48,328 results match your criteria Abstracts are Not Accepted [Journal]


Active Site Glu165 Activation in Triosephosphate Isomerase and its Deprotonation Kinetics.

J Phys Chem B 2019 Apr 23. Epub 2019 Apr 23.

Triosephosphate isomerase (TIM) catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde 3-phosphate (GAP), via an enediol(ate) intermediate. The active site residue Glu165 serves as the catalytic base during catalysis. It abstracts a proton from C1 carbon of DHAP to form reaction intermediate and donates a proton to C2 carbon of the intermediate to form product GAP. Read More

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http://dx.doi.org/10.1021/acs.jpcb.9b02981DOI Listing

The Use of Cancer-Specific Patient-Centered Technologies Among Underserved Populations in the United States: Systematic Review.

J Med Internet Res 2019 Apr 23;21(4):e10256. Epub 2019 Apr 23.

VA Health Services Research and Development, Center for Health Information & Communication, Richard L Roudebush VA Medical Center, Indianapolis, IN, United States.

Background: In the United States, more than 1.6 million new cases of cancer are estimated to be diagnosed each year. However, the burden of cancer among the US population is not shared equally, with racial and ethnic minorities and lower-income populations having a higher cancer burden compared with their counterparts. Read More

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http://dx.doi.org/10.2196/10256DOI Listing

[Changes in the scales "attachment" and "control" of the OPD-KJ "structure" axis for inpatients of a pediatric and adolescent psychiatric clinic].

Z Kinder Jugendpsychiatr Psychother 2019 Apr 23:1-14. Epub 2019 Apr 23.

2 Klinik Sonnenhof, Kinder- und Jugendpsychiatrisches Zentrum, Ganterschwil.

Changes in the scales "attachment" and "control" of the OPD-KJ "structure" axis for inpatients of a pediatric and adolescent psychiatric clinic Abstracts: Despite the great importance of structural deficits in adolescent patients, studies on changes that occur in the course of their inpatient psychiatric treatment are lacking. This study assesses the effectiveness of inpatient psychodynamic psychotherapy, the scales "attachment" and "control" of the "structure" axis of Operationalized Psychodynamic Diagnostics in Childhood and Adolescence (OPD-KJ). The study was carried out by dual case leaders (psychotherapist and pedagogue/nurse) on 75 patients (12-18 years) at the beginning and at end of 8 weeks of therapy. Read More

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http://dx.doi.org/10.1024/1422-4917/a000660DOI Listing

Understanding the Mentoring Environment Through Thematic Analysis of the Learning Environment in Medical Education: a Systematic Review.

J Gen Intern Med 2019 Apr 22. Epub 2019 Apr 22.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Mentoring's success has been attributed to individualised matching, holistic mentoring relationships (MRs) and personalised mentoring environments (MEs). Whilst there is growing data on matching and MRs, a dearth of ME data has hindered development of mentoring programme. Inspired by studies likening MEs to learning environments (LEs) and data highlighting common characteristics between the two, this systematic review scrutinises reports on LEs to extrapolate the findings to the ME context to provide a better understanding of ME and their role in the mentoring process. Read More

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http://dx.doi.org/10.1007/s11606-019-05000-yDOI Listing

The Burden of Dysphagia on Family Caregivers of the Elderly: A Systematic Review.

Geriatrics (Basel) 2018 Jun 10;3(2). Epub 2018 Jun 10.

Communication Disorders and Sciences, University of Oregon, Eugene, OR 97403, USA.

With the rapid increase in the elderly population, there is a simultaneous increased need for care provided by family caregivers. Research in the field of head and neck cancer has indicated that caring for patients with dysphagia can impact a caregiver's quality of life. Given that many older adults present with dysphagia, one can assume that their caregivers are equally, if not more greatly, affected. Read More

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http://dx.doi.org/10.3390/geriatrics3020030DOI Listing

Prophylactic antibiotic regimens in dental implant failure: A systematic review and meta-analysis.

J Am Dent Assoc 2019 Apr 19. Epub 2019 Apr 19.

Background: In this systematic review and meta-analysis, the authors examine the efficacy of antibiotic prophylaxis (AP) and specific antibiotic regimens for prevention of dental implant failure in patients who are healthy overall.

Types Of Studies Reviewed: The authors independently conducted electronic database and manual searches to identify randomized controlled trials (RCTs). The authors selected articles on the basis of eligibility criteria and assessed for risk of bias by using the Cochrane Handbook. Read More

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http://dx.doi.org/10.1016/j.adaj.2018.10.015DOI Listing

Interventions for improved diabetes control and self-management among those experiencing homelessness: protocol for a mixed methods scoping review.

Syst Rev 2019 Apr 22;8(1):100. Epub 2019 Apr 22.

Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 30 Bond Street, Toronto, ON, M5B 1W8, Canada.

Background: Diabetes is a chronic medical condition that requires patients to be actively engaged in intensive self-management to achieve optimal clinical outcomes. Unfortunately, individuals who are experiencing homelessness often struggle to manage diabetes and consequently suffer numerous and severe complications-both acute and chronic. There are many barriers to optimal diabetes self-management among this population, and this may be exacerbated by the lack of tailoring and customization of care to this unique population. Read More

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http://dx.doi.org/10.1186/s13643-019-1020-xDOI Listing

The risk of malignancy in uterine polyps: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2019 Apr 15;237:48-56. Epub 2019 Apr 15.

Department of Woman, Newborn and Child, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Università degli studi di Milano, Milan, Italy. Electronic address:

Background: Endometrial polyps are a common condition. The risk of malignancy has often led to an overtreatment with high health care costs and huge psychological distress.

Objective: We conducted a systematic review and a meta-analysis in order to estimate the prevalence of premalignant and malignant lesions in women undergoing hysteroscopic polypectomy. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2019.04.009DOI Listing

Stabilizing Terminal Ni(III)-Hydroxide Complex Using NNN-Pincer Ligands: Synthesis and Characterization.

Inorg Chem 2019 Apr 22. Epub 2019 Apr 22.

Department of Chemistry , Indian Institute of Technology Bombay , Powai - 400076 , Mumbai , Maharashtra , India.

The reaction of [Ni(COD)] (COD; cyclooctadiene) in THF with the NNN-pincer ligand bis(imino)pyridyl (L) reveals a susceptibility to oxidation in an inert atmosphere ([O] level <0.5 ppm), resulting in a transient Ni:dioxygen adduct. This reactive intermediate abstracts a hydrogen atom from THF and stabilizes an uncommon Ni(III) complex. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00466DOI Listing

Efficacy of sertraline for post-stroke depression: A systematic review protocol of randomized controlled trial.

Medicine (Baltimore) 2019 Apr;98(16):e15299

Second Ward of Neurology Department, Cardiovascular and Cerebrovascular Specialist Section of Yan'an University Affiliated Hospital, Yan'an, China.

Background: Depression is a prevalent disorder for patients with stroke. Clinical researches indicate that sertraline is utilized to treat post-stroke depression (PSD) effectively. However, no systematic review has investigated this issue yet presently. Read More

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http://dx.doi.org/10.1097/MD.0000000000015299DOI Listing

Efficacy of rivaroxaban for pulmonary embolism.

Medicine (Baltimore) 2019 Apr;98(16):e15224

Department of Critical Medicine, Yulin No. 2 Hospital, Yulin, Shaanxi, China.

Background: Previous clinical trials have addressed that rivaroxaban is effective for the treatment of patients with pulmonary embolism (PE). This study will systematically assess its efficacy and safety for PE.

Methods: We will carry out this study by searching the following electronic databases from inception to March 1, 2019 without language restrictions: Cochrane Library, EMBASE, PUBMED, Web of Science, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. Read More

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http://dx.doi.org/10.1097/MD.0000000000015224DOI Listing

Impact of full field digital mammography diagnosis for female patients with breast cancer.

Medicine (Baltimore) 2019 Apr;98(16):e15175

Department of Computed Tomography, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Background: Previous clinical studies have reported that full field digital mammography (FFDM) can be used for diagnosis on breast cancer (BC) with promising outcome results. However, no study systematically investigates its diagnostic impact on female patients with BC. Thus, this systematic review will assess the accurate of FFDM diagnosis on BC. Read More

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http://dx.doi.org/10.1097/MD.0000000000015175DOI Listing

The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review.

JMIR Res Protoc 2019 Apr 22;8(4):e12045. Epub 2019 Apr 22.

Bristol-Myers Squibb, Uxbridge, United Kingdom.

Background: Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of vitamin D in clinical and laboratory improvements in MS patients.

Objective: The aim of this systematic review protocol is to evaluate the efficacy of vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles. Read More

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http://dx.doi.org/10.2196/12045DOI Listing

Intrapleural Tissue Plasminogen Activator for Traumatic Retained Hemothorax.

Ann Pharmacother 2019 Apr 21:1060028019846122. Epub 2019 Apr 21.

1 The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Objective: To describe the efficacy, safety, dosing regimen, and administration technique of intrapleural alteplase for the treatment of retained hemothorax.

Data Sources: A PubMed, EMBASE, and Google Scholar search (January 2000 to February 2019) was conducted with the search terms intrapleural, fibrinolytic, fibrinolysis, alteplase, tissue plasminogen activator, and hemothorax.

Study Selection And Data Extraction: Articles were included if they described the use of intrapleural alteplase in adult patients with a retained hemothorax; single patient case reports and abstracts were excluded. Read More

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http://dx.doi.org/10.1177/1060028019846122DOI Listing

HIVR4P 2018: From Research to Impact.

AIDS Res Hum Retroviruses 2019 Apr 22. Epub 2019 Apr 22.

International AIDS Society, 503988, Geneva, Switzerland ;

The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners and community workers from different fields and geographic areas. The conference theme in 2018, "From Research to Impact", acknowledged an increasing focus on translation of promising research findings into practical, accessible and affordable HIV prevention options for those who need them worldwide. HIVR4P 2018 was held in Madrid, Spain, on 21-25 October, with over 1,400 participants from 52 countries around the globe, representing all aspects of HIV prevention research and implementation. Read More

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http://dx.doi.org/10.1089/AID.2019.0074DOI Listing

Prevalence and etiology of elbow flexion contractures in brachial plexus birth injury: A scoping review.

J Pediatr Rehabil Med 2019 ;12(1):75-86

Rehabilitation Sciences Institute, University of Toronto, Toronto, ON, Canada.

Purpose: To synthesize the evidence on the prevalence and etiology of elbow flexion contractures secondary to brachial plexus birth injury (BPBI).

Methods: Using Arksey and O'Malley's scoping review framework, MEDLINE, EMBASE, PsycINFO, and CINAHL databases were searched, followed by a comprehensive grey literature search. Articles and abstracts of studies of all level of evidence on the prevalence, natural history, clinical presentation, etiology, and treatment of elbow flexion contractures in BPBI were included. Read More

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http://dx.doi.org/10.3233/PRM-180535DOI Listing
January 2019

International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
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The utility of diagnostic selective nerve root blocks in the management of patients with lumbar radiculopathy: a systematic review.

BMJ Open 2019 Apr 20;9(4):e025790. Epub 2019 Apr 20.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Objective: Lumbar radiculopathy (LR) often manifests as pain in the lower back radiating into one leg (sciatica). Unsuccessful back surgery is associated with significant healthcare costs and risks to patients. This review aims to examine the diagnostic accuracy of selective nerve root blocks (SNRBs) to identify patients most likely to benefit from lumbar decompression surgery. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025790DOI Listing

Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis.

BMJ Open 2019 Apr 20;9(4):e024343. Epub 2019 Apr 20.

Sanofi Pasteur, Inc., Swiftwater, Pennsylvania, USA.

Objective: carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by age group and world region from 2007 to 2016.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024343DOI Listing

[Influence of post-traumatic stress disorder on asthma].

Presse Med 2019 Apr 17. Epub 2019 Apr 17.

Université de Poitiers, centre hospitalier Henri-Laborit, unité de recherche clinique, 86021 Poitiers, France.

Introduction: Exposure to a traumatic event may not only lead to a large variety of mental disorders, such as post-traumatic stress disorder (PTSD) but also respiratory symptoms and/or respiratory diseases, as asthma.

Objectives: Systematic literature review of data on the impact of post-traumatic stress disorder on asthma.

Documentary Sources: Medline, on the period 1980-2018 with the following keywords: "PTSD" or "post-traumatic stress disorder" or "post-traumatic stress disorder" and "asthma", limits "title/abstract"; the selected languages were English or French. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.03.002DOI Listing

UK Public Health Science 2019: a call for abstracts.

Lancet 2019 Apr 17. Epub 2019 Apr 17.

Institute of Health Informatics, University College London, London, UK.

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http://dx.doi.org/10.1016/S0140-6736(19)30895-5DOI Listing

Invited review: Completeness of reporting of experiments: REFLECTing on a year of animal trials in the Journal of Dairy Science.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G 2W1, Canada.

Reproducibility is an essential element of the scientific process, and it requires clear and complete reporting of study design, conduct, and analysis. In the human and animal health literature, incomplete reporting is associated with biased effect estimates. Moreover, incomplete reporting precludes knowledge synthesis and undervalues the resources allocated to the primary research. Read More

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http://dx.doi.org/10.3168/jds.2018-15797DOI Listing

Differences in the kinematics of the cervical and thoracic spine during functional movement in individuals with or without chronic neck pain: a systematic review.

Physiotherapy 2019 Jan 21. Epub 2019 Jan 21.

Health Sciences (Physiotherapy), University of Newcastle, Newcastle, Australia. Electronic address:

Background: Chronic neck pain is common, impacting a person's ability to complete functional tasks. One method of quantifying functional movement is three dimensional (3D) motion analysis, however, it is unknown whether it may detect alterations in movement kinematics in individuals with neck pain.

Objective: To systematically review studies to determine possible differences in cervical and thoracic kinematics during functional movement as measured by 3D motion analysis in individuals with neck pain compared to controls. Read More

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http://dx.doi.org/10.1016/j.physio.2019.01.007DOI Listing
January 2019

Meta-Analysis: 13-Year Follow-Up of Psychotherapy Effects on Youth Depression.

J Am Acad Child Adolesc Psychiatry 2019 Apr 17. Epub 2019 Apr 17.

Objective: Youth depression is a debilitating condition that constitutes a major public health concern. A 2006 meta-analysis found modest benefits for psychotherapy vs. control. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08908567193026
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http://dx.doi.org/10.1016/j.jaac.2019.04.002DOI Listing
April 2019
2 Reads

A systematic review of measures of therapist competence in psychodynamic, interpersonal, and/or relational models.

Psychol Psychother 2019 Apr 19. Epub 2019 Apr 19.

Centre for New Treatments and Understanding in Mental Health (CeNTrUM), School of Health Sciences, University of Manchester, UK.

Purpose: Assessment of psychotherapeutic competence is increasingly regarded as important in the delivery of psychological services and training programmes. This article reviews tools designed to assess clinical competence in psychodynamic, interpersonal, and relational models of therapy.

Methods: PsycINFO, CINAHL, and Web of Science online databases were reviewed using terms relating to competence, psychotherapy, and measurement. Read More

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http://dx.doi.org/10.1111/papt.12231DOI Listing
April 2019
1 Read

Use of Immunosuppressive therapy for management of myelodysplastic syndromes: a systematic review and meta-analysis.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Department of Internal Medicine, Section of Hematology, Yale School of Medicine;

Immunosuppressive therapy is one therapy option for treatment of patients with lower-risk myelodysplastic syndromes. However, the use of several different immunosuppressive regimens, the lack of high-quality studies, and the absence of validated predictive biomarkers pose important challenges. We conducted a systematic review and meta-analysis according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines and searched MEDLINE via PubMed, Ovid EMBASE, COCHRANE registry of clinical trials (CENTRAL), and the Web of Science without language restriction from inception through September 2018 as well as relevant conference proceedings and abstracts. Read More

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http://dx.doi.org/10.3324/haematol.2019.219345DOI Listing

Rapidly decreasing prevalence of Helicobacter pylori among Japanese children and adolescents.

J Infect Chemother 2019 Apr 16. Epub 2019 Apr 16.

Department of Public Health, Aichi Medical University School of Medicine, Japan. Electronic address:

Background: The secular trend in the prevalence of Helicobacter pylori (H. pylori) infection among children and adolescents in Japan has not been well documented.

Materials And Methods: We reviewed all relevant literature published between 1991 and 2017, focusing on the relationship between the prevalence of H. Read More

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http://dx.doi.org/10.1016/j.jiac.2019.02.016DOI Listing

The effectiveness of group exercise for improving activity and participation in adult stroke survivors: a systematic review.

Physiotherapy 2019 Jan 19. Epub 2019 Jan 19.

School of Health and Related Research (ScHARR), University of Sheffield, Regent Court, 30 Regent Street, Sheffield, South Yorkshire S14DA, United Kingdom. Electronic address:

Background: Following post stroke rehabilitation, group exercise interventions can be used to continue improving cardiovascular fitness, activity levels, balance, gait, movement efficiency, and strengthening. However, little is known of the effectiveness of group exercise for improving activity and participation in stroke survivors.

Objectives: This review aims to assess the effectiveness of group exercise for improving activity and participation in adult stroke survivors. Read More

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http://dx.doi.org/10.1016/j.physio.2019.01.005DOI Listing
January 2019

Augmented and virtual reality in dental medicine: A systematic review.

Comput Biol Med 2019 Mar 15;108:93-100. Epub 2019 Mar 15.

Department of Reconstructive Dentistry, University Center for Dental Medicine Basel, University of Basel, Switzerland, Hebelstr. 3, CH-4056, Basel, Switzerland.

Background: The aim of this systematic review was to provide an update on the contemporary knowledge and scientific development of augmented reality (AR) and virtual reality (VR) in dental medicine, and to identify future research needs to accomplish its clinical translation.

Method: A modified PICO-strategy was performed using an electronic (MEDLINE, EMBASE, CENTRAL) plus manual search up to 12/2018 exploring AR/VR in dentistry in the last 5 years. Inclusion criteria were limited to human studies focusing on the clinical application of AR/VR and associated field of interest in dental medicine. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00104825193008
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http://dx.doi.org/10.1016/j.compbiomed.2019.03.012DOI Listing
March 2019
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Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011385. Epub 2019 Apr 19.

Van Creveldkliniek / Department of Haematology, University Medical Centre Utrecht, Heidelberglaan 100, Utrecht, Netherlands, 3584CT.

Background: Minor oral surgery or dental extractions (oral or dental procedures) are widely performed and can be complicated by hazardous oral bleeding, especially in people with an inherited bleeding disorder such as haemophilia or Von Willebrand disease (VWD). The amount and severity of singular bleedings depend on disease-related factors, such as the severity of the haemophilia, both local and systemic patient factors (such as periodontal inflammation, vasculopathy or platelet dysfunction) and intervention-related factors (such as the type and number of teeth extracted or the dimension of the wound surface). Similar to local haemostatic measures and suturing, antifibrinolytic therapy is a cheap, safe and potentially effective treatment to prevent bleeding complications in individuals with bleeding disorders undergoing oral or dental procedures. Read More

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http://doi.wiley.com/10.1002/14651858.CD011385.pub3
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http://dx.doi.org/10.1002/14651858.CD011385.pub3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6474399PMC
April 2019
2 Reads

A Systematic Review of Right Ventricular Diastolic Assessment by 4D Flow CMR.

Biomed Res Int 2019 14;2019:6074984. Epub 2019 Mar 14.

Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.

Background: Four-dimensional flow cardiovascular magnetic resonance (4D flow CMR) is a noninvasive novel imaging technology that can be used to visualise and assess right ventricular function. The aim of this systematic review is to summarise the literature available on 4D flow CMR methods used to determine right ventricular diastolic function.

Methods: A systematic review of current literature was carried out to ascertain what is known about right ventricular assessment by quantification of 4D flow CMR. Read More

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https://www.hindawi.com/journals/bmri/2019/6074984/
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http://dx.doi.org/10.1155/2019/6074984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437735PMC
March 2019
1 Read

2019 Annual Session Semifinalists? Research Abstracts.

Authors:

Pediatr Dent 2019 Mar;41(2):152-156

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Understanding patient engagement in health system decision-making: a co-designed scoping review.

Syst Rev 2019 Apr 18;8(1):97. Epub 2019 Apr 18.

The Department Community Health Sciences, Teaching Research and Wellness Building, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada.

Background: With healthcare striving to shift to a more person-centered delivery model, patient and family involvement must have a bigger role in shaping this. While many initiatives involving patients and family members focus on self-care, a broader understanding of patient participation is necessary. Ensuring a viable and sustainable critical number of qualified patients and family members to support this shift will be of utmost importance. Read More

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https://systematicreviewsjournal.biomedcentral.com/articles/
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http://dx.doi.org/10.1186/s13643-019-0994-8DOI Listing
April 2019
4 Reads

Social capital components and social support of persons with multiple sclerosis: a systematic review of the literature from 2000 to 2018.

Disabil Rehabil 2019 Apr 18:1-13. Epub 2019 Apr 18.

c Neurology, Public Health, Disability Unit and Coma Research Centre , Fondazione IRCCS Istituto Neurologico Carlo Besta , Milan , Italy.

Purpose: To identify experiences of persons with multiple sclerosis (MS) in terms of social capital and its components (i.e., social networks, trust, and interpersonal relationships) and social support based on the current scientific knowledge. Read More

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http://dx.doi.org/10.1080/09638288.2019.1597182DOI Listing

Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma.

Cochrane Database Syst Rev 2019 Apr 19;4:CD011875. Epub 2019 Apr 19.

Ophthalmology, Singapore National Eye Centre, Singapore, Singapore.

Background: Glaucoma affects more than 70 million people worldwide, with about 10% being bilaterally blind, making it the leading cause of irreversible blindness globally. In patients with advanced glaucoma or those who have failed medical treatment without achieving adequate intraocular pressure (IOP) control, trabeculectomy (glaucoma filtration surgery where an ostium is created into the anterior chamber from underneath a partial thickness scleral flap to allow for aqueous flow out of the anterior chamber intointo the subconjunctival space forming a filtering bleb) and aqueous shunt surgery for more complex and refractory cases remain the mainstay therapies. Proliferation of fibrous tissue around an implanted aqueous shunt may block the diffusion of aqueous humour. Read More

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http://doi.wiley.com/10.1002/14651858.CD011875.pub2
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http://dx.doi.org/10.1002/14651858.CD011875.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472957PMC
April 2019
1 Read

Child sexual abuse, disclosure and PTSD: A systematic and critical review.

Child Abuse Negl 2019 Apr 15;92:196-208. Epub 2019 Apr 15.

Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.

Background: Child sexual abuse (CSA) is a prevalent exposure with potentially serious, negative health consequences, including post-traumatic stress disorder (PTSD) and its symptomatology.

Objective: To conduct a systematic and critical review in order to investigate the relationship between CSA disclosure patterns and PTSD.

Participants And Setting: Studies included clinical, college and community-based samples of adults' and children's experiences of CSA. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01452134193013
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http://dx.doi.org/10.1016/j.chiabu.2019.04.006DOI Listing
April 2019
1 Read

Detecting pathological complete response in esophageal cancer after neoadjuvant therapy based on imaging techniques: a diagnostic systematic review and meta-analysis.

J Thorac Oncol 2019 Apr 15. Epub 2019 Apr 15.

Department of surgery.

Background: Up to 32% of patients with esophageal cancer show a pathological complete response (ypCR) after neoadjuvant therapy. In order to prevent overtreatment, the indication to perform esophagectomy in these patients should be reconsidered. Implementing an organ preserving strategy for patients with ypCR requires an accurate assessment of residual disease after neoadjuvant treatment. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.004DOI Listing
April 2019
1 Read

Incidence and factors associated with substance abuse and patient-related violence in the emergency department: A literature review.

Australas Emerg Care 2018 Nov 2;21(4):159-170. Epub 2018 Nov 2.

Austin Clinical School of Nursing, La Trobe University, Heidelberg, Victoria, Australia.

Background: The level of workplace violence in emergency departments worldwide has reached an alarming level. Substance abuse is thought to play a major part in the escalation of aggressive and violent behaviour and is suspected to be responsible for the majority of violent escalations in the emergency department. The aim of this scoping review was (1) to investigate the incidence of workplace violence in the emergency department, their association to substance abuse and (2) to identify factors associated with workplace violence such as perpetrator characteristics and environmental factors. Read More

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http://dx.doi.org/10.1016/j.auec.2018.10.004DOI Listing
November 2018
1 Read

Metformin and second- or third-generation sulphonylurea combination therapy for adults with type 2 diabetes mellitus.

Cochrane Database Syst Rev 2019 Apr 18;4:CD012368. Epub 2019 Apr 18.

Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, Denmark, 2200.

Background: The number of people with type 2 diabetes mellitus (T2DM) is increasing worldwide. The combination of metformin and sulphonylurea (M+S) is a widely used treatment. Whether M+S shows better or worse effects in comparison with other antidiabetic medications for people with T2DM is still controversial. Read More

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http://dx.doi.org/10.1002/14651858.CD012368.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472662PMC

Defining Frailty in Research Abstracts: A Systematic Review and Recommendations for Standardization.

J Frailty Aging 2019 ;8(2):67-71

Ariela R. Orkaby, MD MPH, Instructor in Medicine, Harvard Medical School, Geriatric Research, Education and Clinical Center, VA Boston Healthcare System, 150 South Huntington St, Boston, MA 02130 USA, Phone: 857-364-3646; Fax: 857-364-2784, Email:

Multiple definitions of frailty are used. We sought to quantify the frequency that frailty is insufficiently defined in published abstracts. We conducted a systematic review of MEDLINE/PubMed for English abstracts of original research investigating frailty as an exposure or outcome in humans from 2015-2017. Read More

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http://dx.doi.org/10.14283/jfa.2019.4DOI Listing
January 2019
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Systematic Review of Lesser Known Parasitoses: Maxillofacial Dirofilariasis.

J Maxillofac Oral Surg 2019 Jun 2;18(2):180-189. Epub 2018 Aug 2.

6Department of Pathology, AIIMS Jodhpur, Jodhpur, India.

Background: Dirofilariasis is an endemic disease in tropical and subtropical countries caused by about 40 different species of dirofilari. Dirofilariasis of the oral cavity is extremely rare and is usually seen as mucosal or submucosal nodules. We also present a case of dirofilariasis of the mandibular third molar region submucosally in a 26 year old male patient. Read More

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http://dx.doi.org/10.1007/s12663-018-1139-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441424PMC

Virologic failure and HIV drug resistance on simplified, dolutegravir-based maintenance therapy: Systematic review and meta-analysis.

F1000Res 2018 30;7:1359. Epub 2018 Aug 30.

Division of Infectious Diseases, Geneva University Hospital, Geneva, 1205, Switzerland.

Dolutegravir-containing maintenance therapy is a promising simplification strategy for virologically suppressed HIV-infected individuals. However, most of the available data to inform this strategy come from small, uncontrolled studies. We estimated the proportion of HIV-infected patients experiencing virological failure (VF) and developing drug resistance on dolutegravir (DTG)-based maintenance therapy. Read More

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https://f1000research.com/articles/7-1359/v1
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http://dx.doi.org/10.12688/f1000research.15995.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134332.2PMC
August 2018
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Guidelines for Postoperative care in Cesarean Delivery: Enhanced Recovery After Surgery (ERAS) Society Recommendations (Part 3 ).

Am J Obstet Gynecol 2019 Apr 14. Epub 2019 Apr 14.

Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, United States.

This Enhanced Recovery After Surgery (ERAS) Guideline for postoperative care in Cesarean Delivery (CD) will provide best practice, evidenced-based, recommendations for post-operative care with, primarily a maternal focus. The pathway process for scheduled and unscheduled CD, for this ERAS CD guideline, will consider time from completion of cesarean until maternal hospital discharge. The literature search (1966-2017) used Embase and PubMed to search medical subject headings including "Cesarean Section", "Cesarean Delivery", "Cesarean Section Delivery" and all post-operative ERAS® items. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029378193057
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http://dx.doi.org/10.1016/j.ajog.2019.04.012DOI Listing
April 2019
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Coverage of ethics within the artificial intelligence and machine learning academic literature: The case of disabled people.

Assist Technol 2019 Apr 17:1-7. Epub 2019 Apr 17.

a Community Rehabilitation and Disability Studies, Department of Community Health Sciences, Cumming School of Medicine , University of Calgary , Calgary , Alberta , Canada.

Disabled people are often the anticipated users of scientific and technological products and processes advanced and enabled by artificial intelligence (AI) and machine learning (ML). Disabled people are also impacted by societal impacts of AI/ML. Many ethical issues are identified within AI/ML as fields and within individual applications of AI/ML. Read More

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http://dx.doi.org/10.1080/10400435.2019.1593259DOI Listing

Mechanistic study of the reaction of CHF with Cl atoms in the absence and presence of CH or CH: decomposition of CHFOH and fate of the CHFO radical.

Phys Chem Chem Phys 2019 Apr 17. Epub 2019 Apr 17.

Department of Chemical Engineering, University of Melbourne, Victoria 3010, Australia.

To assess the atmospheric fate of fluorinated compounds, chamber experiments were performed with Fourier transform infrared spectroscopy investigating the products of difluoromethane, CH2F2, at 296 ± 2 K. The reactions were initiated by reaction of CH2F2 with Cl atoms in the absence and presence of CH4 or C2H6 in air or O2. No evidence of formation of the fluorinated alcohol, CHF2OH, from the reactions of the CHF2O2 radical with either CH3O2 or CH3CH2O2 was observed. Read More

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http://dx.doi.org/10.1039/c8cp06425cDOI Listing

Linking Bisphenol S to Adverse Outcome Pathways Using a Combined Text Mining and Systems Biology Approach.

Environ Health Perspect 2019 Apr;127(4):47005

1 University Paris Descartes , ComUE Sorbonne Paris Cité, Paris, France.

Background: Available toxicity data can be optimally interpreted if they are integrated using computational approaches such as systems biology modeling. Such approaches are particularly warranted in cases where regulatory decisions have to be made rapidly.

Objectives: The study aims at developing and applying a new integrative computational strategy to identify associations between bisphenol S (BPS), a substitute for bisphenol A (BPA), and components of adverse outcome pathways (AOPs). Read More

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https://ehp.niehs.nih.gov/doi/10.1289/EHP4200
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http://dx.doi.org/10.1289/EHP4200DOI Listing
April 2019
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