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    Acanthosis nigricans: A screening test for insulin resistance - An important risk factor for diabetes mellitus type-2.
    J Family Med Prim Care 2017 Jan-Mar;6(1):43-46
    Department of Family Medicine, Aster MIMS Hospital, Kozhikode, Kerala, India.
    Background: Acanthosis nigricans (AN) is one of the signs suggestive of high insulin resistance (IR). IR is one of the mechanisms involved in pathogenesis of diabetes mellitus type-2 (DM Type-2). Thus, early detection of IR in children may allow us time to intervene well before the development of DM Type-2. Read More

    Acanthosis nigricans in a Japanese boy with hypochondroplasia due to a K650T mutation in FGFR3.
    Clin Pediatr Endocrinol 2017 28;26(4):223-228. Epub 2017 Sep 28.
    Department of Pediatrics, Ehime University Graduate School of Medicine, Ehime, Japan.
    Acanthosis nigricans (AN) is observed in some cases of skeletal dysplasia. However, AN has occasionally been reported in patients with hypochondroplasia (HCH), and a clinical diagnosis is sometimes difficult when its physical and radiological features are mild. Mutations in the gene encoding the fibroblast growth factor receptor 3 (FGFR3) have been identified as the cause of some types of skeletal dysplasia, which is diagnostically useful. Read More

    Imaging of Skeletal Disorders Caused by Fibroblast Growth Factor Receptor Gene Mutations.
    Radiographics 2017 Oct;37(6):1813-1830
    From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110 (K.M.S.); Department of Radiology, University of Texas Health Science Center San Antonio, San Antonio, Tex (A.K.S.); and Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa (S.C.K.).
    Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. FGFR1, FGFR2, and FGFR3 are crucial for both chondrogenesis and osteogenesis. Mutations in the genes encoding FGFRs, types 1-3, are responsible for various skeletal dysplasias and craniosynostosis syndromes. Read More

    Clinical profile of diabetes at diagnosis among children and adolescents at an endocrine clinic in Ghana.
    World J Diabetes 2017 Sep;8(9):429-435
    International Diabetes Federation Life for a Child Program, Glebe, NSW 2037, Australia.
    Aim: To determine the clinical features of diabetes in children and adolescents in Ghana.

    Methods: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016.

    Results: One hundred and six subjects presented with diabetes. Read More

    Differences between Metabolically Healthy vs Unhealthy Obese Children and Adolescents.
    J Natl Med Assoc 2017 Autumn;109(3):203-210. Epub 2017 Apr 6.
    Division of Pediatric Endocrinology, Department of Pediatrics, SUNY Downstate Medical Center and Kings County Hospital Center, Brooklyn, NY, USA. Electronic address:
    Obesity is on the rise worldwide. An obesity subtype, metabolically healthy obese (MHO), is resilient to unfavorable metabolic and cardiovascular effects. Factors predicting MHO phenotype are not well characterized. Read More

    Prevalence of dermatologic manifestations and metabolic biomarkers in women with polycystic ovary syndrome in north China.
    J Cosmet Dermatol 2017 Sep 21. Epub 2017 Sep 21.
    Department of Dermatology, Xuan Wu Hospital Capital Medical University, Beijing, China.
    Background: Cutaneous features of hyperandrogenism in polycystic ovary syndrome (PCOS) include acne, hirsutism, seborrhea, androgenic alopecia (AGA), and acanthosis nigricans (AN). However, the relationships have not been well known broadly in terms of clinical hyperandrogenism and biochemical markers.

    Objectives: The aim of this study was to investigate biochemical and metabolic parameters in relation to cutaneous characters women in with and without PCOS. Read More

    Terra Firma-Forme Dermatosis Misdiagnosed as Nevoid Acanthosis Nigricans.
    Am J Dermatopathol 2017 Oct;39(10):782-784
    Departments of *Dermatology, and†Pathology, Başkent University İstanbul Hospital, İstanbul, Turkey.
    Terra firma-forme dermatosis (TFFD) is a clinical condition characterized by brown-gray, velvety, pigmented patches or plaques, resembling dirt on the skin. Nevoid acanthosis nigricans (NAN) is a rare and recently described form of acanthosis nigricans occurring during childhood or early adulthood. Herein we describe a patient with TFFD, initially misdiagnosed as NAN. Read More

    Prevalence of Acanthosis nigricans and Related Factors in Iranian Obese Children.
    J Clin Diagn Res 2017 Jul 1;11(7):SC05-SC07. Epub 2017 Jul 1.
    Assistant Professor, Pediatric Intensifier, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran.
    Introduction: Recognition of Acanthosis nigricans (AN) provides important opportunities for screening of obesity syndrome, dyslipidemia, hypertension and insulin resistance with diabetes mellitus 2. Considering the high prevalence of obesity among Iranian children, we designed this study to estimate the prevalence of AN and related laboratory factors in Iranian obese children.

    Materials And Methods: Seventy-one obese children were enrolled in this study. Read More

    Glucose alteration and insulin resistance in asymptomatic obese children and adolescents.
    J Pediatr (Rio J) 2017 Aug 26. Epub 2017 Aug 26.
    Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.
    Objective: Obesity is associated with the abnormal glucose metabolism preceding type 2 diabetes mellitus. Thus, further investigation on the prediction of this lethal outcome must be sought. The objective was the profile glycemic assessment of asymptomatic obese children and adolescents from Salvador, Brazil. Read More

    Antibody-Mediated Extreme Insulin Resistance: A Report of Three Cases.
    Am J Med 2017 Aug 16. Epub 2017 Aug 16.
    Division of Endocrinology, Diabetes, & Metabolism, Department of MedicineThe Johns Hopkins University School of Medicine, Baltimore, Md. Electronic address:
    Background: Type 2 diabetes mellitus is characterized by relative insulin deficiency and insulin resistance. Features suggesting severe insulin resistance include acanthosis nigricans, hyperandrogenism, weight loss, and recurrent hospital admissions for diabetic ketoacidosis. In rare circumstances, hyperglycemia persists despite administration of massive doses of insulin. Read More

    Type 1 Diabetes and Non-Alcoholic Fatty Liver Disease: When Should We Be Concerned? A Nationwide Study in Brazil.
    Nutrients 2017 Aug 15;9(8). Epub 2017 Aug 15.
    Department of Internal Medicine, Diabetes Unit, State University of Rio de Janeiro (UERJ), Boulevard 28 de Setembro, 77-3º andar-Vila Isabel, Rio de Janeiro-RJ CEP 20551-030, Brazil.
    Obesity is increasing worldwide, affecting even patients with type 1 diabetes (T1D). A higher prevalence of associated comorbidities is expected, such as non-alcoholic fatty liver disease (NAFLD). This paper reports a cross-sectional multicenter study on a population with T1D (n = 1662), which aimed to evaluate the prevalence of metabolic syndrome (MS), a known risk factor for NAFLD, and to investigate predisposing factors associated with MS, as well as factors associated with elevated alanine aminotransferase (ALT), as it correlates to liver fat content. Read More

    Acanthosis Nigricans and Its Response to Metformin.
    Pediatr Dermatol 2017 Sep 30;34(5):e281-e282. Epub 2017 Jul 30.
    Department of Paediatric Endocrinology, Alder Hey Children's National Health Service Foundation Trust, Liverpool, UK.
    Acanthosis nigricans (AN) is the most common cutaneous manifestation of insulin resistance (IR) and is commonly seen in non-Caucasian populations. Variable benefits of metformin in the treatment of AN have been reported in the literature. We report an adolescent Caucasian boy with IR and extensive AN who showed complete resolution of AN after 2 years of metformin, despite persistence of IR. Read More

    Paediatric obesity treatment had better outcomes when children were younger, well motivated and did not have acanthosis nigricans.
    Acta Paediatr 2017 Nov 18;106(11):1842-1850. Epub 2017 Jul 18.
    Department of Paediatrics, University of Eastern Finland, Kuopio, Finland.
    Aim: This study evaluated the efficacy of a paediatric obesity treatment programme and explored the factors that contributed to the outcome.

    Methods: We recorded the body mass index standard deviation scores (BMI SDS) of 654 children aged 2-18 years who were treated for obesity in 2005-2012 in three Finnish hospitals, one year before treatment and up to three years after treatment. The family-based multidisciplinary treatment included nutritional advice, exercise and behavioural counselling. Read More

    A Mutation in INSR in a Child Presenting with Severe Acanthosis Nigricans.
    J Clin Res Pediatr Endocrinol 2017 Jun 30. Epub 2017 Jun 30.
    Rabson Mendenhall Syndrome (RMS) is an autosomal recessive disorder due to the mutations in insulin receptor gene (INSR), which is mapped to 19p13.2. RMS is characterized by acanthosis nigricans, generalized lanugo, tooth and nail dysplasia, high nasal bridge and growth retardation. Read More

    Ovarian morphology is associated with insulin resistance in women with polycystic ovary syndrome: a cross sectional study.
    Fertil Res Pract 2017 30;3. Epub 2017 May 30.
    Center for Reproductive Health, University of California at San Francisco, 2356 Sutter Street, San Francisco, 94115 CA USA.
    Background: Polycystic ovary syndrome (PCOS) is a very common disorder well known to be associated with insulin resistance and metabolic disease. Insulin resistance is likely involved in the promotion of the PCOS reproductive phenotype and may mediate some of the ovarian morphology seen in the disorder. The phenotype of each individual woman with PCOS can vary widely as can her metabolic risk. Read More

    Familial partial lipodystrophy and proteinuric renal disease due to a missense c.1045C > T LMNA mutation.
    Endocrinol Diabetes Metab Case Rep 2017 2;2017. Epub 2017 Jun 2.
    Departments of Endocrinology.
    Proteinuric renal disease is prevalent in congenital or acquired forms of generalized lipodystrophy. In contrast, an association between familial partial lipodystrophy (FPLD) and renal disease has been documented in very few cases. A 22-year-old female patient presented with impaired glucose tolerance, hyperinsulinemia, hirsutism and oligomenorrhea. Read More


    Mutation c.943G>T (p.Ala315Ser) in FGFR2 Causing a Mild Phenotype of Crouzon Craniofacial Dysostosis in a Three-Generation Family.
    Mol Syndromol 2017 Mar 13;8(2):93-97. Epub 2017 Jan 13.
    Institute of Human Genetics, University of Würzburg, Würzburg, Germany.
    Crouzon syndrome craniofacial dysostosis type I [OMIM 123500] is caused by mutations in the gene encoding fibroblast growth factor receptor-2 (FGFR2). An overlapping phenotype with Muenke and Crouzon syndrome with acanthosis nigricans (FGFR3 mutations) is known. The clinical diagnosis can be corroborated by molecular studies in about 80-90% of the cases. Read More

    Cardiometabolic profile of obese children in a sub-Saharan African setting: a cross-sectional study.
    BMC Pediatr 2017 May 19;17(1):129. Epub 2017 May 19.
    Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.
    Background: Cardiovascular and metabolic consequences of obesity in children, unlike adults, are still not well understood nor have they been subject to extensive research in Africa. We aimed to identify the cardio-metabolic complications associated with childhood obesity at the early phase of the management of obese children in a reference center in Cameroon.

    Methods: In this cross-sectional study conducted from November 2013 to September 2014 and based on World Health Organization (WHO) classification of Obesity (BMI > 3SD under 5 years and BMI > 2SD from 5 and above), we included children aged 3 to 17 years who were being followed up for obesity at the pediatric endocrinology unit of the Mother and Child Center of the Chantal BIYA Foundation in Yaounde, Cameroon. Read More

    Obstructive sleep apnea and dermatologic disorders.
    Clin Dermatol 2017 May - Jun;35(3):319-327. Epub 2017 Jan 21.
    Department of Medicine, University of Toronto School of Medicine, 645 Windermere Road, London, Ontario, Canada, N5X 2P1.
    Obstructive sleep apnea (OSA) is present in at least 2% of women and 4% of men, and its prevalence is increasing, because a major predisposing factor for OSA is a high body mass index. Psoriasis has the most strongly substantiated link with OSA, where the relationship may be bidirectional. Dermatologic disorders may be comorbid with OSA due to several factors: (i) the heightened proinflammatory state in OSA, which can occur independent of body mass index, and may exacerbate inflammatory dermatoses; (ii) intermittent hypoxemia may promote neovascularization and tumor growth in certain cancers, such as melanoma; (iii) obesity, present in majority of OSA patients, can be associated with a heightened proinflammatory state; (iv) upper airway obstruction due to local tumors or soft tissue swelling due to physical urticaria or angioedema; (v) acute nasal congestion in the atopic patient with allergic rhinitis; (vi) dermatologic disorders associated with other OSA risk factors (eg, acanthosis nigricans and metabolic syndrome); and (vii) a high sympathetic tone (eg, in atopic dermatitis) and resultant sleep fragmentation contributing to upper airway instability during sleep. Read More

    Arterial stiffening, insulin resistance and acanthosis nigricans in a community sample of adolescents with obesity.
    Int J Obes (Lond) 2017 Sep 3;41(9):1454-1456. Epub 2017 May 3.
    General and Adolescent Paediatrics, UCL Institute of Child Health, London, UK.
    Acanthosis Nigricans (AN) is a common finding in adolescents with obesity. Little is known about its relevance for cardiovascular (CVS) risk, in particular arterial stiffening. We investigated associations between AN, conventional markers of CVS risk and carotid-radial pulse wave velocity (PWV) in a community sample of adolescents with obesity aged 12-19 recruited to an obesity trial. Read More

    Prepubertal Childhood Onset Type 2 Diabetes Mellitus: Four Case Reports.
    J Assoc Physicians India 2017 Feb;65(2):43-46
    President, Madras Diabetes Research Foundation & Chairman, Dr. Mohan's Diabetes Specialities Centre, Chennai, Tamil Nadu.
    Background: The prevalence of childhood onset type 2 diabetes (T2D) is increasing, but prepubertal T2D is still unusual.

    Methods: We report four cases of T2D with onset at or below 10 years of age registered at a tertiary diabetes centre in southern India.T2D was diagnosed based on the absence of ketosis, good beta cell reserve as shown by the C peptide assay, absence of GAD antibodies and pancreatic calculi, and response to oral hypoglycemic agents. Read More

    Association of metabolic syndrome with low birth weight, intake of high-calorie diets and acanthosis nigricans in children and adolescents with overweight and obesity.
    Endocrinol Diabetes Nutr 2017 Jan 19;64(1):11-17. Epub 2017 Jan 19.
    Maestría en Nutrición Clínica, Universidad del Valle de Atemajac, Zapopan, México; Departamento de Clínicas Médicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México; Laboratorio de Inmunodeficiencias y Retrovirus Humanos, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, México. Electronic address:
    Objective: The theory of fetal programming suggests that low birth weight (LBW) predisposes to greater food intake and increases the chance of overweight and obesity, which are in turn associated to conditions such as metabolic syndrome (MS) and acanthosis nigricans. The study objective was to ascertain whether an association exists between MS, LBW, intake of high-calorie diets, and acanthosis nigricans in children and adolescents with overweight or obesity.

    Material And Methods: A case-control was conducted on 100 children who attended the overweight and obesity outpatient clinic of the OPD Hospital Civil de Guadalajara "Fray Antonio Alcalde". Read More

    Severe, Malignant Acanthosis Nigricans Associated with Adenocarcinoma of the Endometrium in a Young Obese Female.
    Case Rep Dermatol 2017 Jan-Apr;9(1):30-37. Epub 2017 Feb 10.
    Department of Dermatology, Mater Misericordiae Hospital, Brisbane, QLD, Australia.
    Acanthosis nigricans (AN) is a dermatopathy associated with insulin-resistance, drugs, endocrine disorders, chromosomal abnormalities (benign AN), and neoplasia (malignant AN). Malignant AN (MAN) is a rare paraneoplastic skin syndrome most commonly associated with gastric adenocarcinoma and other intra-abdominal malignancies. We report the case of a 28-year-old female with AN associated with obesity, insulin resistance, and endometrial adenocarcinoma. Read More

    Cutaneous Manifestations of Polycystic Ovary Syndrome: A Cross-Sectional Clinical Study.
    Indian Dermatol Online J 2017 Mar-Apr;8(2):104-110
    Department of Dermatology, STD and Leprosy, GMC Srinagar and associated SMHS Hospital, Srinagar, Jammu and Kashmir, India.
    Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS.

    Aim: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes. Read More

    The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices.
    Int J Endocrinol 2017 7;2017:5438157. Epub 2017 Mar 7.
    Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Read More

    Concomitant confluent and reticulated papillomatosis and acanthosis nigricans in an obese girl with insulin resistance successfully treated with oral minocycline: Case report and published work review.
    J Dermatol 2017 Aug 11;44(8):954-958. Epub 2017 Mar 11.
    Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.
    Concomitant confluent and reticulated papillomatosis (CRP) and acanthosis nigricans (AN) is rare. We present a case of concomitant CRP and obesity-associated AN in a 12-year-old obese Japanese girl. Curiously, oral minocycline therapy, which has been shown to be effective for CRP, was effective against both CRP and AN. Read More

    Hormonal therapies for acne.
    Clin Dermatol 2017 Mar - Apr;35(2):168-172. Epub 2016 Oct 27.
    Department of Dermatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
    Acne is a common, worldwide problem that is usually multifactorial in etiology, but androgens may play a pivotal role in the development and severity of acne. Endocrinopathies, such as polycystic ovarian syndrome, ovarian tumors, or adrenal hyperplasia or tumors, may be detected in some patients with acne, especially if acne is sudden in onset, associated with hirsutism or menstrual irregularities, or associated with cushingoid facies, acanthosis nigricans, patterned hair loss, or deepened voice. In these instances, serum-free and total testosterone, dehydroepiandrosterone, luteinizing hormone, and follicle stimulating hormone should be tested. Read More

    Sex hormones and acne.
    Clin Dermatol 2017 Mar - Apr;35(2):130-137. Epub 2016 Oct 27.
    IZZ-Immunologie Zentrum Zürich, Walchestr. 11, CH 8006, Zürich, Switzerland; Department of Dermatology and Allergy, Technische Universität München, Biedersteinerstr. 29, D-80802, Munich, Germany. Electronic address:
    The skin is an endocrine organ with the expression of metabolizing enzymes and hormone receptors for diverse hormones. The sebaceous gland is the main site of hormone biosynthesis, especially for androgens, and acne is the classical androgen-mediated dermatosis. In sebocytes, conversion of 17-hydroxyprogesterone directly to dihydrotestosterone bypassing testosterone has been demonstrated, while type II 17β-hydroxysteroid dehydrogenase can inactivate the action of testosterone and dihydrotestosterone. Read More

    Type B Insulin Resistance in Peru.
    Am J Med Sci 2017 Mar 30;353(3):258-262. Epub 2016 Aug 30.
    Endocrinology Unit, Hospital Nacional Arzobispo Loayza, Lima, Peru.
    Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. Read More

    Confluent and Reticulated Papillomatosis With Linear Pseudo-striae: A Description of 20 Cases.
    Actas Dermosifiliogr 2017 Mar 2. Epub 2017 Mar 2.
    E.S.E Centro Dermatológico Federico Lleras Acosta, Bogotá D.C., Colombia; Fundación Universitaria Sanitas, Bogotá D.C., Colombia.
    Confluent and reticulated papillomatosis, also known as Gougerot-Carteaud Syndrome, is a rare chronic disease typically affecting young adults. Of unknown etiology, the condition is characterised by oval grayish-brown or erythematous papules that coalesce to form a reticular pattern, usually on the trunk, especially in the intermammary or interscapular region and on the neck. Diagnosis is primarily clinical, based on the appearance of the lesions, the areas affected, and the response to treatment with minocycline. Read More

    Diabetes mellitus and the skin.
    An Bras Dermatol 2017 Jan-Feb;92(1):8-20
    Department of Dermatology and Radiotherapy - Faculdade de Medicina de Botucatu - Universidade Estadual Paulista "Júlio de Mesquita Filho" (UNESP) -Botucatu (SP), Brazil.
    Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Molecular mechanisms of insulin resistance in 2 cases of primary insulin receptor defect-associated diseases.
    Pediatr Diabetes 2017 Feb 9. Epub 2017 Feb 9.
    Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.
    Background: Defects of the insulin receptor gene ( INSR ) cause wide spectra of congenital insulin resistance. Monoallelic defects result in milder insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN, type A). Whereas, leprechaunism (Donahue syndrome), the most severe condition with lethality during the infantile period is caused by biallelic defects of INSR . Read More

    Mild achondroplasia/hypochondroplasia with acanthosis nigricans, normal development, and a p.Ser348Cys FGFR3 mutation.
    Am J Med Genet A 2017 Apr 9;173(4):1097-1101. Epub 2017 Feb 9.
    Division of Genetics and Metabolism, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
    Pathogenic allelic variants in the fibroblast growth factor receptor 3 (FGFR3) gene have been associated with a number of phenotypes including achondroplasia, hypochondroplasia, thanatophoric dysplasia, Crouzon syndrome with acanthosis nigricans (Crouzonodermoskeletal syndrome), and SADDAN (severe achondroplasia with developmental delay and acanthosis nigricans). Crouzon syndrome with acanthosis nigricans is caused by the pathogenic variant c.1172C>A (p. Read More

    A study of the association of acanthosis nigricans with subclinical atherosclerosis.
    Indian J Dermatol Venereol Leprol 2017 Mar-Apr;83(2):190-194
    Cardiovascular Research Unit, CUCS, University of Guadalajara, Guadalajara, Jalisco, México.
    Background: Hyperinsulinism is related to the presence of acanthosis nigricans and atherosclerosis; however, we were unable to find any study on the prevalence of atherosclerosis in acanthosis nigricans.

    Aims: To evaluate the prevalence of carotid atherosclerosis and metabolic alterations in Mexican patients with acanthosis nigricans.

    Methods: We carried out a cross-sectional study that included 45 patients with acanthosis nigricans, age- and gender-matched with 45 healthy participants. Read More

    Diagnostic and management challenges from childhood, puberty through to transition in severe insulin resistance due to insulin receptor mutations.
    Pediatr Diabetes 2017 Jan 17. Epub 2017 Jan 17.
    Department of Paediatric Endocrinology and Diabetes, Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.
    Two Caucasian girls, both of normal weight and body mass indices, were diagnosed with type A insulin resistance (IR) in childhood. Case 1 presented with premature adrenarche aged 7 years, then by age 12 years had hirsutism, acne, acanthosis nigricans, and asymptomatic diabetes. Subsequent investigation revealed raised adiponectin (15. Read More

    Acanthosis Nigricans as a Clinical Predictor of Insulin Resistance in Obese Children.
    Pediatr Gastroenterol Hepatol Nutr 2016 Dec 28;19(4):251-258. Epub 2016 Dec 28.
    Department of Pediatrics, Chosun University School of Medicine, Gwangju, Korea.
    Purpose: This study aimed to evaluate the utility of acanthosis nigricans (AN) severity as an index for predicting insulin resistance in obese children.

    Methods: The subjects comprised 74 obese pediatric patients who attended the Department of Pediatrics at Chosun University Hospital between January 2013 and March 2016. Waist circumference; body mass index; blood pressure; fasting glucose and fasting insulin levels; lipid profile; aspartate transaminase, alanine transaminase, glycated hemoglobin, C-peptide, and uric acid levels; and homeostatic model assessment insulin resistance (HOMA-IR) and quantitative insulin check sensitivity index (QUICKI) scores were compared between subjects with AN and those without AN. Read More

    Glucagon-like peptide-1 analogues - an efficient therapeutic option for the severe insulin resistance of lipodystrophic syndromes: two case reports.
    J Med Case Rep 2017 Jan 13;11(1):12. Epub 2017 Jan 13.
    Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, Alameda Prof. Hernâni Monteiro, 4200, Porto, Portugal.
    Background: Lipodystrophic syndromes are uncommon medical conditions which are normally associated with metabolic disorders, such as diabetes mellitus, dyslipidemia, and fatty liver disease. These complications are generally difficult to treat, particularly diabetes, due to severe insulin resistance. We present two case reports of successful treatment of diabetes with glucagon-like peptide-1 analogues in patients with clinical features of lipodystrophic syndromes. Read More

    The Clinical Characteristics of Obese Patients with Acanthosis Nigricans and Its Independent Risk Factors.
    Exp Clin Endocrinol Diabetes 2017 Mar 12;125(3):191-195. Epub 2017 Jan 12.
    Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Objective: This study aimed to investigate the clinical characteristics and risk factors for acanthosis nigricans (AN) in obese patients. Methods: 80 obese patients without AN (OB group) and 128 obese patients with AN (AN group) were included in this study. Clinical data for each patients were collected. Read More

    Triglyceride to HDL-C Ratio is Associated with Insulin Resistance in Overweight and Obese Children.
    Sci Rep 2017 Jan 6;7:40055. Epub 2017 Jan 6.
    Diabetes and Endocrine Unit, Institute For Medical Research, Kuala Lumpur, Malaysia.
    The purpose of this study was to investigate the usefulness of triglyceride to hdl-c ratio (TG:HDL-C) as an insulin resistance (IR) marker for overweight and obese children. A total of 271 blood samples of obese and overweight children aged 9-16 years were analysed for fasting glucose, lipids and insulin. Children were divided into IR and non-insulin resistance, using homeostasis model assessment (HOMA). Read More

    Double diabetes in Saudi Arabia: A new entity or an underestimated condition.
    World J Diabetes 2016 Dec;7(20):621-626
    Rim Braham, Aus Alzaid, Asirvatham Alwin Robert, Rania Ahmad Ahmad, Mohamed Abdulaziz Al Dawish, Department of Endocrinology and Diabetes, Prince Sultan Military Medical City, Riyadh 11159, Saudi Arabia.
    Aim: To determine the clinical and biological characteristics of double diabetes (DD) among young people in Saudi Arabia.

    Methods: This was a retrospective descriptive chart review study including 312 young newly diagnosed diabetic patients (aged 12-20 years), whom were admitted over a five year period (January 2009 to December 2013). Family history of diabetes mellitus (DM) (first degree), physical body mass index (BMI), acanthosis nigricans, history of auto-immune disease and laboratory information for glycosylated hemoglobin, basal C peptide level and diabetes autoantibody response (anti-GAD, anti-IA2 and anti-ICA) were collected from medical report. Read More

    Acanthosis nigricans in obese adolescents: prevalence, impact, and management challenges.
    Adolesc Health Med Ther 2017 16;8:1-10. Epub 2016 Dec 16.
    Department of Paediatrics and Adolescent Medicine, Tseung Kwan O Hospital, Tseung Kwan O, Hong Kong, China.
    Obesity in adolescence is a public health priority because it usually tracks into adulthood, resulting in enormous medical and social costs. This underscores the importance of early identification and intervention. Acanthosis nigricans (AN) was once considered a rare paraneoplastic dermatosis, but is now frequently observed in obese adolescents. Read More

    Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin.
    Pediatr Dermatol 2017 Mar 23;34(2):160-162. Epub 2016 Dec 23.
    Department of Dermatology, School of Medicine, Yale University, New Haven, Connecticut.
    Costello syndrome (CS) is a multisystem congenital disorder characterized by coarse facial features, cardiac defects, intellectual disability, and predisposition to malignancies. Dermatologic findings can include cutaneous papillomas, skin redundancy, acanthosis nigricans, and keratosis pilaris. Palmoplantar keratoderma (PPK) is present in approximately 76% of patients with CS, with disabling functional consequences in severe cases. Read More

    Specific skin signs as a cutaneous marker of diabetes mellitus and the prediabetic state - a systematic review.
    Dan Med J 2017 Jan;64(1)
    Introduction: Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD). These conditions possibly relate to underlying diabetogenic mechanisms. Read More

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