237,621 results match your criteria Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry[Journal]


Mouthguard use and TMJ injury prevention with different occlusions: A three-dimensional finite element analysis.

Dent Traumatol 2020 May 27. Epub 2020 May 27.

Department of Oral Cell Biology and Functional Anatomy, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU UniversityAmsterdam, Amsterdam, The Netherlands.

Background/aims: There is a lack of data regarding the temporomandibular joint's mechanical response during an impact to the orofacial region. The aim of this study was to analyze the biomechanical effects of wearing a mouthguard (MG) on the impact response of the mandibular condyle and articular disc according to the type of occlusion. The hypothesis was that the MG would minimize the effect in those structures, regardless of the occlusion type. Read More

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http://dx.doi.org/10.1111/edt.12577DOI Listing

Respiratory rate is an early predictor of clinical deterioration in children.

Pediatr Pulmonol 2020 May 27. Epub 2020 May 27.

Department of Respiratory Medicine, Academic Unit of Child Health, Sheffield Children's Hospital NHS Foundation Trust, Western Bank, Sheffield, UK.

Objective: To assess the value of respiratory rate (RR) as a predictor of clinical deterioration in children, compared with other vital sign measurements.

Design: A retrospective case-control study, comparing children who deteriorated, requiring admission to critical care with children who did not deteriorate.

Methods: RR, heart rate (HR), and blood pressure (BP) measurements were collected from each patient for a 48-hour duration. Read More

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http://dx.doi.org/10.1002/ppul.24853DOI Listing

Abstracts presented at the European Association for Osseointegration (EAO) Congresses: Publication fate and discrepancies with full-length articles.

Clin Oral Implants Res 2020 May 27. Epub 2020 May 27.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Wuhan, China.

Objectives: To investigate the full publication proportion (FPP) of abstracts presented at the 2010 and 2011 EAO Congresses, analyse the discrepancies between abstracts and their full publications, and explore potential predictors of FPP and discrepancies.

Methods: Abstracts presented at the 2010 and 2011 EAO Congresses were retrieved. Associated full publications were identified by searching PubMed, Embase and Google Scholar. Read More

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http://dx.doi.org/10.1111/clr.13620DOI Listing

Surgical Resection is Justifiable for Oral T4b Squamous Cell Cancers With Masticator Space Invasion.

Laryngoscope 2020 May 27. Epub 2020 May 27.

Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, Georgia, U.S.A.

Objectives: To examine survival endpoints in patients with tumor (T)4b oral cavity squamous cell carcinoma (OCSCC) with pathologically proven masticator space invasion treated with primary surgery followed by adjuvant therapy.

Study Design: Retrospective review at an academic cancer center.

Methods: Twenty-five patients with T4b OCSCC with pathologic masticator space invasion were treated with primary surgery from May 2012 to December 2016. Read More

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http://dx.doi.org/10.1002/lary.28725DOI Listing

Further evidence that chilblains are a cutaneous manifestation of COVID-19 infection.

Br J Dermatol 2020 May 27. Epub 2020 May 27.

Independent Vascular Services Ltd, The Vascular Studies Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Southmoor Road, Manchester, UK.

A range of cutaneous conditions including chilblain-like lesions have been reported in patients with Coronavirus 2019 (COVID-19) due to severe acute respiratory Syndrome coronavirus 2 (SARS-Cov-2). Using clinical data and images, the authors of a recent nationwide Spanish survey identified 5 clinical patterns which were associated with different patient demographics, onset (timing), and prognosis. Read More

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http://dx.doi.org/10.1111/bjd.19243DOI Listing

Comparison of GaAs nanowire growth seeded by Ag and Au colloidal nanoparticles on silicon.

Nanotechnology 2020 May 27. Epub 2020 May 27.

St.Petersburg Academic University, St.Petersburg, RUSSIAN FEDERATION.

We present a comparative study of GaAs nanowire growth on Si(111) substrates by molecular beam epitaxy with the assist of Au and Ag colloidal nanoparticles. Our approach allows the synthesis of nanowires with different catalyst materials in separate sectors of the same substrate within the same epitaxial process. We match the experimental results to the modeling of chemical potentials and nanowire length distributions to analyze the impact of silicon atom incorporation to the catalyst droplets on the growth rates and size homogeneity in ensembles of Au and Ag-catalyzed GaAs nanowires. Read More

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http://dx.doi.org/10.1088/1361-6528/ab96e1DOI Listing

Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study.

EBioMedicine 2020 May 24;56:102807. Epub 2020 May 24.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, Mainz 55131, Germany. Electronic address:

Background: We aim to evaluate serum neurofilament light chain (sNfL), indicating neuroaxonal damage, as a biomarker at diagnosis in a large cohort of early multiple sclerosis (MS) patients.

Methods: In a multicentre prospective longitudinal observational cohort, patients with newly diagnosed relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) were recruited between August 2010 and November 2015 in 22 centers. Clinical parameters, MRI, and sNfL levels (measured by single molecule array) were assessed at baseline and up to four-year follow-up. Read More

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http://dx.doi.org/10.1016/j.ebiom.2020.102807DOI Listing

Performance of screening MRI in high risk patients at initial versus subsequent screen.

Clin Imaging 2020 May 16;66:87-92. Epub 2020 May 16.

Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Electronic address:

Purpose: To compare the characteristics, outcomes, and performance metrics in women undergoing initial breast MRI screening versus subsequent screening.

Methods: A retrospective database search identified screening MRIs performed at an academic practice from 2013 to 2015. MRIs were divided into two groups: (1) initial screens and (2) subsequent screens (interpreted with at least one prior MRI for comparison). Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.012DOI Listing

Hepatocyte-like cells derived from induced pluripotent stem cells: A versatile tool to understand lipid disorders.

Atherosclerosis 2020 Mar 21;303:8-14. Epub 2020 Mar 21.

Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands; Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands. Electronic address:

Dyslipidemias are strongly linked to the development of atherosclerotic cardiovascular disease. Most dyslipidemias find their origin in the liver. In recent years, the differentiation of induced pluripotent stem cells (iPSCs) into hepatocyte-like cells has provided a versatile platform for the functional study of various dyslipidemias, both rare genetic dyslipidemia as well as common lipid disorders associated with insulin resistance or non-alcoholic fatty liver disease. Read More

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http://dx.doi.org/10.1016/j.atherosclerosis.2020.03.014DOI Listing

E-waste lead exposure and children's health in China.

Sci Total Environ 2020 May 11;734:139286. Epub 2020 May 11.

School of Public Health, Xinxiang Medical University, 601 Jinsui Road, Xinxiang 453003, Henan, China.

China is one of the countries worldwide confronted with serious e-waste pollution and associated detrimental health effects, which has aroused public, academic and governmental concerns. Most local residents are exposed to hazardous substances such as lead (Pb) and other persistent organic pollutants because of informal e-waste recycling activities. This study reviews recent studies on children exposed to e-waste Pb in China focusing on health-related effects in children (e. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.139286DOI Listing

Teleneurology during the COVID-19 pandemic: A step forward in modernizing medical care.

J Neurol Sci 2020 May 21;414:116930. Epub 2020 May 21.

Beth Israel Deaconess Medical Center, Department of Neurology, 330 Brookline Ave, Boston 02215, MA, USA.

Background: The COVID-19 pandemic mandated rapid transition from face-to-face encounters to teleneurology visits. While teleneurology is regularly used in acute stroke care, its application in other branches of neurology was limited. Here we review how the recent pandemic has created a paradigm shift in caring for patients with chronic neurological disorders and how academic institutions have responded to the present need. Read More

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http://dx.doi.org/10.1016/j.jns.2020.116930DOI Listing

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease.

Cell Stem Cell 2020 May 20. Epub 2020 May 20.

Department of Anatomy and Embryology, Leiden University Medical Center, 2333 Leiden, the Netherlands; Department of Applied Stem Cell Technologies, University of Twente, 7500 Enschede, the Netherlands. Electronic address:

Cardiomyocytes (CMs) from human induced pluripotent stem cells (hiPSCs) are functionally immature, but this is improved by incorporation into engineered tissues or forced contraction. Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional microtissues (MTs). hiPSC-CMs in MTs with CFs showed improved sarcomeric structures with T-tubules, enhanced contractility, and mitochondrial respiration and were electrophysiologically more mature than MTs without CFs. Read More

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http://dx.doi.org/10.1016/j.stem.2020.05.004DOI Listing

Influence of Periodontal Maintenance and Periodontitis Susceptibility on Implant Success: A 5-year Retrospective Cohort on Moderately Rough Surfaced Implants.

Clin Oral Implants Res 2020 May 27. Epub 2020 May 27.

Restorative Dentistry, National Dental Centre, Singapore, Singapore.

Objectives: To investigate the effect of defined versus undefined periodontal maintenance after implant therapy on the prevalence of peri-implant complications.

Material And Methods: Two hundred patients who underwent dental implant therapy in the National Dental Centre Singapore (NDCS) from 2005 to 2012 were recruited. One hundred patients had regular periodontal maintenance (defined maintenance programme group, DMP) and the other 100 patients had no documentation of periodontal maintenance (undefined maintenance programme group, UMP). Read More

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http://dx.doi.org/10.1111/clr.13621DOI Listing

Breast Implant Imaging Surveillance among U.S. Plastic Surgeons: U.S. Food and Drug Administration Recommendations versus Clinical Reality.

Plast Reconstr Surg 2020 Jun;145(6):1381-1387

Hershey, Pa.; and Houston, Texas From the Department of Surgery, Division of Plastic Surgery, Pennsylvania State University, College of Medicine; and the Departments of Plastic Surgery and Diagnostic Radiology, M. D. Anderson Cancer Center, University of Texas.

Background: Device rupture is considered a major complication associated with breast implants. The U.S. Read More

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http://dx.doi.org/10.1097/PRS.0000000000006812DOI Listing

Insights from COVID-Related Accommodation Requests (Alternate Work Assignments) by Clinical Staff at an Academic Medical Center.

J Occup Environ Med 2020 May 26. Epub 2020 May 26.

North America Medical Leader, The Procter and Gamble Company, Assistant Professor of Medicine, Department of Medicine, Johns Hopkins School of Medicine Professor of Population Health, Dell Medical School, University of Texas at Austin, Professor of Medicine, Department of Medicine, Johns Hopkins University School of Medicine Assistant Scientist, Department of Health Policy and Management, Bloomberg School of Public Health, Johns Hopkins University Associate Director, Occupational Health Services, School of Medicine, Johns Hopkins University Assistant Director, Insurance and Information Technology, School of Medicine, Johns Hopkins University Associate Professor and Research Director, Division of Occupational and Environmental Medicine, Department of Medicine, Johns Hopkins University School of Medicine.

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http://dx.doi.org/10.1097/JOM.0000000000001925DOI Listing

Disparities in Burnout and Satisfaction With Work-Life Integration in U.S. Physicians By Gender and Practice Setting.

Acad Med 2020 May 26. Epub 2020 May 26.

A.L. Marshall is associate professor of medicine, Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota; ORCID: http://orcid.org/0000-0001-7388-0422. L.N. Dyrbye is professor of medicine and medical education, Division of Community Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota. T.D. Shanafelt is Jeanie and Stewart Ritchie Professor of Medicine and associate dean, Stanford School of Medicine, Stanford, California. C.A. Sinsky is vice president of professional satisfaction, American Medical Association, Chicago, Illinois. D. Satele is a statistician, Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. M. Trockel is clinical associate professor, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California. M. Tutty is group vice president of professional satisfaction and practice sustainability, American Medical Association, Chicago, Illinois. C.P. West is professor of medicine, medical education, and biostatistics, Division of General Internal Medicine, Department of Internal Medicine, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; ORCID: https://orcid.org/0000-0003-1628-5023.

Purpose: To explore the interaction between practice setting (academic practice [AP], private practice [PP]) and gender in relation to physician burnout and satisfaction with work-life integration (WLI).

Method: In 2017, the authors administered a cross-sectional survey of U.S. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003521DOI Listing

Proposed Changes to the 2021 Residency Application Process in the Wake of COVID-19.

Acad Med 2020 May 26. Epub 2020 May 26.

A.T. Gabrielson is a urology resident, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. J.R. Kohn is a gynecology and obstetrics resident, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland. H.T. Sparks is a pediatrics resident, Department of Pediatrics, Children's National Hospital, Washington, DC. M.M. Clifton is assistant professor, female pelvic medicine and reconstructive surgery, and director, urology residency program, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland. T.P. Kohn is a urology resident, The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland.

The COVID-19 pandemic has brought unique challenges to the delivery of undergraduate medical education, particularly for current third-year medical students who are preparing to apply to residency. In mid-March, medical schools suspended all clinical rotations for the remainder of the 2019-2020 academic year. As such, third-year medical students may not be able to complete sufficient clinical experiences to make important career choices before they have to submit their residency applications. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003520DOI Listing

Routine Venous Thromboembolism Prophylaxis May Be Inadequate in the Hypercoagulable State of Severe Coronavirus Disease 2019.

Crit Care Med 2020 May 27. Epub 2020 May 27.

Department of Surgery, Indiana University School of Medicine, Indianapolis, IN.

Objectives: The aim of this study was to determine the frequency of venous thromboembolism in critically ill coronavirus disease 2019 patients and associate a degree of inflammatory marker elevation to venous thromboembolism development.

Design: An observational study that identified patients with severe coronavirus disease 2019 between March 12, 2020, and March 31, 2020. Data reported are those available through May 6, 2020. Read More

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http://dx.doi.org/10.1097/CCM.0000000000004466DOI Listing

Mobile Personal Healthcare System for Non-Invasive, Pervasive and Continuous Blood Pressure Monitoring: A Feasibility Study.

JMIR Mhealth Uhealth 2020 Apr 26. Epub 2020 Apr 26.

Departments of Neurosciences and Human Genetics, and Rio Grande Valley Alzheimer´s Disease Resource Center for Minority Aging Research, University of Texas Rio Grande Valley, Brownsville, US.

Background: Smartphone-based blood pressure (BP) monitor using photoplethysmogram (PPG) technology has emerged as a promising approach to empower users with self-monitoring for effective diagnosis and control of hypertension (HT).

Objective: This study aimed to develop a mobile personal healthcare system for non-invasive, pervasive, and continuous estimation of BP level and variability to be user-friendly to elderly.

Methods: The proposed approach was integrated by a self-designed cuffless, calibration-free, wireless and wearable PPG-only sensor, and a native purposely-designed smartphone application using multilayer perceptron machine learning techniques from raw signals. Read More

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http://dx.doi.org/10.2196/18012DOI Listing

Health Equity in the Effectiveness of Web-Based Health Interventions for the Self-Care of People With Chronic Health Conditions: Systematic Review.

J Med Internet Res 2020 Mar 29. Epub 2020 Mar 29.

School for Policy Studies, University of Bristol, Bristol, GB.

Background: Web-based self-care interventions have the potential to reduce health inequalities by removing barriers to access to health care. However, there is a lack of evidence about the equalizing effects of these interventions on chronic conditions.

Objective: This study investigated the differences in the effectiveness of web-based behavioral change interventions for the self-care of high burden chronic health conditions (eg, asthma, chronic obstructive pulmonary disease [COPD], diabetes, and osteoarthritis) across socioeconomic and cultural groups. Read More

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http://dx.doi.org/10.2196/17849DOI Listing

Multiple Myeloma Cost of Care Under the Oncology Care Model: The Influence of High-Cost Therapies.

JCO Oncol Pract 2020 May 27:JOP1900569. Epub 2020 May 27.

Tisch Cancer Institute, Division of Hematology/Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY.

Purpose: As expenditures for cancer care continue to grow substantially, value-based payment models are being tested to control costs. The Oncology Care Model (OCM) is the largest value-based payment program in oncology. The primary objective of this analysis was to determine the impact of high-cost novel agents on total cost of care for multiple myeloma (MM) episodes of care in the OCM. Read More

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http://dx.doi.org/10.1200/JOP.19.00569DOI Listing

Developing Pathology Measures for the Quality Payment Program-Part II: Overcoming Challenges With Data Capture to Maximize Reimbursement.

Arch Pathol Lab Med 2020 Jun;144(6):697-705

From the Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston (Dr Kelley); the Department of Pathology, Warren Alpert Medical School of Brown University, Lifespan Academic Medical Center, Providence, Rhode Island (Dr Patil); the Advocacy Division, College of American Pathologists, Washington, DC (Mss Kennedy, Singh, and Peditto); and the Department of Pathology, Duke University Medical Center, Durham, North Carolina (Dr Cardona). Ms Kennedy is currently with the American Society of Clinical Oncology, Arlington, Virginia.

Context.—: Quality measures are a cornerstone in measuring physicians' performance within the Centers for Medicare & Medicaid Services' Quality Payment Program (QPP). Clinicians' performance on quality measures and other categories within the QPP determines Medicare part B payment adjustments. Read More

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http://dx.doi.org/10.5858/arpa.2019-0378-OADOI Listing

Executive Summary of the Early-Onset Breast Cancer Evidence Review Conference.

Obstet Gynecol 2020 Jun;135(6):1457-1478

Department of Obstetrics and Gynecology, Virginia Commonwealth University School of Medicine, Richmond, Virginia; the Department of Obstetrics and Gynecology, University of Michigan Medical School, Ann Arbor, Michigan; the Department of Women's Health, the University of Texas at Austin Dell Medical School, Austin, Texas; the Departments of Obstetrics and Gynecology and Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin; the Department of Obstetrics and Gynecology, Thomas Jefferson University Hospital, Sidney Kimmel Medical College, Philadelphia, Pennsylvania; Southeast Kaiser Permanente Medical Group, Atlanta, Georgia; the Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington; the Department of Obstetrics and Gynecology, University of Connecticut Medical School, Farmington, Connecticut; and the American College of Obstetricians and Gynecologists, Washington, DC.

The Centers for Disease Control and Prevention launched the Bring Your Brave campaign to increase knowledge about early-onset breast cancer, defined as breast cancer in women aged 18-45 years. The American College of Obstetricians and Gynecologists convened a panel of experts in breast disease from the Society for Academic Specialists in General Obstetrics and Gynecology to review relevant literature, validated tools, best practices, and practice guidelines as a first step toward developing educational materials for women's health care providers about early-onset breast cancer. Panel members conducted structured literature reviews, which were then reviewed by other panel members and discussed at an in-person meeting of stakeholder professional and patient advocacy organizations in April 2019. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003889DOI Listing

Vanishing Twins Conceived Through Fresh In Vitro Fertilization: Obstetric Outcomes and Placental Pathology.

Obstet Gynecol 2020 Jun;135(6):1426-1433

Massachusetts General Hospital Fertility Center and Harvard Medical School, Boston, Massachusetts; the Department of Women's Health, Wright Patterson Air Force Base, Wright Patterson AFB, and the Department of Obstetrics & Gynecology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio; the Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; CellNetix Pathology and Laboratories and Swedish Medical Center, Seattle, Washington; and the Deborah Kelly Center for Outcomes Research, the Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, and the Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, Reproductive Endocrinology/Infertility, Department of Obstetrics & Gynecology, UMass Memorial Medical Center, Worcester, Boston IVF, Waltham, and the Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Objective: To characterize the obstetric outcomes and placental pathology in live births arising from vanishing twin pregnancies compared with nonreduced in vitro fertilization (IVF) pregnancies.

Methods: This is a retrospective cohort study of live births resulting from fresh embryo transfers after IVF cycles with autologous oocytes from 2004 through 2017 at a large academic fertility center. Clinical information and pathology reports were reviewed. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003888DOI Listing

Telehealth Utilization in Response to the Novel Coronavirus (COVID-19) Pandemic in Orthopaedic Surgery.

J Am Acad Orthop Surg 2020 Jun;28(11):e487-e492

From the University of Pennsylvania (Dr. Parisien), Perelman School of Medicine at the University of Pennsylvania (Mr. Shin), College of Physicians and Surgeons at Columbia University (Mr. Constant), OrthoCarolina (Dr. Saltzman), Boston University Medical Center (Dr. Li), and Columbia University Medical Center (Dr. Levine and Dr. Trofa).

Introduction: The purpose of this investigation is to assess the current utilization of telehealth capabilities at academic orthopaedic departments in the United States and to determine how practice patterns have been directly influenced by the coronavirus disease 19 (COVID-19) pandemic.

Methods: Orthopaedic surgery programs participating in the Electronic Residency Application Service were identified. One hundred seventy-five (175) programs were presented with a seven-item questionnaire addressing whether each program is using telehealth services in response to the COVID-19 pandemic. Read More

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http://dx.doi.org/10.5435/JAAOS-D-20-00339DOI Listing

Four-Year Experience of Digital Slide Telepathology for Intraoperative Frozen Section Consultations in a Two-Site French Academic Department of Pathology.

Am J Clin Pathol 2020 May 27. Epub 2020 May 27.

Department of Pathology, AP-HP-Université Paris Saclay, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Objectives: To share our experience with digital slide telepathology for intraoperative frozen section consultations (IOCs) and to describe its evolution over time by reporting performance metrics and addressing organizational and economic aspects.

Methods: Since 2013, a technician has been alone at the surgical site. At the other site, the pathologist opens the digital slide from a local server via the intranet. Read More

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http://dx.doi.org/10.1093/ajcp/aqaa055DOI Listing

How Geographical Isolation and Aging in Place Can Be Accommodated Through Connected Health Stakeholder Management: Qualitative Study With Focus Groups.

J Med Internet Res 2020 May 27;22(5):e15976. Epub 2020 May 27.

Nanjing Audit University, Naijing, China.

Background: In remote areas, connected health (CH) is needed, but as local resources are often scarce and the purchasing power of residents is usually poor, it is a challenge to apply CH in these settings. In this study, CH is defended as a technological solution for reshaping the direction of health care to be more proactive, preventive, and precisely targeted-and thus, more effective.

Objective: The objective of this study was to explore the identity of CH stakeholders in remote areas of Taiwan and their interests and power in order to determine ideal strategies for applying CH. Read More

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http://dx.doi.org/10.2196/15976DOI Listing

Improving Quality of Care in Rheumatoid Arthritis Through Mobile Patient-Reported Outcome Measurement: Focus Group Study.

JMIR Form Res 2020 May 27;4(3):e15158. Epub 2020 May 27.

Division of Rheumatology, Brigham & Women's Hospital, Boston, MA, United States.

Background: Patient-reported outcomes (PROs) for chronic disease management can be integrated into the routine workflow by leveraging mobile technology.

Objective: The objective of our study was to describe the process of our quality improvement (QI) efforts using tablets for PRO collection in a busy, academic rheumatology practice to support a treat-to-target (TTT) approach for rheumatoid arthritis (RA) management.

Methods: Our QI team designed a process for routine collection of PROs for RA patients at the Arthritis Center, employing information technology and an electronic medical record (EMR) system. Read More

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http://dx.doi.org/10.2196/15158DOI Listing

Efficiency of chemical versus mechanical disruption methods of DNA extraction for the identification of oral Gram-positive and Gram-negative bacteria.

J Int Med Res 2020 May;48(5):300060520925594

Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Objective: Clinical diagnostics often requires the detection of multiple bacterial species in limited clinical samples with a single DNA extraction method. This study aimed to compare the bacterial DNA extraction efficiency of two lysis methods automated with the MagNA-Pure LC instrument. The samples included five oral bacterial species (three Gram-positive and two Gram-negative) with or without human saliva background. Read More

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http://dx.doi.org/10.1177/0300060520925594DOI Listing

Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry.

Endoscopy 2020 May 26. Epub 2020 May 26.

University College London Hospitals NHS Foundation Trust, Gastroenterology, London, United Kingdom of Great Britain and Northern Ireland.

Introduction Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and associated with a 2-17% mortality in the United Kingdom (UK) and USA [1]. Peptic ulcers account for 50% of UGIB's. Endoscopic intervention in a timely manner can improve outcomes. Read More

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http://dx.doi.org/10.1055/a-1186-5360DOI Listing

COVID-19 pandemic - An African perspective.

Emerg Microbes Infect 2020 May 27:1-28. Epub 2020 May 27.

Clinical Microbiology and Infectious Diseases, School of Pathology, Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.

The recently emerged novel coronavirus, "severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)", caused a highly contagious disease called coronavirus disease 2019 (COVID-19). The virus was first reported from Wuhan city in China in December, 2019, which in less than three months spread throughout the globe and was declared a global pandemic by the World Health Organization (WHO) on 11 of March, 2020. So far, the ongoing pandemic severely damaged the world's most developed countries and is becoming a major threat for low- and middle-income countries. Read More

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http://dx.doi.org/10.1080/22221751.2020.1775132DOI Listing

HighVia-A Flexible Live-Cell High-Content Screening Pipeline to Assess Cellular Toxicity.

SLAS Discov 2020 May 27:2472555220923979. Epub 2020 May 27.

Nuffield Department of Clinical Medicine, Target Discovery Institute, University of Oxford, Oxford, UK.

High-content screening to monitor disease-modifying phenotypes upon small-molecule addition has become an essential component of many drug and target discovery platforms. One of the most common phenotypic approaches, especially in the field of oncology research, is the assessment of cell viability. However, frequently used viability readouts employing metabolic proxy assays based on homogeneous colorimetric/fluorescent reagents are one-dimensional, provide limited information, and can in many cases yield conflicting or difficult-to-interpret results, leading to misinterpretation of data and wasted resources. Read More

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http://dx.doi.org/10.1177/2472555220923979DOI Listing

Applying the Theory of Gendered Organizations to the Lived Experience of Women with Established Careers in Academic Medicine.

Teach Learn Med 2020 May 27:1-10. Epub 2020 May 27.

Departments of Medical Education and Sociology, University of Illinois-Chicago, Chicago, USA.

The number of women who enter medical school has been on par with the number of men for almost 20 years, but parity in training has not translated to equity in professional life. To capitalize on the perspective of women faculty with established careers in academic medicine and to bring theory to the largely descriptive research on gender inequity in academic medicine, the authors used the Theory of Gendered Organizations to demonstrate how academic medical centers function as inherently gendered organizations. The authors recruited women faculty with established careers at one academic medical center based on purposeful and snowball sampling and interviewed 30 participants in Summer/Fall 2018. Read More

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http://dx.doi.org/10.1080/10401334.2020.1767106DOI Listing

Radiotranscriptomics signature-based predictive nomograms for radiotherapy response in patients with nonsmall cell lung cancer: Combination and association of CT features and serum miRNAs levels.

Cancer Med 2020 May 27. Epub 2020 May 27.

Department of Radiation Oncology, Shandong First Medical University and Shandong Academy of Medical Sciences, Shandong Cancer Hospital and Institute, Huaiyin Region, Jinan, Shandong, China.

Purpose: We aimed to establish radiotranscriptomics signatures based on serum miRNA levels and computed tomography (CT) texture features and develop nomogram models for predicting radiotherapy response in patients with nonsmall cell lung cancer (NSCLC).

Methods: We first used established radioresistant NSCLC cell lines for miRNA selection. At the same time, patients (103 for training set and 71 for validation set) with NSCLC were enrolled. Read More

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http://dx.doi.org/10.1002/cam4.3115DOI Listing

Restructuring an Academic Dermatology Practice During the COVID-19 Pandemic.

Dermatol Ther 2020 May 27. Epub 2020 May 27.

Department of Dermatology, St George Hospital, Wales.

SARS-COV-2 is a highly virulent positive-sense single stranded RNA virus that spreads rapidly via respiratory droplets, causing severe acute respiratory syndromes with significant mortality and morbidity. Currently 210 countries and territories are affected around the world with a reported 2.6 million confirmed cases. Read More

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http://dx.doi.org/10.1111/dth.13684DOI Listing

Immunosuppressive and immunomodulator therapy for rare or uncommon skin disorders in pandemic days.

Dermatol Ther 2020 May 27:e13686. Epub 2020 May 27.

Department of Dermatology and Allergology, Städtisches Klinikum Dresden, Academic Teaching Hospital, Dresden, Germany.

Immunosuppressive and immunomodulatory therapies are important in dermatology, but indications are influenced by SARS-CoV-2. We will focus on are skin disorders such as autoimmune connective tissue disorders, neutrophilic dermatoses and vasculitis. Immunomodulators such as colchicine and antimalarials can easily be preferred taking their beneficial effects on Covid-19 into consideration and also given their wide spectrum of action. Read More

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http://dx.doi.org/10.1111/dth.13686DOI Listing

Biological sensitivity to context in Pakistani preschoolers: Hair cortisol and family wealth are interactively associated with girls' cognitive skills.

Dev Psychobiol 2020 May 26. Epub 2020 May 26.

Stanford University, Stanford, CA, USA.

Many young children in low- and middle-income countries (LMICs) face heightened risk for experiencing environmental adversity, which is linked with poorer developmental outcomes. Children's stress physiology can shed light on why children are differentially susceptible to adversity. However, no known studies have examined whether links between adversity and children's development are moderated by children's stress physiology in LMICs. Read More

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http://dx.doi.org/10.1002/dev.21981DOI Listing

Comparison of Measured Energy Expenditure Using Indirect Calorimetry Versus Predictive Equations for Liver Transplant Recipients.

JPEN J Parenter Enteral Nutr 2020 May 26. Epub 2020 May 26.

Division of Acute Care Surgery, Department of Surgery, Ulsan University College of Medicine, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, South Korea.

Background: To assess the appropriate energy expenditure requirement for liver transplant (LT) recipients in South Korea, four commonly used predictive equations were compared with indirect calorimetry.

Methods: A prospective observational study was conducted in the surgical ICU of an academic tertiary hospital between December 2017 and September 2018. The study population comprised LT recipients expected to remain in the ICU > 48 hours postoperatively. Read More

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http://dx.doi.org/10.1002/jpen.1932DOI Listing

A Structured Approach for Safely Reintroducing Bariatric Surgery in a COVID-19 Environment.

Obes Surg 2020 May 26. Epub 2020 May 26.

Bariatric and Metabolic Institute, Department of General Surgery, Cleveland Clinic, 9500 Euclid Avenue, Desk M61, Cleveland, OH, 44195, USA.

Due to the profound effect of novel coronavirus disease 2019 (COVID-19) on healthcare systems, surgical programs across the country have paused surgical operations and have been utilizing virtual visits to help maintain public safety. For those who treat obesity, the importance of bariatric surgery has never been more clear. Emerging studies continue to identify obesity and several other obesity-related comorbid conditions as major risk factors for a more severe COVID-19 disease course. Read More

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http://dx.doi.org/10.1007/s11695-020-04733-8DOI Listing

Representation on the Editorial Boards of Academic Psychiatry Journals: the Gender Difference.

Acad Psychiatry 2020 May 26. Epub 2020 May 26.

Henry Ford Health System, Detroit, MI, USA.

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http://dx.doi.org/10.1007/s40596-020-01249-2DOI Listing

The importance of discovery science in the development of therapies for the critically ill.

Intensive Care Med Exp 2020 May 26;8(1):17. Epub 2020 May 26.

Anaesthesia, School of Medicine, National University of Ireland, Galway, Ireland.

Discovery science, a term which encompasses basic, translational, and computational science with the aim to discover new therapies, has advanced critical care. By combining knowledge on inflammatory and genomic pathways with computational methods, discovery science is currently enabling us to optimize clinical trials design by predictive enrichment and to move into the era of personalized medicine for complex syndromes such as sepsis and ARDS. Whereas computational methods are gaining in interest, efforts to invest in basic and translational science in critical care are declining. Read More

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http://dx.doi.org/10.1186/s40635-020-00304-4DOI Listing

Predatory Publishers/Journals in Medical Sciences: How to Avoid, Stop, and What to Do after Being Scammed by Them?

J Gastrointest Cancer 2020 May 27. Epub 2020 May 27.

Department of Histopathology and Cytology, Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan.

Purpose: The phenomenon of predatory publishers and journals is one of the recent issues to affect the scientific field. It has negative impacts upon scientific research and harmful consequences, including the spread of pseudo-medical sciences. This article discusses general outlines regarding the concept of predatory journals to clarify this issue for junior researchers and academic workers. Read More

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http://dx.doi.org/10.1007/s12029-020-00418-8DOI Listing

Acute transverse myelitis after COVID-19 pneumonia.

J Neurol 2020 May 26. Epub 2020 May 26.

Department of Neurology and Clinical Neurophysiology, Medical Center Esslingen, Academic Teaching Hospital of the University of Tübingen, Hirschschlandstr. 97, 73730, Esslingen, Germany.

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http://dx.doi.org/10.1007/s00415-020-09934-wDOI Listing

Non-epileptic seizures in autonomic dysfunction as the initial symptom of COVID-19.

J Neurol 2020 May 26. Epub 2020 May 26.

Department of Neurology and Neurorehabilitation, Hospital Zum Heiligen Geist, Academic Teaching Hospital of the Heinrich-Heine-University Düsseldorf, von-Broichhausen-Allee 1, 47906, Kempen, Germany.

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http://dx.doi.org/10.1007/s00415-020-09904-2DOI Listing

The Effect of Statins through Mast Cells in the Pathophysiology of Atherosclerosis: a Review.

Curr Atheroscler Rep 2020 May 26;22(5):19. Epub 2020 May 26.

Halal Research Center of IRI, FDA, Tehran, Iran.

Purpose Of Review: In this review, we discuss the evidence supporting the effects of statins on mast cells (MCs) in atherosclerosis and their molecular mechanism of action.

Recent Findings: Statins or HMG-CoA reductase inhibitors are known for their lipid-lowering properties and are widely used in the prevention and treatment of cardiovascular diseases. There is growing evidence that statins have an inhibitory effect on MCs, which contributes to the pleiotropic effect of statins in various diseases. Read More

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http://dx.doi.org/10.1007/s11883-020-00837-9DOI Listing

The work and training situation for young physicians undergoing specialty training in gynecology and obstetrics in Germany: an assessment of the status quo.

Arch Gynecol Obstet 2020 May 26. Epub 2020 May 26.

Department of Infectious Diseases and Respiratory Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

Purpose: General conditions in the health-care system in Germany have changed dramatically in recent years. Factors affecting this include above all demographic change, rapid developments in diagnostic and therapeutic options, and the application of economic criteria to the health-care sector. This study aimed to establish the current status quo regarding conditions of work and training for young doctors in gynecology and obstetrics, analyze stress factors, and suggest potential improvements. Read More

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http://dx.doi.org/10.1007/s00404-020-05616-0DOI Listing

Executive function training in very preterm children: a randomized controlled trial.

Eur Child Adolesc Psychiatry 2020 May 26. Epub 2020 May 26.

Department of Neonatology, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.

Objective of the current study was to assess whether game-formatted executive function (EF) training, is effective in improving attention, EF and academic performance in very preterm and/or extremely low birthweight children aged 8-12 years. A multi-center, double-blind, placebo- and waitlist controlled randomized trial (NTR5365) in two academic hospitals in The Netherlands was performed. Eighty-five very preterm children with parent-rated attention problems on the Child Behavior Checklist were randomized to one of three treatment conditions: EF training, placebo training or waitlist condition. Read More

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http://dx.doi.org/10.1007/s00787-020-01561-0DOI Listing

The Impact of COVID-19 on Plastic Surgery Residency Training.

Aesthetic Plast Surg 2020 May 26. Epub 2020 May 26.

Clinic of Plastic and Reconstructive Surgery, Department of Medical Area (DAME), Academic Hospital of Udine, University of Udine, Udine, Italy.

Nowadays didactic and surgical activities for residents in the surgery field are less and less due to an increasing burden of documentation and "non-educational work." Considering the current lockdown due to the COVID-19 pandemic, it has never been so important to find different ways to allow residents to improve their knowledge. We asked all plastic and esthetic surgery residents in our country to fill out a questionnaire to investigate changes in their didactical activity and analyze problems about their professional growth in the last few months. Read More

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http://dx.doi.org/10.1007/s00266-020-01789-wDOI Listing

Safety and Efficacy of Bedside Peritoneal Dialysis Catheter Placement in the COVID-19 Era: Initial Experience at a New York City Hospital.

World J Surg 2020 May 26. Epub 2020 May 26.

Department of Surgery, New York Presbyterian Hospital-Weill Cornell Medicine, 525 East 68th Street Box 294, New York, NY, 10065, USA.

Introduction: Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is common in critically ill patients with COVID-19. Unparalleled numbers of patients with AKI and shortage of dialysis machines and operative resources prompted consideration of expanded use of urgent-start peritoneal dialysis (PD) and evaluation of the safety and efficacy of bedside surgical placement of PD catheters.

Study Design: Bedside, open PD catheter insertions were performed in early April 2020, at a large academic center in New York City. Read More

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http://dx.doi.org/10.1007/s00268-020-05600-4DOI Listing

Differential Diagnosis of Inflammatory Arthropathies by Musculoskeletal Ultrasonography: A Systematic Literature Review.

Front Med (Lausanne) 2020 7;7:141. Epub 2020 May 7.

UOC e Sezione di Reumatologia - Dipartimento di Scienze Mediche, Università degli Studi di Ferrara, Ferrara, Italy.

Differential diagnosis in early arthritis is challenging, especially early after symptom onset. Several studies applied musculoskeletal ultrasound in this setting, however, its role in helping diagnosis has yet to be clearly defined. The purpose of this work is to systematically assess the diagnostic applications of ultrasonography in early arthritis in order to summarize the available evidence and highlight possible gaps in knowledge. Read More

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http://dx.doi.org/10.3389/fmed.2020.00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221062PMC