Search Our Scientific Publications & Authors

Drug Alcohol Depend 2018 Dec 3;194:482-486. Epub 2018 Dec 3.

Department of Academic Affairs, Baystate Medical Center, 3601 Main St., Springfield, MA 01199, United States. Electronic address:

Background: Criminal justice involved (CJS) populations with opioid use disorder (OUD) have high rates of relapse, future arrests, and death upon release. While medication for OUD (MOUD) reduces opioid relapse, concerns regarding diversion and stigma limit treatment in CJS populations. Extended release naltrexone (XR-NTX), as an opioid antagonist, may be more acceptable to CJS administrators. Read More

Nurse Educ Today 2018 Nov 29;73:65-70. Epub 2018 Nov 29.

Department of Child Health, School of Medicine, University of Missouri, 430 Sinclair School of Nursing, University of Missouri, Columbia, MO 65211, United States of America. Electronic address:

Introduction: Academic institutions are under pressure to maintain a nearly flawless retention rate, while graduating successful students. The use of standardized admission tests to provide data driven decisions regarding applicant selection is common. The varying reliability and validity of current standardized tests inspired a large Canadian academic institution to use a faculty developed admission test for admission to its practical nursing (PN) program. Read More

J Theor Biol 2018 Dec 3. Epub 2018 Dec 3.

Ruppin Academic Center, School of Engineering, Unit of Engineering & Management, Emek Hefer 40250, Israel. Electronic address:

The classical, monomorphic, evolutionary games analyze competition among phenotypes while implicitly assuming monomorphic transmission of phenotypic attributes to successive generations. The recently formulated polymorphic evolutionary game theory (PEGT), which adds the underlying genetics and sexual reproduction to evolutionary games, has the potential to revolutionize game theoretical modeling of co-evolutionary processes. In this paper, I apply PEGT methods to the analysis of animal conflicts ࣧ the oldest, and one of the best-developed areas of evolutionary game modeling. Read More

Cell Signal 2018 Dec 3. Epub 2018 Dec 3.

Division of Cell Matrix Biology & Regenerative Medicine, UK. Electronic address:

Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark of early photodamage and that these ECM assemblies are susceptible in vitro to physiologically attainable doses of ultraviolet radiation (UVR). Here, we test the hypotheses that UVR-mediated photo-oxidation is the primary driver of fibrillin microfibril and fibronectin degradation and that prior UVR exposure will enhance the subsequent proteolytic activity of UVR-upregulated matrix metalloproteinases (MMPs). Read More

Am J Obstet Gynecol 2018 Dec 3. Epub 2018 Dec 3.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY 10021.

Background: Age-related decline in reproductive potential is mainly due to the increased incidence of aneuploidy. Furthermore, two recent studies have shown that euploid embryos of older women may have a lower implantation potential compared to those of younger women, suggesting that aging might compromise embryos beyond their ploidy status. However, the inherent limitations of these studies preclude solid conclusions. Read More

Ann Am Thorac Soc 2018 Dec 6. Epub 2018 Dec 6.

University Medical CenterUtrecht, Utrecht, Netherlands.

Rationale: Myocardial injury, as reflected by elevated cardiac troponin levels in plasma, is common in patients with community-acquired pneumonia (CAP), but its temporal dynamics and etiology remain unknown.

Objectives: Our aim was to determine the incidence of troponin release in patients with CAP and identify risk factors which may point to underlying etiologic mechanisms.

Methods: We included consecutive patients admitted with severe CAP to two intensive care units in the Netherlands between 2011 and 2015. Read More

Cochrane Database Syst Rev 2018 Dec 5;12:CD009461. Epub 2018 Dec 5.

Academic Centre for General Practice, Cochrane Belgium, Kapucijnenvoer 33, blok J bus 7001, Leuven, Belgium, 3000.

Background: Observational studies suggest higher pregnancy rates after the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions, which are present in 10% to 15% of women seeking treatment for subfertility.

Objectives: To assess the effects of the hysteroscopic removal of endometrial polyps, submucous fibroids, uterine septum or intrauterine adhesions suspected on ultrasound, hysterosalpingography, diagnostic hysteroscopy or any combination of these methods in women with otherwise unexplained subfertility or prior to intrauterine insemination (IUI), in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).

Search Methods: We searched the following databases from their inception to 16 April 2018; The Cochrane Gynaecology and Fertility Group Specialised Register, the Cochrane Central Register of Studies Online, ; MEDLINE, Embase , CINAHL , and other electronic sources of trials including trial registers, sources of unpublished literature, and reference lists. Read More

PLoS One 2018 6;13(12):e0208916. Epub 2018 Dec 6.

Federal University of Sergipe, Aracaju, Brazil.

The aim of this study was to identify the levels of physical activity and sedentary behaviour of children and adolescents with sickle cell disease (SCA) compared to healthy individuals. A cross-sectional study with a quantitative approach was performed at a reference center for the treatment of patients with hemoglobinopathies in northeastern Brazil. Patients were recruited between October 2015 and January 2017. Read More

PLoS One 2018 6;13(12):e0208571. Epub 2018 Dec 6.

Haaglanden Medical Center, The Hague, the Netherlands.

Aim: Increasing evidence exists with respect to the relation between stressful life events and functional constipation (FC). We aimed to investigate the prevalence of FC in Palestinian refugee preschool children and to determine if stress and trauma exposure are risk factors of FC in these children.

Methods: From November 2013 until May 2014, a cross-sectional survey was conducted in West Bank, Gaza and Jordan. Read More

PLoS One 2018 6;13(12):e0208435. Epub 2018 Dec 6.

Occupational and environmental medicine, Public Health and Community Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Recurrent headache, abdominal and musculoskeletal pain are common in adolescents and it is therefore important to understand their impact on the transitional period from childhood to adulthood. However, studies of the prevalence over time and implications on educational outcomes are still limited, especially regarding multiple pain symptoms. The present study material consists of questionnaire surveys, completed in 2000 and 2008, including two study populations of 9th grade adolescents aged 15 living in West Sweden (n = 20 877). Read More

PLoS One 2018 6;13(12):e0208406. Epub 2018 Dec 6.

Department of Marine Biology, Texas A&M University at Galveston, Galveston, Texas, United States of America.

Sinking marine oil snow was found to be a major mechanism in the transport of spilled oil from the surface to the deep sea following the Deepwater Horizon (DwH) oil spill. Marine snow formation is primarily facilitated by extracellular polymeric substances (EPS), which are mainly composed of proteins and carbohydrates secreted by microorganisms. While numerous bacteria have been identified to degrade oil, there is a paucity of knowledge on bacteria that produce EPS in response to oil and Corexit exposure in the northern Gulf of Mexico (nGoM). Read More

PLoS One 2018 6;13(12):e0207950. Epub 2018 Dec 6.

Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria.

Introduction: Extracellular vesicles (EV) are shed from a broad variety of cells and play an important role in activation of coagulation, cell to cell interaction and transport of membrane components. They are usually measured as circulating EV in peripheral blood (PB) and other body fluids. However, little is known about the distribution, presence and impact of EV and their subpopulations in bone marrow (BM). Read More

PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.

Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.

Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More

PLoS One 2018 6;13(12):e0202257. Epub 2018 Dec 6.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom.

Objective: To determine whether a tailored multifaceted implementation strategy improves the initial management of patients with suspected encephalitis.

Design: Pragmatic two arm cluster randomised controlled trial.

Setting: Hospitals within the United Kingdom. Read More

Acta Med Port 2018 Nov;31(11):702

Hospital Júlio de Matos. Centro Hospitalar Psiquiátrico de Lisboa. Lisboa; Clínica de Psiquiatria e Psicologia Médica. Faculdade de Medicina. Universidade de Lisboa. Lisboa. Portugal.

Acta Med Port 2018 Nov 30;31(11):614-617. Epub 2018 Nov 30.

Rheumatology Department. Hospital de Santa Maria. Centro Hospitalar Lisboa Norte. Lisbon Academic Medical Centre. Lisbon. Portugal.

Br J Community Nurs 2018 Dec;23(12):618

Academic Lead for Centre for Palliative Care, University of Worcester.

Br J Community Nurs 2018 Dec;23(12):606-609

Principal academic nursing - older people, Bournemouth University.

High quality care is dependent on good clinical judgement and often-complex decision making. Nurses need to be able to justify and defend their clinical decisions. In this article, a third-year nursing student reflects on an incident from a community placement involving a collaborative clinical decision. Read More

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.

Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Unit of Experimental Therapeutics, Institute of Cancer Science, University of Glasgow, Glasgow, UK.

Tumor cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumor microenvironment, and outcome in patients with colorectal cancer. A cohort of 150 patients with stage I-III CRC were utilised to assess tumor cell expression of MCT-1, MCT-2, LDH-1 and LDH5 by immunohistochemistry. Read More

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Langerhans cell histiocytosis (LCH) is a rare myeloid neoplasm characterized by the presence of abnormal CD1a-positive (CD1a )/CD207 histiocytes. Hemophagocytic lymphohistiocytosis (HLH) represents a spectrum of hyperinflammatory syndromes typified by the dysregulated activation of the innate and adaptive immune systems. Patients with LCH, particularly those with multisystem (MS) involvement, can develop severe hyperinflammation mimicking that observed in HLH. Read More

Nicotine Tob Res 2018 Dec 6. Epub 2018 Dec 6.

Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA.

Introduction: National and international organizations have done an excellent job of advocating and promoting breast feeding for all mothers. This study assessed to what extent an intervention increased delivery of cessation assistance to breast-feeding mothers who smoke.

Methods: Data were collected between April and October 2015 in five US states as part of a cluster randomized controlled trial in 10 pediatric practices. Read More

J Clin Endocrinol Metab 2018 Dec 5. Epub 2018 Dec 5.

Molecular Thyroid Research Laboratory, Johannes Gutenberg University (JGU) Medical Center, Mainz, Germany.

Context: The Major Histocompatibility Complex (MHC) strongly contributes to the development of polyglandular autoimmunity (PGA).

Objective: To evaluate the impact of gender on human leukocyte antigen (HLA) association with PGA for the first time.

Design: Cross-sectional immunogenetic study. Read More

Pediatr Crit Care Med 2018 Dec;19(12):1130-1136

All authors: Section of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objectives: High Vasoactive-Inotropic Scores have demonstrated association with poor outcomes in pediatric cardiac ICUs and are being calculated more frequently in studies of critically ill noncardiac patients. Available studies differ in their approach to assigning Vasoactive-Inotropic Scores, making direct comparisons difficult. The goal of this investigation is to compare multiple approaches to Vasoactive-Inotropic Score assignment to determine their strength of association with mortality in a general pediatric intensive care population. Read More

Ther Drug Monit 2018 Dec 4. Epub 2018 Dec 4.

Analytical Services International (ASI), St George's-University of London, Cranmer Terrace, London SW17 0RE, UK.

Background: Measurement of flecainide is useful to optimize dosage and minimize risks of toxicity. Further, there is a need for urgent sample analysis when flecainide is used in transplacental therapy for fetal tachycardia. To this end, we have developed and validated a rapid assay for the measurement of flecainide in human plasma or serum, using a small sample volume (50 µL). Read More

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

J.D. Gonzalo is associate professor of medicine and public health sciences and associate dean for health systems education, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0003-1253-2963. A. Chang is professor of medicine, Gold-Headed Cane Endowed Education Chair in Internal Medicine, University of California, San Francisco, School of Medicine, San Francisco, California. D. R. Wolpaw is professor of medicine and humanities, Penn State College of Medicine, Hershey, Pennsylvania; ORCID: http://orcid.org/0000-0002-7567-2034.

To address gaps in U.S. health care outcomes, medical education is evolving to incorporate new competencies, as well as to align with care delivery transformation and prepare systems-ready providers. Read More

Acad Med 2018 Dec 4. Epub 2018 Dec 4.

A.L. Siefert is engineering director, Yale Center for Biomedical Innovation and Technology (CBIT), and biomedical engineering lecturer, Yale University, New Haven, Connecticut. M.S. Cartiera is investment and innovation director, Yale CBIT and Center for Health Innovation, Yale New Haven Health System, New Haven, Connecticut. A.N. Khalid is clinical director, Yale CBIT, New Haven, Connecticut; and clinical instructor, Harvard Medical School, Boston, Massachusetts. M.C. Nantel is program coordinator, Yale CBIT, New Haven, Connecticut. C.R. Loose is co-executive director, Yale CBIT, New Haven, Connecticut; and chief scientific officer, Frequency Therapeutics, Cambridge, Massachusetts. P.G. Schulam is co-founder, Yale CBIT, chair of Urology, Yale School of Medicine, and faculty director, Tsai Center for Innovative Thinking, Yale University, New Haven, Connecticut. W.M. Saltzman is co-founder, Yale CBIT, and Goizueta Foundation Professor of biomedical and chemical engineering, Yale University, New Haven, Connecticut. M.K. Dempsey is co-executive director, Yale CBIT, New Haven, Connecticut; and entrepreneur-in-residence, Consortia for Improving Medicine with Innovation & Technology (CIMIT), Boston, Massachusetts.

The process of translating academic biomedical advances into clinical care improvements is difficult, risky, expensive, and poorly understood. Notably, many clinicians who identify health care problems do not have the time or expertise to solve the problems, and many academic researchers are unaware of important gaps in clinical care to which their expertise may apply.Recognizing an opportunity to connect people who can identify health care problems with those who can solve them, the Yale Center for Biomedical Innovation and Technology (CBIT) was established in 2014 to educate and enhance the impact of health care innovators. Read More

Pediatr Crit Care Med 2018 Dec 4. Epub 2018 Dec 4.

Department of Critical Care, Children's National Health System, Washington, DC.

Objectives: Describe a single center experience of hemophagocytic lymphohistiocytosis in a PICU over a 10-year period, to identify clinical features that may be associated with worse outcomes, including mortality, hospital and ICU length of stay, and functional and cognitive impairments on discharge.

Design: Retrospective electronic medical record review, 2007-2017.

Setting: PICU located in a large urban academic quaternary care children's hospital. Read More

Curr Opin Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

Dementia Centre for Research Collaboration, School of Psychiatry, UNSW Sydney, Sydney.

Purpose Of Review: Although young onset dementia (YOD) causes high levels of burden and distress, factors that contribute to its onset are not well understood. Identifying relevant modifiable risk and protective factors for YOD can inform efforts to prevent or delay onset of symptoms to later in life.

Recent Findings: Studies of modifiable factors for YOD have increased in frequency in recent years. Read More

Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

Infect Control Hosp Epidemiol 2018 Dec 6:1-9. Epub 2018 Dec 6.

3Department of Hospital Epidemiology and Infection Control,Johns Hopkins Hospital,Baltimore,Maryland.

Objective: To systematically assess enhanced personal protective equipment (PPE) doffing safety risks.

Design: We employed a 3-part approach to this study: (1) hierarchical task analysis (HTA) of the PPE doffing process; (2) human factors-informed failure modes and effects analysis (FMEA); and (3) focus group sessions with a convenience sample of infection prevention (IP) subject matter experts.

Setting: A large academic US hospital with a regional Special Pathogens Treatment Center and enhanced PPE doffing protocol experience. Read More

J Clin Pediatr Dent 2018 Dec 6. Epub 2018 Dec 6.

Purpose: The purpose of this study was to estimate the prevalence of white spot lesions (WSLs) in various practice settings and patient populations, and to gather information about the treatment timing and modalities used by pediatric dentists in the United States.

Study Design: A fourteen question, multiple choice, electronic survey was developed and distributed to 6,092 active American Academy of Pediatric Dentistry (AAPD) members.

Results: A total of 625 active members responded, garnering a 9. Read More

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, The Netherlands.

Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells that can generate oxidants and are known to display aberrant polarization patterns and defective phagocytic responses in these diseases. Whether these characteristics are linked in one way or another and whether they contribute to the onset and severity of exacerbations in asthma and COPD remains poorly understood. Read More

Ir Med J 2018 08 13;111(7):787. Epub 2018 Aug 13.

Academic Department of Medicine, National University of Ireland Galway, University Road, Galway, Ireland.

Aim This study aims to describe the perceptions of young adults’, parents of young adults’ and health care professionals’ (HCPs) of the transition process for young adults with Type 1 Diabetes in the West of Ireland. Methods Thematic analysis of semi-structured interviews conducted with the three stakeholder groups was performed. Results Young adults hardly noticed the transition, with many of them seeing it as a physical move, whereas parents were more anxious and felt their involvement was still needed but not accommodated. Read More

Acta Bioeng Biomech 2018 ;20(4):19-24

Medical University of Łódź, Unit of General Dentistry of Department of Restorative Dentistry, Łódź, Poland.

Purpose: Teeth caries is one of predominant civilization diseases. Dental fillings with antimicrobial addition might allow prevention of secondary caries. The purpose of this study was to evaluate hardness and tensile strength of cetylpyridinium chloride modified water activated glass-ionomer cement. Read More

Pers Soc Psychol Bull 2018 Dec 6:146167218814003. Epub 2018 Dec 6.

3 University of Virginia, Charlottesville, USA.

Social judgment is shaped by multiple biases operating simultaneously, but most bias-reduction interventions target only a single social category. In seven preregistered studies (total N > 7,000), we investigated whether asking participants to avoid one social bias affected that and other social biases. Participants selected honor society applicants based on academic credentials. Read More

Ir Med J 2018 06 7;111(6):775. Epub 2018 Jun 7.

Academic Department of Paediatrics, National University of Ireland, Galway, Ireland

Oral rehydration therapy (ORT) remains the ideal first line therapy for acute gastroenteritis (AGE). Our aim was to assess the impact of introducing an Oral Fluid Challenge (OFC) protocol on outcomes such as intravenous fluid use and documentation in our institution. A single centre study with data collected retrospectively pre-implementation (April 2015) of the OFC protocol and post implementation (April 2016). Read More

Ultrasound Obstet Gynecol 2018 Dec 6. Epub 2018 Dec 6.

Academic Department Development and Regeneration, Cluster Woman and Child, Biomedical Sciences, Faculty of Medicine, Catholic University of Leuven, Leuven, Belgium.

Objective: To assess the neurodevelopmental outcome of children with spina bifida aperta (SBA) who were treated prenatally as compared to those treated postnatally.

Methods: We performed a systematic review of the literature comparing neurological outcomes of prenatally and postnatally repaired spina bifida in Pubmed/MEDLINE, Embase, Web of Science and Cochrane Library. We retrieved all randomized and non-randomized prospective controlled studies. Read More

Clin Exp Optom 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, The James Cook University Hospital, Middlesbrough, UK.

Laryngoscope 2018 Dec 5. Epub 2018 Dec 5.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

Objectives/hypothesis: Currently, due to the rarity of pathology, there are limited data surrounding outcomes of pediatric skull base surgery. Traditionally, surgeons have proceeded with caution when electing endonasal endoscopic transsellar/transplanum approaches to the skull base in pediatric patients due to poor sphenoid pneumatization. In this study, we review outcomes of endoscopic pediatric skull base surgery based on sphenoid pneumatization patterns. Read More

Infection 2018 Dec 5. Epub 2018 Dec 5.

Department of Sciences for Health Promotion "G. D'Alessandro", University of Palermo, Palermo, Italy.

Purpose: We aimed to assess the diagnostic reliability of two indirect biomarkers, APRI and FIB-4, for the staging of liver fibrosis using transient elastography (TE) as reference standard, among HIV/HCV co-infected and HCV mono-infected patients.

Methods: This is an observational, retrospective study on subjects who had access to the RESIST HCV from October 2013 to December 2016, a regional network encompassing 22 hospitals and academic centers throughout Sicily. Sensitivity, specificity and diagnostic accuracy of indirect biomarkers for liver stiffness measurement (LSM) < 9. Read More

Ophthalmol Ther 2018 Dec 5. Epub 2018 Dec 5.

Manchester Royal Eye Hospital, Manchester Academic Health Science Centre, Manchester, UK.

Introduction: Infantile nephropathic cystinosis (INC) is an autosomal recessive lysosomal disorder in which patients develop deposits of cystine crystals in their kidneys and corneas from a young age.

Methods: We conducted a retrospective analysis of children with INC seen by ophthalmologists at the Manchester Royal Eye Hospital between 2002 and 2018, to evaluate clinical findings, symptoms and treatment.

Results: Twenty-two children diagnosed with INC from age 0 (prenatally) to 11 years were assessed. Read More

Arch Womens Ment Health 2018 Dec 6. Epub 2018 Dec 6.

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.

Parenthood represents a major biological, social and environmental life change. Mental health disorders are common in parents and impact both the parent and their offspring. However, the relationship between parenthood and mental health and the direction of these effects are poorly understood. Read More

Eur Child Adolesc Psychiatry 2018 Dec 5. Epub 2018 Dec 5.

City, University of London, London, UK.

Children and adolescents with developmental language disorder (DLD) are, overall, vulnerable to difficulties in emotional adjustment and in peer relations. However, previous research has shown that different subgroups follow different trajectories in respect to the quality of peer relations. Less is known about the trajectories of emotional development. Read More

Prev Sci 2018 Dec 5. Epub 2018 Dec 5.

Global Center for Applied Health Research, Arizona State University, 411 N. Central Avenue, Suite 720, Phoenix, AZ, 85004-0693, USA.

This article describes a test in Guatemala City of Mantente REAL, a linguistically adapted version of the keepin' it REAL universal substance use prevention curriculum for early adolescents that teaches culturally grounded drug resistance, risk assessment, and decision making skills. Academic researchers collaborated with a local non-profit to recruit and randomize 12 elementary schools in Guatemala City to intervention and comparison conditions. Regular classroom teachers were trained to deliver the ten-lesson Mantente REAL (MR) manualized curriculum to sixth-grade students. Read More

Adv Health Sci Educ Theory Pract 2018 Dec 5. Epub 2018 Dec 5.

Professional Performance Research Group, Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

An optimal learning climate is crucial for the quality of residency training and may also improve residents' well-being and empathy. We investigated the associations of learning climate with residents' work-related well-being. A multicenter questionnaire study was performed among 271 surgery and gynaecology residents in 21 training programs from September 2012 to February 2013. Read More

Environ Monit Assess 2018 Dec 5;191(1). Epub 2018 Dec 5.

School of Geography, Geomatics and Planning, Jiangsu Normal University, Xuzhou, 221116, Jiangsu, China.

Habitat selection by the Chinese horseshoe bat (Rhinolophus sinicus) in the Wuling Mountains was studied in this paper. Global positioning system (GPS), remote sensing (RS) and geographic information system (GIS) technologies were used to obtain ground survey data and analyse the habitat factors driving the distribution of R. sinicus. Read More

Heliyon 2018 Nov 23;4(11):e00963. Epub 2018 Nov 23.

Department of Science and Mathematics Education, University of Extremadura, Avda. de Elvas s/n, Badajoz, 06006, Spain.

Density is one of the most misunderstood concepts amongst the most basic scientific ones, although it is studied even from the earlier academic stages. This is the reason teachers must know its implications as well as possible, including not only the classical definition or what students called "formula" (density is equal to mass divided by volume) but also the concept itself (that is, an intensive matter property). According to this concern, the current research focuses its interest in studying how different teaching methodologies have different outputs in the learning process of pre-service primary teachers. Read More

Alzheimers Dement (N Y) 2018 13;4:628-635. Epub 2018 Nov 13.

Krembil Research Institute, University Health Network, Toronto, ON, Canada.

As the leading cause of dementia worldwide, Alzheimer's disease has garnered intense academic and clinical interest. Yet, trials in search of a disease-modifying therapy have failed overwhelmingly. We suggest that, in part, this may be attributable to the influence of disruptive variables inherent to the framework of a clinical trial. Read More

Data Brief 2018 Dec 27;21:1924-1936. Epub 2018 Oct 27.

Institute of Advanced Ceramics, Hamburg University of Technology, Denickestraße 15, 21073 Hamburg, Germany.

This data article describes the detailed parameters for synthesizing mullite inverse opal photonic crystals via Atomic Layer Deposition (ALD), as well as the detailed image analysis routine used to interpret the data obtained by the measurement of such photonic crystals, before and after the heat treatment, via Ptychographic X-ray Computed Tomography (PXCT). The data presented in this article are related to the research article by Furlan and co-authors entitled "Photonic materials for high-temperature applications: Synthesis and characterization by X-ray ptychographic tomography" (Furlan et al., 2018). Read More