240,984 results match your criteria Academic emergency medicine : official journal of the Society for Academic Emergency Medicine[Journal]


SARS-CoV-2: An immunogenetics call to arms.

Int J Immunogenet 2020 Jul 12. Epub 2020 Jul 12.

Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK.

Susceptibility to viral infection, development of immunity, response to treatment and patient clinical outcomes are all under the control of heritable factors in the host. In the context of the current SARS-Cov-2 pandemic, this review considers existing immunogenetic knowledge of virus-immune system interactions. A major focus is to highlight areas in which work is required in order to improve understanding of antiviral immune responses and to move towards improved patient management. Read More

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http://dx.doi.org/10.1111/iji.12504DOI Listing

Debate: COVID-19 and psychological well-being of children and adolescents in Italy.

Child Adolesc Ment Health 2020 Jul 12. Epub 2020 Jul 12.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Italy was the first country in Europe to deal with COVID-19. Measures taken by the government to contain the spread of the virus were based mainly on quarantine and social distancing, with dramatic economic, social and psychological consequences. Since March, Italian children and adolescents are facing school closures, which have caused a disruption in the daily lives of millions of young people and their families. Read More

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http://dx.doi.org/10.1111/camh.12405DOI Listing

The impact of COVID-19 on dental education in North America-Where do we go next?

Eur J Dent Educ 2020 Jul 12. Epub 2020 Jul 12.

Faculty of Dentistry, McGill University, Montreal, QC, Canada.

During the COVID-19 pandemic, the dental education community faced unprecedented challenges. In this commentary, we share the perspectives of faculty clinicians, residents and students in academic dental institutions in the United States and Canada. We discuss COVID-19's impact on various aspects of academic dentistry including patient care, education, research and raise key concerns regarding the future of dental education post-pandemic. Read More

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http://dx.doi.org/10.1111/eje.12561DOI Listing

Vascular endothelial growth factor-A as a promising therapeutic target for the management of psoriasis.

Exp Dermatol 2020 Jul 12. Epub 2020 Jul 12.

Centre for Dermatology Research and Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

Vascular endothelial growth factor-A (VEGF-A), the main angiogenic mediator, plays a critical role in the pathogenesis of several inflammatory immune-mediated diseases, including psoriasis. Even though anti-angiogenic therapies, such as VEGF inhibitors, are licensed for the treatment of various cancers and eye disease, VEGF-targeting interventions are not part of current psoriasis therapy. In this Viewpoint essay, we argue that the existing preclinical research evidence on the role of VEGF-A in the pathogenesis of psoriasis as well as clinical observations in patients that have experienced psoriasis remission during oncological anti-VEGF-A therapy, strongly suggest to systematically explore angiogenesis targeting also in the management of psoriasis. Read More

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http://dx.doi.org/10.1111/exd.14151DOI Listing

Validation of the Warwick-Edinburgh Mental Well-being Scale among nursing students in Slovenia.

J Nurs Manag 2020 Jul 12. Epub 2020 Jul 12.

University of Maribor, Faculty of Health Sciences, Žitna ulica 15, 2000, Maribor, Slovenia.

Aim: The aim of this study was to assess the validity of the Warwick-Edinburgh Mental Well-being Scale used for measuring mental well-being.

Background: Nursing students' mental well-being is often poor due to various academic and personal stressors. Nursing students are involved in clinical practice and are facing birth, death, health, diseases, and other stressful situations. Read More

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http://dx.doi.org/10.1111/jonm.13087DOI Listing

Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Research Center, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada.

Cardiomyocyte migration represents a requisite event of cardiogenesis and the regenerative response of the injured adult zebrafish and neonatal rodent heart. The present study tested the hypothesis that the appearance of the intermediate filament protein nestin in neonatal rat ventricular cardiomyocytes (NNVMs) was associated in part with the acquisition of a migratory phenotype. The cotreatment of NNVMs with phorbol 12,13-dibutyrate (PDBu) and the p38α/β mitogen-activated protein kinase inhibitor SB203580 led to the de novo synthesis of nestin. Read More

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http://dx.doi.org/10.1002/jcp.29934DOI Listing

Determination of intra-oral surface areas by cone-beam computed tomography analysis and their relation with anthrometric measurements of the head.

Surg Radiol Anat 2020 Jul 11. Epub 2020 Jul 11.

Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Room 12 N-37, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.

Purpose: Determination of intra-oral surface areas might contribute to our understanding of the physiology of the oral cavity and oral diseases. In previous studies, the intra-oral surface area was determined using a laborious and technically challenging method. Our aim was to develop an easy and non-invasive method to determine the intra-oral surface areas. Read More

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http://dx.doi.org/10.1007/s00276-020-02530-7DOI Listing

Comment on: Prevalence of extra-articular manifestations in psoriatic arthritis: Response.

Rheumatology (Oxford) 2020 Jul 12. Epub 2020 Jul 12.

Department of Biostatistics, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

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http://dx.doi.org/10.1093/rheumatology/keaa182DOI Listing

Coexistence of systemic and localized scleroderma: a systematic literature review and observational cohort study.

Rheumatology (Oxford) 2020 Jul 12. Epub 2020 Jul 12.

Department of Internal Medicine Ghent University.

Objective: SSc and localized sclerosis (LoS) are considered clinically distinct entities. We describe herein the coexistence of SSc and LoS by both a systematic literature review and an observational cohort study of unselected SSc patients.

Methods: Original studies documenting the coexistence of SSc and LoS were identified in three electronic databases by means of a systematic literature search according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa297DOI Listing

Cancer incidence and treatment utilization patterns at a regional cancer center in Tanzania from 2008-2016: Initial report of 2,772 cases.

Cancer Epidemiol 2020 Jul 9;67:101772. Epub 2020 Jul 9.

Bugando Medical Centre, Mwanza, Tanzania; Duke Global Health Institute, Duke University, Durham, NC, USA; Department of Pediatric Hematology/Oncology, Duke University, Durham, NC, USA. Electronic address:

Purpose: To describe cancer incidence and treatment utilization patterns at the regional cancer referral center for the Lake Zone of northwestern Tanzania from 2008 to 2016.

Methods: This descriptive, retrospective study reviewed all cancer cases recorded in the Bugando Cancer Registry (BCR), a clinical and pathology based registry at the only cancer referral hospital in the region. Primary tumor site, method of diagnosis, HIV status, and cancer treatment were reported. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101772DOI Listing

Sustaining the quality of midwifery practice in Belgium: Challenges and opportunities for advanced midwife practitioners.

Midwifery 2020 Jul 5;89:102792. Epub 2020 Jul 5.

University Centre for Nursing & Midwifery Department of Public Health and Primary Care Faculty of Medicine and Health Sciences, Ghent University Centre for Nursing & Midwifery, Ghent University, U.Z. 5K3 Corneel Heymanslaan 10, B-9000, Ghent, Belgium; Nursing Department, University Hospital Ghent, Corneel Heymanslaan 10, B-9000, Ghent, Belgium.. Electronic address:

Background: Midwifery practice is essential in achieving high-quality maternal and newborn care in all settings and countries. However, midwifery practice has become more complex over the past decades. Considerable demands are being placed on midwives to meet increasing epidemiological, socio-economic, and technological challenges. Read More

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http://dx.doi.org/10.1016/j.midw.2020.102792DOI Listing

Design and Pharmacological Profile of a Novel Covalent Partial Agonist for the Adenosine A Receptor.

Biochem Pharmacol 2020 Jul 9:114144. Epub 2020 Jul 9.

Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, P.O. Box 9502, 2300RA Leiden, The Netherlands. Electronic address:

Partial agonists for G protein-coupled receptors (GPCRs) provide opportunities for novel pharmacotherapies with enhanced on-target safety compared to full agonists. For the human adenosine A receptor (hAAR) this has led to the discovery of capadenoson, which has been in phase IIa clinical trials for heart failure. Accordingly, the design and profiling of novel hAAR partial agonists has become an important research focus. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114144DOI Listing

Uretero-Enteric Anastomotic Stricture Following Radical Cystectomy: A Comparison of Open, Robotic Extracorporeal, And Robotic Intracorporeal Approaches.

Urology 2020 Jul 9. Epub 2020 Jul 9.

Cleveland Clinic Foundation, Glickman Urological and Kidney Institute, Department of Urology, Cleveland, OH, USA.

Objectives: To compare the incidence of benign uretero-enteric anastomotic strictures between open cystectomy, robotic cystectomy with extracorporeal urinary diversion, and robotic cystectomy with intracorporeal urinary diversion. The effect of surgeon learning curve on stricture incidence following intracorporeal diversion was investigated as a secondary outcome.

Patients And Methods: Patients who underwent radical cystectomy at an academic hospital between 2011 and 2018 were retrospectively reviewed. Read More

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http://dx.doi.org/10.1016/j.urology.2020.06.047DOI Listing

Surgery Resident Perceptions of the Clicker Evaluation System: A Novel Approach to Collecting and Utilizing Clinical Faculty Performance Data.

J Surg Educ 2020 Jul 8. Epub 2020 Jul 8.

Department of Orthopaedic Surgery, Virginia Commonwealth University Health, Richmond, Virginia.

Objective: Medical trainees often have a process in place to receive feedback from clinical faculty regarding overall performance. While there is guidance on effective methodologies for faculty to provide feedback for learners, there is a dearth of literature analyzing trainees' evaluation of faculty performance. We sought to identify an effective and anonymous method for surgery residents to evaluate clinical faculty. Read More

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http://dx.doi.org/10.1016/j.jsurg.2020.06.021DOI Listing

HOME SAMPLING IS A FEASIBLE METHOD FOR ORAL MICROBIOTA ANALYSIS FOR INFANTS AND MOTHERS.

J Dent 2020 Jul 9:103428. Epub 2020 Jul 9.

Academic Centre for Dentistry Amsterdam (ACTA), Department of Preventive Dentistry, Gustav Mahlerlaan 3004, 1081 LA, Amsterdam, the Netherlands. Electronic address:

Objectives: Large longitudinal cohort studies in infants are needed to understand oral microbiome maturation in relation to general health. The logistics of such studies are complex and costs involved high. Methods like home sampling by caretakers might be a solution to these issues. Read More

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http://dx.doi.org/10.1016/j.jdent.2020.103428DOI Listing

Small core needle biopsies in cytology practice: a survey of members of the American Society of Cytopathology.

J Am Soc Cytopathol 2020 Jun 18. Epub 2020 Jun 18.

Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Department of Pathology and Laboratory Medicine, Madison, Wisconsin.

Introduction: The introduction of a new generation of core needle biopsies (CNBs) for endoscopic procedures has prompted reconsideration of the role of cytopathologists in the handling of small biopsies. The American Society of Cytopathology (ASC) has therefore conducted a survey with the intention of elucidating current practices regarding the handling of small CNBs.

Materials And Methods: The membership of the ASC was invited by email to participate in an online survey over a 2-month period. Read More

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http://dx.doi.org/10.1016/j.jasc.2020.06.002DOI Listing

A Prospective Evaluation of Point-of-Care Ultrasonographic Diagnosis of Diverticulitis in the Emergency Department.

Ann Emerg Med 2020 Jul 8. Epub 2020 Jul 8.

Department of Emergency Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY.

Study Objective: We evaluate the sensitivity and specificity of point-of-care ultrasonography, performed by ultrasonographic fellowship-trained emergency physicians and physician assistants, compared with computed tomography (CT) scan in diagnosing acute diverticulitis in the emergency department (ED).

Methods: This was a prospective observational study of a convenience sample of patients with suspected diverticulitis who were treated at an academic ED between 2017 and 2020. Sonographers were blinded to clinical data, laboratory results, and CT scan findings. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2020.05.017DOI Listing

Personality, emotional and cognitive functions in young adults born preterm.

Brain Dev 2020 Jul 8. Epub 2020 Jul 8.

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy. Electronic address:

Background: Survival of preterm very low birthweight infants resulted in high risk for developmental cognitive deficits, poor academic achievement, and behaviour disorders. While numerous studies evaluated the prevalence of neurodevelopmental disability in early childhood, poor literature is available for infants born very low birthweight in adulthood.

Materials And Methods: Fifty-five young adults born preterm (mean age: 18 ± 2. Read More

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http://dx.doi.org/10.1016/j.braindev.2020.06.014DOI Listing

Association of gallbladder hyperkinesia with acalculous chronic cholecystitis: A case-control study.

Surgery 2020 Jul 8. Epub 2020 Jul 8.

Department of Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA. Electronic address:

Background: This is the first case-control study investigating an association between gallbladder hyperkinesia and symptomatic acalculous chronic cholecystitis.

Methods: This retrospective study in a single academic center compared resolution of biliary pain in adults with gallbladder hyperkinesia, defined as a hepatobiliary iminodiacetic acid scan ejection fraction ≥80%, undergoing cholecystectomy (study group) with those treated medically without cholecystectomy (control group). Of 1,477 hepatobiliary iminodiacetic acid scans done between 2013 and 2018, a total of 296 adults without gallstones had an ejection fraction ≥80%, of whom 46 patients met predetermined eligibility criteria. Read More

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http://dx.doi.org/10.1016/j.surg.2020.06.005DOI Listing

Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22-05): a single-arm, phase 1b-2 trial.

Lancet Oncol 2020 Jul 9. Epub 2020 Jul 9.

Seoul National University College of Medicine, Seoul, South Korea.

Background: Margetuximab, a novel, investigational, Fc-engineered, anti-HER2 monoclonal antibody, is designed to more effectively potentiate innate immunity than trastuzumab. We aimed to evaluate the safety, tolerability, and antitumour activity of margetuximab plus pembrolizumab (an anti-PD-1 monoclonal antibody) in previously treated patients with HER2-positive gastro-oesophageal adenocarcinoma.

Methods: CP-MGAH22-05 was a single-arm, open-label, phase 1b-2 dose-escalation and cohort expansion study done at 11 academic centres in the USA and Canada and 15 centres in southeast Asia (Korea, Taiwan, and Singapore) that enrolled men and women aged 18 years or older with histologically proven, unresectable, locally advanced or metastatic, HER2-positive, PD-L1-unselected gastro-oesophageal adenocarcinoma, with an Eastern Cooperative Oncology Group performance status of 0 or 1, who had progressed after at least one previous line of therapy with trastuzumab plus chemotherapy in the locally advanced unresectable or metastatic setting. Read More

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http://dx.doi.org/10.1016/S1470-2045(20)30326-0DOI Listing

Obsessive compulsive disorder in very young children - a case series from a specialized outpatient clinic.

BMC Psychiatry 2020 Jul 11;20(1):366. Epub 2020 Jul 11.

Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Neumünsterallee 3, 8032, Zurich, Switzerland.

Background: Paediatric obsessive-compulsive disorder (OCD) is a chronic condition often associated with severe disruptions of family functioning, impairment of peer relationships and academic performance. Mean age of onset of juvenile OCD is 10.3 years; however, reports on young children with OCD show that the disorder can manifest itself at an earlier age. Read More

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http://dx.doi.org/10.1186/s12888-020-02780-0DOI Listing

Nucleic acids in inclusion bodies obtained from E. coli cells expressing human interferon-gamma.

Microb Cell Fact 2020 Jul 11;19(1):139. Epub 2020 Jul 11.

Institute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Academic Georgi Bonchev Str., Blok 21, 1113, Sofia, Bulgaria.

Background: Inclusion bodies (IBs) are protein aggregates in recombinant bacterial cells containing mainly the target recombinant protein. Although it has been shown that IBs contain functional proteins along with protein aggregates, their direct application as pharmaceuticals is hindered by their heterogeneity and hazardous contaminants with bacterial origin. Therefore, together with the production of soluble species, IBs remain the main source for manufacture of recombinant proteins with medical application. Read More

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http://dx.doi.org/10.1186/s12934-020-01400-6DOI Listing

Are parents' education levels associated with either their oral health knowledge or their children's oral health behaviors? A survey of 8446 families in Wuhan.

BMC Oral Health 2020 Jul 11;20(1):203. Epub 2020 Jul 11.

Center for Evidence-Based Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Background: Children aged 6-7 years are in the early mixed dentition, which is a period of high prevalence of dental caries and other dental diseases and a critical period for the formation of oral health behaviors. Therefore, good oral hygiene habits of children and oral health knowledge of parents are very important. This study sought to explore the relationship between children's oral health behaviors, parental oral health knowledge, parental choices of pit and fissure sealants, and parents' education levels based on a large-scale sample size for the first time, and to compare the influences of parental education levels between parents. Read More

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http://dx.doi.org/10.1186/s12903-020-01186-4DOI Listing

Whispers, echoes, friends and fears: forms and functions of voice-hearing in adolescence.

Child Adolesc Ment Health 2020 Jul 11. Epub 2020 Jul 11.

Division of Psychology and Mental Health, School of Health Sciences, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.

Background: Despite the high prevalence of voice-hearing in childhood, research with adolescents aged under 16 years is scarce. Theoretical connections between clinical and developmental conceptualizations of voice-hearing are limited, resulting in missed opportunities to explore unusual sensory experiences with young people.

Methods: Demographic, contextual and qualitative data were collected through a web-based survey with 68 adolescents (M = 14. Read More

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http://dx.doi.org/10.1111/camh.12403DOI Listing

Management and outcomes of heart failure patients with CKD: experience from an inter-disciplinary clinic.

ESC Heart Fail 2020 Jul 11. Epub 2020 Jul 11.

Renal and Transplantation Unit, St George's University Hospital NHS Foundation Trust, London, UK.

Aims: CKD-HF patients suffer excess hospitalization and mortality, often under-treated with life-prolonging medications due to fear of worsening renal function and hyperkalaemia. Yet, role of inter-disciplinary working in improving therapy is unknown, which this study aims to investigate.

Methods And Results: Clinical, biochemical data, and medications at first and last clinic visit were obtained from patient records for 124 patients seen in kidney failure-heart failure clinic (23 March 2017 to 11 April 2019). Read More

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http://dx.doi.org/10.1002/ehf2.12796DOI Listing

The Anti-Racist, Pro-patient Pledge of Emergency Medicine.

Acad Emerg Med 2020 Jul 11. Epub 2020 Jul 11.

Medical College of Wisconsin, Hub for Collaborative Medicine, 8701 W Watertown Plank Rd, Milwaukee, WI, 53226, United States.

Recognized as a specialty by the American Board of Medical Specialties over 40 years ago, emergency medicine is unique since its inception-providing care to all patients in all times of unscheduled, time-sensitive need. Members of our specialty-whether working in an academic or private practice setting-provide this care without regard to a patient's sex, sexual orientation, gender, creed, physical ability, ability to pay, or race/ethnicity. The last human determinant of health bears emphasis in our current climate of a race-based inequity crisis. Read More

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http://dx.doi.org/10.1111/acem.14081DOI Listing

Type A aortic dissection in the East and West: A comparative study between two hospitals from China and the US.

J Card Surg 2020 Jul 11. Epub 2020 Jul 11.

Department of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Background: In this study, we compare the clinical characteristics, intraoperative management, and postoperative outcomes of patients with acute type A aortic dissection (ATAAD) between two academic medical hospitals in the United States and China.

Methods: From January 2011 to December 2017, 641 and 150 patients from Nanjing Drum Tower Hospital (NDTH) and Massachusetts General Hospital (MGH) were enrolled. Patient demographics, clinical features, surgical techniques, and postoperative outcomes were compared. Read More

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http://dx.doi.org/10.1111/jocs.14766DOI Listing

The impact of SARS-CoV-2 on surgical education - challenges and potential solutions.

Authors:
J-P St Mart E L Goh

Br J Surg 2020 Jul 11. Epub 2020 Jul 11.

Oxford University Clinical Academic Graduate School, Medical Sciences Division, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1002/bjs.11793DOI Listing

Mental fatigue in stress-related exhaustion disorder: Structural brain correlates, clinical characteristics and relations with cognitive functioning.

Neuroimage Clin 2020 Jul 3;27:102337. Epub 2020 Jul 3.

Umeå Centre for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden; Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; Department of Radiation Sciences, Umeå University, Sweden; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital Bispebjerg, Copenhagen, Denmark.

Emerging evidence suggests that mental fatigue is a central component of the cognitive and clinical characteristics of stress-related exhaustion disorder (ED). Yet, the underlying mechanisms of mental fatigue in this patient group are poorly understood. The aim of this study was to investigate cortical and subcortical structural neural correlates of mental fatigue in patients with ED, and to explore the association between mental fatigue and cognitive functioning. Read More

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http://dx.doi.org/10.1016/j.nicl.2020.102337DOI Listing

Targeting higher levels of lactate in the post-injury period following traumatic brain injury.

Clin Neurol Neurosurg 2020 Jul 2;196:106050. Epub 2020 Jul 2.

State Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine, Department of Neurology, Department of Functional Neurosurgery and Paroxysmal States, Academic Pavlov Str, 46, Kharkiv, 61068, Ukraine. Electronic address:

Background: Secondary traumatic brain injury (TBI) consequences continue multiple cascades of biochemical reactions caused by initial neurotrauma and one of the important pathogenetic processes is mitochondrial dysfunction partly characterized by elevation of lactate/pyruvate ratio in brain following metabolic failure.

Objective: To identify lactate, pyruvate, lactate dehydrogenase, tau protein, ceruloplasmin blood levels in the post-injury period following TBI in relation to its different forms.

Patients And Methods: Ninety-six patients (mean age ± SD 38. Read More

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http://dx.doi.org/10.1016/j.clineuro.2020.106050DOI Listing

Ref: NET_2019_1563: Working while studying: The impact of term-time employment on undergraduate nursing students' engagement in the Republic of Ireland: A cross-sectional study.

Nurse Educ Today 2020 Jun 26;92:104513. Epub 2020 Jun 26.

School of Nursing, Midwifery and Health Systems, Health, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address:

Background: Globally, there is evidence that tertiary education students are increasingly combining full time study with paid term-time employment. Despite this dual participation, little is known about the impact of working for pay during term on students' engagement with activities, both academic and social, that are associated with learning and development.

Objectives: To measure undergraduate nursing students' term-time employment commitments and the impact of those commitments on nursing students' engagement. Read More

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http://dx.doi.org/10.1016/j.nedt.2020.104513DOI Listing

Undergraduate nursing program admission criteria: A scoping review of the literature.

Nurse Educ Today 2020 Jul 2;92:104519. Epub 2020 Jul 2.

Georgia Baptist College of Nursing, Mercer University, United States of America.

Objective: To provide a broad overview of literature related to undergraduate nursing program admission criteria used by faculty and administrators in the United States to predict student program success.

Design: A scoping review of literature.

Review Methods: Review was guided by the framework for a scoping review suggested by Arksey and O'Malley (2007). Read More

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http://dx.doi.org/10.1016/j.nedt.2020.104519DOI Listing

Steroids receptors immunohistochemical expression in different sites of endometriosis.

J Gynecol Obstet Hum Reprod 2020 Jul 8:101861. Epub 2020 Jul 8.

Department of Integrated Surgical and Diagnostic Sciences (DISC), University of Genova, Genova, Italy; Academic Unit of Pathology, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Background: A better characterization of steroid intracrine pathways in endometriosis lesions may lead to a better understanding of the pathogenesis of the disease and insights on the mechanism of resistance to medical therapy. The study aims to evaluate the expression of steroid receptors in endometriosis lesions, including for the first-time androgen receptors, both in glandular and stromal tissue, and to describe the differences, in any, in receptor expression in the different subtypes.

Basic Procedures: This is a retrospective analysis of 76 specimens from 51 women, that underwent laparoscopic surgery for endometriosis at a tertiary hospital between 2015 and 2019. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101861DOI Listing

Stabilization of an intermolecular RNA triplex by two novel binders Lys- and Arg-rich Ru(II) polypyridyl metallopeptides.

J Inorg Biochem 2020 Jul 3;210:111171. Epub 2020 Jul 3.

Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China; Key Laboratory for Green Organic Synthesis and Application of Hunan Province, Xiangtan University, Xiangtan 411105, People's Republic of China. Electronic address:

In this work, using [Ru(bpy)(pip)] (bpy = 2,2'-bipyridine, pip = 2-phenyl-1H-imidazo[4,5-f]-[1,10]-phenanthroline) as chromophores and neutral amino acid glycine as spacers, two novel Arg- and Lys-rich Ru(II) polypyridyl metallopeptides as an intermolecular triplex RNA stabilizers, namely [Ru(bpy)(pic-Lys-Gly-Lys-Gly-Lys)] (Ru1; pic = 2-(4-carboxy-phenyl)imidazo-[4,5-f] [1,10] phenanthroline, Gly = glycine, Lys = lysine) and [Ru(bpy)(pic-Arg-Gly-Arg-Gly-Arg)] (Ru2; Arg = arginine), have been synthesized and characterized. The binding properties of Ru1 and Ru2 with poly(U)·poly(A)∗poly(U) triplex have been studied by UV-Vis spectroscopy, fluorescence spectroscopy, viscosity measurements as well as circular dichroism and thermal denaturation. The obtained results suggest that attaching cationic peptides to a Ru(II) polypyridyl complex can obviously enhance the triplex stabilization. Read More

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http://dx.doi.org/10.1016/j.jinorgbio.2020.111171DOI Listing

Operationalizing an Academic Pediatric Practice during the COVID-19 Crisis.

Am J Infect Control 2020 Jul 8. Epub 2020 Jul 8.

Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania.

We report on innovating protocols at an Academic Pediatric practice during the COVID-19 (2019 novel coronavirus) crisis. Facing the challenges of limited personal protective equipment and testing capacity, we rapidly and efficiently changed processes to optimize infection control, providing safe and effective care for our vulnerable population. Read More

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http://dx.doi.org/10.1016/j.ajic.2020.07.003DOI Listing

Postoperative urinary retention following benign gynecologic surgery with a liberal vs. strict voiding protocol.

J Minim Invasive Gynecol 2020 Jul 8. Epub 2020 Jul 8.

Cedars-Sinai Department of Obstetrics & Gynecology. Los Angeles, CA.

Study Objective: Surgeons employ various methods for evaluating what is considered a common occurrence after gynecologic operations, postoperative urinary retention (POUR). Few have reported the incidence of POUR with a liberal voiding protocol (no requirement to void prior to discharge). The primary objective of this study is to evaluate the risk of POUR after benign gynecologic surgery, comparing a liberal voiding protocol to more strict voiding protocols. Read More

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http://dx.doi.org/10.1016/j.jmig.2020.07.002DOI Listing

Reframing High-Quality Public Preschool as a Vehicle for Narrowing Child Health Disparities Based on Family Income.

Acad Pediatr 2020 Jul 8. Epub 2020 Jul 8.

Early Childhood Education Institute, University of Oklahoma - Tulsa, 4502 E. 41(st) Street, Room 4W-123, Tulsa, OK 74135, (918) 660-3187. Electronic address:

Past research shows that high-quality public preschool may disproportionately support low-income children's school readiness, because low-income children tend to arrive at school with fewer of the academic skills needed for success. This suggests a compensatory process in human development in which the children who benefit most from a promotive factor are those who stand to gain the most. We propose that high-quality public preschool may similarly confer its greatest health rewards to low-income children, who are generally in poorer health than their peers. Read More

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http://dx.doi.org/10.1016/j.acap.2020.07.004DOI Listing

The Dual PDZ Domain from Postsynaptic Density Protein 95 Forms a Scaffold with Peptide Ligand.

Biophys J 2020 Jun 26. Epub 2020 Jun 26.

School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom. Electronic address:

PSD-95 is a member of the membrane-associated guanylate kinase class of proteins that forms scaffolding interactions with partner proteins, including ion and receptor channels. PSD-95 is directly implicated in modulating the electrical responses of excitable cells. The first two PSD-95/disks large/zona occludens (PDZ) domains of PSD-95 have been shown to be the key component in the formation of channel clusters. Read More

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http://dx.doi.org/10.1016/j.bpj.2020.06.018DOI Listing

A Genomewide Pharmacogenetic Study of Growth Hormone Responsiveness.

J Clin Endocrinol Metab 2020 Jul 11. Epub 2020 Jul 11.

Division of Endocrinology, Boston Children's Hospital, and Program in Medical and Population Genetics, Broad Institute, Harvard Medical School, Boston, MA, United States.

Context: Individual patients vary in their response to growth hormone (GH). No large scale genomewide studies have looked for genetic predictors of GH responsiveness.

Objective: To identify genetic variants associated with GH responsiveness. Read More

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http://dx.doi.org/10.1210/clinem/dgaa443DOI Listing

The role played by traditional Chinese medicine in preventing and treating COVID-19 in China.

Front Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100056, China.

Traditional Chinese medicine (TCM), an ancient system of alternative medicine, played an active role in the prevention and control of COVID-19 in China. It improved the clinical symptoms of patients, reduced the mortality rate, improved the recovery rate, and effectively relieved the operating pressure on the national medical system during critical conditions. In light of the current global pandemic, TCM-related measures might open up a new channel in the control of COVID-19 in other countries and regions. Read More

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http://dx.doi.org/10.1007/s11684-020-0801-xDOI Listing

Guidance for Healthcare Providers Managing COVID-19 in Rural and Underserved Areas.

J Racial Ethn Health Disparities 2020 Jul 10. Epub 2020 Jul 10.

Department of Medicine, West Virginia University, PO Box 9156, Morgantown, WV, 26506, USA.

Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has ravaged many urban and high-density areas in the USA. However, rural areas (despite their low population density) may be especially vulnerable to poor outcomes from COVID-19, owing to limited healthcare infrastructure, long distances to advanced health care, and population characteristics (e.g. Read More

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http://dx.doi.org/10.1007/s40615-020-00820-9DOI Listing

Separation of mono- and di-valent ions from seawater reverse osmosis brine using selective electrodialysis.

Environ Sci Pollut Res Int 2020 Jul 10. Epub 2020 Jul 10.

Engineering Research Center of Resource Process Engineering, Ministry of Education, Shanghai, China.

As water scarcity has become a serious global issue, seawater reverse osmosis (SWRO) is considered as a promising technique to expand traditional water supplies. However, the reject brine from SWRO systems is still a major environmental concern. In this research, the monovalent selective electrodialysis (S-ED) was used to separate and recover one of the primary components, i. Read More

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http://dx.doi.org/10.1007/s11356-020-10014-9DOI Listing

Radiological outpatient' visits to avoid inappropriate cardiac CT examinations: an 8-year experience report.

Radiol Med 2020 Jul 10. Epub 2020 Jul 10.

Department of Radiological, Oncological and Pathological Sciences, "Sapienza" University of Rome, V.le Regina Elena, 324 00161, Rome, Italy.

Purpose: The aim of this study was to evaluate the appropriateness of the cardiac computed tomography angiography (CCTA) prescriptions according to the "2010-Appropriate-Use-Criteria-for-Cardiac-Computed-Tomography-Angiography" (AUCCTA) and "Clinical-indication-for-CCTA" (CICCTA) among different specialities (Cardiologist [CA], General Practitioner [GP], Other Specialists [OS]) and prescribers' age.

Materials And Methods: This is a single-centre, single-arm, cohort study. We prospectively enrolled 815 patients (October 2012-May 2019) who underwent a radiological outpatient visit, before CCTA examination. Read More

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http://dx.doi.org/10.1007/s11547-020-01246-3DOI Listing

Morgagni and Boerhaave in 1719 : The European academic network in the 18th century demonstrated by a letter from Giovanni Battista Morgagni.

Wien Med Wochenschr 2020 Jul 10. Epub 2020 Jul 10.

Sigmund Freud University Vienna & Hospital of the Sisters of Charity, Vienna, Austria.

The European academic network in 18th century Europe and the interaction between two eminent 18th century scientists is illustrated by a recently recovered letter from 25.IX.1719 by Giovanni Battista Morgagni (1682-1771). Read More

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http://dx.doi.org/10.1007/s10354-020-00764-zDOI Listing

Hormonal Evaluation of Incidental Adrenal Masses: The Exception, Not the Rule.

World J Surg 2020 Jul 10. Epub 2020 Jul 10.

Division of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, N924 Doan Hall, 410 W. 10th Avenue, Columbus, OH, 43210, USA.

Background: Incidental adrenal masses (IAMs) occur in approximately 4% of patients undergoing abdominal CT scans for any indication. Hormonal evaluation is recommended for all IAMs. The purpose of this study was to identify the rate of IAMs in a screening population and to determine the adequacy of endocrine evaluation of newly identified IAMs based on established guidelines. Read More

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http://dx.doi.org/10.1007/s00268-020-05679-9DOI Listing

Nurse workarounds in the electronic health record: An integrative review.

J Am Med Inform Assoc 2020 Jul 11. Epub 2020 Jul 11.

Center for Nursing Classification & Clinical Effectiveness, College of Nursing, The University of Iowa, Iowa City, Iowa, USA.

Objective: The study sought to synthesize published literature on direct care nurses' use of workarounds related to the electronic health record.

Materials And Methods: We conducted an integrative review of qualitative and quantitative peer-reviewed research through a structured search of Academic Search Complete, EBSCO Cumulative Index of Nursing and Allied Health Literature (CINAHL), Embase, Engineering Village, Ovid Medline, Scopus, and Web of Science. We systematically applied exclusion rules at the title, abstract, and full article stages and extracted and synthesized their research methods, workaround classifications, and probable causes from articles meeting inclusion criteria. Read More

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http://dx.doi.org/10.1093/jamia/ocaa050DOI Listing

Epidural Anesthesia in Liver Surgery-A Propensity Score-Matched Analysis.

Pain Med 2020 Jul 11. Epub 2020 Jul 11.

Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Objective: To assess the effects of epidural anesthesia (EA) on patients who underwent liver resection.

Design: Secondary analysis of a prospective randomized controlled trial.

Setting: This single-center study was conducted at an academic medical center. Read More

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http://dx.doi.org/10.1093/pm/pnaa130DOI Listing

Transforming ophthalmic education into virtual learning during COVID-19 pandemic: a global perspective.

Eye (Lond) 2020 Jul 10. Epub 2020 Jul 10.

Division of Ophthalmology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

Objective: The coronavirus disease 2019 (COVID-19) pandemic has imposed measures of social distancing and barriers in delivery of "in person" education. Institutions, involved in training the next generation of ophthalmologists, are using alternative teaching methods to maintain the standard of education.

Methods: We conducted a worldwide survey among physicians, who are actively involved in Ophthalmology-related education, between 3 and 14 April 2020. Read More

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http://dx.doi.org/10.1038/s41433-020-1080-0DOI Listing

Helicobacter pylori patient isolates from South Africa and Nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome.

Sci Rep 2020 Jul 10;10(1):11409. Epub 2020 Jul 10.

Chair of Medical Microbiology and Hospital Epidemiology, Max von Pettenkofer-Institute, Faculty of Medicine, LMU Munich, Munich, Germany.

Helicobacter pylori is a gram-negative, spiral-shaped bacterial pathogen and the causative agent for gastritis, peptic ulcer disease and classified as a WHO class I carcinogen. While the prevalence of H. pylori infections in Africa is among the highest in the world, the incidence of gastric cancer is comparably low. Read More

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http://dx.doi.org/10.1038/s41598-020-66128-0DOI Listing