinal analysis.

J Community Appl Soc Psychol 2018 Nov-Dec;28(6):406-429. Epub 2018 Nov 8.

Department of Social Research University of Helsinki Helsinki Finland.

Taking a (critical) discursive psychological approach, the present study explores the identity management of the Finnish and Swedish Prime Ministers (PM) in relation to the "refugee crisis" and their countries' asylum policies. By taking a longitudinal approach and analysing the PMs' accounts of the "refugee crisis" from 1-year period, we focused on the ways rhetorical devices related to ethos, logos, and pathos were used to manage the issues of stake and accountability, as well as on the ways in which categories were worked up to serve particular functions. Our comparative analysis demonstrated significant similarities in the Finnish and Swedish PMs' talk, especially with regard to the transfer from a discourse of pathos and ethos, describing refugees in terms of individualism and humaneness, to a discourse of logos, emphasizing rationality, justifying sharpened immigration policies, and homogenizing refugees. Read More

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November 2018

First Balanced Cross Section Across the Taurides Fold-Thrust Belt: Geological Constraints on the Subduction History of the Antalya Slab in Southern Anatolia.

Tectonics 2018 Oct 18;37(10):3738-3759. Epub 2018 Oct 18.

Department of Earth Sciences Utrecht University, Vening Meineszgebouw A Utrecht Netherlands.

Eastern Mediterranean subduction accommodated Africa-Eurasia convergence since Mesozoic time and produced multiple subducted slab fragments in the mantle below Anatolia. These included the north dipping Cyprus and ENE-dipping Antalya slabs, which are currently separated by an upper mantle slab gap. Segmentation of these slabs, and associated mantle flow, may have contributed to <8 Ma uplift of the Central Anatolian Plateau. Read More

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October 2018

How I treat MDS after hypomethylating agent failure.

Authors:
Valeria Santini

Blood 2018 Dec 13. Epub 2018 Dec 13.

MDS Unit, Division of Hematology, AOU Careggi-University of Florence, Florence, Italy, Italy

Hypomethylating agents (HMA), azacitidine and decitabine are standard of care for myelodysplastic syndromes. Response to these agents accounts for around 50% of treated patients and duration of response, although variable, is transient. Prediction of response to HMA is possible with clinical and molecular parameters, but alternative approved treatments are not available and in case of HMA failure, there are no standard therapeutic opportunities. Read More

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December 2018

A multi-factorial analysis of bone morphology and fracture strength of rat femur in response to ovariectomy.

J Orthop Surg Res 2018 Dec 13;13(1):318. Epub 2018 Dec 13.

Division of Bio-Prosthodontics, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: Postmenopausal osteoporosis develops due to a deficiency of estrogen that causes a decrease in bone mass and changes in the macro- and micro-architectural structure of the bone, leading to the loss of mechanical strength and an increased risk of fracture. Although the assessment of bone mineral density (BMD) has been widely used as a gold standard for diagnostic screening of bone fracture risks, it accounts for only a part of the variation in bone fragility; thus, it is necessary to consider other determinants of bone strength. Therefore, we aimed to comprehensively evaluate the architectural changes of the bone that influence bone fracture strength, together with the different sensitivities of cortical and trabecular bone in response to ovariectomy (OVX). Read More

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December 2018

United States Physician Preferences Regarding Healthcare Financing Options: A Multistate Survey.

Pharmacy (Basel) 2018 Dec 9;6(4). Epub 2018 Dec 9.

College of Business, Western New England University, 1215 Wilbraham Road, Springfield, MA 01119, USA.

Not much is currently known about United States (US) physicians' opinions about healthcare financing, specifically subsequent to the creation and implementation of the Affordable Care Act (ACA). A four state survey of practicing US based physicians' opinions about healthcare financing following ACA passage and implementation. Physician leaders practicing in the state of New York, Texas, Colorado and Mississippi were surveyed. Read More

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December 2018

Altered Purinergic Receptor Sensitivity in Type 2 Diabetes-Associated Endothelial Dysfunction and Up₄A-Mediated Vascular Contraction.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Unit of Cardiology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.

Purinergic signaling may be altered in diabetes accounting for endothelial dysfunction. Uridine adenosine tetraphosphate (Up₄A), a novel dinucleotide substance, regulates vascular function via both purinergic P1 and P2 receptors (PR). Up₄A enhances vascular contraction in isolated arteries of diabetic rats likely through P2R. Read More

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December 2018

Cutaneous squamous cell carcinoma: predictors of positive and close margins and outcomes of re-excision in Northland, New Zealand.

N Z Med J 2018 Dec 14;131(1487):23-29. Epub 2018 Dec 14.

Department of General Surgery, Whangarei Hospital, Northland; Consultant General and Colorectal Surgeon, Whangarei Hospital, Northland; Honorary Senior Lecturer, Department of Surgery, University of Auckland, Auckland.

Background: Non-melanoma skin cancer (NMSC) is the most commonly diagnosed and costly cancer in Australasia. Cutaneous squamous cell carcinoma (cSCC) accounts for approximately 25% of NMSC. A better understanding of predictors of close and positive margins following surgical excision will help guide treatment. Read More

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December 2018

How Does the O-Methylation Regulate the Excited-State Decay of Guanine Monomers.

J Phys Chem B 2018 Dec 13. Epub 2018 Dec 13.

In this study, the photoinduced ultrafast deactivations of O6-methylguanosine in aqueous solution are mapped by employing multireference methods with implicit solvation model on a reduced model compound 9-methyl-O6-methylguanine (9Me-6MeGua). Although four S1/S0 minimal energy conical intersections (MECIs) are located, energy profiles indicated that only two of them are involved in excited-state decay processes and account for the C2 and C6 reaction coordinates, respectively. To reach both the involved MECIs, 9Me-6MeGua need to surmount an energy barrier. Read More

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December 2018

Drug Pricing and Value in Oncology.

Recent Results Cancer Res 2019 ;213:153-167

The Wharton School, University of Pennsylvania, Philadelphia, USA.

This paper first reviews the evidence on price levels, price growth, and value for cancer drugs. The available evidence suggests that prices for originator (brand-name) drugs are rising significantly more rapidly than general inflation, but the available data are inadequate for robust comparisons between cancer and other categories of specialty drugs. We then examine the factors contributing to high and rising prices for cancer drugs. Read More

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January 2019

Variable and intermittent grip force control in response to differing load force dynamics.

Exp Brain Res 2018 Dec 12. Epub 2018 Dec 12.

Department of Psychology, Center for Cognition, Action, and Perception, University of Cincinnati, Edwards Center 1, Cincinnati, OH, 45221-0376, USA.

A recent study (Grover et al. Exp Brain Res 236(10):2531-2544, 2018) found that the grip force applied to maintain grasp of a hand-held object exhibited intermittent coupling to the changing load forces exerted by the object as it was oscillated. In particular, the strength and consistency of grip force response to load force oscillations was tied to overall load force levels and the prominence of load force oscillations. Read More

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December 2018

A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma.

Oncol Rep 2018 Nov 2. Epub 2018 Nov 2.

Department of Cell Biology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100050, P.R. China.

Clinical non‑functioning pituitary adenoma (NFPA) accounts for >30% of all pituitary adenomas, and the recurrence rate is notably high. The ability to predict tumour recurrence during initial surgery will aid in determining if adjunctive therapy is required to reduce recurrence. With the aim of developing a circular RNA (circRNA) signature to improve prognosis prediction in NFPA, the present study examined the circRNA expression profiles in 73 patients with NFPA from Beijing Tiantan Hospital using high‑throughput RNA chip technology. Read More

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November 2018

Assessing Financial Impacts of Subclinical Mastitis on Colombian Dairy Farms.

Front Vet Sci 2018 27;5:273. Epub 2018 Nov 27.

Faculty of Economic and Social Sciences, Universidad de La Salle, Bogota, Colombia.

Bovine mastitis is a dairy cattle disease with high economic impact. Subclinical mastitis (SCM) contributes to most of the financial losses. Colombia dairy sector accounts for 2. Read More

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November 2018

Astroglial Ca-Dependent Hyperexcitability Requires P2Y Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy.

Front Cell Neurosci 2018 23;12:446. Epub 2018 Nov 23.

Centro de Neurobiología y Plasticidad Cerebral CNPC, Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile.

Astrocytes from the hippocampus of chronic epileptic rats exhibit an abnormal pattern of intracellular calcium oscillations, characterized by an augmented frequency of long lasting spontaneous Ca transients, which are sensitive to purinergic receptor antagonists but resistant to tetrodotoxin. The above suggests that alterations in astroglial Ca-dependent excitability observed in the epileptic tissue could arise from changes in astrocyte-to-astrocyte signaling, which is mainly mediated by purines in physiological and pathological conditions. In spite of that, how purinergic signaling contributes to astrocyte dysfunction in epilepsy remains unclear. Read More

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November 2018

A Putative Mutation Hotspot of the AGXT Gene Associated with Primary Hyperoxaluria Type 1 in the Chinese Population.

Tohoku J Exp Med 2018 ;246(4):233-241

Department of Laboratory Animal Center, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Primary hyperoxaluria type 1 (PH1), a rare autosomal recessive disorder, is characterized by renal stones, nephrocalcinosis, and chronic kidney disease. PH1 is caused by defects in alanine glyoxylate aminotransferase (AGT, 392 amino-acid residues), which is encoded by the alanine-glyoxylate and serine-pyruvate aminotransferase (AGXT) gene. This study aimed to determine the clinical, biochemical, and mutation spectrum of patients with PH1 from mainland China. Read More

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January 2018

Call to participate in the international study of traumatic brain injury results (Global Neurotrauma Outcomes Study).

Neurocirugia (Astur) 2018 Dec 9. Epub 2018 Dec 9.

Departamento de Neurocirugía, Addenbrookés Hospital, Cambridge, Reino Unido.

Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. The GNOS is a multi-centre international, prospective cohort study. This study is the first global neurosurgical study that aims to provide a comprehensive picture of the management and outcomes of patients undergoing emergency surgery for TBI worldwide. Read More

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December 2018

Patterns of common skin infections among children living with HIV/AIDS in Hawassa City, Ethiopia: a cross sectional study.

BMC Res Notes 2018 Dec 12;11(1):881. Epub 2018 Dec 12.

Faculty of Health Sciences, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Objectives: Skin disorders are the most common health problems seen among HIV positive patients. It presents with a variety of manifestations which can cause significant morbidity. This study was aimed to assess the prevalence of common skin problems among children living with HIV/AIDS at Hawassa University Comprehensive Specialized Hospital, Hawassa, Ethiopia, 2017/2018. Read More

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December 2018

What's missing in autism spectrum disorder motor assessments?

J Neurodev Disord 2018 Dec 13;10(1):33. Epub 2018 Dec 13.

UCLA Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, 760 Westwood Plaza, Room A7-424, Los Angeles, CA, 90095, USA.

Background: Motor delays and impairments in autism spectrum disorders (ASD) are extremely common and often herald the emergence of pervasive atypical development. Clinical accounts of ASD and standardized measures of motor function have identified deficits in multiple motor domains. However, literature describing frequently used standardized motor assessments in children with ASD, their test properties, and their limitations are sparse. Read More

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December 2018
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'Going the extra mile' for older people with dementia: Exploring the voluntary labour of homecare workers.

Dementia (London) 2018 Dec 12:1471301218817616. Epub 2018 Dec 12.

School of Science and the Environment, Manchester Metropolitan University, UK.

Homecare workers provide essential physical, social and emotional support to growing numbers of older people with dementia in the UK. Although it is acknowledged that the work can sometimes be demanding, some homecare workers regularly 'go the extra mile' for service users, working above and beyond the usual remit of the job. This form of voluntarism has been interpreted as an expression of an essentially caring nature, but also as the product of a work environment structured to tacitly endorse the provision of unpaid labour. Read More

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December 2018

Identity processes in smokers who want to quit smoking: A longitudinal interpretative phenomenological analysis.

Health (London) 2018 Dec 12:1363459318817923. Epub 2018 Dec 12.

University of Leuven, Belgium.

The importance of identity in smoking cessation is increasingly becoming recognized by researchers. This study is the first in-depth longitudinal qualitative investigation of identity change processes among smokers who intend to quit. Participants' accounts of smoking, attempts to quit and sense of identity were explored over time to examine identity continuity and change. Read More

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December 2018

Scalable synthesis of a foam-like FeS nanostructure by a solution combustion-sulfurization process for high-capacity sodium-ion batteries.

Nanoscale 2018 Dec 7. Epub 2018 Dec 7.

Key Laboratory for Soft Chemistry and Functional Materials (Nanjing University of Science and Technology), Ministry of Education, Nanjing 210094, China.

Pyrite-type FeS2 is regarded as a promising anode material for sodium ion batteries. The synthesis of FeS2 in large quantities accompanied by an improved cycling stability, as well as retaining high theoretical capacity, is highly desirable for its commercialization. Herein, we present a scalable and simple strategy to prepare a foam-like FeS2 (F-FeS2) nanostructure by combining solution combustion synthesis and solid-state sulfurization. Read More

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December 2018

Assessment of Pesticide-Related Pollution and Occupational Health of Vegetable Farmers in Benguet Province, Philippines.

J Health Pollut 2017 Dec 18;7(16):49-57. Epub 2017 Dec 18.

National Institutes of Health, University of the Philippines Manila, Republic of the Philippines.

Background: Agriculture accounts for 20% of the national income in the Philippines. In order to boost agricultural activity and prevent crop damage, farmers rely on pesticides for vector control and management.

Objectives: The present study assessed the pesticide exposure and occupational health of agricultural farmers in the Philippines. Read More

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December 2017

Aberrant Metabolism in Hepatocellular Carcinoma Provides Diagnostic and Therapeutic Opportunities.

Oxid Med Cell Longev 2018 4;2018:7512159. Epub 2018 Nov 4.

Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.

Hepatocellular carcinoma (HCC) accounts for over 80% of liver cancer cases and is highly malignant, recurrent, drug-resistant, and often diagnosed in the advanced stage. It is clear that early diagnosis and a better understanding of molecular mechanisms contributing to HCC progression is clinically urgent. Metabolic alterations clearly characterize HCC tumors. Read More

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November 2018

Universal understanding of nematicity and magnetism in Fe-pnictides and FeSe.

J Phys Condens Matter 2018 Nov 26. Epub 2018 Nov 26.

Beijing CSRC, Beijing, CHINA.

By employing the mean field and variational Monte Carlo methods, we investigate the iron-based superconductors (FeSCs) based on a realistic five-orbital Hubbard model in which an off-site Coulomb interaction V is explicitly included. Our results demonstrate that V plays an important role in stabilizing the nematic state in both Fe-pnictides and FeSe. Below a critical Vc, the model is shown to lie in the striped antiferromagnetic ground state, and an increasing of V leads to an energy degeneracy between different magnetic configurations. Read More

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November 2018

One-stage random effects meta-analysis using linear mixed models for aggregate continuous outcome data.

Res Synth Methods 2018 Dec 6. Epub 2018 Dec 6.

Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.

The vast majority of meta-analyses uses summary/aggregate data retrieved from published studies in contrast to meta-analysis of individual participant data (IPD). When the outcome is continuous and IPD are available, linear mixed modelling methods canbe employed in a one-stage approach. This allows for flexible modelling of within-study variability and between-study effects and accounts for the uncertainty in the estimates of between-study and within-study residual variances. Read More

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December 2018

Effect of double-layer structure in intramucosal gastric signet-ring cell carcinoma on lymph node metastasis: a retrospective, single-center study.

Gastric Cancer 2018 Dec 6. Epub 2018 Dec 6.

Division of Endoscopy, Shizuoka Cancer Center, Shizuoka, Japan.

Background: Among all types of gastric cancer (GC), signet-ring cell carcinoma (sig-GC) accounts for 4-17% of cases. The prognosis of early sig-GC is relatively good, with the 5-year survival rate at 99.7%. Read More

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December 2018

The spatial epidemiology of sickle-cell anaemia in India.

Sci Rep 2018 Dec 6;8(1):17685. Epub 2018 Dec 6.

Evolutionary Ecology of Infectious Disease Group, Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK.

Sickle-cell anaemia (SCA) is a neglected chronic disorder of increasing global health importance, with India estimated to have the second highest burden of the disease. In the country, SCA is particularly prevalent in scheduled populations, which comprise the most socioeconomically disadvantaged communities. We compiled a geodatabase of a substantial number of SCA surveys carried out in India over the last decade. Read More

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December 2018
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The efficacy and safety of ciclesonide for the treatment of perennial allergic rhinitis: a systematic review and meta-analysis.

Braz J Otorhinolaryngol 2018 Nov 22. Epub 2018 Nov 22.

The Teaching Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China; Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China. Electronic address:

Introduction: Allergic rhinitis is a chronic inflammatory disease which affects 1 out of 6 individuals. Perennial allergic rhinitis accounts for 40% of AR cases. Ciclesonide is one of the relatively new intranasal steroid for allergic rhinitis. Read More

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November 2018

Proportion and factors of death among preterm neonates admitted in University of Gondar comprehensive specialized hospital neonatal intensive care unit, Northwest Ethiopia.

BMC Res Notes 2018 Dec 6;11(1):867. Epub 2018 Dec 6.

Department of Health Economics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: Neonatal mortality accounts for 43% of under-five child mortality in Ethiopia where preterm is the second leading cause of neonatal death and steadily increased in low-income countries. Therefore, assessing the proportion of death and associated factors among preterm neonates has a paramount importance in designing an effective strategy to intervene and achieve sustainable development goal.

Results: In this study proportion of preterm neonatal death in this study was 28. Read More

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December 2018