89,260 results match your criteria Accounting Horizons[Journal]


Identification and expression of a novel heterozygous frameshift mutation in FGA accounting for congenital hypofibrinogenemia in carriers of severe hemophilia A.

Thromb Res 2020 May 28;193:5-8. Epub 2020 May 28.

Department of Genetic Medicine and Development, University of Geneva Faculty of Medicine, Switzerland; iGE3, Institute of Genetics and Genomics in Geneva, Geneva, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2020.05.040DOI Listing

The moving of high emission for biomass burning in China: View from multi-year emission estimation and human-driven forces.

Environ Int 2020 Jun 1;142:105812. Epub 2020 Jun 1.

Department of Environmental Science and Technology, School of Environmental Studies, China University of Geosciences, Wuhan 430074, China; State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan 430074, China. Electronic address:

Biomass burning (BB) has significant impacts on air quality, climate and human health. In China, the BB emission has changed substantially over the past decades while the multi-year variation held high uncertainty and the driving forces have addressed little attention. Here, this research aimed to conduct a comprehensive and systematic analysis of BB variation in China and provided precise and targeted BB emission reduction suggestions. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105812DOI Listing

Production of volatile fatty acids through co-digestion of sewage sludge and external organic waste: Effect of substrate proportions and long-term operation.

Waste Manag 2020 Jun 1;112:30-39. Epub 2020 Jun 1.

Department of Chemical Engineering, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden. Electronic address:

Volatile fatty acids (VFAs) are intermediates of anaerobic digestion with high value and wide range of usage. Co-digestion of sewage sludge and external organic waste (OW) for VFA production can help achieve both resource recovery and ensure sustainable and innovative waste management. In view of this, the effect of substrate proportions on VFA production from co-digestion of primary sewage sludge and OW is studied. Read More

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http://dx.doi.org/10.1016/j.wasman.2020.05.027DOI Listing

Functional PVDF ultrafiltration membrane for Tetrabromobisphenol-A (TBBPA) removal with high water recovery.

Water Res 2020 May 18;181:115952. Epub 2020 May 18.

Faculty of Engineering and Applied Science, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada; Institute for Energy, Environment and Sustainable Communities, University of Regina, Regina, Saskatchewan, S4S 0A2, Canada.

Tetrabromobisphenol-A (TBBPA) is one of the most important brominated flame retardants (BFRs), accounting for 60% of the total commercial BFR market. Increasing amounts of TBBPA and byproducts are released to the aquatic environment due to their extensive utilization in various sectors. However, research on the treatment of TBBPA contaminated wastewater using membrane filtration is still lacked. Read More

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http://dx.doi.org/10.1016/j.watres.2020.115952DOI Listing

Fetal heart rate pattern in term or near-term cerebral palsy: A nationwide cohort study.

Am J Obstet Gynecol 2020 Jun 1. Epub 2020 Jun 1.

The Recurrence Prevention Committee, Japan Obstetric Compensation System for Cerebral Palsy, Public Interest Incorporated Foundation Japan Council for Quality Health Care, Tokyo, Japan; Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, Mie, Japan.

Background: It is crucial to interpret the fetal heart rate pattern with a focus on the pattern evolution during labor to estimate the relationship between cerebral palsy and delivery. However, nationwide data are lacking.

Objective: The aim of our study was to demonstrate the features of fetal heart rate pattern evolution and estimate the timing of fetal brain injury during labor in cerebral palsy cases. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.059DOI Listing

Making the most of population genomic data to understand the importance of chromosomal inversions for adaptation and speciation.

Authors:
Claire Mérot

Mol Ecol 2020 Jun 4. Epub 2020 Jun 4.

Institut de Biologie Intégrative et des Systèmes (IBIS), Université Laval, Québec City, Québec, Canada.

Chromosomal inversions are increasingly found to differentiate locally-adapted populations. This adaptive role is predictable because reduced recombination protects allelic combinations from gene flow. However, we are far from understanding how frequently inversions contribute to local adaptation and how widespread this phenomenon is across species. Read More

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http://dx.doi.org/10.1111/mec.15500DOI Listing

Obesity, race, and long-term prostate cancer outcomes.

Cancer 2020 Jun 4. Epub 2020 Jun 4.

Urology Section, Department of Surgery, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.

Background: The authors previously found that obesity was linked with prostate cancer (PC)-specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association between obesity and long-term PC outcomes, including PCSM, differed by race.

Methods: Data from 5929 patients who underwent RP and were in the Shared Equal Access Regional Cancer Hospital (SEARCH) database were analyzed. Read More

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http://dx.doi.org/10.1002/cncr.32906DOI Listing

Incarceration And Its Disseminations: COVID-19 Pandemic Lessons From Chicago's Cook County Jail.

Health Aff (Millwood) 2020 Jun 4:101377hlthaff202000652. Epub 2020 Jun 4.

Daniel Chen is Directeur de Recherche at the Centre National de la Recherche Scientifique (CNRS), in Paris, France; a professor at the Toulouse School of Economics and Université de Toulouse Faculty of Law, in Toulouse, France; and lead principal investigator of the DE JURE (Data and Evidence for Judicial Reform) Program at the World Bank in Washington, D.C.

Jails and prisons are major sites of novel coronavirus (SARS-CoV-2) infection. Many jurisdictions in the United States have therefore accelerated release of low-risk offenders. Early release, however, does not address how arrest and pre-trial detention practices may be contributing to disease spread. Read More

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http://dx.doi.org/10.1377/hlthaff.2020.00652DOI Listing

Factorial Structure and Nomological Network of the Inventory of Callous-Unemotional Traits Accounting for Item Keying Variance.

J Pers Assess 2020 Jun 4:1-12. Epub 2020 Jun 4.

Department of Psychology, University of Cyprus, Nicosia, Cyprus.

The factorial structure of the Inventory of Callous Unemotional Traits (ICU) is currently under dispute. The present study aims to test the factorial structure of a Greek adaptation of the ICU by considering item keying variance and examining alternative theoretical and empirically derived models. Additionally, it aims to investigate the nomological network of the ICU subscales, after controlling for item keying variance. Read More

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http://dx.doi.org/10.1080/00223891.2020.1769112DOI Listing

Does time from diagnosis to treatment affect the prognosis of patients with newly diagnosed acute myeloid leukemia?

Blood 2020 Jun 4. Epub 2020 Jun 4.

University Hospital Dresden, Dresden, Germany.

In fit patients with newly diagnosed acute myeloid leukemia (AML), immediate treatment start is recommended due to the poor prognosis of untreated acute leukemia. We explored the relationship between the time from diagnosis to treatment start (TDT) and prognosis in a large set of real-world data from the German SAL-AML registry. All registered non-APL patients from the registry with intensive induction treatment and a minimum follow-up time of 12 months were selected (n=2,263). Read More

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http://dx.doi.org/10.1182/blood.2019004583DOI Listing

Outcome of Core Binding Factor Acute Myeloid Leukemia in Children: A Single-Center Experience.

J Pediatr Hematol Oncol 2020 Jun 2. Epub 2020 Jun 2.

The Indus Hospital.

Childhood acute myeloid leukemia (AML) harboring core binding factor (CBF)-associated translocations are considered as a favorable cytogenetic subgroup. The 2 major subtypes of CBF-AML include t(8;21) and inversion of chromosome 16, accounting for ∼25% of patients. Because of expensive and toxic treatment, which may require hospitalization during the entire course of induction chemotherapy, most of the centers in Pakistan neither workup for this low-risk entity nor offer curative treatment. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001853DOI Listing

A Propensity Score-weighted Comparison of Outcomes Between Living and Standard Criteria Deceased Donor Kidney Transplant Recipients.

Transplantation 2020 Jun 1. Epub 2020 Jun 1.

ICES, London, Ontario, Canada.

Background: Consider a theoretical situation in which 2 patients with similar baseline characteristics receive a kidney transplant on the same day: 1 from a standard criteria deceased donor, the other from a living donor. Which kidney transplant will last longer?

Methods: We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada from January 1, 2005 to March 31, 2014 to evaluate several posttransplant outcomes in individuals who received a kidney transplant from a standard criteria deceased donor (n=1523) or from a living donor (n=1373). We used propensity-score weighting using overlap weights, a novel weighting method that emphasizes the population of recipients with the most overlap in baseline characteristics. Read More

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http://dx.doi.org/10.1097/TP.0000000000003337DOI Listing

Detouring in the family system as an antecedent of children's adjustment problems.

J Fam Psychol 2020 Jun 4. Epub 2020 Jun 4.

Department of Psychology.

Guided by conceptualizations of relational boundaries from family systems theory, this study examined unique links between detouring (e.g., alliance between parents against child) and young children's psychological functioning after accounting for general family negativity and conflict. Read More

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http://dx.doi.org/10.1037/fam0000727DOI Listing

Strength of niche processes for species interactions is lower for generalists and exotic species.

J Anim Ecol 2020 Jun 4. Epub 2020 Jun 4.

Centre for Integrative Ecology, School of Biological Sciences, University of Canterbury, Christchurch, New Zealand.

Niche and neutral processes jointly influence species interactions. Predictions of interactions based on these processes assume that they operate similarly across all species. However, species characteristics could systematically create differences in the strength of niche or neutral processes for each interspecific interaction. Read More

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http://dx.doi.org/10.1111/1365-2656.13274DOI Listing

Caffeinated Coffee and Tea Consumption, Genetic Variation and Cognitive Function in the UK Biobank.

J Nutr 2020 Jun 4. Epub 2020 Jun 4.

Rush Institute for Healthy Aging, Rush University, Chicago, IL, USA.

Background: Coffee and tea are the major contributors of caffeine in the diet. Evidence points to the premise that caffeine may benefit cognition.

Objective: We examined the associations of habitual regular coffee or tea and caffeine intake with cognitive function whilst additionally accounting for genetic variation in caffeine metabolism. Read More

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http://dx.doi.org/10.1093/jn/nxaa147DOI Listing

[Analysis of adverse drug reaction/adverse event and early warning signal mining of Ginkgo biloba Dropping Pills based on SRS data].

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2322-2328

School of Statistics, Renmin University of China Beijing 100872, China.

In order to understand the characteristics of adverse drug reaction/adverse event(ADR/AE) of Ginkgo biloba Dropping Pills and evaluate the safety of clinical use after marketing, 407 ADR/AE case report data of Ginkgo biloba Dropping Pills collected by National Center for ADR Monitoring System during 2009-2018 was systematically analyzed, and its general characteristics were analyzed using descriptive statistical methods. The results showed that among the 407 cases of spontaneous reporting system(SRS) data, 401 cases were general ADR/AE, accounting for 98.5%, and 6 cases were severe ADR/AE, accounting for 1. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200221.502DOI Listing

[Analysis of adverse reactions of Xianling Gubao preparation based on real world SRS data].

Zhongguo Zhong Yao Za Zhi 2020 May;45(10):2316-2321

School of Statistics, Renmin University of China Beijing 100872, China.

From January 1, 2004 to July 21, 2016 a total of 2 796 cases of adverse drug reaction/adverse event(ADR/AE) after the use of Xianling Gubao Capsules/Tablets were reported by National Adverse Drug Reaction Monitoring Center. The following results were obtained by analyzing the reports of 2 796 cases of adverse drug reactions/adverse drug events after the use of Xianling Gubao Capsules/Tablets. A total of 75 patients, accounting for 2. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20200211.505DOI Listing

Four pediatric cases of secondary neoplasms arising in nevus sebaceous.

Dermatol Ther 2020 Jun 3:e13762. Epub 2020 Jun 3.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center For Children's Health, Beijing, China.

Secondary neoplasms of epidermal adnexal origin have been reported to develop into nevus sebaceous(NS), mainly in adulthood but rarely in children. Four cases of secondary neoplasms were identified in 413 children of nevus sebaceous from 2015 to 2019 by our department, accounting for 1% of all cases. We here report the clinical, dermoscopical and histopathological features of these tumors, including syringocystadenoma papilliferum(SCAP), pilomatricoma, trichilemmoma and basal cell carcinoma(BCC). Read More

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http://dx.doi.org/10.1111/dth.13762DOI Listing

microRNA-124-3p inhibits tumourigenesis by targeting mitogen-activated protein kinase 4 in papillary thyroid carcinoma.

Cell Biochem Funct 2020 Jun 3. Epub 2020 Jun 3.

Department of Gastroenterology, Cangzhou Central Hospital, Cangzhou, Hebei, China.

The study aimed to investigate the role of miR-124-3p and its potential molecular mechanism in papillary thyroid cancer (PTC). The expression of miR-124-3p and mitogen-activated protein kinase 4 (MAP2K4) in human thyroid follicular epithelial cell line (NTHY-ORI3-1) and human papillary thyroid carcinoma cell lines (SW1736, BCPAP, TPC-1 and K1) was measured by RT-qPCR. Cell proliferation was measured by CCK-8, while cell cycle and apoptosis rate were measured by flow cytometry. Read More

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http://dx.doi.org/10.1002/cbf.3532DOI Listing

Learning curve in robotic transabdominal preperitoneal (rTAPP) ventral hernia repair: a cumulative sum (CUSUM) analysis.

Hernia 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgery, University of Massachusetts Medical School, Worcester, MA, USA.

Purpose: rTAPP-VHR is a novel technique which may be added to a surgeon's armamentarium. We aim to evaluate the robotic transabdominal preperitoneal ventral hernia repair (rTAPP-VHR) learning curve based on operative times while accounting for peritoneal flap integrity.

Methods: We performed a retrospective analysis of a database collected over a 7-year period. Read More

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http://dx.doi.org/10.1007/s10029-020-02228-0DOI Listing

Trans-obturator cystocele repair of level 2 paravaginal defect.

Int Urogynecol J 2020 Jun 3. Epub 2020 Jun 3.

Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.

Introduction And Hypothesis: It is reported that almost one in five women will need some form of pelvic organ prolapse surgery in their lifetime, with anterior wall repair accounting for nearly half of these. Cystoceles occur secondary to defect(s) in one or more of the vaginal wall support mechanisms, including its lateral paravaginal attachments. Paravaginal defects are very common in women presenting with cystocele, thus highlighting the importance of paravaginal defect repair for optimal cystocele correction in the majority of cases. Read More

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http://dx.doi.org/10.1007/s00192-020-04337-xDOI Listing

Levels of Perfluoroalkyl Acids (PFAAs) in Human Serum, Hair and Nails in Guangdong Province, China: Implications for Exploring the Ideal Bio-Indicator.

Arch Environ Contam Toxicol 2020 Jun 3. Epub 2020 Jun 3.

College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.

The widespread human exposure to perfluoroalkyl acids (PFAAs) has led to increasing public concern. In this study, we present a comprehensive measurement of total fluorine (TF), extractable organic fluorine (EOF), identified organic fluorine (IOF, total concentration of identified PFAAs quantified as fluorine) and 11 target PFAAs in human serum (n = 60), hair (n = 49) and nails (n = 39) collected from non-occupation exposed volunteers in 10 cities of Guangdong Province, China. The results indicated that EOF was the major form of fluorine in serum, accounting for 70-80% of TF. Read More

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http://dx.doi.org/10.1007/s00244-020-00743-wDOI Listing

Multibody Analysis and Control of a Full-Wrist Exoskeleton for Tremor Alleviation.

J Biomech Eng 2020 Jun 4. Epub 2020 Jun 4.

Department of Mechanical Engineering, Virginia Tech, Blacksburg, Virginia 24061, USA.

Uncontrollable shaking in the human wrist, caused by pathological tremor, can significantly undermine the power and accuracy in object manipulation. In this paper, the design of a Tremor Alleviating Wrist Exoskeleton (TAWE) is introduced. Unlike the works in the literature that only consider the flexion/extension motion, in this paper, we model the wrist joint as a constrained 3D rotational joint accounting for the coupled flexion/extension (FE) and radial/ulnar deviation (RUD) motions. Read More

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http://dx.doi.org/10.1115/1.4047424DOI Listing

Update on cystine stones: current and future concepts in treatment.

Intractable Rare Dis Res 2020 May;9(2):71-78

Clinic of Dermatology, Dr. Brinkmann, Schult & Samimi-Fard. Gladbeck, Germany.

Cystine stones are relatively uncommon compared with other stone compositions, constituting just 1% to 2% of adult urinary tract stone diseases, and accounting for up to 10% of pediatric stone diseases. Two responsible genes of cystinuria have been identified, the SLC3A1 and the SLC7A9. Cystinuria is diagnosed by family history, stone analysis, or by measurement of urine cystine excretion. Read More

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http://dx.doi.org/10.5582/irdr.2020.03006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263987PMC

Economic burden of smoking-attributable diseases in China: A systematic review.

Tob Induc Dis 2020 12;18:42. Epub 2020 May 12.

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Introduction: This review aims to synthesise the studies on smoking-attributable burden of diseases in China to assess the economic burden of smoking and highlight the weakness in these studies to inform future studies.

Methods: A systematic search of studies on smoking-attributable burden of disease in seven databases was conducted in 2019 and studies were screened according to inclusion and exclusion criteria. The evaluation of studies was based on the seven key elements for burden of disease studies. Read More

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http://dx.doi.org/10.18332/tid/120102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263360PMC

Accounting for the dissipation of abiotic resources in LCA: Status, key challenges and potential way forward.

Resour Conserv Recycl 2020 Jun;157:104748

European Commission, Joint Research Centre, Via Enrico Fermi 2749, I-21027, Ispra, VA, Italy.

The concept of resources or materials dissipation after their use in the technosphere has been increasingly considered in life-cycle based studies, applying Substance and Material Flow Analysis (SFA and MFA), Input-Output Analysis, and Life Cycle Assessment (LCA). However, there is currently no common understanding of what a dissipative flow is. This article first reviews 45 publications to describe the status of resource dissipation in life-cycle based studies, discussing how resource dissipation is usually defined, which temporal perspective is considered, which compartments of dissipation are distinguished, and which approaches (including the implementation of parameters) are considered to assess resource dissipation in a system. Read More

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http://dx.doi.org/10.1016/j.resconrec.2020.104748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224519PMC

Suramin and NF449 are IP5K inhibitors that disrupt IP6-mediated regulation of cullin RING ligase and sensitize cancer cells to MLN4924/pevonedistat.

J Biol Chem 2020 Jun 3. Epub 2020 Jun 3.

Biology, Southern University of Science and Technology, China.

Inositol hexakisphosphate (IP6) is an abundant metabolite synthesized from inositol 1,3,4,5,6-pentakisphosphate [Ins(1,3,4,5,6)P5, or IP5] by the single Ins(1,3,4,5,6)P5 2-kinase (IP5K/IPPK). Genetic and biochemical studies have shown that IP6 usually functions as a structural cofactor in protein(s) mediating mRNA export, DNA repair, necroptosis, 3D genome organization, HIV infection, and cullin RING ligase (CRL) deneddylation. However, it remains unknown whether pharmacological perturbation of cellular IP6 levels affects any of these processes. Read More

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http://dx.doi.org/10.1074/jbc.RA120.014375DOI Listing

Penile prosthesis surgery: Indications and penoscrotal approach.

Authors:
P Vendeira

Actas Urol Esp 2020 May 31. Epub 2020 May 31.

Unidade de Urologia/Andrologia, Saúde Atlântica, Clínica do Dragão, Oporto, Portugal. Electronic address:

Inflatable penile prosthesis was developed in 1973 as a definitive treatment for erectile dysfunction. Since then these prosthetic devices underwent huge modifications, and scientific and technologic advances were accomplished, improving reliability, longevity and the surgical outcomes. Surgical implantation of a penile prosthesis may be considered in patients with erectile dysfunction who do not respond to pharmacotherapy or who prefer a permanent solution to their problem. Read More

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http://dx.doi.org/10.1016/j.acuro.2020.01.010DOI Listing

Identifying disparities in patient-centered care experiences between non-Latino white and black men: results from the 2008-2016 Medical Expenditure Panel Survey.

BMC Health Serv Res 2020 Jun 3;20(1):495. Epub 2020 Jun 3.

Institute of Gerontology, Wayne State University, Detroit, MI, USA.

Background: Patient-centered healthcare in the context of a medical home (PCMH) is an important pathway to reducing healthcare inequities. To date, no work has examined the prevalence of care experiences associated with PCMH among non-elderly Black males.

Methods: We analyzed data, on 22 indicators representative of six healthcare domains associated with PCMH experiences, from non-Latino White (NLW) and Black males aged 18-64 from the 2008-2016 Medical Expenditure Panel Survey (n = 47,405). Read More

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http://dx.doi.org/10.1186/s12913-020-05357-5DOI Listing

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.

Mol Cancer 2020 Jun 3;19(1):101. Epub 2020 Jun 3.

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Xinzao, Panyu District, Guangzhou, 511436, People's Republic of China.

Background: Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required. Circular RNAs have been reported to participate in the occurrence and progression of cancer. Read More

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http://dx.doi.org/10.1186/s12943-020-01221-6DOI Listing

Health and Economic Impacts of the National Menu Calorie Labeling Law in the United States.

Circ Cardiovasc Qual Outcomes 2020 Jun 4:CIRCOUTCOMES119006313. Epub 2020 Jun 4.

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (J.L., D.M., Y.L., P.E.W., R.M.).

Background: Excess caloric intake is linked to weight gain, obesity, and related diseases, including type 2 diabetes mellitus and cardiovascular disease (CVD). Obesity incidence is rising, with nearly 3 in 4 US adults being overweight or obese. In 2018, the US federal government finalized the implementation of mandatory labeling of calorie content on all menu items across major chain restaurants nationally as a strategy to support informed consumer choice, reduce caloric intake, and potentially encourage restaurant reformulations. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.119.006313DOI Listing

Tools for Open Source, Subnational CGE Modeling with an Illustrative Analysis of Carbon Leakage.

J Glob Econ Anal 2019 ;4(2)

National Center for Environmental Economics, U.S. EPA, 1200 Pennsylvania Avenue, N.W., Washington, DC 20460, USA.

This paper introduces the Wisconsin National Data Consortium (WiNDC) framework for producing self-consistent accounts based on publicly available datasets that can be used in sub-national economic equilibrium analysis in the United States. We describe the process used to generate regional social accounting matrices and a calibrated static multi-regional, multi-sectoral computable general equilibrium model conformal with the constructed dataset. As illustration, we show how the core model can be applied for the analysis of energy-environment issues. Read More

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http://dx.doi.org/10.21642/jgea.040201afDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266100PMC
January 2019

[Primary aldosteronism - why is it still underdiagnosed in clinical practice?]

Dtsch Med Wochenschr 2020 Jun 3;145(11):716-721. Epub 2020 Jun 3.

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München.

Primary aldosteronism (PA) represents the leading cause of endocrine hypertension, accounting for 4-13 % of all cases. Simultaneously, it is the most common endocrine form of hypertension that can be cured by surgery. Estimates suggest that 2. Read More

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http://dx.doi.org/10.1055/a-0958-0068DOI Listing

Primary Care Accessibility Effects on Health Care Utilization among Urban Children.

Acad Pediatr 2020 May 31. Epub 2020 May 31.

Applied Clinical Research Center, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104. Electronic address:

Objectives: Evidence suggests that spatial accessibility to primary care is a contributing factor to appropriate health care utilization, with limited primary care access resulting in avoidable hospitalizations and emergency department visits which are burdensome on individuals and our healthcare system. Limited research, however, has examined the effects on children.

Methods: We evaluated associations of spatial accessibility to primary care on health care utilization among a sample of 16,709 children aged 0-3 years in Philadelphia who were primarily non-White and publicly insured. Read More

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http://dx.doi.org/10.1016/j.acap.2020.05.014DOI Listing

Host distribution and pathogen infection of fleas (Siphonaptera) recovered from small mammals in Pennsylvania.

J Vector Ecol 2020 Jun;45(1):32-44

Department of Entomology, Pennsylvania State University, University Park, PA, 16802, U.S.A.

The number of recognized flea-borne pathogens has increased over the past decade. However, the true number of infections related to all flea-borne pathogens remains unknown. To better understand the enzootic cycle of flea-borne pathogens, fleas were sampled from small mammals trapped in central Pennsylvania. Read More

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http://dx.doi.org/10.1111/jvec.12371DOI Listing

Deimplementation of the Choosing Wisely Recommendations for Low-Value Breast Cancer Surgery: A Systematic Review.

JAMA Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgery, University of Michigan, Ann Arbor.

Importance: Overtreatment of early-stage breast cancer results in increased morbidity and cost without improving survival. Major surgical organizations participating in the Choosing Wisely campaign identified 4 breast cancer operations as low value: (1) axillary lymph node dissection for limited nodal disease in patients receiving lumpectomy and radiation, (2) re-excision for close but negative lumpectomy margins for invasive cancer, (3) contralateral prophylactic mastectomy in patients at average risk with unilateral cancer, and (4) sentinel lymph node biopsy in women 70 years or older with hormone receptor-positive cancer.

Objective: To evaluate the extent to which these procedures have been deimplemented, determine the implications of decreased use, and recognize possible barriers and facilitators to deimplementation. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.0322DOI Listing

Exercise, brain plasticity, and depression.

CNS Neurosci Ther 2020 Jun 3. Epub 2020 Jun 3.

School of Physical Education and Health, Shanghai Lixin University of Accounting and Finance, Shanghai, China.

Depression is a common mental disorder characterized by high incidence, high disability, and high fatality, causing great burden to the society, families, and individuals. The changes in brain plasticity may be a main reason for depression. Recent studies have shown that exercise plays a positive role in depression, but systematic and comprehensive studies are lacking on brain plasticity changes in depression. Read More

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http://dx.doi.org/10.1111/cns.13385DOI Listing

Discharge Before Return to Respiratory Baseline in Children with Neurologic Impairment.

J Hosp Med 2020 May 21. Epub 2020 May 21.

Division of Hospital Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Background: Children with neurologic impairment (NI) are commonly hospitalized with acute respiratory infections (ARI). These children frequently require respiratory support at baseline and are often discharged before return to respiratory baseline.

Objective: To determine if discharge before return to respiratory baseline is associated with reutilization among children with NI hospitalized with ARI. Read More

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http://dx.doi.org/10.12788/jhm.3394DOI Listing

DAPT, a potent Notch inhibitor regresses actively growing abdominal aortic aneurysm via divergent pathways.

Clin Sci (Lond) 2020 Jun 3. Epub 2020 Jun 3.

The Ohio State University, Columbus, Ohio, United States.

Abdominal aortic aneurysm (AAA) is a localized pathological dilation of the aorta exceeding the normal diameter (~ 20 mm) by more than 50% of its original size (≥30 mm), accounting for ~ 150,000-200,000 deaths worldwide per year. We previously reported that Notch inhibition does not decrease the size of pre-established AAA at late stage of the disease. Here, we examined whether a potent pharmacologic inhibitor of Notch signaling (DAPT), regresses an actively growing AAA. Read More

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http://dx.doi.org/10.1042/CS20200456DOI Listing

Inhibitory mechanism of epicatechin gallate on tyrosinase: inhibitory interaction, conformational change and computational simulation.

Food Funct 2020 Jun 3. Epub 2020 Jun 3.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.

The inhibition mechanism of epicatechin gallate (ECG) on tyrosinase was investigated by multispectroscopic techniques combined with molecular docking and molecular dynamics simulation. The results demonstrated that ECG suppressed the activity of tyrosinase in a reversible mixed-inhibition with a half inhibitory concentration (IC50) of (1.13 ± 0. Read More

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http://dx.doi.org/10.1039/d0fo00003eDOI Listing

A melt-electrowritten filter for capture and culture of circulating colon cancer cells.

Mater Today Bio 2020 Mar 1;6:100052. Epub 2020 May 1.

Department of Engineering, Aarhus University, Aarhus, Denmark.

Metastasis is the major cause of death in cancer patients accounting for about 90% of the mortality. The detection and analysis of the hallmark of metastasis, circulating tumor cells (CTCs), have significant impact in cancer biology and clinical practice. However, the scarcity of CTCs in blood, particularly in that of colorectal cancer patients, is a serious bottleneck in the development of CTC-based precision medicine. Read More

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http://dx.doi.org/10.1016/j.mtbio.2020.100052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256632PMC

Examining the external-factors-led growth hypothesis for the South African economy.

Heliyon 2020 May 22;6(5):e04009. Epub 2020 May 22.

Nord University Business School (HHN), Post Box 1490, 8049 Bodø, Norway.

Reducing unemployment rate and achieving a sustainable economic growth underscore the Sustainable Development Goal 8. Our study investigates a new model that specifies the external-factors-led growth hypothesis for the South African economy. The independent variables include trade openness, external debt, FDI and exchange rate against GDP as the targeted variable. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256302PMC

Observation of Road Salt Aerosol Driving Inland Wintertime Atmospheric Chlorine Chemistry.

ACS Cent Sci 2020 May 13;6(5):684-694. Epub 2020 May 13.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan, United States.

Inland sources of particulate chloride for atmospheric nitryl chloride (ClNO) formation remain unknown and unquantified, hindering air quality assessments. Globally each winter, tens of millions of tons of road salt are spread on roadways for deicing. Here, we identify road salt aerosol as the primary chloride aerosol source, accounting for 80-100% of ClNO formation, at an inland urban area in the wintertime. Read More

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http://dx.doi.org/10.1021/acscentsci.9b00994DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256959PMC

Using grip strength to compute physical health-adjusted old age dependency ratios.

SSM Popul Health 2020 Aug 16;11:100579. Epub 2020 May 16.

Department of Economics, HEC, University of Lausanne, Switzerland.

The standard approach for comparing the potential challenges of population aging across countries based on conventional old-age dependency ratios (OADR) does not account for cross-population differences in health, functional capacity or disability, despite their importance for labor force participation and dependency more broadly. We investigate how OADRs observed across selected low-, middle-, and high-income countries change if population differences in physical health measured by hand-grip strength are accounted for. Specifically, we propose and calculate an adjusted measure of the OADR based on hand-grip strength, which serves as an objective indicator of muscle function and has been shown to predict future morbidity, disability and mortality. Read More

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http://dx.doi.org/10.1016/j.ssmph.2020.100579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262450PMC

Insidious postoperative Aspergillus niger graft aortitis.

IDCases 2020 16;21:e00823. Epub 2020 May 16.

Città della Salute e della Scienza di Torino, University of Turin, Department of Surgical Sciences, Division of Cardiac Surgery, Italy.

Fungal endocarditis/aortitis is an uncommon yet emerging entity accounting for 2% to 4% of all cases of infective endocarditis and continues to be associated with a poor prognosis. We present the first case of polyethylene-terephthalate (PETE) graft aortitis caused by , a rare fungal agent. Early diagnosis with frequent transoesophageal echocardiography (TEE) and a prompt surgical intervention coupled with optimal antifungal therapy are still the only option to reduce the exceedingly high mortality and morbidity. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256640PMC