205,023 results match your criteria Academic Medicine[Journal]


Postimplant biological aortic prosthesis degeneration: challenges in transcatheter valve implants.

Eur J Cardiothorac Surg 2018 Dec 11. Epub 2018 Dec 11.

Department of Cardio-Thoracic Surgery, Maastricht University Medical Centre, Maastricht, Netherlands.

Surgical aortic valve replacement (SAVR) is highly effective and can be achieved with relatively low risk in patients with severe aortic stenosis. Bioprostheses have been used most frequently during the past 60 years. However, the function of biological valves usually declines after 10-15 years from implant when structural valve degeneration occurs often mandating a reoperation once valve dysfunction becomes haemodynamically significant. Read More

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December 2018
3.304 Impact Factor

Intra-articular Steroids vs Saline for Lumbar Z-Joint Pain: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial.

Pain Med 2018 Dec 12. Epub 2018 Dec 12.

Department of Physical Medicine and Rehabilitation, Vanderbilt University, Nashville, Tennessee.

Objective: To determine if intra-articular (IA) injection of corticosteroids is effective in reducing the need for radiofrequency ablation (RFA) in those with dual comparative medial branch block (MBB)-confirmed lumbar z-joint pain.

Design: This was a randomized, double blind, placebo-controlled study.

Setting: Two academic medical centers. Read More

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December 2018
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Molecular point-of-care testing for influenza to improve early neuraminidase inhibitor treatment and outcomes in hospitalised adults.

Clin Infect Dis 2018 Dec 9. Epub 2018 Dec 9.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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December 2018

How Online Family History Tool Design and Message Content Impact User Perceptions: An Examination of Family HealthLink.

Public Health Genomics 2018 Dec 12:1-14. Epub 2018 Dec 12.

Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.

Background: Family health history tools have the ability to improve health outcomes and promote patient-provider communication, but some research suggests their effectiveness is limited. Tool design features may heavily influence users' perceptions of the tools.

Aims: This study provides a summative evaluation of the Family HealthLink tool, which assesses cancer and coronary heart disease risk based on personal and family health history, to better understand how tool design and message content impact user perceptions. Read More

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December 2018

Point-of-care lung ultrasound for the detection of pulmonary manifestations of malaria and sepsis: An observational study.

PLoS One 2018 12;13(12):e0204832. Epub 2018 Dec 12.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Introduction: Patients with severe malaria or sepsis are at risk of developing life-threatening acute respiratory distress syndrome (ARDS). The objective of this study was to evaluate point-of-care lung ultrasound as a novel tool to determine the prevalence and early signs of ARDS in a resource-limited setting among patients with severe malaria or sepsis.

Materials And Methods: Serial point-of-care lung ultrasound studies were performed on four consecutive days in a planned sub study of an observational cohort of patients with malaria or sepsis in Bangladesh. Read More

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December 2018

Design and rationale of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study.

J Cardiovasc Med (Hagerstown) 2018 Dec 11. Epub 2018 Dec 11.

Institute of Cardiovascular Sciences, University of Birmingham, SWBH and UHB NHS Trusts, Birmingham, UK.

Aim: Edoxaban, a nonvitamin K antagonist oral anticoagulant, is an oral factor Xa inhibitor approved for the prevention of stroke and systemic embolism in adult patients with atrial fibrillation and for the treatment and secondary prevention in adult patients with venous thromboembolism (VTE). This study details the design of the Edoxaban Treatment in routiNe clinical prActice for patients with Atrial Fibrillation in Europe (ETNA-AF-Europe) study - a postauthorization observational study, which is part of the postapproval plan for edoxaban agreed with the European Medicines Agency.

Methods: The ETNA-AF-Europe study (Clinicaltrials. Read More

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December 2018
1 Read

Academic nursing scholarship redefined.

Authors:
Tonja M Hartjes

J Am Assoc Nurse Pract 2018 Dec;30(12):664-666

College of Nursing, University of Florida, Gainesville, Florida.

The American Association of Colleges of Nursing (AACN) last defined academic nursing scholarship in 1999. The AACN recognized faculty scholarship must align with the increasingly complex and dynamic health care environment to prepare nurses for an ever-changing future. The new, broader definition recognizes multiple ways of knowing and values all scholarly contributions, which affect nursing science and the health care system. Read More

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December 2018

Cardiotoxicity with trabectedin in the treatment of advanced soft tissue sarcoma.

Anticancer Drugs 2019 Jan;30(1):110-115

Department of Oncology, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Cambridge, UK.

Trabectedin is used routinely in the palliative management of patients with advanced soft tissue sarcoma. It is not generally considered to be cardiotoxic, and there is no specific caution for its use in patients with a history of cardiac disease or risk factors. Here, we report six cases from a single academic centre where life-threatening cardiotoxicity occurred acutely during treatment with trabectedin. Read More

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January 2019

Standards of Care for Hypoparathyroidism in Adults.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

B Clarke, Medicine, Mayo Clinic School of Medicine, Rochester, MN, USA, Rochester, United States.

Purpose: To provide practice recommendations for the diagnosis and management of hypoparathyroidism in adults Methods: Key questions pertaining to the diagnosis and management of hypoparathyroidism were addressed following a literature review. We searched PubMed, MEDLINE, EMBASE and Cochrane databases from January 2000 to March 2018 using keywords "hypoparathyroidism, diagnosis, treatment, calcium, PTH, calcidiol, calcitriol, hydrochlorothiazide and pregnancy". Only English language papers involving humans were included. Read More

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December 2018

The Search for Efficacious New Therapies in Sepsis Needs to Embrace Heterogeneity.

Am J Respir Crit Care Med 2018 Dec 12. Epub 2018 Dec 12.

University of Edinburgh, Roslin Institute, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

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December 2018

Learning best-practices in journalology: course description and attendee insights into the inaugural EQUATOR Canada Publication School.

BMC Proc 2018 23;12(Suppl 10):18. Epub 2018 Aug 23.

2Child Health Evaluative Sciences, The Hospital for Sick Children Research Institute, Toronto, Canada.

Background And Purpose: Dissemination of research results is a key component of the research continuum and is commonly achieved through publication in peer-reviewed academic journals. However, issues of poor quality reporting in the research literature are well documented. A lack of formal training in journalology (i. Read More

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Nursing students' perception about humanized care: an integrative review.

Rev Bras Enferm 2018 ;71(suppl 6):2800-2807

Universidade Federal Fluminense, School of Nursing. Niterói, Rio de Janeiro, Brazil.

Objective: To analyze the productions of knowledge about the students' perception of humanized care.

Method: Study of bibliographical revision of the integrative type. The databases Pubmed, Lilacs, Cuiden and the SciELO virtual library were chosen for selection in October 2017, using the health descriptors "Students, Nursing", "Perception" and "Humanization of assistance", in the languages Portuguese, English and Spanish. Read More

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January 2018

[Insufficient levels of physical activity of adolescents associated with sociodemographic, environmental and school factors].

Cien Saude Colet 2018 Dec;23(12):4277-4288

Centro de Ciências da Saúde e do Esporte, Universidade do Estado de Santa Catarina. R. Paschoal Simoni 358, Coqueiros. 88080-350 Florianópolis SC Brasil.

This study investigated the associations between the level of physical activity with sociodemographic, environmental and academic factors of adolescents. Two thousand five hundred and forty-five adolescents aged between 14 and 18 from Florianópolis and neighboring cities participated in this study. The short version of the International Physical Activity Questionnaire (IPAQ) was used. Read More

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December 2018

Factors associated with and impact of burnout in nursing and residential home care workers for the elderly.

Acta Biomed 2018 Dec 7;89(7-S):60-69. Epub 2018 Dec 7.

Department of Psychology, Swansea University.

Background And Aim Of The Work: Numbers of elderly people worldwide continue to grow. Increasingly these individuals require nursing and residential care to meet their needs. Nursing is an occupation associated with burnout amongst its workforce, associated with increases of emotional exhaustion, depersonalisation and decreases in personal accomplishment. Read More

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December 2018

Depression, anxiety, stress, and stressors among rural adolescents studying in Pune and a rural block of Nanded district of Maharashtra, India.

Indian J Public Health 2018 Oct-Dec;62(4):311-314

Professor and Head, Department of Community Medicine, Bharati Vidyapeeth Medical College, Pune, Maharashtra, India.

Adolescent population is the major demographic and economic force of a nation. Adolescent mental health not only affects overall health at present but also in future life. In this cross-sectional study, 461 rural adolescent students studying in Pune city and the rural area from a block in Nanded district, Maharashtra, were administered a prevalidated, pretested Marathi depression anxiety and stress scale-21 tool including correlated factors to assess the magnitude of depression, anxiety, and stress and its stressors. Read More

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December 2018

Dynamic prediction of transition to psychosis using joint modelling.

Schizophr Res 2018 Dec 7;202:333-340. Epub 2018 Jul 7.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia; Centre for Youth Mental Health, The University of Melbourne, Australia.

Considerable research has been conducted seeking risk factors and constructing prediction models for transition to psychosis in individuals at ultra-high risk (UHR). Nearly all such research has only employed baseline predictors, i.e. Read More

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December 2018

Actual 5-Year Survivors After Surgical Resection of Hilar Cholangiocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgery, Stanford University, Stanford, CA, USA.

Background: The prevalence and characteristics of actual 5-year survivors after surgical treatment of hilar cholangiocarcinoma (HC) have not been described previously.

Methods: Patients who underwent resection for HC from 2000 to 2015 were analyzed through a multi-institutional registry from 10 U.S. Read More

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December 2018
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Red Flags for early referral of people with symptoms suggestive of narcolepsy: a report from a national multidisciplinary panel.

Neurol Sci 2018 Dec 12. Epub 2018 Dec 12.

IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Objective: Narcolepsy is a lifelong disease, manifesting with excessive daytime sleepiness and cataplexy, arising between childhood and young adulthood. The diagnosis is typically made after a long delay that burdens the disease severity. The aim of the project, promoted by the "Associazione Italiana Narcolettici e Ipersonni" is to develop Red Flags to detect symptoms for early referral, targeting non-sleep medicine specialists, general practitioners, and pediatricians. Read More

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December 2018

"All the ward's a stage": a qualitative study of the experience of direct observation of handoffs.

Adv Health Sci Educ Theory Pract 2018 Dec 11. Epub 2018 Dec 11.

The Hospital for Sick Children, Toronto, ON, Canada.

Direct observation of clinical skills is central to assessment in a competency-based medical education model, yet little is known about how direct observation is experienced by trainees and observers. The objective of the study is to explore how direct observation was experienced by residents and faculty in the context of the I-PASS Handoff Study. In this multi-center qualitative study, we conducted focus groups and semi-structured interviews of residents and faculty members at eight tertiary pediatric centers in North America that implemented the I-PASS Handoff Bundle. Read More

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December 2018

Gynecologic radiation oncology patients report unmet needs regarding sexual health communication with providers.

J Cancer Res Clin Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Radiation Oncology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: Following radiation therapy (RT), women with gynecologic malignancies report high rates of sexual dysfunction, but little is known regarding sexual health communication between these patients and health-care providers. This study assessed these patients' beliefs/attitudes toward providers' sexual history taking.

Methods: Surveys were administered to women who presented for follow-up care for gynecologic cancers in an academic radiation oncology department. Read More

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December 2018

Analysis of enhanced nitrogen removal mechanisms in a validation wastewater treatment plant containing anammox bacteria.

Appl Microbiol Biotechnol 2018 Dec 11. Epub 2018 Dec 11.

Department of Civil and Environmental Engineering, National University of Singapore, Block E2-02-13, 1 Engineering Drive 3, Singapore, 117576, Singapore.

Anammox bacteria have attracted attention due to their apparent importance in saving energy and reducing organic chemical demands. Here, we report the detection and quantification of anammox bacteria with an improved primer set in a validation wastewater treatment plant. The improved primer set was shown to detect a broad range of anammox bacteria (47. Read More

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December 2018

Risk of Clinically Relevant Pericardial Effusion After Pediatric Cardiac Surgery.

Pediatr Cardiol 2018 Dec 11. Epub 2018 Dec 11.

Division of Pediatric Cardiology, Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300RC, Leiden, The Netherlands.

Pericardial effusion (PE) after pediatric cardiac surgery is common. Because of the lack of a uniform classification of the presence and severity of PE, we evaluated PE altering clinical management: clinically relevant PE. Risk factors for clinically relevant PE were studied. Read More

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December 2018
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Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine.

Eur Arch Psychiatry Clin Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/University of Heidelberg, Mannheim, Germany.

Obsessive-compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. Read More

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December 2018
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Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

http://ow.ly/sTrf30my3jw. Read More

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October 2018

Onlay Technique in Incisional Hernia Repair-A Systematic Review.

Front Surg 2018 27;5:71. Epub 2018 Nov 27.

Department of Surgery and Center for Minimally Invasive Surgery, Academic Teaching Hospital of Charité Medical School, Vivantes Hospital, Berlin, Germany.

A meta-analysis that compared the onlay vs. sublay technique in open incisional hernia repair identified better outcomes for the sublay operation. Nonetheless, an Expert Consensus Guided by Systematic Review found the onlay mesh location useful in certain settings. Read More

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November 2018

Retrospective Analysis of Patients With Prostate Cancer Initiating GnRH Agonists/Antagonists Therapy Using a German Claims Database: Epidemiological and Patient Outcomes.

Front Oncol 2018 27;8:543. Epub 2018 Nov 27.

Department of Urology, University Hospital Schleswig-Holstein, Luebeck, Germany.

The objective of this study was to obtain real-world information on gonadotropin-releasing hormone agonist/antagonist (GnRHa) therapy in patients with advanced prostate cancer (PCa). Anonymized, routine healthcare claims data from approx. 75 German statutory health insurance funds from 2010-2015 ( = 4,205,227) were analyzed. Read More

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November 2018

Sex hormones alter the response of Toll-like receptor 3 to its specific ligand in fallopian tube epithelial cells.

Clin Exp Reprod Med 2018 Dec 30;45(4):154-162. Epub 2018 Nov 30.

Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Objective: The fallopian tubes play a critical role in the early events of fertilization. The rapid innate immune defense is an important part of the fallopian tubes. Toll-like receptor 3 (TLR3), as a part of the innate immune system, plays an important role in detecting viral infections. Read More

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December 2018

Progression of subclinical and clinical cardiovascular disease in a UK SLE cohort: the role of classic and SLE-related factors.

Lupus Sci Med 2018 17;5(1):e000267. Epub 2018 Nov 17.

Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Faculty of Biology Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

Objectives: We aimed to describe the rate and determinants of carotid plaque progression and the onset of clinical cardiovascular disease (CVD) in a UK SLE cohort.

Methods: Female patients with SLE of white British ancestry were recruited from clinics in the North-West of England and had a baseline clinical and CVD risk assessment including measurement of carotid intima-media thickness (CIMT) and plaque using B-mode Doppler ultrasound. Patients were followed up (>3. Read More

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November 2018

Review of the effects of self-stigma and perceived social stigma on the treatment-seeking decisions of individuals with drug- and alcohol-use disorders.

Subst Abuse Rehabil 2018 23;9:115-136. Epub 2018 Nov 23.

Department of Psychiatry, Louisiana State University Health Sciences Center, Baton Rouge, LA, USA,

Substance-use disorders are a public health crisis globally and carry with them significant morbidity and mortality. Stigma toward people who abuse these substances, as well as the internalization of that stigma by substance users, is widespread. In this review, we synthesized the available evidence for the role of perceived social stigma and self-stigma in people's willingness to seek treatment. Read More

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November 2018

A novel scale for describing corneal staining.

Clin Ophthalmol 2018 19;12:2369-2375. Epub 2018 Nov 19.

Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, ON N2L 3G1, Canada,

The assessment of corneal staining is a commonly conducted procedure in both clinical practice and as part of various research studies. Different grading scales are employed by many clinicians and researchers to undertake this procedure for corneal staining comparisons between eyes, products and over time. This paper describes the development and use of a grading scale for corneal staining undertaken at an academic research site. Read More

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November 2018

Spectrum of parasitic infections in centrifuged urine sediments from a newly developed tertiary care centre in Central India.

J Parasit Dis 2018 Dec 29;42(4):608-615. Epub 2018 Oct 29.

3Department of Microbiology, All India Institute of Medical Sciences, Saket Nagar, Bhopal, MP 462024 India.

Detection of urinary parasites is relatively rare and incidental finding in routine urine examination. Common urinary parasitic infections as described in literature include Trichomonas, and Microfilaria. is known to cause vaginitis and urethritis, and may be found in urine sediments. Read More

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December 2018

ALK positively regulates MYCN activity through repression of HBP1 expression.

Oncogene 2018 Dec 11. Epub 2018 Dec 11.

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

ALK mutations occur in 10% of primary neuroblastomas and represent a major target for precision treatment. In combination with MYCN amplification, ALK mutations infer an ultra-high-risk phenotype resulting in very poor patient prognosis. To open up opportunities for future precision drugging, a deeper understanding of the molecular consequences of constitutive ALK signaling and its relationship to MYCN activity in this aggressive pediatric tumor entity will be essential. Read More

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December 2018

The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing α-synuclein.

Sci Signal 2018 Dec 11;11(560). Epub 2018 Dec 11.

Department of Neurological Surgery, University of Wisconsin-Madison, Madison, WI 53792, USA.

Ischemic stroke, which is caused by a clot that blocks blood flow to the brain, can be severely disabling and sometimes fatal. We previously showed that transient focal ischemia in a rat model induces extensive temporal changes in the expression of cerebral microRNAs, with a sustained decrease in the abundance of miR-7a-5p (miR-7). Here, we evaluated the therapeutic efficacy of a miR-7 mimic oligonucleotide after cerebral ischemia in rodents according to the Stroke Treatment Academic Industry Roundtable (STAIR) criteria. Read More

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December 2018

Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.

Thorax 2018 Dec 11. Epub 2018 Dec 11.

Department of Respiratory and Sleep Medicine, Royal North Shore Hospital, St Leonards, New South Wales, Australia.

Rationale: Highly prevalent and severe sleep-disordered breathing caused by acute cervical spinal cord injury (quadriplegia) is associated with neurocognitive dysfunction and sleepiness and is likely to impair rehabilitation.

Objective: To determine whether 3 months of autotitrating CPAP would improve neurocognitive function, sleepiness, quality of life, anxiety and depression more than usual care in acute quadriplegia.

Methods And Measurements: Multinational, randomised controlled trial (11 centres) from July 2009 to October 2015. Read More

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December 2018

Association of occupational exposures with cardiovascular disease among US Hispanics/Latinos.

Heart 2018 Dec 11. Epub 2018 Dec 11.

Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, USA.

Objective: Cardiovascular disease (CVD) is a leading cause of mortality and morbidity in the USA. The role of occupational exposures to chemicals in the development of CVD has rarely been studied even though many agents possess cardiotoxic properties. We therefore evaluated associations of self-reported exposures to organic solvents, metals and pesticides in relation to CVD prevalence among diverse Hispanic/Latino workers. Read More

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December 2018

Variation in the Use of Boost Irradiation in Breast-Conserving Therapy in the Netherlands: The Effect of a National Guideline and Cofounding Factors.

Clin Oncol (R Coll Radiol) 2018 Dec 8. Epub 2018 Dec 8.

Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, the Netherlands; Department of Health Technology and Services Research, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, the Netherlands; Scientific Committee NABON Breast Cancer Audit (NBCA), the Netherlands.

Aims: To determine the variation in radiation therapy boost use in a nationwide study following adjustment of a national guideline in 2011, as well as to address the relationship to patient, tumour and radiation therapy institutional factors.

Materials And Methods: All invasive breast cancers and non-invasive breast cancers (ductal carcinoma in situ; DCIS) that received external whole-breast radiation between 2011 and 2016 were selected from the Netherlands Cancer Registry. Box plots were used to evaluate variation over time and logistic regression was carried out to address other factors influencing the variation. Read More

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December 2018

Anti-anginal drugs: Systematic review and clinical implications.

Int J Cardiol 2018 Dec 4. Epub 2018 Dec 4.

Centro Cardiologico Universitario, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Via Corriera 1, Cotignola, RA, Italy.

Background: The cornerstone of the treatment of patients affected by stable angina is based on drugs administration classified as first (beta-blockers, calcium channel blockers, short acting nitrates) or second line treatment (long-acting nitrates, ivabradine, nicorandil, ranolazine and trimetazidine). However, few data on comparison between different classes of drugs justify that one class of drugs is superior to another.

Methods: We performed a systematic review of the literature following PRISMA guidelines. Read More

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December 2018

The reproducibility of assessment of white spot lesions adjacent to orthodontic brackets, with a quantitative light induced fluorescence digital camera at different rotations of teeth - an in vitro study.

BMC Oral Health 2018 Dec 11;18(1):209. Epub 2018 Dec 11.

Department of preventive dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Background: A quantitative light-induced fluorescence digital (QLF-D) camera is able to assess demineralizations adjacent to orthodontic brackets. Rotations of teeth during and the presence of the orthodontic appliances may influence the longitudinal follow-up of such lesions over time.

Methods: Brackets were bonded on extracted teeth: 54 incisors and 31 canines. Read More

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December 2018

Embracing complexity and uncertainty to create impact: exploring the processes and transformative potential of co-produced research through development of a social impact model.

Health Res Policy Syst 2018 Dec 11;16(1):118. Epub 2018 Dec 11.

Faculty of Health Sciences, University of Southampton, University Road, Southampton, SO17 1BJ, United Kingdom.

The potential use, influence and impact of health research is seldom fully realised. This stubborn problem has caused burgeoning global interest in research aiming to address the implementation 'gap' and factors inhibiting the uptake of scientific evidence. Scholars and practitioners have questioned the nature of evidence used and required for healthcare, highlighting the complex ways in which knowledge is formed, shared and modified in practice and policy. Read More

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December 2018

Early career GPs, mental health training and clinical complexity: a cross-sectional analysis.

Educ Prim Care 2018 Dec 11:1-8. Epub 2018 Dec 11.

b Discipline of General Practice , University of Newcastle , Callaghan , Australia.

Patients with mental health conditions commonly present in General Practice. Mental health curricula are broad. We do not know that trainees are exposed to the learning they require. Read More

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December 2018

Quantum Dot-labeled Tags Improve Minimal Detection Limit of CA125 in Ovarian Cancer Cells and Tissues.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):326-335. Epub 2018 Aug 12.

Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran AND Immunology Research Center (IRC), Iran University of Medical Sciences, Tehran, Iran.

In recent years, a lot of attention has been paid to quantum dot (QD) nanoparticles as fluorescent sensors for sensitive and accurate detection of cancer biomarkers. Here, using a homemade specific monoclonal antibody against CA125 and QD525- or FITC-labeled probes, expression of this marker in an ovarian cancer cell line and cancer tissues were traced and optical properties of fluorophores were compared qualitatively and quantitatively. Our results clearly showed that besides lower background and exceptionally higher photobleaching resistance, QD525 exhibited higher fluorescent intensity for both ovarian cancer cell and tissues at different exposure times (p<0. Read More

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Evolving network structure of academic institutions.

Appl Netw Sci 2017 19;2(1). Epub 2017 Jan 19.

Department of Mathematics, Trinity College, 300 Summit St., 06106, West Hartford, Connecticut, USA.

Today's colleges and universities consist of highly complex structures that dictate interactions between the administration, faculty, and student body. These structures can play a role in dictating the efficiency of policy enacted by the administration and determine the effect that curriculum changes in one department have on other departments. Despite the fact that the features of these complex structures have a strong impact on the institutions, they remain by-and-large unknown in many cases. Read More

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January 2017

Quantifying the diaspora of knowledge in the last century.

Appl Netw Sci 2016 29;1(1):15. Epub 2016 Nov 29.

Departament d'Enginyeria Informàtica i Matemàtiques, Universitat Rovira i Virgili, Av.da Països Catalans, 26, Tarragona, 43007 Spain.

Academic research is driven by several factors causing different disciplines to act as "sources" or "sinks" of knowledge. However, how the flow of authors' research interests - a proxy of human knowledge - evolved across time is still poorly understood. Here, we build a comprehensive map of such flows across one century, revealing fundamental periods in the raise of interest in areas of human knowledge. Read More

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November 2016

Disconnected, fragmented, or united? a trans-disciplinary review of network science.

Authors:
César A Hidalgo

Appl Netw Sci 2016 20;1(1). Epub 2016 Jul 20.

The MIT Media Lab, Cambridge, MA USA.

During decades the study of networks has been divided between the efforts of social scientists and natural scientists, two groups of scholars who often do not see eye to eye. In this review I present an effort to mutually translate the work conducted by scholars from both of these academic fronts hoping to continue to unify what has become a diverging body of literature. I argue that social and natural scientists fail to see eye to eye because they have diverging academic goals. Read More

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July 2016
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Gene Expression Profiles of Tumor Necrosis Factor-α and Endothelin-1 in Obstructive Sleep Apnea.

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):16-23. Epub 2018 Dec 11.

Department of Otolaryngology and Head and Neck Surgery, Wakayama University Hospital, Wakayama, Japan.

Background/aims: The aim of this study was to observe the relationship between the gene expression profiles of tumor necrosis factor (TNF)-α and endothelin (EDN)-1 and obstructive sleep apnea (OSA).

Methods: A prospective, cross-sectional study performed at a tertiary-care academic center; 108 patients with snoring and day-time sleeplessness were included in this study carried out in the Otolaryngology Department. All patients were evaluated with 1-night polysomnography (PSG). Read More

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December 2018
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Assessment of Postoperative Outcomes in Spinal Epidural Abscess Following Surgical Decompression.

Spine J 2018 Dec 8. Epub 2018 Dec 8.

Center for Spine Health, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Department of Neurosurgery, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA; Cleveland Clinic Lerner College of Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA. Electronic address:

Background Context: A spinal epidural abscess (SEA) is a serious condition that may be managed with antibiotics alone or with decompressive surgery combined with antibiotics.

Purpose: The objectives of this study were to assess the clinical outcomes of SEA after surgical management and to identify the patient-level factors that are associated with outcomes following surgical decompression and removal of SEA.

Study Design/setting: Retrospective chart review analysis. Read More

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December 2018
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Measuring the Impact of Academic Cancer Network Development on Clinical Integration, Quality of Care, and Patient Satisfaction.

J Oncol Pract 2018 Dec;14(12):e823-e833

Yale New Haven Hospital; Yale School of Medicine; Yale Cancer Center; Smilow Cancer Hospital; and Community Health Educators Group, New Haven, CT.

Purpose:: Many US academic centers have acquired community practices to expand their clinical care and research footprint. The objective of this assessment was to determine whether the acquisition and integration of community oncology practices by Yale/Smilow Cancer Hospital improved outcomes in quality of care, disease team integration, clinical trial accrual, and patient satisfaction at network practice sites.

Methods:: We evaluated quality of care by testing the hypothesis that core Quality Oncology Practice Initiative measures at network sites that were acquired in 2012 were significantly different after their 2016 integration into the network. Read More

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December 2018
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Quality Improvement Training in a Variety of Cancer Care Delivery Settings: Experiences From a Comprehensive Cancer Center, an Academic Medical Center, and Community Practices.

J Oncol Pract 2018 Dec;14(12):e815-e822

Beth Israel Deaconess Medical Center; Dana-Farber Cancer Institute; Partners HealthCare; and Massachusetts General Hospital, Boston, MA.

Purpose:: Training clinical and supportive staff in quality improvement (QI) theory and use of QI tools has the potential to improve oncology care delivery. We report our combined experience of providing training to oncologists in a variety of local settings and assess the effect of the training on individual participants and for institutions.

Methods:: Multidisciplinary oncology teams at a comprehensive cancer center, an academic medical center, and community practices were led through experiential QI training that spanned several months. Read More

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December 2018