205,143 results match your criteria Academic Emergency Medicine[Journal]


Methods to Quantify Nanomaterial Association with, and Distribution Across, the Blood-Brain Barrier In Vivo.

Authors:
Robert A Yokel

Methods Mol Biol 2019 ;1894:281-299

Pharmaceutical Sciences Department, University of Kentucky Academic Medical Center, Lexington, KY, USA.

The role and functional anatomy of the blood-brain barrier (BBB) is summarized to enable the investigator to appropriately address evaluation of nanomaterial interaction with, and distribution across, it into brain tissue (parenchyma). Transport mechanisms across the BBB are presented, in relation to nanomaterial physicochemical properties. Measures and test substances to assess BBB integrity/disruption/permeation are introduced, along with how they are used to interpret the results obtained with the presented methods. Read More

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January 2019

Prevalence and cardiac phenotype of patients with a phospholamban mutation.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands.

Pathogenic mutations in the phospholamban (PLN) gene may give rise to inherited cardiomyopathies due to its role in calcium homeostasis. Several PLN mutations have been identified, with the R14del mutation being the most prevalent cardiomyopathy-related mutation in the Netherlands. It is present in patients diagnosed with arrhythmogenic cardiomyopathy as well as dilated cardiomyopathy. Read More

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December 2018
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Differences at surgery between patients with bicuspid and tricuspid aortic valves.

Neth Heart J 2018 Dec 13. Epub 2018 Dec 13.

Department of Cardiology, Amsterdam University Medical Centre, location AMC, Amsterdam, The Netherlands.

Aim: To determine differences in surgical procedures and clinical characteristics at the time of surgery between native bicuspid aortic valves (BAV) and tricuspid aortic valves (TAV) in patients being followed up after aortic valve surgery (AVS).

Methods: In this retrospective cohort study in a non-academic hospital, we identified patients who had a surgeon's report of the number of native valve cusps and were still being followed up. We selected patients with BAV and TAV, and used multivariable regression analyses to identify associations between BAV-TAV and pre-specified clinical characteristics. Read More

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December 2018

Investigating the Association Between Baseline Characteristics (HbA1c and Body Mass Index) and Clinical Outcomes of Fast-Acting Insulin Aspart in People with Diabetes: A Post Hoc Analysis.

Diabetes Ther 2018 Dec 13. Epub 2018 Dec 13.

Clinical and Experimental Endocrinology, University Hospital Leuven, Catholic University of Leuven, Leuven, Belgium.

Introduction: The aim of this study was to investigate the association between baseline characteristics [HbA1c and body mass index (BMI)] and the effect of mealtime fast-acting insulin aspart (faster aspart) relative to insulin aspart (IAsp) or basal-only insulin therapy on several efficacy and safety outcomes in people with diabetes.

Methods: Post hoc analysis of three randomised phase 3a trials in people with type 1 diabetes (T1D; onset 1) and type 2 diabetes (T2D; onset 2 and 3). Participants (N = 1686) were stratified according to baseline BMI (< 25 kg/m, 25-< 30 kg/m, ≥ 30 kg/m) or HbA1c (≤ 58 mmol/mol, > 58-< 64 mmol/mol, ≥ 64 mmol/mol; ≤ 7. Read More

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December 2018
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Modifiable Risk-factors for Keratinocyte Cancers in Australia: A Case-control Study.

Acta Derm Venereol 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Epidemiology and Applied Biostatistics, University Hospital Tübingen, DE-72076 Tübingen, Germany.

Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Read More

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December 2018

Perceived Benefits and Risks of Social Media: Ethiopian Secondary School Students' Perspectives.

J Technol Behav Sci 2018 19;3(4):294-300. Epub 2018 Jun 19.

Department of Psychology, Bahir Dar University, Bahir Dar, Ethiopia.

Recent findings show teenagers use social media increasingly in their daily life. There is also a consensus that social media have both pros and perils on students' academic affairs. The objective of this study is to assess how Ethiopian secondary school students perceive the benefits and risks associated with social media use. Read More

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Proton vs. Photon Radiation Therapy for Primary Gliomas: An Analysis of the National Cancer Data Base.

Front Oncol 2018 28;8:440. Epub 2018 Nov 28.

Department of Therapeutic Radiology, Yale University, New Haven, CT, United States.

To investigate the impact of proton radiotherapy (PBT) on overall survival (OS) and evaluate PBT usage trends for patients with gliomas in the National Cancer Data Base (NCDB). Patients with a diagnosis of World Health Organization (WHO) Grade I-IV glioma treated with definitive radiation therapy (RT) between the years of 2004-13 were identified. Patients were stratified based on WHO Grade and photon radiotherapy (XRT) vs. Read More

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November 2018

Evaluating a Change in Surgical Antibiotic Prophylaxis in Kidney Transplant Recipients.

Cureus 2018 Oct 9;10(10):e3433. Epub 2018 Oct 9.

Surgery, University of Utah, Salt Lake City, USA.

The purpose of this study was to retrospectively evaluate if a change in practice from January 2013 to August 2015 affected the rate of surgical-site infections following kidney transplantation at the single academic medical center. More patients were found to have a surgical-site infection when surgical antibiotics were only given intra-operatively despite a lower incidence of risk factors identified in the literature when compared to the cohort who received antibiotics intra-op and post-op for 24 hours. Read More

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October 2018

Clinical characterization of colitis arising from anti-PD-1 based therapy.

Oncoimmunology 2019 31;8(1):e1524695. Epub 2018 Oct 31.

Department of Medicine, Vanderbilt University, Nashville, TN, USA.

Colitis is a frequent, clinically-significant immune-related adverse event caused by anti-programmed death-1 (PD-1). The clinical features, timing, and management of colitis with anti-PD-1-based regimens are not well-characterized. Patients with advanced melanoma that received either anti-PD-1 monotherapy ("monotherapy") or combined with ipilimumab ("combination therapy") were screened from 8 academic medical centers, to identify those with clinically-relevant colitis (colitis requiring systemic steroids). Read More

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October 2018

Regional working in the East of England: using the UK National Standards for Public Involvement.

Res Involv Engagem 2018 6;4:48. Epub 2018 Dec 6.

1Centre for Research in Public Health and Community Care (CRIPACC), University of Hertfordshire, Hatfield, AL10 9AB UK.

Plain English Summary: Involving patients and members of the public to help shape and carry out research is recommended in health research in the United Kingdom (UK). There are a number of regional networks of Patient and Public Involvement (PPI) groups, which support the collaboration between researchers, patients and public members. We are a group of researchers, patients and public members who came together via a PPI regional network in the East of England to collaborate on a research study about the extent of feedback from researchers to PPI contributors. Read More

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December 2018

Diabetic and Elder Patients Experience Superior Cardiovascular Benefits After Gastric Bypass Induced Weight Loss.

Front Endocrinol (Lausanne) 2018 28;9:718. Epub 2018 Nov 28.

Endocrine, Cardiovascular and Metabolic Research, Unit for Multidisciplinary Research in Biomedicine, University of Porto, Porto, Portugal.

Obesity and obesity related co-morbidities are well-recognized risks for cardiovascular (CV) disease and mortality. Weight loss improves CV risk factors and the efficacy of bariatric surgery in decreasing CV mortality is now well-established. Our aim was to assess CV risk progression and occurrence of CV events in a cohort of patients that underwent Roux-en-Y gastric bypass (RYGB) for obesity treatment in a single academic public center. Read More

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November 2018

Study of stress-induced temporomandibular disorders among dental students: An institutional study.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):147-154

Department of Oral Medicine and Radiology, D J College of Dental Sciences and Research, Ghaziabad, Uttar Pradesh, India.

Aim And Objectives: The aim and objectives of this study are to investigate the various types of stress-inducing factors, most prevalent etiological factor and to determine the correlation between stress and temporomandibular disorders (TMDs) in Dental students in Modinagar, Ghaziabad, Uttar Pradesh.

Materials And Methods: A sample of 450 students were selected for the study divided into two groups of undergraduate (UG) and postgraduate (PG) students further subdivided into UG (1, 2, 3, and 4, interns) and PG (1, 2, 3 year). Study includes clinical evaluation of temporomandibular joint (TMJ) system (TMJ sounds, muscles of mastications, mouth opening, and range of mandibular motion) and questionnaire which covers demographic data (i. Read More

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December 2018

Are non-monetary rewards effective in attracting peer reviewers? A natural experiment.

Scientometrics 2018 20;117(3):1587-1609. Epub 2018 Sep 20.

1Faculty of Economics and Business Administration, Babeş-Bolyai University, 400591 Cluj Napoca, Romania.

Editors of scientific journals meet increasing challenges to find peer reviewers. Rewarding reviewers has been proposed as a solution to incentives peer review, and journals have already started to offer different kinds of rewards, particularly non-monetary ones. However, research so far has mainly explored the efficacy of monetary rewards, while research on non-monetary rewards is barely absent. Read More

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September 2018

Towards understanding the relation between citations and research quality in software engineering studies.

Scientometrics 2018 22;117(3):1453-1478. Epub 2018 Sep 22.

BTH - Blekinge Tekniska Högskola, Karlskrona, Sweden.

The importance of achieving high quality in research practice has been highlighted in different disciplines. At the same time, citations are utilized to measure the impact of academic researchers and institutions. One open question is whether the quality in the reporting of research is related to scientific impact, which would be desired. Read More

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September 2018

Impact of Patient- and Clinician-Reported Cumulative Toxicity on Quality of Life in Patients With Metastatic Castration-Naïve Prostate Cancer.

J Natl Compr Canc Netw 2018 Dec;16(12):1481-1488

Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; Department of Psychiatry, Cancer Center Amsterdam, and Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands; Inserm, UMR 912 'Economic and Social Sciences, Health Systems and Societies (SESSTIM)', Aix-Marseille Université, IRD, Marseille, France; Department of Medical Psychology, Academic Medical Center Amsterdam, Cancer Center Amsterdam, the Netherlands; Department of Epidemiology and Biostatistics Amsterdam Public Health Research Institute, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, the Netherlands; Medical Oncology, Centre François Baclesse - CHU Côte de Nacre, Caen, France; Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif, France; UNICANCER, Paris, France; Department of Biostatistic, Institut Paoli-Calmettes, Marseille, France; Aix Marseille Université, INSERM, IRD, SESSTIM, Marseille, France; Centre Hospitalier Universitaire Rangueil, Toulouse, France; Hôpital Européen Georges Pompidou, Paris, France; and Institut Paoli-Calmettes, Aix-Marseille University, Centre de Recherche en Cancerologie de Marseille (CRCM), Marseille, France.

Current toxicity evaluation is primarily focused on high-grade adverse events (AEs) reported by clinicians. However, the cumulative effect of multiple lower-grade AEs may also impact patients' quality of life (QoL). Further, patient-reported toxicity may be more representative of patients' treatment experiences. Read More

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December 2018

Pulmonary hypertension in chronic lung disease and hypoxia.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

University of Giessen and Marburg Lung Center (UGMLC), Justus-Liebig University Giessen and Member of the German Center for Lung Research (DZL), Giessen, Germany.

Pulmonary hypertension (PH) frequently complicates the course of patients with various forms of chronic lung disease (CLD). CLD-associated PH (CLD-PH) is invariably associated with reduced functional ability, impaired quality of life, greater oxygen requirements and an increased risk of mortality. The aetiology of CLD-PH is complex and multifactorial, with differences in the pathogenic sequelae between the diverse forms of CLD. Read More

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December 2018

Diagnosis of pulmonary hypertension.

Eur Respir J 2018 Dec 13. Epub 2018 Dec 13.

Dept of Pulmonary Circulation and Cardidology, Medical Center for Postgraduate Education, ECZ-Otwock, Otwock, Poland.

A revised diagnostic algorithm provides guidelines for the diagnosis of patients with suspected pulmonary hypertension, both prior to and following referral to expert centres, and includes recommendations for expedited referral of high-risk or complicated patients and patients with confounding comorbidities. New recommendations for screening high-risk groups are given, and current diagnostic tools and emerging diagnostic technologies are reviewed. Read More

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December 2018

Write a Scientific Paper (WASP) - What can I publish [1]? Types of studies.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

Academic Department of Paediatrics, Mater Dei Hospital, Malta. Electronic address:

As an experienced writer, one is often asked the question "what can I publish" by younger and inexperienced colleagues who must publish. This paper will briefly review the reasons why academics publish and will then outline what kind of papers one may be able to publish with relative ease, using personal experience and citing first hand material as a practical guide. Potential authors must cultivate "a lean and hungry look" as competition from fellow writers is stiff, and editors are choosy. Read More

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December 2018
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Write a Scientific Paper (WASP): Academic hoax and fraud.

Authors:
Victor Grech

Early Hum Dev 2018 Dec 10. Epub 2018 Dec 10.

University of Malta, Msida, Malta; Mater Dei Hospital, Msida, Malta. Electronic address:

Academics may deliberately hoax colleagues with false research, so as to forcibly and dramatically make a particular point. Moreover, false research may a process of deliberate and outright fraud. This paper will review a few examples as cautionary tales for academics and researchers. Read More

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December 2018

Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss.

Surg Obes Relat Dis 2018 Dec 29;14(12):1876-1889. Epub 2018 Sep 29.

Stony Brook Medicine, Stony Brook, New York.

Background: Obesity is a significant health problem and additional therapies are needed to improve obesity treatment.

Objective: Determine the efficacy and safety of a 6-month swallowable gas-filled intragastric balloon system for weight loss.

Setting: Fifteen academic and private practice centers in the United States. Read More

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December 2018

Development and Modification of an Outcome Measure to Follow Symptoms of Children with Sinusitis.

J Pediatr 2018 Dec 10. Epub 2018 Dec 10.

Division of General Academic Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objective: To develop a parent-reported Pediatric Rhinosinusitis Symptom Scale (PRSS) that could be used to monitor symptoms of young children with acute sinusitis in response to therapy.

Study Design: We developed an 8-item symptom severity scale and evaluated its internal reliability, construct validity, and responsiveness in children 2-12 years of age with acute sinusitis. Parents of 258 children with acute sinusitis completed the PRSS at the time of diagnosis, as a diary at home, and at the follow-up visit at days 10-12. Read More

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December 2018
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GLP-1RAs in type 2 diabetes: mechanisms that underlie cardiovascular effects and overview of cardiovascular outcome data.

Cardiovasc Diabetol 2018 Dec 13;17(1):157. Epub 2018 Dec 13.

Cardiology Division, Pontifical Catholic University of Campinas Medicine School, Rua Engenheiro Carlos Stevenson 560, Campinas, Sao Paulo, 13092-132, Brazil.

Patients with type 2 diabetes (T2DM) have a substantial risk of developing cardiovascular disease. The strong connection between the severity of hyperglycaemia, metabolic changes secondary to T2DM and vascular damage increases the risk of macrovascular complications. There is a challenging demand for the development of drugs that control hyperglycaemia and influence other metabolic risk factors to improve cardiovascular outcomes such as cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina and heart failure (major adverse cardiovascular events). Read More

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December 2018
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Performance of PRECISE-DAPT Score for Predicting Bleeding Complication During Dual Antiplatelet Therapy.

Circ Cardiovasc Interv 2018 Dec;11(12):e006837

Department of Clinical Epidemiology and Biostatistics, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea (S.-C.Y.).

Background: Dual antiplatelet therapy (DAPT) helps prevent ischemic events after coronary stenting but comes with an increased risk of bleeding. Several risk scores have been proposed for the management of patients receiving DAPT, but no standardized tool exists for the purpose. We sought to compare the performance of the new PRECISE-DAPT (Predicting Bleeding Complication in Patients Undergoing Stent Implantation and Subsequent Dual Antiplatelet Therapy), CRUSADE (Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes with Early Implementation of the American College of Cardiology/American Heart Association Guidelines), and ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) scores for the prediction of bleeding in Korean patients receiving DAPT. Read More

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December 2018

The 9th Santorini Conference: Systems Medicine, Personalised Health and Therapy. "The Odyssey from Hope to Practice", Santorini, Greece, 30 September⁻3 October 2018.

J Pers Med 2018 Dec 12;8(4). Epub 2018 Dec 12.

PRAHealthSciences, Salt Lake City, UT 84124, USA.

The 9th traditional biannual conference on Systems Medicine, Personalised Health & Therapy-"The Odyssey from Hope to Practice", inspired by the Greek mythology, was a call to search for practical solutions in cardio-metabolic diseases and cancer, to resolve and overcome the obstacles in modern medicine by creating more interactions among disciplines, as well as between academic and industrial research, directed towards an effective 'roadmap' for personalised health and therapy. The 9th Santorini Conference, under the Presidency of Sofia Siest, the director of the INSERM U1122; IGE-PCV (www.u1122. Read More

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December 2018

Pediatric Integrative Medicine in Academia: Stanford Children's Experience.

Children (Basel) 2018 Dec 12;5(12). Epub 2018 Dec 12.

Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.

Pediatric integrative medicine is an emerging field which, to date, has not been described in detail in academic medical centers in the United States. Early research of pediatric integrative medicine modalities shows promise for the treatment of common pediatric conditions such as irritable bowel syndrome, acute and chronic pain, headache, and allergy, among others. In light of the growing prevalence of pediatric illnesses and patient complexity, it is crucial to emphasize the patient's overall well-being. Read More

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December 2018

Parental Satisfaction with Caregiving for Children with Developmental Disabilities: Development of a New Assessment Tool.

Children (Basel) 2018 Dec 11;5(12). Epub 2018 Dec 11.

Institute of Nursing and Health Research, Ulster University, Newtownabbey BT37 0QB, Northern Ireland, UK.

Parents of children with developmental disabilities face many challenges. Those who are less satisfied with the care-giving that their children receive may require extra support. This paper reports the development of a Parental Satisfaction with Caring for a child with Developmental Disability Index (PSCDDI), with items derived from literature reviews and pilot testing in Iran. Read More

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December 2018

A Critical Exploration of Child-Parent Attachment as a Contextual Construct.

Behav Sci (Basel) 2018 Dec 11;8(12). Epub 2018 Dec 11.

Department of Education, University of Bath, Bath BA2 7AY, UK.

Bowlby's attachment theory has been employed as a broad and integrative framework to explore human wellness across a range of disciplines. Attachment theory has even been labelled one of the last surviving "grand theories" not to have been completely dismissed, replaced, or extensively reworked. However, despite the ubiquitous nature of some of the theory's fundamental tenets, there are always possibilities for new conceptual development, extension, and revision. Read More

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December 2018

The Effects of Mind-Body Exercise on Cognitive Performance in Elderly: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2018 Dec 9;15(12). Epub 2018 Dec 9.

Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National University, Seoul 08826, Korea.

: As the situation of cognitive aging is getting worse, preventing or treating cognitive decline through effective strategies is highly important. This systematic review aims to investigate whether mind-body exercise is an effective approach for treating cognition decline. : Searches for the potential studies were performed on the eight electronic databases (MEDLINE, Scopus, Web of Science, SPORTDiscus, CINAHL, PsycArtilces, CNKI, and Wanfang). Read More

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December 2018

Facile Fabrication of Amorphous Photonic Structures with Non-Iridescent and Highly-Stable Structural Color on Textile Substrates.

Materials (Basel) 2018 Dec 8;11(12). Epub 2018 Dec 8.

Engineering Research Center for Eco-Dyeing and Finishing of Textiles, Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Amorphous photonic structures with non-iridescent and highly-stable structural color were fabricated via a simple one-step spray-coating technique. With this strategy, the obtained films on textile substrates presented short-ordered and amorphous photonic structures (APSs) similar to the amorphous nanostructures of avian feathers. The structural color presented the same hue when viewed at different angles and could be well controlled by varying the diameters of the SiO₂ nanospheres. Read More

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December 2018

Interpretation of Euphorbia Kansui Stir-Fried with Vinegar Treating Malignant Ascites by a UPLC-Q-TOF/MS Based Rat Serum and Urine Metabolomics Strategy Coupled with Network Pharmacology.

Molecules 2018 Dec 7;23(12). Epub 2018 Dec 7.

Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility, Shaanxi University of Chinese Medicine, Xi'an 712046, China.

stir-fried with vinegar (V-kansui) has promising biological activities toward treating malignant ascites with reduced toxicity compared to crude kansui. But the mechanism concerning promoting the excretion of ascites has not been systematically studied. The purpose of this paper was to investigate the possible mechanism of V-kansui in treating malignant ascites, including metabolic pathways and molecular mechanism using an integrated serum and urine metabolomics coupled with network pharmacology. Read More

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December 2018
2.416 Impact Factor

Needs and Barriers of Teen Mothers in Rural Eastern Uganda: Stakeholders' Perceptions Regarding Maternal/Child Nutrition and Health.

Int J Environ Res Public Health 2018 Dec 7;15(12). Epub 2018 Dec 7.

University of Waterloo. Ontario, Canada. 200 University Avenue West, Waterloo ON N2L 3G1, Canada.

For adolescent mothers in rural Eastern Uganda, nutrition and health may be compromised by many factors. Identifying individual and environmental needs and barriers at local levels is important to inform community-based interventions. This qualitative study used interviews based on constructs from social cognitive theory. Read More

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December 2018

Analysis of the Transcriptome of the Red Seaweed with Emphasis on Reproductive Potential.

Mar Drugs 2018 Dec 7;16(12). Epub 2018 Dec 7.

Departamento de Biología, Facultad de Ciencias del Mar, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, E-35017 Las Palmas, Spain.

is an intertidal marine seaweed and candidate model organism for both industry and academic research, owing to its ability to produce raw materials such as carrageenan. Here we report on the transcriptome of with the aim of providing new insights into the metabolic pathways and other functional pathways related to the reproduction of species. Next-generation sequencing was carried out with subsequent de novo assembly and annotation using state-of-the-art bioinformatic protocols. Read More

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December 2018

Direct enhancement of readiness for wartime critical specialties by civilian-military partnerships for neurosurgical care: residency training and beyond.

Authors:

Neurosurg Focus 2018 Dec;45(6):E17

Military neurosurgery has played an integral role in the development and innovation of neurosurgery and neurocritical care in treating battlefield injuries. It is of paramount importance to continue to train and prepare the next generation of military neurosurgeons. For the Army, this is currently primarily achieved through the military neurosurgery residency at the National Capital Consortium and through full-time out-service positions at the Veterans Affairs-Department of Defense partnerships with the University of Florida, the University of Texas-San Antonio, and Baylor University. Read More

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December 2018

Optical diagnosis expanded to small polyps: post-hoc analysis of diagnostic performance in a prospective multicenter study.

Endoscopy 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, Location Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.

Background: Optical diagnosis can replace histopathology of diminutive (1 - 5 mm) polyps if surveillance intervals based on optical diagnosis of polyps have ≥ 90 % agreement with intervals based on polyp histology and if the negative predictive value (NPV) for predicting neoplastic histology in the rectosigmoid is ≥ 90 %. This study aims to assess whether small (6 - 9 mm) polyps can be included in optical diagnosis strategies.

Method: This is a post-hoc analysis of a prospective multicenter study in which 27 endoscopists, all performing endoscopies for the Dutch screening program, were trained in optical diagnosis. Read More

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December 2018

Psychosocial consequences of living kidney donation: a prospective multicentre study on health-related quality of life, donor-recipient relationships and regret.

Nephrol Dial Transplant 2018 Dec 13. Epub 2018 Dec 13.

Institute of Psychology, Health, Medical and Neuropsychology Unit, Leiden University, Leiden, The Netherlands.

Background: Previous studies have indicated decreased health-related quality of life (HRQoL) shortly after kidney donation, returning to baseline in the longer term. However, a subgroup of donors experiences persistent HRQoL problems. To identify which HRQoL aspects are impacted most by the donation and to identify at-risk donors, more specific insight into psychosocial donation consequences is needed. Read More

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December 2018

Cytokine, chemokine and cytokine receptor changes are associated with metabolic improvements after bariatric surgery.

J Clin Endocrinol Metab 2018 Dec 13. Epub 2018 Dec 13.

Department of Physiology, and Center for Metabolism and Obesity Research, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Context: Altered cytokine levels and chronic low-grade inflammation contributes to metabolic dysfunction in obesity. The extent of cytokine changes and their impact on metabolic improvements following bariatric surgery has not been fully explored.

Objective: To compare 76 circulating cytokines, chemokines, and secreted cytokine receptors in obese and lean subjects, and determine how these cytokines are altered by bariatric surgery. Read More

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December 2018

All-cause mortality among three generations of Moluccans in the Netherlands.

Eur J Public Health 2018 Dec 12. Epub 2018 Dec 12.

Department of Public Health, Academic Medical Center, Amsterdam, The Netherlands.

Background: Mortality variations have been reported for ethnic minority groups compared with their host populations. It is uncertain how this mortality variations change over time as younger generations become older and mix with the host population. This study aimed to examine all-cause mortality among three generations of Moluccans in the Netherlands, and to compare Moluccans with a mixed and non-mixed ethnic background. Read More

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December 2018

Effect of nonmeat, high-protein supplementation on quality of life and clinical outcomes in older residents of care homes: a systematic review and meta-analysis.

Nutr Rev 2018 Dec 13. Epub 2018 Dec 13.

Ageing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom.

Context: Care home residents are at risk of malnutrition owing to reduced food intake, anabolic resistance in aging muscle, and a high prevalence of medical morbidity and functional dependency. There has been limited consensus regarding the effectiveness of a high-protein diet on quality of life or clinical outcomes in care home residents.

Objective: The aim of this review was to evaluate the effectiveness of nonmeat, high-protein supplementation on health-related quality of life (HRQOL) and relevant clinical and nutritional outcomes in older people in a care home setting. Read More

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December 2018

Effects of tofacitinib in early arthritis-induced bone loss in an adjuvant-induced arthritis rat model.

Rheumatology (Oxford) 2018 Dec 12. Epub 2018 Dec 12.

Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.

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December 2018

Characterization of Patients with Ibuprofen Hypersensitivity.

Int Arch Allergy Immunol 2018 Dec 13:1-5. Epub 2018 Dec 13.

Division of Allergy and Clinical Immunology, St. Michael's Hospital, University of Toronto, Toronto, Ontario,

Background: Ibuprofen is the most frequently used over-the-counter nonsteroidal anti-inflammatory drug (NSAID) in North America. While it has been commonly implicated in drug-induced hypersensitivity reactions, there is limited literature specifically on ibuprofen hypersensitivity.

Objectives: To characterize the demographics and clinical course of hypersensitivity reactions in a cohort of patients with ibuprofen allergy. Read More

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December 2018

School effectiveness and students' future orientation: A multilevel analysis of upper secondary schools in Stockholm, Sweden.

J Adolesc 2018 Dec 10;70:62-73. Epub 2018 Dec 10.

Department of Public Health Sciences, Stockholm University, SE-106 91, Stockholm, Sweden. Electronic address:

Introduction: Future orientation (FO) refers to individuals' beliefs and feelings about their future. Earlier research has primarily investigated correlates of FO at the individual and family level, but it seems likely that FO is also shaped by other central agents or institutions, such as the school. Earlier studies have found positive associations between "school effectiveness" and student performance, and negative associations in relation to e. Read More

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December 2018

Environmental surveillance of Legionella spp. colonization in the water system of a large academic hospital: Analysis of the four-year results on the effectiveness of the chlorine dioxide disinfection method.

Sci Total Environ 2018 Dec 5;657:248-253. Epub 2018 Dec 5.

Institute of Public Health, Section of Hygiene, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Roma, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Francesco Vito 1, 00168 Roma, Italy.

The prevention of Legionella colonization of water systems is one of the goals of hospital management. Among chemical disinfection methods, chlorine dioxide (ClO) has been largely used to control Legionella spp. in water systems. Read More

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December 2018

ROS1 gene rearrangements are associated with an elevated risk of peri-diagnosis thromboembolic events.

J Thorac Oncol 2018 Dec 10. Epub 2018 Dec 10.

University of Colorado, Division of Medical Oncology, 12801 E. 17(th) Avenue, 8122, 8th Floor, Aurora, CO 80045, USA.

Introduction: We hypothesized that advanced ROS1 gene-rearranged non-small cell lung cancer (ROS1+ NSCLC) has a higher than expected thromboembolic event (TEE) rate.

Methods: Venous and arterial TEE within +/- 365 days of diagnosis of ROS1+, ALK+, EGFR+ or KRAS+ advanced NSCLC at 5 academic centers in the USA and China were captured (October 2002-April 2018). The primary endpoint was incidence of TEE in ROS1+ compared to ALK+, EGFR+, and KRAS+ NSCLC within +/- 90 days of diagnosis. Read More

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December 2018

Nighttime intensive care unit discharge and outcomes: A propensity matched retrospective cohort study.

PLoS One 2018 13;13(12):e0207268. Epub 2018 Dec 13.

Dept. of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil.

Background: Nighttime ICU discharge, i.e., discharge from the ICU during the night hours, has been associated with increased readmission rates, hospital length of stay (LOS) and in-hospital mortality. Read More

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December 2018

Public health and the radio frequency radiation emitted by cellphone technology, smart meters and WiFi.

Authors:
Susan Pockett

N Z Med J 2018 Dec 14;131(1487):97-107. Epub 2018 Dec 14.

Honorary Academic, School of Psychology, University of Auckland, Auckland.

This paper argues that the prevailing official narrative in New Zealand concerning the relationship between public health and the radio frequency emissions (RF) from cellphone technology, WiFi and electricity smart meters is scientifically and ethically flawed. The main regulatory document in the area, NZS2772.1:1999, is 20 years out of date and ignores existing laboratory evidence disproving its core assumption that the only biological effect of non-ionising radiation is tissue heating. Read More

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December 2018

Quality of Life after Reconstructive Surgery for Intestinal Fistulas.

Acta Medica (Hradec Kralove) 2018 ;61(3):103-107

Department of Gerontology and Metabolism, Teaching Hospital Hradec Králové, Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic.

Background: This retrospective clinical study would like to objectively denote a quality of life of persons afflicted by an abdominal catastrophe and managed by an extensive surgery can be almost as well conformable as those of healthy people in a similar age group.

Methods: A set of eighteen patients who were successfully surgically treated and cured enjoyed a relatively good convalescence after their surgery and returned to a satisfactory standard of life from the point of view of organ function and psychosomatic state. Statistical analysis of the data collected over a period of 1 to 6 years after this complex therapy using special questionnaire for QOL assessment SF-36 was performed. Read More

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January 2018

Histopathology of human small intestinal and colonic ischemia-reperfusion: experiences from human IR-models.

Histol Histopathol 2018 Dec 13:18074. Epub 2018 Dec 13.

NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, the Netherlands.

Intestinal ischemia-reperfusion (IR) injury is a frequent, but potentially life-threatening condition. Although much has been learned about its pathophysiology from animal IR models, the translation to the human setting is imperative for better understanding of its etiology. This could provide us with new insight into development of early detection and potential new therapeutic strategies. Read More

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December 2018