205,200 results match your criteria Academic Physician & Scientist[Journal]


Novel endotypes in heart failure: effects on guideline-directed medical therapy.

Eur Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.

Aims: We sought to determine subtypes of patients with heart failure (HF) with a distinct clinical profile and treatment response, using a wide range of biomarkers from various pathophysiological domains.

Methods And Results: We performed unsupervised cluster analysis using 92 established cardiovascular biomarkers to identify mutually exclusive subgroups (endotypes) of 1802 patients with HF and reduced ejection fraction (HFrEF) from the BIOSTAT-CHF project. We validated our findings in an independent cohort of 813 patients. Read More

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December 2018

Appropriate use criteria adoption for PCI at an academic medical center.

Eur Heart J 2018 Dec;39(47):4136-4138

Division of Cardiovascular Medicine, Department of Medicine, Case Western Reserve University School of Medicine, 11100 Euclid Ave, Mailstop LKS 5038, Cleveland, Ohio, Phone: (216) 844-7760, Fax: (216) 844-8954.

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December 2018

Fourteen-year trajectories of posttraumatic stress disorder (PTSD) symptoms in UK military personnel, and associated risk factors.

J Psychiatr Res 2018 Nov 30;109:156-163. Epub 2018 Nov 30.

King's Centre for Military Health Research, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Electronic address:

The aim of this study was to examine trajectories of posttraumatic stress disorder (PTSD) symptoms over a 14-year period and the risk factors associated with each trajectory. 1885 UK military personnel provided information at four time points since 2002. The PTSD Check list-Civilian Version (PCL-C) was used at all time points. Read More

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November 2018

Correlation of different cellular assays to analyze T cell-related cytokine profiles in vitamin D-supplemented patients with multiple sclerosis.

Mol Immunol 2018 Dec 11;105:198-204. Epub 2018 Dec 11.

Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address:

Different laboratory approaches have been exploited to analyze an effect of vitamin D supplements on T cell cytokine profiles in multiple sclerosis, with poorly reproducible results. We assessed the correlation between intra-cellular flowcytometry analysis of CD4 T cell-enriched CD3CD8 lymphocytes after PMA/ionomycin stimulation directly ex-vivo or after 72 h pre-stimulation with anti-CD3, and cytokine levels excreted in culture supernatants. Pre-stimulation with anti-CD3 resulted in higher proportions of cells positive for IFN-γ, IL-17 A, IL-4, IL-10 and GM-CSF (all P < 0. Read More

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December 2018

Identification of B cell epitopes enhanced by protein unfolding and aggregation.

Mol Immunol 2018 Dec 11;105:181-189. Epub 2018 Dec 11.

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, UK. Electronic address:

Aggregation of therapeutic proteins is a key factor in the generation of unwanted immunogenicity, and can result in reduced serum half-life, neutralization of function and adverse health effects. There is currently little information regarding how aggregates interact with B-cell receptors or cognate antibodies at the protein sequence level, or whether non-native, aggregate-induced epitopes predominate in these interactions. Using an antibody fragment (single chain antibody variable fragment; scFv) that forms aggregates readily at low temperature, anti-scFv IgG antibody responses were generated by intraperitoneal injection of BALB/c strain mice with monomer or aggregate preparations. Read More

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December 2018
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Clinico-pathological characteristics among South African women with breast cancer receiving anti-retroviral therapy for HIV.

Breast 2018 Dec 7;43:123-129. Epub 2018 Dec 7.

Non-Communicable Diseases Research Division, Wits Health Consortium (PTY) Ltd, 31 Princess of Wales Building, Johannesburg, 2193, South Africa; Department of Medicine, University of Witwatersrand Faculty of Health Sciences, 7 York Road Johannesburg, South Africa.

Purpose: Breast cancer is the most common cancer in women and a leading cause of cancer-related mortality worldwide. South Africa has the largest global burden of HIV infection and the largest anti-retroviral treatment (ART) program. This study aimed to analyse the association of HIV and ART use with breast cancer clinico-pathological characteristics. Read More

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December 2018

Predicting drug-target interactions using Lasso with random forest based on evolutionary information and chemical structure.

Genomics 2018 Dec 11. Epub 2018 Dec 11.

College of Mathematics and Physics, Qingdao University of Science and Technology, Qingdao 266061, China; Artificial Intelligence and Biomedical Big Data Research Center, Qingdao University of Science and Technology, Qingdao 266061, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China. Electronic address:

The identification of drug-target interactions has great significance for pharmaceutical scientific research. Since traditional experimental methods identifying drug-target interactions is costly and time-consuming, the use of machine learning methods to predict potential drug-target interactions has attracted widespread attention. This paper presents a novel drug-target interactions prediction method called LRF-DTIs. Read More

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December 2018

The Asthma Controller Step-down Yardstick.

Ann Allergy Asthma Immunol 2018 Dec 11. Epub 2018 Dec 11.

Kaiser Permanente Southern California Region, Department of Allergy and Research and Evaluation, San Diego and Pasadena, CA.

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December 2018
2 Reads

Bayesian hierarchical vector autoregressive models for patient-level predictive modeling.

PLoS One 2018 14;13(12):e0208082. Epub 2018 Dec 14.

Department of Statistics, Columbia University, New York, NY, United States of America.

Predicting health outcomes from longitudinal health histories is of central importance to healthcare. Observational healthcare databases such as patient diary databases provide a rich resource for patient-level predictive modeling. In this paper, we propose a Bayesian hierarchical vector autoregressive (VAR) model to predict medical and psychological conditions using multivariate time series data. Read More

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December 2018

Effects of Intimate Partner Violence and Home Environment on Child Language Development in the First 3 Years of Life.

J Dev Behav Pediatr 2018 Dec 13. Epub 2018 Dec 13.

Department of Pediatrics, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH.

Objective: Intimate partner violence (IPV) can adversely affect children's cognitive development, but links between IPV exposure and language development in the earliest years of life remain unknown. The present study examined the effects of IPV and the quality of the home environment on children's language development at age 3 years.

Methods: In a prospective, 5-panel, longitudinal study of 79 mother-child dyads assessed prenatally to age 3 years, we examined standardized measures of receptive and expressive language development at age 3 years. Read More

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December 2018
1 Read

Fit4SurgeryTV at-home prehabilitation for frail elderly planned for colorectal cancer surgery: a pilot study.

Am J Phys Med Rehabil 2018 Dec 13. Epub 2018 Dec 13.

Department of surgery, Academic Medical Center, Amsterdam, The Netherlands.

Objective: The preoperative phase is a potential window of opportunity. Although frail elderly patients are known to be more prone to postoperative complications, they are often not considered capable of accomplishing a full prehabilitation program. The aim of this study was to assess the feasibility of Fit4SurgeryTV, an at-home prehabilitation program specifically designed for frail elderly with colorectal cancer (CRC). Read More

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December 2018

Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.

Anesthesiology 2019 Jan;130(1):41-54

From The North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States, University of Pittsburgh Medical Center, Mercy Hospital, Pittsburgh, Pennsylvania (2000 through 2017; M.G.L., B.W.B.) Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida (2018; M.G.L.) Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan (T.T.K., M.T.V., S.K.) Department of Nurse Anesthesia, University of Pittsburgh, Pittsburgh, Pennsylvania (2016 through 2018; B.W.B.) Department of Anesthesiology, School of Medicine (K.G.B., T.W.K., J.C.) School of Public Health (K.G.B.), University of Minnesota, Minneapolis, Minnesota Department of Anesthesiology, Children's Hospital of Pittsburgh (E.L.S.) Department of Anesthesiology (A.H.), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania Department of Anesthesiology, Weill Cornell Medical College and New York-Presbyterian Hospital, New York, New York (J.L.) Department of Anesthesia and Pain Management, University Health Network, University of Toronto, Toronto, Canada (S.R.) Department of Anesthesiology and Pediatrics, Emory University School of Medicine, and Children's Healthcare of Atlanta, Egleston Hospital, Atlanta, Georgia (D.M.). Current positions: Dr. Larach is now at the Department of Anesthesiology, University of Florida, Gainesville, Florida. Dr. Sivak is now at the Department of Anesthesiology and Pain Medicine, Nationwide Children's Hospital and The Ohio State University, Columbus, Ohio. Department of Anesthesiology, Academic Medical Center, Amsterdam, The Netherlands Beaumont Health, Dearborn, Michigan Beaumont Health, Royal Oak, Michigan Beaumont Health, Farmington Hills, Michigan Beaumont Health, Grosse Pointe, Michigan Bronson Healthcare, Battle Creek, Michigan Bronson Healthcare, Kalamazoo, Michigan CHOC Children's Hospital, Orange, California Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio Department of Anesthesiology, Columbia University Medical Center, New York, New York Henry Ford Health System, Detroit, Michigan Henry Ford Health System, West Bloomfield, Michigan Holland Hospital, Holland, Michigan Mercy Health, Muskegon, Michigan Department of Anesthesiology and Critical Care Medicine, Memorial Sloan Kettering Cancer Center, New York, New York Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University Langone Medical Center, New York, New York Department of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, Oregon St. Joseph Mercy, Ann Arbor, Michigan St. Joseph Mercy Oakland, Pontiac, Michigan St. Mary Mercy Hospital, Livonia, Michigan Sparrow Health System, Lansing, Michigan Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, California Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands Department of Anesthesiology, University of Colorado, Aurora, Colorado Department of Anesthesiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma Department of Anesthesiology, University of Pennsylvania, Philadelphia, Pennsylvania Department of Anesthesiology, University of Tennessee Medical Center, Knoxville, Tennessee Department of Anesthesiology, University of Utah, Salt Lake City, Utah Department of Anesthesiology, University of Vermont, Larner College of Medicine, Burlington, Vermont Department of Anesthesiology, University of Virginia, Charlottesville, Virginia Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee Department of Anesthesiology, Wake Forest Baptist Health, Winston-Salem, North Carolina Department of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri Department of Anesthesiology, Weill Cornell Medical College, New York, New York Department of Anesthesiology, Yale School of Medicine, New Haven, Connecticut.

What We Already Know About This Topic: WHAT THIS ARTICLE TELLS US THAT IS NEW: BACKGROUND:: Although dantrolene effectively treats malignant hyperthermia (MH), discrepant recommendations exist concerning dantrolene availability. Whereas Malignant Hyperthermia Association of the United States guidelines state dantrolene must be available within 10 min of the decision to treat MH wherever volatile anesthetics or succinylcholine are administered, a Society for Ambulatory Anesthesia protocol permits Class B ambulatory facilities to stock succinylcholine for airway rescue without dantrolene. The authors investigated (1) succinylcholine use rates, including for airway rescue, in anesthetizing/sedating locations; (2) whether succinylcholine without volatile anesthetics triggers MH warranting dantrolene; and (3) the relationship between dantrolene administration and MH morbidity/mortality. Read More

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January 2019

Impact of Fentanyl Use on Buprenorphine Treatment Retention and Opioid Abstinence.

J Addict Med 2018 Dec 13. Epub 2018 Dec 13.

Division of General Internal Medicine, Massachusetts General Hospital (SEW, YC, SR, LY, JM, NR); Harvard Medical School (SEW, YC, SR, JF, JM, NR); Department of Pathology, Massachusetts General Hospital, Boston, MA (JF).

Objectives: There has been a rapid increase in the presence of illicitly manufactured fentanyl in the heroin drug supply. Buprenorphine is an effective treatment for heroin and prescription opioid use disorder; however, little is known about treatment outcomes among people using fentanyl. We compared 6-month treatment retention and opioid abstinence among people initiating buprenorphine treatment who had toxicology positive for heroin compared to fentanyl at baseline. Read More

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December 2018

Hypogonadotropic hypogonadism and pituitary hypoplasia as recurrent features in Ulnar-Mammary syndrome.

Endocr Connect 2018 Dec;7(12):1432-1441

IRCCS Istituto Auxologico Italiano, Service of Medical Genetics, Milan, Italy.

Ulnar-mammary syndrome (UMS) is characterized by ulnar defects, and nipple or apocrine gland hypoplasia, caused by TBX3 haploinsufficiency. Signs of hypogonadism were repeatedly reported, but the mechanisms remain elusive. We aim to assess the origin of hypogonadism in two families with UMS. Read More

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December 2018

"Same but different": Associations between multiple aspects of self-regulation, cognition, and academic abilities.

J Pers Soc Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

Self-regulation describes the ability to control both behaviors and internal states against a backdrop of conflicting or distracting situations, drives, or impulses. In the cognitive psychology tradition, individual differences in self-regulation are commonly measured with performance-based tests of executive functioning, whereas in the personality psychology tradition, individual differences in self-regulation are typically assessed with report-based measures of impulse control, sustained motivation, and perseverance. The goal of this project was (a) to comprehensively examine the structure of associations between multiple self-regulatory constructs stemming from the cognitive and personality psychology traditions; (b) to estimate how these constructs, individually and collectively, related to mathematics and reading ability beyond psychometric measures of processing speed and fluid intelligence; and (c) to estimate the extent to which genetic and environmental factors mediated the observed associations. Read More

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December 2018
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The role of academic status norms in friendship selection and influence processes related to academic achievement.

Dev Psychol 2018 Dec 13. Epub 2018 Dec 13.

Department of Interdisciplinary Social Sciences, Utrecht University.

This study examined the role of academic status norms in friendship selection and influence processes related to academic achievement across the 2nd year of secondary school (SNARE project; N = 1,549 students from 70 classes; M = 13.69 years). Academic status norms were operationalized as the class-level correlation between academic achievement and 4 types of peer status: popularity, acceptance, unpopularity, and rejection. Read More

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December 2018

[The 50 most cited articles in orthopedics and traumatology by Mexican authors].

Acta Ortop Mex 2018 Jul-Aug;32(4):214-224

Departamento de Ortopedia. Centro Médico ABC, Ciudad de México, México.

Background: The amount of quotation a scientific article receives is important for the academic impact. In the present study, we analyzed the 50 most cited articles in orthopedics and related areas published by mexican authors, as well as analyzing their main characteristics.

Material And Methods: A search was conducted using Web of Science, of the 50 articles with the largest number of quotation on orthopedics and related areas, in which the principal author or corresponding author had an address in Mexico. Read More

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December 2018

Mogens Schou (1918-2005): a scientist, a doctor and a lithium champion.

Bipolar Disord 2018 Dec 14. Epub 2018 Dec 14.

Aalborg University Hospital, Psychiatry, Aalborg, Denmark.

In November this year, we marked the 100th anniversary of the birthday of Mogens Schou, the great Danish clinical and basic scientist and a true giant of lithium research and treatment. Mogens Schou did more than anybody else in the world to establish lithium therapy, and without his assiduousness lithium may well have been forgotten. To commemorate his achievements a special symposium was organized in Copenhagen dedicated to lithium and the life time contributions of Mogens Schou. Read More

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December 2018
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Impact of high- versus low-risk genotype on sinonasal radiographic disease in cystic fibrosis.

Laryngoscope 2018 Dec 14. Epub 2018 Dec 14.

Department of Otolaryngology Head and Neck Surgery, Johns Hopkins Hospital, Baltimore, Maryland, U.S.A.

Objective: Understanding of how specific mutations impact the cystic fibrosis transmembrane conductance regulator (CFTR) protein has given rise to the classification of CF patients into low-risk and high-risk genotypes. Few prior studies have investigated differences in sinonasal disease between low-risk and high-risk CF genotypes. This multi-institutional review aimed to evaluate radiographic sinus disease severity based on genotype. Read More

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December 2018

Climate change impact and adaptation for wheat protein.

Glob Chang Biol 2019 Jan 22;25(1):155-173. Epub 2018 Nov 22.

Institute of Crop Science and Resource Conservation INRES, University of Bonn, Bonn, Germany.

Wheat grain protein concentration is an important determinant of wheat quality for human nutrition that is often overlooked in efforts to improve crop production. We tested and applied a 32-multi-model ensemble to simulate global wheat yield and quality in a changing climate. Potential benefits of elevated atmospheric CO concentration by 2050 on global wheat grain and protein yield are likely to be negated by impacts from rising temperature and changes in rainfall, but with considerable disparities between regions. Read More

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January 2019
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Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity.

Hum Brain Mapp 2018 Dec 13. Epub 2018 Dec 13.

Gillberg Neuropsychiatry Centre (GNC), University of Gothenburg, Gothenburg, Sweden.

Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. Read More

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December 2018
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Study Enrollment when "Pre-Consent" is Utilized for a Randomized Trial of Two Treatments for Acute Agitation in the Emergency Department.

Acad Emerg Med 2018 Dec 13. Epub 2018 Dec 13.

Department of Emergency Medicine, University of Arkansas for Medical Sciences, Little Rock, AR.

Background: Acute agitation in the ED represents a danger to both patients and their caregivers. Medication is often needed, and few high-quality randomized trials have evaluated the optimal drugs for this vulnerable population. In the United States, as of 2017, randomized trials of drugs cannot be conducted under Waiver of Consent (46 CFR 45. Read More

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December 2018

Ileoanal Pouch Excision - a video vignette.

Colorectal Dis 2018 Dec 13. Epub 2018 Dec 13.

St Mark's Hospital and Academic Institute, London North West Healthcare NHS Trust, Middlesex, HA1 3UJ, UK.

We are now entering the fifth decade of ileoanal pouch surgery. Not surprisingly, this means there is a growing cohort of patients who are suffering pouch failure (roughly 10% at 10 years). For patients in whom an ileostomy alone is inadequate or inappropriate, pouch excision is required. Read More

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December 2018

Revisiting the Optimal Nano-Morphology: Towards Amorphous Organic Photovoltaics.

Chem Rec 2018 Dec 13. Epub 2018 Dec 13.

Department of Chemistry and Chemical Engineering, Royal Military College of Canada, Kingston, ON, Canada, K7K 7B4.

Organic photovoltaic cells commonly use an active layer with a polycrystalline bulk heterojunction. However, for simplifying the fabrication process, it may be worthwhile to use an amorphous active layer to lessen the burden on processing to achieve optimal performance. While polymers can adopt amorphous phases, molecular glasses, small molecules that can readily form glassy phases and do not crystallize over time, offer an appealing alternative, being monodisperse species. Read More

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December 2018

Trends in Female Leadership at High-Profile Otolaryngology Journals, 1997-2017.

Laryngoscope 2018 Dec 13. Epub 2018 Dec 13.

Department of Otolaryngology-Head and Neck Surgery, University of Washington School of Medicine, Seattle, Washington.

Objectives: To determine the proportion and relative advancement of women in leadership positions at high-impact otolaryngology journals.

Methods: Nine clinical otolaryngology journals were selected based on high impact factor and subspecialty representation (journal impact factor, 2016: 1.16-2. Read More

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December 2018

Childhood disintegrative disorder and autism spectrum disorder: a systematic review.

Dev Med Child Neurol 2018 Dec 13. Epub 2018 Dec 13.

Children's Neurosciences, Evelina London Children's Hospital, St Thomas' Hospital, King's Health Partners Academic Health Science Centre, London, UK.

Aim: In an attempt to clarify the debate surrounding the diagnostic validity of childhood disintegrative disorder (CDD), we systematically reviewed its characteristics and compared it with autism spectrum disorder (ASD).

Method: Four databases were searched (PubMed, PsycINFO, Embase, and Web of Science). Included articles had participants with CDD, as defined by symptoms present in the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision and the International Classification of Diseases, 10th Revision. Read More

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December 2018

High-risk behaviours, and their associations with mental health, adherence to antiretroviral therapy and HIV parameters, in HIV-positive men who have sex with men.

HIV Med 2018 Dec 12. Epub 2018 Dec 12.

University College London, London, UK.

Objectives: To investigate the patterns and frequency of multiple risk behaviours (alcohol, drugs, smoking, higher risk sexual activity) among men who have sex with men (MSM) living with HIV.

Methods: Cross sectional study.

Results: 819 HIV-positive MSM exhibited a high-risk phenotype (defined as >3 of smoking, excess alcohol, sexually transmitted infection and recent recreational drug use). Read More

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December 2018

Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review.

J Cosmet Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Botulinum Toxin Type A is a potent neurotoxin that is produced by a gram-positive bacteria clostridium botulinum. Its utilization in the treatment of various medical condition has expanded over the years in both medical and esthetic uses. It is being preferred by most physicians due to its efficacy and lack of side effects. Read More

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December 2018

Applications of Metal-Organic-Framework-Derived Carbon Materials.

Adv Mater 2018 Dec 13:e1804740. Epub 2018 Dec 13.

School of Chemistry and Chemical Engineering, Institute for Innovative Materials and Energy, Yangzhou University, Yangzhou, 225009, Jiangsu, P. R. China.

Carbon materials derived from metal-organic frameworks (MOFs) have attracted much attention in the field of scientific research in recent years because of their advantages of excellent electron conductivity, high porosity, and diverse applications. Tremendous efforts are devoted to improving their chemical and physical properties, including optimizing the morphology and structure of the carbon materials, compositing them with other materials, and so on. Here, many kinds of carbon materials derived from metal-organic frameworks are introduced with a particular focus on their promising applications in batteries (lithium-ion batteries, lithium-sulfur batteries, and sodium-ion batteries), supercapacitors (metal oxide/carbon and metal sulfide/carbon), electrocatalytic reactions (oxygen reduction reaction, oxygen evolution reaction, and hydrogen evolution reaction), water treatment (MOF-derived carbon and other techniques), and other possible fields. Read More

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December 2018

Clinical and molecular characteristics of bladder urothelial carcinoma subtypes.

J Cell Biochem 2018 Dec 12. Epub 2018 Dec 12.

Department of Organization, General Hospital of Benxi Iron and Steel Co., Benxi, China.

Bladder urothelial carcinoma (BLCA) is a common malignancy with high heterogeneity. A reasonable molecular subtyping can facilitate biological study and personalized therapy of BLCA. In this study, unsupervised consensus clustering was used to acquire the molecular subtypes of BLCA based on messenger RNA (mRNA) and microRNA (miRNA) data. Read More

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December 2018
2 Reads

Geriatric Assessment in Older Adults with Multiple Myeloma.

J Am Geriatr Soc 2018 Dec 13. Epub 2018 Dec 13.

Division of Public Health Sciences, Washington University School of Medicine, St Louis, Missouri.

Background/objectives: The incidence of myeloma in older adults is increasing, yet little is known about geriatric impairments in these patients. We aimed to examine the prevalence of geriatric impairments in older adults with myeloma and the association between geriatric assessment and autologous stem cell transplant eligibility.

Design: Prospective cohort study. Read More

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December 2018

Radical vs conservative treatment of intraosseous ameloblastoma: systematic review and meta-analysis.

Oral Dis 2018 Dec 12. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam Cancer Center Amsterdam, Amsterdam, the Netherlands.

Objectives: The aim of the present study was to assess the outcomes of radical and conservative treatment approaches of solid/multicystic and unicystic ameloblastoma in terms of recurrence rates.

Material And Methods: A systematic review and meta-analysis was conducted based on the PRISMA statement. Search was performed using PubMed, Embase, SCOPUS, and Web of Science for articles published from January 1969 until March 2018. Read More

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December 2018

Projected clinical benefit of surveillance imaging for early detection and treatment of breast cancer metastases.

Breast J 2018 Dec 12. Epub 2018 Dec 12.

Department of Radiation Oncology, University of Florida, Gainesville, Florida.

This article presents current best knowledge to assess the projected outcomes benefit of adding multi-modality surveillance imaging to standard follow-up care for breast cancer patients at high risk (>30%) for developing future metastases. This analysis is motivated by recent preliminary clinical studies that have suggested that augmenting systemic treatment of early-stage metastases with targeted surgery and/or radiosurgery achieves significant overall survival and disease-free survival benefit. Our primary aims are to: (a) describe the clinical motivation and scan parameters needed to identify the early onset of metastatic progression in breast cancer patients for effective surgical or radiosurgical treatment; (b) estimate the anticipated survival benefit for high-risk patients under this recommended protocol; and (c) estimate the radiation risks associated with the repeated body imaging of this protocol. Read More

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December 2018

Research Progress on Flavor Compounds and Microorganisms of Maotai Flavor Baijiu.

J Food Sci 2018 Dec 12. Epub 2018 Dec 12.

Sichuan Univ. of Science Engineering, No. 180, Xueyuan Street, Huixing road, Zigong City, Sichuan Province, 643000, China.

Maotai-flavor liquor is one of the three basic traditional Chinese baijiu and is also the most famous baijiu in the world. Guizhou Maotai baijiu is the representative of Maotai-flavor liquor, which has a long history of culture and is prepared using unique brewing methods. However, the main flavor of Maotai-flavor liquor as well as the mechanism by which its aroma is produced is unclear. Read More

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December 2018

Global patterns in excess body weight and the associated cancer burden.

CA Cancer J Clin 2018 Dec 12. Epub 2018 Dec 12.

Scientific Vice President, Surveillance and Health Services Research, American Cancer Society, Atlanta, GA.

The prevalence of excess body weight and the associated cancer burden have been rising over the past several decades globally. Between 1975 and 2016, the prevalence of excess body weight in adults-defined as a body mass index (BMI) ≥ 25 kg/m -increased from nearly 21% in men and 24% in women to approximately 40% in both sexes. Notably, the prevalence of obesity (BMI ≥ 30 kg/m ) quadrupled in men, from 3% to 12%, and more than doubled in women, from 7% to 16%. Read More

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December 2018
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Finding the Sweet Spot: Investigating the Effects of Relationship Closeness and Instrumental Activities in School-based Mentoring.

Am J Community Psychol 2018 Dec 12. Epub 2018 Dec 12.

Department of Human Services, University of Virginia, Charlottesville, VA, USA.

School-based mentoring programs are popular prevention programs thought to influence youth development; but rigorous evaluations indicate that these programs often have small effects on youth outcomes. Researchers suggest that these findings may be explained by (a) mentors and mentees failing to develop a close relationship and (b) mentors not setting goals or focusing on specific skills necessary improve outcomes. We assessed these explanations using data from approximately 1360 mentor and mentee pairs collected through a national study of school-based mentoring (called, "The Student Mentoring Program"). Read More

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December 2018

Doulas in the Operating Room: An Innovative Approach to Supporting Skin-to-Skin Care During Cesarean Birth.

J Midwifery Womens Health 2018 Dec 12. Epub 2018 Dec 12.

Introduction: Skin-to-skin care (SSC) immediately after birth is recommended for all women and their newborns. Barriers to SSC after cesarean birth lead to delays in initiation of this practice. The purpose of this quality improvement project was to implement an innovative approach with volunteer doulas to support initiation of SSC after cesarean for all clients. Read More

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December 2018
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Stressors experienced by children with autism spectrum disorder in Taiwan: Perspectives of children and their parents.

Nurs Health Sci 2018 Dec 11. Epub 2018 Dec 11.

Young Psychiatric Clinic, New Taipei, Taiwan.

Autism spectrum disorder has only recently been recognized as a developmental disability in Taiwan. We conducted an exploratory qualitative descriptive study with children (n = 14, mean age = 13.57 years) and their parents to understand stressors experienced by children with autism spectrum disorder in Taiwan. Read More

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December 2018

BJOG Editor-in-Chief number 9: Stanley Clayton 1963-1973.

Authors:
Philip J Steer

BJOG 2019 Jan;126(1):53

Academic Department of Obstetrics and Gynaecology, Chelsea and Westminster Hospital, Imperial College London, UK.

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January 2019

Key performance indicators and administrative data in an early psychosis service.

Early Interv Psychiatry 2018 Dec 11. Epub 2018 Dec 11.

Rehabilitation Academic Clinical Unit, Metro South Addiction and Mental Health Service, Queensland, Australia.

Aim: This study aimed to introduce a set of administrative key performance indicators (KPIs) for Early Psychosis Services.

Methods: The study design was longitudinal with data retrieved from a 4-year period between January 2009 and December 2013 included in the study. Descriptive statistics and t tests were used to evaluate the KPIs. Read More

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December 2018

Identification of 4-lncRNA prognostic signature in head and neck squamous cell carcinoma.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Head Neck Cancer Center, Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, China.

Deregulated long noncoding RNAs (lncRNA) have been critically implicated in tumorigenesis and serve as novel diagnostic and prognostic biomarkers. Here we sought to develop a prognostic lncRNA signature in patients with head and neck squamous cell carcinoma (HNSCC). Original RNA-seq data of 499 HNSCC samples were retrieved from The Cancer Genome Atlas database, which was randomly divided into training and testing set. Read More

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December 2018

1α, 25-Dihydroxyvitamin D3 alters ectonucleotidase expression and activity in human cutaneous melanoma cells.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Department of Biochemistry and Molecular Biology, PPGBtox, CCNE, Federal University of Santa Maria, Santa Maria, RS, Brazil.

Purpose: We hypothesized that vitamin D decreases rates of adenosine formation in human cutaneous melanoma cells through the inhibition of extracellular adenosine 5'-triphosphate breakdown, thereby affecting tumor cell viability. Therefore, the objective of this study was to explore the mechanisms of action of 1α, 25-dihydroxyvitamin D3 (1,25(OH) D3) on the activity and expression of ectonucleotidases in cutaneous melanoma cells.

Methods: A human melanoma cell line, SK-Mel-28, was treated with 1 to 50 nM of the active vitamin D metabolite (1,25(OH) D3) over 24 hours, followed by determination of NTPDase1/CD39 and ecto-5'-nucleotidase/CD73 activity and expression rates of the purinergic system-related NTPDASE1, NT5E and adenosine deaminase and vitamin D receptor. Read More

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December 2018

TIGD1, a gene of unknown function, involves cell-cycle progression and correlates with poor prognosis in human cancer.

J Cell Biochem 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China.

Background: Trigger transposable element-derived 1 (TIGD1), a human species-specific gene, was identified as a cell cycle-related differentially expressed gene during the formation of liver cancer. As far as we know, there are no reports about the function of TIGD1. This study aimed to explore the expression of TIGD1 in human cancers and establish whether elevated TIGD1 can be used as a prognostic cancer biomarker and its potential role in cancer. Read More

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December 2018

Addressing the empty pelvic syndrome following total pelvic exenteration: does mesh reconstruction help?

Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, Australia.

Aim: Perineal wound complications and pelvic abscesses remain a major source of morbidity after total pelvic exenteration. The void created in the pelvis after these multi-visceral resections leads to fluid accumulation and translocation of bowel within the pelvic cavity, which may increase the risk of pelvic abscess, perineal fluid discharge with perineal wound dehiscence and prolonged ileus. This study describes a novel technique using degradable synthetic mesh with overlying omentum to preclude small bowel and fill the empty space after total pelvic exenteration, and aimed to investigate the rate of pelvic abscess and perineal wound-related complications in this group. Read More

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December 2018

Review article: A primer for clinical researchers in the emergency department: Part VII. Considering a research higher degree in emergency medicine: How does it work, where to start, what to consider.

Emerg Med Australas 2018 Dec 11. Epub 2018 Dec 11.

Paediatric Research in Emergency Departments International Collaborative (PREDICT), Melbourne, Victoria, Australia.

In this series we address important topics for clinicians who participate in research or are considering research as part of their career path in emergency medicine. While much emergency research is successfully done by clinicians without a research higher degree (RHD), undertaking a master's degree or doctorate allows a research topic to be pursued in greater depth. It also provides a solid basis for a future research career in terms of research quality, advanced skills, academic progression and track record, as well as eligibility for grants and RHD supervision. Read More

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December 2018

3D Gold-Modified Cerium and Cobalt Oxide Catalyst on a Graphene Aerogel for Highly Efficient Catalytic Formaldehyde Oxidation.

Small 2018 Dec 7:e1804415. Epub 2018 Dec 7.

Collaborative Innovation Center of Suzhou Nano Science and Technology, College of Chemistry, Chemical Engineering and Materials ScienceSoochow University, 199 Ren'ai Road, Suzhou, 215123, P.R. China.

A hard template method is used to prepare porous gold-doped cerium and cobalt oxide (Au-Ce Co ) materials. A series of 3D Au-Ce Co /graphene aerogel (GA) composites is then fabricated by a facile heating method. The obtained catalysts possess a well-defined structure of ordered arrays of nanotubes and good performance in formaldehyde (HCHO) oxidation. Read More

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December 2018

Phylogenetic analysis of Spirocerca lupi and Spirocerca vulpis reveal high genetic diversity and intra-individual variation.

Parasit Vectors 2018 Dec 14;11(1):639. Epub 2018 Dec 14.

Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Spirocerca lupi is a parasitic nematode of canids that can lead to a severe and potentially fatal disease. Recently, a new species, Spirocerca vulpis, was described from red foxes in Europe, suggesting a high genetic diversity of the Spirocerca spp. infecting canids. Read More

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December 2018
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Using automated electronic medical record data extraction to model ALS survival and progression.

BMC Neurol 2018 Dec 14;18(1):205. Epub 2018 Dec 14.

Department of Neurology, University of Kansas Medical Center, Kansas City, USA.

Background: To assess the feasibility of using automated capture of Electronic Medical Record (EMR) data to build predictive models for amyotrophic lateral sclerosis (ALS) outcomes.

Methods: We used an Informatics for Integrating Biology and the Bedside search discovery tool to identify and extract data from 354 ALS patients from the University of Kansas Medical Center EMR. The completeness and integrity of the data extraction were verified by manual chart review. Read More

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December 2018

The value of an embedded qualitative study in a trial of a second antidepressant for people who had not responded to one antidepressant: understanding the perspectives of patients and general practitioners.

BMC Fam Pract 2018 Dec 14;19(1):197. Epub 2018 Dec 14.

Centre for Academic Primary Care, Oakfield House, Oakfield Grove, Clifton, Bristol, BS8 2BN, UK.

Background: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. The number of prescriptions for antidepressants has risen dramatically in recent years yet up to 50% of patients who are treated for depression with antidepressants do not report feeling better as a result of treatment, and do not show the desired improvement on depression measures. We report a qualitative study embedded in a trial of second antidepressant for people who had not responded to one antidepressant, exploring the acceptability of a combination of antidepressants from the perspectives of both patients and practitioners, together with experiences of participating in a clinical trial. Read More

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December 2018

Mediating effect of aerobic fitness on the association between physical activity and academic achievement among adolescents: A cross-sectional study in Okinawa, Japan.

J Sports Sci 2018 Dec 14:1-8. Epub 2018 Dec 14.

c Faculty of Education , University of the Ryukyus , Okinawa , Japan.

The purpose of this study was to examine the potential role of aerobic fitness (AF) as a mediator of the association between physical activity (PA) and academic achievement (AA) among Japanese junior high school students. A cross-sectional data was collected from 608 7th grade students enrolled at five public junior high schools in two suburban municipalities in Okinawa, Japan. Self-reported PA was assessed using the Patient-Centred Assessment and Counselling for Exercise plus Nutrition questionnaire. Read More

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December 2018