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Front Endocrinol (Lausanne) 2021 23;12:662725. Epub 2021 Apr 23.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Background: Previous studies suggest that the vaginal microbiome is associated with polycystic ovary syndrome (PCOS). However, the clinical manifestations of PCOS are heterogeneous. Whether the vaginal microbiome is related with different clinical symptoms was unknown. Read More

Indian Dermatol Online J 2021 Mar-Apr;12(2):244-249. Epub 2021 Mar 2.

Department of Dermatology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Background: Periorbital melanosis (PM) is one of the most common dermatological condition seen in routine practice. Several cutaneous markers such as acanthosis nigricans have been associated with insulin resistance (IR). However, the association of PM with IR needs to be substantiated. Read More

Arch Dis Child 2021 Apr 30. Epub 2021 Apr 30.

University of Trieste, Trieste, Italy.

J Eur Acad Dermatol Venereol 2021 Apr 30. Epub 2021 Apr 30.

Inserm UMR1231 GAD, Génétique des Anomalies du Développement, Université de Bourgogne, 21079, Dijon, France.

Background: Postzygotic mutations in FGFR2 have been identified in mosaic forms of acne, keratinocytic epidermal nevi, nevoid acanthosis nigricans / rounded and velvety epidermal nevus and in two fetuses with papillomatous pedunculated sebaceous nevus (PPSN).

Objectives: To determine the clinical and genetic characteristics of children with cerebriform, papillomatous, and pedunculated variants of sebaceous nevi.

Methods: Infants diagnosed with sebaceous nevi characterized by a cerebriform, papillomatous, and/or pedunculated morphology over a 10-year period (2010 - 2019) at three pediatric dermatology centers in Switzerland and France were included in this case series. Read More

Indian J Dermatol 2021 Jan-Feb;66(1):60-66

Department of Dermatology, Venereology and Leprosy, College of Medicine and Sagore Dutta Hospital, Kolkata, West Bengal, India.

Background: Acne vulgaris is a common dermatological disorder. Several hormones are suspected to play a role in its etiopathogenesis.

Aims And Objectives: The aim of this study was to analyze the role of sex-hormones, metabolic status, and obesity in acne vulgaris and correlate with its severity and symptom load. Read More

Diabetes Metab Syndr 2021 Apr 8;15(3):901-907. Epub 2021 Apr 8.

Campania University "Luigi Vanvitelli", Naples, Italy; Nefrocenter Research Network & Nyx Research Start-Up, Naples, Italy.

Background: Policaptil Gel Retard® (PGR), is a new macromolecule complex based on polysaccharides slowing the rate of carbohydrate and fat absorption. It proved to significantly reduce body weight, acanthosis nigricans expression, HbA1c levels, and glucose metabolism abnormalities in obese, hyper-insulinemic adolescents. No such data are available for adults. Read More

Cutis 2021 Feb;107(2):74-78

Mr. Svoboda is from the Virginia Tech Carilion School of Medicine, Roanoke. Dr. Shields is from the Department of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison.

Hyperglycemia is defined by excess blood glucose and, when persistent, may lead to prediabetic and diabetic states. Insulin is a hormone produced by the beta cells of the pancreas in response to elevated blood glucose. Dysregulated insulin secretion or clearance results in hyperinsulinemia, which also is closely associated with type 2 diabetes mellitus (T2DM) and metabolic disturbances. Read More

J Pediatr Endocrinol Metab 2021 Apr 6. Epub 2021 Apr 6.

Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX, USA.

Objectives: Given their established role in hepatic function and insulin resistance for adults, early screening of type 2 diabetes mellitus (T2DM) in the pediatric population may potentially be improved by the assessment of elevated liver enzymes.

Methods: Our study enrolled 151 nondiabetic children aged 10-14 years. Patients were assessed for demographics and five risk factors for T2DM. Read More

J Pediatr Adolesc Gynecol 2021 Mar 29. Epub 2021 Mar 29.

Department of Pediatrics, Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado; Center for Women's Health Research, University of Colorado Anschutz Medical Campus, Aurora, Colorado. Electronic address:

Study Objective: Based on updated guidelines and expressed patient needs, we created a multidisciplinary clinic including endocrinology, gynecology/adolescent medicine, dermatology, psychology, and nutrition to provide comprehensive care to adolescent girls with polycystic ovary syndrome (PCOS). We describe the patient population presenting to this clinic, and prescribing patterns when a multidisciplinary approach is used.

Design: Retrospective chart review. Read More

N Engl J Med 2021 Apr;384(13):e50

J Cosmet Dermatol 2021 Mar 22. Epub 2021 Mar 22.

Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Treatment of acanthosis nigricans (AN) is challenging, and new modalities are being explored continuously to increase the therapeutic efficacy.

Aim: To evaluate the efficacy and safety of fractional CO2 laser compared to trichloroacetic acid (TCA) peel in the treatment of pseudo-acanthosis nigricans (pseudo-AN).

Methods: The study included 40 patients with pseudo-AN on the neck and axilla allocated into two groups each containing 20 patients. Read More

Dermatol Clin 2021 Apr 12;39(2):175-182. Epub 2021 Feb 12.

Nail Disease Centre, Rue des Serbes 42, Cannes 06400, France.

The cutaneous paraneoplastic syndromes are rare and intrinsically devoid of any neoplastic nature. The manifestations on the skin and the nails are due to various mechanisms caused by the tumor, either due to production of bioactive substances or in response to it. These disorders evolve in parallel to the malignancy, in that, they regress when the tumor is removed and reappear in the case of tumor recurrence. Read More

Biomed Res Int 2021 25;2021:8878149. Epub 2021 Feb 25.

Department of Endocrinology, Shenzhen Hospital, Southern Medical University, Shenzhen 518100, China.

Background: Mutations in insulin receptor genes can cause severe insulin resistance syndrome. Compared with Rabson-Mendenhall Syndrome and Donohue's Syndrome, type A insulin resistance syndrome is generally not serious. The main manifestations in woman with type A insulin resistance syndrome are hyperinsulinemia, insulin resistance, acanthosis nigricans, hyperandrogenism, and polycystic ovary. Read More

Hautarzt 2021 Apr 3;72(4):295-298. Epub 2021 Mar 3.

Klinik für Dermatologie und Allergologie, Hautklinik, Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Background: Hyperplasia-associated cutaneous paraneoplasia is an important differential diagnosis in everyday clinical practice. An early diagnosis of the underlying tumor disease can significantly improve the patient's prognosis.

Pathogenesis: Hyperplasia is probably mainly cytokine-mediated. Read More

Curr Probl Cardiol 2021 May 24;46(5):100799. Epub 2021 Jan 24.

Department of Medicine, Division of Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN.

Chronic systemic skin disease and cardiovascular disease are multisystem disorders which have been associated with each other for centuries. Recent research has strengthened this association, particularly in systemic inflammatory disease. Here we explore the current literature on psoriasis, hidradenitis suppurativa, lupus erythematosus, acanthosis nigricans, atopic dermatitis, and bullous pemphigoid. Read More

Onco Targets Ther 2021 10;14:951-957. Epub 2021 Feb 10.

Department of Dermatology, The Second Hospital of Dalian Medical University, Dalian, Liaoning, 116027, People's Republic of China.

Acanthosis nigricans (AN) is a rare cutaneous condition that may be a manifestation of certain endocrinological or autoimmune diseases, as well as a potential marker for underlying undiagnosed cancer. AN is classified as either benign or malignant based on its clinical associations. Malignant acanthosis nigricans (MAN), which tends to be extensive and develops rapidly, is considered to be a paraneoplastic syndrome associated with advanced cancer, commonly accompanied by intra-abdominal malignancies. Read More

Endocrinol Diabetes Metab Case Rep 2021 Feb 17;2021. Epub 2021 Feb 17.

Endocrinology Unit, Department of Internal Medicine, Queen Elizabeth Hospital, Kota Kinabalu, Sabah, Malaysia.

Summary: Polycystic ovarian syndrome (PCOS) is associated with menstrual irregularities, ovulatory dysfunction, hirsutism, insulin resistance, obesity and metabolic syndrome but is rarely associated with severe hyperandrogenaemia and virilisation resulting in male pattern baldness and clitoromegaly. Total serum testosterone greater than twice the upper limit of the reference range or free androgen index of over five-fold elevated suggests a diagnosis other than PCOS. We reported a case of a 15 years old obese girl presented with secondary amenorrhoea, virilising signs: frontal baldness, clitoromegaly and prominent signs of insulin resistance and marked acanthosis nigricans. Read More

J Pediatr Endocrinol Metab 2020 Dec 20;33(12):1563-1568. Epub 2020 Nov 20.

Necmettin Erbakan University Faculty of Medicine, Division of Pediatric Endocrinology, Konya, Turkey.

Objectives: Acanthosis nigricans is a skin symptom in obesity that helps to identify patients at high risk for dyslipidemia, hypertension, insulin resistance, and diabetes. It is the most important complication of obesity in metabolic syndrome. Studies investigating the relationship between acanthosis nigricans and metabolic syndrome in obese children are insufficient. Read More

J Hum Genet 2021 Feb 12. Epub 2021 Feb 12.

Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.

FGFR3 encodes a transmembrane receptor tyrosine kinase that has six autophosphorylation sites of tyrosine. Among them, Y770 is a negative regulatory site for the downstream signaling of FGFR3. Constitutive active mutations in FGFR3 are involved in human developmental disorders including familial acanthosis nigricans, an autosomal dominant disorder characterized by general hyperpigmentation with mild acanthosis of the epidermis. Read More

Case Rep Gastroenterol 2020 Sep-Dec;14(3):702-706. Epub 2020 Dec 16.

Division of Gastroenterology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.

Acanthosis nigricans with tripe palms is one of the skin manifestations of systemic conditions, as well as internal malignancy. There have been reports of this paraneoplastic condition's association with orocutaneous papillomatosis, but investigations into its relationship with diffuse esophageal papillomatosis are scarce. We report a case of acanthosis nigricans with tripe palms that was associated with diffuse esophageal squamous papillomatosis. Read More

BMJ Case Rep 2021 Feb 10;14(2). Epub 2021 Feb 10.

Paediatric, Hospital de Braga, Braga, Portugal.

J Dermatol 2021 Apr 4;48(4):e155-e156. Epub 2021 Feb 4.

Department of Dermatology, Soonchunhyang University Hospital, Seoul, South Korea.

J Diabetes Metab Disord 2020 Dec 16;19(2):989-996. Epub 2020 Sep 16.

General Practice, 66650 Banuyls-sur-Mer, France.

Introduction: Although type 2 diabetes mellitus (DM) is a global public health problem, the diabetes-associated dermatological (non-infectious) manifestations (DADM) remain poorly understood and under-diagnosed. We aimed to evaluate the prevalence of 7 known DADM in a primary care setting, and their association macro/microvascular complications.

Methods: Cross-sectionnal study included patients consulting in general practice for DM-follow up, from November 2016 to January 2017. Read More

J Am Acad Dermatol 2021 Jan 28. Epub 2021 Jan 28.

Department of Dermatology, Universidade Federal de São Paulo, Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, São Paulo, Brazil.

Lab Med 2021 Jan 29. Epub 2021 Jan 29.

Genetic Metabolic Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

The clinical manifestations of FGFR3 sequence variations can vary from mild unnoticed short stature to neonatal lethal dwarfism and can be causative of phenotypes including achondroplasia, hypochondroplasia, and thanatophoric dysplasia. Clinical data describe an 11 month old girl with restricted growth and preserved intellect. She had rhizomelic short stature with peculiar facies but no Acanthosis nigricans. Read More

Int J Environ Res Public Health 2021 01 22;18(3). Epub 2021 Jan 22.

School of Nursing, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ 20551-030, Brazil.

Background: Labor activities are demanding for workers and can induce occupational stress. Primary health care (PHC) workers have faced problems that can lead to the development of stress and abdominal obesity. The aim of this study was to estimate the prevalence of abdominal adiposity among primary health care physicians in the metropolitan mesoregion of Salvador, Bahia. Read More

Diabetes Metab Res Rev 2021 May 22;37(4):e3441. Epub 2021 Feb 22.

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

Aims: To determine the relationship between thyroid markers during pregnancy and gestational diabetes mellitus (GDM) or post-partum glucose metabolism.

Materials And Methods: Based on pregnancy 75-g oral glucose tolerance test (OGTT) results, 1467 subjects were grouped into normal glucose tolerance (NGTp; n = 768) and GDM (n = 699) groups. Furthermore, based on post-partum 75-g OGTT results, 286 GDM subjects, screened for glucose metabolism after delivery, were grouped into NGTd (n = 241) and abnormal glucose tolerance (AGT; n = 45) groups. Read More

Dermatol Ther 2021 Mar 4;34(2):e14794. Epub 2021 Feb 4.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Drug-induced acanthosis nigricans is an uncommon subtype of acanthosis nigricans and the data on this topic is not well understood by clinicians as it is presently limited in the literature. Previous reports of drug-induced acanthosis nigricans have simply consisted of a list of drugs possibly implicated in causing acanthosis nigricans. Several drugs listed are based on single case reports without biopsy confirmation, report of clearing on stopping the drug or reporting on whether acanthosis nigricans recurred with drug rechallenge. Read More

Dermatology 2021 Jan 14:1-9. Epub 2021 Jan 14.

Department of Skin and VD, SMS Medical College and Hospital, Jaipur, India,

Background: Whether HAIR-AN syndrome and polycystic ovarian syndrome (PCOS) are distinct entities or represent a phenotypic spectrum of the same syndrome is still unclear. HAIR-AN syndrome is characterized by high insulin resistance, obesity, and hyperinsulinemia as compared to PCOS and could represent adipose tissue dysfunction as the primary pathophysiologic trigger. This study was undertaken to study the role of adipose tissue dysfunction in HAIR-AN syndrome and PCOS using adipocytokines as surrogate markers of "adiposopathy. Read More

Endocrinol Diabetes Metab Case Rep 2020 Oct 14;2020. Epub 2020 Oct 14.

Division of Endocrinology, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru.

Summary: Type B insulin resistance syndrome (TBIR) is a rare autoimmune disease caused by antibodies against the insulin receptor. It should be considered in patients with dysglycaemia and severe insulin resistance when other more common causes have been ruled out. We report a case of a 72-year-old male with a 4-year history of type 2 diabetes who presented with hypercatabolism, vitiligo, acanthosis nigricans, and hyperglycaemia resistant to massive doses of insulin (up to 1000 U/day). Read More