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Evid Based Complement Alternat Med 2022 13;2022:2635375. Epub 2022 May 13.

Department of Gynecology of Traditional Chinese Medicine, Changhai Hospital, Naval Medical University, Shanghai 200433, China.

Objective: Bushen Huoxue Huatan Decoction (BHHD) is a classic prescription for treating polycystic ovary syndrome (PCOS). This study aims to explore the effects and possible mechanisms of BHHD on PCOS by integrating network pharmacology and clinical study.

Methods: The components and potential drug targets of BHHD were analysed using the TCMSP platform, and the potential pathogenesis targets for PCOS were analysed using the GeneCards and OMIM databases. Read More

Int Med Case Rep J 2022 12;15:245-250. Epub 2022 May 12.

Department of Pediatric Endocrinology, Sidra Medicine, Doha, Qatar.

Type 2 diabetes is a chronic disease due to insulin resistance resulting in hyperglycemia. The prevalence of type 2 diabetes is increasing worldwide in the pediatric population. In the pediatric population, type 2 diabetes typically develops around adolescence; however, patients with a younger age of onset are now being reported. Read More

Aten Primaria 2022 May 12;54(6):102354. Epub 2022 May 12.

Health Research Group GIIS100 of Health Research Institute IIS Aragón, Zaragoza, España; Servicio de Dermatología y Venereología, Hospital Clínico Universitario Miguel Servet, Zaragoza, España.

Objetive: To review and discuss the current evidence of the use of metformin as a therapeutic tool in frequent skin diseases.

Design: Original article. Qualitative research. Read More

BMC Womens Health 2022 May 13;22(1):165. Epub 2022 May 13.

Department of Obstetrics and Gynecology, Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, 56219, Saudi Arabia.

Background: Polycystic ovary syndrome (PCOS) is a global health problem associated with significant morbidity during reproductive age. Only a few published studies that address the clinical manifestations and phenotypic presentation of the disease have been conducted in Africa, including Sudan. Thus, this study aimed to evaluate the clinical and biochemical presentation of the different PCOS phenotypes among infertile Sudanese women. Read More

Transl Pediatr 2022 Apr;11(4):595-600

Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Alstrom syndrome (ALMS) is an ultra-rare multisystem genetic disorder caused by autosomal recessive inheritance of the ALMS1 gene. It manifests as multisystem dysfunction, displaying unique clinical signs and symptoms and various severity, which may lead to delayed prognosis or misdiagnosis in medical practice. Although almost 300 pathogenic variants have been reported, there are some variant sites that have not been recognized yet. Read More

Pediatr Dermatol 2022 May 9. Epub 2022 May 9.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Confluent and reticulated papillomatosis (CARP) is a dermatosis that often presents during adolescence. Prior studies have linked CARP to metabolic syndrome and comorbidities associated with insulin resistance, such as acanthosis nigricans and type 2 diabetes. Despite this, few studies have evaluated the clinical relationship between glucose dysmetabolism and CARP. Read More

JAAD Case Rep 2022 Jun 3;24:78-81. Epub 2022 May 3.

Department of Dermatology, Stanford University School of Medicine, Stanford, California.

Diabetol Int 2022 Apr 11;13(2):381-386. Epub 2021 Oct 11.

Division of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.

Objectives: To describe the epidemiology, clinical, biochemical, immunological and radiological aspects of youth with type 2 diabetes.

Methods: Patients under 18 year of age with type 2 diabetes were recruited from 2018 to 2020, clinical data collected, autoantibodies (GAD65, IAA, IA2 and ZnT8), insulin, ALT and c-peptide were measured. Hepatic ultrasound was performed for assessment of non-alcoholic fatty liver disease (NAFLD). Read More

Pediatr Dermatol 2022 03;39(2):295-296

Int J Dermatol 2022 Apr 8. Epub 2022 Apr 8.

Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Dermatol Res Pract 2022 28;2022:2906189. Epub 2022 Mar 28.

Unidad de Investigación Médica en Bioquímica, Unidad Médica de Alta Especialidad "Dr. Bernardo Sepúlveda", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.

Background: Acanthosis nigricans (AN) is a clinical sign that commonly occurs in obesity; however, its specificity and sensitivity have been controversial. It is unknown if AN severity degree can be a useful marker for cardiometabolic disorders screening. We suggest that the stratified analysis of AN severity degree in neck by Burke's scale could be a useful tool in the screening of cardiometabolic alterations in obese children. Read More

Clin Exp Dermatol 2022 Apr 5. Epub 2022 Apr 5.

Department of Dermatology, Venereology, and Leprosy; KPC Medical College & Hospital, Kolkata, India.

Obese and overweight individuals may have a wide spectrum of cutaneous features and can have more severe manifestations of multiple dermatological conditions. There have been multiple expert opinions on the role of weight loss, in the improvement of skin conditions. There have been few studies over the past decade evaluating the effects of exercise and other modes of weight reduction on various dermatoses such as psoriasis, acne vulgaris, hidradenitis suppurativa and acanthosis nigricans. Read More

Front Nutr 2022 10;9:855573. Epub 2022 Mar 10.

Department of Pharmacology and Toxicology, Medical Faculty, Medical University, Sofia, Bulgaria.

Obesity as a multi-organ disease that affects the entire human organism. Notably, the skin is no exclusion from this postulate. Skin changes in obese patients have been widely studied with regards to mechanical friction, skin infections, and skin hypertrophic conditions, such as acanthosis nigricans and, most commonly, fibromas (skin tags). Read More

Ginekol Pol 2022 Mar 22. Epub 2022 Mar 22.

Gynecology Department, University Hospital Center of Coimbra (CHUC), Portugal, Portugal.

Objectives: Analysis of congenital adrenal hyperplasia (CAH) cases, gynaecological implications, referral reasons to gynaecologist and treatment.

Material And Methods: Retrospective, longitudinal, single-centre study with female CAH paediatric patients ≥ 10 years-old, followed between 1998-2018 in gynaecology and endocrinology departments at a public university tertiary hospital.

Results: 47 patients, 34. Read More

JMIR Form Res 2022 Mar 15;6(3):e29967. Epub 2022 Mar 15.

Department of Mathematics and Statistics, University of Massachusetts Amherst, Newton, MA, United States.

Background: Artificial intelligence and digital health care have substantially advanced to improve and enhance medical diagnosis and treatment during the prolonged period of the COVID-19 global pandemic. In this study, we discuss the development of prediction models for the self-diagnosis of polycystic ovary syndrome (PCOS) using machine learning techniques.

Objective: We aim to develop self-diagnostic prediction models for PCOS in potential patients and clinical providers. Read More

Indian Dermatol Online J 2022 Mar-Apr;13(2):221-228. Epub 2022 Mar 3.

Department of Community Medicine, NIMS, Jaipur, Rajasthan, India.

Background: Facial acanthosis nigricans (FAN) is an underrecognized and underdiagnosed entity. The typical presentation of acanthosis nigricans (AN) seen elsewhere on the body like axillae and groins is not seen on the face, making it mimic other pigmentary disorders. Moreover, FAN is seldom not accompanied with AN on the classical sites making the diagnosis challenging. Read More

Pediatr Dermatol 2022 Mar 14. Epub 2022 Mar 14.

Department of Dermatology, Aydın Adnan Menderes University Faculty of Medicine, Aydın, Turkey.

Background: Cutaneous changes in obese adults have been investigated in numerous studies, but this issue has not been adequately investigated in children.

Objectives: We aimed to determine the prevalence of skin manifestations in children with obesity by comparing them to normal-weight children.

Methods: A cross-sectional study was conducted between June 2017 and January 2019 in which 82 children with obesity and 86 normal-weight healthy control children were enrolled. Read More

J Exp Med 2022 04 7;219(4). Epub 2022 Mar 7.

Université de Paris, Imagine Institute, Laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, Institut National de la Santé et de la Recherche Médicale UMR1163, Paris, France.

Crouzon syndrome with acanthosis nigricans (CAN, a rare type of craniosynostosis characterized by premature suture fusion and neurological impairments) has been linked to a gain-of-function mutation (p.Ala391Glu) in fibroblast growth factor receptor 3 (FGFR3). To characterize the CAN mutation's impact on the skull and on brain functions, we developed the first mouse model (Fgfr3A385E/+) of this syndrome. Read More

Eur J Endocrinol 2022 Mar 23;186(5):543-552. Epub 2022 Mar 23.

Division of Paediatric Endocrinology, Department of Paediatrics, Willem-Alexander Children's Hospital, Leiden University Medical Center, Leiden, Netherlands.

Objective: To describe clinical, laboratory, and genetic characteristics of three unrelated cases from Chile, Portugal, and Saudi Arabia with severe insulin resistance, SOFT syndrome, and biallelic pathogenic POC1A variants.

Design: Observational study.

Methods: Probands' phenotypes, including short stature, dysmorphism, and insulin resistance, were compared with previous reports. Read More

Dermatol Pract Concept 2022 Feb 1;12(1):e2022009. Epub 2022 Jan 1.

Dermatology Unit, Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain.

Pediatr Diabetes 2022 Jun 10;23(4):447-456. Epub 2022 Mar 10.

Department of Pediatrics, Division of Diabetes and Endocrinology, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.

Introduction: Maturity-onset diabetes of the young (MODY) is often misdiagnosed as type 1/type 2 diabetes. We aimed to define patient characteristics to guide the decision to test for MODY in youth with diabetes.

Research Design And Methods: Of 4750 patients enrolled in the Diabetes Registry at Texas Children's Hospital between July 2016 and July 2019, we selected ("Study Cohort", n = 350) those with: (1) diabetes diagnosis <25 years, (2) family history of diabetes in three consecutive generations, and (3) absent islet autoantibodies except for GAD65. Read More

Orbit 2022 Feb 11. Epub 2022 Feb 11.

Department of Ophthalmology, Royal Free Hospital, London, UK report adhered to the ethical principles outlined in the Declaration of Helsinki as amended in 2013. Signed patient consent was obtained.

J Family Med Prim Care 2021 Nov 29;10(11):4218-4222. Epub 2021 Nov 29.

Department of Health Sciences Research, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Introduction: Acanthosis nigricans (AN) is a brown to black, poorly defined velvety hyperpigmentation of the skin. It is a predisposition factor for Type 2 diabetes, malignancies and various endocrinopathies. The available data regarding AN from Kerala is limited. Read More

touchREV Endocrinol 2021 Apr 28;17(1):54-58. Epub 2021 Apr 28.

Department of Endocrinology, Mymensingh Medical College, Mymensingh, Bangladesh.

The features of polycystic ovary syndrome (PCOS) vary greatly among adolescent girls and adult women. Some of the features of PCOS may overlap with features of normal pubertal development in girls. This cross-sectional study was conducted among adolescents newly diagnosed with PCOS attending a tertiary hospital in Bangladesh. Read More

Metab Syndr Relat Disord 2022 Apr 24;20(3):174-181. Epub 2022 Jan 24.

Tecnologico de Monterrey, Escuela Medicina y Ciencias de la Salud, Grupo de Enfoque en Medicina Cardiovascular y Metabolómica, Monterrey, México.

This study provides a clinical model to identify children with insulin resistance (IR) in health care units where laboratory tests are not readily available. A retrospective study of Mexican children aged 2-16 years at an obesity (OB) clinic. A receiver operating characteristic (ROC) curve was used to assess the accuracy of the proposed model consisting of clinical parameters and to establish the cutoff value for the variables (439 children). Read More

Horm Res Paediatr 2022 21;95(1):25-34. Epub 2022 Jan 21.

Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Introduction: The role of DNA methylation in metabolic dysregulation is emerging. However, the functional role of methylation in obesity and metabolic dysregulation is poorly understood.

Aim: The aim of this study was to compare DNA methyltransferase-3A (DNMT3A) and ten-eleven translocase-2 (TET2) levels in children and adolescents with obesity to normal-weighed children and adolescents and to correlate them to various metabolic parameters. Read More

JAAD Case Rep 2022 Jan 11;19:94-96. Epub 2021 Nov 11.

Centre Hospitalier Universitaire Amiens-Picardie, Amiens, France.

Nan Fang Yi Ke Da Xue Xue Bao 2021 Dec;41(12):1780-1786

Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital of Nanjing Medical University, Shanghai 200072, China.

Objective: To investigate the correlation of the total testosterone (TT) level with insulin secretion and resistance in patients with acanthosis nigricans (AN) and non-acanthosis nigricans (NAN).

Methods: This study was conducted in a total of 639 overweight patients (body mass index ≥24 kg/m), including 137 female AN patients, 277 female NAN patients, 129 male AN patients, and 146 male NAN patients. Each group was further divided into 4 subgroups according to the quartile of TT level for comparison of insulin secretion and insulin resistance parameters. Read More

Acta Dermatovenerol Croat 2021 Dec;29(3):167-168

Kozo Nakai, MD, PhD, Department of Dermatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan;

Dear Editor, Nevoid acanthosis nigricans (AN) is a rare form of benign AN that can be mostly found as a solitary lesion distributed along Blaschko's lines (1). It is not associated with any known syndrome, endocrinopathy, drugs, or internal malignancy. Treatments include retinoid, calcipotriol, and laser treatments (2). Read More

J Cosmet Dermatol 2021 Dec 31. Epub 2021 Dec 31.

Department of Skin & V.D, Nalanda Medical College and Hospital, Patna, India.

Background: Acanthosis nigricans (AN) is a common dermatosis that presents with hyperpigmented, velvety thick plaques over intertriginous areas. Though a number of treatment modalities including chemical peels have been used, none provide long-term and sustained improvement.

Aim And Objectives: Our study evaluated the efficacy and safety of regular sessions of salicylic acid-mandelic acid peeling over axillary AN lesions, which was followed by daily application of a topical combination of glycolic acid, urea, and cetylated fat esters for maintenance of effect for 9 months. Read More