240,565 results match your criteria Academic medicine : journal of the Association of American Medical Colleges[Journal]


Melioidosis: A Neglected Cause of Community-Acquired Pneumonia.

Semin Respir Crit Care Med 2020 Aug 6;41(4):496-508. Epub 2020 Jul 6.

Center for Experimental and Molecular Medicine, Amsterdam Infection & Immunity Institute, Amsterdam University Medical Centers, Location Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Melioidosis, caused by the facultative intracellular gram-negative pathogen , is an emerging cause of community-acquired pneumonia across the tropics. The majority of patients present with pneumonia with or without sepsis, but localized and asymptomatic infection is also well recognized. Recent modeling and epidemiological studies have demonstrated the widespread presence of in otherwise unrecognized regions with a predicted mortality of 90,000 deaths worldwide. Read More

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http://dx.doi.org/10.1055/s-0040-1710570DOI Listing

Relationship between Presence of Visceral Infarction and Functional Outcome among Patients with Acute Ischemic Stroke.

Cerebrovasc Dis 2020 Jul 6:1-5. Epub 2020 Jul 6.

Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, New York, New York, USA,

Introduction: Evidence of visceral infarction is often found in patients with acute ischemic stroke. It remains uncertain whether there exists a relationship between visceral infarction and functional outcomes among patients with stroke.

Objective: The aim of this study was to evaluate whether evidence of visceral infarction is associated with functional outcomes among patients with stroke. Read More

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http://dx.doi.org/10.1159/000508826DOI Listing

Kogan's Attitude toward Old People scale revisited: Psychometric properties and recommendations.

Arch Gerontol Geriatr 2020 Jun 23;90:104159. Epub 2020 Jun 23.

Department of Physiotherapy, Faculty of Health Sciences, University of Granada, Av de la Ilustración, 60, 1860, Granada, Spain.

Population ageing is one of the present and future challenges in the European context. In addition to age-related changes, negative and judicious attitudes by society are also prevalent. Therefore, there is a need for reliable instruments to evaluate attitudes toward ageing. Read More

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http://dx.doi.org/10.1016/j.archger.2020.104159DOI Listing

The development of grit and growth mindset during adolescence.

J Exp Child Psychol 2020 Jul 3;198:104889. Epub 2020 Jul 3.

Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Individual differences in grit and growth mindset predict effort and achievement in the face of challenges, but little is known about how the two traits influence each other during adolescence. In the current investigation, we analyzed data on grit and growth mindset collected from 1667 adolescents and their teachers on four occasions over 2 academic years. In autoregressive cross-lagged models, grit predicted rank-order increases in growth mindset and growth mindset predicted rank-order increases in grit. Read More

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http://dx.doi.org/10.1016/j.jecp.2020.104889DOI Listing

Establishing core outcome domains in pediatric kidney disease: report of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-KIDS) consensus workshops.

Kidney Int 2020 Jul 3. Epub 2020 Jul 3.

Sydney School of Public Health, The University of Sydney, Sydney, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, Australia.

Trials in children with chronic kidney disease (CKD) do not consistently report outcomes that are critically important to patients and caregivers. This can diminish the relevance and reliability of evidence for decision-making, limiting the implementation of results into practice and policy. As part of the Standardized Outcomes in Nephrology - Children and Adolescents (SONG-Kids) initiative, we convened two consensus workshops in San Diego, United States (7 patients, 24 caregivers, 43 health professionals; and Melbourne, Australia (7 patients, 23 caregivers, 49 health professionals). Read More

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http://dx.doi.org/10.1016/j.kint.2020.05.054DOI Listing

Mental health and dermatology practice in the COVID-19 pandemic.

Clin Exp Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Centre for Dermatology Research, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/ced.14330DOI Listing

In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis.

PLoS One 2020 6;15(7):e0235605. Epub 2020 Jul 6.

Nuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, United Kingdom.

Introduction: Paediatric consultations form a significant proportion of all consultations in ambulatory care. Point-of-care tests (POCTs) may offer a potential solution to improve clinical outcomes for children by reducing diagnostic uncertainty in acute illness, and streamlining management of chronic diseases. However, their clinical impact in paediatric ambulatory care is unknown. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235605PLOS

A systematic review and evidence synthesis of non-medical triage, self-referral and direct access services for patients with musculoskeletal pain.

PLoS One 2020 6;15(7):e0235364. Epub 2020 Jul 6.

Arthritis Research UK Primary Care Centre, School of Primary, Community & Social Care, Keele University, Keele, United Kingdom.

Introduction: The demand for musculoskeletal (MSK) care is rising, and is a growing challenge for general practice. Direct access to physiotherapy and other healthcare services may offer appropriate care for MSK pain patients but there is uncertainty regarding the effectiveness or efficiency of this approach in practice. This study aimed to review the evidence regarding characteristics, outcomes, barriers and facilitators of MSK triage and direct access services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235364PLOS

Violence against trainees: urgent ethical challenges for medical educators and academic leaders in perinatal medicine.

J Perinat Med 2020 Jul 7. Epub 2020 Jul 7.

Department of Obstetrics and Gynecology, Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, New York, NY, USA.

Objectives Violence against medical trainees confronts medical educators and academic leaders in perinatal medicine with urgent ethical challenges. Despite their evident importance, these ethical challenges have not received sufficient attention. The purpose of this paper is to provide an ethical framework to respond to these ethical challenges. Read More

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http://dx.doi.org/10.1515/jpm-2020-0123DOI Listing

Data Integration in the Brazilian Public Health System for Tuberculosis: Use of the Semantic Web to Establish Interoperability.

JMIR Med Inform 2020 Jul 6;8(7):e17176. Epub 2020 Jul 6.

Department of Social Medicine of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Background: Interoperability of health information systems is a challenge due to the heterogeneity of existing systems at both the technological and semantic levels of their data. The lack of existing data about interoperability disrupts intra-unit and inter-unit medical operations as well as creates challenges in conducting studies on existing data. The goal is to exchange data while providing the same meaning for data from different sources. Read More

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http://dx.doi.org/10.2196/17176DOI Listing

Technological Prospection of Oil Nanoparticles: Primary Characteristics and Profiles.

Recent Pat Nanotechnol 2020 Jul 5. Epub 2020 Jul 5.

Nutrition School, Federal University of Bahia, Salvador. Brazil.

Background: The search for technological applications for oils has been growing, largely due to their potential nutritional and economic applications. Encapsulation makes it possible to reduce the disadvantages of oils, such as physical instability or thermodynamics, or to improve their technological properties, enabling their use in various industrial areas. Nanoencapsulated oils have the potential to improve oil bioavailability and achieve controlled release and are able to target bioactive compounds with greater precision than microencapsulated oils. Read More

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http://dx.doi.org/10.2174/1872210514666200705234030DOI Listing

Ten Years of : Authorship Characteristics and Levels of Evidence.

Sports Health 2020 Jul 6:1941738120922163. Epub 2020 Jul 6.

Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.

Context: , now 10 years into production, has been ranked a top-25 journal in sport sciences and has tripled its impact throughout its existence.

Objective: To evaluate authorship trends and levels of evidence (LOE) of articles published in from 2009 to 2018. The secondary aim was to analyze funding sources and internationalization throughout the journal's tenure. Read More

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http://dx.doi.org/10.1177/1941738120922163DOI Listing

Image-Guided Surgical e-Learning in the Post-COVID-19 Pandemic Era: What Is Next?

J Laparoendosc Adv Surg Tech A 2020 Jul 6. Epub 2020 Jul 6.

Department of Image-Guided Liver Interventions, IHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France.

The current unprecedented coronavirus 2019 (COVID-19) crisis has accelerated and enhanced e-learning solutions. During the so-called transition phase, efforts were made to reorganize surgical services, reschedule elective surgical procedures, surgical research, academic education, and careers to optimize results. The intention to switch to e-learning medical education is not a new concern. Read More

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http://dx.doi.org/10.1089/lap.2020.0535DOI Listing

In Children and Adolescents From Brugada Syndrome-Families, Only Mutation Carriers Develop a Type-1 ECG Pattern Induced By Fever.

Circulation 2020 Jul 6;142(1):89-91. Epub 2020 Jul 6.

Department of Pediatric Cardiology, Emma Children's Hospital (P.J.P, N.A.B., A.S.V., S.-A.B.C.), Amsterdam University Medical Center, location Academic Medical Center (AMC), The Netherlands.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.120.045720DOI Listing

Qualitative Assessment of Rapid System Transformation to Primary Care Video Visits at an Academic Medical Center.

Ann Intern Med 2020 Jul 6. Epub 2020 Jul 6.

Stanford University School of Medicine, Palo Alto, California (M.S., S.A., S.V., L.B., M.M., I.N., A.J.P., M.A.).

Background: The coronavirus disease 2019 pandemic spurred health systems across the world to quickly shift from in-person visits to safer video visits.

Objective: To seek stakeholder perspectives on video visits' acceptability and effect 3 weeks after near-total transition to video visits.

Design: Semistructured qualitative interviews. Read More

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http://dx.doi.org/10.7326/M20-1814DOI Listing

The influence of size and abiotic factors on cutaneous water loss.

Adv Physiol Educ 2020 Sep;44(3):387-393

Department of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois.

The greatest physiological threat to terrestrial life is dehydration; however, examining the factors that influence water balance in a teaching setting can be problematic. The proposed exercise examines cutaneous water loss using gelatin frogs. The use of models provides a unique approach to learning about water loss without the need of Institutional Animal Care and Use Committee approval or specialized equipment to measure dehydration from relatively small invertebrates. Read More

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http://dx.doi.org/10.1152/advan.00152.2019DOI Listing
September 2020

Flipped classroom improves results in pathophysiology learning: results of a nonrandomized controlled study.

Adv Physiol Educ 2020 Sep;44(3):370-375

Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Spain.

The flipped classroom has become increasingly popular in health professions education. The aim of this study was to analyze its effect on learning in a pathophysiology course. Flipped classroom was introduced to teach respiratory pathophysiology in 2018. Read More

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http://dx.doi.org/10.1152/advan.00153.2019DOI Listing
September 2020

2020 Consensus of Taiwan Society of Cardiology on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases.

J Chin Med Assoc 2020 Jul;83(7):587-621

aGeneral Clinical Research Center, Taipei Veterans General Hospital, Taipei, Taiwan, ROC bDivision of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC cSchool of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC dChung-Shan Medical University Hospital, Taichung, Taiwan, ROC eDepartment of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC fDepartment of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC gDepartment of Medicine, Mackay Medical College, New Taipei City, Taiwan, ROC hCardiovascular Center, Department of Internal Medicine, MacKay Memorial Hospital, Taipei, Taiwan, ROC iDepartment of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC jDepartment of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC kInstitute of Public Health and Community Medicine Research Center, National Yang-Ming University, Taipei, Taiwan, ROC lDivision of Cardiology, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC mInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC nDivision of Cardiovascular Medicine, China Medical University Hospital, Taichung, Taiwan, ROC oSchool of Medicine, China Medical University, Taichung, Taiwan, ROC pDivision of Cardiology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC qCardiovascular center, Taichung Veterans General Hospital, Taichung, Taiwan, ROC rDepartment of Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC sDivision of Cardiology, Department of Internal Medicine, Hsinchu Mackay Memorial Hospital, Hsinchu, Taiwan, ROC tInstitute of Clinical Medicine, and Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan, ROC uDivision of Cardiology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan, ROC uCenter for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC vInstitute of Public Health, National Yang-Ming University, Taipei, Taiwan, ROC wInstitute of Health and Welfare Policy, National Yang-Ming University, Taipei, Taiwan, ROC xDepartment of Cardiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC ySchool of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC zHeart Center, Cheng Hsin General Hospital, Taipei, Taiwan, ROC aaDivision of Cardiology, Cardiovascular Medical Center, and Department of Nuclear, ROC Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan, ROC abDepartment of Internal Medicine and Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC acDivision of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, ROC adTaipei Heart Institute, Taipei Medical University, Taipei, Taiwan, ROC aeDepartment of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan, ROC afInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC agCardiovascular Division, Department of Internal Medicine, National Taiwan, ROC, University College of Medicine and Hospital, Taipei, Taiwan, ROC ahCardiovascular Center, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan, ROC.

The global incidence and prevalence of type 2 diabetes have been escalating in recent decades. The total diabetic population is expected to increase from 415 million in 2015 to 642 million by 2040. Patients with type 2 diabetes have an increased risk of atherosclerotic cardiovascular disease (ASCVD). Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000359DOI Listing

How can care settings for people with intellectual disabilities embed health promotion?

J Appl Res Intellect Disabil 2020 Jul 6. Epub 2020 Jul 6.

Department of Primary and Community Care, Intellectual Disabilities and Health, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.

Background: People with intellectual disabilities (ID) depend on their environment to live healthily. Asset-based health promotion enhances a settings' health-promoting capacity starting with identifying protective or promotive factors that sustain health.

Method: This inclusive mixed-methods study used group sessions to generate and rank ideas on assets supporting healthy nutrition and physical activity in Dutch intellectual disability care settings. Read More

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http://dx.doi.org/10.1111/jar.12776DOI Listing

Transcatheter aortic valve implantation (TAVI) in cardiogenic shock: TAVI-shock registry results.

Catheter Cardiovasc Interv 2020 Jul 6. Epub 2020 Jul 6.

Interventional Cardiology Unit, Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Objectives: Aim of this study is to evaluate safety, feasibility, and mid-term outcome of transcatheter aortic valve implantation (TAVI) in cardiogenic shock (CS).

Background: Balloon aortic valvuloplasty in patients with severe aortic valve stenosis (SAS) complicated by CS is indicated but associated with a grim prognosis. TAVI might be a more reasonable treatment option in this setting but data are scant. Read More

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http://dx.doi.org/10.1002/ccd.29112DOI Listing

Large-Scale Fabrication of Robust Artificial Skins from a Biodegradable Sealant-Loaded Nanofiber Scaffold to Skin Tissue via Microfluidic Blow-Spinning.

Adv Mater 2020 Jul 6:e2000982. Epub 2020 Jul 6.

Department of General Surgery, Jinling Hospital, Nanjing Medical University, Nanjing, 210002, P. R. China.

Given that many people suffer from large-area skin damage, skin regeneration is a matter of high concern. Here, an available method is developed for the formation of large-area robust skins through three stages: fabrication of a biodegradable sealant-loaded nanofiber scaffold (SNS), skin tissue reconstruction, and skin regeneration. First, a microfluidic blow-spinning strategy is proposed to fabricate a large-scale nanofiber scaffold with an area of 140 cm × 40 cm, composed of fibrinogen-loaded polycaprolactone/silk fibroin (PCL/SF) ultrafine core-shell nanofibers with mean diameter of 65 nm. Read More

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http://dx.doi.org/10.1002/adma.202000982DOI Listing

Increased long-term mortality after emergency colon resections.

Colorectal Dis 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, St. Antonius Hospital, Nieuwegein, The Netherlands.

Aim: Emergency surgery is a known predictor for 30-day mortality. However, the relationship with long-term mortality is still a matter of debate. The aim of this study was to analyse the effect of emergency surgery compared to elective surgery on long-term survival. Read More

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http://dx.doi.org/10.1111/codi.15238DOI Listing

Magnetic fields modulate metabolism and gut microbiome in correlation with Pgc-1α expression: Follow-up to an in vitro magnetic mitohormetic study.

FASEB J 2020 Jul 6. Epub 2020 Jul 6.

Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Exercise modulates metabolism and the gut microbiome. Brief exposure to low mT-range pulsing electromagnetic fields (PEMFs) was previously shown to accentuate in vitro myogenesis and mitochondriogenesis by activating a calcium-mitochondrial axis upstream of PGC-1α transcriptional upregulation, recapitulating a genetic response implicated in exercise-induced metabolic adaptations. We compared the effects of analogous PEMF exposure (1. Read More

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http://dx.doi.org/10.1096/fj.201903005RRDOI Listing

Chemical sensing platforms for detecting trace-level Alzheimer's core biomarkers.

Chem Soc Rev 2020 Jul 6. Epub 2020 Jul 6.

Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), 335 Science Road, Daejeon 305-701, Republic of Korea.

Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder and affects more than 10% of the population aged over 65 worldwide. Despite considerable global efforts, AD patients can only be diagnosed after the onset of symptoms based on neuropsychological tests and neuroimaging. Because the changes in the levels of biomarkers associated with Aβ deposits and tau tangles precede the appearance of the first cognitive symptoms, accurate measurements of AD core biomarkers is critical for identifying asymptomatic AD patients and predicting disease progression. Read More

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http://dx.doi.org/10.1039/d0cs00107dDOI Listing

Conscience and conscientious objection: The midwife's role in abortion services.

Nurs Ethics 2020 Jul 6:969733020928416. Epub 2020 Jul 6.

Liverpool John Moores University, UK.

Traditionally, the role of midwives has been to be with women throughout the pregnancy continuum, from conception until the end of the postnatal period. Midwives, however, have been named as key providers of abortion services. While freedom of conscience is legally protected within Europe, discrepancies exist between midwifery and conscientious objection to abortion-related services. Read More

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http://dx.doi.org/10.1177/0969733020928416DOI Listing

Marijuana Use for Women: To Prescribe or Not to Prescribe.

Subst Use Misuse 2020 Jul 5:1-2. Epub 2020 Jul 5.

Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

The marijuana policy varies greatly worldwide. Marijuana use is illegal in most countries. Nevertheless, the medical potentials of marijuana have been increasingly uncovered, and its use by women is increasing. Read More

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http://dx.doi.org/10.1080/10826084.2020.1782938DOI Listing

A comparative study of an assistive e-learning interface among students with and without visual and hearing impairments.

Disabil Rehabil Assist Technol 2020 Jul 6:1-11. Epub 2020 Jul 6.

Faculty of Management, Al Ain University, Abu Dhabi, UAE.

Using a human-computer interaction (HCI) approach, the present study proposes a new e-learning interface with interactional features for use by students with varying visual and hearing needs. Prototypes of these new features have been presented through several screens, including an interaction panel that allows for Button voice, Tab voice, Text voice, and sign language. The interactive features were evaluated by teachers and tested by students with and without visual and hearing impairments. Read More

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http://dx.doi.org/10.1080/17483107.2020.1786733DOI Listing

The efficacy of biofeedback visual rehabilitation therapy in patients with infantile nystagmus syndrome: A retrospective study.

Eur J Ophthalmol 2020 Jul 6:1120672120940981. Epub 2020 Jul 6.

Academic Ophthalmology, Division of Clinical Neurosciences, Queen's Medical Centre, University of Nottingham, Nottingham, UK.

Objective: To report fixation stability changes in patients with different forms of infantile nystagmus syndrome (INS), who have undergone a visual rehabilitation through biofeedback fixation training (BFT) with microperimetry (MP).

Design: Retrospective study.

Methods: Patients 6 to 12 years-old with INS who performed BFT with MP. Read More

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http://dx.doi.org/10.1177/1120672120940981DOI Listing

Predicting Nasal Soft Tissue Envelope Thickness for Rhinoplasty: A Model Based on Visual Examination of the Nose.

Ann Otol Rhinol Laryngol 2020 Jul 4:3489420937720. Epub 2020 Jul 4.

Chair, Division of Facial Plastic & Reconstructive Surgery, Department of Otolaryngology-Head & Neck Surgery, Mayo Clinic, Rochester, MN, USA.

Importance: Predicting nasal soft tissue envelope (STE) thickness is an important component of the preoperative evaluation for rhinoplasty that presently lacks validated tools.

Objective: Assess for patient facial features and factors that can help predict nasal STE thickness.

Design, Setting, And Participants: Retrospective review and prospective assessment conducted at an academic tertiary referral center. Read More

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http://dx.doi.org/10.1177/0003489420937720DOI Listing

Understanding the role of the academic assessor.

Nurs Stand 2020 Jul 6. Epub 2020 Jul 6.

Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University, Cambridge, England.

Publication of the Nursing and Midwifery Council's standards for student supervision and assessment introduced the role of academic assessor. However, there has been little research into the role and what it entails. This article examines the role of academic assessor and discusses who can become an academic assessor, their responsibilities, and the potential challenges and benefits associated with the role. Read More

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http://dx.doi.org/10.7748/ns.2020.e11463DOI Listing

[Advances in quality research of Cinnamomum cassia].

Zhongguo Zhong Yao Za Zhi 2020 Jun;45(12):2792-2799

School of Chinese Materia Medica, Guangdong Pharmaceutical University Guangzhou 510006, China Key Laboratory of State Administration of Traditional Chinese Medicine for Production & Development of Cantonese Medicinal Materials Guangzhou 510006, China.

Cinnamomum cassis is one of the commonly used traditional Chinese medicines in China. Its genuine producing areas distribute in Guangdong and Guangxi provinces. As an important edible herb and export variety of China, the quality control and internationalization of quality standards of C. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191106.202DOI Listing

Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer.

Head Neck 2020 Jul 6. Epub 2020 Jul 6.

European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium.

Background: We aimed to estimate minimally important difference (MID) for interpreting group-level change over time for European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire core 30 (EORTC QLQ-C30) scores in head and neck cancer.

Methods: Data were derived retrospectively from two published EORTC trials. Clinical anchors were selected using correlation strength and clinical plausibility of the given anchor/QLQ-C30 scale pair. Read More

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http://dx.doi.org/10.1002/hed.26363DOI Listing

A profile of Australian occupational therapy academic workforce job satisfaction.

Aust Occup Ther J 2020 Jul 5. Epub 2020 Jul 5.

School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, Australia.

Introduction: There has been an increase in the number of Australian occupational therapy education programmes and student enrolment numbers in existing programmes, whereas there is a perceived current and predicted future workforce shortage of qualified university academics. The aim of the study was to map the current Australian occupational therapy academic workforce and investigate the group's job satisfaction.

Methods: The research was a cross-sectional online survey of Australian occupational therapy academics employed part-time or full-time in fixed or ongoing positions. Read More

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http://dx.doi.org/10.1111/1440-1630.12683DOI Listing

Institutional variation in recovery after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: An opportunity for enhanced recovery pathways.

J Surg Oncol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, City of Hope National Medical Center, Duarte, California.

Background: Variations in care have been demonstrated both within and among institutions in many clinical settings. By standardizing perioperative practices, Enhanced Recovery After Surgery (ERAS) pathways reduce variation in perioperative care. We sought to characterize the variation in cytoreductive surgery (CRS)/heated intraperitoneal chemotherapy (HIPEC) perioperative practices among experienced US medical centers. Read More

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http://dx.doi.org/10.1002/jso.26099DOI Listing

[Sleep and academic performance in university students: a systematic review].

Rev Neurol 2020 Jul;71(2):43-53

Universidad del Estado de Pensilvania , Derry, EEUU.

Introduction: University students tend to suffer from problems of sleep regularity, quantity and quality, which can affect their academic performance. These problems are related to changes typical of the phase of the life cycle in which they find themselves due to maturational, psychosocial development (associated with the processes of individuation and socialisation) and academic factors. The study of the relationship between sleep and academic performance in university students is an area of research of growing interest, which has started to be studied over the last two decades. Read More

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http://dx.doi.org/10.33588/rn.7102.2020015DOI Listing

Characteristics of Reported Pediatric Medication Errors in Northern Ireland and Use in Quality Improvement.

Paediatr Drugs 2020 Jul 6. Epub 2020 Jul 6.

Centre for Medical Education, Queen's University Belfast, Whitla Medical Building, 97 Lisburn Road, Belfast, UK.

Background: To protect children from harm, clinicians, educators, and patient safety champions need information to direct improvement efforts. Critical incident data could provide this but are often disregarded as a source of evidence because under-reporting makes them an inaccurate measure of error rates.

Objective: Our aim was to identify key targets for pediatric healthcare quality improvement. Read More

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http://dx.doi.org/10.1007/s40272-020-00407-1DOI Listing

Study protocol of a pilot study on sirolimus-coated balloon angioplasty in salvaging clotted arteriovenous graft.

CVIR Endovasc 2020 Jul 5;3(1):34. Epub 2020 Jul 5.

Department of Renal Medicine, Singapore General Hospital, Academia, Level 3, 20 College Road, Singapore, 169856, Singapore.

Background: In arteriovenous graft (AVG) for haemodialysis, the primary cause of failure is venous stenosis of the graft-vein junction from neointimal hyperplasia (NIH), resulting in thrombosis. While interventions to salvage clotted AVG are known to have high clinical success rates, long-term patency rates have been suboptimal. Drug-coated balloon (DCB) has been used to treat stenosed arteriovenous access in recent years with encouraging results but data on its effect in clotted AVG is unavailable. Read More

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http://dx.doi.org/10.1186/s42155-020-00123-4DOI Listing

Placental exosomes isolated from urine of patients with gestational diabetes exhibit a differential profile expression of microRNAs across gestation.

Int J Mol Med 2020 Aug 3;46(2):546-560. Epub 2020 Jun 3.

CONACyT, Metabolomics and Proteomics Laboratory, Academic Unit of Biological Sciences, Universidad Autónoma de Zacatecas, Zacatecas 98068, Mexico.

Placenta‑derived exosomes play an important role in cellular communication both in the mother and the fetus. Their concentration and composition are altered in several pregnancy disorders, such as gestational diabetes mellitus (GDM). The isolation and characterization of placental exosomes from serum, plasma and tissues from patients with GDM have been previously described; however, to the best of our knowledge, to date, there is no study available on placental exosomes isolated from urine of patients with GDM. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4626DOI Listing

Computed tomography scanning in the prone position for a critically hypoxic patient with COVID-19.

Anaesth Rep 2020 Jan-Jun;8(1):71-72. Epub 2020 Jun 30.

Manchester University Hospital NHS Foundation Trust Manchester UK.

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http://dx.doi.org/10.1002/anr3.12050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325509PMC

Efficacy of antiepileptic drugs in neonatal seizures: a systematic review protocol.

BMJ Paediatr Open 2020 29;4(1):e000683. Epub 2020 Jun 29.

Key Laboratory of Obstetrics & Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of Education, Sichuan University, Chengdu, China.

Introduction: Seizures are one of the most common neurological disorders of neonates, which is also an emergency in the neonatal intensive care unit. For neonates, the recommended first-line antiepileptic drugs (AEDs) include phenobarbitone, which may be effective in only 50% of seizures. Some new AEDs, such as levetiracetam, have been shown to be effective in adults and older children. Read More

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http://dx.doi.org/10.1136/bmjpo-2020-000683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326240PMC

Maximizing human effort for analyzing scientific images: A case study using digitized herbarium sheets.

Appl Plant Sci 2020 Jun 1;8(6):e11370. Epub 2020 Jul 1.

Florida Museum of Natural History University of Florida Gainesville Florida USA.

Premise: Digitization and imaging of herbarium specimens provides essential historical phenotypic and phenological information about plants. However, the full use of these resources requires high-quality human annotations for downstream use. Here we provide guidance on the design and implementation of image annotation projects for botanical research. Read More

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http://dx.doi.org/10.1002/aps3.11370DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328657PMC

Isocitrate dehydrogenase 1 mutant glioblastomas demonstrate a decreased rate of pseudoprogression: a multi-institutional experience.

Neurooncol Pract 2020 Mar 10;7(2):185-195. Epub 2019 Oct 10.

Department of Radiation Oncology, Indiana University Simon Cancer Center, Indianapolis, USA.

Background: Pseudoprogression (psPD) represents false radiologic evidence of tumor progression and is observed in some glioblastoma (GBM) patients after postoperative chemoradiation (CRT) with temozolomide (TMZ). The ambiguity of the psPD diagnosis confounds identification of true progression and may lead to unnecessary interventions. The association between psPD and isocitrate dehydrogenase 1 () mutational (mut) status is understudied, and its incidence may alter clinical decision making. Read More

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http://dx.doi.org/10.1093/nop/npz050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318854PMC

Advancing human health risk assessment.

EFSA J 2019 Jul 8;17(Suppl 1):e170712. Epub 2019 Jul 8.

Formerly World Health Organisation Geneva CH.

The current/traditional human health risk assessment paradigm is challenged by recent scientific and technical advances, and ethical demands. The current approach is considered too resource intensive, is not always reliable, can raise issues of reproducibility, is mostly animal based and does not necessarily provide an understanding of the underlying mechanisms of toxicity. From an ethical and scientific viewpoint, a paradigm shift is required to deliver testing strategies that enable reliable, animal-free hazard and risk assessments, which are based on a mechanistic understanding of chemical toxicity and make use of exposure science and epidemiological data. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.e170712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015480PMC

Facing the challenges of science communication 2.0: quality, credibility and expertise.

EFSA J 2019 Jul 8;17(Suppl 1):e170702. Epub 2019 Jul 8.

Università di Trento.

What are the key challenges for science communication in the age of digital media? Are they entirely new or rather occurring in a different communicative context of longstanding issues pertaining to the credibility and reliability of information and the role of experts? Mystification for propaganda, also involving scientific content and scientists themselves, has certainly not been introduced with the internet. In a context of 'crisis of mediators', the quality of public communication of science is - even more than in the past - highly dependent on the quality of research produced and published in specialised contexts. New research is increasingly pushed in real time into the public domain without being 'filtered', as was the case in the past decades, by professional mediators and popularisers. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.e170702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015522PMC

Individuals vs. BARD: Experimental Evaluation of an Online System for Structured, Collaborative Bayesian Reasoning.

Front Psychol 2020 18;11:1054. Epub 2020 Jun 18.

Faculty of Information Technology, Monash University, Melbourne, VIC, Australia.

US intelligence analysts must weigh up relevant evidence to assess the probability of their conclusions, and express this reasoning clearly in written reports for decision-makers. Typically, they work alone with no special analytic tools, and sometimes succumb to common probabilistic and causal reasoning errors. So, the US government funded a major research program (CREATE) for four large academic teams to develop new structured, collaborative, software-based methods that might achieve better results. Read More

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http://dx.doi.org/10.3389/fpsyg.2020.01054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314942PMC

Investigation of Invigorating and Activating Blood Circulation Prescriptions in Treating Deficiency and Blood Stasis Syndrome of Ischemic Stroke Patients: Study Protocol for a Randomized Controlled Trial.

Front Pharmacol 2020 17;11:892. Epub 2020 Jun 17.

Institute of Cardio-cerebrovascular Disease, Zhejiang Chinese Medical University, Hangzhou, China.

Ischemic stroke (IS) is characterized by high morbidity and high mortality. The integration of Traditional Chinese medicine (TCM) and western medicine has shown promising benefits in relieving symptoms, promoting neurological recovery, and improving the quality of life of patients with IS. In TCM, -deficiency along with blood-stasis (QDBS) syndrome is one of the common types of IS that is treated by invigorating and activating blood circulation. Read More

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http://dx.doi.org/10.3389/fphar.2020.00892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311665PMC

Polygenic risk score opportunities for early detection and prevention strategies in endometrial cancer.

Br J Cancer 2020 Jul 6. Epub 2020 Jul 6.

Division of Cancer Sciences, Faculty of Biology, Medicine and Health, University of Manchester, St Mary's Hospital, Manchester, UK.

Recent large-scale genetic studies, particularly genome-wide association studies (GWAS), have emphasised the importance of common genetic variation in endometrial cancer susceptibility. Although each of these variants only confer modest effects on endometrial cancer risk, together they are likely to explain a substantial amount of the familial relative risk of the disease. Therefore, methods to combine genetic risk variants, such as polygenic risk scores (PRS) have gained traction as an attractive method for individualised risk prediction and management. Read More

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http://dx.doi.org/10.1038/s41416-020-0959-7DOI Listing

High Bleeding Risk and Clinical Outcomes in East Asian Patients Undergoing Percutaneous Coronary Intervention: the PENDULUM Registry.

EuroIntervention 2020 Jul 7. Epub 2020 Jul 7.

Division of Cardiovascular Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.

Aims: We evaluated the validity of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) criteria for East Asian patients undergoing contemporary percutaneous coronary intervention (PCI) from the PENDULUM registry.

Methods And Results: This post hoc analysis included 6,267 Japanese patients undergoing PCI between December 2015 and June 2017 enrolled in PENDULUM. The primary endpoint was incidence of major bleeding at 12 months post-index PCI. Read More

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http://dx.doi.org/10.4244/EIJ-D-20-00345DOI Listing