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    Constructing Genetic Networks using Biomedical Literature and Rare Event Classification.
    Sci Rep 2017 Nov 17;7(1):15784. Epub 2017 Nov 17.
    Department of Physics, Khalifa University of Science and Technology, P.O. Box 127788, Abu Dhabi, UAE.
    Text mining has become an important tool in bioinformatics research with the massive growth in the biomedical literature over the past decade. Mining the biomedical literature has resulted in an incredible number of computational algorithms that assist many bioinformatics researchers. In this paper, we present a text mining system called Gene Interaction Rare Event Miner (GIREM) that constructs gene-gene-interaction networks for human genome using information extracted from biomedical literature. Read More

    Trial registration in pediatric surgery trials.
    J Pediatr Surg 2017 Oct 23. Epub 2017 Oct 23.
    Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Canada; Seneca, School of Biological Sciences and Applied Chemistry, Toronto, Canada. Electronic address:
    Background: Prospective clinical trial registration serves to increase transparency and to mitigate selective reporting bias. An assessment of adult surgical trials revealed poor trial registration practice with incomplete provision of information in registries and inconsistent information in the corresponding publication. The extent and completeness of pediatric surgical trial registration are unknown. Read More

    Current Impact and Application of Abuse-Deterrent Opioid Formulations in Clinical Practice.
    Pain Physician 2017 Nov;20(7):E1003-E1023
    Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan; Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
    Background: Abuse-deterrent formulations (ADFs) represent one novel strategy for curbing the potential of opioid abuse.

    Objective: We aim to compare and contrast the characteristics and applications of current abuse-deterrent opioid products in clinical practice.

    Methods: Literature searches were conducted in databases (Pubmed Medline, International Pharmaceutical Abstracts, Google Scholar) and official reports. Read More

    Mapping the Association between Vitamin D and Low Back Pain: A Systematic Review and Meta-Analysis of Observational Studies.
    Pain Physician 2017 Nov;20(7):611-640
    Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, Sydney, Australia.
    Background: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. Read More

    Music-Induced Analgesia in Chronic Pain Conditions: A Systematic Review and Meta-Analysis.
    Pain Physician 2017 Nov;20(7):597-610
    Universidad Nacional Autónoma de México, Mexico City, Mexico.
    Background: Music is increasingly used as an adjuvant for the management of chronic pain (CP), as it is non-invasive, inexpensive, and patients usually report positive experiences with it. However, little is known about its clinical efficacy in chronic pain patients.

    Objectives: We aimed to determine the effect of music as an adjuvant for chronic pain, as well as to identify characteristics of music interventions associated with positive clinical outcomes. Read More

    Role of Transforming Growth Factor β in Uterine Fibroid Biology.
    Int J Mol Sci 2017 Nov 17;18(11). Epub 2017 Nov 17.
    First Department of Obstetrics and Gynecology, The Centre of Postgraduate Medical Education, 00-416 Warsaw, Poland.
    Uterine fibroids (UFs) are benign tumors of the female genital tract made of the smooth muscle of the uterus. UF growth depends mostly on the influence of the steroid hormones and selected growth factors. Transforming growth factor β (TGF-βs) is a polypeptide that consists of three isoforms: TGF-β1, TGF-β2, and TGF-β3. Read More

    Food Safety at Farmers' Markets: A Knowledge Synthesis of Published Research.
    J Food Prot 2017 Nov 17:2033-2047. Epub 2017 Nov 17.
    2 National Microbiology Laboratory, Public Health Agency of Canada, 160 Research Lane, Suite 206, Guelph, Ontario, Canada N1G 5B2.
    Farmers' markets are increasingly popular venues in North America for the sale of fresh produce and other foods. However, the nature of their operation can present possible food safety issues, challenges, and risks to consumers. A knowledge synthesis was conducted to identify, characterize, and summarize published research on the microbial food safety issues and implications associated with farmers' markets. Read More

    Executive summary of the 12th HHT international scientific conference.
    Angiogenesis 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pulmonology, St. Antonius Hospital, Koekoekslaan 1, 3435 CM, Nieuwegein, The Netherlands.
    Hereditary hemorrhagic telangiectasia is an autosomal dominant trait affecting approximately 1 in 5000 people. A pathogenic DNA sequence variant in the ENG, ACVRL1 or SMAD4 genes, can be found in the majority of patients. The 12th International Scientific HHT Conference was held on June 8-11, 2017 in Dubrovnik, Croatia to present and discuss the latest scientific achievements, and was attended by over 200 scientific and clinical researchers. Read More

    Use of lipid-lowering medicinal herbs during pregnancy: A systematic review on safety and dosage.
    ARYA Atheroscler 2017 May;13(3):135-155
    Professor, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
    Background: Hyperlipidemia is one of the important diseases in pregnancy that causes fetal abnormalities during pregnancy and after the birth. Unfortunately, the usual anti-fat drugs are associated with high morbidity in fetus and due to people's inclination towards taking herbs, it is required to identify side effects of medicinal herbs in pregnancy. The aim of this study was to present hypolipidemic herbs that would not any complications for mother and fetus. Read More

    Prevalence of diabetic retinopathy in children and young people living with diabetes: protocol for a systematic review.
    BMJ Open 2017 Nov 15;7(11):e018578. Epub 2017 Nov 15.
    GOS Institute of Child Health, University College London, London, UK.
    Introduction: The frequency of diabetes mellitus in childhood is increasing. Thus, more children and young people are at risk of developing diabetic retinopathy and diabetes related visual impairment. However, there is no consensus on optimal screening strategies for the paediatric population reflecting the lack of clarity about the current burden of disease in this group. Read More

    Burnout in medical students: a systematic review of experiences in Chinese medical schools.
    BMC Med Educ 2017 Nov 16;17(1):217. Epub 2017 Nov 16.
    School of Public Health, University of New South Wales, Samuels Building, Sydney, NSW, 2052, Australia.
    Background: To identify the: extent to which medical students in China experience burnout; factors contributing to this; potential solutions to reduce and prevent burnout in this group; and the extent to which the experiences of Chinese students reflect the international literature.

    Methods: Systematic review and narrative synthesis. Key words, synonyms and subject headings were used to search five electronic databases in addition to manual searching of relevant journals. Read More

    iPTMnet: an integrated resource for protein post-translational modification network discovery.
    Nucleic Acids Res 2017 Nov 14. Epub 2017 Nov 14.
    Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE 19711, USA.
    Protein post-translational modifications (PTMs) play a pivotal role in numerous biological processes by modulating regulation of protein function. We have developed iPTMnet ( for PTM knowledge discovery, employing an integrative bioinformatics approach-combining text mining, data mining, and ontological representation to capture rich PTM information, including PTM enzyme-substrate-site relationships, PTM-specific protein-protein interactions (PPIs) and PTM conservation across species. Read More

    Treatment of Alcohol-Induced Psychotic Disorder (Alcoholic Hallucinosis)-A Systematic Review.
    Alcohol Alcohol 2017 Nov 14:1-9. Epub 2017 Nov 14.
    Betsi Cadwaladr University Health Board (BCUHB), Heddfan Unit, Wrexham Maelor Hospital, Wrexham, Wales LL13 7TD, UK.
    Aims: To evaluate the effectiveness of evidence based treatments for alcohol-induced psychotic disorder (AIPD) as described by ICD-10 and DSM-5, a condition that is distinct from schizophrenia and has a close relationship with alcohol withdrawal states.

    Method: Systematic review using PRISMA guidelines.

    Results: Of 6205 abstracts found, fifteen studies and ten case reports met criteria and were examined. Read More

    A model-guided symbolic execution approach for network protocol implementations and vulnerability detection.
    PLoS One 2017 16;12(11):e0188229. Epub 2017 Nov 16.
    College of Electronic Science and Engineering, National University of Defense Technology, Changsha, China.
    Formal techniques have been devoted to analyzing whether network protocol specifications violate security policies; however, these methods cannot detect vulnerabilities in the implementations of the network protocols themselves. Symbolic execution can be used to analyze the paths of the network protocol implementations, but for stateful network protocols, it is difficult to reach the deep states of the protocol. This paper proposes a novel model-guided approach to detect vulnerabilities in network protocol implementations. Read More

    Exploring the Association between Statin Use and the Risk of Parkinson's Disease: A Meta-Analysis of Observational Studies.
    Neuroepidemiology 2017 Nov 16;49(3-4):142-151. Epub 2017 Nov 16.
    Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
    Background: Parkinson's disease (PD) is a progressive disorder of the central nervous system. The prevalence of PD varies considerably by age group; it has a higher prevalence in patients aged 60 years and more. Several studies have shown that statin, a cholesterol-lowering medication, reduces the risk of developing PD, but evidence for this is so far inconclusive. Read More

    Report from the BIT's 1st Annual World Congress of Biomedical Engineering Held in Xi'an, China, 9-11 November 2017.
    Medicines (Basel) 2017 Nov 16;4(4). Epub 2017 Nov 16.
    Executive Chair of WCBME 2017, President, BIT Congress Inc., Dalian 116025, China.
    We are delighted to present within this meeting report the abstracts of the "BIT's 1st World Congress of Biomedical Engineering 2017" which has been hold in Xi'an in China [... Read More

    Biological Properties of Low-Toxic PLGA and PLGA/PHB Fibrous Nanocomposite Scaffolds for Osseous Tissue Regeneration. Evaluation of Potential Bioactivity.
    Molecules 2017 Oct 28;22(11). Epub 2017 Oct 28.
    Department of Experimental Surgery and Biomaterials Research, Wrocław Medical University, Pasteura 1, 50-367 Wrocław, Poland.
    Abstracts: The aim of the study was to evaluate the biocompatibility and bioactivity of two new prototype implants for bone tissue regeneration made from biodegradable fibrous materials. The first is a newly developed poly(l-lactide-co-glycolide), (PLGA), and the second is a blend of PLGA with synthetic poly([R,S]-3-hydroxybutyrate) (PLGA/PHB). The implant prototypes comprise PLGA or PLGA/PHB nonwoven fabrics with designed pore structures to create the best conditions for cell proliferation. Read More

    Available studies fail to provide strong evidence of increased risk of diarrhea mortality due to measles in the period 4-26 weeks after measles rash onset.
    BMC Public Health 2017 Nov 7;17(Suppl 4):783. Epub 2017 Nov 7.
    Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
    Background: Measles vaccination effectiveness studies showed dramatic decreases in all-cause mortality in excess of what would be expected from the prevention of measles disease alone. This invited speculation that measles infection may increase the risk of diarrhea morbidity and mortality subsequent to the acute phase of the disease. The aim of the present systematic review is to summarize the existing evidence in the publically available literature pertaining to the putative causal link between measles and diarrhea in the period 4-26 weeks following measles rash onset. Read More

    Water, sanitation and hygiene interventions for acute childhood diarrhea: a systematic review to provide estimates for the Lives Saved Tool.
    BMC Public Health 2017 Nov 7;17(Suppl 4):776. Epub 2017 Nov 7.
    Centre for Global Child Health, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M6S 1S6, Canada.
    Background: In the Sustainable Development Goals (SDGs) era, there is growing recognition of the responsibilities of non-health sectors in improving the health of children. Interventions to improve access to clean water, sanitation facilities, and hygiene behaviours (WASH) represent key opportunities to improve child health and well-being by preventing the spread of infectious diseases and improving nutritional status.

    Methods: We conducted a systematic review of studies evaluating the effects of WASH interventions on childhood diarrhea in children 0-5 years old. Read More

    Correction to: Abstracts : 29th European Congress of Pathology.
    Virchows Arch 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pathology, IPO - Porto, Portugal.
    In Poster Sessions, the first-author name was missing from the authorship group originally listed for Abstract PS-13-001 (page S176), entitled "Gastric carcinoma with lymphoid stroma: Analysis of microsatellite instability and Epstein-Barr virus status". The correct authorship group is shown above. Read More

    Correction to: Abstracts : 29th European Congress of Pathology.
    Virchows Arch 2017 Nov 16. Epub 2017 Nov 16.
    Department of Pathology, IPO-Porto, Portugal.
    In Poster Sessions, the first-author name was missing from the authorship group originally listed for Abstract PS-01-004 (page S52), entitled "Clinicopathological features of microinvasive breast cancer". The correct authorship group is shown above. Read More

    Effectiveness of Multifaceted Care Approach on Adverse Clinical Outcomes in Nondiabetic CKD: A Systematic Review and Meta-analysis.
    Kidney Int Rep 2017 Jul 16;2(4):617-625. Epub 2017 Feb 16.
    Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Canada.
    Introduction: The risk of major adverse events associated with chronic kidney disease (CKD) could potentially be reduced with effective medical interventions. The impact of multifaceted interventions as compared with usual care in patients with nondiabetic CKD is unclear. We performed a systematic review to analyze the impact of multifaceted interventions on reducing the risk of major adverse events in this population. Read More

    WITHDRAWN: Pharmacological cardioversion for atrial fibrillation and flutter.
    Cochrane Database Syst Rev 2017 Nov 15;11:CD003713. Epub 2017 Nov 15.
    Ward 11, Victoria Hospital, Hayfield Road, Kirkcaldy, UK, KY2 5AH.
    Background: Atrial fibrillation is the commonest cardiac dysrhythmia. It is associated with significant morbidity and mortality. There are two approaches to the management of atrial fibrillation: controlling the ventricular rate or converting to sinus rhythm in the expectation that this would abolish its adverse effects. Read More

    WITHDRAWN: Transcendental meditation for the primary prevention of cardiovascular disease.
    Cochrane Database Syst Rev 2017 Nov 15;11:CD010359. Epub 2017 Nov 15.
    RTI Health Solutions, Manchester, UK, M20 2LS.
    Background: A major determinant in cardiovascular disease (CVD) is stress. As transcendental meditation (TM) is thought to help in lowering negative stress indicators, it may be a beneficial strategy for the primary prevention of CVD.

    Objectives: To determine the effectiveness of TM for the primary prevention of CVD. Read More

    Database resources of the National Center for Biotechnology Information.
    • Authors:
    Nucleic Acids Res 2017 Nov 13. Epub 2017 Nov 13.
    The National Center for Biotechnology Information (NCBI) provides a large suite of online resources for biological information and data, including the GenBank® nucleic acid sequence database and the PubMed database of citations and abstracts for published life science journals. The Entrez system provides search and retrieval operations for most of these data from 39 distinct databases. The E-utilities serve as the programming interface for the Entrez system. Read More

    QM/MM Simulations Identify the Ring-Opening Mechanism of Creatininase.
    Biochemistry 2017 Nov 15. Epub 2017 Nov 15.
    Creatininase catalyzes the conversion of creatinine (a biosensor for kidney function) to creatine via a two-step mechanism: water-addition followed by ring-opening. Water-addition is common to other known cyclic amidohydrolases, but the precise mechanism for ring-opening is still under debate. The proton donor in this step is either His178, or a water molecule bound to one of metal ions, and the roles of His178 and Glu122 are unclear. Read More

    Differential side effects profile in patients with mCRPC treated with abiraterone or enzalutamide: a meta-analysis of randomized controlled trials.
    Oncotarget 2017 Oct 8;8(48):84572-84578. Epub 2017 Aug 8.
    Latin American Cooperative Oncology Group, Partenon, Porto Alegre, Brazil.
    Background: Abiraterone and enzalutamide are currently approved for mCRPC patients. Both drugs have distinct mechanisms of action and may have different toxicity profile. There are limited data comparing the side effects of abiraterone and enzalutamide. Read More

    Incidence and relative risk of cutaneous squamous cell carcinoma with single-agent BRAF inhibitor and dual BRAF/MEK inhibitors in cancer patients: a meta-analysis.
    Oncotarget 2017 Oct 19;8(47):83280-83291. Epub 2017 Sep 19.
    Department of Thoracic Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
    Background: BRAF inhibitor and dual BRAF/MEK inhibitors have been approved for the treatment of BRAF-mutated melanoma. Cutaneous squamous cell carcinoma (cuSCC) is an adverse event associated with these drugs. The contribution of BRAF inhibitor and dual BRAF/MEK inhibitors to cuSCC are still unknown. Read More

    Definition of "persistent vomiting" in current medical literature: A systematic review.
    Medicine (Baltimore) 2017 Nov;96(45):e8025
    aFaculty of Medicine, Al-Azhar University bDirghayu Guru Hospital and Research Center, Chabahil, Kathmandu, Nepal cAl-Essra Hospital, Amman, Jordan dPham Ngoc Thach University of Medicine eFaculty of Medicine, Cairo University, Cairo fFaculty of Medicine, King Edward Medical University, Lahore, Pakistan gFaculty of Medicine, Tanta University, Tanta hUniversity of Medicine and Pharmacy, District 5 iUniversity of California, Los Angeles, California jDepartment of Health Ministry, Kafr El-Zayat, Gharbeya, Egypt kFaculty of Medicine, University of Mentouri Constantine, Constantine, Algeria lEvidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam mDepartment of Clinical Product Development nDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
    Background And Aim: Persistent vomiting is mentioned as a symptom of a large variety of systemic disorders. It is commonly used interchangeably with chronic, recurrent, or intractable vomiting and widely used as a warning sign of severe illness in dengue infection. However, it has been poorly defined in the medical literature. Read More

    Clinical Outcome Following Total Joint Replacement and Arthrodesis for Hallux Rigidus: A Systematic Review.
    JBJS Rev 2017 Nov 14. Epub 2017 Nov 14.
    1Department of Orthopaedics, Maastricht University Medical Centre, Maastricht, the Netherlands.
    Background: Hallux rigidus is a common cause of foot pain in the elderly and has a negative impact on quality of life. Several operative treatment options are available for feet that are refractory to conservative treatment. Of these, total joint replacement and arthrodesis of the first metatarsophalangeal joint are the most commonly performed interventions. Read More

    Correction to: Abstracts : 29th European Congress of Pathology.
    Virchows Arch 2017 Nov 14. Epub 2017 Nov 14.
    IPO-Porto, Pathology, Portugal.
    In Oral Free Paper Sessions, the first-author name was missing from the authorship group originally listed for Abstract OFP-04-012 (page S14), entitled "Differentiating primary pulmonary squamous cell carcinoma from squamous cell carcinoma of the cervix metastatic to the lung: Histological and immunohistochemistry study". Read More

    Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.
    Acta Neuropathol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Neurobiology, Barrow Neurological Institute, 350 W Thomas Road, Phoenix, AZ, 85013, USA.
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit without any known mutations. RBP dysregulation is widely accepted as a contributing factor in ALS pathobiology. Read More

    Social work's scope of practice in the provision of primary mental health care: protocol for a scoping review.
    BMJ Open 2017 Nov 12;7(11):e019384. Epub 2017 Nov 12.
    Department of Family Medicine, Schulich School of Medicine and Dentistry, Western University, London, Canada.
    Introduction: Social work is a key member of interprofessional primary healthcare teams and foundational to primary healthcare reforms that aim to improve the provision of mental healthcare. Little is known, however, about social work's scope of practice within primary healthcare settings, particularly in the provision of mental healthcare. The objective of this study is to identify and describe social work's scope of practice as it relates to mental healthcare in primary healthcare settings. Read More

    Quantifying research output on poverty and non-communicable disease behavioural risk factors in low-income and lower middle-income countries: a bibliometric analysis.
    BMJ Open 2017 Nov 12;7(11):e014715. Epub 2017 Nov 12.
    Department of Undergraduate Medicine, University of Bristol, Bristol, UK.
    Objectives: Low-income and lower middle-income countries (LLMICs) bear a disproportionate burden of non-communicable diseases (NCDs). WHO has repeatedly called for more research on poverty and NCDs in these settings, but the current situation remains unquantified. We aimed to assess research output on poverty and NCD risk factors from these countries in relation to upper middle-income and high-income countries. Read More

    Contextual factors and motivations affecting rural community sanitation in low- and middle-income countries: A systematic review.
    Int J Hyg Environ Health 2017 Nov 6. Epub 2017 Nov 6.
    Charles University, Faculty of Science, Department of Social Geography and Regional Development, Albertov 6, Prague 2, 12843, Czech Republic. Electronic address:
    Background: Unsafe management of human faecal waste represents a major risk for public health, particularly in low- and middle-income countries. Efforts to improve sanitation conditions are considerably sensitive to contextual specifics of natural and social environments. This review operationalises, analyses, and synthesises evidence of how contextual factors and motivations affect different sanitation outcomes with a specific focus on community approaches to rural sanitation. Read More

    Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis.
    JAMA Intern Med 2017 Nov 13. Epub 2017 Nov 13.
    Department Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Importance: High blood pressure (BP) is the most important risk factor for death and cardiovascular disease (CVD) worldwide. The optimal cutoff for treatment of high BP is debated.

    Objective: To assess the association between BP lowering treatment and death and CVD at different BP levels. Read More

    Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer's Disease: Systematic Review and Network Metaanalysis.
    J Am Geriatr Soc 2017 Sep 29. Epub 2017 Sep 29.
    Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
    Background/objectives: To examine the comparative effectiveness and safety of cognitive enhancers for Alzheimer's disease (AD).

    Design: Systematic review and Bayesian network metaanalysis (NMA).

    Setting: MEDLINE, EMBASE, Cochrane Library, CINAHL, Ageline (inception-March 2016). Read More

    Systematic review: advice lines for patients with inflammatory bowel disease.
    Scand J Gastroenterol 2017 Nov 13:1-7. Epub 2017 Nov 13.
    f Department of Gastroenterology , Manchester Royal Infirmary/School of Nursing, University of Manchester , Manchester , UK.
    Objective: Advice lines for patients with inflammatory bowel diseases (IBD) have been introduced internationally. However, only a few publications have described the advice line service and evaluated the efficiency of it with many results presented as conference posters. A systematic synthesis of evidence is needed and the aim of this article was to systematically review the evidence of IBD advice lines. Read More

    International Barcode of Life: Focus on big biodiversity in South Africa.
    Genome 2017 Nov;60(11):875-879
    d The African Centre for DNA Barcoding (ACDB), Department of Botany and Plant Biotechnology, University of Johannesburg, APK Campus, P.O. Box 524, Auckland Park, 2006, South Africa.
    Participants in the 7th International Barcode of Life Conference (Kruger National Park, South Africa, 20-24 November 2017) share the latest findings in DNA barcoding research and its increasingly diversified applications. Here, we review prevailing trends synthesized from among 429 invited and contributed abstracts, which are collated in this open-access special issue of Genome. Hosted for the first time on the African continent, the 7th Conference places special emphasis on the evolutionary origins, biogeography, and conservation of African flora and fauna. Read More

    The utility of oral brush cytology in the early detection of oral cancer and oral potentially malignant disorders: A systematic review.
    J Oral Pathol Med 2017 Nov 12. Epub 2017 Nov 12.
    UWA Dental School, University of Western Australia, Nedlands, WA, 6009, Australia.
    Objectives: This systematic review aimed to analyze the published evidence for the use of oral brush cytology for the early detection of oral cancer and oral potentially malignant disorders (OPMDs).

    Methods: Literature was systematically searched through several databases: MEDLINE, EMBASE, PubMed, SCOPUS, Cochrane Library and Web of Science. Additional review was performed through cross checks on the bibliographies of selected articles. Read More

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