3,824 results match your criteria Accounts Of Chemical Research[Journal]


Improving Homogeneous Cationic Gold Catalysis through a Mechanism-Based Approach.

Acc Chem Res 2019 Apr 19. Epub 2019 Apr 19.

Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry, Chemical Engineering and Biotechnology , Donghua University , Shanghai 201620 , China.

Homogeneous gold catalysis is regarded as a landmark addition to the field of organic synthesis. It is the most effective way to activate alkynes for the addition of a diverse host of nucleophiles. However, the literature reveals that a relatively high catalyst loading is needed in many gold-catalyzed applications (1-10 mol %), which is impractical in large-scale synthesis or multistep synthesis because of the high price and recyclization difficulty of the gold. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00544
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http://dx.doi.org/10.1021/acs.accounts.8b00544DOI Listing
April 2019
1 Read

Nonviral Gene Delivery with Cationic Glycopolymers.

Acc Chem Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemistry , University of Minnesota , 207 Pleasant Street SE , Minneapolis , Minnesota 55455 , United States.

The field of gene therapy, which aims to treat patients by modulating gene expression, has come to fruition and has landed several landmark FDA approvals. Most gene therapies currently rely on viral vectors to deliver nucleic acid cargo into cells, but there is significant interest in moving toward chemical-based methods, such as polymer-based vectors, due to their low cost, immunocompatibility, and tunability. The full potential of polymer-based delivery systems has yet to be realized, however, because most polymeric transfection reagents are either too inefficient or too toxic for use in the clinic. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00665
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http://dx.doi.org/10.1021/acs.accounts.8b00665DOI Listing
April 2019
1 Read

Controlling Nanoparticles with Atomic Precision.

Acc Chem Res 2019 Jan;52(1)

The University of Tokyo.

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http://dx.doi.org/10.1021/acs.accounts.8b00631DOI Listing
January 2019

Toward the Targeted Design of Molecular Ferroelectrics: Modifying Molecular Symmetries and Homochirality.

Acc Chem Res 2019 Apr 15. Epub 2019 Apr 15.

Jiangsu Key Laboratory for Science and Applications of Molecular Ferroelectrics , Southeast University , Nanjing 211189 , People's Republic of China.

Although the first ferroelectric discovered in 1920 is Rochelle salt, a typical molecular ferroelectric, the front-runners that have been extensively studied and widely used in diverse applications, such as memory elements, capacitors, sensors, and actuators, are inorganic ferroelectrics with excellent electrical, mechanical, and optical properties. With the increased concerns about the environment, energy, and cost, molecular ferroelectrics are becoming promising supplements for inorganic ferroelectrics. The unique advantages of high structural tunability and homochirality, which are unavailable in their inorganic counterparts, make molecular systems a good platform for manipulating ferroelectricity. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00677DOI Listing
April 2019
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Allenation of Terminal Alkynes with Aldehydes and Ketones.

Acc Chem Res 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Recognition and Synthesis, Department of Chemistry , Zhejiang University , Hangzhou , 310027 Zhejiang , People's Republic of China.

So far, over 150 natural products and pharmaceuticals containing an allene moiety have been identified. During the last two decades, allenes have also been demonstrated as synthetically versatile starting materials in organic synthesis. In comparison to alkenes and alkynes, allenes are unique unsaturated hydrocarbons due to their axial chirality, which could be transformed to central chirality via chirality transfer to provide an irreplaceable entry to chiral molecules. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00023DOI Listing
April 2019
3 Reads

Reactivity of [FeS] Clusters toward C1 Substrates: Mechanism, Implications, and Potential Applications.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Molecular Biology and Biochemistry , University of California , Irvine , California 92697-3900 , United States.

FeS proteins are metalloproteins prevalent in the metabolic pathways of most organisms, playing key roles in a wide range of essential cellular processes. A member of this protein family, the Fe protein of nitrogenase, is a homodimer that contains a redox-active [FeS] cluster at the subunit interface and an ATP-binding site within each subunit. During catalysis, the Fe protein serves as the obligate electron donor for its catalytic partner, transferring electrons concomitant with ATP hydrolysis to the cofactor site of the catalytic component to enable substrate reduction. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00063DOI Listing

Bioinspired and Biomimetic Nanomedicines.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Bioengineering , University of California , Los Angeles , California 90095 , United States.

Nanomedicine development aims to enhance the efficacy, accuracy, safety, and/or compliance of diagnosis and treatment of diseases by leveraging the unique properties of engineered nanomaterials. To this end, a multitude of organic and inorganic nanoparticles have been designed to facilitate drug delivery, sensing, and imaging, some of which are currently in clinical trials or have been approved by the Food and Drug Administration (FDA). In the process, the increasing knowledge in understanding how natural particulates, including cells, pathogens, and organelles, interact with body and cellular systems has spurred efforts to mimic their morphology and functions for developing new generations of nanomedicine formulations. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00079
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http://dx.doi.org/10.1021/acs.accounts.9b00079DOI Listing
April 2019
6 Reads

Metal-Organic Framework-Templated Biomaterials: Recent Progress in Synthesis, Functionalization, and Applications.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Institute of Functional Interfaces , Karlsruhe Institute of Technology , Hermann-von Helmholtz-Platz 1 , D-76344 Eggenstein-Leopoldshafen , Germany.

The integration of a porous crystalline framework with soft polymers to create novel biomaterials has tremendous potential yet remains very challenging to date. Metal-organic framework (MOF)-templated polymers (MTPs) have emerged as persistent modular materials that can be tailored for desired biofunctions. These represent a novel class of hierarchically structured assemblies that combine the advantages of MOFs (precisely controlled structure, enormous diversity in framework topology, and high porosity) with the intrinsic behaviors of polymers (soft texture, flexibility, biocompatibility, and improved stability under physiological conditions). Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00039
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http://dx.doi.org/10.1021/acs.accounts.9b00039DOI Listing
April 2019
1 Read

Semiconducting Perylene Diimide Nanostructure: Multifunctional Phototheranostic Nanoplatform.

Acc Chem Res 2019 Apr 12. Epub 2019 Apr 12.

Laboratory of Molecular Imaging and Nanomedicine (LOMIN) , National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH) , Bethesda , Maryland 20892 , United States.

Precision medicine requires noninvasive and accurate early diagnosis and individually appropriate treatments. Phototheranostics has been considered a frontier precision medical technology to provide rapid and safe disease localization and efficient cure. Harnessing the power of advanced nanomedicine with photonics, phototheranostics is rapidly developing and progressively becoming irreplaceable in modern medicine. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00064
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http://dx.doi.org/10.1021/acs.accounts.9b00064DOI Listing
April 2019
2 Reads

De Novo Design of Four-Helix Bundle Metalloproteins: One Scaffold, Diverse Reactivities.

Acc Chem Res 2019 Apr 11. Epub 2019 Apr 11.

Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute , University of California at San Francisco , San Francisco , California 94158-9001 , United States.

De novo protein design represents an attractive approach for testing and extending our understanding of metalloprotein structure and function. Here, we describe our work on the design of DF (Due Ferri or two-iron in Italian), a minimalist model for the active sites of much larger and more complex natural diiron and dimanganese proteins. In nature, diiron and dimanganese proteins protypically bind their ions in 4-Glu, 2-His environments, and they catalyze diverse reactions, ranging from hydrolysis, to O-dependent chemistry, to decarbonylation of aldehydes. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00674
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http://dx.doi.org/10.1021/acs.accounts.8b00674DOI Listing
April 2019
5 Reads

Manipulating Spin Transition To Achieve Switchable Multifunctions.

Acc Chem Res 2019 Apr 11. Epub 2019 Apr 11.

State Key Laboratory of Fine Chemicals , Dalian University of Technology , 2 Linggong Road , Dalian 116024 , P. R. China.

The spin transition of metal ions involves interconversion between electron configurations exhibiting considerably different functions and plays a substantial role in the chemical, physical, and biological fields. The photoinduced spin transition offers a promising approach to tune various physical properties with high spatial and temporal resolutions for producing smart multifunctional materials not only to explore their basic science but also to satisfy the demands of the next-generation photoswitchable-molecule-based devices. Therefore, it is attracting considerable interest to utilize photoinduced spin transition to simultaneously tune multifunctions. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00049DOI Listing

Functionalization and Patterning of Self-Assembled Monolayers and Polymer Brushes Using Microcontact Chemistry.

Acc Chem Res 2019 Apr 10. Epub 2019 Apr 10.

Center for Soft Nanoscience and Organic Chemistry Institute , Westfälische Wilhelms-Universität Münster , Busso-Peus-Strasse 10 , 48149 Münster , Germany.

Because the surface connects a material to its environment, the functionalization, modification, and patterning of surfaces is key to a wide range of materials applied in microelectronics, displays, sensing, microarrays, photovoltaics, catalysis, and other fields. Self-assembled monolayers (SAMs), which can be deposited on a wide range of inorganic materials, are only a few nanometers thick, yet they can radically change the properties of the resulting interface. Alternatively, thin polymer films composed of polymer brushes grown from the surface provide a more robust molecular modification of inorganic materials. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00041DOI Listing

Toward Realizing Multifunctionality: Photoactive and Selective Adsorbents for the Removal of Inorganics in Water Treatment.

Acc Chem Res 2019 Apr 10. Epub 2019 Apr 10.

School of Forestry and Environmental Studies , Yale University , 195 Prospect Street , New Haven , Connecticut 06511 , United States.

Persistent and potentially toxic inorganic oxoanions (e.g., arsenic and selenium) are one class of contaminants of concern in drinking water for which treatment technologies must be improved. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00668DOI Listing

Projection-Based Wavefunction-in-DFT Embedding.

Acc Chem Res 2019 Apr 10. Epub 2019 Apr 10.

Division of Chemistry and Chemical Engineering , California Institute of Technology , Pasadena , California 91125 , United States.

Complex chemical systems present challenges to electronic structure theory stemming from large system sizes, subtle interactions, coupled dynamical time scales, and electronically nonadiabatic effects. New methods are needed to perform reliable, rigorous, and affordable electronic structure calculations for simulating the properties and dynamics of such systems. This Account reviews projection-based quantum embedding for electronic structure, which provides a formally exact method for density functional theory (DFT) embedding. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00672DOI Listing

DNA Adduct-Directed Synthetic Nucleosides.

Acc Chem Res 2019 Apr 9. Epub 2019 Apr 9.

Department of Health Sciences and Technology , ETH Zürich , Schmelzbergstrasse 9 , Zürich 8092 , Switzerland.

Chemical damage to DNA is a key initiator of adverse biological consequences due to disruption of the faithful reading of the genetic code. For example, O-alkylguanine ( O-alkylG) DNA adducts are strongly miscoding during DNA replication when the damaged nucleobase is a template for polymerase-mediated translesion DNA synthesis. Thus, mutations derived from O-alkylG adducts can have severe adverse effects on protein translation and function and are an early event in the initiation of carcinogenesis. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00054DOI Listing

Nanobubble Technologies Offer Opportunities To Improve Water Treatment.

Acc Chem Res 2019 Apr 8. Epub 2019 Apr 8.

Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment, School of Sustainable Engineering and the Built Environment , Arizona State University , Tempe , Arizona 85287-5306 , United States.

Since first hypothesizing the existence of nanobubbles (NBs) in 1994, the empirical study of NB properties and commercialization of NB generators have rapidly evolved. NBs are stable spherical packages of gas within liquid and are operationally defined as having diameters less than 1000 nm, though they are typically in the range of 100 nm in one dimension. While theories still lack the ability to explain empirical evidence for formation of stable NBs in water, numerous NB applications have emerged in different fields, including water and wastewater purification where NBs offer the potential to replace or improve efficiency of current treatment processes. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00606DOI Listing
April 2019
3 Reads

Covalent and Noncovalent Approaches to Rigid Coplanar π-Conjugated Molecules and Macromolecules.

Acc Chem Res 2019 Apr 3;52(4):1089-1100. Epub 2019 Apr 3.

Department of Chemistry , Texas A&M University , 3255 TAMU , College Station , Texas 77843 , United States.

Molecular conformation and rigidity are essential factors in determining the properties of individual molecules, the associated supramolecular assemblies, and bulk materials. This correlation is particularly important for π-conjugated molecular and macromolecular systems. Within such an individual molecule, a coplanar conformation facilitates the delocalization of not only molecular orbitals but also charges, excitons, and spins, leading to synergistically ensembled properties of the entire conjugated system. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00022DOI Listing

Symmetry-Breaking Synthesis of Multicomponent Nanoparticles.

Acc Chem Res 2019 Apr 3;52(4):1125-1133. Epub 2019 Apr 3.

State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science , Fudan University , Shanghai 200438 , P.R. China.

Multicomponent nanoparticles (MCNs) composed of disparate inorganic colloidal components have attracted great attention from researchers in both the academic and industrial community, because of their unique properties and diverse applications in energy conversion and storage; heterogeneous catalysis; optics and electronics; and biomedical imaging, diagnosis, and therapy. Compared with single-component nanoparticles (NPs), new or advanced properties of MCNs arise from the synergistic effect between their constituent components and the presence of nanoscale interfaces between distinct materials within the particles. Consequently, the spatial arrangement of nanoscale domains of MCNs becomes equally important in property or function control of MCNs as their size, shape, and composition, if not more. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00038DOI Listing

Water Disinfection in Rural Areas Demands Unconventional Solar Technologies.

Acc Chem Res 2019 Apr 3. Epub 2019 Apr 3.

Department of Chemical and Environmental Engineering and Nanosystems Engineering Research Center for Nanotechnology-Enabled Water Treatment (NEWT) , Yale University , New Haven , Connecticut 06511 , United States.

Providing access to safe drinking water is a prerequisite for protecting public health. Vast improvements in drinking water quality have been witnessed during the last century, particularly in urban areas, thanks to the successful implementation of large, centralized water treatment plants and the distribution of treated water via underground networks of pipes. Nevertheless, infection by waterborne pathogens through the consumption of biologically unsafe drinking water remains one of the most significant causes of morbidity and mortality in developing rural areas. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00578DOI Listing

Noncoded Amino Acids in de Novo Metalloprotein Design: Controlling Coordination Number and Catalysis.

Acc Chem Res 2019 Apr 1. Epub 2019 Apr 1.

Department of Chemistry , University of Michigan Ann Arbor , Michigan 48109 , United States.

The relationship between structure and function has long been one of the major points of investigation in Biophysics. Understanding how much, or how little, of a protein's often complicated structure is necessary for its function can lead to directed therapeutic strategies and would allow one to design proteins for specific desired functions. Studying protein function by de novo design builds the functionality from the ground up in a completely unrelated and noncoded protein scaffold. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00032DOI Listing

Hemoproteins Reconstituted with Artificial Metal Complexes as Biohybrid Catalysts.

Acc Chem Res 2019 Apr 1;52(4):945-954. Epub 2019 Apr 1.

Department of Applied Chemistry, Graduate School of Engineering , Osaka University , Suita , Osaka 565-0871 , Japan.

In nature, heme cofactor-containing proteins participate not only in electron transfer and O storage and transport but also in biosynthesis and degradation. The simplest and representative cofactor, heme b, is bound within the heme pocket via noncovalent interaction in many hemoproteins, suggesting that the cofactor is removable from the protein, leaving a unique cavity. Since the cavity functions as a coordination sphere for heme, it is of particular interest to investigate replacement of native heme with an artificial metal complex, because the substituted metal complex will be stabilized in the heme pocket while providing alternative chemical properties. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00676DOI Listing
April 2019
1 Read

Separation and Analysis of Microplastics and Nanoplastics in Complex Environmental Samples.

Acc Chem Res 2019 Apr 29;52(4):858-866. Epub 2019 Mar 29.

Department of Chemical Engineering , McGill University , 3610 University Street , Montréal , Québec H3A 0C5 , Canada.

The vast amount of plastic waste emitted into the environment and the increasing concern of potential harm to wildlife has made microplastic and nanoplastic pollution a growing environmental concern. Plastic pollution has the potential to cause both physical and chemical harm to wildlife directly or via sorption, concentration, and transfer of other environmental contaminants to the wildlife that ingest plastic. Small particles of plastic pollution, termed microplastics (>100 nm and <5 mm) or nanoplastics (<100 nm), can form through fragmentation of larger pieces of plastic. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.8b00602
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http://dx.doi.org/10.1021/acs.accounts.8b00602DOI Listing
April 2019
2 Reads

Going Viral: Emerging Opportunities for Phage-Based Bacterial Control in Water Treatment and Reuse.

Acc Chem Res 2019 Apr 29;52(4):849-857. Epub 2019 Mar 29.

Department of Civil and Environmental Engineering , Rice University , Houston , Texas 77005 , United States.

Water security to protect human lives and support sustainable development is one of the greatest global challenges of this century. While a myriad of water pollutants can impact public health, the greatest threat arises from pathogenic bacteria that can be harbored in different components of water treatment, distribution, and reuse systems. Bacterial biofilms can also promote water infrastructure corrosion and biofouling, which substantially increase the cost and complexity of many critical operations. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00576DOI Listing
April 2019
1 Read

The Surface of Ice under Equilibrium and Nonequilibrium Conditions.

Acc Chem Res 2019 Apr 29;52(4):1006-1015. Epub 2019 Mar 29.

Institute of Low Temperature Science , Hokkaido University , Sapporo 060-0819 , Japan.

The ice premelt, often called the quasi-liquid layer (QLL), is key for the lubrication of ice, gas uptake by ice, and growth of aerosols. Despite its apparent importance, in-depth understanding of the ice premelt from the microscopic to the macroscopic scale has not been gained. By reviewing data obtained using molecular dynamics (MD) simulations, sum-frequency generation (SFG) spectroscopy, and laser confocal differential interference contrast microscopy (LCM-DIM), we provide a unified view of the experimentally observed variation in quasi-liquid (QL) states. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00615DOI Listing

Formation of Iodinated Disinfection Byproducts (I-DBPs) in Drinking Water: Emerging Concerns and Current Issues.

Acc Chem Res 2019 Apr 28;52(4):896-905. Epub 2019 Mar 28.

Department of Chemistry and Biochemistry , University of South Carolina , Columbia , South Carolina 29208 , United States.

Formation of iodinated disinfection byproducts (I-DBPs) in drinking water has become an emerging concern. Compared to chlorine- and bromine-containing DBPs, I-DBPs are more toxic, have different precursors and formation mechanisms, and are unregulated. In this Account, we focus on recent research in the formation of known and unknown I-DBPs in drinking water. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00641DOI Listing

Photocrystallographic Studies on Transition Metal Nitrito Metastable Linkage Isomers: Manipulating the Metastable State.

Acc Chem Res 2019 Apr 27;52(4):1079-1088. Epub 2019 Mar 27.

Department of Chemistry , University of Bath , Bath BA2 7AY , U.K.

The design of solid-state materials whose properties and functions can be manipulated in a controlled manner by the application of light is an important objective in modern materials chemistry. When the material changes property or function, it is helpful if a simple measurable response, such as a change in color, can be detected. Potential applications for such materials are wide ranging, from data storage to smart windows. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00018DOI Listing
April 2019
1 Read

Triarylamine-Based Supramolecular Polymers: Structures, Dynamics, and Functions.

Acc Chem Res 2019 Apr 27;52(4):975-983. Epub 2019 Mar 27.

SAMS Research Group , University of Strasbourg, Institut Charles Sadron, CNRS , 23 rue du Loess , BP 84047, 67034 Cedex 2 Strasbourg , France.

Triarylamine molecules and triarylamine-based covalent polymers have been extensively investigated for more than 60 years in academics and industry because of their intriguing electronic and optical characteristics. However, despite the profusion of studies made on these derivatives, only very recently have the first examples of supramolecular polymers based on the triarylamine motif been described in the literature. Specifically, our research group has shown that, by adding supplementary hydrogen bonding moieties such as amide functions in their periphery, it becomes possible to tightly pack triarylamine molecules in columnar supramolecular stacks presenting a collinear arrangement of their central nitrogen atoms. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00536DOI Listing

Re-Engineering RNA Molecules into Therapeutic Agents.

Acc Chem Res 2019 Apr 26;52(4):1036-1047. Epub 2019 Mar 26.

Alnylam Pharmaceuticals , 300 Third Street , Cambridge , Massachusetts 02142 , United States.

Efforts to chemically modify nucleic acids got underway merely a decade after the discovery of the DNA double helix and initially targeted nucleosides and nucleotides. The origins of three analogues that remain staples of modification strategies and figure prominently in FDA-approved nucleic acid therapeutics can be traced to the 1960s: 2'-deoxy-2'-fluoro-RNA (2'-F RNA), 2'- O-methyl-RNA (2'- OMe RNA), and the phosphorothioates (PS-DNA/RNA). Progress in nucleoside phosphoramidite-based solid phase oligonucleotide synthesis has gone hand in hand with the creation of second-generation (e. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00650DOI Listing
April 2019
3 Reads

Understanding and Modulating Metalloenzymes with Unnatural Amino Acids, Non-Native Metal Ions, and Non-Native Metallocofactors.

Acc Chem Res 2019 Apr 26;52(4):935-944. Epub 2019 Mar 26.

Department of Chemistry and Center for Biophysics and Quantitative Biology , University of Illinois at Urbana-Champaign , Urbana , Illinois 61801 , United States.

Metalloproteins set the gold standard for performing important functions, including catalyzing demanding reactions under mild conditions. Designing artificial metalloenzymes (ArMs) to catalyze abiological reactions has been a major endeavor for many years, but most ArM activities are far below those of native enzymes, making them unsuitable for most pratical applications. A critical step to advance the field is to fundamentally understand what it takes to not only confer but also fine-tune ArM activities so they match those of native enzymes. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00011DOI Listing
April 2019
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Transition-Metal (Pd, Ni, Mn)-Catalyzed C-C Bond Constructions Involving Unactivated Alkyl Halides and Fundamental Synthetic Building Blocks.

Acc Chem Res 2019 Apr 25;52(4):1134-1144. Epub 2019 Mar 25.

Department of Chemistry , The University of North Carolina at Chapel Hill , Chapel Hill , North Carolina 27599 , United States.

The catalytic construction of C-C bonds between organohalide or pseudohalide electrophiles and fundamental building blocks such as alkenes, arenes, or CO are widely utilized metal-catalyzed processes. The use of simple, widely available unactivated alkyl halides in these catalytic transformations has significantly lagged behind the use of aryl or vinyl electrophiles. This difference is primarily due to the relative difficulty of activating alkyl halides with transition metals under mild conditions. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00044
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http://dx.doi.org/10.1021/acs.accounts.9b00044DOI Listing
April 2019
3 Reads

Enabling Multifunctional Organic Transistors with Fine-Tuned Charge Transport.

Acc Chem Res 2019 Apr 25;52(4):1113-1124. Epub 2019 Mar 25.

Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China.

Organic field-effect transistors (OFETs) are promising candidates for many electronic applications not only because of the intrinsic features of organic semiconductors in mechanical flexibility and solution processability but also owing to their multifunctionalities promised by combined signal switching and transduction properties. In contrast to rapid developments of high performance devices, the construction of multifunctional OFETs remains challenging. A key issue is fine-tuning the charge transport by modulating electric fields that are coupled with various external stimuli. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00031DOI Listing
April 2019
1 Read

Opportunities for Building-Scale Urine Diversion and Challenges for Implementation.

Acc Chem Res 2019 Apr 25;52(4):886-895. Epub 2019 Mar 25.

School of Sustainable Engineering and the Built Environment (SSEBE) , Arizona State University , PO Box 873005, Tempe , Arizona 85287-3005 , United States.

Urine diversion (i.e., urine source separation) has been proposed as a more sustainable solution for water conversation, nutrient removal and recovery, and pharmaceutical sequestration. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00614DOI Listing
April 2019
1 Read

Nanomaterial-Supported Enzymes for Water Purification and Monitoring in Point-of-Use Water Supply Systems.

Acc Chem Res 2019 Apr 22;52(4):876-885. Epub 2019 Mar 22.

Department of Civil and Environmental Engineering , University of California , Los Angeles , California 90095 , United States.

Increasing pollution of global water sources and challenges in rapid detection and treatment of the wide range of contaminants pose considerable burdens on public health. The issue is particularly critical in rural areas, where building of centralized water treatment systems and pipe infrastructure to connect dispersed populations is not always practical. Point-of-use (POU) water supply systems provide cost-effective and energy-efficient approaches to store, treat, and monitor the quality of water. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00613DOI Listing

On Controllability and Applicability of Surface Molecular Self-Assemblies.

Acc Chem Res 2019 Apr 21;52(4):1048-1058. Epub 2019 Mar 21.

BNLMS, College of Chemistry and Molecular Engineering , Peking University , Beijing 100871 , China.

Molecular self-assembly (MSA) refers to spontaneous arrangement of molecular building blocks into ordered structures governed by weak interactions. Due to its high versatility and reversibility, MSA has been widely employed as a robust bottom-up approach to fabricating low-dimensional functional nanostructures, which are used in various applications in nanoscience and technology. To date, tremendous effort has been devoted to constructing various MSAs at surfaces, ranging from self-assembled monolayers and two-dimensional (2D) nanoporous networks to complex 2D quasicrystals and Sierpiński triangle fractals. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00002DOI Listing

Organic Synapses for Neuromorphic Electronics: From Brain-Inspired Computing to Sensorimotor Nervetronics.

Acc Chem Res 2019 Apr 21;52(4):964-974. Epub 2019 Mar 21.

Living organisms have a long evolutionary history that has provided them with functions and structures that enable them to survive in their environment. The goal of biomimetic technology is to emulate these traits of living things. Research in bioinspired electronics develops electronic sensors and motor systems that mimic biological sensory organs and motor systems and that are intended to be used in bioinspired applications such as humanoid robots, exoskeletons, and other devices that combine a living body and an electronic device. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00553DOI Listing
April 2019
1 Read

Hoodwinking Cytochrome P450BM3 into Hydroxylating Non-Native Substrates by Exploiting Its Substrate Misrecognition.

Acc Chem Res 2019 Apr 19;52(4):925-934. Epub 2019 Mar 19.

Research Center for Materials Science , Nagoya University, Furo-cho , Chikusa-ku , Nagoya 464-8602 , Japan.

Bacterial cytochrome P450s (P450s) are at the focus of attention as potential biocatalysts for applications in green synthetic chemistry, as they possess high activity for the hydroxylation of inert substrate C-H bonds. The high activity of bacterial P450s, such as P450BM3, is chiefly due to their high substrate specificity, and consequently, the catalytic activity of P450BM3 toward non-native substrates is very low, limiting the utility of bacterial P450s as biocatalysts. To enable oxidation of non-native substrates by P450BM3 without any mutagenesis, we have developed a series of "decoy molecules", inert dummy substrates, with structures that resemble those of the native substrates. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00651DOI Listing

Wearable Bioelectronics: Opportunities for Chemistry.

Acc Chem Res 2019 Mar;52(3):521-522

Seoul National University.

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http://dx.doi.org/10.1021/acs.accounts.9b00048DOI Listing

Microporous Metal-Organic Frameworks for Adsorptive Separation of C5-C6 Alkane Isomers.

Authors:
Hao Wang Jing Li

Acc Chem Res 2019 Mar 18. Epub 2019 Mar 18.

Hoffmann Institute of Advanced Materials , Shenzhen Polytechnic , 7098 Liuxian Boulevard , Shenzhen 518055 , China.

The separation of alkane isomers, particularly C5-C6 alkanes, is of paramount importance in the petrochemical industry to achieve high quality gasoline. Upon catalytic isomerization reactions, less branched alkanes (with lower octane number) need to be separated from their more branched isomers (with higher octane number) in order to improve the octane rating of gasoline. To reduce the high energy input associated with distillations, the primary separation technique currently used in industry, adsorptive separation by porous solids has been proposed. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00658DOI Listing
March 2019
2 Reads

Molecular Assembly of Rotary and Linear Motor Proteins.

Authors:
Yi Jia Junbai Li

Acc Chem Res 2019 Mar 18. Epub 2019 Mar 18.

Beijing National Laboratory for Molecular Sciences, CAS Key Lab of Colloid, Interface and Chemical Thermodynamics , Institute of Chemistry, Chinese Academy of Sciences , Beijing 100190 , China.

Molecular machines are an important and emerging frontier in research encompassing interdisciplinary subjects of chemistry, physics, biology, and nanotechnology. Although there has been major interest in creating synthetic molecular machines, research on natural molecular machines is also crucial. Biomolecular motors are natural molecular machines existing in nearly every living systems. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00015DOI Listing

Carbon Nanodots for Charge-Transfer Processes.

Acc Chem Res 2019 Apr 18;52(4):955-963. Epub 2019 Mar 18.

Department of Chemistry and Pharmacy & Interdisciplinary Center for Molecular Materials , Friedrich-Alexander-University Erlangen-Nürnberg , Egerlandstrasse 4 , 91058 Erlangen , Germany.

In recent years, carbon nanodots (CNDs) have emerged as an environmentally friendly, biocompatible, and inexpensive class of material, whose features sparked interest for a wide range of applications. Most notable is their photoactivity, as exemplified by their strong luminescence. Consequently, CNDs are currently being investigated as active components in photocatalysis, sensing, and optoelectronics. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00673DOI Listing
April 2019
1 Read

Energies of Adsorbed Catalytic Intermediates on Transition Metal Surfaces: Calorimetric Measurements and Benchmarks for Theory.

Acc Chem Res 2019 Apr 17;52(4):984-993. Epub 2019 Mar 17.

Department of Chemistry , University of Washington , Seattle , Washington 98195-1700 , United States.

Better catalysts and electrocatalysts are essential for the production and use of clean fuels with less pollution and improved energy efficiency, for making chemicals with less energy and environmental impact, for pollution abatement, and for many other future technologies needed to achieve environmentally friendlier energy supply and chemicals industry. Crucial for rational design of better catalyst and electrocatalyst materials is knowledge of the energies of elementary chemical reactions on late transition metal surfaces. This knowledge would also aid in designing more efficient and stable photocatalysts and batteries for harvesting and storing solar energy. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00579DOI Listing
April 2019
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Conjugated Macrocycles in Organic Electronics.

Acc Chem Res 2019 Apr 14;52(4):1068-1078. Epub 2019 Mar 14.

Department of Chemistry , Columbia University , New York , New York 10027 , United States.

This Account describes a body of research on the design, synthesis, and application of a new class of electronic materials made from conjugated macrocycles. Our macrocyclic design takes into consideration the useful attributes of fullerenes and what properties make fullerenes efficient n-type materials. We identified four electronic and structural elements: (1) a three-dimensional shape; (2) a conjugated and delocalized π-space; (3) the presence of an interior and exterior to the π-surface; and (4) low-energy unoccupied molecular orbitals allowing them to accept electrons. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00017
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http://dx.doi.org/10.1021/acs.accounts.9b00017DOI Listing
April 2019
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Smart Patterned Surface with Dynamic Wrinkles.

Acc Chem Res 2019 Apr 14;52(4):1025-1035. Epub 2019 Mar 14.

School of Chemistry & Chemical Engineering, State Key Laboratory for Metal Matrix Composite Materials , Shanghai Jiao Tong University , Shanghai 200240 , People's Republic of China.

Patterned surfaces are fundamentally important to physics, chemistry, materials, and biology science, endowing significant functions and thus bearing broad and fantastic applications whether in natural or man-made events. Among the various methods for patterning surfaces, wrinkling or buckling offers a powerful alternative to prepare surface patterns because of its spontaneous nature, versatility, easy preparation in large-scale, and capability to be responsive to various stimuli. In particular, patterned surfaces with dynamic wrinkles can tailor the encoded surface properties on demand and can provide a promising alternative for smart surfaces, which has potential for wide applications in enhanced and tunable optical or photoelectric devices, responsive microstructures, switchable wettability, smart adhesion and friction, and so on. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00623DOI Listing

A Tale of Two Water Supplies in China: Finding Practical Solutions to Urban and Rural Water Supply Problems.

Acc Chem Res 2019 Apr 13;52(4):867-875. Epub 2019 Mar 13.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment , Tsinghua University , Beijing , China 100084.

Access to safe drinking water is among the 17 United Nations sustainable development goals. As the largest developing country, China has confronted large challenges to providing safe and sufficient drinking water to its population of 1.4 billion under the conditions of limited water sources and ubiquitous water contamination. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00605DOI Listing

Study of G-Protein Coupled Receptor Signaling in Membrane Environment by Plasmon Waveguide Resonance.

Acc Chem Res 2019 Apr 13;52(4):1059-1067. Epub 2019 Mar 13.

CBMN UMR 5248 CNRS, University of Bordeaux, Bat. B14 allée Geoffroy St. Hilaire , 33600 Pessac , France.

Here we describe an experimental technique, termed plasmon waveguide resonance (PWR) spectroscopy that enables the characterization of molecular interactions occurring at the level of anisotropic thin films as lipid membranes and therein inserted or interacting molecules. PWR allows one to characterize such molecular interactions at different levels: (1) acquire binding curves and calculate dissociation constants; (2) obtain kinetic information; (3) obtain information about associated anisotropy changes and changes in membrane thickness; (4) obtain insight about lateral homogeneity (formation of domains). Points 1, 2, and 4 can be directly obtained from the data. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00007DOI Listing

Differential Drivers of Antimicrobial Resistance across the World.

Acc Chem Res 2019 Apr 8;52(4):916-924. Epub 2019 Mar 8.

Department of Civil and Environmental Engineering , Virginia Tech , Blacksburg , Virginia 24061 , United States.

Antimicrobial resistance (AMR) is one of the greatest threats faced by humankind. The development of resistance in clinical and hospital settings has been well documented ever since the initial discovery of penicillin and the subsequent introduction of sulfonamides as clinical antibiotics. In contrast, the environmental (i. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00643DOI Listing
April 2019
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P-Chiral Phosphorus Ligands Based on a 2,3-Dihydrobenzo[ d][1,3]oxaphosphole Motif for Asymmetric Catalysis.

Acc Chem Res 2019 Apr 8;52(4):1101-1112. Epub 2019 Mar 8.

State Key Laboratory of Bio-Organic & Natural Products Chemistry, Center for Excellence in Molecular Synthesis , Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences , 345 Ling Ling Road , Shanghai 200032 , P. R. China.

Despite the rapid progress in the field of asymmetric catalysis, the search for new, efficient, and practical asymmetric catalytic transformations to facilitate the green synthesis of chiral natural products and drugs will continue to be a major ongoing effort in organic chemistry. Chiral phosphorus ligands have played a significant role in recent advances in transition-metal-catalyzed asymmetric transformations. However, there remain numerous challenging issues of reactivity and selectivity in catalysis. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00029DOI Listing
April 2019
11 Reads

Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination.

Acc Chem Res 2019 Mar 7;52(3):818-832. Epub 2019 Mar 7.

Department of Biochemistry and Molecular Pharmacology , UMass Medical School , 364 Plantation Street , Worcester , Massachusetts 01605 , United States.

Proteins are well-known to undergo a variety of post-translational modifications (PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group of hydrolases called protein arginine deiminases (PADs). Hundreds of proteins are known to be citrullinated and hypercitrullination is associated with autoimmune diseases including rheumatoid arthritis (RA), lupus, ulcerative colitis (UC), Alzheimer's disease, multiple sclerosis (MS), and certain cancers. Read More

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http://pubs.acs.org/doi/10.1021/acs.accounts.9b00024
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http://dx.doi.org/10.1021/acs.accounts.9b00024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443095PMC
March 2019
4 Reads

Asymmetric Photocatalysis with Bis-cyclometalated Rhodium Complexes.

Acc Chem Res 2019 Mar 6;52(3):833-847. Epub 2019 Mar 6.

Fachbereich Chemie , Philipps-Universität Marburg , Hans-Meerwein Straße 4 , 35043 Marburg , Germany.

Aspects of sustainability are playing an increasingly important role for the development of new synthetic methods. In this context, the combination of asymmetric catalysis, which is considered one of the most economic strategies to generate nonracemic chiral compounds, and visible light as an abundant source of energy to induce or activate chemical reactions has recently gained much attention. Furthermore, the combination of photochemistry with asymmetric catalysis provides new opportunity for the development of mechanistically unique reaction schemes. Read More

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http://dx.doi.org/10.1021/acs.accounts.9b00028DOI Listing
March 2019
2 Reads

Material-Independent Surface Chemistry beyond Polydopamine Coating.

Acc Chem Res 2019 Mar 5;52(3):704-713. Epub 2019 Mar 5.

Department of Chemistry , Korea Advanced Institute of Science and Technology (KAIST) , 291 University Road , Daejeon 34141 , South Korea.

Various methods have been developed in surface chemistry to control interface properties of a solid material. A selection rule among surface chemistries is compatibility between a surface functionalization tool and a target material. For example, alkanethiol deposition on noble metal surfaces, widely known as the formation of a self-assembled monolayer (SAM), cannot be performed on oxide material surfaces. Read More

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http://dx.doi.org/10.1021/acs.accounts.8b00583DOI Listing
March 2019
3 Reads