81,383 results match your criteria Accounting And Finance[Journal]


A retrospective alternative for active surveillance trials for ductal carcinoma in situ of the breast.

Int J Cancer 2019 Apr 24. Epub 2019 Apr 24.

Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Ductal carcinoma in situ (DCIS) of the breast is a non-obligate precursor of invasive breast cancer, accounting for twenty percent of screen-detected breast cancers. Little is known about the natural progression of DCIS, because most patients undergo surgery upon diagnosis. Many DCIS patients are likely being over-treated, as it is believed that only around fifty percent of DCIS will progress to invasive carcinoma. Read More

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http://dx.doi.org/10.1002/ijc.32362DOI Listing
April 2019
2 Reads

New molecular approaches to Alzheimer's disease.

Clin Biochem 2019 Apr 21. Epub 2019 Apr 21.

Vita-Salute San Raffaele University, Milan, Italy; Unit of Genomics for Human Disease Diagnosis, Division of Genetics and Cell Biology, IRCCS San Raffaele Scientific Institute, Milan, Italy; IRCCS San Raffaele Hospital, Clinical Molecular Biology Laboratory, Milan, Italy. Electronic address:

Alzheimer's disease is a neurodegenerative disorder and the most common and devastating form of dementia. It affects mainly older people, accounting for 50-80% of dementia cases. The age is the main associated risk factor and based on the onset age, early-onset (EOAD) or late-onset (LOAD) forms are distinguished. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.010DOI Listing

Instability of Incompatible Bilayered Soft Tissues and the Role of Interface Conditions.

J Biomech Eng 2019 Apr 24. Epub 2019 Apr 24.

Faculty of Aerospace Engineering, Technion|Israel Institute of Technology.

Mechanical stability analysis is instructive in explaining biological processes like morphogenesis, organogenesis, and pathogenesis of soft tissues. Consideration of the layered, residually-stressed structure of tissues, requires accounting for the joint effects of interface conditions and layer incompatibility. This paper is concerned with the influence of imposed rate (incremental) interface conditions (RICs) on critical loads in soft tissues, within the context of linear bifurcation analysis. Read More

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http://dx.doi.org/10.1115/1.4043560DOI Listing

Discrete event simulation and pharmacy process re-engineering.

Authors:
Khalid Al Badi

Int J Health Care Qual Assur 2019 Mar;32(2):398-411

Department of Administration and Financial Affairs, Buraimi Hospital, Al-Buraimi, Oman.

Purpose: The purpose of this paper is to describe a case study undertaken at Al Buraimi Hospital in Oman, which used computer simulation and the Delphi approach to improve efficiency by reducing prescription dispensing waiting times.

Design/methodology/approach: This study's framework was based on a discrete event simulation (DES) to identify the as-is pharmacy process and to create a to-be (future situation) to achieve an improvement in pharmacy workflow and service quality. Owing to healthcare environment complexity, and to gain a deeper understanding about Al Buraimi Hospital pharmacy problems, a Delphi technique was also used. Read More

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http://dx.doi.org/10.1108/IJHCQA-05-2018-0105DOI Listing

Proposed change in an accounting rule in the UK could be good news for vaccinologists.

Authors:
Paul Griffiths

Rev Med Virol 2019 Apr 24:e2047. Epub 2019 Apr 24.

The Advanced Centre for Biochemical Engineering, University College London, London, UK.

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http://dx.doi.org/10.1002/rmv.2047DOI Listing

On the differences between mega- and meta-imputation and analysis exemplified on the genetics of age-related macular degeneration.

Genet Epidemiol 2019 Apr 23. Epub 2019 Apr 23.

Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.

While current genome-wide association analyses often rely on meta-analysis of study-specific summary statistics, individual participant data (IPD) from multiple studies increase options for modeling. When multistudy IPD is available, however, it is unclear whether this data is to be imputed and modeled across all participants (mega-imputation and mega-analysis) or study-specifically (meta-imputation and meta-analysis). Here, we investigated different approaches toward imputation and analysis using 52,189 subjects from 25 studies of the International Age-related Macular Degeneration (AMD) Genomics Consortium including, 16,144 AMD cases and 17,832 controls for association analysis. Read More

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http://dx.doi.org/10.1002/gepi.22204DOI Listing

Prenatal maternal personality as an early predictor of vulnerable parenting style.

Arch Womens Ment Health 2019 Apr 23. Epub 2019 Apr 23.

Institute for Social Science Research, The University of Queensland, Brisbane, Australia.

Perinatal mental health problems, particularly depression, are prevalent and have been a central focus of prevention initiatives. The greater proportion of ongoing annual perinatal mental health economic cost burdens relate to children. A key linking mechanism is mother-infant relationship quality. Read More

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http://dx.doi.org/10.1007/s00737-019-00963-7DOI Listing

Age-specific norms and validation of the German SDQ parent version based on a nationally representative sample (KiGGS).

Eur Child Adolesc Psychiatry 2019 Apr 23. Epub 2019 Apr 23.

Department of Epidemiology and Health Monitoring, Robert Koch Institute, General-Pape-Straße 62-64, 12101, Berlin, Germany.

The Strengths and Difficulties Questionnaire (SDQ) is the most widely used mental health screening instrument for children and adolescents. It is a short questionnaire including 25 items that can be answered by parents, teachers or children. There are two studies which report norms for the German SDQ parent version. Read More

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http://dx.doi.org/10.1007/s00787-019-01337-1DOI Listing

Gender-dependent impact of aging on facial proportions.

J Orofac Orthop 2019 Apr 23. Epub 2019 Apr 23.

Department of Orthodontics and Dentofacial Orthopedics, University Hospital RWTH Aachen, Aachen, Germany.

Purpose: Facial proportions in younger people have been evaluated in several studies. However, the number of older people who need orthognathic surgery is growing steadily. The aim of this study was to evaluate facial morphology in Caucasians accounting for age and gender. Read More

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http://dx.doi.org/10.1007/s00056-019-00176-8DOI Listing

Food and financial coping strategies during the monthly Supplemental Nutrition Assistance Program cycle.

SSM Popul Health 2019 Apr 28;7:100393. Epub 2019 Mar 28.

School of Social Policy and Practice, University of Pennsylvania, Philadelphia, PA, USA.

One in seven Americans participates in the Supplemental Nutrition Assistance Program (SNAP), making it the largest federally funded food assistance program. SNAP benefits are distributed once per month and both food spending and calorie consumption tend to decrease as time from benefit distribution increases. The monthly SNAP benefit cycle has serious implications for the health and financial stability of low-income families, a growing number of whom rely on SNAP as their sole source of income. Read More

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http://dx.doi.org/10.1016/j.ssmph.2019.100393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468142PMC

Deep Sylvian Meningioma without Dural Attachment - A Case Report.

NMC Case Rep J 2019 Apr 21;6(2):51-55. Epub 2019 Mar 21.

Department of Neurosurgery, Kagoshima City Hospital, Kagoshima, Kagoshima, Japan.

Deep Sylvian meningiomas are rare, accounting for 0.3-0.4% of all meningiomas, and mostly present in young adults and children. Read More

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https://www.jstage.jst.go.jp/article/nmccrj/6/2/6_cr.2018-02
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http://dx.doi.org/10.2176/nmccrj.cr.2018-0215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6476818PMC
April 2019
1 Read

Response diversity in Mediterranean coralligenous assemblages facing climate change: Insights from a multispecific thermotolerance experiment.

Ecol Evol 2019 Apr 12;9(7):4168-4180. Epub 2019 Mar 12.

Departament de Biologia Marina Institut de Ciències del Mar (CSIC) Barcelona Spain.

Climate change threatens coastal benthic communities on a global scale. However, the potential effects of ongoing warming on mesophotic temperate reefs at the community level remain poorly understood. Investigating how different members of these communities will respond to the future expected environmental conditions is, therefore, key to anticipating their future trajectories and developing specific management and conservation strategies. Read More

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http://dx.doi.org/10.1002/ece3.5045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6468064PMC

Prevalence of pain and treatment outcomes among cancer patients in a Malaysian palliative care unit.

Pharm Pract (Granada) 2019 Jan-Mar;17(1):1397. Epub 2019 Mar 18.

Palliative Care Unit, Queen Elizabeth Hospital. Kota Kinabalu, Sabah (Malaysia).

Background: Pain remains one of the most common and debilitating symptoms of advanced cancer. To date, there is a lack of studies on pain and its treatment among Malaysian palliative care patients.

Objective: This study aimed to explore the prevalence of pain and its treatment outcomes among adult cancer patients admitted to a palliative care unit in Sabah, Malaysia. Read More

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http://dx.doi.org/10.18549/PharmPract.2019.1.1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463407PMC

Evaluation of discharge prescriptions for secondary prevention in patients with acute coronary syndromes in Iraq.

Pharm Pract (Granada) 2019 Jan-Mar;17(1):1372. Epub 2019 Mar 11.

Specialist Mental Health and Prescribing Support Pharmacist Primary Care, Pharmacy and Prescribing Support Unit, NHS Greater Glasgow and Clyde, West Glasgow Ambulatory Care Hospital. Glasgow, Scotland (United Kingdom).

Background: Optimal prescribing of secondary prevention medications after acute coronary syndrome (ACS) events has been shown to reduce morbidity and mortality. However, it is unknown whether these medications are optimally prescribed at discharge from acute care in Iraq.

Objective: To evaluate whether patients with ACS received optimal secondary prevention medications: antiplatelets, statins, angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers (ACEI/ARBs), and beta-blockers at discharge from a cardiology unit, and to assess whether statins, ACEI/ARBs and beta-blockers were prescribed at target doses based on the American Heart Association/American College of Cardiology (AHA/ACC) guidelines. Read More

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http://dx.doi.org/10.18549/PharmPract.2019.1.1372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463406PMC

Adhesional small bowel obstruction related to stapling device from previous laparoscopic inguinal hernia repair.

BMJ Case Rep 2019 Apr 23;12(4). Epub 2019 Apr 23.

The Cambridge Colorectal Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Small bowel obstruction (SBO) is common surgical presenting problem, accounting for roughly 15 000 laparotomies per year in the UK. However, SBO post laparoscopic transabdominal preperitoneal (TAPP) inguinal hernia repair is uncommon with an estimated incidence of 0.2%-0. Read More

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http://dx.doi.org/10.1136/bcr-2019-229377DOI Listing

Setup strategies and uncertainties in esophageal radiotherapy based on detailed intra- and interfractional tumor motion mapping.

Radiother Oncol 2019 Apr 20;136:161-168. Epub 2019 Apr 20.

Aarhus University Hospital, Department of Oncology, Denmark.

Background And Purpose: Detailed knowledge of target motion is important for improved accuracy and decreased toxicity of esophageal cancer radiotherapy. This study uses the 3D trajectories of implanted markers during setup CBCT scans to investigate the intra- and interfractional tumor motion in esophageal cancer radiotherapy.

Material And Methods: For 21 esophageal cancer patients with implanted fiducial markers, 60-s 3D marker trajectories were estimated from the 2D marker positions in the projections of daily setup CBCT scans by a probability-based method. Read More

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http://dx.doi.org/10.1016/j.radonc.2019.04.014DOI Listing

Immunity of leaf-cutting ants and its role in host-parasitoid relationships.

J Insect Physiol 2019 Apr 20. Epub 2019 Apr 20.

School of Life Sciences, University of Sussex, Brighton, BN1 9QG, United Kingdom.

Parasites are an important selection pressure for all organisms, and host immune responses are key in shaping host-parasite interactions. Host species with strong immune defences may be expected to experience lower parasitism; on the other hand, investment in immune function is costly, so hosts that have evolved to invest more in immune defence may be expected to have been under greater selection pressure from parasites. Disentangling the coevolutionary dynamics requires comparative studies that quantify the immune responses of potential hosts of parasites in a community, but such studies are rare. Read More

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http://dx.doi.org/10.1016/j.jinsphys.2019.04.008DOI Listing

Pupillometric assessment of dysautonomia in pediatric bowel and bladder dysfunction: a pilot study.

J Pediatr Urol 2019 Mar 15. Epub 2019 Mar 15.

Children's National Health System, 111 Michigan Ave. NW, Washington, DC 20010, USA. Electronic address:

Bowel and bladder dysfunction (BBD) refers to a heterogeneous group of voiding disorders, accounting for an estimated 40% of pediatric urology visits. Symptoms of BBD include enuresis, urgency, and urinary retention, often accompanied by constipation. The aim of this pilot study was to explore whether a pupillary response can be characterized for BBD, by examining the pupillary light reflex (PLR) before and after voiding among patients with BBD. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183063
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http://dx.doi.org/10.1016/j.jpurol.2019.02.015DOI Listing
March 2019
1 Read

A 12-year study of fungal infections in Rio Grande do Sul, Southern Brazil.

Rev Iberoam Micol 2019 Apr 20. Epub 2019 Apr 20.

Programa de Pós-Graduação em Patologia da Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, RS, Brazil; Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil; Serviço de Dermatologia da Irmandade Santa Casa de Misericórdia de Porto Alegre, RS, Brazil; Ambulatório de Dermatologia Sanitária da Secretaria de Saúde do Estado do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Background: The number of fungal infections has increased in recent years in Rio Grande do Sul (RS), Brazil. Epidemiological studies are important for proper control of infections.

Aims: To evaluate the etiology of fungal infections in patients in RS, from 2003 to 2015. Read More

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http://dx.doi.org/10.1016/j.riam.2018.10.006DOI Listing

Examining the Roles of Heavy Episodic Drinking, Drinking Venues, and Sociosexuality in College Men's Sexual Aggression.

J Stud Alcohol Drugs 2019 Mar;80(2):177-185

Research Institute on Addictions, University at Buffalo, Buffalo, New York.

Objective: College men's alcohol consumption is positively associated with sexual aggression perpetration, yet men's drinking does not typically predict later sexual assault after accounting for risk factors, such as impersonal sexuality. In the present study, we tested an indirect effects model whereby college men's impersonal sex orientation and heavy episodic drinking (HED) were hypothesized to contribute to sexual aggression perpetration via more frequent attendance at drinking venues (parties, bars).

Method: Freshman males (N = 1,043) were recruited to participate in a five-semester study. Read More

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Glycaemic variation is a predictor of all-cause mortality in the Veteran Affairs Diabetes Trial.

Diab Vasc Dis Res 2019 Mar;16(2):178-185

2 Carl T. Hayden Phoenix VA Health Care System, Phoenix, AZ, USA.

Diabetes is associated with substantially increased mortality. Classic risk factors explain a portion of the excess of mortality in type 2 diabetes. The aim of this study was to examine whether visit-to-visit variation in fasting glucose and haemoglobin A1c values in the Veteran Affairs Diabetes Trial were associated with all-cause mortality in patients with type 2 diabetes in addition to other comorbidity conditions, hypoglycaemic events and adverse lifestyle behaviours. Read More

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http://dx.doi.org/10.1177/1479164119827598DOI Listing

Computational Methods for Detection of Differentially Methylated Regions Using Kernel Distance and Scan Statistics.

Genes (Basel) 2019 Apr 12;10(4). Epub 2019 Apr 12.

Department of Population Health Sciences, Augusta University, Augusta, GA 30912, USA.

Motivation: Researchers in genomics are increasingly interested in epigenetic factors such as DNA methylation because they play an important role in regulating gene expression without changes in the sequence of DNA. Abnormal DNA methylation is associated with many human diseases.

Results: We propose two different approaches to test for differentially methylated regions (DMRs) associated with complex traits, while accounting for correlations among CpG sites in the DMRs. Read More

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http://dx.doi.org/10.3390/genes10040298DOI Listing

Mass transport analysis of bicarbonate buffer: Effect of the CO-HCO hydration-dehydration kinetics in the fluid boundary layer and the apparent effective pKa controlling dissolution of acids and bases.

Mol Pharm 2019 Apr 23. Epub 2019 Apr 23.

The main buffering system influencing ionizable drug dissolution in the human intestinal fluid is bicarbonate-based; however, it is rarely used in routine pharmaceutical practice due to the volatility of dissolved CO. The typical pharmaceutical buffers used fail to capture the unique aspects of the hydration-dehydration kinetics of the bicarbonate-CO system. In particular, CO is involved in a reversible interconversion with carbonic acid (HCO), which is the actual conjugate acid of the system, as follows (CO + HO ⇌ HCO). Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.9b00187DOI Listing

Time Value of Greenhouse Gas Emissions in Life Cycle Assessment and Techno-Economic Analysis.

Environ Sci Technol 2019 Apr 23. Epub 2019 Apr 23.

Life cycle assessment is a fundamental tool used to evaluate the environmental impact of products. Standard life cycle assessment methodology ignores the impact of greenhouse gases relative to when they are emitted. In this paper we present a method for leveraging the social cost of greenhouse gases to account for the temporal impacts of emissions in life cycle assessment and techno-economics. Read More

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http://pubs.acs.org/doi/10.1021/acs.est.9b00514
Publisher Site
http://dx.doi.org/10.1021/acs.est.9b00514DOI Listing
April 2019
1 Read

Nanoparticle Concentration vs. Surface Area in the Interaction of Thiol Containing Molecules: Towards a Rational Nano-Architectural Design of Hybrid-Materials.

ACS Appl Mater Interfaces 2019 Apr 23. Epub 2019 Apr 23.

The effect of accounting for total surface in the association of thiol-containing molecules to nanosilver was assessed using isothermal titration calorimetry, along with a new open access algorithm which calculates the total surface area for samples of different polydispersity. Further, we used advanced molecular dynamic calculations to explore the underlying mechanisms for the interaction of the studied molecules in the presence of a nanosilver surface in the form of flat surfaces or as 3D pseudo-spherical nanostructures. Our data indicate that not only the total surface area available for binding but also the supramolecular arrangements of the molecules in the near proximity of the nanosilver surface strongly affects the affinity of thiol-containing molecules to nanosilver surfaces. Read More

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http://dx.doi.org/10.1021/acsami.9b03942DOI Listing

Nanowire Superinductance Fluxonium Qubit.

Phys Rev Lett 2019 Jan;122(1):010504

Department of Electrical Engineering, Princeton University, Princeton, New Jersey 08544, USA.

We characterize a fluxonium qubit consisting of a Josephson junction inductively shunted with a NbTiN nanowire superinductance. We explain the measured energy spectrum by means of a multimode theory accounting for the distributed nature of the superinductance and the effect of the circuit nonlinearity to all orders in the Josephson potential. Using multiphoton Raman spectroscopy, we address multiple fluxonium transitions, observe multilevel Autler-Townes splitting and measure an excited state lifetime of T_{1}=20  μs. Read More

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http://dx.doi.org/10.1103/PhysRevLett.122.010504DOI Listing
January 2019

Aromaticity and photophysics of tetrasila- and tetragerma-annelated tetrathienylenes as new representatives of the hetero[8]circulene family.

Phys Chem Chem Phys 2019 Apr 23. Epub 2019 Apr 23.

Division of Theoretical Chemistry and Biology, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 10691, Stockholm, Sweden. and Tomsk State University, 36 Lenin Avenue, Tomsk, Russia.

The electronic structure, absorption and emission spectra, aromaticity and photophysical behavior of the recently synthesized tetrasilatetrathia[8]circulene and tetragermatetrathia[8]circulene compounds have been studied computationally. Both compounds demonstrate a specific bifacial aromaticity, which is unusual for hetero[8]circulenes; the inner eight-membered core sustains an expected strong paratropic magnetically-induced ring current, while the outer perimeter contains saturated Si(Et)2 and Ge(Et)2 moieties which break the conjugation between the thiophene rings. The overall magnetically-induced ring current for both studied circulenes is close to zero because of the strong local diatropic currents in each thiophene ring that compensate the paratropic counterpart. Read More

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http://dx.doi.org/10.1039/c9cp01608bDOI Listing

Hepatic artery reconstruction with interposition of donor's right gastroepiploic artery graft in pediatric living donor liver transplantation for metabolic disease.

Pediatr Transplant 2019 Apr 23:e13418. Epub 2019 Apr 23.

Liver Transplantation Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: We introduce the indications, technique, results of our experience using donor's RGEA as interposition vessel to solve hepatic artery reconstruction problems in P-LDLT.

Methods: A retrospective analysis of P-LDLT for children with metabolic diseases from June 2013 to November 2018 in our center was carried out. The arterial conditions, reconstruction methods, and prognosis were analyzed. Read More

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http://dx.doi.org/10.1111/petr.13418DOI Listing

MRI Radiomic Features Are Independently Associated With Overall Survival in Soft Tissue Sarcoma.

Adv Radiat Oncol 2019 Apr-Jun;4(2):413-421. Epub 2019 Feb 23.

Department of Radiation Oncology, University of Washington, Seattle, Washington.

Purpose: Soft tissue sarcomas (STS) represent a heterogeneous group of diseases, and selection of individualized treatments remains a challenge. The goal of this study was to determine whether radiomic features extracted from magnetic resonance (MR) images are independently associated with overall survival (OS) in STS.

Methods And Materials: This study analyzed 2 independent cohorts of adult patients with stage II-III STS treated at center 1 (N = 165) and center 2 (N = 61). Read More

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http://dx.doi.org/10.1016/j.adro.2019.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6460235PMC
February 2019

Age, growth, mortality and recruitment of thin sharpbelly Günther, 1873 in three shallow lakes along the middle and lower reaches of the Yangtze River basin, China.

PeerJ 2019 12;7:e6772. Epub 2019 Apr 12.

Laboratoire Evolution & Diversité Biologique, Université Toulouse III, Toulouse, France.

Despite being the most dominant and widespread small fish species in the lakes along the middle and lower reaches of the Yangtze River basin, has been paid little attention by fisheries scientists and little is known about its population characteristics. For this reason, we estimated age, growth, mortality and recruitment of this species based on three shallow lakes, Biandantang Lake, Shengjin Lake and Kuilei Lake (BDT, SJH and KLH, respectively) in this region. A total of 13,585 (8,818 in BDT, 2,207 in SJH and 2,560 in KLH) individuals were collected during monthly sampling from July 2016 to September 2017. Read More

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http://dx.doi.org/10.7717/peerj.6772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6464026PMC

[Viral Hepatitis B: clinical, paraclinical and evolutionary features within the Hepatogastroenterology Department at the Aristide Le Dantec Hospital: about 728 cases].

Pan Afr Med J 2018 3;31:82. Epub 2018 Oct 3.

Service d'Hépato-gastro-entérologie, Hôpital Aristide Le Dantec, Dakar, Sénégal.

Viral Hepatitis B is a major public health problem in sub-Saharan Africa accounting for approximately 65 million of chronic carriers and 56.000 deaths per year. Our study aims to investigate the epidemiological paraclinical, therapeutic and evolutionary features of viral hepatitis B in patients followed up in our Department and to describe their serological profiles. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.82.14725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461970PMC
October 2018

Associations between Religiosity, Spirituality, and Happiness among Adults Living with Neurological Illness.

Geriatrics (Basel) 2018 Jun 23;3(3). Epub 2018 Jun 23.

Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA.

The study examined the associations between religiosity, spirituality, and happiness in 354 outpatients suffering from neurological disorders. After accounting for severity of cognitive decline, physical activity level, depression severity, and demographic variables (i.e. Read More

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http://dx.doi.org/10.3390/geriatrics3030035DOI Listing

[Hypersensitivity pneumonitis in children].

Rev Mal Respir 2019 Apr 19. Epub 2019 Apr 19.

Service de pneumologie, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France; UMR CNRS 6249, Chrono-environnement, université de Franche-Comté, 25000 Besançon, France. Electronic address:

Hypersensitivity pneumonitis (HP) is an interstitial lung disease caused by an immune response to a variety of antigens to which patients have been previously sensitised. It can occur at any age. In children, it is a rare disease, probably under-diagnosed, with an estimated prevalence of 4 per million. Read More

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http://dx.doi.org/10.1016/j.rmr.2018.06.010DOI Listing

The Fourth Industrial Revolution: Will it change pharmacy practice?

Res Social Adm Pharm 2019 Apr 16. Epub 2019 Apr 16.

Research & Development, Pharmakon, Danish College of Pharmacy Practice, Denmark. Electronic address:

The industrial world is at the beginning of a Fourth Industrial Revolution (4IR). This era will radically change the human use of technology, with major implications for the ways people live and work. This commentary asks: will 4IR change pharmacy practice? The first three revolutions created the pharmaceutical industry and gave pharmacists a near-monopoly over drug supply. Read More

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http://dx.doi.org/10.1016/j.sapharm.2019.04.003DOI Listing

The effect of age and comorbidities on early postoperative complications after radical cystectomy: A contemporary population-based analysis.

J Geriatr Oncol 2019 Apr 19. Epub 2019 Apr 19.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.

Background: Analyzing the relationship between perioperative outcomes and age in urothelial carcinoma of the bladder (UCB) patients treated with radical cystectomy (RC) in a continuous fashion may provide detailed information on the increased risk of complications in older patients, even after accounting for different comorbidity profiles. Given the limited data available in the literature, we tested these relationships within a large scale, population-based database.

Materials And Methods: Within the NIS database (2003-2015), we identified patients who underwent RC for UCB. Read More

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http://dx.doi.org/10.1016/j.jgo.2019.04.011DOI Listing

Efficacy of diffeomorphic surface matching and 3D geometric morphometrics for taxonomic discrimination of Early Pleistocene hominin mandibular molars.

J Hum Evol 2019 May 5;130:21-35. Epub 2019 Mar 5.

Department of Anthropology, Stony Brook University, Stony Brook, NY 11794, USA; Department of Anatomical Sciences, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address:

Morphometric assessments of the dentition have played significant roles in hypotheses relating to taxonomic diversity among extinct hominins. In this regard, emphasis has been placed on the statistical appraisal of intraspecific variation to identify morphological criteria that convey maximum discriminatory power. Three-dimensional geometric morphometric (3D GM) approaches that utilize landmarks and semi-landmarks to quantify shape variation have enjoyed increasingly popular use over the past twenty-five years in assessments of the outer enamel surface (OES) and enamel-dentine junction (EDJ) of fossil molars. Read More

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http://dx.doi.org/10.1016/j.jhevol.2019.01.009DOI Listing

Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review.

Diagn Pathol 2019 Apr 22;14(1):30. Epub 2019 Apr 22.

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada.

Background: Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

Case Presentation: A 50-year old female patient was investigated for a cause of abdominal discomfort. Read More

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http://dx.doi.org/10.1186/s13000-019-0807-3DOI Listing
April 2019
1 Read

Ligand Selectivity in the Recognition of Protoberberine Alkaloids by Hybrid-2 Human Telomeric G-Quadruplex: Binding Free Energy Calculation, Fluorescence Binding, and NMR Experiments.

Molecules 2019 Apr 21;24(8). Epub 2019 Apr 21.

Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA.

The human telomeric G-quadruplex (G4) is an attractive target for developing anticancer drugs. Natural products protoberberine alkaloids are known to bind human telomeric G4 and inhibit telomerase. Among several structurally similar protoberberine alkaloids, epiberberine (EPI) shows the greatest specificity in recognizing the human telomeric G4 over duplex DNA and other G4s. Read More

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http://dx.doi.org/10.3390/molecules24081574DOI Listing

Peripheral glucose levels and cognitive outcome after ischemic stroke-Results from the Munich Stroke Cohort.

Eur Stroke J 2016 Mar 1;1(1):51-60. Epub 2016 Mar 1.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.

Introduction: The relationship between glucose metabolism and stroke outcome is likely to be complex. We examined whether there is a linear or non-linear relationship between glucose measures in the acute phase of stroke and post-stroke cognition, and whether altered glucose metabolism at different time intervals (long- and short-term before stroke, acute phase) is associated with cognitive outcome.

Patients And Methods: In all, 664 consecutively recruited patients with acute ischemic stroke and without pre-stroke dementia were included in this prospective observational study. Read More

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http://dx.doi.org/10.1177/2396987316631674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301221PMC
March 2016
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Linking planetary boundaries and ecosystem accounting, with an illustration for the Colombian Orinoco river basin.

Reg Environ Change 2018 12;18(5):1521-1534. Epub 2018 Feb 12.

1Environmental Systems Analysis Group, Wageningen University and Research, PO Box 47, 6700 AA Wageningen, The Netherlands.

Economic development has increased pressures on natural resources during the last decades. The concept of planetary boundaries has been developed to propose limits on human activities based on earth processes and ecological thresholds. However, this concept was not developed to downscale planetary boundaries to sub-global level. Read More

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http://dx.doi.org/10.1007/s10113-018-1282-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448356PMC
February 2018

Peer effects in bedtime decisions among adolescents: a social network model with sampled data.

Econom J 2017 Oct 5;20(3):S103-S125. Epub 2017 Jan 5.

Bank of Italy, via Nazionale 91, 00184, Rome, Italy.

Using unique information on a representative sample of US teenagers, we investigate peer effects in adolescent bedtime decisions. We extend the nonlinear least-squares estimator for spatial autoregressive models to estimate network models with network fixed effects and sampled observations on the dependent variable. We show the extent to which neglecting the sampling issue yields misleading inferential results. Read More

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http://dx.doi.org/10.1111/ectj.12072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459319PMC
October 2017

Meta-Kriging: Scalable Bayesian Modeling and Inference for Massive Spatial Datasets.

Technometrics 2018 6;60(4):430-444. Epub 2018 Jun 6.

Universisty of California, Los Angeles.

Spatial process models for analyzing geostatistical data entail computations that become prohibitive as the number of spatial locations becomes large. There is a burgeoning literature on approaches for analyzing large spatial datasets. In this article, we propose a divide-and-conquer strategy within the Bayesian paradigm. Read More

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http://dx.doi.org/10.1080/00401706.2018.1437474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474670PMC

Association between child marriage and utilization of maternal health care services in India: Evidence from a nationally representative cross-sectional survey.

Midwifery 2019 Apr 18;75:66-71. Epub 2019 Apr 18.

Department of Geography, University of Gour Banga, Malda 732103, West Bengal, India.

Objective: In an effort to improve utilization of maternal health care services, age at marriage of girls has gain very little attention by the policy maker and programmer. Studies have indicated that child marriage has serious negative consequences on maternal health. Moreover, there is a paucity of research on explaining the links between child marriage and maternal health care utilization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02666138193009
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http://dx.doi.org/10.1016/j.midw.2019.04.007DOI Listing
April 2019
2 Reads

Pure bilateral lambdoid and posterior sagittal synostosis (Mercedes Benz syndrome), case report and literature review.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Division of Neurosurgery, IRCCS Istituto Giannina Gaslini Children's hospital, Genoa, Italy.

Background: Bilateral lambdoid and posterior sagittal synostosis (BLSS), is a rarely encountered multisutural craniosynostosis accounting for 0,3%-0,7% of all craniosynostoses. It has been named "Mercedes Benz Syndrome (MBS)" because of the bone ridges that resemble the Mercedes Benz logo. The typical headshape is usually described as anterior turricephaly combined with mild brachycephaly. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.04.117DOI Listing
April 2019
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Prognostic Factors and Treatment Patterns in the Management of Giant Cell Glioblastoma.

World Neurosurg 2019 Apr 19. Epub 2019 Apr 19.

Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California; Palo Alto Veterans Affairs Health Care System, Palo Alto, California. Electronic address:

Background: There is a lack of literature guiding treatment of giant cell glioblastoma (gcGBM), a rare subtype of glioblastoma (GBM). We used a national hospital-based registry to explore treatment patterns and outcomes associated with gcGBM.

Methods: Adult patients (age 18+) diagnosed with gcGBM or GBM between 2004-2014 were identified from the National Cancer Database (NCDB). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193109
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http://dx.doi.org/10.1016/j.wneu.2019.04.103DOI Listing
April 2019
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Computational model of the dual action of PTH - Application to a rat model of osteoporosis.

J Theor Biol 2019 Apr 19. Epub 2019 Apr 19.

St Vincent's Department of Surgery, The University of Melbourne, Clinical Science Building, 29 Regent Street, Fitzroy VIC 3065, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, 2 George Street, Brisbane QLD 4000, Australia.

This paper presents a pharmacokinetic/pharmacodynamic (PK/PD) model of the action of PTH(1-34) on bone modelling and remodelling, developed for quantitatively investigating the dose- and administration pattern-dependency of the bone tissue response to this drug. Firstly, a PK model of PTH(1-34) was developed, accounting for administration via subcutaneous injections. Subsequently, the PK model was coupled to a (mechanistic) bone cell population model of bone modelling and remodelling, taking into account the effects of PTH(1-34) on the differentiation of lining cells into active osteoblasts, on the apoptosis of active osteoblasts, and on proliferation of osteoblast precursors, as well as on the key regulatory pathways of bone cell activities. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.020DOI Listing

Abundance and diversity of nitrogen-removing microorganisms in the UASB-anammox reactor.

PLoS One 2019 22;14(4):e0215615. Epub 2019 Apr 22.

College of Resources and Environmental Science, Xinjiang University, Urumqi, China.

Anaerobic ammonium oxidation is considered to be the most economical and low-energy biological nitrogen removal process. So far, anammox bacteria have not yet been purified from cultures. Some nitrogen-removing microorganisms cooperate to perform the anammox process. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215615PLOS
April 2019
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Cost-effectiveness of acupuncture versus standard care for pelvic and low back pain in pregnancy: A randomized controlled trial.

PLoS One 2019 22;14(4):e0214195. Epub 2019 Apr 22.

AP-HP, Service de Gynécologie-Obstétrique- Hôpital Universitaire Pitié-Salpêtrière- Charles Foix, Paris, France.

Objective: To assess the cost-effectiveness of acupuncture for pelvic girdle and low back pain (PGLBP) during pregnancy.

Design: Pragmatic-open-label randomised controlled trial.

Setting: Five maternity hospitals. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214195PLOS

Weak electric fields promote resonance in neuronal spiking activity: Analytical results from two-compartment cell and network models.

PLoS Comput Biol 2019 Apr 22;15(4):e1006974. Epub 2019 Apr 22.

Department of Software Engineering and Theoretical Computer Science, Technische Universität Berlin, Germany.

Transcranial brain stimulation and evidence of ephaptic coupling have sparked strong interests in understanding the effects of weak electric fields on the dynamics of neuronal populations. While their influence on the subthreshold membrane voltage can be biophysically well explained using spatially extended neuron models, mechanistic analyses of neuronal spiking and network activity have remained a methodological challenge. More generally, this challenge applies to phenomena for which single-compartment (point) neuron models are oversimplified. Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006974DOI Listing

Expression estimation and eQTL mapping for HLA genes with a personalized pipeline.

PLoS Genet 2019 Apr 22;15(4):e1008091. Epub 2019 Apr 22.

Department of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, São Paulo, Brazil.

The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing selection, and variation at these loci is associated with many disease phenotypes. Variation in expression levels also influences disease susceptibility and resistance, but little information exists about the regulation and population-level patterns of expression. This results from the difficulty in mapping short reads originated from these highly polymorphic loci, and in accounting for the existence of several paralogues. Read More

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http://dx.doi.org/10.1371/journal.pgen.1008091DOI Listing
April 2019
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