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    Workshop Abstracts.
    Per Med 2005 May;2(2):145-185
    Department of Human Genetics and Molecular Medicine, Tel-Aviv University, Faculty of Medicine,Tel-Aviv 69978, Israel. E-mail: gurwitz@
    The first and crucial step in sensory processing, the transduction of stimuli, such as odor, light and sound, into a cellular response, are all regulated by genetic pathways. The past years have provided a significant increase in our understanding of some of these pathways, due in large part to the genes found to be associated with inherited hearing loss (HL). Read More

    Longitudinal assessment of chemotherapy-induced changes in brain and cognitive functioning: A systematic review.
    Neurosci Biobehav Rev 2018 May 20. Epub 2018 May 20.
    School of Psychology, Faculty of Health Sciences, Australian Catholic University, 115 Victoria Parade, Melbourne VIC 3065, Australia. Electronic address:
    In addition to the burden of a life-threatening diagnosis, cancer patients are struggling with adverse side-effects from cancer treatment. Chemotherapy has been linked to an array of cognitive impairments and alterations in brain structure and function ("chemobrain"). In this review, we summarized the existing evidence that evaluate the changes in cognitive functioning and brain with chemotherapy, as assessed using structural and functional MRI-based techniques in a longitudinal design. Read More

    Postoperative Pain and Analgesia: Is There a Genetic Basis to the Opioid Crisis?
    Surg Technol Int 2018 Jun;32:306-314
    Department of Orthopaedic Surgery, Lenox Hill Hospital, New York, New York.
    Background: Multiple factors have been implicated in determining why certain patients have increased postoperative pain, with the potential to develop chronic pain. The purpose of this study was to: 1) identify and describe genes that affect postoperative pain perception and control; 2) address modifiable risk factors that result in epigenetic altered responses to pain; and 3) characterize differences in pain sensitivity and thresholds between opioid-naïve and opioid-dependent patients.

    Materials And Methods: Three electronic databases were used to conduct the literature search: Pubmed, EBSCO host, and SCOPUS. Read More

    Effectiveness and safety of carbohydrate counting in the management of adult patients with type 1 diabetes mellitus: a systematic review and meta-analysis.
    Arch Endocrinol Metab 2018 May 17. Epub 2018 May 17.
    Departamento de Clínica Médica, Faculdade de Medicina de Botucatu, Universidade Estadual de São Paulo, Botucatu, SP, Brasil.
    Objective: This study aimed to evaluate the effectiveness and safety of carbohydrate counting (CHOC) in the treatment of adult patients with type 1 diabetes mellitus (DM1).

    Materials And Methods: We performed a systematic review of randomized studies that compared CHOC with general dietary advice in adult patients with DM1. The primary outcomes were changes in glycated hemoglobin (HbA1c), quality of life, and episodes of severe hypoglycemia. Read More

    What do Cochrane systematic reviews say about cardiac arrest management?
    Sao Paulo Med J 2018 Mar;136(2):170-176
    Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
    Context And Objective: Cardiac arrest is associated with high morbidity and mortality and imposes a significant burden on the healthcare system. Management of cardiac arrest patients is complex and involves approaches with multiple interventions. Here, we aimed to summarize the available evidence regarding the interventions used in cardiac arrest cases. Read More

    [Primary biliary cholangitis. Part 2. State of the art, diagnosis, associated diseases, treatment and prognosis].
    Rev Gastroenterol Peru 2018 Jan-Mar;38(1):64-71
    Universidad Nacional de Colombia. Bogotá, Colombia; Hospital Universitario Nacional de Colombia. Bogotá, Colombia.
    Primary biliary cholangitis (PBC) is a chronic autoimmune cholangiopathy characterized by a selective destruction of biliary epithelial cells of small and medium caliber hepatic ducts, which mainly affects women. The main symptoms are fatigue and pruritus, however, a large proportion of patients may be asymptomatic. The diagnosis is based on AMA titers >1:40, alkaline phosphatase >1. Read More

    Cancer Dissemination, Hydrocephalus, and Survival After Cerebral Ventricular Entry During High-Grade Glioma Surgery: A Meta-Analysis.
    Neurosurgery 2018 May 22. Epub 2018 May 22.
    Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee.
    Background: The consequences of ventricular entry during resection of high-grade gliomas (HGG) are uncertain and often not detectable clinically.

    Objective: To reveal odds of tumor dissemination, hydrocephalus, and mortality in adult patients who had ventricular entry during surgical resection of HGG.

    Methods: Titles and abstracts of published journals in the NCBI/NLM PubMed and OVID EMBASE databases were searched without language restriction and systematically screened. Read More

    Health Risk Behaviour among Adolescents Living with HIV in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
    Biomed Res Int 2018 28;2018:7375831. Epub 2018 Jan 28.
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute (KEMRI), P.O. Box 230, Kilifi, Kenya.
    The burden of health risk behaviour (HRB) among adolescents living with HIV (ALWHIV) in sub-Saharan Africa (SSA) is currently unknown. A systematic search for publications on HRB among ALWHIV in SSA was conducted in PubMed, Embase, PsycINFO, and Applied Social Sciences Index and Abstracts databases. Results were summarized following PRISMA guidelines for systematic reviews and meta-analyses. Read More

    Reporting quality of randomised controlled trial abstracts on age-related macular degeneration health care: a cross-sectional quantification of the adherence to CONSORT abstract reporting recommendations.
    BMJ Open 2018 May 22;8(5):e021912. Epub 2018 May 22.
    Faculty of Health, Institute for Medical Biometry and Epidemiology, Witten/Herdecke University, 58448 Witten, Germany.
    Objective: To assess the reporting quality of randomised controlled trial (RCT) abstracts on age-related macular degeneration (AMD) healthcare, to evaluate the adherence to the Consolidated Standards of Reporting Trials (CONSORT) statement's recommendations on minimum abstract information and to identify journal characteristics associated with abstract reporting quality.

    Design: Cross-sectional evaluation of RCT abstracts on AMD healthcare.

    Methods: A PubMed search was implemented to identify RCT abstracts on AMD healthcare published in the English language between January 2004 and December 2013. Read More

    An Update on Drug-induced Oral Reactions.
    J Pharm Pharm Sci 2018 ;21(1):171-183
    Toxicology and Diseases Group, The Institute of Pharmaceutical Sciences, Tehran University of Medical Sciences, Tehran, Iran.
    Adverse drug reactions (ADRs) are one of the major culprits in the development of oral lesions, which can be misdiagnosed with underlying diseases. The goal of this study is to summarize and update the current knowledge about drug-induced oral reactions. Electronic searches were performed in Scopus, Google Scholar, Cochrane and PubMed databases, for articles published between January 2008 and August 2017. Read More

    Evidence for telehealth group-based treatment: A systematic review.
    J Telemed Telecare 2018 Jan 1:1357633X18775855. Epub 2018 Jan 1.
    Department of Psychiatry and Psychology, Mayo Clinic, USA.
    Background Interest in the use of telehealth interventions to increase access to healthcare services is growing. Group-based interventions have the potential to increase patient access to highly needed services. The aim of this study was to systematically review the available literature on group-based video teleconference services. Read More

    ezTag: tagging biomedical concepts via interactive learning.
    Nucleic Acids Res 2018 May 18. Epub 2018 May 18.
    National Center for Biotechnology Information (NCBI), National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
    Recently, advanced text-mining techniques have been shown to speed up manual data curation by providing human annotators with automated pre-annotations generated by rules or machine learning models. Due to the limited training data available, however, current annotation systems primarily focus only on common concept types such as genes or diseases. To support annotating a wide variety of biological concepts with or without pre-existing training data, we developed ezTag, a web-based annotation tool that allows curators to perform annotation and provide training data with humans in the loop. Read More

    Criteria for assessing the quality of mHealth apps: a systematic review.
    J Am Med Inform Assoc 2018 May 16. Epub 2018 May 16.
    Research and Development Department, DMD Santé, Paris, France.
    Objective: Review the existing studies including an assessment tool/method to assess the quality of mHealth apps; extract their criteria; and provide a classification of the collected criteria.

    Methods: In accordance with the PRISMA statement, a literature search was conducted in MEDLINE, EMBase, ISI and Scopus for English language citations published from January 1, 2008 to December 22, 2016 for studies including tools or methods for quality assessment of mHealth apps. Two researchers screened the titles and abstracts of all retrieved citations against the inclusion and exclusion criteria. Read More

    Diagnosis of bloodstream infections from positive blood cultures and directly from blood samples: recent developments in molecular approaches.
    Clin Microbiol Infect 2018 May 19. Epub 2018 May 19.
    University of Groningen, University Medical Center Groningen, Department of Medical Microbiology, Groningen, The Netherlands. Electronic address:
    Background: Bloodstream infections are a major cause of death with increasing incidence and severity. Blood cultures are still the gold standard for microbiological diagnosis, but are rather slow. Molecular methods can be used as add-on complementary assays. Read More

    Outcome of polycystic kidney disease patients on peritoneal dialysis: Systematic review of literature and meta-analysis.
    PLoS One 2018 22;13(5):e0196769. Epub 2018 May 22.
    Division of Nephrology, University Hospital of Reims, Reims, France.
    Background: Polycystic kidney disease (PKD) is the most frequent hereditary cause of chronic kidney disease. Peritoneal dialysis (PD) is often avoided for patients with PKD because of the suspected risk of mechanical and infectious complications. Only a few studies have analyzed the outcome of PKD patients on PD with sometimes conflicting results. Read More

    Blue-light filtering intraocular lenses (IOLs) for protecting macular health.
    Cochrane Database Syst Rev 2018 May 22;5:CD011977. Epub 2018 May 22.
    Department of Optometry and Vision Sciences, The University of Melbourne, Level 4, Alice Hoy Building, Parkville, Victoria, Australia, 3010.
    Background: An intraocular lens (IOL) is a synthetic lens that is surgically implanted within the eye following removal of the crystalline lens, during cataract surgery. While all modern IOLs attenuate the transmission of ultra-violet (UV) light, some IOLs, called blue-blocking or blue-light filtering IOLs, also reduce short-wavelength visible light transmission. The rationale for blue-light filtering IOLs derives primarily from cell culture and animal studies, which suggest that short-wavelength visible light can induce retinal photoxicity. Read More

    Strategies to Increase Filipino American Participation in Cardiovascular Health Promotion: A Systematic Review.
    Prev Chronic Dis 2018 May 17;15:E59. Epub 2018 May 17.
    University of Hawai'i at Mānoa, Office of Public Health Studies, Honolulu, Hawai'i.
    Introduction: Cultural tailoring of interventions can be effective in reducing health disparities by attracting underserved populations to health promotion programs and improving their outcomes. The purpose of this systematic review was to assess what is known about increasing access to and participation in cardiovascular disease (CVD) prevention and control programs among Filipino Americans.

    Methods: PubMed MEDLINE, CINAHL, and Sociologic Abstracts were searched for peer-reviewed studies and dissertations conducted in the United States from 2004 through 2016. Read More

    Prophylactic Central Compartment Neck Dissection in Papillary Thyroid Cancer and Effect on Locoregional Recurrence.
    Ann Surg Oncol 2018 May 21. Epub 2018 May 21.
    Division of Surgical Oncology and Endocrine Surgery, Vanderbilt University, Nashville, TN, USA.
    Background: Prophylactic central compartment neck dissection (pCCND) in addition to total thyroidectomy (TT) includes removal of central compartment lymph nodes in the absence of clinical involvement on preoperative and intraoperative evaluation. The data regarding the influence of pCCND on oncologic outcomes and surgical complication rates is mixed and, therefore, is the focus of this analysis.

    Methods: A systematic review of the literature on total thyroidectomy with prophylactic central compartment neck dissection (TT + pCCND) from January 1990 to October 2017 identified 221 abstracts of which 17 met inclusion criteria and were reviewed (1 randomized-control trial, 13 retrospective cohort studies, and 3 meta-analyses). Read More

    Diagnostic accuracy of point-of-care natriuretic peptide testing for chronic heart failure in ambulatory care: systematic review and meta-analysis.
    BMJ 2018 May 21;361:k1450. Epub 2018 May 21.
    Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford OX2 6GG, UK
    Objective: To assess the diagnostic accuracy of point-of-care natriuretic peptide tests in patients with chronic heart failure, with a focus on the ambulatory care setting.

    Design: Systematic review and meta-analysis.

    Data Sources: Ovid Medline, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects, Embase, Health Technology Assessment Database, Science Citation Index, and Conference Proceedings Citation Index until 31 March 2017. Read More

    The impact of OPRM1's genetic polymorphisms on methadone maintenance treatment in opioid addicts: a systematic review.
    Pharmacogenomics 2018 Jun 22;19(8):741-747. Epub 2018 May 22.
    Psychiatry Department, Razi Hospital, Manouba,  Tunisia.
    Aim: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. Read More

    Stroke Prevalence in Children With Sickle Cell Disease in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.
    Glob Pediatr Health 2018 14;5:2333794X18774970. Epub 2018 May 14.
    Columbia University Medical Center, New York, NY, USA.
    . The prevalence of stroke among children with sickle cell disease (SCD) in sub-Saharan Africa was systematically reviewed. . Read More

    Gallnuts: A Potential Treasure in Anticancer Drug Discovery.
    Evid Based Complement Alternat Med 2018 29;2018:4930371. Epub 2018 Mar 29.
    Luoyang Traditional Chinese Medicine Association, Luoyang, Henan, China.
    In the discovery of more potent and selective anticancer drugs, the research continually expands and explores new bioactive metabolites coming from different natural sources. Gallnuts are a group of very special natural products formed through parasitic interaction between plants and insects. Though it has been traditionally used as a source of drugs for the treatment of cancerous diseases in traditional and folk medicinal systems through centuries, the anticancer properties of gallnuts are barely systematically reviewed. Read More

    Detecting trends in academic research from a citation network using network representation learning.
    PLoS One 2018 21;13(5):e0197260. Epub 2018 May 21.
    The Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
    Several network features and information retrieval methods have been proposed to elucidate the structure of citation networks and to detect important nodes. However, it is difficult to retrieve information related to trends in an academic field and to detect cutting-edge areas from the citation network. In this paper, we propose a novel framework that detects the trend as the growth direction of a citation network using network representation learning(NRL). Read More

    Posterior lamellar reconstruction: a comprehensive review of the literature.
    Orbit 2018 May 21:1-16. Epub 2018 May 21.
    a Clinic Department of Plastic and Recostructive Surgery , Ospedale Santa Maria della Misericordia , Udine , Italy.
    The aim of the review is to describe the different techniques and materials available to reconstruct the tarsoconjunctival layer of the eyelid; to analyze their indications, advantages, and disadvantages. We searched the Cochrane, PubMed, and Ovid MEDLINE databases for English articles published between January 1990 and January 2017 using variations of the following key words: "posterior lamella," "eyelid reconstruction," "tarsoconjunctival," "flap," and "graft." Two reviewers checked the abstracts of the articles found to eliminate redundant or not relevant articles. Read More

    Targeting the B-cell receptor pathway: a review of current and future therapies for non-Hodgkin's lymphoma.
    Expert Opin Emerg Drugs 2018 May 20. Epub 2018 May 20.
    a James P. Wilmot Cancer Institute, University of Rochester Medical Center , Rochester , NY.
    Introduction: The B-cell receptor (BCR) pathway is a crucial aspect of mature lymphocytes and is maintained in B-cell neoplasms. Many small module inhibitors targeting kinases within the BCR pathway are approved, with others in development, offering alternative treatment options to standard chemoimmunotherapy. Areas Covered: This review covers both approved inhibitors and investigational inhibitors of spleen tyrosine kinase (SYK), Bruton's tyrosine kinase (BTK), and phosphoinositide-3-kinase (PI3K) in the treatment of B-cell lymphomas. Read More

    Efficacy and safety of levetiracetam for migraine prophylaxis: A systematic review.
    J Clin Pharm Ther 2018 May 20. Epub 2018 May 20.
    Pharmacy Service, Durham VA Health Care System, Durham, NC, USA.
    What Is Known And Objective: Migraine is a common and costly neurological disorder that affects approximately 1 of every 7 people annually. Pharmacological therapy for prevention of migraine is warranted when patients experience at least 6 headache days, 4 headache days with at least some impairment or 3 headache days with severe impairment or requiring bed rest in a month. Levetiracetam is an antiepileptic drug that has the potential to be beneficial for migraine prophylaxis. Read More

    Gender differences in the relationship between built environment and non-communicable diseases: A systematic review.
    J Public Health Res 2018 Feb 20;7(1):1239. Epub 2018 Apr 20.
    Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, Kerala, India.
    Non-communicable diseases are on the rise globally. Risk factors of non-communicable diseases continue to be a growing concern in both developed and developing countries. With significant rise in population and establishment of buildings, rapid changes have taken place in the built environment. Read More

    Adolescent self-consent for vaccinations: protocol for a mixed methods systematic review.
    BMJ Open 2018 May 20;8(5):e021335. Epub 2018 May 20.
    Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
    Introduction: The recent global expansion of routine adolescent vaccination programmes has the potential to protect young people against the acquisition of infectious disease and improve their health. Although in many countries the legal framework supports young people to provide consent for medical interventions if they are considered competent, written parental consent can act as a barrier to uptake as it is frequently a condition of adolescent vaccination programmes. The aim of this systematic review protocol is to document the methods which will be used to identify, appraise and synthesise the available qualitative and quantitative evidence to address: (1) whether implementation of adolescent self-consent procedures can increase vaccination uptake and (2) the barriers and facilitators to implementation of adolescent self-consent procedures. Read More

    Induced endometrial trauma (endometrial scratch) in the mid-luteal menstrual cycle phase preceding first cycle IVF/ICSI versus usual IVF/ICSI therapy: study protocol for a randomised controlled trial.
    BMJ Open 2018 May 20;8(5):e020755. Epub 2018 May 20.
    Fertility Unit - Jessop Wing, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.
    Introduction: Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing in vitro fertilisation (IVF), with or without intracytoplasmic sperm injection (ICSI). However, the procedure has not yet been fully explored in women having IVF/ICSI for the first time. This study aims to examine the effect of performing an ES in the mid-luteal phase prior to a first-time IVF/ICSI cycle on the chances of achieving a clinical pregnancy and live birth. Read More

    Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis.
    Lancet Oncol 2018 May 16. Epub 2018 May 16.
    Division of Medical Oncology for Melanoma & Sarcoma, European Institute of Oncology, Milan, Italy.
    Background: Despite the acknowledged sex-related dimorphism in immune system response, little is known about the effect of patients' sex on the efficacy of immune checkpoint inhibitors as cancer treatments. We did a systematic review and meta-analysis to assess the heterogeneity of immune checkpoint inhibitor efficacy between men and women.

    Methods: We systematically searched PubMed, MEDLINE, Embase, and Scopus, from database inception to Nov 30, 2017, for randomised controlled trials of immune checkpoint inhibitors (inhibitors of PD-1, CTLA-4, or both) that had available hazard ratios (HRs) for death according to patients' sex. Read More

    What do we know about sibling attended birth? An integrative literature review.
    Midwifery 2018 May 8;63:24-32. Epub 2018 May 8.
    Otago Polytechnic, School of Midwifery, Forth Street, Dunedin, Private Bag 1910, New Zealand 9054. Electronic address:
    Objective: to consolidate existing research in the field of sibling attended birth (SAB) into a body of knowledge to inform decision-making processes and guide midwifery practice throughout the sibling attended birth experience.

    Design: An integrative literature review.

    Data Sources: CINAHL Complete, Cochrane Library, PubMed, Index New Zealand, Australia/New Zealand Reference Centre, grey literature databases REVIEW METHODS: An extensive search of five electronic databases as well as 17 grey literature databases was conducted. Read More

    Clinical prediction models to support the diagnosis of asthma in primary care: a systematic review protocol.
    NPJ Prim Care Respir Med 2018 May 18;28(1):15. Epub 2018 May 18.
    Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Edinburgh, Scotland.
    Substantial over-diagnosis and under-diagnosis of asthma in adults and children has recently been reported. As asthma is mostly diagnosed in non-specialist settings, a clinical prediction model (CPM) to aid the diagnosis of asthma in primary care may help improve diagnostic accuracy. We aim to systematically identify, describe, compare, and synthesise existing CPMs designed to support the diagnosis of asthma in children and adults presenting with symptoms suggestive of the disease, in primary care settings or equivalent populations. Read More

    The effect of age and sex on the cervical range of motion - A systematic review and meta-analysis.
    J Biomech 2018 May 7. Epub 2018 May 7.
    Julius Wolff Institut, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Germany. Electronic address:
    Cervical-flexibility examination is routinely performed in neck-pain patients. However, diagnosis of cervical-flexibility impairment requires physiological reference values, which vary widely among the population. Although there is a general understanding that the cervical range of motion (RoM) alters with age and sex, the consolidated details of these variations remain lacking. Read More

    Duration of dual antiplatelet therapy and outcome in patients with acute coronary syndrome undergoing percutaneous revascularization: A meta-analysis of 11 randomized trials.
    Int J Cardiol 2018 Aug;264:30-38
    Division of Cardiology, Azienda Ospedaliera-Universitaria "Maggiore della Carità", Eastern Piedmont University, Novara, Italy. Electronic address:
    Background: Acute coronary syndromes (ACS) represent a context of higher thrombotic risk, where larger advantages have been achieved by the administration of dual antiplatelet therapy (DAPT). However, the indication of 1 year DAPT after coronary angioplasty for ACS has been supported by an outdated randomized trial (PCI-CURE). In addition, the initial fear of late thrombotic events emerged with first generation drug-eluting stents (DES), that suggested the need of a prolonged DAPT prescription, has been completely overcome by the recent technological evolution of DES, that have shown faster re-endothelization and lower rates of late thrombotic complications. Read More

    Policy development and challenges of global mental health: a systematic review of published studies of national-level mental health policies.
    BMC Psychiatry 2018 May 18;18(1):138. Epub 2018 May 18.
    Department of Social Medicine and Health Management, School of Public Health, Central South University, Changsha, China.
    Background: Mental health policy can be an essential and powerful tool to improve a population's mental health. However, around one third of countries do not possess a mental health policy, and there are large disparities in population coverage rates between high- and low-income countries. The goal of this study is to identify the transition and implementation challenges of mental health policies in both high-income countries (HICs) as well as middle- and low-income countries (MLICs). Read More

    A systematic review of the risk factors for clinical response to opioids for all-age patients with cancer-related pain and presentation of the paediatric STOP pain study.
    BMC Cancer 2018 May 18;18(1):568. Epub 2018 May 18.
    Department of Neuroscience, Psychology, Drug Research and Children's Health, University of Florence, Florence, Italy.
    Background: Inter-patient variability in response to opioids is well known but a comprehensive definition of its pathophysiological mechanism is still lacking and, more importantly, no studies have focused on children. The STOP Pain project aimed to evaluate the risk factors that contribute to clinical response and adverse drug reactions to opioids by means of a systematic review and a clinical investigation on paediatric oncological patients.

    Methods: We conducted a systematic literature search in EMBASE and PubMed up to the 24th of November 2016 following Cochrane Handbook and PRISMA guidelines. Read More

    A systematic review of community-based interventions to improve oral chronic disease medication regimen adherence among individuals with substance use disorder.
    Drug Alcohol Depend 2018 May 1;188:141-152. Epub 2018 May 1.
    Massachusetts College of Pharmacy and Health Sciences University, 179 Longwood Avenue, Boston, MA, 02155, USA.
    Background: Poor medication adherence has been shown to cause medical complications, death, and increased healthcare costs and may be of particular importance in patients with substance use disorder (SUD). Concerns regarding adherence in this population may influence a healthcare provider's decision to prescribe a medication requiring high adherence. Guidance defining best practices that promote adherence among individuals with SUD is lacking. Read More

    Open Versus Laparoscopic Approach for Morgagni's Hernia in Infants and Children: A Systematic Review and Meta-Analysis.
    J Laparoendosc Adv Surg Tech A 2018 May 18. Epub 2018 May 18.
    1 Division of General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, University of Toronto , Toronto, Canada .
    Introduction: The laparoscopic repair of Morgagni's hernia (MH) has been reported to be safe and feasible. However, it is still unclear whether laparoscopy is superior to open surgery in repairing MH.

    Materials And Methods: Using a defined search strategy, three investigators independently identified all comparative studies reporting data on open and laparoscopic MH repair in patients <18 years of age. Read More

    Phrase Mining of Textual Data to Analyze Extracellular Matrix Protein Patterns Across Cardiovascular Disease.
    Am J Physiol Heart Circ Physiol 2018 May 18. Epub 2018 May 18.
    Computer Science, University of Illinois at Urbana Champaign.
    Extracellular matrix (ECM) proteins have been shown to play important roles regulating multiple biological processes in an array of organ systems, including the cardiovascular system. By using a novel bioinformatics text-mining tool, we studied six categories of cardiovascular disease (CVD), namely ischemic heart disease (IHD), cardiomyopathies (CM), cerebrovascular accident (CVA), congenital heart disease (CHD), arrhythmias (ARR), and valve disease (VD), anticipating novel ECM protein-disease and protein-protein relationships hidden within vast quantities of textual data. We conducted a phrase-mining analysis, delineating the relationships of 709 ECM proteins with the six groups of CVDs reported in 1,099,254 abstracts. Read More

    [Meta-analysis of gastric stump cancer after gastrectomy for gastric cancer].
    Zhonghua Wei Chang Wai Ke Za Zhi 2018 May;21(5):569-577
    Department of Gastrointestinal Surgery, Peking University People's Hospital, Beijing 100044, China.
    Objective: To study the clinicopathological features and prognosis of gastric stump cancer (GSC) following subtotal gastrectomy for gastric cancer, to compare the clinicopathologic differences between narrow GSC and generalized GSC, and to compare the prognosis between GSC and primary proximal gastric cancer (PPGC) after radical resection.

    Methods: Literatures of GSC-associated clinical study were searched by computer from the Cochrane Library, Medline, PubMed, CNKI, Wanfang and VIP databases, and the retrieval period was from the establishment of database to December 31, 2017.

    Inclusion Criteria: (1) GSC was defined as a carcinoma arising in the gastric remnant after radical gastrectomy for gastric cancer, and confirmed by the pathological or histological examination, the elapsed time from the initial operation was not considered in the definition. Read More

    Protocol for the validation of sensitivity and specificity of the Cow's Milk-related Symptom Score (CoMiSS) against open food challenge in a single-blinded, prospective, multicentre trial in infants.
    BMJ Open 2018 May 17;8(5):e019968. Epub 2018 May 17.
    Children's Hospital Zhejiang, University School of Medicine, Hangzhou, China.
    Introduction: The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis. Read More

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