2,438 results match your criteria Acanthosis Nigricans


Acanthosis nigricans monstre successfully treated with topical tacalcitol, metformin, and oral contraceptives.

Dermatol Ther 2020 May 23:e13660. Epub 2020 May 23.

Dermatology Unit and Skin Bank, Department of Medical, Surgical and Neuro-Sciences, University of Siena, Italy.

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http://dx.doi.org/10.1111/dth.13660DOI Listing

A novel heterozygous mutation in the insulin receptor gene presenting with type A severe insulin resistance syndrome.

J Pediatr Endocrinol Metab 2020 May 22. Epub 2020 May 22.

King's College Hospital NHS Foundation Trust, London, UK.

Background Inherited severe insulin resistance syndromes (SIRS) are rare and can be caused by mutations in the insulin receptor gene (INSR). Case presentation A 12-year-old Jamaican girl with a BMI of 24.4 kg/m2 presented with polyuria and polydipsia. Read More

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http://dx.doi.org/10.1515/jpem-2019-0503DOI Listing

A case of acanthosis nigricans in a HIV-infected patient.

BMC Infect Dis 2020 May 20;20(1):360. Epub 2020 May 20.

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.

Background: To date, very little information is available concerning the relationship between acanthosis nigricans (AN) and infection with human immunodeficiency virus type 1 (HIV-1).

Case Presentation: Herein, we report the case of a middle-aged man admitted for fever and progressively worsening dyspnea in the context of an opportunistic pneumonia and firstly diagnosed with acquired immunodeficiency syndrome (AIDS). At the time of diagnosis, physical examination revealed the presence of a palpable, hyperpigmented skin lesion on the left areola with surface desquamation and velvety texture consistent with AN. Read More

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http://dx.doi.org/10.1186/s12879-020-05089-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238735PMC

A Rare frameshift mutation in the AGPAT2 gene in a family from gaza with congenital generalized lipodystrophy.

Clin Endocrinol (Oxf) 2020 May 15. Epub 2020 May 15.

Center for prevention and treatment of atherosclerosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel.

Herein, we report a phenotypic and genetic evaluation of a consanguineous family with Congenital generalized lipodystrophy (CGL). Lipodystrophies are acquired or inherited disorders characterized by loss of adipose tissue, with distribution that is either generalized or partial. CGL is characterized by nearly complete absence of adipose tissue from birth. Read More

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http://dx.doi.org/10.1111/cen.14223DOI Listing

Maturational Hyperpigmentation: Cutaneous Marker of Metabolic Syndrome.

Dermatol Pract Concept 2020 20;10(2):e2020046. Epub 2020 Apr 20.

Cosmasure Skin Hair, Fat Management and Laser Clinic, Jabalpur, India.

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http://dx.doi.org/10.5826/dpc.1002a46DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190466PMC

Genotype-phenotype correlations of Berardinelli-Seip congenital lipodystrophy and novel candidate genes prediction.

Orphanet J Rare Dis 2020 Apr 29;15(1):108. Epub 2020 Apr 29.

Center for Bioinformatics and Computational Biology, and the Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

Background: Berardinelli-Seip congenital lipodystrophy (BSCL) is a heterogeneous autosomal recessive disorder characterized by an almost total lack of adipose tissue in the body. Mutations in the AGPAT2, BSCL2, CAV1 and PTRF genes define I-IV subtype of BSLC respectively and clinical data indicate that new causative genes remain to be discovered. Here, we retrieved 341 cases from 60 BSCL-related studies worldwide and aimed to explore genotype-phenotype correlations based on mutations of AGPAT2 and BSCL2 genes from 251 cases. Read More

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http://dx.doi.org/10.1186/s13023-020-01383-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191718PMC

Ovarian Stromal Hyperplasia: A Rare Cause of Postmenopausal Hyperandrogenism.

J Menopausal Med 2020 Apr;26(1):39-43

Department of Obstetrics and Gynecology, Manises Hospital, Valencia, Spain.

Ovarian hyperthecosis and ovarian stromal hyperplasia (OSH) are two uncommon non-neoplastic causes of ovarian hyperandrogenism, whose etiology is still unknown. These conditions are characterized by obesity, hyperinsulinemia, acanthosis nigricans, and even virilization, mainly in postmenopausal women. Here we have reported the case of a 67-year-old patient with a diagnosis of OSH, which was resolved after bilateral laparoscopic oophorectomy. Read More

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http://dx.doi.org/10.6118/jmm.19012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7160587PMC

Metabolic Syndrome and Insulin Resistance in Schoolchildren From a Developing Country.

Front Nutr 2020 31;7:31. Epub 2020 Mar 31.

Department of Pediatrics and Biochemistry, AIIMS, Bhubaneswar, India.

Overweight and obesity are prevalent in schoolchildren due to dietary habits and lack of exercise. These children are prone to metabolic syndrome (MS) and future risk of type 2 diabetes mellitus and cardiovascular diseases. This cross-sectional study was conducted in Bhubaneswar City, Eastern India, among schoolchildren. Read More

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http://dx.doi.org/10.3389/fnut.2020.00031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141174PMC

Hyperandrogenism, insulin resistance and acanthosis nigricans (HAIR-AN syndrome): an extreme subphenotype of polycystic ovary syndrome.

BMJ Case Rep 2020 Apr 9;13(4). Epub 2020 Apr 9.

Paediatric and Adolescent Gynaecology, Department of Paediatric Surgery, Queensland Children's Hospital, South Brisbane, Queensland, Australia.

HAIR-AN-a syndrome of hyperandrogenism (HA), insulin resistance (IR) and acanthosis nigricans (AN)-is a specific subphenotype of polycystic ovary syndrome (PCOS), and it is seen in almost 5% of all women with hyperandrogenism. An adolescent girl aged 11 years old was referred with adrenarche, hyperandrogenism and obesity commencing at age 8. Clinical and biochemical investigations confirmed significant hyperandrogenism and insulin resistance, and a diagnosis of HAIR-AN syndrome was made after exclusion of other differential diagnoses. Read More

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http://dx.doi.org/10.1136/bcr-2019-231749DOI Listing

- associated microcephaly and chorioretinopathy.

Ophthalmic Genet 2020 Apr 9;41(2):189-193. Epub 2020 Apr 9.

Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Microcephaly and chorioretinopathy (MCCRP) is a rare neuro-ophthalmologic disorder that causes microcephaly and chorioretinopathy. In a recessive inheritance pattern, there are three types: MCCRP1; MCCRP2 and MCCRP3. MCCRP3 results from pathogenic variants in the ( gene. Read More

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http://dx.doi.org/10.1080/13816810.2020.1747084DOI Listing

Localized acanthosis nigricans at the site of repetitive insulin injections.

Cutis 2020 Feb;105(2):E20-E22

Department of Dermatology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.

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February 2020

Association of Acanthosis Nigricans and Acrochordon with Insulin Resistance: A Cross-Sectional Hospital-Based Study from North India.

Indian J Dermatol 2020 Mar-Apr;65(2):112-117

Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Background: Insulin resistance (IR) is a pre-diabetic condition and has been reported in patients with acanthosis nigricans (AN) and acrochordon. AN and acrochordon are claimed to be cutaneous markers of IR.

Aim: The purpose of this paper was to study the association of AN and acrochordon with IR. Read More

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http://dx.doi.org/10.4103/ijd.IJD_646_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059470PMC

Intrahepatic Cholangiocarcinoma Associated with High Procalcitonin, Hypercalcemia, Polycythemia and Leukocytosis.

Cureus 2020 Jan 7;12(1):e6587. Epub 2020 Jan 7.

Gastroenterology, University of Tennessee Health Science Center, Memphis, USA.

Intrahepatic cholangiocarcinomas or bile duct cancers comprise approximately 10-20% of all cholangiocarcinomas and may present with right upper quadrant pain, weight loss, liver enzyme abnormalities or they may be completely asymptomatic and be picked incidentally on routine abdominal imaging. Typically, hepatocellular carcinomas have been associated with various paraneoplastic syndromes such as hypercalcemia, erythrocytosis, hypoglycemia, diarrhea and skin changes though paraneoplastic syndromes in the setting of cholangiocarcinoma do occur as well. Cholangiocarcinomas are usually associated with dermal paraneoplastic syndromes (Sweet syndrome, porphyria cutanea tarda, acanthosis nigricans, necrotic migratory erythema, erythema multiforme, bullous pemphigoid), hypercalcemia, leukocytosis and limbic encephalitis. Read More

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http://dx.doi.org/10.7759/cureus.6587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001129PMC
January 2020

In depth analysis of the association of FTO SNP (rs9939609) with the expression of classical phenotype of PCOS: a Sri Lankan study.

BMC Med Genet 2020 02 12;21(1):30. Epub 2020 Feb 12.

Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, PO Box 271, Kynsey Road, Colombo, 08, Sri Lanka.

Background: PCOS is a common disorder of women due to genetic, endocrine and environmental effects that manifests from puberty. The rs9939609 variant of fat mass and obesity associated (FTO) gene is linked to metabolic derangement in PCOS. We previously identified FTO (rs9939609) as a susceptibility locus for PCOS among Sri Lankan women and also explored the role of kisspeptin. Read More

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http://dx.doi.org/10.1186/s12881-020-0961-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017608PMC
February 2020

Periumbilical Acanthosis Nigricans along the Surgical Site of Umbilical Hernia Operation.

Indian J Dermatol 2020 Jan-Feb;65(1):70-72

Department of Pathology, Manisa Celal Bayar University, Faculty of Medicine, Turkey E-mail:

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http://dx.doi.org/10.4103/ijd.IJD_127_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986126PMC
February 2020

Endoscopic acanthosis nigricans appearance: A novel specific marker for diagnosis of low-grade intraepithelial neoplasia.

J Gastroenterol Hepatol 2020 Feb 4. Epub 2020 Feb 4.

Department of Gastroenterology, Shanghai General Hospital, Nanjing Medical University, Shanghai, China.

Background And Aim: At present, there is no recognized diagnostic criteria for gastric low-grade intraepithelial neoplasia (LGIN). The purpose of this study was to determine whether an "endoscopic acanthosis nigricans appearance (EANA)" could be a useful endoscopic marker for distinguishing LGIN lesions from peripheral non-neoplastic tissues.

Methods: A retrospective study was conducted on 638 cases of suspected superficial lesions with endoscopic images from white light endoscopy and magnifying endoscopy combined with narrow band imaging. Read More

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http://dx.doi.org/10.1111/jgh.15000DOI Listing
February 2020

Letter to the Editor: Comments on "Obesity associated with a novel mitochondrial tRNACys m.5802A>G mutation in a Chinese family".

Authors:
Josef Finsterer

Biosci Rep 2020 Feb;40(2)

Krankenanstalt Rudolfstiftung, Messerli Institute, Austria.

In a recent article Wang et al. reported about a 9-year-old Chinese male with obesity, insulin resistance, acanthosis nigricans, hyperuricemia, and non-alcoholic fatty liver disease (NALFD) being attributed to the variant m.5802A>G in tRNA(Cys) (Bioscience Reports (2020) 40(1), BSR20192153). Read More

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http://dx.doi.org/10.1042/BSR20194502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012652PMC
February 2020

Idiopathic extensive acanthosis nigricans with a variant of the epidermal growth factor receptor.

JAAD Case Rep 2020 Feb 16;6(2):79-82. Epub 2020 Jan 16.

Department of Dermatology, University of Alabama Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jdcr.2019.10.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965189PMC
February 2020

Comparison of the effectiveness of fractional 1550-nm erbium fiber laser and 0.05% tretinoin cream in the treatment of acanthosis nigricans: a prospective, randomized, controlled trial.

Lasers Med Sci 2020 Jan 17. Epub 2020 Jan 17.

Skin Center, Srinakharinwirot University, Bangkok, Thailand.

Acanthosis nigricans is a common dermatological problem. There are currently limited clinical trials to determine the efficacy and safety of laser treatments. To compare the efficacy of fractional 1550-nm erbium fiber laser versus 0. Read More

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http://dx.doi.org/10.1007/s10103-019-02944-9DOI Listing
January 2020

Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight/obese adolescent population.

Int J Adolesc Med Health 2020 Jan 11. Epub 2020 Jan 11.

Adolescent Clinic, Department of Pediatrics, Icahn School of Medicine at Mount Sinai/Elmhurst Hospital Center, Elmhurst, NY, USA.

Background More remains to be known about polycystic ovary syndrome (PCOS) among overweight/obese adolescents across different ethnicities especially in regards to mental illness as an associated comorbidity. Objective To determine the prevalence of PCOS among overweight and obese adolescents and to evaluate known risk factors for PCOS in a diverse population. Methods Charts of patients at an Adolescent Clinic between April 1, 2016 and July 30, 2018 were filtered using: obese, overweight and body mass index (BMI) >85%. Read More

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http://dx.doi.org/10.1515/ijamh-2019-0109DOI Listing
January 2020

Arg1201Gln mutation of insulin receptor impairs tyrosine kinase activity and causes insulin resistance: a case report.

Gynecol Endocrinol 2020 Jan 3:1-3. Epub 2020 Jan 3.

Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Type A insulin resistance syndrome (TAIRS) is a rare subtype of congenital insulin resistance (IR), which is characterized by specific clinical manifestations without clear diagnostic criteria and is easily misdiagnosed or overlooked. Herein we present a case of TAIRS with acanthosis nigricans (AN), severe IR, polycystic ovaries, hyperandrogenism and its consequence such as menstrual disturbances, acne and hirsutism. A heterozygous mutation, p. Read More

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http://dx.doi.org/10.1080/09513590.2019.1707794DOI Listing
January 2020

The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans.

J Dermatolog Treat 2020 Jan 3:1-6. Epub 2020 Jan 3.

Department of Pediatrics, Division of Pediatric Allergy and Immunology, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand.

Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans. Read More

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http://dx.doi.org/10.1080/09546634.2019.1708855DOI Listing
January 2020

A novel autosomal recessive lipodystrophy syndrome due to homozygous variant.

J Med Genet 2020 Jun 19;57(6):422-426. Epub 2019 Dec 19.

Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA

Background: Despite major advances in understanding the molecular basis of various genetic lipodystrophy syndromes, some rare patients still remain unexplained.

Cases: We report a novel autosomal recessive lipodystrophy affecting two sisters aged 17 and 19 years and characterised by early onset intellectual disability, and subsequent development of near-generalised loss of subcutaneous fat with diabetes mellitus, extreme hypertriglyceridemia, hepatic steatosis, short stature, clinodactyly, joint contractures, leiomyoma of uterus and cataracts in childhood. The lipodystrophy was more pronounced in the upper and lower extremities, and there was no associated muscular hypertrophy. Read More

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http://dx.doi.org/10.1136/jmedgenet-2019-106395DOI Listing

Predictors of Insulin Treatment During Pregnancy and Abnormal Postpartum Glucose Metabolism in Patients with Gestational Diabetes Mellitus.

Diabetes Metab Syndr Obes 2019 12;12:2655-2665. Epub 2019 Dec 12.

Department of Endocrinology, Shengjing Hospital Affiliated to China Medical University, Shenyang, Liaoning Province, People's Republic of China.

Background: To investigate the potential predictors of insulin treatment during pregnancy and abnormal postpartum glucose metabolism in gestational diabetes mellitus (GDM).

Methods: A total of 534 patients with GDM, who were diagnosed based on 75 g oral glucose tolerance test (OGTT) during pregnancy, were divided into the diet group (n=354) and insulin group (n=180) according to the treatment of hyperglycemia in pregnancy. Based on 75 g OGTT after delivery, 178 of the 534 patients were divided into the normal glucose tolerance (NGT; n=104) and the abnormal glucose tolerance (AGT; n=74) groups. Read More

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http://dx.doi.org/10.2147/DMSO.S233554DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6914658PMC
December 2019

Acanthosis Nigricans - A Two-Sided Coin: Consider Metabolic Syndrome and Malignancies!

Open Access Maced J Med Sci 2019 Sep 13;7(18):3081-3084. Epub 2019 May 13.

Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, General Skobelev 26, 1606, Sofia, Bulgaria.

Background: Acanthosis nigricans (AN) is acquired hyperpigmentation of the intertriginous body regions. Histologically, AN is characterised by a thickened stratum corneum and a variable amount of acanthosis. Although benign and rarely symptomatic, AN may be a red flag for underlying pathologies. Read More

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http://dx.doi.org/10.3889/oamjms.2019.258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6910804PMC
September 2019

Structure and function of the insulin receptor-a personal perspective.

Authors:
Masato Kasuga

Proc Jpn Acad Ser B Phys Biol Sci 2019 ;95(10):581-589

The Institute for Adult Disease, Asahi Life Foundation.

Immunoprecipitation with autoantibodies to the insulin receptor derived from patients with extreme insulin resistance and acanthosis nigricans revealed that the receptor is comprised of two subunits of 135 kDa (α subunit) and 95 kDa (β subunit) and that insulin induces the rapid phosphorylation of the β subunit in intact cells. Incubation of a highly purified insulin receptor preparation with [γ-P]ATP also resulted in tyrosine phosphorylation of the β subunit in an insulin-dependent manner, suggesting that the receptor itself is a tyrosine-specific protein kinase. Furthermore, a Japanese boy with insulin resistance and acanthosis nigricans was found to be heterozygous for a mutation of the insulin receptor gene that resulted in the replacement of glycine-996 with valine in the ATP binding site of the receptor. Read More

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http://dx.doi.org/10.2183/pjab.95.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6920081PMC
April 2020
5 Reads

Metabolic Syndrome and Skin Diseases.

Front Endocrinol (Lausanne) 2019 20;10:788. Epub 2019 Nov 20.

Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, United States.

The increasing prevalence of Metabolic syndrome (MetS) is a worldwide health problem, and the association between MetS and skin diseases has recently attracted growing attention. In this review, we summarize the associations between MetS and skin diseases, such as psoriasis, acne vulgaris, hidradenitis suppurativa, androgenetic alopecia, acanthosis nigricans, and atopic dermatitis. To discuss the potential common mechanisms underlying MetS and skin diseases, we focus on insulin signaling and insulin resistance, as well as chronic inflammation including adipokines and proinflammatory cytokines related to molecular mechanisms. Read More

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http://dx.doi.org/10.3389/fendo.2019.00788DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880611PMC
November 2019

Use of methotrexate in an exuberant case of confluent and reticulated papillomatosis of Gougerot and Carteaud in a teenager.

An Bras Dermatol 2019 Nov - Dec;94(6):717-720. Epub 2019 Oct 26.

Dermatology Service, Hospital Universitário Polyodoro Ernani de São Thiago, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.

Confluent and reticulated papillomatosis of Gougerot and Carteaud is a rare dermatosis with onset during puberty, more prevalent in females than in males. The pathogenesis is unknown, but some theories suggest either a keratinization or endocrine disorder. The lesions are verrucous, brownish, hyperkeratotic papules or spots that coalesce in a confluent and/or reticulated pattern. Read More

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http://dx.doi.org/10.1016/j.abd.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939189PMC
January 2020

Exploring the Prevalence of Undiagnosed Prediabetes, Type 2 Diabetes Mellitus, and Risk Factors in Adolescents: A Systematic Review.

J Pediatr Nurs 2020 Jan - Feb;50:94-104. Epub 2019 Nov 28.

School of Nursing and Midwifery, University of Newcastle, Australia. Electronic address:

Problem: The prevalence of prediabetes and type 2 diabetes (T2D) is increasing in adolescents worldwide. Most studies have focused on the clinical features, treatment, and complications for adolescents and so the need to generate insight into the risk factors and prevalence of undiagnosed prediabetes and T2D in adolescents across the globe remains.

Eligibility Criteria: Relevant articles that were published from 2007 up to and including January 2017 were identified through electronic searches of CINAHL, Cochrane, Medline, PsycInfo, PubMed, Scopus, Web of Science, and Sociological Abstracts (Proquest). Read More

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http://dx.doi.org/10.1016/j.pedn.2019.09.025DOI Listing
November 2019

Congenital generalized lipodystrophy: The evaluation of clinical follow-up findings in a series of five patients with type 1 and two patients with type 4.

Eur J Med Genet 2020 Apr 25;63(4):103819. Epub 2019 Nov 25.

Department of Pediatric Genetics, Istanbul University-Cerrahpaşa, Cerrahpaşa Medical Faculty, Istanbul, Turkey. Electronic address:

Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by lipoatrophy affecting the face, limbs and trunk, acromegaloid features, hepatomegaly, hypertriglyceridemia, and insulin resistance. The aim of this study is to evaluate the long-term follow-up findings including gastrointestinal and cardiac manifestations of the patients with CGL1 and CGL4, caused by mutations in the AGPAT2 and CAVIN1 genes, respectively. Two patients aged 2 and 9 years with the same biallelic CAVIN1 mutation and five patients aged between 6 months and 11 years 4 months with AGPAT2 mutations have been followed up for 3-9 years. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.103819DOI Listing

Type A insulin resistance syndrome misdiagnosed as polycystic ovary syndrome: a case report.

J Med Case Rep 2019 Nov 27;13(1):347. Epub 2019 Nov 27.

Department of Endocrinology, Hainan General Hospital, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, China.

Background: Type A insulin resistance syndrome, one type of the hereditary insulin resistance syndromes, is a rare disorder. Patients with type A insulin resistance syndrome are nonobese and demonstrate severe hyperinsulinemia, hyperandrogenism, and acanthosis nigricans. The clinical features are more severe in affected females than in males, and they mostly become apparent at the age of puberty. Read More

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http://dx.doi.org/10.1186/s13256-019-2304-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880477PMC
November 2019

Acanthosis nigricans in middle-age adults: A highly prevalent and specific clinical sign of insulin resistance.

Int J Clin Pract 2020 Mar 9;74(3):e13453. Epub 2019 Dec 9.

Research Unit, Facultad de Medicina y Hospital Universitario "Dr. Jose E. Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico.

Background: Insulin resistance (IR) precedes the diagnosis of many metabolic and non-metabolic illnesses, including type 2 diabetes mellitus (T2DM). Acanthosis nigricans (AN) is a clinical sign associated with IR. However, AN prevalence and diagnostic accuracy in middle-age adults before or at the time of prediabetes/diabetes diagnosis remain uncertain. Read More

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http://dx.doi.org/10.1111/ijcp.13453DOI Listing

Systemic sclerosis with malignant acanthosis nigricans in a patient with gastric adenocarcinoma.

JAAD Case Rep 2019 Dec 20;5(12):1045-1047. Epub 2019 Nov 20.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6872833PMC
December 2019

Nanoparticle Albumin-Bound Paclitaxel- and/or Gemcitabine-Induced Scleroderma Accompanied by Acanthosis Nigricans-Like Skin Changes.

Case Rep Dermatol 2019 Sep-Dec;11(3):273-277. Epub 2019 Oct 2.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

We herein present the first case of nanoparticle albumin-bound paclitaxel (nab-paclitaxel)- and/or gemcitabine-induced scleroderma accompanied by acanthosis nigricans-like skin changes in a 54-year-old Japanese male. He was diagnosed with pancreatic cancer and received 17 courses of nab-paclitaxel and gemcitabine chemotherapy. Edema and skin sclerosis in his legs appeared after the first and third course, respectively. Read More

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http://dx.doi.org/10.1159/000503271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873097PMC
October 2019

Mild osteochondrodysplasia with acanthosis nigricans in a short-statured Taiwanese family due to the p.Lys650Gln mutation in FGFR3.

Pediatr Neonatol 2019 12 17;60(6):686-688. Epub 2019 Sep 17.

Division of Genetics and Metabolism, Children's Hospital of China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2019.09.008DOI Listing
December 2019

Skin disease related to metabolic syndrome in women.

Int J Womens Dermatol 2019 Sep 4;5(4):205-212. Epub 2019 Jul 4.

Department of Dermatology, Alpert Medical School of Brown University, Providence, Rhode Island.

Sex hormones are involved in pathways of metabolic syndrome (MetS), an observation supported by animal studies. The relationships of sex hormones with components of MetS, such as insulin resistance and dyslipidemia, have been studied in pre- and postmenopausal women. High testosterone, low sex hormone-binding globulin, and low estrogen levels increase the risks of MetS and type 2 diabetes in women. Read More

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http://dx.doi.org/10.1016/j.ijwd.2019.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6831757PMC
September 2019

Postoperative expression of Cushing disease in a young male: metamorphosis of silent corticotroph adenoma?

Endocrinol Diabetes Metab Case Rep 2019 Oct 1;2019. Epub 2019 Oct 1.

Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh.

Summary: Silent corticotroph adenoma (SCA) is an unusual type of nonfunctioning pituitary adenoma (NFA) that is silent both clinically and biochemically and can only be recognized by positive immunostaining for ACTH. Under rare circumstances, it can transform into hormonally active disease presenting with severe Cushing syndrome. It might often produce diagnostic dilemma with difficult management issue if not thoroughly investigated and subtyped accordingly following surgery. Read More

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http://dx.doi.org/10.1530/EDM-19-0046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790907PMC
October 2019

Acanthosis Nigricans and Metabolic Risk Factors in Obese Children.

Indian J Pediatr 2020 02 16;87(2):162. Epub 2019 Oct 16.

Department of PSM, Indira Gandhi Medical College and Research Institute (IGMC&RI), Puducherry, India.

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http://dx.doi.org/10.1007/s12098-019-03080-6DOI Listing
February 2020
0.919 Impact Factor

Exogenous Insulin-Induced Localized Acanthosis Nigricans: A Rare Injection Site Complication.

Can J Diabetes 2020 Apr 23;44(3):219-221. Epub 2019 Aug 23.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:

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http://dx.doi.org/10.1016/j.jcjd.2019.08.010DOI Listing

All about skin manifestations of insulin resistance and type 2 diabetes: acanthosis nigricans and acrochordons.

Postgrad Med J 2020 Apr 13;96(1134):237. Epub 2019 Oct 13.

Endocrinology and Diabetes, St. Joseph - St. Luc Hospital, Lyon, France.

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http://dx.doi.org/10.1136/postgradmedj-2019-136834DOI Listing
April 2020
1 Read

Skin changes in the obese patient.

J Am Acad Dermatol 2019 Nov;81(5):1037-1057

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; Veterans Affairs Miami Health Care System, Miami, Florida. Electronic address:

Obesity is a worldwide major public health problem with an alarmingly increasing prevalence over the past 2 decades. The consequences of obesity in the skin are underestimated. In this paper, we review the effect of obesity on the skin, including how increased body mass index affects skin physiology, skin barrier, collagen structure, and wound healing. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.12.070DOI Listing
November 2019
1 Read

Prolonged acidosis is a feature of SGLT2i-induced euglycaemic diabetic ketoacidosis.

Endocrinol Diabetes Metab Case Rep 2019 Sep 27;2019. Epub 2019 Sep 27.

Galway University Hospitals, Galway, Ireland.

Summary: We describe two cases of SGLT2i-induced euglycaemic diabetic ketoacidosis, which took longer than we anticipated to treat despite initiation of our DKA protocol. Both patients had an unequivocal diagnosis of type 2 diabetes, had poor glycaemic control with a history of metformin intolerance and presented with relatively vague symptoms post-operatively. Neither patient had stopped their SGLT2i pre-operatively, but ought to have by current treatment guidelines. Read More

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http://dx.doi.org/10.1530/EDM-19-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6765316PMC
September 2019
5 Reads

Acanthosis Nigricans in the Knuckles of Infants: A Novel Clinical Marker of High Metabolic Risk.

Diabetes Ther 2019 Dec 10;10(6):2169-2181. Epub 2019 Oct 10.

Endocrinology Division, Facultad de Medicina y Hospital Universitario "Dr. Jose E. González", Universidad Autonoma de Nuevo Leon, Ave. Madero y Gonzalitos s/n, Colonia Mitras Centro, 64460, Monterrey, Nuevo León, Mexico.

Introduction: Acanthosis nigricans (AN) is an early clinical sign of insulin resistance (IR) primarily in adults. The prevalence and association of AN and IR in infants, however, remains uncertain. We aimed to describe the prevalence of AN and its association with IR in a group of Latin-American infants. Read More

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http://dx.doi.org/10.1007/s13300-019-00703-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848601PMC
December 2019
5 Reads

[Malignant acanthosis nigricans associated with cholangiocarcinoma].

Rev Med Interne 2019 Nov 26;40(11):750-753. Epub 2019 Sep 26.

Service de dermatologie, CHU d'Angers, 4, rue Larrey, 49100 Angers, France.

Introduction: Acanthosis nigricans is a dermatosis characterized by the presence of a hyperpigmented, velvety cutaneous thickening in the flexural areas, especially axillary and inguinal fossas, and lateral faces of the neck. AN is usually a benign condition but can sometimes reveal an internal malignancy corresponds to a cutaneous paraneoplasic syndrome. Literature shows a predominant association with gastric adenocarcinoma. Read More

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http://dx.doi.org/10.1016/j.revmed.2019.08.003DOI Listing
November 2019
2 Reads

Acanthosis nigricans in childhood: A cutaneous marker that should not be underestimated, especially in obese children.

Acta Paediatr 2020 Mar 14;109(3):481-487. Epub 2019 Oct 14.

Paediatric Diabetes and Metabolic Disorders Unit, University Hospital of Verona, Verona, Italy.

Aim: The occurrence of acanthosis nigricans (AN) in childhood should not be underestimated since it acts as a cutaneous marker of underlying diseases, such as insulin resistance, endocrinopathy, syndromes and malignancy. The purpose of this review was to highlight the clinical significance of AN in childhood and draw attention to its possible role as early marker of alterations in glucose metabolism in obese children.

Methods: The Cochrane Library and PubMed databases were searched for papers published in English up to April 2019. Read More

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http://dx.doi.org/10.1111/apa.15031DOI Listing
March 2020
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Fatty Liver and Autoimmune Hepatitis: Two Forms of Liver Involvement in Lipodystrophies.

GE Port J Gastroenterol 2019 Aug 30;26(5):362-369. Epub 2019 Jan 30.

Gastroenterology Unit, Pediatrics Division, Child and Adolescent Department, Centro Materno Infantil do Norte, Centro Hospitalar Universitário do Porto, Porto, Portugal.

Introduction: Lipodystrophies are a heterogeneous group of rare diseases (genetic or acquired) characterized by a partial or generalized deficit of adipose tissue, resulting in less energy storage capacity. They are associated with severe endocrine-metabolic complications with significant morbidity and mortality. In the pathogenesis of the acquired forms, immunological disorders may be involved. Read More

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http://dx.doi.org/10.1159/000495767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751459PMC
August 2019
3 Reads

Cardiometabolic Risk Profile Among Young Adult Females With a History of Premature Adrenarche.

J Endocr Soc 2019 Oct 15;3(10):1771-1783. Epub 2019 Jul 15.

Department of Pediatrics, University of Eastern Finland, Kuopio, Finland.

Context: Premature adrenarche (PA) is associated with childhood overweight and hyperinsulinemia; the long-term cardiometabolic outcome is unknown.

Objective: To study cardiometabolic profile in adult women with previous PA.

Design And Participants: Thirty women with PA and 41 control subjects were followed from prepuberty to young adulthood. Read More

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http://dx.doi.org/10.1210/js.2019-00193DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6733041PMC
October 2019

Systemic and Autoimmune Diseases.

Clin Colon Rectal Surg 2019 Sep 6;32(5):372-376. Epub 2019 Sep 6.

Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.

This article reviews the clinical features of systemic and autoimmune diseases affecting the perianal region and its surrounding integumentary structures. Read More

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http://dx.doi.org/10.1055/s-0039-1687833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731114PMC
September 2019
1 Read

Endocrinology of Hirsutism: From Androgens to Androgen Excess Disorders.

Front Horm Res 2019 9;53:108-119. Epub 2019 Sep 9.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Hacettepe University School of Medicine, Ankara, Turkey,

Unwanted sexual hair growth has a considerable negative impact on a woman's self-esteem and quality of life. Excessive growth of terminal hair in women in a man-like pattern is defined as hirsutism and affects up to 1 in 7 women. Androgens secreted by the ovary and adrenal are the main regulator of physiological and pathological alterations of skin hair. Read More

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http://dx.doi.org/10.1159/000494907DOI Listing
March 2020
2 Reads

The metabolic salute: A unique presentation of transverse nasal acanthosis nigricans and allergic rhinitis in an obese pediatric patient.

Pediatr Dermatol 2019 Nov 9;36(6):973-974. Epub 2019 Sep 9.

Verum Cutis Dermatology, Ashburn, VA, USA.

Acanthosis nigricans (AN) is a well-known cutaneous condition that is most commonly associated with insulin resistance and obesity when present in a pediatric patient. We present a unique presentation of AN in an adolescent African American girl with a history of perennial allergic rhinitis. She presented with AN affecting the neck, axillae, as well as the transverse nasal crease, a consequence of habitual pushing of the nasal tip upward due to chronic obstruction and itching from allergic rhinitis known as the "allergic salute. Read More

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http://dx.doi.org/10.1111/pde.13989DOI Listing
November 2019
1 Read