51,779 results match your criteria Abstracts Published in Conference Program [Journal]


Helicobacter pylori eradication for the prevention of gastric neoplasia.

Cochrane Database Syst Rev 2020 Jul 6;7:CD005583. Epub 2020 Jul 6.

Department of Medicine, Division of Gastroenterology, McMaster University, Hamilton, Canada.

Background: Gastric cancer is the third most common cause of cancer death worldwide. Individuals infected with Helicobacter pylori have a higher likelihood of developing gastric cancer than individuals who are not infected. Eradication of H. Read More

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http://dx.doi.org/10.1002/14651858.CD005583.pub3DOI Listing

A systematic review and evidence synthesis of non-medical triage, self-referral and direct access services for patients with musculoskeletal pain.

PLoS One 2020 6;15(7):e0235364. Epub 2020 Jul 6.

Arthritis Research UK Primary Care Centre, School of Primary, Community & Social Care, Keele University, Keele, United Kingdom.

Introduction: The demand for musculoskeletal (MSK) care is rising, and is a growing challenge for general practice. Direct access to physiotherapy and other healthcare services may offer appropriate care for MSK pain patients but there is uncertainty regarding the effectiveness or efficiency of this approach in practice. This study aimed to review the evidence regarding characteristics, outcomes, barriers and facilitators of MSK triage and direct access services. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235364PLOS

A Systematic Review of the Effectiveness of Behavioral Treatments for Pica in Youths.

Clin Psychol Psychother 2020 Jul 6. Epub 2020 Jul 6.

Department of Psychology, University of Guelph, Guelph, Canada.

Pica is the persistent consumption of non-nutritive, non-food substances, and is associated with adverse health complications. However, there is limited research on interventions for pica in youth. The objective of this study is to systematically review the empirical evidence for the effectiveness of behavioral interventions for pica in children and adolescents and to generate treatment recommendations. Read More

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http://dx.doi.org/10.1002/cpp.2491DOI Listing

Behavioural activation therapy for depression in adults.

Cochrane Database Syst Rev 2020 Jul 6;7:CD013305. Epub 2020 Jul 6.

Cochrane Common Mental Disorders, University of York, York, UK.

Background: Behavioural activation is a brief psychotherapeutic approach that seeks to change the way a person interacts with their environment. Behavioural activation is increasingly receiving attention as a potentially cost-effective intervention for depression, which may require less resources and may be easier to deliver and implement than other types of psychotherapy.

Objectives: To examine the effects of behavioural activation compared with other psychological therapies for depression in adults. Read More

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http://dx.doi.org/10.1002/14651858.CD013305.pub2DOI Listing

A decade of next-generation sequencing in genodermatoses: the impact on gene discovery and clinical diagnostics.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

St John's Institute of Dermatology, School of Basic and Medical Biosciences, King's College London, London, UK.

Background: Discovering the genetic basis of inherited skin diseases is fundamental to improving diagnostic accuracy and genetic counselling. In the 1990s and 2000s, genetic linkage and candidate gene approaches led to the molecular characterisation of several dozen genodermatoses, but over the past decade the advent of next-generation sequencing (NGS) technologies has accelerated diagnostic discovery and precision.

Objectives: This review examines the application of NGS technologies from 2009 to 2019 that have (a) led to the initial discovery of gene mutations in known or new genodermatoses and (b) identified more than one contributing pathogenic gene involvement in individuals with complex Mendelian skin disorder phenotypes. Read More

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http://dx.doi.org/10.1111/bjd.19384DOI Listing

Reporting of Research by Matched Otolaryngology Residency Applicants.

Ann Otol Rhinol Laryngol 2020 Jul 4:3489420938821. Epub 2020 Jul 4.

Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Rutgers-New Jersey Medical School, Newark, NJ, USA.

Objectives: Matching to an otolaryngology residency program is a competitive process for medical students, and research performed by students is considered as a factor for granting interviews by program directors. Because abstracts, presentations and publications are all reported in combination by the National Resident Matching Program's "Charting Outcomes in the Match" (ChOM) and may be weighted differently by PDs, we specifically investigated the number of publications by past applicants accepted to top otolaryngology residency programs.

Methods: The top 25 otolaryngology residency programs were identified using Doximity, sorting by reputation. Read More

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http://dx.doi.org/10.1177/0003489420938821DOI Listing

Efficacy and safety of iGlarLixi versus IDegLira in adults with type 2 diabetes inadequately controlled by glucagon-like peptide-1 receptor agonists (GLP-1RAs): a systematic literature review and indirect treatment comparison.

Diabetes Obes Metab 2020 Jul 6. Epub 2020 Jul 6.

Doctor Evidence, Santa Monica, CA, USA.

Aims: To estimate the relative treatment effect between the fixed ratio combinations (FRCs) iGlarLixi and IDegLira (glucagon-like peptide 1 receptor agonist [GLP-1RA] with basal insulin) in people with type 2 diabetes (T2D) inadequately controlled on a GLP-1RA.

Materials And Methods: A systematic literature review of randomized controlled trials followed by an indirect treatment comparison (ITC) was performed to compare the efficacy and safety of the available FRCs. Main outcomes were HbA1c change and target achievement (<6. Read More

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http://dx.doi.org/10.1111/dom.14136DOI Listing

Voting, health and interventions in healthcare settings: a scoping review.

Public Health Rev 2020 1;41:16. Epub 2020 Jul 1.

Department of Family and Community Medicine, St. Michael's Hospital, Toronto, ON Canada.

Background: In democracies, voting is an important action through which citizens engage in the political process. Although elections are only one aspect of political engagement, voting sends a signal of support or dissent for policies that ultimately shape the social determinants of health. Social determinants subsequently influence who votes and who does not. Read More

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http://dx.doi.org/10.1186/s40985-020-00133-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329475PMC

A systematic review of cognitive function in patients with glioblastoma undergoing surgery.

Neurooncol Pract 2020 Mar 23;7(2):131-142. Epub 2019 Apr 23.

University of Cambridge, Division of Clinical Neurosciences, UK.

Background: Patients with glioblastoma (GB) are more likely to suffer cognitive deficits with poor quality of life as compared with lower-grade glioma patient groups, for whom cognition research is plentiful. The objective of this systematic review is to evaluate the cognitive function of patients with GB before and after surgery.

Methods: This review was prospectively registered with PROSPERO. Read More

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http://dx.doi.org/10.1093/nop/npz018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318858PMC

Developing a standard set of patient-centred outcomes for adult oral health - an international, cross-disciplinary consensus.

Int Dent J 2020 Jul 5. Epub 2020 Jul 5.

ICHOM Adult Oral Health Working Group, Boston, MA, USA.

Objective: To develop a minimum Adult Oral Health Standard Set (AOHSS) for use in clinical practice, research, advocacy and population health.

Materials And Methods: An international oral health working group (OHWG) was established, of patient advocates, researchers, clinicians and public health experts to develop an AOHSS. PubMed was searched for oral health clinical and patient-reported measures and case-mix variables related to caries and periodontal disease. Read More

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http://dx.doi.org/10.1111/idj.12604DOI Listing

Prevalence of Anti-JC Virus Antibody Seropositivity in Patients with Multiple Sclerosis: A Systematic Review and Meta-Analysis.

Intervirology 2020 07 3:1-5. Epub 2020 Jul 3.

Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran,

Background: The John Cunningham virus (JCV) is the causative agent of progressive multifocal leukoencephalopathy. Anti-JCV antibody seropositivity is an important consideration in patients with multiple sclerosis (MS). The reported prevalence of JCV in MS patients has been conflicting. Read More

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http://dx.doi.org/10.1159/000507367DOI Listing

Individual predictors of the susceptibility for motion-related sickness: A systematic review.

J Vestib Res 2020 Jun 27. Epub 2020 Jun 27.

German Aerospace Center - Institute for Aerospace Medicine, Germany.

Background: Individuals seem to be differently susceptible to motion-related sickness (motion sickness, visually induced sickness etc.). Investigations of the reasons for these different susceptibilities have revealed many potential factors that could predict individual susceptibility to motion-related sickness. Read More

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http://dx.doi.org/10.3233/VES-200702DOI Listing

Analysis and proceeding to full publication of abstracts presented at the Pancreas Club annual meeting.

Pancreatology 2020 Jun 17. Epub 2020 Jun 17.

Unit of General and Pancreatic Surgery, Department of Surgery and Oncology, University of Verona Hospital Trust, Italy.

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http://dx.doi.org/10.1016/j.pan.2020.05.005DOI Listing

Exercise for people with a fragility fracture of the pelvis or lower limb: a systematic review of interventions evaluated in clinical trials and reporting quality.

BMC Musculoskelet Disord 2020 Jul 4;21(1):435. Epub 2020 Jul 4.

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.

Background: To aid design of exercise trials for people with pelvic and lower limb fragility fractures a systematic review was conducted to identify what types of exercise interventions and mobility outcomes have been assessed, investigate intervention reporting quality, and evaluate risk of bias in published trials.

Methods: Systematic searches of electronic databases (CENTRAL, MEDLINE, EMBASE, PEDro) 1996-2019 were conducted to identify randomised controlled trials of exercise for pelvic or lower limb fragility fractures. Two reviewers independently screened titles and abstracts. Read More

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http://dx.doi.org/10.1186/s12891-020-03361-8DOI Listing

The effect of intralipid on pregnancy outcomes in women with previous implantation failure in in vitro fertilization/intracytoplasmic sperm injection cycles: A systematic review and meta-analysis.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 26;252:187-192. Epub 2020 Jun 26.

Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China. Electronic address:

Several recent studies have investigated the relationship between intravenous intralipid and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes in women with previous implantation failure. We conducted a systematic review and meta-analysis to evaluate the effects of intravenous intralipid on pregnancy outcomes in women with previous implantation failure. Ovid MEDLINE, the Cochrane Library, Embase and ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.06.057DOI Listing

Cinacalcet and primary hyperparathyroidism: systematic review and meta regression.

Endocr Connect 2020 Jul 1. Epub 2020 Jul 1.

C Khoo, Medicine, NUS Yong Loo Lin School of Medicine, Singapore, 117597, Singapore.

Purpose: Primary hyperparathyroidism (PHPT) is common condition, affecting people of all ages and is mainly treated with parathyroidectomy. Cinacalcet has been widely used in secondary or tertiary hyperparathyroidism, but the use of cinacalcet in PHPT is less clear.

Methods: Searches were conducted in Medline and Embase for cinacalcet use in PHPT from induction to 10th April 2020. Read More

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http://dx.doi.org/10.1530/EC-20-0221DOI Listing

Fibrin and Thrombin Sealants in Vascular and Cardiac Surgery: A Systematic Review and Meta-analysis.

Eur J Vasc Endovasc Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, Hamilton, ON, Canada; Division of Cardiac Surgery, McMaster University, Hamilton, ON, Canada. Electronic address:

Objective: In vascular and cardiac surgery, the ability to maintain haemostasis and seal haemorrhagic tissues is key. Fibrin and thrombin based sealants were introduced as a means to prevent or halt bleeding during surgery. Whether fibrin and thrombin sealants affect surgical outcomes is poorly established. Read More

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http://dx.doi.org/10.1016/j.ejvs.2020.05.016DOI Listing

Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis.

J Proteomics 2020 Jun 30;226:103888. Epub 2020 Jun 30.

iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:

Prostate cancer (PCa) treatment remains challenging, especially in advanced stages, where the lack of sensitivity and specificity of available biomarkers makes it difficult to establish an accurate prognosis. Therefore, it is imperative to study PCa biology to identify key molecules that can improve PCa management. In this study, eight prostate tumor tissues and paired normal tissues were analyzed using two approaches-Fourier-transform infrared (FT-IR) spectroscopy for spectroscopic profiling of biomolecules and antibody microarray for signaling proteins-with the main goal of identifying metabolic and proteomic changes that enable the distinction between normal and tumor conditions. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103888DOI Listing

External Validation Demonstrated The Ottawa SAH Prediction Models Can Identify pSAH Using Health Administrative Data.

J Clin Epidemiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine (Clinical Epidemiology), uOttawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; ICES-uOttawa, Administrative Services, 1053 Carling Ave Building, 1st Floor, Ottawa, ON K1Y 4E9.

Objective: To externally validate 3 pSAH identification models.

Study Design And Setting: We evaluated 3 models that identify pSAH using recursive partitioning (A), logistic regression (B), and a prevalence adjusted logistic regression(C), respectively. Blinded chart review and/or linkage to existing registries determined pSAH status. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.024DOI Listing

A Systematic Review and Meta-Analysis of Biceps Tenodesis Fixation Strengths: Fixation Type and Location Are Biomechanically Equivalent.

Arthroscopy 2020 Jun 30. Epub 2020 Jun 30.

Steadman Philippon Research Institute, Vail, CO; The Steadman Clinic, Vail, CO. Electronic address:

Purpose: The purpose of this meta-analysis and systematic review was to critically evaluate the biomechanical outcomes of different fixation constructs for a variety of biceps tenodesis techniques in cadaveric models based on both type of fixation as well as location.

Methods: A PROSPERO registered systematic review (CCRD42018109243) was conducted of the current literature with the terms "long head of biceps" AND "tenodesis" AND "biomechanics" and numerous variations thereof in PubMed, EMBASE, and Cochrane yielding 1460 abstracts. After screening by eligibility criteria, 18 full-text articles were included. Read More

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http://dx.doi.org/10.1016/j.arthro.2020.05.055DOI Listing

A Systematic Literature Review of Residual Symptoms and Unmet Need in Patients with Rheumatoid Arthritis.

Arthritis Care Res (Hoboken) 2020 Jul 3. Epub 2020 Jul 3.

Botnar Research Centre, University of Oxford, Oxford, OX3 7LD, UK.

Objective: To evaluate the nature and burden of residual disease in rheumatoid arthritis (RA) in patients who meet treatment targets. Secondly, for those who did not meet targets, evaluate how much is due to patient symptoms.

Methods: Prospective and retrospective studies were searched in MEDLINE, Embase, and Cochrane Library in the English language from January 1, 2008, to April 18, 2018; conference abstracts (from January 2016 to April 2018) and reference lists of relevant studies were also screened. Read More

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http://dx.doi.org/10.1002/acr.24369DOI Listing

Techniques for preventing hypotension during spinal anaesthesia for caesarean section.

Cochrane Database Syst Rev 2020 Jul 1;7:CD002251. Epub 2020 Jul 1.

Department of Women's Anaesthesia, Women's and Children's Hospital, Adelaide, Australia.

Background: Maternal hypotension is the most frequent complication of spinal anaesthesia for caesarean section. It can be associated with nausea or vomiting and may pose serious risks to the mother (unconsciousness, pulmonary aspiration) and baby (hypoxia, acidosis, neurological injury).

Objectives: To assess the effects of prophylactic interventions for hypotension following spinal anaesthesia for caesarean section. Read More

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http://dx.doi.org/10.1002/14651858.CD002251.pub4DOI Listing

Efficacy of Botulinum Toxin in Treating Lateral Epicondylitis, Does Injection Location Matter? A Systematic Review.

Am J Phys Med Rehabil 2020 Jul 1. Epub 2020 Jul 1.

H. Ben Taub Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.

Objective: Clinical trials assessing the efficacy of botulinum toxin in treating recalcitrant lateral epicondylitis have demonstrated varied results and differed greatly in methodology. The objective of this systematic review is to demonstrate injection location as a significant contributor to outcome heterogeneity.

Design: Two reviewers independently conducted a systematic review using Scopus, Embase, and Pubmed for randomized controlled trials assessing botulinum toxin in the treatment of lateral epicondylitis. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001511DOI Listing

End-of-life care in schizophrenia: a systematic review.

Int Psychogeriatr 2020 Jun 19:1-19. Epub 2020 Jun 19.

Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.

Objective: Schizophrenia is a severe and persistent mental illness with profound effects on patients, families, and communities. It causes immense suffering on personal, emotional, and socioeconomic levels. Individuals with schizophrenia have poorer health outcomes and die 10-20 years younger than the general population. Read More

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http://dx.doi.org/10.1017/S1041610220000915DOI Listing

Diode laser as an adjunct to nonsurgical chronic periodontitis therapy: a review.

J Biol Regul Homeost Agents 2020 May-Jun;34(3 Suppl. 1):45-54

University of Rome "Tor Vergata"-Department of Clinical Science and Translational Medicine, Rome, Italy.

The aim of this review was to investigate the additional effects of diode laser irradiation in combination with nonsurgical periodontal therapy. An electronic search of publications was established from three electronic databases: Cochrane, PubMed and Web of Science. The search strategy used a combination of controlled vocabulary and free-text words. Read More

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Spin in the abstracts of randomized controlled trials in periodontology and oral implantology: A cross-sectional analysis.

J Clin Periodontol 2020 Jul 2. Epub 2020 Jul 2.

Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

Objectives: To investigate the presence and characteristics of spin (a distorted interpretation to make research findings seem favorable) in abstracts of randomized controlled trials (RCTs) in periodontology and oral implantology, and to explore its associated factors and influence on the subsequent literature.

Materials And Methods: PubMed was searched to identify recent RCTs in periodontology and oral implantology, whose primary outcome was non-significant. Spin in abstracts was assessed and categorized according to pre-determined spin strategies. Read More

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http://dx.doi.org/10.1111/jcpe.13340DOI Listing

Measurement properties of preference-based measures for economic evaluation in COPD: a systematic review.

Qual Life Res 2020 Jul 2. Epub 2020 Jul 2.

School of Rehabilitation Science, McMaster University, 1400 Main St. W., Hamilton, ON, L8S 1C7, Canada.

Purpose: Preference-based measures can provide measurements of health-related quality of life and be utilized for cost-effectiveness analyses of interventions in individuals with chronic obstructive pulmonary disease (COPD). The purpose of this study is to evaluate whether generic preference-based measures are reliable, valid, and responsive in COPD.

Methods: A systematic review was performed using the Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines. Read More

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http://dx.doi.org/10.1007/s11136-020-02569-4DOI Listing

Effect of precooling on pain during local anesthesia administration in children: a systematic review.

J Dent Anesth Pain Med 2020 Jun 24;20(3):119-127. Epub 2020 Jun 24.

Department of Pedodontics & Preventive Dentistry, Malla Reddy Dental College for Women, Hyderabad, Telangana, India.

This study was conducted to determine how precooling reduces the subjective reported pain and objective pain and to evaluate the effectiveness of precooling the injection site before administration of local anesthesia in children. Electronic databases (PubMed, Ovid SP, Cochrane Central Register of Controlled Trials) were searched for publications from 1980 to 2020. Studies were screened for titles and abstracts, followed by full-text evaluation of included reports. Read More

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http://dx.doi.org/10.17245/jdapm.2020.20.3.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7321740PMC

Prior surgical uterine evacuation of pregnancy and infertility: protocol for systematic review and meta-analysis.

BMJ Open 2020 Jul 2;10(7):e034837. Epub 2020 Jul 2.

National Research Institute for Family Planning, Beijing, China

Introduction: Prior surgical uterine evacuation is associated with an increased risk of infertility. However, findings are inconsistent, highlighting the need for a clear consensus on the effect of prior surgical uterine evacuation on the risk of infertility. Therefore, the aim of this systematic review and meta-analysis is to summarise the available evidence examining the association between prior surgical uterine evacuation and the risk of infertility. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034837DOI Listing

Scoping review protocol on maternal, newborn and child health research in Ethiopia.

BMJ Open 2020 Jul 2;10(7):e034307. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, Saint Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.

Introduction: There has been a tremendous reduction in maternal and child mortality in the last decade. However, a significant number of deaths still occur disproportionately in low-income country settings. Ethiopia is the second-most populous nation in sub-Saharan Africa with a high maternal mortality rate of 412 deaths per 100 000 live births and an under-five mortality rate of 55 per 1000 live births. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034307DOI Listing

Clinical Applications of Interleukin-37: A Key Player in the Immunopathogenesis of Immune Disorders.

Iran J Allergy Asthma Immunol 2020 Jun 23;19(3):209-228. Epub 2020 Jun 23.

Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran AND Cancer Gene Therapy Research Center (CGRC), Zanjan University of Medical Sciences, Zanjan, Iran.

Recently, the era of medicine has been encountered with the exponential growth of special seroimmunobiomarkers in clinical trials. Lately, Interleukin-37 (IL-37) has attracted a wide range of basic medical scientists' attention due to its controversial functions in physiologic or pathologic microenvironments. In this research, an updated overview of immunobiological functions and clinical applications of IL-37 in a wide range of diseases, are discussed in order to highlight the role of recent laboratory-based results of IL-37. Read More

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http://dx.doi.org/10.18502/ijaai.v19i3.3450DOI Listing

Association of Checklist Use in Endotracheal Intubation With Clinically Important Outcomes: A Systematic Review and Meta-analysis.

JAMA Netw Open 2020 Jul 1;3(7):e209278. Epub 2020 Jul 1.

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis.

Importance: Endotracheal intubation of critically ill patients is a high-risk procedure. Checklists have been advocated to improve outcomes.

Objective: To assess whether the available evidence supports an association of use of airway checklists with improved clinical outcomes in patients undergoing endotracheal intubation. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9278DOI Listing

Spanish Language Abstracts.

Authors:

PM R 2020 Jul;12(7):E1-E12

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http://dx.doi.org/10.1002/pmrj.12441DOI Listing

Positionality of Community Health Workers on Health Intervention Research Teams: A Scoping Review.

Front Public Health 2020 16;8:208. Epub 2020 Jun 16.

Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, United States.

Community health workers (CHWs) are increasingly involved as members of health intervention research teams. Given that CHWs are engaged in a variety of research roles, there is a need for better understanding of the ways in which CHWs are incorporated in research and the potential benefits. This scoping review synthesizes evidence regarding the kinds of health research studies involving CHWs, CHWs' roles in implementing health intervention research, their positionality on research teams, and how their involvement benefits health intervention research. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308474PMC

Mapping adolescent sexual and reproductive health research in sub-Saharan Africa: protocol for a scoping review.

BMJ Open 2020 Jul 1;10(7):e035335. Epub 2020 Jul 1.

Population Dynamics and Sexual and Reproductive Health and Rights, African Population and Health Research Center, Nairobi, Kenya.

Introduction: Previous studies have attempted to review the vast body of evidence on adolescent sexual and reproductive health (ASRH), but none has focused on a complete mapping and synthesis of the body of inquiry and evidence on ASRH in sub-Saharan Africa (SSA). Such a comprehensive scoping is needed, however, to offer direction to policy, programming and future research. We aim to undertake a scoping review of studies on ASRH in SSA to capture the landscape of extant research and findings and identify gaps for future research. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-035335DOI Listing

Evaluating assessment tools of the quality of clinical ethics consultations: a systematic scoping review from 1992 to 2019.

BMC Med Ethics 2020 Jul 1;21(1):51. Epub 2020 Jul 1.

Division of Supportive and Palliative Care, National Cancer Centre Singapore, Level 4, 11 Hospital Drive, Singapore, 169610, Singapore.

Background: Amidst expanding roles in education and policy making, questions have been raised about the ability of Clinical Ethics Committees (CEC) s to carry out effective ethics consultations (CECons). However recent reviews of CECs suggest that there is no uniformity to CECons and no effective means of assessing the quality of CECons. To address this gap a systematic scoping review of prevailing tools used to assess CECons was performed to foreground and guide the design of a tool to evaluate the quality of CECons. Read More

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http://dx.doi.org/10.1186/s12910-020-00492-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7329412PMC

AAV vectors: Are they safe?

Authors:
Arun Srivastava

Hum Gene Ther 2020 Jul 1. Epub 2020 Jul 1.

University Of Florida College of Medicine, Division of Cellular & Molecular Therapy, Departments of Pediatrics and Molecular Genetics & Microbiology, PO Box 100196, 1600 SW Archer Road, RG 183-A, Gainesville, Florida, United States, 32610;

letter to editors do not require abstracts. Read More

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http://dx.doi.org/10.1089/hum.2020.187DOI Listing

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis.

Nutrients 2020 Jun 29;12(7). Epub 2020 Jun 29.

Department of Microbiology, Faculty of Pharmacy, University of Granada, Campus of Cartuja, 18071 Granada, Spain.

Obesity is a growing health threat worldwide. Administration of probiotics in obesity has also parallelly increased but without any protocolization. We conducted a systematic review exploring the administration pattern of probiotic strains and effective doses for obesity-related disorders according to their capacity of positively modulating key biomarkers and microbiota dysbiosis. Read More

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http://dx.doi.org/10.3390/nu12071921DOI Listing

Gastrointestinal Malignancies and the COVID-19 Pandemic: Evidence-Based Triage to Surgery.

J Gastrointest Surg 2020 Jun 30. Epub 2020 Jun 30.

Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Background: The COVID-19 pandemic has led to widespread cancelation of electively scheduled surgeries, including for colorectal, pancreatic, and gastric cancer. The American College of Surgeons and the Society of Surgical Oncology have released guidelines for triage of these procedures. We seek to synthesize available evidence on delayed resection and oncologic outcomes, while also providing a critical assessment of the released guidelines. Read More

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http://dx.doi.org/10.1007/s11605-020-04712-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325836PMC

A systematic review of pharmacist input to metabolic syndrome screening, management and prevention.

Int J Clin Pharm 2020 Jun 30. Epub 2020 Jun 30.

School of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, AB10 7AQ, Scotland, UK.

Background Metabolic syndrome is a cluster of factors that increase the risk of cardiovascular disease and include: diabetes and prediabetes, abdominal obesity, elevated triglycerides, low high-density lipoprotein cholesterol and high blood-pressure. However, the role of the pharmacist in the metabolic syndrome has not yet been fully explored. Aim of the review This systematic review aimed to critically appraise, synthesise, and present the available evidence on pharmacists' input to the screening, prevention and management of metabolic syndrome. Read More

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http://dx.doi.org/10.1007/s11096-020-01084-3DOI Listing

Efficacy of conservative treatments for hand osteoarthritis : An umbrella review of interventional studies.

Wien Klin Wochenschr 2020 Jun 30. Epub 2020 Jun 30.

Centre for Gout and Metabolic Bone and Joint Diseases, Rheumatology, SS Giovanni and Paolo Hospital, Venice, Italy.

Background: Hand osteoarthritis (OA) is common, but the efficacy/safety of treatment interventions aimed to improve health outcomes in this population are not well understood. Therefore, the aim of this study was to map and grade the effect of interventions for health outcomes in hand OA.

Methods: Umbrella review of systematic reviews with meta-analyses of randomized controlled trials (RCTs) using placebo/no intervention as control group. Read More

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http://dx.doi.org/10.1007/s00508-020-01702-0DOI Listing

Lower Limb Asymmetry After Anterior Cruciate Ligament Reconstruction in Adolescent Athletes: A Systematic Review and Meta-Analysis.

J Athl Train 2020 Jun 30. Epub 2020 Jun 30.

Department of Business Administration, University of Zurich, Switzerland.

Objectives: To identify reported (1) common biomechanical asymmetries in the literature after anterior cruciate ligament (ACL) reconstruction in adolescents during landing and (2) timescales for asymmetry to persist postsurgery.

Data Sources: We identified sources by searching the CINAHL, PubMed, Scopus, and SPORTDiscus electronic databases using the following search terms: asymmetry OR symmetry AND landing AND biomechanics OR kinematics OR kinetics.

Study Selection: We screened the titles and abstracts of 85 articles using our inclusion criteria. Read More

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http://dx.doi.org/10.4085/1062-6050-0244-19DOI Listing

Mixed-Methods Systematic Review of Behavioral Interventions in Low- and Middle-Income Countries to Increase Family Support for Maternal, Infant, and Young Child Nutrition during the First 1000 Days.

Curr Dev Nutr 2020 Jun 21;4(6):nzaa085. Epub 2020 May 21.

Program in International Nutrition, Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA.

Fathers, grandmothers, and other family members' influence on maternal, infant, and young child nutrition (MIYCN) is widely recognized, yet synthesis of the effectiveness of engaging them to improve nutrition practices during the first 1000 d is lacking. We examined the impact of behavioral interventions to engage family members in MIYCN in low- and middle-income countries through a mixed-methods systematic review. We screened 5733 abstracts and included 35 peer-reviewed articles on 25 studies (16 with quantitative and 13 with qualitative data). Read More

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http://dx.doi.org/10.1093/cdn/nzaa085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311193PMC

Prevalence of perinatal depression among Japanese women: a meta-analysis.

Ann Gen Psychiatry 2020 26;19:41. Epub 2020 Jun 26.

Department of Psychiatry, Dokkyo Medical University School of Medicine, Tochigi, 321-0293 Japan.

Background: Perinatal depression is one of the important mental illnesses among women. However, not enough reviews have been done, and a certain consensus has not been obtained about the prevalence of perinatal depression among Japanese women. The purpose of our study is to reveal the reliable estimates about the prevalence of perinatal depression among Japanese women. Read More

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http://dx.doi.org/10.1186/s12991-020-00290-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320559PMC

Effect of Insurance Type on Stage at Presentation, Surgical Approach, Tumor Recurrence and Cancer-Specific Survival in Resectable Non-Small Lung Cancer Patients.

Risk Manag Healthc Policy 2020 12;13:559-569. Epub 2020 Jun 12.

Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Purpose: The aim of this study was to identify the association between Thailand's insurance types and stage at presentation, surgical approach, tumor recurrence and cancer-specific survival in resectable non-small cell lung cancer (NSCLC) patients in northern Thailand.

Patients And Methods: Medical records of patients with NSCLC who underwent pulmonary resection at Chiang Mai University Hospital from January 2007 through December 2015 were retrospectively reviewed. Patients were divided into two groups: patients with the Universal Coverage Scheme (UCS) or Social Security Scheme (SSS) and patients with the Civil Servant Medical Benefit Scheme (CSMBS) or private insurance (PI). Read More

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http://dx.doi.org/10.2147/RMHP.S244344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297449PMC

A Randomized, Open-Label, Bioequivalence Study of Lidocaine Topical System 1.8% and Lidocaine Patch 5% in Healthy Subjects.

J Pain Res 2020 22;13:1485-1496. Epub 2020 Jun 22.

Mid America PolyClinic, Overland Park, KS, USA.

Purpose: This study was designed to characterize drug delivery with lidocaine topical system 1.8% vs lidocaine patch 5% through 2 PK studies.

Patients And Methods: Two Phase 1, single-center, open-label, randomized PK studies were performed in healthy adults. Read More

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http://dx.doi.org/10.2147/JPR.S237934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319520PMC

Profile of Polatuzumab Vedotin in the Treatment of Patients with Relapsed/Refractory Non-Hodgkin Lymphoma: A Brief Report on the Emerging Clinical Data.

Onco Targets Ther 2020 8;13:5123-5133. Epub 2020 Jun 8.

Department of Internal Medicine, Division of Hematology, Arthur G. James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA.

Abstract: Polatuzumab vedotin is an anti-CD79b antibody conjugated to monomethyl auristatin E that has shown significant clinical activity in follicular and diffuse large B-cell lymphoma (DLBCL) and is currently FDA-approved in combination with bendamustine and rituximab for patients with relapsed/refractory DLBCL. This review article summarizes data from clinical trials of polatuzumab and discusses its current role and future directions in the treatment of patients with B-cell non-Hodgkin lymphoma.

Methods: We conducted a literature search in PubMed and Google Scholar from inception to January 2020, using the following terms: polatuzumab and CD79. Read More

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http://dx.doi.org/10.2147/OTT.S219449DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293382PMC

B-cell maturation antigen expression across hematologic cancers: a systematic literature review.

Blood Cancer J 2020 Jun 30;10(6):73. Epub 2020 Jun 30.

Memorial Sloan Kettering Cancer Center, New York, NY, USA.

B-cell maturation antigen (BCMA) plays a critical role in regulating B-cell proliferation and survival. There is evidence for BCMA expression in various hematologic malignancies, suggesting that BCMA may play an important role as a biomarker or therapeutic target in these diseases. Given advances in understanding the role of BCMA in B-cell development and the promise of BCMA as a therapeutic target, a systematic review is needed to rigorously assess the evidence for BCMA expression and identify areas of consensus and future research. Read More

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http://dx.doi.org/10.1038/s41408-020-0337-yDOI Listing

Use of Duloxetine for Postprostatectomy Stress Urinary Incontinence: A Systematic Review.

Eur Urol Focus 2020 Jun 27. Epub 2020 Jun 27.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK. Electronic address:

Context: The recommended treatment of postprostatectomy stress urinary incontinence (PPSUI) after failure of pelvic floor muscle training is primarily surgical intervention with a male sling or artificial urinary sphincter. The use of pharmacological therapy in this setting is unlicensed and controversial.

Objective: To systematically review the available evidence regarding the efficacy and safety of duloxetine for the treatment of stress urinary incontinence following prostate surgery (radical or endoscopic). Read More

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http://dx.doi.org/10.1016/j.euf.2020.06.007DOI Listing