213,096 results match your criteria Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry[Journal]


Variation in hospital charges in patients with external ventricular drains: comparison between the intensive care and surgical floor settings.

J Neurosurg Pediatr 2019 Apr 19:1-6. Epub 2019 Apr 19.

3Department of Neurosurgery, University of Washington School of Medicine, Seattle, Washington.

OBJECTIVEPlacement of an external ventricular drain (EVD) is a common and potentially life-saving neurosurgical procedure, but the economic aspect of EVD management and the relationship to medical expenditure remain poorly studied. Similarly, interinstitutional practice patterns vary significantly. Whereas some institutions require that patients with EVDs be monitored strictly within the intensive care unit (ICU), other institutions opt primarily for management of EVDs on the surgical floor. Read More

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https://thejns.org/view/journals/j-neurosurg-pediatr/aop/art
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http://dx.doi.org/10.3171/2019.2.PEDS18545DOI Listing
April 2019
1 Read

Augmented and virtual reality in dental medicine: A systematic review.

Comput Biol Med 2019 Mar 15;108:93-100. Epub 2019 Mar 15.

Department of Reconstructive Dentistry, University Center for Dental Medicine Basel, University of Basel, Switzerland, Hebelstr. 3, CH-4056, Basel, Switzerland.

Background: The aim of this systematic review was to provide an update on the contemporary knowledge and scientific development of augmented reality (AR) and virtual reality (VR) in dental medicine, and to identify future research needs to accomplish its clinical translation.

Method: A modified PICO-strategy was performed using an electronic (MEDLINE, EMBASE, CENTRAL) plus manual search up to 12/2018 exploring AR/VR in dentistry in the last 5 years. Inclusion criteria were limited to human studies focusing on the clinical application of AR/VR and associated field of interest in dental medicine. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.012DOI Listing

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 16. Epub 2019 Apr 16.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
2 Reads

Compromising human skin in vivo and ex vivo to study skin barrier repair.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Drug Delivery Technology, Cluster BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. Electronic address:

Ex vivo regenerated stratum corneum (SC) after tape-stripping can be used as a model to study the barrier function of compromised skin. Yet, details about how close the regenerated SC model mimics the lipid properties (e.g. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.005DOI Listing

The Evaluation of Emotional Intelligence among Medical Students and Its Links with Non-cognitive Acceptance Measures to Medical School.

Rambam Maimonides Med J 2019 Apr 18;10(2). Epub 2019 Apr 18.

The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Background: The importance of emotional intelligence (EI) to the success of health professionals has been increasingly acknowledged. Concurrently, medical schools have begun integrating non-cognitive measures in candidate selection processes. The question remains whether these newly added processes correctly assess EI skills. Read More

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http://dx.doi.org/10.5041/RMMJ.10365DOI Listing
April 2019
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Enhancing Understanding of Moral Distress: The Measure of Moral Distress for Health Care Professionals.

AJOB Empir Bioeth 2019 Apr 19:1-12. Epub 2019 Apr 19.

e School of Nursing , Virginia Commonwealth University , Richmond , Virginia , USA.

Background: As ongoing research explores the impact of moral distress on health care professionals (HCPs) and organizations and seeks to develop effective interventions, valid and reliable instruments to measure moral distress are needed. This article describes the development and testing of a revision of the widely used Moral Distress Scale-Revised (MDS-R) to measure moral distress.

Methods: We revised the MDS-R by evaluating the combined data from 22 previous studies, assessing 301 write-in items and 209 root causes identified through moral distress consultation, and reviewing 14 recent publications from various professions in which root causes were described. Read More

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http://dx.doi.org/10.1080/23294515.2019.1586008DOI Listing

The importance of respiratory rate monitoring.

Authors:
Sandy Rolfe

Br J Nurs 2019 Apr;28(8):504-508

Respiratory Nurse Specialist, NHS Tayside and Clinical Academic Lecturer, School of Nursing and Health Sciences, University of Dundee.

Respiratory rate measurement is regarded as a core nursing skill. Yet there are numerous recorded discrepancies in the monitoring and assessment of patients' respiratory rate. This article discusses the importance of respiration rate in terms of patient clinical outcomes, monitoring and documentation. Read More

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http://dx.doi.org/10.12968/bjon.2019.28.8.504DOI Listing

HOUR Prediction Rule - Letter to the Editor.

Acad Emerg Med 2019 Apr 19. Epub 2019 Apr 19.

Lehigh Valley Health Network, Department of Emergency and Hospital Medicine, Division of Medical Toxicology, Allentown, PA.

In a recent issue of Academic Emergency Medicine, we read with interest the article titled: Hospital Observation Upon Reversal (HOUR) with Naloxone: A Prospective Clinical Prediction Rule Validation Study by Clemency et al. In order to avoid over-reliance on this decision rule and possible untoward effects of early discharge, we feel that there are some key points worth considering in this regard. It is important to note that the average dose of prehospital naloxone was 3. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/acem.13769
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http://dx.doi.org/10.1111/acem.13769DOI Listing
April 2019
1 Read

Workforce Support for Urban After-School Programs: Turning Obstacles into Opportunities.

Am J Community Psychol 2019 Apr 19. Epub 2019 Apr 19.

Department of Psychology, Florida International University, Miami, FL, USA.

Organized after-school programs can mitigate risk and build resilience for youth in urban communities. Benefits rely on high-quality developmental experiences characterized by a supportive environment, structured youth-adult interactions, and opportunities for reflective engagement. Programs in historically disenfranchised communities are underfunded; staff are transient, underpaid, and undertrained; and youth exhibit significant mental health problems which staff are variably equipped to address. Read More

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http://dx.doi.org/10.1002/ajcp.12328DOI Listing

Is the Sum Greater than its Parts? Variations in Substance-Related Consequences by Conjoint Alcohol-Marijuana Use Patterns.

J Psychoactive Drugs 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Psychology , Palo Alto University , Palo Alto , CA , USA.

Alcohol and marijuana are the most commonly used substances for college-attending young adults. This study evaluated differences in substance-specific consequence attribution by alcohol-marijuana use patterns (concurrent alcohol and marijuana [CAM; use of both substances, not at same time] and simultaneous [SAM; use of both, at same time]) as well as alcohol-only (AO). First-year college students with prior alcohol use (N = 610, 50. Read More

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http://dx.doi.org/10.1080/02791072.2019.1599473DOI Listing

Older Teens' Understanding and Perceptions of Risks in Studies With Genetic Testing: A Pilot Study.

AJOB Empir Bioeth 2019 Apr 19:1-9. Epub 2019 Apr 19.

d Academic and Regulatory Monitoring Services, LLC , Cincinnati , Ohio , USA.

Background: The consent process used in clinical research today falls markedly short of the ideal process envisioned nearly 30 years ago. Critics have suggested that the informed consent process has become challenging, formalistic, and incompletely understood by researchers and participants alike. Hence, the purpose of this pilot study was to identify and characterize important aspects of the informed consent process that teens believe impact their understanding of risks of participation in studies with genetic testing. Read More

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http://dx.doi.org/10.1080/23294515.2019.1577313DOI Listing

Work, Stress and Play: Students' perceptions of factors impacting on their studies and wellbeing.

Eur J Dent Educ 2019 Apr 19. Epub 2019 Apr 19.

DCT 1 Special Care Dental Services, Buckinghamshire Priority Dental Service, Eaglestone Health Centre, Standing Way, Milton Keynes, MK6 5AZ.

Introduction: This study gathered information about life outside of the course for undergraduates studying at the School of Dentistry, Cardiff University. The aim was to explore how these external factors to the course may affect an individual's academic performance and well-being.

Materials And Methods: A cross-sectional study design was used. Read More

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http://dx.doi.org/10.1111/eje.12436DOI Listing

Non-hormonal treatment for male infertility: the potential role of Serenoa repens, selenium and lycopene.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):3112-3120

Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Objective: Male infertility is a wide spread disease among couple of childbearing age. Spermatozoa are highly susceptible to oxidative stress. Reactive oxygen species (ROS) are capable of damaging the sperm membrane and DNA, inducing lipid peroxidation and sperm DNA fragmentation (SDF). Read More

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http://dx.doi.org/10.26355/eurrev_201904_17595DOI Listing

Religious and spiritual struggles, religiousness, and alcohol problems among undergraduates.

J Prev Interv Community 2019 Apr 19:1-16. Epub 2019 Apr 19.

b Bowling Green State University , Bowling Green , OH , USA.

Theoretically, religion/spirituality may protect against alcohol problems or facilitate recovery. However, challenges can arise in religious/spiritual life that may contribute to or complicate alcohol problems. Emerging adults often experience difficult transitions from family environments to independent membership in academic communities straddling the legal drinking age boundary. Read More

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https://www.tandfonline.com/doi/full/10.1080/10852352.2019.1
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http://dx.doi.org/10.1080/10852352.2019.1603678DOI Listing
April 2019
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Chrysin Inhibits Proinflammatory Factor-Induced EMT Phenotype and Cancer Stem Cell-Like Features in HeLa Cells by Blocking the NF-κB/Twist Axis.

Cell Physiol Biochem 2019 ;52(5):1236-1250

Department of Gynecology and Obstetrics, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China,

Background/aims: TNF-α and TGF-β associated epithelial-mesenchymal transition (EMT) occurs via NF-κB-dependent transcriptional upregulation of Twist1.Chrysin (ChR) is a major active ingredient ofpropolis, which inhibits various cancer cells and possesses anti-inflammatory activities. This study aimed to assess whether and how ChR inhibits proinflammatory cytokine-induced EMT phenotype and cancer stem-like cell (CSLC) features in the HeLa cell line. Read More

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https://www.cellphysiolbiochem.com/Articles/000084/
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http://dx.doi.org/10.33594/000000084DOI Listing
January 2019
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Factors associated with spontaneous stone passage in a contemporary cohort of patients presenting with acute ureteric colic. Results from the MIMIC Study (A Multi-centre cohort study evaluating the role of Inflammatory Markers In patients presenting with acute ureteric Colic).

BJU Int 2019 Apr 18. Epub 2019 Apr 18.

British Urology Researchers in Surgical Training (BURST), London, United Kingdom.

Objectives: There is conflicting data on the role of white blood cell count (WBC) and other inflammatory markers in spontaneous stone passage in patients with acute ureteric colic. The aim of the study was to assess the relationship of WBC and other routinely collected inflammatory and clinical markers including stone size, stone position and Medically Expulsive Therapy use (MET) with spontaneous stone passage (SSP) in a large contemporary cohort of patients with acute ureteric colic.

Subjects And Methods: Multi-centre retrospective cohort study coordinated by the British Urology Researchers in Surgical Training (BURST) Research Collaborative at 71 secondary care hospitals across 4 countries (United Kingdom, Republic of Ireland, Australia and New Zealand). Read More

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http://dx.doi.org/10.1111/bju.14777DOI Listing

Two is a crowd: on the enigmatic etiopathogenesis of conjoined twinning.

Clin Anat 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Biology, Sections Clinical Anatomy & Embryology, Academic Medical Center, University of Amsterdam, The Netherlands.

In this paper we provide a comprehensive overview of multiple facets in the puzzling genesis of symmetrical conjoined twins. The etiopathogenesis of conjoined twins remains matter for ongoing debate and is currently cited-in virtually every paper on conjoined twins-as partial fission or secondary fusion. Both theories could potentially be extrapolated from embryological adjustments exclusively seen in conjoined twins. Read More

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http://dx.doi.org/10.1002/ca.23387DOI Listing

The clinical presentation caused by truncating CHD8 variants.

Clin Genet 2019 Apr 18. Epub 2019 Apr 18.

Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, United Kingdom.

Variants in the chromodomain helicase DNA-binding protein 8 (CHD8) have been associated with intellectual disability (ID), autism spectrum disorders (ASD) and overgrowth and CHD8 is one of the causative genes for OGID (overgrowth and ID). We investigated 25 individuals with CHD8 protein truncating variants (PTVs), including 10 previously unreported patients and found a male to female ratio of 2.7:1 (19:7) and a pattern of common features: macrocephaly (62. Read More

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http://doi.wiley.com/10.1111/cge.13554
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http://dx.doi.org/10.1111/cge.13554DOI Listing
April 2019
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Assessment of Synthesis Machinery of Two Antimicrobial Peptides from Paenibacillus alvei NP75.

Probiotics Antimicrob Proteins 2019 Apr 17. Epub 2019 Apr 17.

Department of Biotechnology, Bharathidasan Institute of Technology, Anna University, Room No. 124, New Academic Block - B, Tiruchirappalli, Tamil Nadu, 620024, India.

Paenibacillus alvei NP75, a Gram-positive bacterium, produces two different antimicrobial peptides, paenibacillin N and P, which has potent antimicrobial activity against many clinical pathogens. The synthesis pattern of these antimicrobial peptides by P. alvei NP75 was studied extensively. Read More

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http://dx.doi.org/10.1007/s12602-019-09541-wDOI Listing

Antimicrobial Peptide JH-3 Effectively Kills Salmonella enterica Serovar Typhimurium Strain CVCC541 and Reduces Its Pathogenicity in Mice.

Probiotics Antimicrob Proteins 2019 Apr 18. Epub 2019 Apr 18.

Postdoctoral Research Base, Henan Institute of Science and Technology, Xinxiang, People's Republic of China.

Salmonella is an important zoonotic pathogen and is a major cause of gastrointestinal diseases worldwide. The current serious problem of antibiotic abuse has prompted the search for new substitutes for antibiotics. JH-3 is a small antimicrobial peptide with broad-spectrum bactericidal activity. Read More

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http://dx.doi.org/10.1007/s12602-019-09533-wDOI Listing

Past and emerging topics related to electronic waste management: top countries, trends, and perspectives.

Environ Sci Pollut Res Int 2019 Apr 18. Epub 2019 Apr 18.

Group of Applied Instrumental Analysis, Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, 13565-905, Brazil.

A bibliometric analysis was performed to assess historical and recent research trends regarding e-waste studies from 1998 to 2018. Documents related to e-waste were identified from the Clarivate Analytics Web of Science© (WoS) database, and a total of 3311 academic articles was retrieved. The analysis was performed from four main aspects: (1) publication activity by year, by WoS category, and by geographic distribution; (2) journals; (3) most-cited papers; and (4) top 10 countries and author keyword analysis. Read More

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http://dx.doi.org/10.1007/s11356-019-05089-yDOI Listing

Student Exposure to Cancer Patients: an Analysis of Clinical Logbooks and Focus Groups in Clinical Year Medical Students.

J Cancer Educ 2019 Apr 17. Epub 2019 Apr 17.

Fiona Stanley Hospital, 11 Robin Warren Dr, Murdoch, WA, 6150, Australia.

Despite cancer being the leading cause of mortality, cancer education and patient exposure are lacking in many medical schools. The aim of this study was to evaluate the nature of cancer patient exposure, relative to the clinical setting for medical students on placement and to explore their experiences. Participants were asked to maintain a logbook of cancer patient encounters and were invited to attend a structured focus group upon completion of the academic year. Read More

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http://dx.doi.org/10.1007/s13187-019-01526-1DOI Listing

Visualizing faculty development impact: A social network analysis.

Perspect Med Educ 2019 Apr 18. Epub 2019 Apr 18.

Duke-NUS Medical School, Academic Medicine Education Institute, Singapore, Singapore.

Faculty development programs have tended to focus on low levels of evaluation such as participant satisfaction rather than assess the actual changes that training has brought about in the workplace. This has prompted scholars to suggest using social network analysis as a means to provide a more rigorous method of evaluating the impact of faculty development. To test the feasibility of such a suggestion, we used the social network analysis concepts of social cohesion to assess the impact of a year-long fellowship program conducted by Duke-NUS Medical School's Academic Medicine Education Institute (AM·EI). Read More

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http://dx.doi.org/10.1007/s40037-019-0510-9DOI Listing

Improving follow up after predictive testing in Huntington's disease: evaluating a genetic counselling narrative group session.

J Community Genet 2019 Apr 18. Epub 2019 Apr 18.

Division of Evolution and Genomic Sciences, School of Biological Science, University of Manchester, Manchester, UK.

Recently updated Huntington's disease (HD) predictive testing guidelines emphasise clinicians' responsibility to facilitate emotional support following testing, regardless of the result. Yet models of post-test counselling support are poorly defined. Moreover, it is unclear how these might be best delivered. Read More

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http://dx.doi.org/10.1007/s12687-019-00416-9DOI Listing
April 2019
1 Read

Smartphone Use and Interest in a Spine Surgery Recovery Mobile Application Among Patients in a US Academic Neurosurgery Practice.

Oper Neurosurg (Hagerstown) 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurosurgery, University of Michigan, Ann Arbor, Michigan.

Background: Mobile applications (apps) are serving an increasingly important role in healthcare for patients and providers alike. In addition to streamlining active communication of patient-reported outcomes regarding quality of life, pain, and opioid consumption, smartphones equipped with activity tracking afford the opportunity to passively and objectively measure mobility, a key metric of recovery in spine surgery. However, app development is a resource-intensive process. Read More

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http://dx.doi.org/10.1093/ons/opz061DOI Listing

Changing Characteristics of Staphylococcus aureus Bacteremia: Results From a 21-Year, Prospective, Longitudinal Study.

Clin Infect Dis 2019 Apr 19. Epub 2019 Apr 19.

Department of Medicine, Duke University Medical Center, North Carolina.

Background: We conducted a longitudinal study to evaluate changes in the clinical presentation and epidemiology of Staphylococcus aureus bacteremia (SAB) in an academic, US medical center.

Methods: Consecutive patients with monomicrobial SAB were enrolled from January 1995 to December 2015. Each person's initial bloodstream S. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/cid/ciz112DOI Listing
April 2019
1 Read

Physical and geometric determinants of transport in fetoplacental microvascular networks.

Sci Adv 2019 Apr 17;5(4):eaav6326. Epub 2019 Apr 17.

School of Mathematics, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

Across mammalian species, solute exchange takes place in complex microvascular networks. In the human placenta, the primary exchange units are terminal villi that contain disordered networks of fetal capillaries and are surrounded externally by maternal blood. We show how the irregular internal structure of a terminal villus determines its exchange capacity for diverse solutes. Read More

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http://dx.doi.org/10.1126/sciadv.aav6326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469945PMC

Service-Learning as a Practical Introduction to Undergraduate Public Health: Benefits for Student Outcomes and Accreditation.

Front Public Health 2019 2;7:63. Epub 2019 Apr 2.

The Center for Community Work and Learning, St. Catherine University, St. Paul, MN, United States.

Since the mid-1980s, service-learning has gained recognition as a pedagogical model in higher education with exciting potential for students' academic, civic, and professional development (1). Deemed a high-impact educational practice by the American Association of Colleges and Universities (AAC&U), extant research points to student learning, engagement, and retention benefits from community-based experiences integrated into curriculum (2, 3). Numerous studies have examined best practices for service-learning from varying stakeholder perspectives (faculty, student, and community partner) and disciplines, however, due to the recent development of public health as a major offering in U. Read More

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https://www.frontiersin.org/article/10.3389/fpubh.2019.00063
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http://dx.doi.org/10.3389/fpubh.2019.00063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454065PMC
April 2019
1 Read

Meeting the Educational Needs of Young, ME/CFS Patients: Role of the Treating Physician.

Authors:
Faith R Newton

Front Pediatr 2019 2;7:104. Epub 2019 Apr 2.

Department of Education, Delaware State University, Dover, DE, United States.

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https://www.frontiersin.org/article/10.3389/fped.2019.00104/
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http://dx.doi.org/10.3389/fped.2019.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455006PMC
April 2019
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Early identification of permanent maxillary canine impaction: A radiographic comparative study in a Mexican population.

J Clin Exp Dent 2019 Mar 1;11(3):e282-e286. Epub 2019 Mar 1.

DDS, MSc, PhD, Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosí, SLP, México.

Background: Opportune diagnosis, prediction, and interceptive treatment of permanent maxillary canine (PMC) impaction is fundamental for pediatric dentists and orthodontists. In children and young adolescents, diagnostic information obtained from a panoramic radiograph is valuable for the overview and prediction of a potential PMC ectopic eruption into the oral cavity. The aim of the present study was to calculate and compare the prevalence of impaction of PMC in a Mexican pediatric sample (7 to 13 years old), through the use of the Ericson & Kurol (EK/L) and the Power & Short (PS) measurement analyses performed on panoramic radiographs. Read More

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http://www.medicinaoral.com/medoralfree01/aop/55285.pdf
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http://dx.doi.org/10.4317/jced.55285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461733PMC
March 2019
1 Read

Infection in a C3HeB/FeJ Mouse Model.

Front Microbiol 2019 3;10:693. Epub 2019 Apr 3.

Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, United States.

Infections caused by complex (MAC) species are increasing worldwide, resulting in a serious public health problem. Patients with MAC lung disease face an arduous journey of a prolonged multidrug regimen that is often poorly tolerated and associated with relatively poor outcome. Identification of new animal models that demonstrate a similar pulmonary pathology as humans infected with MAC has the potential to significantly advance our understanding of nontuberculosis mycobacteria (NTM) pathogenesis as well as provide a tractable model for screening candidate compounds for therapy. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00693DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456659PMC

The Effect of Exenatide on Cardiovascular Risk Markers in Women With Polycystic Ovary Syndrome.

Front Endocrinol (Lausanne) 2019 2;10:189. Epub 2019 Apr 2.

Weill Cornell Medicine Qatar, Education City, Doha, Qatar.

Polycystic ovary syndrome (PCOS) is associated with an adverse cardiovascular risk profile including a prothrombotic state. Exenatide has been shown to be effective at improving insulin sensitivity and weight loss in PCOS; therefore this study was undertaken to assess its effects on weight, endothelial function, inflammatory markers, and fibrin structure/function in overweight/obese women with PCOS. Thirty overweight/obese anovulatory women with all 3 Rotterdam criteria received exenatide 5 mcg bd for 4 weeks then 10 mcg bd for 12 weeks. Read More

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http://dx.doi.org/10.3389/fendo.2019.00189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454834PMC

Cognitive Development Trajectories in Preterm Children With Very Low Birth Weight Longitudinally Followed Until 11 Years of Age.

Front Physiol 2019 2;10:307. Epub 2019 Apr 2.

Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

There is a high prevalence of cognitive dysfunction in very low birthweight (500-1250 g) infants (VLBW). Understanding long-term risk factors associated with cognitive development in preterm children requires longitudinal characterization. Thus, follow-up evaluations, including identification of risks and resilience influences-are important to promote health and cognitive abilities of children born preterm. Read More

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http://dx.doi.org/10.3389/fphys.2019.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454032PMC

Proposal of a new anatomical landmark to identify the disc space in endoscopic lumbar discectomy.

J Craniovertebr Junction Spine 2019 Jan-Mar;10(1):39-41

Department of Neurosurgery, International Neuroscience Institute, Hannover, Germany.

Introduction: In endoscopic lumbar discectomy for posterolateral disc herniation, we determined some anatomical landmarks for improved disc space access. These landmarks are based on the beginning of the insertion of the ligamentum flavum (LF) to vertebral lamina.

Materials And Methods: In 978 patients operated by posterolateral disc herniation, we measured prospectively the distance between the beginning of the insertion of the LF and space disc rostrally. Read More

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http://dx.doi.org/10.4103/jcvjs.JCVJS_103_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469320PMC

Identification of stressors and Perceptional difference of stress in first and final year Doctor of Physical Therapy students; a comparative study.

J Pak Med Assoc 2019 Apr;69(4):572-575

Bahria University Medical and Dental College, Karachi, Pakistan.

The aim of the study is to identify the main causes of stress and to identify the perception difference of stress in first and final year DPT students Students in universities can experience stress in balancing the different demands on them - academic, interpersonal, intrapersonal, and professional or work related. A comparative Cross-sectional study was conducted using self-administered questionnaires including socio demographics A total of 177 university students (first year 109 & final year 68 students) were included in the period March, to September 2015 in a private medical college Islamabad. Significantly valid tool (The Medical Student Stressor Questionnaire) (MSSQ) was used to measure the stress level. Read More

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Effect of simulation based education for learning in Medical Students: A mixed study method.

Authors:
Sajida Agha

J Pak Med Assoc 2019 Apr;69(4):545-554

King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

This mixed method study was planned to assess the medical students' experience with simulation-based learning and to identify the issues associated with the application of simulation-based education for experiential learning. Quantitative and qualitative data was collected respectively through a structured questionnaire answered by 145 undergraduate medical students and focus group interviews with six internees who experienced and practised clinical skills with simulators during academic years at King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, between March and April 2017. Although overall respondents were satisfied with simulation-based education, lower satisfaction was identified in areas of available facilities, allocated time for skill labs and debriefing sessions. Read More

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April 2019
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Clinical, immunophenotypic, and genomic findings of acute undifferentiated leukemia and comparison to acute myeloid leukemia with minimal differentiation: a study from the bone marrow pathology group.

Mod Pathol 2019 Apr 18. Epub 2019 Apr 18.

Department of Pathology and Laboratory Medicine, University of Chicago, Chicago, IL, USA.

Acute undifferentiated leukemia is a rare type of acute leukemia that shows no evidence of differentiation along any lineage. Clinical, immunophenotypic and genetic data is limited and it is uncertain if acute undifferentiated leukemia is biologically distinct from acute myeloid leukemia with minimal differentiation, which also shows limited myeloid marker expression and has been reported to have a poor prognosis. We identified 92 cases initially diagnosed as acute undifferentiated leukemia or acute myeloid leukemia with minimal differentiation from pathology databases of nine academic institutions with available diagnostic flow cytometric data, cytogenetic findings, mutational and clinical data. Read More

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http://dx.doi.org/10.1038/s41379-019-0263-3DOI Listing

A dataset of publication records for Nobel laureates.

Sci Data 2019 Apr 18;6(1):33. Epub 2019 Apr 18.

Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL, USA.

A central question in the science of science concerns how to develop a quantitative understanding of the evolution and impact of individual careers. Over the course of history, a relatively small fraction of individuals have made disproportionate, profound, and lasting impacts on science and society. Despite a long-standing interest in the careers of scientific elites across diverse disciplines, it remains difficult to collect large-scale career histories that could serve as training sets for systematic empirical and theoretical studies. Read More

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http://dx.doi.org/10.1038/s41597-019-0033-6DOI Listing

Adolescent and Young Adult Cancer Patients' Experiences With Treatment Decision-making.

Pediatrics 2019 Apr 18. Epub 2019 Apr 18.

Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts.

Background: Adolescents and young adults (AYAs) with cancer generally want to engage in decision-making but are not always able to do so. We evaluated cancer treatment decision-making among AYAs, including decisional engagement and regret.

Methods: We surveyed 203 AYA patients with cancer aged 15 to 29 (response rate 74%) treated at a large academic center and their oncologists. Read More

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http://dx.doi.org/10.1542/peds.2018-2800DOI Listing

Authors' response to Dr John Eggleton's letter.

BMJ Sex Reprod Health 2019 04;45(2):169

Women's Health Academic Centre, King's College London, London, UK.

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http://dx.doi.org/10.1136/bmjsrh-2018-200289DOI Listing
April 2019
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Should I publish in an open access journal?

BMJ 2019 Apr 18;365:l1544. Epub 2019 Apr 18.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, UK

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http://dx.doi.org/10.1136/bmj.l1544DOI Listing

Primary palliative care needs urgent attention.

BMJ 2019 Apr 18;365:l1827. Epub 2019 Apr 18.

Primary Palliative Care Research Group, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, UK.

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http://www.bmj.com/lookup/doi/10.1136/bmj.l1827
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http://dx.doi.org/10.1136/bmj.l1827DOI Listing
April 2019
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Describing the patient experience from Yelp reviews of community pharmacies.

J Am Pharm Assoc (2003) 2019 Apr 15. Epub 2019 Apr 15.

Objectives: To examine the characteristics of patient experience in community pharmacies through pattern exploration techniques of the unstructured free-text data from an online review website.

Design: Retrospective observational study design using structural topic model (STM) and term frequency-inverse document frequency (tf-idf) to categorize free-text data. Tf-idf scores words in terms of importance, and STM extracts latent themes from free-text data based on the co-occurrence of words in a review. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15443191193007
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http://dx.doi.org/10.1016/j.japh.2019.02.004DOI Listing
April 2019
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Clinical utility of genomic analysis in adults with idiopathic liver disease.

J Hepatol 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Electronic address:

Background & Aims: Adult patients suffering from liver disease of unknown cause represent an understudied and underserved population. The use of whole-exome sequencing (WES) for the assessment of a broader spectrum of non-oncological diseases, among adults, remains poorly studied. We assessed the utility of WES in the diagnosis and management of adults with unexplained liver disease despite comprehensive evaluation by a hepatologist and with no history of alcohol overuse. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193011
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http://dx.doi.org/10.1016/j.jhep.2019.01.036DOI Listing
April 2019
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Comparison of Ajmaline and Procainamide Provocation Tests in the Diagnosis of Brugada Syndrome.

JACC Clin Electrophysiol 2019 Apr 27;5(4):504-512. Epub 2019 Mar 27.

Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:

Objectives: The authors studied the response rates and relative sensitivity of the most common agents used in the sodium-channel blocker (SCB) challenge.

Background: A type 1 Brugada electrocardiographic pattern precipitated by an SCB challenge confers a diagnosis of Brugada syndrome.

Methods: Patients undergoing an SCB challenge were prospectively enrolled across Canada and the United Kingdom. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.01.026DOI Listing

Atrial Tachycardia Arising From the Crista Terminalis, Detailed Electrophysiological Features and Long-Term Ablation Outcomes.

JACC Clin Electrophysiol 2019 Apr 27;5(4):448-458. Epub 2019 Mar 27.

Department of Cardiology, Royal Melbourne Hospital, Melbourne, Australia; Faculty of Medicine, Dentistry, and Health Sciences, University of Melbourne, Parkville, Victoria, Australia. Electronic address:

Objectives: The goal of this study was to characterize, in detail, focal atrial tachycardia (AT) arising from the crista terminalis to investigate associations with other atrial arrhythmia and to define long-term ablation outcomes.

Background: The crista terminalis is known to be the most common site of origin for focal AT, but it is not well characterized.

Methods: This study retrospectively identified a total of 548 ablation procedures for AT performed at a single center over a 16-year period, of which 171 were arising from the crista terminalis. Read More

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http://dx.doi.org/10.1016/j.jacep.2019.01.014DOI Listing

Contemporary Outcomes Following Coronary Artery Bypass Graft Surgery for Left Main Disease.

J Am Coll Cardiol 2019 Apr;73(15):1877-1886

Department of Cardiology, Imperial College of London, London, United Kingdom. Electronic address:

Background: Although results of percutaneous coronary intervention (PCI) have been steadily improving, whether surgical outcomes have improved over time is not fully elucidated.

Objectives: This study sought to compare the current outcomes of patients undergoing coronary artery bypass grafting (CABG) with prior surgical results, in the context of randomized trials including the left main (LM) coronary artery stem.

Methods: The authors performed a propensity-matched analysis of patients randomized to CABG in the SYNTAX (Synergy Between PCI With Taxus and Cardiac Surgery) (enrollment period 2005 to 2007) and EXCEL (Evaluation of XIENCE Versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization) (enrollment period 2010 to 2014) trials. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07351097193369
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http://dx.doi.org/10.1016/j.jacc.2018.12.090DOI Listing
April 2019
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Two novel mutations in exon 3 of PHOX2B gene: think about congenital central hypoventilation syndrome in patients with Hirschsprung disease.

Ital J Pediatr 2019 Apr 18;45(1):49. Epub 2019 Apr 18.

Respiratory Unit, Academic Department of Pediatrics, Bambino Gesù Children's Hospital, IRCCS, Piazza di Sant'Onofrio 4, 00165, Rome, Italy.

Background: Congenital central hypoventilation syndrome (CCHS) is characterized by alveolar hypoventilation increasing during sleep and affected patients are unable to perceive and respond to hypercarbia with increased ventilation and arousal during sleep. PHOX2B gene mutations are considered as responsible for CCHS. Most of patients with CCHS are heterozygous for polyalanine expansion mutations (PARMs) in exon 3, but 10% of patients with classic CCHS are heterozygous for non-polyalanine expansion mutations (NPARMs) of the PHOX2B gene. Read More

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http://dx.doi.org/10.1186/s13052-019-0636-8DOI Listing

Student motivation to learn: is self-belief the key to transition and first year performance in an undergraduate health professions program?

BMC Med Educ 2019 Apr 18;19(1):111. Epub 2019 Apr 18.

Faculty of Health and Medical Sciences, The University of Western Australia, 35 Stirling Hwy, Nedlands, Western Australia, 6009, Australia.

Background: Student motivation to learn has been undervalued to date though has been identified as an area influencing student success and retention at university. The transition into university has been highlighted as a key period affecting student outcomes as well as well-being. Early identification of those students at risk may assist the transition for many students moving into higher education. Read More

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https://bmcmededuc.biomedcentral.com/articles/10.1186/s12909
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http://dx.doi.org/10.1186/s12909-019-1539-5DOI Listing
April 2019
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