Acad Radiol 2017 Nov 23. Epub 2017 Nov 23.
Department of Medical Physics, University of Wisconsin-Madison, 1111 Highland Ave, Madison, WI 53705; Department of Biomedical Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison, WI 53706; Department of Radiology, University of Wisconsin-Madison, 600 Highland Ave, Madison, WI 53792. Electronic address:
Rationale And Objectives
: To determine lobar ventilation patterns in asthmatic lungs with hyperpolarized 3He magnetic resonance imaging (HP 3He MRI).Materials And Methods
: Eighty-two subjects (14 normal, 48 mild-to-moderate asthma, and 20 severe asthma) underwent HP 3He MRI, computed tomography (CT), and pulmonary function testing. After registering proton to 3He images, we segmented the lungs from proton MRI and further segmented the five lung lobes (right upper lobe [RUL], right middle lobe [RML], and right lower lobe [RLL]; left upper lobe and left lower lobe [LLL]) by referring to the lobar segmentation from CT. Read More