2,359 results match your criteria Acanthosis Nigricans


Update on Management of Polycystic Ovarian Syndrome for Dermatologists.

Indian Dermatol Online J 2019 Mar-Apr;10(2):97-105

Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Polycystic ovarian syndrome (PCOS) is the commonest endocrine disorder in women having wide range of clinical manifestation. These women may present with reproductive, dermatological, metabolic, psychological, or neoplastic implications from adolescence to menopause. The common dermatological manifestations include hirsutism, acne, alopecia, or acanthosis nigricans. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_249_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434760PMC

Effectiveness and Safety of Metformin versus Canthex™ in Patients with Acanthosis Nigricans: A Randomized, Double-blind Controlled Trial.

Indian J Dermatol 2019 Mar-Apr;64(2):115-121

Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India.

Background: Acanthosis nigricans has been associated with conditions of insulin resistance such as obesity, polycystic ovary syndrome, and type 2 diabetes. Metformin and alpha-lipoic acid, two types of insulin-sensitizing agents, have been demonstrated to reduce insulin levels and improve insulin sensitivity. Alpha-lipoic acid is available as a fixed-dose combination with biotin, calcium pantothenate, and zinc sulfate as Canthex™. Read More

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http://dx.doi.org/10.4103/ijd.IJD_417_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440186PMC
April 2019
1 Read

Topical sirolimus therapy for epidermal nevus with features of acanthosis nigricans.

Pediatr Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Division of Pediatric Dermatology, University of Minnesota, Minneapolis, Minnesota.

We present a 4-year-old developmentally appropriate boy with short stature and widespread expanding epidermal nevus with features of acanthosis nigricans. He was found to have a mosaic mutation in FGFR3, the R248C variant. Despite several therapies, he continued to have growth, fissuring, and bleeding of the affected skin. Read More

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http://dx.doi.org/10.1111/pde.13833DOI Listing

Acne keloidalis nuchae and obstructive sleep apnea: a retrospective case series.

Clin Exp Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Oregon Health and Science University, Department of Dermatology, Portland, Oregon, United States.

Acne keloidalis nuchae (AKN) is an inflammatory skin disease characterized by scarring of hair follicles along the posterior neck and scalp. Most commonly, AKN is attributed to follicular irritation from hair clippers, helmets, and other external sources. Alternative explanations for disease development posit AKN as a cutaneous symptom of metabolic syndrome - similar to acanthosis nigricans in the setting of diabetes mellitus (DM). Read More

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http://dx.doi.org/10.1111/ced.13985DOI Listing
April 2019
1 Read

Confluent and Reticulated Papillomatosis Associated with Polycystic Ovarian Syndrome.

Cureus 2019 Jan 25;11(1):e3956. Epub 2019 Jan 25.

Dermatology, San Diego Family Dermatology, San Diego, USA.

Polycystic ovarian syndrome is an endocrine disorder diagnosed commonly in young women. Various cutaneous manifestations can include acanthosis nigricans, acne, hirsutism, and alopecia. Confluent and reticulated papillomatosis is a rare skin condition that may be associated with polycystic ovarian syndrome. Read More

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http://dx.doi.org/10.7759/cureus.3956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436673PMC
January 2019
1 Read

Acanthosis nigricans: To be or not to be afraid.

Oncol Lett 2019 May 19;17(5):4133-4138. Epub 2018 Nov 19.

Department of Cellular and Molecular Biology and Histology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Acanthosis nigricans (AN), a skin disorder with high prevalence, represents a dermatological condition with esthetic implications, but otherwise mild symptoms. For any clinician, it is in fact the tip of the iceberg, leading him/her to investigate what lies beneath the surface, since AN points to a systemic problem or disease: metabolic disorder (most frequently), endocrine syndrome, medication side effects, malignancy, and genetic factors. Sometimes, it is the first observed sign of a malignancy or of diabetes mellitus, especially in patients with chronic metabolic disorder; therefore, it is not to be taken lightly. Read More

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http://dx.doi.org/10.3892/ol.2018.9736DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444334PMC
May 2019
4 Reads

Influence of Work on Elevated Blood Pressure in Hispanic Adolescents in South Texas.

Int J Environ Res Public Health 2019 Mar 27;16(7). Epub 2019 Mar 27.

University of Oklahoma, College of Arts & Sciences, 633 Elm Avenue, Norman, OK 73019, USA.

Literature supports an association between work and cardiovascular disease in adults. The objective of this study was to examine the relationship between current work status and elevated blood pressure in Hispanic adolescents. Participants were students in Hidalgo County, located along the Texas-Mexico border. Read More

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http://dx.doi.org/10.3390/ijerph16071096DOI Listing
March 2019
1 Read

Comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans.

Pediatr Dermatol 2019 Mar 18. Epub 2019 Mar 18.

Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Srinakharinwirot University, Ongkharak, Thailand.

Background: There have been few published randomized controlled trials for the treatment of childhood acanthosis nigricans (AN) to date.

Objective: To assess the efficacy of topical 0.1% adapalene gel compared to 0. Read More

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http://dx.doi.org/10.1111/pde.13799DOI Listing

Aggressive papillary thyroid carcinoma in a child with type 2 congenital generalized lipodystrophy.

Arch Endocrinol Metab 2019 Feb;63(1):79-83

Grupo Brasileiro para Estudos de Lipodistrofias Herdadas e Adquiridas (BRAZLIPO), Hospital Universitário Walter Cantídio, Universidade Federal do Ceará (UFC), Fortaleza, CE, Brasil.

Thyroid carcinoma (TC) is rare in children, particularly in those aged < 10 years. Several studies have demonstrated a correlation between neoplasms and hyperinsulinemia and insulin resistance, which are often associated with a higher risk for and/or aggressiveness of the neoplasm. Congenital generalized lipodystrophy (CGL) with autosomal recessive inheritance is a rare disease and is characterized by the lack of adipose tissue, severe insulin resistance, and early metabolic disturbances. Read More

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http://dx.doi.org/10.20945/2359-3997000000096DOI Listing
February 2019
3 Reads

Case presentation of acanthosis nigricans diagnosed with gastric adenocarcinoma.

ANZ J Surg 2019 Mar 5. Epub 2019 Mar 5.

Department of Foregut Surgery, 1st Propaedeutic Surgical Clinic, 'Hippokration' General Hospital of Athens, National and Kapodistrian University of Athens, Athens, Greece.

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http://dx.doi.org/10.1111/ans.15052DOI Listing
March 2019
2 Reads

Polycystic Ovary Syndrome in Active Duty Service Women: A Retrospective Analysis.

Mil Med 2019 Feb 27. Epub 2019 Feb 27.

Graduate School of Nursing, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD.

Introduction: Women make up 16.3% of the Department of Defense (DoD) active duty military population. January 2016, the Secretary of the Defense opened all military positions to women, including combat positions. Read More

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http://dx.doi.org/10.1093/milmed/usz023DOI Listing
February 2019
12 Reads

Berardinelli-Seip syndrome and progressive myoclonus epilepsy.

Epileptic Disord 2019 Feb;21(1):117-121

Child Neurology and Psychiatry Unit, "Regina Montis Regalis" Hospital, Mondovì.

Berardinelli-Seip syndrome, or congenital generalized lipodystrophy type 2 (CGL2), is characterized by a lack of subcutaneous adipose tissue and precocious metabolic syndrome with insulin resistance, resulting in diabetes, dyslipidaemia, hepatic steatosis, cardiomyopathy, and acanthosis nigricans. Most reported mutations are associated with mild, non-progressive neurological impairment. We describe the clinical and EEG data of a patient with progressive myoclonus epilepsy (PME), CGL2, and progressive neurological impairment, carrying a homozygous BSCL2 nonsense mutation. Read More

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http://dx.doi.org/10.1684/epd.2019.1038DOI Listing
February 2019
4 Reads

Evaluation of Proinflammatory Cytokines in Obese vs Non-obese Patients with Metabolic Syndrome.

Indian J Endocrinol Metab 2018 Nov-Dec;22(6):751-756

Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.

Background: Obesity is one of the most common yet neglected public health problems in both the developed and developing countries. Metabolic syndrome (MS) is a multiplex of risk factor for the development of type 2 diabetes (T2D) and cardiovascular disease (CVD) and it reflects the clustering of multiple risk factors resulting from obesity and insulin resistance. Despite its predominance in obese individuals, MS does occur in non-obese individuals. Read More

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http://dx.doi.org/10.4103/ijem.IJEM_206_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330875PMC
February 2019
2 Reads

Acanthosis nigricans, hypochondroplasia, and FGFR3 mutations: Findings with five new patients, and a review of the literature.

Pediatr Dermatol 2019 Mar 14;36(2):242-246. Epub 2019 Feb 14.

Department of Dermatology, CHU Nantes, Nantes, France.

Early development of extensive acanthosis nigricans (AN) is a key feature in some patients who have hypochondroplasia (HCH) in association with FGFR3 mutations. We here report regarding five new patients with HCH who exhibited AN, and we compare their characteristics to the eight patients previously described in the literature. In these patients, the AN lesions began in childhood, and they were extensive. Read More

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http://dx.doi.org/10.1111/pde.13748DOI Listing
March 2019
1 Read

Cutaneous paraneoplastic syndromes.

Semin Diagn Pathol 2019 Jan 31. Epub 2019 Jan 31.

PRW Laboratories, Charlottesville, VA, United State.

A variety of cutaneous abnormalities can be seen in patients with malignant diseases, some of which are infectious, with others representing direct involvement of the skin by the underlying disorder. Yet another group of lesions can be regarded as associated markers of the malignant process, and, as such, are termed "paraneoplastic." This review considers the latter collection of conditions, grouping them by the generic type of malignancy that is usually linked to the paraneoplasia. Read More

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http://dx.doi.org/10.1053/j.semdp.2019.01.001DOI Listing
January 2019
15 Reads

Changes in inflammatory markers correlated with increased testosterone after laparoscopic sleeve gastrectomy in obese Chinese men with acanthosis nigricans.

J Dermatol 2019 Apr 6;46(4):338-342. Epub 2019 Feb 6.

Department of Endocrinology and Metabolism, School of Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.

Bariatric surgery is an effective method for severe obesity and its related comorbidities. This study was performed to explore the alterations of sex hormones and inflammatory markers following laparoscopic sleeve gastrectomy (LSG) among obese Chinese men with acanthosis nigricans (AN). Sixty-five obese men who underwent LSG were enrolled, comprising simple obesity without AN (OB group, n = 20) and obesity with AN (AN group, n = 45). Read More

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http://dx.doi.org/10.1111/1346-8138.14783DOI Listing

Comprehensive Evaluation of Type 2 Diabetes and Cardiovascular Disease Risk Profiles in Reproductive-Age Women with Polycystic Ovary Syndrome: A Large Canadian Cohort.

J Obstet Gynaecol Can 2019 Jan 31. Epub 2019 Jan 31.

Department of Obstetrics and Gynecology, College of Medicine, University of Saskatchewan, Saskatoon, SK. Electronic address:

Objective: This study compared the prevalence of metabolic syndrome (MetS) and characterized type 2 diabetes (DM2) and cardiovascular disease (CVD) risk profiles between Canadian women with polycystic ovary syndrome (PCOS) and healthy women recruited from the general population. Furthermore, within the PCOS cohort, the study contrasted the CVD and DM2 risk profiles of women with or without MetS.

Methods: Measures of MetS (International Diabetes Federation; National Heart, Lung, and Blood Institute; and the American Heart Association definition), DM2 (Diabetes Canada Clinical Guidelines), and CVD risk factors (Androgen Excess and Polycystic Ovary Syndrome Society statement) were evaluated for 237 women with PCOS (Androgen Excess and PCOS Society definitions) and 42 controls (aged 18-36) in a prospective observational study (Canadian Task Force classification II-2). Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.026DOI Listing
January 2019
2 Reads

Non-HPV Papillary Lesions of the Oral Mucosa: Clinical and Histopathologic Features of Reactive and Neoplastic Conditions.

Head Neck Pathol 2019 Mar 29;13(1):71-79. Epub 2019 Jan 29.

Department of Stomatology, Faculty of Dental Medicine, Université de Montréal Montreal, Centre-ville station, PO Box 6128, Montreal, QC, H3C 3J7, Canada.

Excluding human papillomavirus (HPV)-driven conditions, oral papillary lesions consist of a variety of reactive and neoplastic conditions and, on occasion, can herald internal malignancy or be part of a syndrome. The objectives of this paper are to review the clinical and histopathological features of the most commonly encountered non-HPV papillary conditions of the oral mucosa. These include normal anatomic structures (retrocuspid papillae, lingual tonsils), reactive lesions (hairy tongue, inflammatory papillary hyperplasia), neoplastic lesions (giant cell fibroma), lesions of unknown pathogenesis (verruciform xanthoma, spongiotic gingival hyperplasia) and others associated with syndromes (for instance Cowden syndrome) or representing paraneoplastic conditions (malignant acanthosis nigricans). Read More

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http://dx.doi.org/10.1007/s12105-019-01001-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405796PMC
March 2019
4 Reads

Randomised controlled trial to study the efficacy of exercise with and without metformin on women with polycystic ovary syndrome.

Eur J Obstet Gynecol Reprod Biol 2019 Mar 4;234:149-154. Epub 2019 Jan 4.

Dr. Baba Saheb Ambedkar Medical College and Hospital, New Delhi, India.

Objectives: 1. To study the efficacy of exercise in improving clinical symptoms, anthropometry, glucose tolerance and laboratory profile in women with Polycystic ovarian syndrome. 2. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.12.021DOI Listing
March 2019
4 Reads

Correction to: Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans.

Lasers Med Sci 2019 Jan 24. Epub 2019 Jan 24.

Student Hospital, Cairo, Egypt.

Unfortunately, there are two mistakes in the published article. The first mistake is found in the Results section, Clinical improvement subsection. The last sentence "There was no statistical difference between both sides (P=0. Read More

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http://dx.doi.org/10.1007/s10103-018-02714-zDOI Listing
January 2019
1 Read

Periorbital pigmentation: An alarming sign of metabolic syndrome.

J Cosmet Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Skin Diseases Center, Nashik, India.

Periorbital pigmentation is a commonly encountered condition which presents clinically as bilateral round, oval or semicircular homogenous dark brown pigmented macules in the periocular region. It may influence quality of life of an individual with its strong psychological impact. We present a case of middle-aged female patient, who had periorbital pigmentation as a manifestation of acanthosis nigricans. Read More

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http://doi.wiley.com/10.1111/jocd.12852
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http://dx.doi.org/10.1111/jocd.12852DOI Listing
January 2019
5 Reads

Effect of the Children's Healthy Living Program on Young Child Overweight, Obesity, and Acanthosis Nigricans in the US-Affiliated Pacific Region: A Randomized Clinical Trial.

JAMA Netw Open 2018 Oct 5;1(6):e183896. Epub 2018 Oct 5.

Department of Human Nutrition, Food and Animal Science, College of Tropical Agriculture and Human Resources, University of Hawaii at Manoa, Honolulu.

Importance: Pacific Islanders have among the highest rates of obesity and type 2 diabetes in the world. Targeting children is critical for primary prevention.

Objectives: To prevent young child overweight and obesity and to improve health in the US-Affiliated Pacific region via the Children's Healthy Living Program. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.3896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324447PMC
October 2018
5 Reads

Acanthosis nigricans in a Chinese girl with FGFR3 K650 T mutation: a case report and literature review.

BMC Med Genet 2019 Jan 11;20(1). Epub 2019 Jan 11.

Department of Endocrinology, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking Union Medical College Hospital, Beijing, China.

Background: Acanthosis nigricans (AN) is a clinical manifestation featured by velvety brown plaques in skin folds that occurs in some hereditary and syndromic disorders. Fibroblast growth factor receptor 3 (FGFR3) mutations have been identified as one of the genetic causes of inherited AN.

Case Presentation: A 17-year-old Chinese female had presented generalized acanthosis nigricans since she was 4 years old. Read More

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https://bmcmedgenet.biomedcentral.com/articles/10.1186/s1288
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http://dx.doi.org/10.1186/s12881-019-0748-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329052PMC
January 2019
16 Reads

Metabolic syndrome in dermatology: Treatment and Management for Dermatologists.

Dermatol Ther 2019 Mar 23;32(2):e12812. Epub 2019 Jan 23.

Department of Dermatology and Venerology, Cerrahpaşa Medical Faculty, İstanbul University-Cerrahpaşa, İstanbul, Turkey.

Metabolic syndrome, a commonly observed pathology and a global health issue, is closely related to the skin and thus dermatologists. The skin contributes to the development of metabolic syndrome and it is an end organ for it. Metabolic dysfunction is related to many skin disorders, some of which with high association and some of which with lower association. Read More

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http://doi.wiley.com/10.1111/dth.12812
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http://dx.doi.org/10.1111/dth.12812DOI Listing
March 2019
3 Reads

Naevoid acanthosis nigricans or RAVEN (rounded and velvety epidermal naevus) and mosaic FGFR3 and FGFR2 mutations.

Br J Dermatol 2019 Apr 17;180(4):955-957. Epub 2019 Jan 17.

Laboratory of Solid Tumour Biology, Department of Pathology and Oncology, Arnaud de Villeneuve Hospital and University of Montpellier, Montpellier, France.

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http://dx.doi.org/10.1111/bjd.17581DOI Listing
April 2019
1 Read

[Unusual facies and recurrent high triglycerides for more than one year in a girl].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1050-1054

Department of Pediatrics, First Affiliated Hospital of Hunan Normal University/Hunan Provincial People's Hospital, Changsha 410005, China.

A girl, aged 1 year and 9 months, was found to have hypertriglyceridemia in the neonatal period, with unusual facies and signs of dark skin all over the body, disappearance of subcutaneous adipose, acanthosis nigricans of the neck, excessive and thick hair, empty cheeks, muscle hypertrophy of the extremities, hepatomegaly, and neutrophil deficiency. Whole exome sequencing of monogenic disorder revealed a homozygote mutation in the BSCL2 gene, c.974 (exon 7)_c. Read More

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December 2018
2 Reads

The Association of Various Metabolic Parameters with Multiple Skin Tags.

J Clin Aesthet Dermatol 2018 Oct 1;11(10):40-43. Epub 2018 Oct 1.

Drs. Platsidaki, Vasalou, Gerodimou, Markantoni, Kouris, Gregoriou, Rigopoulos, and Kontochristopoulos are with the Department of Dermatology and Venereology at Andreas Sygros Skin Hospital in Athens, Greece.

Skin tags (STs) are benign skin lesions. Their definite etiology remains unknown. We aim to examine the association of obesity, diabetes mellitus, hyperlipidemia, thyroid abnormalities, acanthosis nigricans, and multiple STs in a Greek primary population. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239160PMC
October 2018
15 Reads

Gestational Diabetes Mellitus in a Tertiary Care Hospital of Kolkata, India: Prevalence, Pathogenesis and Potential Disease Biomarkers.

Exp Clin Endocrinol Diabetes 2018 Dec 3. Epub 2018 Dec 3.

Department of Life Sciences, Presidency University, Kolkata, India.

Aims: Prevalence of gestational diabetes mellitus (GDM) may vary across a country like India. Risk factors and disease-pathogenesis were also not fully elucidated. This study aimed to examine prevalence of GDM among pregnant women visiting antenatal clinic of a tertiary-care hospital of Kolkata, India; possible mechanism of disease pathogenesis and potency of associated parameters as disease biomarkers were also explored. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0794-6057
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http://dx.doi.org/10.1055/a-0794-6057DOI Listing
December 2018
25 Reads

Metabolic syndrome and cardiometabolic risk factors among indigenous Malaysians.

Public Health 2018 Nov 30. Epub 2018 Nov 30.

Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Sunway City, Selangor, Malaysia. Electronic address:

Objectives: This study was undertaken to investigate the occurrence of metabolic syndrome (MetS) and cardiovascular disease (CVD) risk in Orang Asli (OA), the indigenous people of Peninsular Malaysia. OA consist of Negrito, Proto-Malay, and Senoi groups who collectively comprise only 0.76% of the population of Peninsular Malaysia. Read More

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http://dx.doi.org/10.1016/j.puhe.2018.10.001DOI Listing
November 2018

De novo mutation in causes ichthyosis, , hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy.

J Med Genet 2019 Mar 28;56(3):164-175. Epub 2018 Nov 28.

NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Very long-chain fatty acids (VLCFAs) are essential for functioning of biological membranes. ELOVL fatty acid elongase 1 catalyses elongation of saturated and monounsaturated C22-C26-VLCFAs. We studied two patients with a dominant mutation. Read More

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http://dx.doi.org/10.1136/jmedgenet-2018-105711DOI Listing
March 2019
5 Reads

Acanthosis nigricans at sites of insulin injection in a man with diabetes.

CMAJ 2018 Nov;190(47):E1390

Division of Dermatology (Huang), Department of Medicine, University of Toronto, Toronto, Ont.; Scarborough General Hospital (Hessami-Booshehri), Scarborough, Ont.

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http://dx.doi.org/10.1503/cmaj.180705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246042PMC
November 2018

Posterior Distraction First or Fronto-Orbital Advancement First for Severe Syndromic Craniosynostosis.

J Craniofac Surg 2019 Jan;30(1):47-49

Department of Plastic and Reconstructive Surgery.

Purpose: Posterior calvarial vault expansion using distraction osteogenesis is performed for syndromic craniosynostosis as the first choice. This procedure allows far greater intracranial volume than fronto-orbital advancement (FOA). This study aimed to determine the most suitable timing of posterior distraction or FOA to sufficiently increase the intracranial volume and remodel the skull shape. Read More

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http://dx.doi.org/10.1097/SCS.0000000000004897DOI Listing
January 2019
3 Reads

Acanthosis nigricans in achondroplasia.

Am J Med Genet A 2018 Dec 31;176(12):2630-2636. Epub 2018 Oct 31.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

Acanthosis nigricans (AN) in those with achondroplasia has been reported occasionally in the literature previously. Other disorders arising from constitutive activation of FGFR3 also manifest AN at various frequencies. We assessed the prevalence of AN in a sequential series of 477 individuals with achondroplasia. Read More

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http://dx.doi.org/10.1002/ajmg.a.40506DOI Listing
December 2018
2 Reads

Comparison of cutaneous manifestations in diabetic and nondiabetic obese patients: A prospective, controlled study.

North Clin Istanb 2018 21;5(2):114-119. Epub 2018 May 21.

Department of Dermatology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.

Objective: Obesity is known to be a risk factor for many diseases including dermatological problems. Here, we aimed to determine the cutaneous manifestations in obese patients and the frequency of the accompanying dermatoses and to investigate the effect of diabetes mellitus in obese patients on cutaneous manifestations compared with the control group.

Methods: Our study included a total of 600 adults: 450 obese volunteers and 150 healthy volunteers. Read More

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http://dx.doi.org/10.14744/nci.2017.68553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191549PMC
May 2018
3 Reads

ASSOCIATION BETWEEN ACANTHOSIS NIGRICANS AND OTHER CARDIOMETABOLIC RISK FACTORS IN CHILDREN AND ADOLESCENTS WITH OVERWEIGHT AND OBESITY.

Rev Paul Pediatr 2018 Jul-Sep;36(3):301-308

Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.

Objective: To evaluate the presence or absence of acanthosis nigricans and its association with metabolic alterations in a group of obese and overweight children and adolescents.

Methods: A cross sectional study of 161 overweight children and adolescents, who were divided into two groups, according to presence or absence of acanthosis nigricans. Anthropometric measurements (body mass index, skinfolds, abdominal circumference), blood pressure, laboratory tests (fasting glycemia, insulin, lipid profile, triglycerides, uric acid, transaminases) and homeostasis model assessment index. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/1984-0462/;2018;36;3;00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202888PMC
April 2017
19 Reads

The Sign of Leser-Trelát and Malignant Acanthosis Nigricans Associated With Fallopian Tube Carcinoma.

Obstet Gynecol 2018 Nov;132(5):1116-1119

Departments of Dermatology and Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, and the Department of Dermatology, University of Texas Health Science Center at San Antonio, San Antonio, Texas.

Background: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses.

Case: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Read More

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http://Insights.ovid.com/crossref?an=00006250-900000000-9791
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http://dx.doi.org/10.1097/AOG.0000000000002920DOI Listing
November 2018
10 Reads

Symmetrical acral keratoderma revisited: proposal for a new term, 'pigmented carpotarsal hyperkeratosis'.

J Eur Acad Dermatol Venereol 2019 Feb 23;33(2):277-280. Epub 2018 Oct 23.

Department of Dermatology and Venereology, Third Military Medical University, Chongqing, China.

First reported from Taiwan mistakenly as acral acanthosis nigricans in 1991, pigmented carpotarsal hyperkeratosis or hyperkeratosis nigricans carpi et tarsi displays a peculiar distribution of velvety brown-grey hyperpigmented plaques symmetrically on the flexural side of the wrists and ankles and on the dorsal sides of the hands and feet. A marked epidermal hyperkeratosis with typically mild acanthosis and papillomatosis is observed in histology. Whitish maceration upon perspiration or water exposure, with exacerbation in summer but remission in winter, is common. Read More

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http://dx.doi.org/10.1111/jdv.15266DOI Listing
February 2019
3 Reads

Acanthosis nigricans in the knuckles: An early, accessible, straightforward, and sensitive clinical tool to predict insulin resistance.

Dermatoendocrinol 2018 21;10(1):e1471958. Epub 2018 May 21.

Endocrinology Division, Department of Medicine, Hospital Universitario "Dr. José E. González", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.

Any clinical/biochemical marker revealing obesity or diabetes before their appearance is valuable. Insulin resistance (IR) is present in both disorders many years before occurrence. Accordingly, we determined whether acanthosis nigricans (AN) in the knuckles is associated to higher insulin and homeostasis model assessment for estimated insulin resistance (HOMA-IR) index values, and assessed the influence of body-mass index (BMI) and the diagnostic performance of AN in the knuckles to detect IR. Read More

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https://www.tandfonline.com/doi/full/10.1080/19381980.2018.1
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http://dx.doi.org/10.1080/19381980.2018.1471958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166604PMC
May 2018
29 Reads

Síndrome metabólico y aterosclerosis carotídea subclínica en niños y adolescentes mexicanos con acantosis nigricans.

Gac Med Mex 2018;154(4):462-467

Secretaría de Salud, Instituto Dermatológico de Jalisco "Dr. José Barba Rubio", México.

Introducción: La acantosis nigricans es un marcador de resistencia a la insulina, la cual se asocia con alteraciones metabólicas y cardiovasculares.

Objetivo: Investigar la frecuencia de síndrome metabólico y aterosclerosis carotídea subclínica en niños y adolescentes mexicanos con acantosis nigricans y comparar los resultados entre sexos.

Método: Estudio transversal. Read More

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http://dx.doi.org/10.24875/GMM.18003699DOI Listing
January 2018
4 Reads

Idiopathic Eruptive Macular Pigmentation - Uncommon Presentation of an Uncommon Condition.

Indian J Dermatol 2018 Sep-Oct;63(5):409-411

Kingsway Clinic, Matunga, Mumbai, Maharashtra, India.

Idiopathic eruptive macular pigmentation (IEMP) is an asymptomatic condition with dark brown, nonconfluent lesions chiefly occurring in children and adolescents. The usual sites involved are face, trunk, extremities, and the lesions resolve over few months to years. We report an unusual presentation of this uncommon condition. Read More

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http://www.e-ijd.org/text.asp?2018/63/5/409/240090
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http://dx.doi.org/10.4103/ijd.IJD_12_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6124230PMC
September 2018
18 Reads

Physiolgic hypercortisolism at onset of celiac disease in a girl: A case report.

Medicine (Baltimore) 2018 Sep;97(36):e12160

Università Degli Studi di Milano, Milan, Italy.

Rationale: Celiac disease (CD) is an autoimmune disorder induced by dietary gluten in genetically predisposed subjects. Activation of the hypothalamic-pituitary-axis (HPA) can occur in patients with CD; however, this condition has never been described in overweight/obese CD children.

Patient Concerns: A 12-year-old girl with CD was admitted with mild acanthosis nigricans of the armpits, groin and neck. Read More

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http://dx.doi.org/10.1097/MD.0000000000012160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6133432PMC
September 2018
5 Reads

Familial acanthosis nigricans with the FGFR3 mutation: Differences of pigmentation between male and female patients.

J Dermatol 2018 Nov 31;45(11):1357-1361. Epub 2018 Aug 31.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Familial acanthosis nigricans caused by the mutation of the fibroblast growth factor receptor 3 (FGFR3) gene is characterized by short stature, hypochondroplasia and acanthosis nigricans. We herein report a Japanese family that showed a missense mutation of c.1948A>C (p. Read More

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http://dx.doi.org/10.1111/1346-8138.14623DOI Listing
November 2018
13 Reads

Current treatment options for acanthosis nigricans.

Clin Cosmet Investig Dermatol 2018 7;11:407-413. Epub 2018 Aug 7.

Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Winston-Salem, NC,

Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. While the goal of therapy is to treat the primary cause, cosmetic resolution of AN lesions can be important for patients and their quality of life. Read More

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https://www.dovepress.com/current-treatment-options-for-acan
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http://dx.doi.org/10.2147/CCID.S137527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086114PMC
August 2018
21 Reads

Mosaic mutations in FGFR3 and FGFR2 are associated with naevoid acanthosis nigricans or RAVEN (round and velvety epidermal naevus).

Br J Dermatol 2019 Jan 22;180(1):201-202. Epub 2018 Oct 22.

Department of Dermatology and Pediatric Dermatology, National Reference Centre for Rare Disorders, Centre Hospitalier Universitaire du Bordeaux, Place Amélie Raba-Léon, F-33076, Bordeaux CEDEX, France.

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http://dx.doi.org/10.1111/bjd.17095DOI Listing
January 2019

Malignant Acanthosis nigricans associated with early diagnosis of liver cancer.

An Bras Dermatol 2018 Jul-Aug;93(4):616-617

Discipline of Dermatology, Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto (SP), Brazil.

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http://dx.doi.org/10.1590/abd1806-4841.20187560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063124PMC
August 2018
7 Reads

Correction to: Comparative study using fractional carbon dioxide laser versus glycolic acid peel in treatment of pseudo-acanthosis nigricans.

Lasers Med Sci 2018 11;33(8):1839

Student Hospital, Cairo, Egypt.

The author found small mistakes in scientific content of article. Editor-in-Chief confirmed that mistakes do not change or invalidate conclusions of article. Read More

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http://dx.doi.org/10.1007/s10103-018-2596-4DOI Listing
November 2018

A Study of Clinicopathological Correlation of Periorbital Hyperpigmentation.

Indian Dermatol Online J 2018 Jul-Aug;9(4):245-249

Department of Dermatology, T. N. M. C. and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.

Context: "Dark circles" are esthetic concerns that can affect individuals of any age, gender, or race. They can be familial, physiological, or associated with various medical illnesses.

Aim: To study the clinicopathological correlation of periorbital hyperpigmentation. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_244_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042186PMC
July 2018
1 Read

Hidradenitis suppurativa in a patient with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome).

Dermatol Reports 2018 Apr 25;10(1):7546. Epub 2018 Jun 25.

Private Clinic for Dermatology, Allergy and Aesthetic Medicine, Coesfeld, Germany.

The author reports a rare presentation of hidradenitis supprutiva (HS) in combination with hyperandrogenism, insulin-resistance and acanthosis nigricans (HAIR-AN syndrome) in a female patient. Recently many clues have improved the understanding of HS as a systemic disease rather as a disease only with dermatological manifestation. This report might give another hint emphasizing the endocrinological and hormonal role in HS. Read More

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http://dx.doi.org/10.4081/dr.2018.7546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026813PMC
April 2018
1 Read

Atypical Skin Manifestations in -Related Craniosynostosis Syndromes Broaden the Phenotypic Spectrum.

Mol Syndromol 2018 May 24;9(3):149-153. Epub 2018 Apr 24.

Paediatric and Reproductive Genetics Unit, South Australian Clinical Genetics Service, Women's and Children's Hospital/SA Pathology, SA, Australia.

Crouzon syndrome (CS) and Beare-Stevenson syndrome (BSS) are craniosynostosis syndromes caused by mutations in the fibroblast growth factor 2 () gene. CS is more common (1 in 60,000 live births) than BSS, where fewer than 20 individuals have been reported. The cardinal features of BSS are craniosynostosis, cutis gyrata, acanthosis nigricans, skin furrows, skin tags, anogenital anomalies, and a prominent umbilical stump. Read More

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http://dx.doi.org/10.1159/000488439DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006653PMC
May 2018
6 Reads

Comparing the frequency of polycystic ovary syndrome in women with and without epilepsy.

J Family Med Prim Care 2018 Jan-Feb;7(1):16-20

Department of Neurology, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders; the impact of epilepsy and antiepileptic drugs influences the function of hypothalamic-pituitary-gonadal axis and dysfunction of the endocrine system and reproductive hormones in women with epilepsy. This study was carried out with an aim of determining and comparing the frequency and intensity of the complications of the hirsutism in women with and without epilepsy in Tehran in 2016-2017.

Materials And Methods: This is a cross-sectional-comparative study which was carried out on 338 women of 18-35-year-old women with and without epilepsy who were selected by continuous sampling method. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_115_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958560PMC
June 2018
34 Reads